Updated on 2024/09/05

Information

 

写真a

 
KAKUTA YOSHIMITSU
 
Organization
Faculty of Agriculture Department of Bioscience and Biotechnology Professor
School of Agriculture Department of Bioresource and Bioenvironment(Concurrent)
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioscience and Biotechnology(Concurrent)
Title
Professor
Contact information
メールアドレス
Profile
My main research is structural biology about sulfotransferase and glycosyltransferase.
External link

Degree

  • PhD.

Research Interests・Research Keywords

  • Research theme:Structural biology about sulfotransferase and glycosyltransferase

    Keyword:Structural biology, Crystallograpy, Sulfotransferase, Glycosyltransferase

    Research period: 1995.4

Awards

  • 農芸化学奨励賞

    2007.3   日本芸農芸化学会   X線結晶構造解析による酵素反応の分子機構に関する研究

Papers

  • A new type of sulfation reaction: C-sulfonation for α, β-unsaturated carbonyl groups by a novel sulfotransferase Reviewed International journal

    2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1093/pnasnexus/pgae097

  • Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of the tick anticoagulant protein madanin Reviewed International journal

    Misa Yoshimura, Takamasa Teramoto, Hirai Asano, Yuka Iwamoto, Mariko Kondo, Etsuko Nishimoto, Yoshimitsu Kakuta

    J Biol Chem.   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.jbc.2024.105748

    Repository Public URL: https://hdl.handle.net/2324/7173532

  • Crystal structure of mango α1,3/α1,4-fucosyltransferase elucidates unique elements that regulate Lewis a-dominant oligosaccharide assembly Reviewed International journal

    2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1093/glycob/cwae015

  • Non-conventional octameric structure of C-phycocyanin Reviewed International journal

    Takuo Minato, Takamasa Teramoto, Naruhiko Adachi, Nguyen Khac Hung, Kaho Yamada, Masato Kawasaki, Masato Akutsu, Toshio Moriya, Toshiya Senda, Seiji Ogo, Yoshimitsu Kakuta, Ki-Seok Yoon

    Communications biology   4 ( Article number: 1238 )   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-021-02767-x

  • Minimal protein-only RNase P structure reveals insights into tRNA precursor recognition and catalysis Reviewed International journal

    @Takamasa Teramoto, #Takeshi Koyasu, @Naruhiko Adachi, @Masato Kawasaki, @Toshio Moriya, @Tomoyuki Numata, @Toshiya Senda, @Yoshimitsu Kakuta

    The Journal of Biological Chemistry   297 ( 3 )   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.101028.

  • Structural Insight Into the Recognition of Pathogen-Derived Phosphoglycolipids by C-type Lectin Receptor DCAR Reviewed International journal

    Zakaria Omahdi, #Yuto Horikawa, Masamichi Nagae, Kenji Toyonaga, Akihiro Imamura, Koichi Takato, Takamasa Teramoto, Hideharu Ishida, Yoshimitsu Kakuta, Sho Yamasaki

    The Journal of Biological Chemistry   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.RA120.012491

  • Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1. Reviewed International journal

    Tanaka S, Nishiyori T, Kojo H, Otsubo R, Tsuruta M, Kurogi K, Liu MC, Suiko M, Sakakibara Y, Kakuta Y

    Scientific Reports   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-07141-8.

  • A rationally engineered yeast pyruvyltransferase Pvg1p introduces sialylation-like properties in neo-human-type complex oligosaccharide. Reviewed International journal

    Yujiro Higuchi, Yoshinaga S, Tateno H, Hirabaysshi J, Nakakita S, Kenakiyo M, Kakuta Y, Takegawa K

    Scientific Reports   ( 6 )   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep26349.

  • The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein Reviewed International journal

    Kawaguchi Y, Sugiura N, Kimata K, Kimura M, Kakuta Y

    FEBS Letters   2013.12

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  • Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction Reviewed International journal

    Teramoto T, Fujikawa Y, Kawaguchi Y, Kurogi K, Soejima M, Adachi R, Nakanishi Y, Mishiro-Sato E, Liu MC, Sakakibara Y, Suiko M, Kimura M, Kakuta Y

    Nature Communications   2013.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038

  • Glucuronyltransferase activity of KfiC from Escherichia coli strain K5 requires association of KfiA: KfiC and KfiA are essential enzymes for production of K5 polysaccharide, N-acetylheparosan. Reviewed International journal

    Sugiura N, Baba Y, Kawaguchi Y, Iwatani T, Suzuki K, Kusakabe T, Yamagishi K, Kimata K, Kakuta Y, Watanabe H.

    The Journal of Biological Chemistry   285 ( 3 )   2010.1

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  • On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases. Reviewed International journal

    Teramoto T, Adachi R, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y.

    FEBS Lett.   2009.9

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  • Snapshot of a Michaelis complex in a sulfuryl transfer reaction: Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate. Reviewed International journal

    Teramoto T, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y.

    Biochem Biophys Res Commun.   2009.5

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  • Structural basis for the broad range substrate specificity of a novel mouse cytosolic sulfotransferase--mSULT1D1. Reviewed International journal

    Teramoto T, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y.

    Biochem Biophys Res Commun.   2009.1

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  • Crystal structure of chondroitin polymerase from Escherichia coli K4. Reviewed International journal

    Osawa T, Sugiura N, Shimada H, Hirooka R, Tsuji A, Shirakawa T, Fukuyama K, Kimura M, Kimata K, Kakuta Y.

    Biochem Biophys Res Commun.   2009.1

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  • Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. Reviewed International journal

    Takagi H, Kakuta Y, Okada T, Yao M, Tanaka I, Kimura M.

    Nature structural & molecular biology   12 ( 4 )   327 - 331   2005.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nsmb911

  • Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution. Reviewed International journal

    Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y.

    The Journal of Molecular Biology   345 ( 5 )   1111 - 1118   2005.2

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    DOI: 10.1016/j.jmb.2004.10.081

  • The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Reviewed International journal

    Yamagata A., Kakuta Y., Masui R., Fukuyama K.

    Proceedings of the National Academy of Sciences of the United States of America.   2002.4

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  • Crystal structure of sulfotransferase domain of human heparan sulfate N-deacetylase/N-sulfotransferase 1. Reviewed International journal

    Kakuta, Y., Sueyoshi, T., Negishi, M., and Pedersen, L.C.

    The Journal of Biological Chemistry   1999.1

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  • Conserved structural motifs of the sulfotransferase family. Reviewed International journal

    Kakuta, Y., Pedersen, L.C., Pedersen, L.G., and Negishi, M.

    Trends in Biochemical Sciences   1998.1

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  • Crystal structure of estrogen sulphotransferase. Reviewed International journal

    Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC.

    Nature structural biology   1997.11

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  • KIF22 regulates mitosis and proliferation of chondrocyte cells

    Kawaue, H; Matsubara, T; Nagano, K; Ikedo, A; Rojasawasthien, T; Yoshimura, A; Nakatomi, C; Imai, Y; Kakuta, Y; Addison, WN; Kokabu, S

    ISCIENCE   27 ( 7 )   110151   2024.7   eISSN:2589-0042

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    Point mutations in KIF22 have been linked to spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). Skeletal features of SEMDJL2 include short stature and joint laxity. Mechanisms underlying these limb abnormalities are unknown. Here in this manuscript, we have investigated the function of KIF22 in chondrocytes. Quantitative PCR and immunostaining revealed that Kif22 was highly expressed in proliferating-zone growth-plate chondrocytes. Kif22 knockdown resulted in defective mitotic spindle formation and reduced cell proliferation. Forced expression of SEMDJL-associated mutant Kif22 constructs likewise induced abnormal mitotic spindle morphology and reduced proliferation. Mice expressing a KIF22 truncation mutant had shorter growth plates and shorter tibial bones compared to wild-type mice. These results suggest that KIF22 regulates mitotic spindle formation in proliferating chondrocytes thereby linking the stunted longitudinal bone growth observed in SEMDJL2 to failures of chondrocyte division.

