Updated on 2024/07/28

Information

 

写真a

 
SAWA SHINICHIRO
 
Organization
Medical Institute of Bioregulation Research Center for Systems Immunology Professor
Medical Institute of Bioregulation Research Center for Systems Immunology（Joint Appointment）
Graduate School of Medical Sciences Department of Medicine（Joint Appointment）
Graduate School of Medical Sciences Department of Medical Sciences（Joint Appointment）
Title
Professor
Contact information
メールアドレス
Tel
0926426962
External link

Degree

  • June 2000, M.D.

  • July 2016, Ph.D (Medical science) Osaka University

Research History

  • 2000年4月-2002年3月　神奈川県立こども医療センター有給研修医（小児内科） 2006年7月-2006年8月　吹田市民病院小児科・非常勤医師

    2000年4月-2002年3月　神奈川県立こども医療センター有給研修医（小児内科） 2006年7月-2006年8月　吹田市民病院小児科・非常勤医師

  • 2006年4月ー2006年6月　大阪大学大学院生命機能研究科・特任研究員 2006年9月ー2011年3月　パスツール研究所（フランス）・博士研究員 2011年4月ー2012年7月　国立成育医療研究センター　生体防御系内科部　・フェロー 2012年8月ー2016年9月　東京大学大学院医学系研究科・助教 2016年10月ー2018年12月　北海道大学遺伝子病制御研究所・准教授 2016年10月ー2018年12月　文部科学省卓越研究員

Research Interests・Research Keywords

  • Research theme：1. To decipher roles of ILC3 in the context of intestinal commensals, epithelium, mesenchymal cell and acquired immunity. 2. To uncover the blueprint for the development of immune organs such as gut-associated lymphoid tissues, lymph node and bone marrow. 3. To elucidate defense against virus in respiratory organ.

    Keyword：mucosal immunology, innate lymphoid cell (ILC), Lymphoid Tissue、Mesenchymal cell, Omics analysis

    Research period： 2019.1 - 2025.12

Awards

  • 日本医師会医学研究奨励賞

    2017.11   日本医師会  

  • 日本免疫学会研究奨励賞

    2011.11   日本免疫学会  

  • 井上研究奨励賞

    2007.2   井上科学振興財団  

Papers

  • Synovial-tissue resident macrophages play proinflammatory functions in the pathogenesis of RA while maintaining the phenotypes in the steady state Reviewed International journal

    #Kai K., @Yamad H., Tsurui R., Sakura K, Fujimura K., Kawahara S., Akasakia Y., Tsushima H., Fujiwara T., Hara D., Fukushi J., @Sawa S., @Nakashima Y

    Immunological Medicine   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.1080/25785826.2023.2300853

  • Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis Reviewed International journal

    Kazuo Oshima, Akinari Hinoki, Hiroo Uchida, Yujiro Tanaka, Yusuke Okuno, Yasuhiro Go, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Aitaro Takimoto, Yoko Kano, @Shinichiro Sawa

    Pediatr Surg Int.   2023.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00383-023-05461-7

  • Dermal Vγ6+ γδ T17 Cells Are Involved in Skin Pressure Ulcers in Mice. Reviewed International journal

    2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1016/j.jid.2021.12.030

  • Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ Macrophage Infiltration. Reviewed International journal

    #Iori Wada, @Shintaro Nakao, @Muneo Yamaguchi, @Yoshihiro Kaizu, @Mitsuru Arima, @Shinichiro Sawa, @Koh-Hei Sonoda

    Investigative ophthalmology & visual science   62 ( 13 )   17   2021.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1167/iovs.62.13.17

  • Fibroblasts as a source of self-antigens for central immune tolerance Reviewed International journal

    Takeshi Nitta, Masanori Tsutsumi Sachiko Nitta, Ryunosuke Muro, Emma C. Suzuki, Kenta Nakano, Yoshihiko Tomofuji, @Shinichiro Sawa, Tadashi Okamura, Josef M. Penninger, Hiroshi Takayanagi

    Nature Immunology   21 ( 10 )   1172 - 1180   2020.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41590-020-0756-8

  • S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches. Reviewed International journal

    #Kunimura K, @Sakata D, #Tun X, @Uruno T, @Ushijima M, Katakai T, @Shiraishi A, Aihara R, Kamikaseda Y, Matsubara K, Kanegane H, @Sawa S, Eberl G, @Ohga S, Yoshikai Y, @Fukui Y.

