URUNO TAKEHITO
Organization
Medical Institute of Bioregulation Department of Immunobiology and Neuroscience Associate Professor
Graduate School of Medical Sciences Department of Medicine（Joint Appointment）
Graduate School of Medical Sciences Department of Medical Sciences（Joint Appointment）
Title
Associate Professor
Contact information
Tel
0926426830
Homepage
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https://loop.frontiersin.org/people/479156/overview
Frontiers in Immunology, Guest reviewer
External link
ORCID
Degree
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The University of Tokyo, Ph.D.
Research History
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通産省工業技術院生命工学工業技術研究所（1994~1999）、アメリカ赤十字社ホランド研究所（1999~2004）、アメリカ国立衛生研究所／NIH（2004~2008）、理化学研究所CDB（2008~2009）、九州大学生体防御医学研究所免疫遺伝学分野（特任講師、2009~2013）、九州大学生体防御医学研究所免疫遺伝学分野（助教、2013~2014）、2014年2月〜現職 「細胞生理応答研究から、新しい創薬につながる研究を目指しています」 「次世代の日本の若い研究者に、世界基準の研究価値観を期待しています」
通産省工業技術院生命工学工業技術研究所（1994~1999）、アメリカ赤十字社ホランド研究所（1999~2004）、アメリカ国立衛生研究所／NIH（2004~2008）、理化学研究所CDB（2008~2009）、九州大学生体防御医学研究所免疫遺伝学分野（特任講師、2009~2013）、九州大学生体防御医学研究所免疫遺伝学分野（助教、2013~2014）、2014年2月〜現職 「細胞生理応答研究から、新しい創薬につながる研究を目指しています」 「次世代の日本の若い研究者に、世界基準の研究価値観を期待しています」
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なし
Research Interests・Research Keywords
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Research theme：Immune regulation of diseases and metabolites: Structure-function analysis of the DOCK family proteins and SULTs. Development of novel molecular-targeted drugs for treating cancer, allergy, and immune diseases. Metabolite Biology
Keyword：cancer, immune system, signal transduction, cytoskeleton, drug development
Research period： 2009.5 - 2033.3
Awards
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内藤記念科学奨励金・研究助成
2017.9 公益財団法人 内藤記念科学振興財団
Papers
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Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells Invited Reviewed International journal
Tatsuguchi T, Uruno T, Sugiura Y, Sakata D, Izumi Y, Sakurai T, Hattori Y, Oki E, Kubota N, Nishimoto K, Oyama M, Kunimura K, Ohki T, Bamba T, Tahara H, Sakamoto M, Nakamura M, Suematsu M, Fukui Y.
INTERNATIONAL IMMUNOLOGY 34 ( 5 ) 277 - 289 2022.4
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A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8 Reviewed International journal
4 ( 4 ) e202000873 - e202000873 2021.2
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Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.
Takehito Uruno
Cell reports 2017.5
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The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Takehito Uruno
Nature communications 2017.1
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DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis
Kazufumi Kunimura, Sayaka Akiyoshi, Takehito Uruno, Keisuke Matsubara, Daiji Sakata, Kenji Morino, Kenichiro Hirotani, Yoshinori Fukui
Journal of Allergy and Clinical Immunology 151 ( 6 ) 1585 - 1594.e9 2023.6
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Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. International journal
Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui
Frontiers in immunology 14 1131146 - 1131146 2023.3
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Identification of a functional DOCK8 gene polymorphism associated with atopic dermatitis Reviewed
Kazufumi Kunimura, Kazuhiko Yamamura, Takeshi Nakahara, Makiko Kido-Nakahara, Takehito Uruno, Yoshinori Fukui
Allergy 77 ( 12 ) 3670 - 3672 2022.7
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Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity Reviewed International journal
Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Kounosuke Oisaki, Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura, Testuya Sakurai, Teruki Honma, Takeshi Bamba, Masafumi Nakamura, Motomu Kanai, Makoto Suematsu, Yoshinori Fukui
Biochemical and Biophysical Research Communications 2022.4
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DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells Reviewed International journal
Matsubara K, Kunimura K, Yamane N, Aihara R, Sakurai T, Sakata D, Uruno T, Fukui Y.
Biochem Biophys Res Commun. 559 135 - 140 2021.6
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Targeted inhibition of EPAS1–driven IL-31 production by a small-molecule compound
2021.4
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DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation International journal
Ryosuke Aihara, Kazufumi Kunimura, Mayuki Watanabe, Takehito Uruno, Nana Yamane, Tetsuya Sakurai, Daiji Sakata, Fusanori Nishimura, Yoshinori Fukui
International Immunology 2020.9
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S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches International journal
29 ( 9 ) 2823 - 2834 2019.11
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Selective role of neurokinin B in IL-31-induced itch response in mice.