    DOI: 10.1016/j.isci.2024.110151

    Web of Science

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    PubMed

  • Crystal structure of activating sulfotransferase SgdX2 involved in biosynthesis of secondary metabolite sungeidine

    Mori, T; Teramoto, T; Kakuta, Y

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   711   149891   2024.6   ISSN:0006-291X eISSN:1090-2104

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    Language:English   Publisher:Biochemical and Biophysical Research Communications  

    Microorganisms synthesize a plethora of complex secondary metabolites, many of which are beneficial to human health, such as anticancer agents and antibiotics. Among these, the Sungeidines are a distinct class of secondary metabolites known for their bulky and intricate structures. They are produced by a specific biosynthetic gene cluster within the genome of the soil-dwelling actinomycete Micromonospora sp. MD118. A notable enzyme in the Sungeidine biosynthetic pathway is the activating sulfotransferase SgdX2. In this pathway, SgdX2 mediates a key sulfation step, after which the product undergoes spontaneous dehydration to yield a Sungeidine compound. To delineate the structural basis for SgdX2's substrate recognition and catalytic action, we have determined the crystal structure of SgdX2 in complex with its sulfate donor product, 3′-phosphoadenosine 5′-phosphate (PAP), at a resolution of 1.6 Å. Although SgdX2 presents a compact overall structure, its core elements are conserved among other activating sulfotransferases. Our structural analysis reveals a unique substrate-binding pocket that accommodates bulky, complex substrates, suggesting a specialized adaptation for Sungeidine synthesis. Moreover, we have constructed a substrate docking model that provides insights into the molecular interactions between SgdX2 and Sungeidine F, enhancing our understanding of the enzyme's specificity and catalytic mechanism. The model supports a general acid-base catalysis mechanism, akin to other sulfotransferases, and underscores the minor role of disordered regions in substrate recognition. This integrative study of crystallography and computational modeling advances our knowledge of microbial secondary metabolite biosynthesis and may facilitate the development of novel biotechnological applications.

    DOI: 10.1016/j.bbrc.2024.149891

    Web of Science

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  • Crystal structure of activating sulfotransferase SgdX2 involved in biosynthesis of secondary metabolite sungeidine Reviewed International journal

    #Takahiro Mori, @Takamasa Teramoto, @Yoshimitsu Kakuta

    Biochemical and Biophysical Research Communications   2024.4

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    DOI: in press

  • A new type of sulfation reaction: C-sulfonation for α,β-unsaturated carbonyl groups by a novel sulfotransferase SULT7A1

    Kurogi, K; Sakakibara, Y; Hashiguchi, T; Kakuta, Y; Kanekiyo, M; Teramoto, T; Fukushima, T; Bamba, T; Matsumoto, J; Fukusaki, E; Kataoka, H; Suiko, M

    PNAS NEXUS   3 ( 3 )   pgae097   2024.2   eISSN:2752-6542

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    Cytosolic sulfotransferases (SULTs) are cytosolic enzymes that catalyze the transfer of sulfonate group to key endogenous compounds, altering the physiological functions of their substrates. SULT enzymes catalyze the O-sulfonation of hydroxy groups or N-sulfonation of amino groups of substrate compounds. In this study, we report the discovery of C-sulfonation of α,β-unsaturated carbonyl groups mediated by a new SULT enzyme, SULT7A1, and human SULT1C4. Enzymatic assays revealed that SULT7A1 is capable of transferring the sulfonate group from 3′-phosphoadenosine 5′-phosphosulfate to the α-carbon of α,β-unsaturated carbonyl-containing compounds, including cyclopentenone prostaglandins as representative endogenous substrates. Structural analyses of SULT7A1 suggest that the C-sulfonation reaction is catalyzed by a novel mechanism mediated by His and Cys residues in the active site. Ligand-activity assays demonstrated that sulfonated 15-deoxy prostaglandin J2 exhibits antagonist activity against the prostaglandin receptor EP2 and the prostacyclin receptor IP. Modification of α,β-unsaturated carbonyl groups via the new prostaglandin-sulfonating enzyme, SULT7A1, may regulate the physiological function of prostaglandins in the gut. Discovery of C-sulfonation of α,β-unsaturated carbonyl groups will broaden the spectrum of potential substrates and physiological functions of SULTs.

    DOI: 10.1093/pnasnexus/pgae097

    Web of Science

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    PubMed

  • Disassembly and reassembly of the non-conventional thermophilic C-phycocyanin Reviewed International journal

    Hung Khac Nguyen, Takuo Minato, Takamasa Teramoto, Seiji Ogo, Yoshimitsu Kakuta, Ki-Seok Yoon

    Journal of Bioscience and Bioengineering   2024.1

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    DOI: https://doi.org/10.1016/j.jbiosc.2023.12.015

  • Crystal structure of Arabidopsis thaliana sulfotransferase SOT16 involved in glucosinolate biosynthesis Reviewed International journal

    #Yuka Iwamoto, @Seira Saito, @Takamasa Teramoto, @Akiko Maruyama-Nakashita, @Yoshimitsu Kakuta

    Biochemical and Biophysical Research Communications   677   149 - 154   2023.10

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    DOI: doi.org/10.1016/j.bbrc.2023.08.020

  • Crystal structure of adenosine 5'-phosphosulfate kinase isolated from Archaeoglobus fulgidus Reviewed International journal

    #Tomoya Kawakami, @Takamasa Teramoto, @Yoshimitsu Kakuta

    Biochemical and Biophysical Research Communications   643   105 - 110   2023.2

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    DOI: 10.1016/j.bbrc.2022.12.081.

  • The crystal structure of mouse SULT2A8 reveals the mechanism of 7α-hydroxyl, bile acid sulfation Reviewed International journal

    562   15 - 20   2021.7

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    DOI: 10.1016/j.bbrc.2021.04.113

  • Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA Reviewed International journal

    Takamasa Teramoto, Kipchumba J Kaitany, Yoshimitsu Kakuta, Makoto Kimura, Carol A Fierke, Traci M Tanaka Hall

    Nucleic Acids Res   48 ( 21 )   11815 - 11826   2020.12

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    DOI: 10.1093/nar/gkaa627

  • Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites Reviewed International journal

    Minato, Takuo; Teramoto, Takamasa; Kakuta, Yoshimitsu; Ogo, Seiji; Yoon, Ki-Seok

    FEBS Open Bio   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2211-5463.12837

  • Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ Reviewed International journal

    2020.2

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    DOI: 10.1021/acs.chemrestox.9b00379

  • Functional implication of archaeal homologues of human RNase P protein pair Pop5 and Rpp30. Reviewed International journal

    Hamasaki M, Hazeyama K, Iwasaki F, Ueda T, Nakashima T, Kakuta Y, Kimura M

    Journal of Biochemistry   159 ( 1 )   31 - 40   2016.1

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    DOI: 10.1093/jb/mvv067

  • Mutation of the gene encoding the ribonuclease P RNA in the hyperthermophilic archaeon Thermococcus kodakarensis causes decreased growth rate and impaired process. Reviewed International journal

    Ueda T, Ishino S, Suematsu K, Nakashima T, Kakuta Y, Kimura M

    Biochem Biophys Res Commun.   468 ( 4 )   660 - 665   2015.12

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    DOI: 10.1016/j.bbrc.2015.11.012.