    Cell Rep   29 ( 9 )   2823 - 2834   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.celrep.2019.10.091

  • Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver Reviewed

    Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Alejandro Prados, Vasiliki Koliaraki, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi

    Biochemical and Biophysical Research Communications   493 ( 1 )   437 - 443   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2017.09.004

  • Osteoimmunology The conceptual framework unifying the immune and skeletal systems Reviewed

    Kazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta, Hiroshi Takayanagi

    Physiological Reviews   97 ( 4 )   1295 - 1349   2017.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/physrev.00036.2016

  • Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis Reviewed

    Immunity   47 ( 1 )   80 - 92.e4   2017.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.immuni.2017.05.008

  • Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota Reviewed

    Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Masanori Tsutsumi, Tadashi Okamura, Josef M. Penninger, Tomoki Nakashima, Hiroshi Takayanagi

    Nature Immunology   18 ( 6 )   675 - 682   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ni.3732

  • SLAM-associated protein favors the development of iNKT2 over iNKT17 cells Reviewed

    European Journal of Immunology   46 ( 9 )   2162 - 2174   2016.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/eji.201646313

  • RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation Reviewed

    Lynett Danks, Noriko Komatsu, Matteo M. Guerrini, Shinichiro Sawa, Marietta Armaka, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi

    Annals of the Rheumatic Diseases   75 ( 6 )   1187 - 1195   2016.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/annrheumdis-2014-207137

  • Immune complexes regulate bone metabolism through FcRγ signalling Reviewed

    Takako Negishi-Koga, Hans Jürgen Gober, Eriko Sumiya, Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Ayako Suematsu, Tomomi Suda, Kojiro Sato, Toshiyuki Takai, Hiroshi Takayanagi

    6   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Autoantibody production and immune complex (IC) formation are frequently observed in autoimmune diseases associated with bone loss. However, it has been poorly understood whether ICs regulate bone metabolism directly. Here we show that the level of osteoclastogenesis is determined by the strength of FcRγ signalling, which is dependent on the relative expression of positive and negative FcγRs (FcγRI/III/IV and IIB, respectively) as well as the availability of their ligands, ICs. Under physiological conditions, unexpectedly, FcγRIII inhibits osteoclastogenesis by depriving other osteoclastogenic Ig-like receptors of FcRγ. Fcgr2b-/-mice lose bone upon the onset of a hypergammaglobulinemia or the administration of IgG1 ICs, which act mainly through FcγRIII. The IgG2 IC activates osteoclastogenesis by binding to FcγRI and FcγRIV, which is induced under inflammatory conditions. These results demonstrate a link between the adaptive immunity and bone, suggesting a regulatory role for ICs in bone resorption in general, and not only in inflammatory diseases.

    DOI： 10.1038/ncomms7637

  • Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System Reviewed

    Matteo M. Guerrini, Kazuo Okamoto, Noriko Komatsu, Shinichiro Sawa, Lynett Danks, Josef M. Penninger, Tomoki Nakashima, Hiroshi Takayanagi

    Immunity   43 ( 6 )   1174 - 1185   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.immuni.2015.10.017

  • Pathogenic conversion of Foxp3 + T cells into TH17 cells in autoimmune arthritis Reviewed

    Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa, Tomoki Nakashima, Masatsugu Ohora, Tatsuhiko Kodama, Sakae Tanaka, Jeffrey A. Bluestone, Hiroshi Takayanagi

    Nature medicine   20 ( 1 )   62 - 68   2014.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/nm.3432

  • Roles of RORγt+ innate lymphoid cells in mucosal tissues of mouse and human Reviewed

    36 ( 1 )   11 - 16   2013.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Innate Lymphoid cells (ILCs) are recently defined lymphocytes composed of several subsets such as Natural Killer (NK), Natural Helper (NH) and RORγt+ cells, which have no antigen receptors but exhibit rapid cytokine production after stimulation. Murine RORγt+ ILCs can be classified either as CCR6+c-kithighIL-7Rahigh or CCR6-NKp46+ cells. The former ones play roles on the formation of secondary lymphoid tissues and the later ones contribute to the maintenance of intestinal epithelial integrity by producing IL-22. Human fetal intestine, tonsil and lympho nodes harbor both NKp44 positive and negative RORγt+ ILC subsets. Since human Crohn's disease patients have increased number of RORγt+ ILCs in the in‰amed intestine, roles of RORγt+ ILCs on the pathogenesis of Crohn's disease became of great interest.