Takehito Uruno
The Journal of allergy and clinical immunology 144 ( 4 ) 1130 - 1133.e8 2019.8
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Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye International journal
Tetsuya Sakurai, Takehito Uruno, Yuki Sugiura, Takaaki Tatsuguchi, Kazuhiko Yamamura, Miho Ushijima, Yuko Hattori, Mutsuko Kukimoto-Niino, Chiemi Mishima-Tsumagari, Mayuki Watanabe, Makoto Suematsu, Yoshinori Fukui
Science Signaling 11 ( 541 ) 2018.7
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The Rac Activator DOCK2 Mediates Plasma Cell Differentiation and IgG Antibody Production. International journal
Takehito Uruno
Frontiers in immunology 9 243 - 243 2018.2
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DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation.
Takehito Uruno
Biochemical and biophysical research communications 2018.2
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Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Takehito Uruno
Biochemical and biophysical research communications 2017.5
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DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
Takehito Uruno
The Journal of biological chemistry 2016.12
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Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Takehito Uruno
Nature communications 2015.11
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DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation Reviewed International journal
Mayuki Watanabe, Masao Terasawa, Kei Miyano, Toyoshi Yanagihara, Takehito Uruno, Fumiyuki Sanematsu, Akihiko Nishikimi, Jean Francois Cote, Hideki Sumimoto, Yoshinori Fukui
JOURNAL OF IMMUNOLOGY 193 ( 11 ) 2014.12
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DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
Takehito Uruno
Journal of immunology (Baltimore, Md. : 1950) 2014.10
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DOCK5 functions as a key signaling adaptor that links Fc epsilon RI signals to microtubule dynamics during mast cell degranulation Reviewed International journal
Kana Ogawa, Yoshihiko Tanaka, Takehito Uruno, Duan Xuefeng, Yosuke Harada, Fumiki Sanematsu, Kazuhiko Yamamura, Masao Terasawa, Akihiko Nishikimi, Jena Francois Cote, Yoshinori Fukui
JOURNAL OF EXPERIMENTAL MEDICINE 211 ( 7 ) 2014.6
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DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
2014.6
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Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.
Takehito Uruno
PloS one 2012.9
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Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. International journal
Takehito Uruno
Chemistry & biology 19 ( 4 ) 488 - 97 2012.4
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DOCK8は免疫反応時の間質樹状細胞遊走に重要なCdc42アクチベータである
日本免疫学会総会・学術集会記録 41 2012.3
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Racグアニンヌクレオチド交換因子DOCK2及びそのパートナーELMO1のそれらの自己阻害化形からの相互排除のための構造的基盤
109 ( 9 ) 2012.2
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Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1.
Takehito Uruno
The Journal of biological chemistry 2010.7
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Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation. International journal
Takehito Uruno
The Journal of experimental medicine 207 ( 4 ) 721 - 30 2010.3
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Purification of capping protein using the capping protein binding site of CARMIL as an affinity matrix.
Takehito Uruno
Protein expression and purification 2009.5
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CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments.
Takehito Uruno
The Journal of biological chemistry 2006.1
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Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling.
Takehito Uruno
Experimental cell research 2004.8
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Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation.
Takehito Uruno
The Journal of biological chemistry 2003.5
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Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.
Takehito Uruno
The Biochemical journal 2003.4
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Osmotic stress-induced remodeling of the cortical cytoskeleton.
Takehito Uruno
American journal of physiology. Cell physiology 2002.9
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Activation of Arp2/3 complex-mediated actin polymerization by cortactin
URUNO T
Nat. Cell Biol. 3 259 - 266 2001.3
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Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin.
Takehito Uruno
The Biochemical journal 1999.10
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Distinct regulation of myoblast differentiation by intracellular and extracellular fibroblast growth factor-1.
Takehito Uruno
Growth factors (Chur, Switzerland) 1999.1
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The C-terminal region of fibroblast growth factor-1 is crucial for its biological activity and high level protein expression in mammalian cells.
Takehito Uruno
Growth factors (Chur, Switzerland) 1999.1
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Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development.
