Crystal structure of mango α1,3/α1,4-fucosyltransferase elucidates unique elements that regulate Lewis a-dominant oligosaccharide assembly Reviewed International journal

Takahiro Okada, Takamasa Teramoto, Hideyuki Ihara, Yoshitaka Ikeda, Yoshimitsu Kakuta

Glycobiology   2024.2

Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of the tick anticoagulant protein madanin Reviewed International journal

Misa Yoshimura, Takamasa Teramoto, Hirai Asano, Yuka Iwamoto, Mariko Kondo, Etsuko Nishimoto, Yoshimitsu Kakuta

J Biol Chem.   2024.2

Disassembly and reassembly of the non-conventional thermophilic C-phycocyanin Reviewed International journal

Hung Khac Nguyen, Takuo Minato, Takamasa Teramoto, Seiji Ogo, Yoshimitsu Kakuta, Ki-Seok Yoon

Journal of Bioscience and Bioengineering   2024.1

Non-conventional octameric structure of C-phycocyanin Reviewed International journal

Takuo Minato, Takamasa Teramoto, Naruhiko Adachi, Nguyen Khac Hung, Kaho Yamada, Masato Kawasaki, Masato Akutsu, Toshio Moriya, Toshiya Senda, Seiji Ogo, Yoshimitsu Kakuta, Ki-Seok Yoon

Communications biology   4 ( Article number: 1238 )   2021.10

Minimal protein-only RNase P structure reveals insights into tRNA precursor recognition and catalysis Reviewed International journal

@Takamasa Teramoto, #Takeshi Koyasu, @Naruhiko Adachi, @Masato Kawasaki, @Toshio Moriya, @Tomoyuki Numata, @Toshiya Senda, @Yoshimitsu Kakuta

The Journal of Biological Chemistry   297 ( 3 )   2021.9

Structural Insight Into the Recognition of Pathogen-Derived Phosphoglycolipids by C-type Lectin Receptor DCAR Reviewed International journal

Zakaria Omahdi, #Yuto Horikawa, Masamichi Nagae, Kenji Toyonaga, Akihiro Imamura, Koichi Takato, Takamasa Teramoto, Hideharu Ishida, Yoshimitsu Kakuta, Sho Yamasaki

The Journal of Biological Chemistry   2020.3

Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1. Reviewed International journal

Tanaka S, Nishiyori T, Kojo H, Otsubo R, Tsuruta M, Kurogi K, Liu MC, Suiko M, Sakakibara Y, Kakuta Y

Scientific Reports   2017.8

A rationally engineered yeast pyruvyltransferase Pvg1p introduces sialylation-like properties in neo-human-type complex oligosaccharide. Reviewed International journal

Yujiro Higuchi, Yoshinaga S, Tateno H, Hirabaysshi J, Nakakita S, Kenakiyo M, Kakuta Y, Takegawa K

Scientific Reports   ( 6 )   2016.5

The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein Reviewed International journal

Kawaguchi Y, Sugiura N, Kimata K, Kimura M, Kakuta Y

FEBS Letters   2013.12

Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction Reviewed International journal

Teramoto T, Fujikawa Y, Kawaguchi Y, Kurogi K, Soejima M, Adachi R, Nakanishi Y, Mishiro-Sato E, Liu MC, Sakakibara Y, Suiko M, Kimura M, Kakuta Y

Nature Communications   2013.3

Glucuronyltransferase activity of KfiC from Escherichia coli strain K5 requires association of KfiA: KfiC and KfiA are essential enzymes for production of K5 polysaccharide, N-acetylheparosan. Reviewed International journal

Sugiura N, Baba Y, Kawaguchi Y, Iwatani T, Suzuki K, Kusakabe T, Yamagishi K, Kimata K, Kakuta Y, Watanabe H.

The Journal of Biological Chemistry   285 ( 3 )   2010.1

On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases. Reviewed International journal

Teramoto T, Adachi R, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y.

FEBS Lett.   2009.9

Snapshot of a Michaelis complex in a sulfuryl transfer reaction: Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate. Reviewed International journal

Teramoto T, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y.

Biochem Biophys Res Commun.   2009.5

Structural basis for the broad range substrate specificity of a novel mouse cytosolic sulfotransferase--mSULT1D1. Reviewed International journal

Teramoto T, Sakakibara Y, Liu MC, Suiko M, Kimura M, Kakuta Y.

Biochem Biophys Res Commun.   2009.1

Crystal structure of chondroitin polymerase from Escherichia coli K4. Reviewed International journal

Osawa T, Sugiura N, Shimada H, Hirooka R, Tsuji A, Shirakawa T, Fukuyama K, Kimura M, Kimata K, Kakuta Y.

Biochem Biophys Res Commun.   2009.1

Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. Reviewed International journal

Takagi H, Kakuta Y, Okada T, Yao M, Tanaka I, Kimura M.

Nature structural & molecular biology   12 ( 4 )   327 - 331   2005.4

Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution. Reviewed International journal

Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y.

The Journal of Molecular Biology   345 ( 5 )   1111 - 1118   2005.2

The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Reviewed International journal

Yamagata A., Kakuta Y., Masui R., Fukuyama K.

Proceedings of the National Academy of Sciences of the United States of America.   2002.4

Crystal structure of sulfotransferase domain of human heparan sulfate N-deacetylase/N-sulfotransferase 1. Reviewed International journal

Kakuta, Y., Sueyoshi, T., Negishi, M., and Pedersen, L.C.

The Journal of Biological Chemistry   1999.1

Conserved structural motifs of the sulfotransferase family. Reviewed International journal

Kakuta, Y., Pedersen, L.C., Pedersen, L.G., and Negishi, M.

Trends in Biochemical Sciences   1998.1

Crystal structure of estrogen sulphotransferase. Reviewed International journal

Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC.