    DOI： 10.2177/jsci.36.11

  • Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells Reviewed

    Marie Cherrier, Shinichiro Sawa, Gérard Eberl

    209 ( 4 )   729 - 740   2012.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    AbstracyLymphoid tissue development is initiated during embryogenesis by the migration of lymphoid tissue inducer (LTi) cells from the fetal liver to the periphery, where they induce the formation of lymph nodes and Peyer's patches. In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin α4β7 gives rise to LTi cells, a process strictly dependent on the expression of the transcriptional repressor Id2 and the nuclear hormone receptor retinoic acid-related orphan receptor γ t (RORγt). In this study, we show that Id2 and RORγt are sequentially up-regulated during LTi cell development, matching two waves of differentiation with opposite requirements for Notch signaling. Both the expression of Id2 and Notch are required for the generation of α4β7 + RORγt - fetal progenitors, but Notch subsequently blocks progression to the RORγt + stage and final maturation of LTi cells. Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate.

    DOI： 10.1084/jem.20111594

  • Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity Reviewed

    Cellular Microbiology   13 ( 5 )   653 - 659   2011.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1462-5822.2011.01577.x

  • RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota Reviewed

    Shinichiro Sawa, Matthias Lochner, Naoko Satoh-Takayama, Sophie Dulauroy, Marion Bérard, Melanie Kleinschek, Daniel Cua, James P. Di Santo, Gérard Eberl

    12 ( 4 )   320 - 328   2011.4

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    Lymphoid cells that express the nuclear hormone receptor RORβ 3t are involved in containment of the large intestinal microbiota and defense against pathogens through the production of interleukin 17 (IL-17) and IL-22. They include adaptive IL-17-producing helper T cells (TH 17 cells), as well as innate lymphoid cells (ILCs) such as lymphoid tissueĝ€" inducer (LTi) cells and IL-22-producing NKp46+ cells. Here we show that in contrast to TH 17 cells, both types of RORγ t + ILCs constitutively produced most of the intestinal IL-22 and that the symbiotic microbiota repressed this function through epithelial expression of IL-25. This function was greater in the absence of adaptive immunity and was fully restored and required after epithelial damage, which demonstrates a central role for RORγ t+ ILCs in intestinal homeostasis. Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and RORγ t+ ILCs.

    DOI： 10.1038/ni.2002

  • Lymphotoxin-β receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells Reviewed

    Naoko Satoh-Takayama, Sarah Lesjean-Pottier, Shinichiro Sawa, Christian A.J. Vosshenrich, Gérard Eberl, James P. Di Santo

    41 ( 3 )   780 - 786   2011.3

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    The natural cytotoxicity receptor NKp46 is an activating receptor expressed by several distinct innate lymphoid cell (ILC) subsets, including NK cells, some γδ T cells and intestinal RORγt+IL-22+ cells (NCR22 cells, IL-22-producing NKp46+ cell). NCR22 cells may play a role in mucosal barrier function through IL-22-mediated production of anti-bacterial peptides from intestinal epithelial cells. Previous studies identified a predominant proportion of NCR22 cells in gut cryptopatches (CP), lymphoid structures that are strategically positioned to collect and integrate signals from luminal microbes; however, whether CP or other lymphoid structures condition NCR22 cell differentiation is not known. Programmed and inducible lymphoid tissue development requires cell-surface-expressed lymphotoxin (LT)α1β2 heterotrimers (provided by lymphoid tissue inducer (LTi) cells) to signal lymphotoxin-β receptor (LTR)+ stromal cells. Here, we analyzed NCR22 cells in LTβR-deficient Ncr1GFP/+ mice that lack organized secondary lymphoid tissues. We found that NCR22 cells develop in the absence of LTβR, become functionally competent and localize to the lamina propria under steady-state conditions. Following infection of LTβR-/- mice with the Gram-negative pathogen Citrobacter rodentium, IL-22 production from NCR22 cells was not affected. These results indicate that organized lymphoid tissue structures are not critical for the generation of an intact and fully functional intestinal NCR22 cell compartment.

    DOI： 10.1002/eji.201040851

  • Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells Reviewed

    Journal of Immunology   186 ( 3 )   1531 - 1537   2011.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.1001723

  • Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells Reviewed

    Matthias Lochner, Caspar Ohnmacht, Laura Presley, Pierre Bruhns, Mustapha Si-Tahar, Shinichiro Sawa, Gérard Eberl