  • Archaeal ribonuclease P proteins have potential for biotechnological applications where precise hybridization of nucleic acids is needed. Reviewed International journal

    Miyanoshita M, Nakashima T, Kakuta Y, Kimura M

    Biosci Biotechnol Biochem.   79 ( 12 )   2014 - 2017   2015.6

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    DOI: 10.1080/09168451.2015.1058699

  • On archaeal homologs of the human RNase P proteins Pop5 and Rpp30 in the hyperthermophilic archaeon Thermococcus kodakarensis. Reviewed International journal

    Suematsu K, Ueda T, Nakashima T, Kakuta Y, Kimura M

    Biosci Biotechnol Biochem.   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2014.1003130

  • Enhancement of RNA annealing and strand displacement found in archaeal ribonuclease P proteins is conserved in Escherichia coli protein C5 and yeast protein Rpr2 Reviewed International journal

    Furutani T, Hazeyama K, Ueda T, Tomita S, Imai T, Gao X, Nakashima T, Kakuta Y, Kimura M

    Biosci Biotechnol Biochem.   2014.10

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    DOI: 10.1080/09168451

  • Characterization of putative toxin/antitoxin systems in Vibrio parahaemolyticus. Reviewed International journal

    Hino M, Zhang J, Takagi H, Miyoshi T, UchiumiT, Nakashima T, Kakuta Y, Kimura M

    J Appl Microbiol.   2014.9

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    DOI: 10.1111

  • Pentatricopeptide repeat motifs in the processing enzyme PRORP1 in Arabidopsis thaliana play a crucial role in recognition of nucleotide bases at TψC loop in precursor tRNAs Reviewed International journal

    2014.8

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    DOI: 10.1016

  • Tamavidin 2-HOT, a highly thermostable biotin-binding protein Reviewed International journal

    Takakura Y, Suzuki J, Oka N, Kakuta Y

    Journal of Biotechnology   2014.1

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  • Characterization of the peripheral structures of archaeal RNase P RNA from Pyrococcus horikoshii OT3 Reviewed International journal

    Ueda T, Yamaguchi H, Miyanoshita M, Nakashima T, Kakuta Y, Kimura M

    The Journal of Biochemistry   2014.1

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    DOI: 10.1093/jb/mvt092

  • Extra-structural elements in the RNA recognition motif in archaeal Pop5 play a crucial role in the activation of RNase P RNA from Pyrococcus horikoshii OT3 Reviewed International journal

    Hazeyama K, Ishihara M, Ueda T, Nishimoto E, Nakashima T, Kakuta Y, Kimura M

    Biochemical and Biophysical Research Communications   2013.11

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  • A distinct binding mode of archaeal ribonuclease P proteins to RNA Reviewed International journal

    Ishihara M, Nishimoto E, Yamashita S, Kakuta Y, Kimura M

    Biosci Biotechnol Biochem. 76(12):2335-7.   2012.12

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  • Single-molecular enzymatic elongation of hyaluronan polymers visualized by high-speed atomic force microscopy Reviewed International journal

    Mori T, Hirose A, Hagiwara T, Ohtsuka M, Kakuta Y, Kimata K, Okahata Y

    J Am Chem Soc. 134(50):20254-7.   2012.12

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    DOI: 10.1021

  • The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis. Reviewed International journal

    Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M

    J Biol Chem. 287(43):36022-8.   2012.10

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  • Structural basis for catalytic activity of a silkworm Delta-class glutathione transferase Reviewed International journal

    Yamamoto K, Usuda K, Kakuta Y, Kimura M, Higashiura A, Nakagawa A, Aso Y, Suzuki M

    Biochim Biophys Acta. 2012 Oct;1820(10):1469-74.   2012.10

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  • Loss-of-function mutation in bi-functional marine bacterial sialyltransferase Reviewed International journal

    Kajiwara H, Katayama S, Kakuta Y, Okino N, Ito M, Mine T, Yamamoto T

    Biosci Biotechnol Biochem. 2012;76(9):1639-44.   2012.9

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  • Crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose Reviewed International journal

    Chaen K, Noguchi J, Omori T, Kakuta Y, Kimura M

    Biochem Biophys Res Commun. 2012 424(3):508-11.   2012.8

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  • Kinetics of iterative carbohydrate transfer to polysaccharide catalyzed by chondroitin polymerase on a highly sensitive flow-type 27 MHz quartz-crystal microbalance Reviewed International journal

    2012.6

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  • Thermodynamic analysis of a multifunctional RNA-binding protein, PhoRpp38, in the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

    Oshima K, Nakashima T, Kakuta Y, Tsumoto K, Kimura M

    Biosci Biotechnol Biochem. 2012;76(6):1252-5.   2012.6

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  • Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66. Reviewed International journal

    Kawaguchi Y, Sugiura N, Onishi M, Kimata K, Kimura M, and Kakuta Y.

    Acta. Crystallogr. Sect F   68   2012.2

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  • Crystal structure of sulfotransferase STF9 from Mycobacterium avium. Reviewed International journal

    Hossain MM, Moriizumi Y, Tanaka S, Kimura M, Kakuta Y.

    Mol Cell Biochem.   ( 361 )   2012.2

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  • Structural modeling of RNase P RNA from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

    Zwieb C, Nakao Y, Nakashima H, Takagi H, Goda S, Andersen E.S, Kakuta Y, and Kimura M.

    Biochem Biophys Res Commun.   in press   2011.10

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  • Molecular cloning, expression, and functional analysis of a predicted sulfotransferase STF9 from Mycobacterium avium. Reviewed International journal

    Hossain MM, Moriizumi Y, Tanaka S, Kimura M, Kakuta Y.

    Mol Cell Biochem.   350 ( (1-2) )   2011.10

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  • Crystallographic survey of active sites of an unclassified glutathione transferase from Bombyx mori.

    Kakuta Y, Usuda K, Nakashima T, Kimura M, Aso Y, Yamamoto K.

    Biochim Biophys Acta.   in press   2011.7

  • The Contribution of Peripheral Stem-Loops to the Catalytic Activity of Archaeal RNase P RNA from Pyrococcus horikoshii OT3. Reviewed International journal

    Hara T, Terada A, Yamaguchi H, Nakashima T, Kakuta Y, Kimura M.

    Biosci Biotechnol Biochem.   75(4)   2011.5

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  • Crystal structure of the branching enzyme I (BEI) from Oryza sativa L with implications for catalysis and substrate binding. Reviewed International journal

    Noguchi J, Chaen K, Vu NT, Akasaka T, Shimada H, Nakashima T, Nishi A, Satoh H, Omori T, Kakuta Y, Kimura M.

    Glycobiology   ( 8 )   2011.4

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  • The structural mechanism of the inhibition of archaeal RelE toxin by its cognate RelB antitoxin. Reviewed International journal

    Shinohara M, Guo JX, Mori M, Nakashima T, Takagi H, Nishimoto E, Yamashita S, Tsumoto K, Kakuta Y, Kimura M.