Takehito Uruno
Brain research. Molecular brain research 1996.9
Presentations
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A tumor metabolite impacting immunotherapy efficacy: Cholesterol sulfate regulates tumor-immune interactions Invited International conference
Takehito Uruo, Takaaki Tatsuguchi, Yuki Sugiura, Yoshinori Fukui
Keystone Symposia on "Cancer Immunotherapy: Mechanisms of Response versus Resistance" 2023.3
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宇留野武人（オーガナイザー）、大石由美子（オーガナイザー） 講演者リスト： 佐藤 隆一郎（東京大学大学院 農学生命科学研究科) Esperanza Perucha（Centre for Inflammation Biology and Cancer Immunology;Centre for Rheumatic Diseases, King’s College London) 高橋 勇人（慶應義塾大学医学部) 大石 由美子（日本医科大学 大学院医学研究科) 小黒 秀行（University of Connecticut Health Center) 國村 和史（九州大学 生体防御医学研究所) 宇留野 武人（九州大学 生体防御医学研究所）
第95回日本生化学大会 2022.11
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ホスファチジン酸産生酵素PLD1は好中球細胞外トラップの形成に必須である
@宇留野 武人、@相原 良亮
第101回日本生理学会大会 2024.3
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がん免疫療法に対する抵抗性を付与する腫瘍メタボライト
@宇留野 武人、#竜口 崇明、@杉浦 悠毅、@福井 宣規
第27回日本がん免疫学会総会 2023.7
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マウスハーダー腺の加齢に伴うトランスクリプトーム・リピドーム変化
宇留野武人、高橋政友
日本生理学会 第100回記念大会 2023.3
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A tumor metabolite impacting immunotherapy efficacy: Cholesterol sulfate regulates tumor-immune interactions Invited
Takehito Uruno, Takaaki Tatsuguchi, Yuki Sugiura, Yoshinori Fukui
Keystone Symposia "Cancer Immunotherapy: Mechanisms of Response versus Resistance" 2023.3
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RAS変異を有する難治性がんの新規分子標的治療薬の開発
宇留野武人、坂田大治、福井宣規、生長幸之助
第94回日本生化学会大会 2021.11
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DOCK1 as a novel molecular target for controlling cancer cell survival and invasion International conference
Tatsuguchi T, Uruno T, Fukui Y
25th Biennial Congress on the European Association for Cancer Research 2018.7
MISC
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DOCK-family proteins: key players in immune surveillance mechanisms
Takehito Uruno
International Immunology 2019.10
Professional Memberships
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The Japanese Biochemical Society
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日本生理学会
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日本がん免疫学会
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日本がん免疫学会
Academic Activities
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Screening of academic papers
Role(s)： Peer review
2023
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事前準備、運営全般 International contribution
（ 九州大学病院キャンパス ） 2014.11
Research Projects
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令和5年度 鈴木謙三記念医科学応用研究財団 研究助成
2024
Grant type：Donation
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基盤研究(B) 腫瘍の免疫特権環境形成における硫酸化コレステロールの役割と創薬応用
2021.4 - 2024.3
九州大学（日本）
Authorship：Principal investigator
腫瘍の免疫特権環境形成における硫酸化コレステロールの役割と創薬応用、機能生物化学関連分野
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AMED革新的がん医療実用化研究事業、「RAS変異を有する難治性がんの新規分子標的治療薬の非臨床評価」
2019.7 - 2022.3
Authorship：Principal investigator
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RAS変異を有する難治性がんの新規分子標的治療薬の非臨床評価
2019 - 2021
AMED 革新的がん医療実用化研究事業
Authorship：Principal investigator Grant type：Contract research
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基盤研究(B) 腫瘍の免疫回避機構におけるRac活性化因子DOCK1の機能
2018.4 - 2021.3
Authorship：Principal investigator
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リジン水酸化酵素Jmjd6を介したAire発現制御の分子基盤とその進化学的考察
2016.4 - 2019.3
Authorship：Coinvestigator(s)
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革新的先端研究開発支援事業インキュベートタイプ（LEAP） DOCKファミリー分子の生体機能と動作原理の理解に基づく革新的医薬品の創出
2015.11 - 2020.3
Authorship：Coinvestigator(s)
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基盤研究(C) ヒト変異型Racによる細胞癌化におけるDOCKファミリー分子の役割
2014.4 - 2017.3
Authorship：Principal investigator
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創薬等支援技術基盤プラットフォーム事業「大型創薬研究基盤を活用した創薬オープンイノベーションの推進（九州大学拠点推進事業）」
2014.4 - 2016.3
Authorship：Coinvestigator(s)
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次世代がん研究戦略推進プロジェクト
2014.4 - 2015.3
Authorship：Coinvestigator(s)
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橋渡し研究・新規開発シーズA
2014.4 - 2015.3
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)
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基盤研究（A) DOCKファミリー分子の生体機能と動作原理の統合的理解
2014.1 - 2016.3
Authorship：Coinvestigator(s)
Class subject
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免疫学
2023.4 - 2023.9 First semester
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医学研究特論 I
2023.4 - 2023.9 First semester
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医学研究特論 I
2021.10 - 2022.3 Second semester
FD Participation
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2019.10 Role：Panelist Title：馬出地区4部局合同男女共同参画ＦＤ
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2017.10 Role：Participation Title：「無意識のバイアスからの開放：ダイバーシティのススメ」
Organizer：University-wide
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2016.10 Role：Participation Title：「なぜ今『女性活躍推進法』か？ —男女共同参画の必要性と九州大学における取組み—」
Organizer：University-wide
Other educational activity and Special note
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2023 Class Teacher
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2021 Special Affairs
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2017 Special Affairs
Media Coverage
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がん抑える新化合物 九大など、副作用少ない薬開発に期待 TV or radio program
2017.5
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九州大・研究グループ がん抑える新たな化合物を開発 Newspaper, magazine
2017.5