Nature structural biology   1997.11

Taste receptor type 1 member 3 in osteoclasts regulates osteoclastogenesis via detection of glucose

Yoshimura, A; Matsubara, T; Kodama, N; Kakuta, Y; Yasuda, K; Yoshida, R; Kaminuma, O; Hosomi, S; Shinkawa, H; Yuan, Q; Kawamoto, T; Kokabu, S

JOURNAL OF BIOLOGICAL CHEMISTRY   301 ( 3 )   108273   2025.3   （ ISSN:00219258 eISSN:1083-351X ）

KIF22 regulates mitosis and proliferation of chondrocyte cells

Kawaue, H; Matsubara, T; Nagano, K; Ikedo, A; Rojasawasthien, T; Yoshimura, A; Nakatomi, C; Imai, Y; Kakuta, Y; Addison, WN; Kokabu, S

ISCIENCE   27 ( 7 )   110151   2024.7   （ eISSN:2589-0042 ）

Orthogonality of α-Sulfoquinovosidase in Human Cells and Development of Its Fluorescent Substrate

Yoshida, R; Kaguma, R; Kaneko, R; Matsuo, I; Yoritate, M; Hirai, G; Teramoto, T; Kakuta, Y; Minamihata, K; Kamiya, N; Nii, T; Kishimura, A; Mori, T; Katayama, Y

SENSORS AND MATERIALS   36 ( 8 )   3227 - 3238   2024   （ ISSN:0914-4935 ）

Crystal structure of<i> Arabidopsis</i><i> thaliana</i> sulfotransferase SOT16 involved in glucosinolate biosynthesis

Iwamoto, Y; Saito, S; Teramoto, T; Maruyama-Nakashita, A; Kakuta, Y

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   677   149 - 154   2023.10   （ ISSN:0006-291X eISSN:1090-2104 ）

Crystal structure of Arabidopsis thaliana sulfotransferase SOT16 involved in glucosinolate biosynthesis Reviewed International journal

#Yuka Iwamoto, @Seira Saito, @Takamasa Teramoto, @Akiko Maruyama-Nakashita, @Yoshimitsu Kakuta

Biochemical and Biophysical Research Communications   677   149 - 154   2023.10

Crystal structure of a unique activating sulfotransferase SgdX2 involved in the sungeidine biosynthesis

Mori, T; Teramoto, T; Kakuta, Y

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES   79   C847 - C847   2023.8   （ ISSN:2053-2733 ）

Crystal structure of adenosine 5'-phosphosulfate kinase isolated from Archaeoglobus fulgidus Reviewed International journal

#Tomoya Kawakami, @Takamasa Teramoto, @Yoshimitsu Kakuta

Biochemical and Biophysical Research Communications   643   105 - 110   2023.2

The crystal structure of mouse SULT2A8 reveals the mechanism of 7α-hydroxyl, bile acid sulfation Reviewed International journal

Takamasa Teramoto, #Takeaki Nishio, Katsuhisa Kurogi, Yoichi Sakakibara, Yoshimitsu Kakuta

Biochemical and Biophysical Research Communications   562   15 - 20   2021.7

Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA Reviewed International journal

Takamasa Teramoto, Kipchumba J Kaitany, Yoshimitsu Kakuta, Makoto Kimura, Carol A Fierke, Traci M Tanaka Hall

Nucleic Acids Res   48 ( 21 )   11815 - 11826   2020.12

Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites Reviewed International journal

Minato, Takuo; Teramoto, Takamasa; Kakuta, Yoshimitsu; Ogo, Seiji; Yoon, Ki-Seok

FEBS Open Bio   2020.3

Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ Reviewed International journal

Keitaro Suyama, Shuhei Kaneko, Hitoshi Kesamaru, Xiaohui Liu, Ayami Matsushima, Yoshimitsu Kakuta, Takashi Okubo, Kazumi Kasatani, Takeru Nose

Chemical Research in Toxicology   2020.2

Functional implication of archaeal homologues of human RNase P protein pair Pop5 and Rpp30. Reviewed International journal

Hamasaki M, Hazeyama K, Iwasaki F, Ueda T, Nakashima T, Kakuta Y, Kimura M

Journal of Biochemistry   159 ( 1 )   31 - 40   2016.1

Mutation of the gene encoding the ribonuclease P RNA in the hyperthermophilic archaeon Thermococcus kodakarensis causes decreased growth rate and impaired process. Reviewed International journal

Ueda T, Ishino S, Suematsu K, Nakashima T, Kakuta Y, Kimura M

Biochem Biophys Res Commun.   468 ( 4 )   660 - 665   2015.12

Archaeal ribonuclease P proteins have potential for biotechnological applications where precise hybridization of nucleic acids is needed. Reviewed International journal

Miyanoshita M, Nakashima T, Kakuta Y, Kimura M

Biosci Biotechnol Biochem.   79 ( 12 )   2014 - 2017   2015.6

On archaeal homologs of the human RNase P proteins Pop5 and Rpp30 in the hyperthermophilic archaeon Thermococcus kodakarensis. Reviewed International journal

Suematsu K, Ueda T, Nakashima T, Kakuta Y, Kimura M

Biosci Biotechnol Biochem.   2015.2

Enhancement of RNA annealing and strand displacement found in archaeal ribonuclease P proteins is conserved in Escherichia coli protein C5 and yeast protein Rpr2 Reviewed International journal

Furutani T, Hazeyama K, Ueda T, Tomita S, Imai T, Gao X, Nakashima T, Kakuta Y, Kimura M

Biosci Biotechnol Biochem.   2014.10

Characterization of putative toxin/antitoxin systems in Vibrio parahaemolyticus. Reviewed International journal