    Biochem Biophys Res Commun.   400   2010.9

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  • Structure of the newly found green turtle egg-white ribonuclease. Reviewed International journal

    Katekaew S, Kuaprasert B, Torikata T, Kakuta Y, Kimura M, Yoneda K, Araki T.

    Acta. Crystallogr. Sect F   66   2010.6

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  • Zebrafish as a model for the study of the phase II cytosolic sulfotransferases. Reviewed International journal

    Liu TA, Bhuiyan S, Liu MY, Sugahara T, Sakakibara Y, Suiko M, Yasuda S, Kakuta Y, Kimura M, Williams FE, Liu MC.

    Curr. Drug Metab.   6   2010.6

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  • Expression and functional analysis of a predicted AtsG arylsulfatase identified from Mycobacterium tuberculosis genomic data. Reviewed International journal

    Hossain MM, Kawarabayasi Y, Kimura M, Kakuta Y.

    J Biochem.   146 ( 6 )   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Crystal structure of alpha/beta-galactoside alpha2,3-sialyltransferase from a luminous marine bacterium, Photobacterium phosphoreum Reviewed International journal

    Iwatani T, Okino N, Sakakura M, Kajiwara H, Takakura Y, Kimura M, Ito M, Yamamoto T, Kakuta Y.

    FEBS Lett.   2009.6

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  • Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. Reviewed International journal

    Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M.

    J Biol Chem.   2009.4

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  • Tamavidins--novel avidin-like biotin-binding proteins from the Tamogitake mushroom. Reviewed International journal

    Takakura Y, Tsunashima M, Suzuki J, Usami S, Kakuta Y, Okino N, Ito M, Yamamoto T.

    FEBS J.   2009.3

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  • Structure of an archaeal homolog of the human protein complex Rpp21-Rpp29 that is a key core component for the assembly of active ribonuclease P. Reviewed International journal

    Honda T, Kakuta Y, Kimura K, Saho J, Kimura M.

    J Mol Biol.   2008.12

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  • Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus. Reviewed International journal

    Satone H, Oshima Y, Shimasaki Y, Tawaratsumida T, Oba Y, Takahashi E, Kitano T, Kawabata S, Kakuta Y, Honjo T.

    Aquat Toxicol.   2008.12

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  • The Chondroitin Polymerase K4CP and the Molecular Mechanism of Selective Bindings of Donor Substrates to Two Active Sites. Reviewed International journal

    Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M.

    J Biol Chem.   2008.11

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  • Biochemical and Crystallographic Characterization of the Starch Branching Enzyme I (BEI) from Oryza sativa L. Reviewed International journal

    Vu NT, Shimada H, Kakuta Y, Nakashima T, Ida H, Omori T, Nishi A, Satoh H, Kimura M.

    Biosci Biotechnol Biochem.   2008.11

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  • Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. Reviewed International journal

    Teramoto T, Sakakibara Y, Inada K, Kurogi K, Liu MC, Suiko M, Kimura M, Kakuta Y.

    FEBS Lett.   2008.11

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  • Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase Reviewed International journal

    Noguchi J, Hayashi Y, Baba Y, Okino N, Kimura M, Ito M, Kakuta Y.

    Biochem Biophys Res Commun.   2008.9

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  • ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner. Reviewed

    Matsushima A, Teramoto T, Okada H, Liu X, Tokunaga T, Kakuta Y, Shimohigashi Y.

    Biochem Biophys Res Commun.   2008.8

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  • Crystal structure and functional analysis of an archaeal chromatin protein Alba from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

    Hada K, Nakashima T, Osawa T, Shimada H, Kakuta Y, Kimura M.

    Biosci Biotechnol Biochem.   2008.3

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  • Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha-2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition. Reviewed International journal

    Kakuta Y, Okino N, Kajiwara H, Ichikawa M, Takakura Y,Ito M, Yamamoto T

    Glycobiology   2008.1

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  • Crystal structure of an archaeal Ski2p-like protein from Pyrococcus horikoshii OT3. Reviewed International journal

    Zhang X, Nakashima T, Kakuta Y, Yao M, Tanaka I, Kimura M.

    Protein Sci.   2008.1

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  • Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR{gamma} Reviewed International journal

    Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata SI, Kimura M, Shimohigashi Y.

    J Biochem (Tokyo)   2007.10

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  • Klotho-related Protein Is a Novel Cytosolic Neutral beta-Glycosylceramidase. Reviewed International journal

    Hayashi Y, Okino N, Kakuta Y, Shikanai T, Tani M, Narimatsu H, Ito M.

    J Biol Chem.   2007.10

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  • Crystal Structure of Tapes japonica Lysozyme with Substrate Analogue: STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND MANIFESTATION OF ITS CHITINASE ACTIVITY ACCOMPANIED BY QUATERNARY STRUCTURAL CHANGE. Reviewed International journal

    Goto T, Abe Y, Kakuta Y, Takeshita K, Imoto T, Ueda T.

    J Biol Chem.   2007.9

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  • Purification, crystallization and preliminary crystallographic characterization of the alpha 2,6-sialyltransferase from Photobacterium sp. JT-ISH-224. Reviewed International journal

    Okino N, Kakuta Y, Kajiwara H, Ichikawa M, Takakura Y, Ito M, Yamamoto T.

    Acta Crystallogr Sect F Struct Biol Cryst Commun.   2007.8

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  • Crystal structures of the Nicotiana glutinosa ribonuclease NT in complex with nucleoside monophosphates. Reviewed International journal

    Kawano S, Kakuta Y, Nakashima T, Kimura M.

    J Biochem (Tokyo).   2006.9

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  • A fifth protein subunit Ph1496p elevates the optimum temperature for the ribonuclease P activity from Pyrococcus horikoshii OT3 Reviewed International journal

    Fukuhara H, Kifusa M, Watanabe M, Terada A, Honda T, Numata T, Kakuta Y, Kimura M.

    J Biochem (Tokyo)   2006.5

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  • Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme Reviewed International journal

    Kawano S, Nakashima T, Kakuta Y, Tanaka I, Kimura M

    J. Mol Biol.   2006.3

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  • Crystal Structure of a Ribonuclease P Protein Ph1601p from Pyrococcus horikoshii OT3: An Archaeal Homologue of Human Nuclear Ribonuclease P Protein Rpp21 Reviewed International journal

    Kakuta Y, Ishimatsu I, Numata T, Kimura K, Yao M, Tanaka I, Kimura M.

    Biochemistry   44 ( 36 )   12086 - 12093   2005.9

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    DOI: 10.1021/bi050738z

  • Crystal structure of Escherichia coli YfhJ protein, a member of the ISC machinery involved in assembly of iron-sulfur clusters. Reviewed International journal

    Shimomura Y, Takahashi Y, Kakuta Y, Fukuyama K.

    Proteins.   60 ( 3 )   566 - 569   2005.8

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    DOI: 10.1002/prot.20481

  • Overproduction, purification and preliminary X-ray diffraction analysis of a sulfotransferase from Mycobacterium tuberculosis H37Rv. Reviewed International journal

    Tanaka S, Moriizumi Y, Kimura M, Kakuta Y.

    Acta Crystallograph Sect F Struct Biol Cryst Commun.   61   33 - 35   2005.1

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    DOI: 10.1107/S1744309104022328

  • Crystal structure of archaeal ribonuclease P protein Ph1771p from Pyrococcus horikoshii OT3: an archaeal homolog of eukaryotic ribonuclease P protein Rpp29. Reviewed International journal

    Numata T, Ishimatsu I, Kakuta Y, Tanaka I, Kimura M.