    208 ( 1 )   125 - 134   2011.1

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    The programmed development of lymph nodes and Peyer's patches during ontogeny requires lymphoid tissue inducer (LTi) cells that express the nuclear hormone receptor RORγt. After birth, LTi cells in the intestine cluster into cryptopatches, the precursors of isolated lymphoid follicles (ILFs), which are induced to form by symbiotic bacteria and maintain intestinal homeostasis. We show that in RORγt-deficient mice, which lack LTi cells, programmed lymphoid tissues, ILFs, and Th17 cells, bacterial containment requires the generation of large numbers of tertiary lymphoid tissues (tLTs) through the activity of B cells. However, upon epithelial damage, these mice develop severe intestinal inflammation characterized by extensive recruitment of neutrophils and IgG+ B cells, high expression of activation-induced deaminase in tLTs, and wasting disease. The pathology was prevented by antibiotic treatment or inhibition of lymphoid tissue formation and was significantly decreased by treatment with intravenous immunoglobulin G (IVIG). Our data show that intestinal immunodeficiency, such as an absence in RORγt-mediated proinflammatory immunity, can be compensated by increased lymphoid tissue genesis. However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology.

    DOI： 10.1084/jem.20100052

  • Lineage relationship analysis of RORγt+ innate lymphoid cells Reviewed

    Shinichiro Sawa, Marie Cherrier, Matthias Lochner, Naoko Satoh-Takayama, Hans Jörg Fehling, Francina Langa, James P. Di Santo, Gérard Eberl

    330 ( 6004 )   665 - 669   2010.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    Lymphoid tissue - inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt+ innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt+ precursors. The fate of RORγt+ ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt+ T cells, however, RORγt + ILCs develop in the absence of microbiota. Our study indicates that RORγt+ ILCs evolve to preempt intestinal colonization by microbial symbionts.

    DOI： 10.1126/science.1194597

  • IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors Reviewed

    Naoko Satoh-Takayama, Sarah Lesjean-Pottier, Paulo Vieira, Shinichiro Sawa, Gerard Eberl, Christian A.J. Vosshenrich, James P. Di Santo

    Journal of Experimental Medicine   207 ( 2 )   273 - 280   2010.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1084/jem.20092029

  • Opening the crypt current facts and hypotheses on the function of cryptopatches Reviewed

    Trends in Immunology   31 ( 2 )   50 - 55   2010.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.it.2009.11.004

  • Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense Reviewed

    Naoko Satoh-Takayama, Christian A.J. Vosshenrich, Sarah Lesjean-Pottier, Shinichiro Sawa, Matthias Lochner, Frederique Rattis, Jean Jacques Mention, Kader Thiam, Nadine Cerf-Bensussan, Ofer Mandelboim, Gerard Eberl, James P. Di Santo

    Immunity   29 ( 6 )   958 - 970   2008.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.immuni.2008.11.001

  • In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells Reviewed

    Matthias Lochner, Lucie Peduto, Marie Cherrier, Shinichiro Sawa, Francina Langa, Rosa Varona, Dieter Riethmacher, Mustapha Si-Tahar, James P. Di Santo, Gérard Eberl

    205 ( 6 )   1381 - 1393   2008.6

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    The nuclear hormone receptor retinoic acid receptor-related orphan receptor γt (RORγt) is required for the generation of T helper 17 cells expressing the proinflammatory cytokine interleukin (IL)-17. In vivo, however, less than half of RORγt+ T cells express IL-17. We report here that RORγt+ Tαβ cells include Foxp3+ cells that coexist with IL-17-producing RORγt+ Tαβ cells in all tissues examined. The Foxp3+ RORγt+ Tαβ express IL-10 and CCL20, and function as regulatory T cells. Furthermore, the ratio of Foxp3+ to IL-17-producing RORγt + Tαβ cells remains remarkably constant in mice enduring infection and inflammation. This equilibrium is tuned in favor of IL-10 production by Foxp3 and CCL20, and in favor of IL-17 production by IL-6 and IL-23. In the lung and skin, the largest population of RORγt+ T cells express the γδ T cell receptor and produce the highest levels of IL-17 independently of IL-6. Thus, potentially antagonistic proinflammatory IL-17-producing and regulatory Foxp3+ RORγt+ T cells coexist and are tightly controlled, suggesting that a perturbed equilibrium in RORγt+ T cells might lead to decreased immunoreactivity or, in contrast, to pathological inflammation.