Hino M, Zhang J, Takagi H, Miyoshi T, UchiumiT, Nakashima T, Kakuta Y, Kimura M

J Appl Microbiol.   2014.9

Pentatricopeptide repeat motifs in the processing enzyme PRORP1 in Arabidopsis thaliana play a crucial role in recognition of nucleotide bases at TψC loop in precursor tRNAs Reviewed International journal

Imai T, Nakamura T, Maeda T, Nakayama K, Gao X, Nakashima T, Kakuta Y, Kimura M

Biochem Biophys Res Commun   2014.8

Tamavidin 2-HOT, a highly thermostable biotin-binding protein Reviewed International journal

Takakura Y, Suzuki J, Oka N, Kakuta Y

Journal of Biotechnology   2014.1

Characterization of the peripheral structures of archaeal RNase P RNA from Pyrococcus horikoshii OT3 Reviewed International journal

Ueda T, Yamaguchi H, Miyanoshita M, Nakashima T, Kakuta Y, Kimura M

The Journal of Biochemistry   2014.1

Extra-structural elements in the RNA recognition motif in archaeal Pop5 play a crucial role in the activation of RNase P RNA from Pyrococcus horikoshii OT3 Reviewed International journal

Hazeyama K, Ishihara M, Ueda T, Nishimoto E, Nakashima T, Kakuta Y, Kimura M

Biochemical and Biophysical Research Communications   2013.11

A distinct binding mode of archaeal ribonuclease P proteins to RNA Reviewed International journal

Ishihara M, Nishimoto E, Yamashita S, Kakuta Y, Kimura M

Biosci Biotechnol Biochem. 76(12):2335-7.   2012.12

Single-molecular enzymatic elongation of hyaluronan polymers visualized by high-speed atomic force microscopy Reviewed International journal

Mori T, Hirose A, Hagiwara T, Ohtsuka M, Kakuta Y, Kimata K, Okahata Y

J Am Chem Soc. 134(50):20254-7.   2012.12

The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis. Reviewed International journal

Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M

J Biol Chem. 287(43):36022-8.   2012.10

Structural basis for catalytic activity of a silkworm Delta-class glutathione transferase Reviewed International journal

Yamamoto K, Usuda K, Kakuta Y, Kimura M, Higashiura A, Nakagawa A, Aso Y, Suzuki M

Biochim Biophys Acta. 2012 Oct;1820(10):1469-74.   2012.10

Loss-of-function mutation in bi-functional marine bacterial sialyltransferase Reviewed International journal

Kajiwara H, Katayama S, Kakuta Y, Okino N, Ito M, Mine T, Yamamoto T

Biosci Biotechnol Biochem. 2012;76(9):1639-44.   2012.9

Crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose Reviewed International journal

Chaen K, Noguchi J, Omori T, Kakuta Y, Kimura M

Biochem Biophys Res Commun. 2012 424(3):508-11.   2012.8

Kinetics of iterative carbohydrate transfer to polysaccharide catalyzed by chondroitin polymerase on a highly sensitive flow-type 27 MHz quartz-crystal microbalance Reviewed International journal

Mori T, Kodera T, Yoshimine H, Kakuta Y, Sugiura N, Kimata K, Okahata Y

Chemistry. 2012 ;18(24):7388-93.   2012.6

Thermodynamic analysis of a multifunctional RNA-binding protein, PhoRpp38, in the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

Oshima K, Nakashima T, Kakuta Y, Tsumoto K, Kimura M

Biosci Biotechnol Biochem. 2012;76(6):1252-5.   2012.6

Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66. Reviewed International journal

Kawaguchi Y, Sugiura N, Onishi M, Kimata K, Kimura M, and Kakuta Y.

Acta. Crystallogr. Sect F   68   2012.2

Crystal structure of sulfotransferase STF9 from Mycobacterium avium. Reviewed International journal

Hossain MM, Moriizumi Y, Tanaka S, Kimura M, Kakuta Y.

Mol Cell Biochem.   ( 361 )   2012.2

Structural modeling of RNase P RNA from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

Zwieb C, Nakao Y, Nakashima H, Takagi H, Goda S, Andersen E.S, Kakuta Y, and Kimura M.

Biochem Biophys Res Commun.   in press   2011.10

Molecular cloning, expression, and functional analysis of a predicted sulfotransferase STF9 from Mycobacterium avium. Reviewed International journal

Hossain MM, Moriizumi Y, Tanaka S, Kimura M, Kakuta Y.

Mol Cell Biochem.   350 ( (1-2) )   2011.10

Crystallographic survey of active sites of an unclassified glutathione transferase from Bombyx mori.

Kakuta Y, Usuda K, Nakashima T, Kimura M, Aso Y, Yamamoto K.

Biochim Biophys Acta.   in press   2011.7

The Contribution of Peripheral Stem-Loops to the Catalytic Activity of Archaeal RNase P RNA from Pyrococcus horikoshii OT3. Reviewed International journal

Hara T, Terada A, Yamaguchi H, Nakashima T, Kakuta Y, Kimura M.

Biosci Biotechnol Biochem.   75(4)   2011.5

Crystal structure of the branching enzyme I (BEI) from Oryza sativa L with implications for catalysis and substrate binding. Reviewed International journal

Noguchi J, Chaen K, Vu NT, Akasaka T, Shimada H, Nakashima T, Nishi A, Satoh H, Omori T, Kakuta Y, Kimura M.

Glycobiology   ( 8 )   2011.4

The structural mechanism of the inhibition of archaeal RelE toxin by its cognate RelB antitoxin. Reviewed International journal

Shinohara M, Guo JX, Mori M, Nakashima T, Takagi H, Nishimoto E, Yamashita S, Tsumoto K, Kakuta Y, Kimura M.