    RNA.   10 ( 9 )   1423 - 1432   2004.9

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    DOI: 10.1261/rna.7560904

  • Amino acids conserved at the C-terminal half of the ribonuclease T2 family contribute to protein stability of the enzymes. Reviewed International journal

    Kimura K, Numata T, Kakuta Y, Kimura M.

    Biosci Biotechnol Biochem.   68 ( 8 )   1748 - 1757   2004.8

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    DOI: 10.1271/bbb.68.1748

  • Crystal structure of the regulatory subunit of archaeal initiation factor 2B (aIF2B) from hyperthermophilic archaeon Pyrococcus horikoshii OT3: a proposed structure of the regulatory subcomplex of eukaryotic IF2B Reviewed International journal

    Kakuta Y, Tahara M, Maetani S, Yao M, Tanaka I, Kimura M.

    Biochem. Biophys. Res. Commun   319 ( 3 )   725 - 732   2004.7

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    DOI: 10.1016/j.bbrc.2004.05.045

  • Crystal structure of the ribonuclease P protein Ph1877p from hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

    Takagi H, Watanabe M, Kakuta Y, Kamachi R, Numata T, Tanaka I, Kimura M.

    Biochem Biophys Res Commun.   319 ( 3 )   787 - 794   2004.7

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    DOI: 10.1016/j.bbrc.2004.05.055

  • Overproduction, crystallization and preliminary X-ray diffraction analysis of probable ATP sulfurylase from Thermus thermophilus HB8 Reviewed International journal

    Taguchi Y, Hoseki J, Kakuta Y, Fukuyama K.

    Acta. Crystallogr. D   2003.9

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  • Crystal Structures of the Quinone Oxidoreductase from Thermus thermophilus HB8 and Its Complex with NADPH: Implication for NADPH and Substrate Recognition Reviewed International journal

    Shimomura Y, Kakuta Y, Fukuyama K.

    J. Bacteriol.   185 ( 14 )   4211 - 4218   2003.7

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    DOI: 10.1128/JB.185.14.4211.4218.2003

  • Crystal Structures of the Ribonuclease MC1 Mutants N71T and N71S in Complex with 5’-GMP: Structural Basis for Alterations in Substrate Specificity Reviewed International journal

    42 ( 18 )   5270 - 5278   2003.5

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    DOI: 10.1021/bi034103g

  • Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition Reviewed International journal

    Kakuta Y, Li L, Pedersen LC, Pedersen LG, Negishi M.

    Biochem. Soc. Trans   2003.4

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  • Guanine binding site of the Nicotiana glutinosa ribonuclease NW revealed by X-ray crystallography. Reviewed International journal

    Kawano S., Kakuta Y., and Kimura M.

    Biochemistry   41 ( 51 )   15195 - 15202   2002.1

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    DOI: 10.1021/bi0262471

  • Atomic resolution structures of oxidized [4Fe-4S] ferredoxin from Bacillus thermoproteolyticus in two crystal forms: systematic distortion of [4Fe-4S] cluster in the protein. Reviewed International journal

    Fukuyama K., Okada T., Kakuta Y., Takahashi Y.

    Journal of Molecular Biology   2002.1

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  • Crystal Structure of Rat Apo-Heme Oxygenase-1 (HO-1): Mechanism of Heme Binding in HO-1 Inferred from Structural Comparison of the Apo and Heme Complex Forms. Reviewed International journal

    Sugishima M., Sakamoto H., Kakuta Y., Omata Y., Hayashi S., Noguchi M., Fukuyama K.

    Biochemistry   2002.1

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  • Overexpression, purification and characterization of RecJ protein from Thermus thermophilus HB8 and its core domain. Reviewed International journal

    Yamagata A., Masui R., Kakuta Y., Kuramitsu S., Fukuyama K.

    Nucleic Acids Research   2001.1

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  • Crystal structure of the Escherichia coli Fdx, an Adrenodoxin-type Ferredoxin Involved in the Assembly of Iron-Sulfur Clusers. Reviewed International journal

    Kakuta Y., Horio T., Takahashi Y., and Fukuyama K.

    Biochemistry   2001.1

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  • Structure-Function Modeling of the Interactions of N-Alkyl-N-hydroxyanilines with Rat Hepatic Aryl Sulfotransferase IV. Reviewed International journal

    King RS, Sharma V., Pedersen L.C., Kakuta Y., Negishi M., and Duffel MW.

    Chem Res Toxicol   2000.1

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  • Crystal structure of rat heme oxygenase-1 in complex with heme. Reviewed International journal

    Sugishima M., Omata Y., Kakuta Y., Sakamoto H., Noguchi M., and Fukuyama K.

    FEBS Letter   2000.1

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  • Substrate gating confers steroid specificity to estrogen sulfotransferase. Reviewed International journal

    Petrotchenko EV, Doerflein ME, Kakuta Y., Pedersen L.C., and Negishi M.

    The Journal of Biological Chemistry   1999.1

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  • 3'-Phosphoadenosine 5'-phosphosulfate binding site of flavonol 3-sulfotransferase srudied by affinity chromatography and 31P NMR. Reviewed International journal

    Marsolais, F., Laviolette, M., Kakuta, Y., Negishi, M., Pedersen, L.C., Auger, M., and Varin, L.

    Biochemistry   1999.1

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  • A quantum mechanical study of the transfer of biological sulfate. Reviewed International journal

    Bartolotti, L., Kakuta, Y., Pedersen, L.C., Negishi, M., and Pedersen, L.G.

    Theochem-Journal of Molecular Structure.   1999.1

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  • Crystal structure of human catecholamine sulfotransferase. Reviewed International journal

    Bidwell LM, McManus ME, Gaedigk A, Kakuta Y., Negishi M., Pedersen L., and Martin JL.

    Journal of Molecular Biology   1999.1

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  • The sulfuryl transfer mechanism: Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis. Reviewed International journal

    Kakuta, Y., Petrotchenko E.V., Pedersen, L.C., and Negishi, M.

    The Journal of Biological Chemistry   1998.1

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  • A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotranferase. Reviewed International journal

    Sueyoshi, T., Kakuta, Y., Pedersen, L.C., Frances, E.W., Pedersen, L.G., and Negishi, M.

    FEBS Letter   1998.1

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  • Mouse steroid sulfotransferases: substrate specificity and preliminary X-ray crystallographic analysis. Reviewed International journal

    Kakuta, Y., Pedersen, L.C., Chae, K., Song, W., Leblanc, D., London, R., Carter, C.W., and Negishi, M.

    Biochemical Pharmacology   1998.1

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  • Glycine-15 in the bend between two alpha-helices can explain the thermostability of DNA binding protein HU from Bacillus stearothermophilus. Reviewed International journal

    Kawamura S, Kakuta Y, Tanaka I, Hikichi K, Kuhara S, Yamasaki N, Kimura M.

    Biochemistry.   35 ( 4 )   1195 - 1200   1996.1

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    DOI: 10.1021/bi951581l

  • 1H NMR study on substituent distribution of cellulose diacetate Reviewed International journal

    Hikichi, K., Kakuta, Y., and Katoh, T.

    Polymer Journal   1995.1

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  • 13C-NMR relaxation study on mobility of the DNA-binding arm of HU. Reviewed International journal

    Kakuta Y, Hojo H, Aimoto S, Tanaka I, Hikichi K.