Biochem Biophys Res Commun.   400   2010.9

Structure of the newly found green turtle egg-white ribonuclease. Reviewed International journal

Katekaew S, Kuaprasert B, Torikata T, Kakuta Y, Kimura M, Yoneda K, Araki T.

Acta. Crystallogr. Sect F   66   2010.6

Zebrafish as a model for the study of the phase II cytosolic sulfotransferases. Reviewed International journal

Liu TA, Bhuiyan S, Liu MY, Sugahara T, Sakakibara Y, Suiko M, Yasuda S, Kakuta Y, Kimura M, Williams FE, Liu MC.

Curr. Drug Metab.   6   2010.6

Expression and functional analysis of a predicted AtsG arylsulfatase identified from Mycobacterium tuberculosis genomic data. Reviewed International journal

Hossain MM, Kawarabayasi Y, Kimura M, Kakuta Y.

J Biochem.   146 ( 6 )   2009.12

Crystal structure of alpha/beta-galactoside alpha2,3-sialyltransferase from a luminous marine bacterium, Photobacterium phosphoreum Reviewed International journal

Iwatani T, Okino N, Sakakura M, Kajiwara H, Takakura Y, Kimura M, Ito M, Yamamoto T, Kakuta Y.

FEBS Lett.   2009.6

Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. Reviewed International journal

Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M.

J Biol Chem.   2009.4

Tamavidins--novel avidin-like biotin-binding proteins from the Tamogitake mushroom. Reviewed International journal

Takakura Y, Tsunashima M, Suzuki J, Usami S, Kakuta Y, Okino N, Ito M, Yamamoto T.

FEBS J.   2009.3

Structure of an archaeal homolog of the human protein complex Rpp21-Rpp29 that is a key core component for the assembly of active ribonuclease P. Reviewed International journal

Honda T, Kakuta Y, Kimura K, Saho J, Kimura M.

J Mol Biol.   2008.12

Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus. Reviewed International journal

Satone H, Oshima Y, Shimasaki Y, Tawaratsumida T, Oba Y, Takahashi E, Kitano T, Kawabata S, Kakuta Y, Honjo T.

Aquat Toxicol.   2008.12

Biochemical and Crystallographic Characterization of the Starch Branching Enzyme I (BEI) from Oryza sativa L. Reviewed International journal

Vu NT, Shimada H, Kakuta Y, Nakashima T, Ida H, Omori T, Nishi A, Satoh H, Kimura M.

Biosci Biotechnol Biochem.   2008.11

Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase. Reviewed International journal

Teramoto T, Sakakibara Y, Inada K, Kurogi K, Liu MC, Suiko M, Kimura M, Kakuta Y.

FEBS Lett.   2008.11

The Chondroitin Polymerase K4CP and the Molecular Mechanism of Selective Bindings of Donor Substrates to Two Active Sites. Reviewed International journal

Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M.

J Biol Chem.   2008.11

Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase Reviewed International journal

Noguchi J, Hayashi Y, Baba Y, Okino N, Kimura M, Ito M, Kakuta Y.

Biochem Biophys Res Commun.   2008.9

ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner. Reviewed

Matsushima A, Teramoto T, Okada H, Liu X, Tokunaga T, Kakuta Y, Shimohigashi Y.

Biochem Biophys Res Commun.   2008.8

Crystal structure and functional analysis of an archaeal chromatin protein Alba from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

Hada K, Nakashima T, Osawa T, Shimada H, Kakuta Y, Kimura M.

Biosci Biotechnol Biochem.   2008.3

Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha-2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition. Reviewed International journal

Kakuta Y, Okino N, Kajiwara H, Ichikawa M, Takakura Y,Ito M, Yamamoto T

Glycobiology   2008.1

Crystal structure of an archaeal Ski2p-like protein from Pyrococcus horikoshii OT3. Reviewed International journal

Zhang X, Nakashima T, Kakuta Y, Yao M, Tanaka I, Kimura M.

Protein Sci.   2008.1

Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR{gamma} Reviewed International journal

Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata SI, Kimura M, Shimohigashi Y.

J Biochem (Tokyo)   2007.10

Klotho-related Protein Is a Novel Cytosolic Neutral beta-Glycosylceramidase. Reviewed International journal

Hayashi Y, Okino N, Kakuta Y, Shikanai T, Tani M, Narimatsu H, Ito M.

J Biol Chem.   2007.10

Crystal Structure of Tapes japonica Lysozyme with Substrate Analogue: STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND MANIFESTATION OF ITS CHITINASE ACTIVITY ACCOMPANIED BY QUATERNARY STRUCTURAL CHANGE. Reviewed International journal

Goto T, Abe Y, Kakuta Y, Takeshita K, Imoto T, Ueda T.

J Biol Chem.   2007.9

Purification, crystallization and preliminary crystallographic characterization of the alpha 2,6-sialyltransferase from Photobacterium sp. JT-ISH-224. Reviewed International journal

Okino N, Kakuta Y, Kajiwara H, Ichikawa M, Takakura Y, Ito M, Yamamoto T.

Acta Crystallogr Sect F Struct Biol Cryst Commun.   2007.8

Crystal structures of the Nicotiana glutinosa ribonuclease NT in complex with nucleoside monophosphates. Reviewed International journal

Kawano S, Kakuta Y, Nakashima T, Kimura M.

J Biochem (Tokyo).   2006.9

A fifth protein subunit Ph1496p elevates the optimum temperature for the ribonuclease P activity from Pyrococcus horikoshii OT3 Reviewed International journal

Fukuhara H, Kifusa M, Watanabe M, Terada A, Honda T, Numata T, Kakuta Y, Kimura M.

J Biochem (Tokyo)   2006.5

Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme Reviewed International journal

Kawano S, Nakashima T, Kakuta Y, Tanaka I, Kimura M

J. Mol Biol.   2006.3

Crystal Structure of a Ribonuclease P Protein Ph1601p from Pyrococcus horikoshii OT3: An Archaeal Homologue of Human Nuclear Ribonuclease P Protein Rpp21 Reviewed International journal

Kakuta Y, Ishimatsu I, Numata T, Kimura K, Yao M, Tanaka I, Kimura M.

Biochemistry   44 ( 36 )   12086 - 12093   2005.9

Crystal structure of Escherichia coli YfhJ protein, a member of the ISC machinery involved in assembly of iron-sulfur clusters. Reviewed International journal

Shimomura Y, Takahashi Y, Kakuta Y, Fukuyama K.

Proteins.   60 ( 3 )   566 - 569   2005.8

Overproduction, purification and preliminary X-ray diffraction analysis of a sulfotransferase from Mycobacterium tuberculosis H37Rv. Reviewed International journal

Tanaka S, Moriizumi Y, Kimura M, Kakuta Y.

Acta Crystallograph Sect F Struct Biol Cryst Commun.   61   33 - 35   2005.1

Crystal structure of archaeal ribonuclease P protein Ph1771p from Pyrococcus horikoshii OT3: an archaeal homolog of eukaryotic ribonuclease P protein Rpp29. Reviewed International journal

Numata T, Ishimatsu I, Kakuta Y, Tanaka I, Kimura M.

RNA.   10 ( 9 )   1423 - 1432   2004.9

Amino acids conserved at the C-terminal half of the ribonuclease T2 family contribute to protein stability of the enzymes. Reviewed International journal

Kimura K, Numata T, Kakuta Y, Kimura M.

Biosci Biotechnol Biochem.   68 ( 8 )   1748 - 1757   2004.8

Crystal structure of the regulatory subunit of archaeal initiation factor 2B (aIF2B) from hyperthermophilic archaeon Pyrococcus horikoshii OT3: a proposed structure of the regulatory subcomplex of eukaryotic IF2B Reviewed International journal

Kakuta Y, Tahara M, Maetani S, Yao M, Tanaka I, Kimura M.

Biochem. Biophys. Res. Commun   319 ( 3 )   725 - 732   2004.7

Crystal structure of the ribonuclease P protein Ph1877p from hyperthermophilic archaeon Pyrococcus horikoshii OT3. Reviewed International journal

Takagi H, Watanabe M, Kakuta Y, Kamachi R, Numata T, Tanaka I, Kimura M.

Biochem Biophys Res Commun.   319 ( 3 )   787 - 794   2004.7

Overproduction, crystallization and preliminary X-ray diffraction analysis of probable ATP sulfurylase from Thermus thermophilus HB8 Reviewed International journal

Taguchi Y, Hoseki J, Kakuta Y, Fukuyama K.

Acta. Crystallogr. D   2003.9

Crystal Structures of the Quinone Oxidoreductase from Thermus thermophilus HB8 and Its Complex with NADPH: Implication for NADPH and Substrate Recognition Reviewed International journal

Shimomura Y, Kakuta Y, Fukuyama K.

J. Bacteriol.   185 ( 14 )   4211 - 4218   2003.7

Crystal Structures of the Ribonuclease MC1 Mutants N71T and N71S in Complex with 5’-GMP: Structural Basis for Alterations in Substrate Specificity Reviewed International journal

Numata T, Suzuki A, Kakuta Y, Kimura K, Yao M, Tanaka I, Yoshida Y, Ueda T, Kimura M.

Biochemistry   42 ( 18 )   5270 - 5278   2003.5

Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition Reviewed International journal

Kakuta Y, Li L, Pedersen LC, Pedersen LG, Negishi M.

Biochem. Soc. Trans   2003.4

Atomic resolution structures of oxidized [4Fe-4S] ferredoxin from Bacillus thermoproteolyticus in two crystal forms: systematic distortion of [4Fe-4S] cluster in the protein. Reviewed International journal

Fukuyama K., Okada T., Kakuta Y., Takahashi Y.

Journal of Molecular Biology   2002.1

Crystal Structure of Rat Apo-Heme Oxygenase-1 (HO-1): Mechanism of Heme Binding in HO-1 Inferred from Structural Comparison of the Apo and Heme Complex Forms. Reviewed International journal

Sugishima M., Sakamoto H., Kakuta Y., Omata Y., Hayashi S., Noguchi M., Fukuyama K.

Biochemistry   2002.1

Guanine binding site of the Nicotiana glutinosa ribonuclease NW revealed by X-ray crystallography. Reviewed International journal

Kawano S., Kakuta Y., and Kimura M.

Biochemistry   41 ( 51 )   15195 - 15202   2002.1

Overexpression, purification and characterization of RecJ protein from Thermus thermophilus HB8 and its core domain. Reviewed International journal

Yamagata A., Masui R., Kakuta Y., Kuramitsu S., Fukuyama K.

Nucleic Acids Research   2001.1

Crystal structure of the Escherichia coli Fdx, an Adrenodoxin-type Ferredoxin Involved in the Assembly of Iron-Sulfur Clusers. Reviewed International journal

Kakuta Y., Horio T., Takahashi Y., and Fukuyama K.

Biochemistry   2001.1

Structure-Function Modeling of the Interactions of N-Alkyl-N-hydroxyanilines with Rat Hepatic Aryl Sulfotransferase IV. Reviewed International journal

King RS, Sharma V., Pedersen L.C., Kakuta Y., Negishi M., and Duffel MW.

Chem Res Toxicol   2000.1

Crystal structure of rat heme oxygenase-1 in complex with heme. Reviewed International journal

Sugishima M., Omata Y., Kakuta Y., Sakamoto H., Noguchi M., and Fukuyama K.