    J Biochem (Tokyo).   1994.11

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  • Development of a Linker with an Enhanced Stability for the Preparation of Peptide Thioesters and Its Application to the Synthesis of Stable-Isotope-Labelled HU-Type DNA-Binding Protein Reviewed International journal

    Hojo H., Kwon Y.,Kakuta Y.,Tsuda S.,Tanaka I.,Hikichi K., and Aimoto S.

    Bull. Chem. Soc. Jpn   1993.9

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Books

  • 日本の結晶学(Ⅱ)- その輝かしい発展-

    Yoshimitsu Kakuta(分担)( Role: Joint author)

    2014.10 

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  • MICROORGANISMS IN SUSTAINABLE AGRICULTURE AND BIOTECHNOLOGY :Structural Biology of the Ribonuclease P in the Hyperthermophilic Archaeon Pyrococcus horikoshii OT3

    Makoto Kimura and Yoshimitsu Kakuta( Role: Joint author)

    2012.4 

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    Responsible for pages:487-508   Language:English   Book type:Scholarly book

Presentations

  • スルホトランスフェラーゼによる生体異物代謝メカニズムに関するX線結晶構造解析

    角田佳充

    日本農芸化学会  2007.3 

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    Event date: 2007.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京農業大学   Country:Japan  

  • K4大腸菌コンドロイチン糖鎖ポリメラーゼの結晶構造解析 Invited

    角田佳充

    日本農芸化学会  2009.3 

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    Event date: 2009.3

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡国際会議場   Country:Japan  

  • 硫酸転移酵素のX線結晶構造解析 Invited

    角田佳充

    化学材料研究セミナー  2009.1 

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    Event date: 2009.1

    Presentation type:Symposium, workshop panel (public)  

    Venue:九州大学国際ホール   Country:Japan  

  • Crystal structure of mouse sulfotransferase 2A4

    Takeaki Nishio,Makiko Sonoda,Takamasa Teramoto,Kanako Inada, Masahito Suikou,Makoto Kimura,Youichi Sakakibara,Yoshimitsu Kakuta

    2008.8 

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    Event date: 2008.8

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Crystal structure of the covalent intermediate of human cytosolic β-glucosidase

    国際結晶学会  2008.8 

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    Event date: 2008.8

    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

MISC

  • リボヌクレアーゼP(RNase P)の多様性・構造基盤と分子進化 Reviewed

    @寺本岳大,#児安剛志、@角田佳充

    バイオサイエンスとインダストリー   2023.5

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  • Crystal structure of endocrine-disrupting chemical bisphenol A and estrogen-related receptor γ Reviewed

    2022.1

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    DOI: https://doi.org/10.1093/jb/mvab145

  • リボヌクレアーゼP(RNase P)の多様性とその構造基盤 Reviewed

    @寺本岳大,#児安剛志、@角田佳充

    生化学(日本生化学会)   2021.12

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    DOI: doi:10.14952/SEIKAGAKU.2021.930857

  • 古細菌リボヌクレアーゼP構成タンパク質の結晶構造解析

    角田佳充、木村 誠

    日本結晶学会誌   2007.9

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  • ヘパラン硫酸スルホトランスフェラーゼの構造生物学

    角田佳充、Lars C. Pedersen、根岸正彦

    蛋白質核酸酵素   2001.1

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  • 植物リボヌクレアーゼの基質認識機構

    沼田 倫征、 河野 慎、 角田 佳充、 木村 誠

    化学と生物   2003.1

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  • Structure and Function of Sulfotransferases

    Negishi, M., Pedersen, L.G., Petrotchenko, E., Shevtsov, S., Gorokho, A., Kakuta, Y., Pedersen, L.C.

    Archives of Biochemistry and Biophysics   2001.1

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  • スルホトランスフェラーゼの構造生物学

    角田佳充、Lars C. Pedersen, 根岸 正彦

    日本結晶学会誌   2000.9

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Professional Memberships

  • 日本生化学会

  • TIGG

  • 日本糖質学会

  • 日本生物物理学会

  • 日本結晶学会

  • 日本蛋白質科学会

  • 日本農芸化学会

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Committee Memberships

  • Councilor   Domestic

    2019.4 - 2021.3   

  • Councilor   Domestic

    2017.1 - 2020.12   

  • Organizer   Domestic

    2011.1 - Present   

  • 日本農芸化学会西日本支部   参与   Domestic

    2011.1 - 2020.12   

  • Organizer   Domestic

    2011.1 - 2012.12   

  • Organizer   Domestic

    2007.11 - 2008.10   

  • 日本農芸化学会   代議員   Domestic

    2007.4 - 2008.3   

  • Organizer   Domestic

    2003.1 - 2004.12   

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Academic Activities

  • プログラム編成

    2014年度 日本農芸化学会西日本支部大会  ( 佐賀大学 ) 2013.9

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    Type:Competition, symposium, etc. 

    Number of participants:300

  • 代表世話人

    第50回化学関連支部合同九州大会および外国人研究者交流国際シンポジウム  ( 北九州国際会議場 ) 2013.7

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    Type:Competition, symposium, etc. 

    Number of participants:1,000

  • 日本結晶学会誌

    2000.4 - 2004.3

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    Type:Academic society, research group, etc. 

Research Projects

  • 吸血生物が持つ血液凝固阻害タンパク質活性化の分子メカニズム解明

    Grant number:24K09353  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 抗凝血・抗炎症ポリペプチドの硫酸化機構の解明

    Grant number:21K05384  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 翻訳後修飾を行う植物タンパク質チロシン硫酸転移酵素の立体構造解析

    Grant number:16K07273  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 真核微生物のステリルグルコシド代謝とその生理機能

    Grant number:15H04488  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 前駆体tRNAプロセシング酵素の構造と機能の解明とその有効利用

    Grant number:15H04487  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • グリコサミノグリカン糖鎖伸長反応メカニズムの解明

    Grant number:25440029  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 真菌類の糖脂質代謝酵素の構造と機能に関する研究

    Grant number:24380058  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • リボ核タンパク質複合体酵素の構造活性相関と耐熱性

    Grant number:22380062  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 宇宙環境を利用した高品質タンパク質結晶生成と精密立体構造の解析

    2009.10 - 2010.9

    受託研究

      More details

    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • スフィンゴ糖脂質代謝マシーナリの構造と機能及び応用に関する研究

    Grant number:21380066  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ヘパロサン糖鎖生合成酵素複合体における連続した糖転移反応効率化メカニズムの解明

    Grant number:21570115  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 高効率な部位特異的硫酸化タンパク質生産法の開発

    2009

    JST シーズ発掘試験研究

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 核内受容体ERRgammaを介したビスファノールAの低用量効果の解明

    Grant number:19201012  2007 - 2009

    日本学術振興会  科学研究費助成事業  基盤研究(A)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • リボ核タンパク質複合体酵素の作用機構に関する研究

    Grant number:19380060  2007 - 2009

    日本学術振興会  科学研究費助成事業  基盤研究(B)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 新しいエンド型・エキソ型グリコサラミダーゼの構造と機能及び応用に関する研究

    Grant number:19380061  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 硫酸転移酵素による多様な生体異物認識の立体構造基盤解明

    Grant number:19570106  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • :

    Grant number:17570094  2005 - 2006

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 不明

    2002 - 2003

    科学研究費助成事業  若手研究(B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 不明

    2000 - 2001

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Class subject

  • 生物物理化学特論

    2024.10 - 2024.12   Fall quarter

  • 生物化学I

    2024.10 - 2024.12   Fall quarter

  • 科学英語

    2024.4 - 2025.3   Full year

  • 応用生命化学発展実験

    2024.4 - 2024.9   First semester

  • 生物機能分子化学Ⅱ

    2024.4 - 2024.9   First semester

  • 生物機能分子化学プロジェクト演習

    2024.4 - 2024.9   First semester

  • 基礎生化学I

    2024.4 - 2024.6   Spring quarter

  • 生物物理化学特論

    2023.10 - 2023.12   Fall quarter

  • 生物物理化学特論

    2023.10 - 2023.12   Fall quarter

  • 生物化学I

    2023.10 - 2023.12   Fall quarter

  • 生物物理化学Ⅱ

    2023.6 - 2023.8   Summer quarter

  • 科学英語

    2023.4 - 2024.3   Full year

  • 応用生命化学発展実験

    2023.4 - 2023.9   First semester

  • 生物機能分子化学プロジェクト演習

    2023.4 - 2023.9   First semester

  • 生物機能分子化学Ⅱ

    2023.4 - 2023.9   First semester

  • 生物物理化学Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 基礎生化学Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 基礎生化学I

    2023.4 - 2023.6   Spring quarter

  • 生物物理化学特論

    2022.10 - 2022.12   Fall quarter

  • 生物化学Ⅰ

    2022.10 - 2022.12   Fall quarter

  • 生物物理化学特論

    2022.10 - 2022.12   Fall quarter

  • 生物化学I

    2022.10 - 2022.12   Fall quarter

  • 生物物理化学Ⅱ

    2022.6 - 2022.8   Summer quarter

  • 科学英語

    2022.4 - 2023.3   Full year

  • 応用生命化学発展実験

    2022.4 - 2022.9   First semester

  • 生物機能分子化学プロジェクト演習

    2022.4 - 2022.9   First semester

  • 生物機能分子化学Ⅱ

    2022.4 - 2022.9   First semester

  • 生物物理化学Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 基礎生化学Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 基礎生化学I

    2022.4 - 2022.6   Spring quarter

  • 生物化学I

    2021.10 - 2021.12   Fall quarter

  • 生物化学Ⅰ

    2021.10 - 2021.12   Fall quarter

  • 生物物理化学特論

    2021.10 - 2021.12   Fall quarter

  • 生物物理化学特論

    2021.10 - 2021.12   Fall quarter

  • 科学英語

    2021.4 - 2022.3   Full year

  • 生物物理化学

    2021.4 - 2021.9   First semester

  • 基礎生化学

    2021.4 - 2021.9   First semester

  • 生物機能分子化学Ⅱ

    2021.4 - 2021.9   First semester

  • 生物機能分子化学プロジェクト演習

    2021.4 - 2021.9   First semester

  • 応用生命化学発展実験

    2021.4 - 2021.9   First semester

  • 基礎生化学

    2021.4 - 2021.9   First semester

  • 生物化学

    2020.10 - 2021.3   Second semester

  • 専門英語

    2020.10 - 2021.3   Second semester

  • 生物化学

    2020.10 - 2021.3   Second semester

  • 生物物理化学特論

    2020.10 - 2020.12   Fall quarter

  • 構造生物学特論

    2020.10 - 2020.12   Fall quarter

  • Life Engineering, Advanced Course Ⅹ

    2020.10 - 2020.12   Fall quarter

  • 分析化学実験

    2020.4 - 2021.3   Full year

  • 応用生命化学実験

    2020.4 - 2021.3   Full year

  • 科学英語

    2020.4 - 2021.3   Full year

  • 生物物理化学

    2020.4 - 2020.9   First semester

  • 基礎生化学

    2020.4 - 2020.9   First semester

  • 応用生命化学発展実験

    2020.4 - 2020.9   First semester

  • 生物機能分子化学Ⅱ

    2020.4 - 2020.9   First semester

  • 生物機能分子化学プロジェクト演習

    2020.4 - 2020.9   First semester

  • 生物物理化学特論

    2020.4 - 2020.9   First semester

  • 基礎生化学

    2020.4 - 2020.9   First semester

  • 生物物理化学

    2020.4 - 2020.9   First semester

  • 生物化学

    2019.10 - 2020.3   Second semester

  • 応用生命化学発展実験

    2019.10 - 2020.3   Second semester

  • 学術英語3・個別テーマ

    2019.10 - 2020.3   Second semester

  • 生物化学

    2019.10 - 2020.3   Second semester

  • 構造生物学特論

    2019.10 - 2019.12   Fall quarter

  • 生物物理化学特論

    2019.10 - 2019.12   Fall quarter

  • 酵素化学特論

    2019.10 - 2019.12   Fall quarter

  • Life Engineering, Advanced Course Ⅹ

    2019.10 - 2019.12   Fall quarter

  • 応用生命化学実験

    2019.4 - 2020.3   Full year

  • 卒業研究(応用生命化学分野)

    2019.4 - 2020.3   Full year

  • 分析化学実験

    2019.4 - 2020.3   Full year

  • 科学英語

    2019.4 - 2020.3   Full year

  • 実地見学

    2019.4 - 2020.3   Full year

  • 応用生命化学発展実験

    2019.4 - 2020.3   Full year

  • 応用生命化学実験

    2019.4 - 2019.9   First semester

  • 生物物理化学

    2019.4 - 2019.9   First semester

  • 実地見学(応用生命化学分野)

    2019.4 - 2019.9   First semester

  • 科学英語(応用生命化学分野)