FEBS Letter   2000.1

Substrate gating confers steroid specificity to estrogen sulfotransferase. Reviewed International journal

Petrotchenko EV, Doerflein ME, Kakuta Y., Pedersen L.C., and Negishi M.

The Journal of Biological Chemistry   1999.1

3'-Phosphoadenosine 5'-phosphosulfate binding site of flavonol 3-sulfotransferase srudied by affinity chromatography and 31P NMR. Reviewed International journal

Marsolais, F., Laviolette, M., Kakuta, Y., Negishi, M., Pedersen, L.C., Auger, M., and Varin, L.

Biochemistry   1999.1

A quantum mechanical study of the transfer of biological sulfate. Reviewed International journal

Bartolotti, L., Kakuta, Y., Pedersen, L.C., Negishi, M., and Pedersen, L.G.

Theochem-Journal of Molecular Structure.   1999.1

Crystal structure of human catecholamine sulfotransferase. Reviewed International journal

Bidwell LM, McManus ME, Gaedigk A, Kakuta Y., Negishi M., Pedersen L., and Martin JL.

Journal of Molecular Biology   1999.1

A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotranferase. Reviewed International journal

Sueyoshi, T., Kakuta, Y., Pedersen, L.C., Frances, E.W., Pedersen, L.G., and Negishi, M.

FEBS Letter   1998.1

Mouse steroid sulfotransferases: substrate specificity and preliminary X-ray crystallographic analysis. Reviewed International journal

Kakuta, Y., Pedersen, L.C., Chae, K., Song, W., Leblanc, D., London, R., Carter, C.W., and Negishi, M.

Biochemical Pharmacology   1998.1

The sulfuryl transfer mechanism: Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis. Reviewed International journal

Kakuta, Y., Petrotchenko E.V., Pedersen, L.C., and Negishi, M.

The Journal of Biological Chemistry   1998.1

Glycine-15 in the bend between two alpha-helices can explain the thermostability of DNA binding protein HU from Bacillus stearothermophilus. Reviewed International journal

Kawamura S, Kakuta Y, Tanaka I, Hikichi K, Kuhara S, Yamasaki N, Kimura M.

Biochemistry.   35 ( 4 )   1195 - 1200   1996.1

1H NMR study on substituent distribution of cellulose diacetate Reviewed International journal

Hikichi, K., Kakuta, Y., and Katoh, T.

Polymer Journal   1995.1

13C-NMR relaxation study on mobility of the DNA-binding arm of HU. Reviewed International journal

Kakuta Y, Hojo H, Aimoto S, Tanaka I, Hikichi K.

J Biochem (Tokyo).   1994.11

Development of a Linker with an Enhanced Stability for the Preparation of Peptide Thioesters and Its Application to the Synthesis of Stable-Isotope-Labelled HU-Type DNA-Binding Protein Reviewed International journal

Hojo H., Kwon Y.,Kakuta Y.,Tsuda S.,Tanaka I.,Hikichi K., and Aimoto S.

Bull. Chem. Soc. Jpn   1993.9

【JBにおけるProtein Data Bank50年史】内分泌攪乱物質ビスフェノールAとエストロゲン関連受容体γの結晶構造(【50 years of Protein Data Bank in JB】Crystal structure of endocrine-disrupting chemical bisphenol A and estrogen-related receptor γ)

Matsushima Ayami, Teramoto Takamasa, Kakuta Yoshimitsu

The Journal of Biochemistry   171 ( 1 )   23 - 25   2022.1   （ ISSN:0021-924X ）

植物リボヌクレアーゼの基質認識機構

沼田　倫征、 河野　慎、 角田　佳充、 木村　誠

化学と生物   2003.1

Structure and Function of Sulfotransferases

Negishi, M., Pedersen, L.G., Petrotchenko, E., Shevtsov, S., Gorokho, A., Kakuta, Y., Pedersen, L.C.