    2019.4 - 2019.9   First semester

  • 基礎生化学

    2019.4 - 2019.9   First semester

  • 生物物理化学特論

    2019.4 - 2019.9   First semester

  • 生物機能分子化学プロジェクト演習

    2019.4 - 2019.9   First semester

  • 生物機能分子化学Ⅱ

    2019.4 - 2019.9   First semester

  • 応用生命化学発展実験

    2019.4 - 2019.9   First semester

  • 基礎生化学

    2019.4 - 2019.9   First semester

  • 生物物理化学

    2019.4 - 2019.9   First semester

  • 生物化学実験

    2018.10 - 2019.3   Second semester

  • 生物化学

    2018.10 - 2019.3   Second semester

  • 生物化学

    2018.10 - 2019.3   Second semester

  • 生物物理化学特論

    2018.10 - 2018.12   Fall quarter

  • 構造生物学特論

    2018.10 - 2018.12   Fall quarter

  • 生体高分子学特論

    2018.4 - 2018.9   First semester

  • 基礎生化学

    2018.4 - 2018.9   First semester

  • 生物物理化学

    2018.4 - 2018.9   First semester

  • 基礎生化学

    2018.4 - 2018.9   First semester

  • 生物物理化学

    2018.4 - 2018.9   First semester

  • 生物化学

    2017.10 - 2018.3   Second semester

  • 生物化学

    2017.10 - 2018.3   Second semester

  • 酵素化学特論

    2017.10 - 2018.3   Second semester

  • 生体高分子学特論

    2017.10 - 2018.3   Second semester

  • 生物化学実験

    2017.10 - 2018.3   Second semester

  • 構造生物学特論

    2017.10 - 2017.12   Fall quarter

  • 修士論文

    2017.4 - 2018.3   Full year

  • 生物機能分子化学プロジェクト演習

    2017.4 - 2018.3   Full year

  • 生物機能分子化学特別研究第一

    2017.4 - 2018.3   Full year

  • 生物機能分子化学特別研究第二

    2017.4 - 2018.3   Full year

  • 生物物理化学

    2017.4 - 2017.9   First semester

  • 生物物理化学

    2017.4 - 2017.9   First semester

  • 基礎生化学

    2017.4 - 2017.9   First semester

  • 蛋白質化学特論

    2017.4 - 2017.9   First semester

  • 生体高分子学特論

    2017.4 - 2017.9   First semester

  • 基礎生化学

    2017.4 - 2017.9   First semester

  • 生物化学

    2016.10 - 2017.3   Second semester

  • 生物化学実験

    2016.10 - 2017.3   Second semester

  • 基礎生化学

    2016.4 - 2016.9   First semester

  • 生物物理化学

    2016.4 - 2016.9   First semester

  • 生体高分子学特論

    2016.4 - 2016.9   First semester

  • 応用生物科学概要

    2016.4 - 2016.9   First semester

  • 蛋白質化学特論

    2016.4 - 2016.9   First semester

  • Molecular Biology

    2016.4 - 2016.9   First semester

  • 生物化学

    2015.10 - 2016.3   Second semester

  • 応用生物科学概要

    2015.10 - 2016.3   Second semester

  • 生物化学実験

    2015.10 - 2016.3   Second semester

  • 基礎生化学

    2015.4 - 2015.9   First semester

  • 生体高分子学特論

    2015.4 - 2015.9   First semester

  • 応用生物科学概要

    2015.4 - 2015.9   First semester

  • 蛋白質化学特論

    2015.4 - 2015.9   First semester

  • Molecular Biology

    2015.4 - 2015.9   First semester

  • 生物化学

    2014.10 - 2015.3   Second semester

  • 応用生物科学概要

    2014.10 - 2015.3   Second semester

  • 生物化学実験

    2014.10 - 2015.3   Second semester

  • 基礎化学B

    2014.4 - 2014.9   First semester

  • 生体高分子学特論

    2014.4 - 2014.9   First semester

  • 応用生物科学概要

    2014.4 - 2014.9   First semester

  • 蛋白質化学特論

    2014.4 - 2014.9   First semester

  • Molecular Biology

    2014.4 - 2014.9   First semester

  • 応用生物科学概要

    2013.10 - 2014.3   Second semester

  • 生物化学

    2013.10 - 2014.3   Second semester

  • 生物化学実験

    2013.10 - 2014.3   Second semester

  • 生体高分子学特論

    2013.4 - 2013.9   First semester

  • 基礎化学B

    2013.4 - 2013.9   First semester

  • Molecular Biology

    2013.4 - 2013.9   First semester

  • 蛋白質化学特論

    2013.4 - 2013.9   First semester

  • 応用生物科学概要

    2013.4 - 2013.9   First semester

  • 応用生物科学概要

    2012.10 - 2013.3   Second semester

  • 生物化学

    2012.10 - 2013.3   Second semester

  • 生物化学実験

    2012.10 - 2013.3   Second semester

  • 応用生物科学概要

    2012.4 - 2012.9   First semester

  • 基礎化学B

    2012.4 - 2012.9   First semester

  • 生体高分子学特論

    2012.4 - 2012.9   First semester

  • 生物化学

    2011.10 - 2012.3   Second semester

  • 生物化学実験

    2011.10 - 2012.3   Second semester

  • 生体高分子学特論

    2011.4 - 2011.9   First semester

  • 基礎化学B

    2011.4 - 2011.9   First semester

  • 生物化学実験

    2010.10 - 2011.3   Second semester

  • 生物化学

    2010.10 - 2011.3   Second semester

  • 生体高分子学特論

    2010.4 - 2010.9   First semester

  • 生物化学実験

    2009.10 - 2010.3   Second semester

  • 生物化学

    2009.10 - 2010.3   Second semester

  • コアセミナー

    2009.4 - 2009.9   First semester

  • 生物化学実験

    2008.10 - 2009.3   Second semester

  • 生物化学

    2008.10 - 2009.3   Second semester

  • 生体高分子学特論

    2008.4 - 2008.9   First semester

  • 生物化学実験

    2007.10 - 2008.3   Second semester

  • 生物化学

    2007.10 - 2008.3   Second semester

  • 生体高分子特論

    2007.10 - 2008.3   Second semester

  • 生物化学

    2006.10 - 2007.3   Second semester

  • コアセミナー

    2006.4 - 2006.9   First semester

  • 蛋白質構造論

    2006.4 - 2006.9   First semester

  • 生物化学

    2005.10 - 2006.3   Second semester

  • 生物化学

    2004.10 - 2005.3   Second semester

  • 生物化学

    2003.10 - 2004.3   Second semester

  • 生物化学

    2002.10 - 2003.3   Second semester

▼display all

FD Participation

  • 2021.3   Role:Speech   Title:FD講演会「九州大学オンライン授業のグッドプラクティス 〜 リアルタイム型授業編〜」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.12   Role:Participation   Title:大学の研究評価の現状と農学研究院の「部局独自の評価基準」案における業績分析

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.8   Role:Participation   Title:FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2006.9   Role:Participation   Title:不明

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2006.6   Role:Participation   Title:不明

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2003.7   Role:Participation   Title:不明

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2002.12   Role:Participation   Title:不明

    Organizer:[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2018  長崎大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

Social Activities

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(QFC‐SP)」

    2024.4

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 模擬講義「タンパク質・酵素の立体構造解析からわかること」

    大分県立上野丘高校  2023.12

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(QFC‐SP)」

    2023.4

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(QFC‐SP)」

    2022.4

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(QFC‐SP)」

    2021.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(QFC‐SP)」

    2020.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 出張講義

    西南学院高等学校  2019.11

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(QFC‐SP)」

    2019.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(FC‐SP)」

    2018.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(FC‐SP)」

    2017.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 九州大学「世界に羽ばたく未来創成科学者育成プロジェクト(FC‐SP)」

    2016.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 夏の学校

    高等学校の生物及び化学の教諭対象  2016.6

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • スーパーサイエンスハイスクール事業における蛋白質結晶学実験

    修猷館高校  2006.7

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 高校生受入プログラム

    長崎東高校  2005.7

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 高校生のための科学講演会

    都城市  2003.11

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 秋の学校(バイオインフォマティクス)

    高等学校の生物及び化学の教諭対象  2003.10

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

▼display all

Media Coverage

  • マダニのたんぱく質、血の凝固を抑える仕組み解明 Newspaper, magazine

    日本経済新聞  2024.2

     More details

    マダニのたんぱく質、血の凝固を抑える仕組み解明

  • チロシン硫酸転移酵素のメカニズム解明 Newspaper, magazine

    NHK、日本経済新聞、朝日新聞、西日本新聞、秋田魁新報、宮崎日日新聞、静岡新聞  2013.3

     More details

    チロシン硫酸転移酵素のメカニズム解明

Travel Abroad

  • 2017.3

    Staying countory name 1:United States   Staying institution name 1:ハワイ大学

  • 2016.3

    Staying countory name 1:United States   Staying institution name 1:ハワイ大学

  • 2015.3

    Staying countory name 1:United States   Staying institution name 1:ハワイ大学

  • 2014.8

    Staying countory name 1:United States   Staying institution name 1:トレド大学とNIEHS/NIH

  • 2014.3

    Staying countory name 1:United States   Staying institution name 1:ハワイ大学

  • 2013.3

    Staying countory name 1:Philippines   Staying institution name 1:アテネオ・デ・マニラ大学

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