Archives of Biochemistry and Biophysics   2001.1

スルホトランスフェラーゼの構造生物学

角田佳充、Lars C. Pedersen, 根岸 正彦

日本結晶学会誌   2000.9

日本蛋白質科学会

日本農芸化学会

日本生化学会九州支部   Organizer   Domestic

2007.11 - 2008.10   

日本農芸化学会   代議員   Domestic

2007.4 - 2008.3   

日本農芸化学会西日本支部   Organizer   Domestic

2003.1 - 2004.12   

宇宙環境を利用した高品質タンパク質結晶生成と精密立体構造の解析

2009.10 - 2010.9

Research commissions

スフィンゴ糖脂質代謝マシーナリの構造と機能及び応用に関する研究

Grant number：21380066  2009 - 2011

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

高効率な部位特異的硫酸化タンパク質生産法の開発

2009

JST　シーズ発掘試験研究

リボ核タンパク質複合体酵素の作用機構に関する研究

Grant number：19380060  2007 - 2009

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

核内受容体ERRgammaを介したビスファノールＡの低用量効果の解明

Grant number：19201012  2007 - 2009

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

硫酸転移酵素による多様な生体異物認識の立体構造基盤解明

Grant number：19570106  2007 - 2008

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

新しいエンド型・エキソ型グリコサラミダーゼの構造と機能及び応用に関する研究

Grant number：19380061  2007 - 2008

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

生物機能分子化学Ⅱ

2024.4 - 2024.9   First semester

生物機能分子化学プロジェクト演習

2024.4 - 2024.9   First semester

基礎生化学I

2024.4 - 2024.6   Spring quarter

生物物理化学I

2024.4 - 2024.6   Spring quarter

生物物理化学特論

2023.10 - 2023.12   Fall quarter

生物物理化学特論

2023.10 - 2023.12   Fall quarter

生物化学I

2023.10 - 2023.12   Fall quarter

生物物理化学Ⅱ

2023.6 - 2023.8   Summer quarter

科学英語

2023.4 - 2024.3   Full year

応用生命化学発展実験

2023.4 - 2023.9   First semester

生物機能分子化学プロジェクト演習

2023.4 - 2023.9   First semester

生物機能分子化学Ⅱ

2023.4 - 2023.9   First semester

生物物理化学Ⅰ

2023.4 - 2023.6   Spring quarter

基礎生化学Ⅰ

2023.4 - 2023.6   Spring quarter

基礎生化学I

2023.4 - 2023.6   Spring quarter

生物物理化学特論

2022.10 - 2022.12   Fall quarter

生物化学Ⅰ

2022.10 - 2022.12   Fall quarter

生物物理化学特論

2022.10 - 2022.12   Fall quarter

生物化学I

2022.10 - 2022.12   Fall quarter

生物物理化学Ⅱ

2022.6 - 2022.8   Summer quarter

科学英語

2022.4 - 2023.3   Full year

応用生命化学発展実験

2022.4 - 2022.9   First semester

生物機能分子化学プロジェクト演習

2022.4 - 2022.9   First semester

生物機能分子化学Ⅱ

2022.4 - 2022.9   First semester

生物物理化学Ⅰ

2022.4 - 2022.6   Spring quarter

基礎生化学Ⅰ

2022.4 - 2022.6   Spring quarter

基礎生化学I

2022.4 - 2022.6   Spring quarter

生物化学I

2021.10 - 2021.12   Fall quarter

生物物理化学特論

2021.10 - 2021.12   Fall quarter

生物物理化学特論

2021.10 - 2021.12   Fall quarter

生物化学Ⅰ

2021.10 - 2021.12   Fall quarter

科学英語

2021.4 - 2022.3   Full year

生物機能分子化学プロジェクト演習

2021.4 - 2021.9   First semester

応用生命化学発展実験

2021.4 - 2021.9   First semester

基礎生化学

2021.4 - 2021.9   First semester

生物機能分子化学Ⅱ

2021.4 - 2021.9   First semester

生物物理化学

2021.4 - 2021.9   First semester

基礎生化学

2021.4 - 2021.9   First semester

生物化学

2020.10 - 2021.3   Second semester

生物化学

2020.10 - 2021.3   Second semester

専門英語

2020.10 - 2021.3   Second semester

Life Engineering, Advanced Course Ⅹ

2020.10 - 2020.12   Fall quarter

生物物理化学特論

2020.10 - 2020.12   Fall quarter

構造生物学特論

2020.10 - 2020.12   Fall quarter

分析化学実験

2020.4 - 2021.3   Full year

応用生命化学実験

2020.4 - 2021.3   Full year

科学英語

2020.4 - 2021.3   Full year

生物物理化学

2020.4 - 2020.9   First semester

生物物理化学

2020.4 - 2020.9   First semester

基礎生化学

2020.4 - 2020.9   First semester

応用生命化学発展実験

2020.4 - 2020.9   First semester

生物機能分子化学Ⅱ

2020.4 - 2020.9   First semester

生物機能分子化学プロジェクト演習

2020.4 - 2020.9   First semester

生物物理化学特論

2020.4 - 2020.9   First semester

基礎生化学

2020.4 - 2020.9   First semester

生物化学

2019.10 - 2020.3   Second semester

生物化学

2019.10 - 2020.3   Second semester

応用生命化学発展実験

2019.10 - 2020.3   Second semester

学術英語３・個別テーマ

2019.10 - 2020.3   Second semester

Life Engineering, Advanced Course Ⅹ

2019.10 - 2019.12   Fall quarter

構造生物学特論

2019.10 - 2019.12   Fall quarter

生物物理化学特論

2019.10 - 2019.12   Fall quarter

酵素化学特論

2019.10 - 2019.12   Fall quarter

応用生命化学実験

2019.4 - 2020.3   Full year

卒業研究（応用生命化学分野）

2019.4 - 2020.3   Full year

分析化学実験

2019.4 - 2020.3   Full year

科学英語

2019.4 - 2020.3   Full year

実地見学

2019.4 - 2020.3   Full year

応用生命化学発展実験

2019.4 - 2020.3   Full year

生物物理化学

2019.4 - 2019.9   First semester

応用生命化学実験

2019.4 - 2019.9   First semester

生物物理化学

2019.4 - 2019.9   First semester

実地見学（応用生命化学分野）

2019.4 - 2019.9   First semester

科学英語（応用生命化学分野）

2019.4 - 2019.9   First semester

基礎生化学

2019.4 - 2019.9   First semester

生物物理化学特論

2019.4 - 2019.9   First semester

生物機能分子化学プロジェクト演習

2019.4 - 2019.9   First semester

生物機能分子化学Ⅱ

2019.4 - 2019.9   First semester

応用生命化学発展実験

2019.4 - 2019.9   First semester

基礎生化学

2019.4 - 2019.9   First semester

生物化学実験

2018.10 - 2019.3   Second semester

生物化学

2018.10 - 2019.3   Second semester

生物化学

2018.10 - 2019.3   Second semester

生物物理化学特論

2018.10 - 2018.12   Fall quarter

構造生物学特論

2018.10 - 2018.12   Fall quarter

生体高分子学特論

2018.4 - 2018.9   First semester

生物物理化学

2018.4 - 2018.9   First semester

基礎生化学

2018.4 - 2018.9   First semester

生物物理化学

2018.4 - 2018.9   First semester

基礎生化学

2018.4 - 2018.9   First semester

生物化学

2017.10 - 2018.3   Second semester

生物化学

2017.10 - 2018.3   Second semester

酵素化学特論

2017.10 - 2018.3   Second semester

生体高分子学特論

2017.10 - 2018.3   Second semester

生物化学実験

2017.10 - 2018.3   Second semester

構造生物学特論

2017.10 - 2017.12   Fall quarter

修士論文

2017.4 - 2018.3   Full year

生物機能分子化学プロジェクト演習

2017.4 - 2018.3   Full year

生物機能分子化学特別研究第一

2017.4 - 2018.3   Full year

生物機能分子化学特別研究第二

2017.4 - 2018.3   Full year

生物物理化学

2017.4 - 2017.9   First semester

生物物理化学

2017.4 - 2017.9   First semester

基礎生化学

2017.4 - 2017.9   First semester

蛋白質化学特論

2017.4 - 2017.9   First semester

生体高分子学特論

2017.4 - 2017.9   First semester

基礎生化学

2017.4 - 2017.9   First semester

生物化学

2016.10 - 2017.3   Second semester

生物化学実験

2016.10 - 2017.3   Second semester

基礎生化学

2016.4 - 2016.9   First semester

生物物理化学

2016.4 - 2016.9   First semester

生体高分子学特論

2016.4 - 2016.9   First semester

応用生物科学概要

2016.4 - 2016.9   First semester

蛋白質化学特論

2016.4 - 2016.9   First semester

Molecular Biology

2016.4 - 2016.9   First semester

生物化学

2015.10 - 2016.3   Second semester

応用生物科学概要

2015.10 - 2016.3   Second semester

生物化学実験

2015.10 - 2016.3   Second semester

基礎生化学

2015.4 - 2015.9   First semester

生体高分子学特論

2015.4 - 2015.9   First semester

応用生物科学概要

2015.4 - 2015.9   First semester

蛋白質化学特論

2015.4 - 2015.9   First semester

Molecular Biology

2015.4 - 2015.9   First semester

生物化学

2014.10 - 2015.3   Second semester

応用生物科学概要

2014.10 - 2015.3   Second semester

生物化学実験

2014.10 - 2015.3   Second semester

基礎化学Ｂ

2014.4 - 2014.9   First semester

生体高分子学特論

2014.4 - 2014.9   First semester

応用生物科学概要

2014.4 - 2014.9   First semester

蛋白質化学特論

2014.4 - 2014.9   First semester

Molecular Biology

2014.4 - 2014.9   First semester

応用生物科学概要

2013.10 - 2014.3   Second semester

生物化学

2013.10 - 2014.3   Second semester

生物化学実験

2013.10 - 2014.3   Second semester

生体高分子学特論

2013.4 - 2013.9   First semester

基礎化学Ｂ

2013.4 - 2013.9   First semester

Molecular Biology

2013.4 - 2013.9   First semester

蛋白質化学特論

2013.4 - 2013.9   First semester

応用生物科学概要

2013.4 - 2013.9   First semester

応用生物科学概要

2012.10 - 2013.3   Second semester

生物化学

2012.10 - 2013.3   Second semester

生物化学実験

2012.10 - 2013.3   Second semester

応用生物科学概要

2012.4 - 2012.9   First semester

基礎化学Ｂ

2012.4 - 2012.9   First semester

生体高分子学特論

2012.4 - 2012.9   First semester

生物化学

2011.10 - 2012.3   Second semester

生物化学実験

2011.10 - 2012.3   Second semester

生体高分子学特論

2011.4 - 2011.9   First semester

基礎化学Ｂ

2011.4 - 2011.9   First semester

生物化学実験

2010.10 - 2011.3   Second semester

生物化学

2010.10 - 2011.3   Second semester

生体高分子学特論

2010.4 - 2010.9   First semester

生物化学実験

2009.10 - 2010.3   Second semester

生物化学

2009.10 - 2010.3   Second semester

コアセミナー

2009.4 - 2009.9   First semester

生物化学実験

2008.10 - 2009.3   Second semester

生物化学

2008.10 - 2009.3   Second semester

生体高分子学特論

2008.4 - 2008.9   First semester

生物化学実験

2007.10 - 2008.3   Second semester

生物化学

2007.10 - 2008.3   Second semester

生体高分子特論

2007.10 - 2008.3   Second semester

生物化学

2006.10 - 2007.3   Second semester

コアセミナー

2006.4 - 2006.9   First semester

蛋白質構造論

2006.4 - 2006.9   First semester

生物化学

2005.10 - 2006.3   Second semester

生物化学

2004.10 - 2005.3   Second semester

生物化学

2003.10 - 2004.3   Second semester

生物化学

2002.10 - 2003.3   Second semester

2003.7   Role：Participation   Title：不明

Organizer：[Undergraduate school/graduate school/graduate faculty]

2002.12   Role：Participation   Title：不明

Organizer：[Undergraduate school/graduate school/graduate faculty]

九州大学「世界に羽ばたく未来創成科学者育成プロジェクト（QFC‐SP）」

2020.8

出張講義

西南学院高等学校  2019.11

九州大学「世界に羽ばたく未来創成科学者育成プロジェクト（QFC‐SP）」

2019.8

九州大学「世界に羽ばたく未来創成科学者育成プロジェクト（FC‐SP）」

2018.8

九州大学「世界に羽ばたく未来創成科学者育成プロジェクト（FC‐SP）」

2017.8

九州大学「世界に羽ばたく未来創成科学者育成プロジェクト（FC‐SP）」

2016.8

夏の学校

高等学校の生物及び化学の教諭対象  2016.6

スーパーサイエンスハイスクール事業における蛋白質結晶学実験

修猷館高校  2006.7

高校生受入プログラム

長崎東高校  2005.7

高校生のための科学講演会

都城市  2003.11

秋の学校（バイオインフォマティクス）

高等学校の生物及び化学の教諭対象  2003.10

2013.3

Staying countory name 1：Philippines   Staying institution name 1：アテネオ・デ・マニラ大学