    DOI： 10.1084/jem.20080034

  • Homeostatically proliferating CD4+ T cells are involved in the pathogenesis of an Omenn syndrome murine model Reviewed

    Khie Khiong, Masaaki Murakami, Chika Kitabayashi, Naoko Ueda, Shinichiro Sawa, Akemi Sakamoto, Brian L. Kotzin, Stephen J. Rozzo, Katsuhiko Ishihara, Marileila Verella-Garcia, John Kappler, Philippa Marrack, Toshio Hirano

    Journal of Clinical Investigation   117 ( 5 )   1270 - 1281   2007.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1172/JCI30513

  • CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4 Reviewed

    Naoko Ueda, Hiroko Kuki, Daisuke Kamimura, Shinichiro Sawa, Kenichiro Seino, Takuya Tashiro, Ken Ichi Fushuku, Masaru Taniguchi, Toshio Hirano, Masaaki Murakami

    International Immunology   18 ( 9 )   1397 - 1404   2006.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/intimm/dxl073

  • Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4 + T cells Reviewed

    Shinichiro Sawa, Daisuke Kamimura, Gui Hua Jin, Hideyuki Morikawa, Hokuto Kamon, Mika Nishihara, Katsuhiko Ishihara, Masaaki Murakami, Toshio Hirano

    Journal of Experimental Medicine   203 ( 6 )   1459 - 1470   2006.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1084/jem.20052187

  • IL-6-STAT3 controls intracellular MHC class II αβ dimer level through cathepsin S activity in Dendritic Cells Reviewed

    23 ( 5 )   491 - 502   2005.11

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    We found IL-6-STAT3 pathway suppresses MHC class II (MHCII) expression on dendritic cells (DCs) and attenuates T cell activation. Here, we showed that IL-6-STAT3 signaling reduced intracellular MHCII αβ dimmer, Ii, and H2-DM levels in DCs. IL-6-mediated STAT3 activation decreased cystatin C level, an endogenous inhibitor of cathepsins, and enhanced cathepsin activities. Importantly, cathepsin S inhibitors blocked reduction of MHCII αβ dimer, Ii, and H2-DM in the IL-6-treated DCs. Overexpression of cystatin C suppressed IL-6-STAT3-mediated increase of cathepsin S activity and reduction of MHCII αβ dimer, Ii, and H2-DM levels in DCs. Cathepsin S overexpression in DCs decreased intracellular MHCII αβ dimer, Ii, and H2-DM levels, LPS-mediated surface expression of MHCII and suppressed CD4 + T cell activation. IL-6-gp130-STAT3 signaling in vivo decreased cystatin C expression and MHCII αβ dimer level in DCs. Thus, IL-6-STAT3-mediated increase of cathepsin S activity reduces the MHCII αβ dimer, Ii, and H2-DM levels in DCs, and suppresses CD4+ T cell-mediated immune responses.

    DOI： 10.1016/j.immuni.2005.09.010

  • Hyperactivation of gp130-mediated STAT3 signaling induces a rheumatoid arthritis-like disease that is dependent on MHC class II restricted CD4+ T cells Reviewed

    Masaaki Murakami, Shinichiro Sawa, Daisuke Kamimura, Hokuto Kamon, Hidemitsu Kitamura, Takaya Kawabe, Park Sung-Joo, Katsuhiko Ishihara, Toshio Hirano

    International Congress Series   1285   207 - 211   2005.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ics.2005.07.096

  • Evidence of a novel IL-2/15Rβ-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells Reviewed

    173 ( 10 )   6041 - 6049   2004.11

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    The homeostasis of memory CD8+ T cells is regulated by cytokines. IL-15 is shown to promote the proliferation of Memory CD8+ T cells, while IL-2 suppresses their division in vivo. This inhibitory efect of IL-2 appears to occur indirectly, through other cell populations including CD25+CD4+ T cells; however, the details of this mechanism remain unclear. In this study, we show that 1) both Ag-experienced and memory phenotype CD8+ T cells divided after the depletion of IL-2 in vivo; 2) this division occurred normally and CD44highIL-2/ 15Rβhigh CD8+ T cells generated after IL-2 depletion in IL-15 knockout (KO) and in IL-7-depleted IL-15 KO mice; 3) surprisingly, the blockade of IL-2/15Rβ signaling in IL-2-depleted IL-15 KO mice completely abolished the division of memory CD8+ T cells, although the only cytokines known to act through IL-2/15Rβ are IL-2 and IL-15; and 4) the expression of IL-2/15Rβ molecules on memory CD8+ T cells was required for their division induced by IL-2 depletion. These results demonstrate that the depletion of IL-2 in vivo induced memory CD8+ T cell division by an IL-15-independent but by an IL-2/15Rβ-dependent mechanism, suggesting the existence of a novel IL-2/15Rβ-utilizing cytokine that acts directly on memory CD8+ T cells to promote cell division.

  • IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation Reviewed

    Sung Joo Park, Takayuki Nakagawa, Hidemitsu Kitamura, Toru Atsumi, Hokuto Kamon, Shinichiro Sawa, Daisuke Kamimura, Naoko Ueda, Yoichiro Iwakura, Katsuhiko Ishihara, Masaaki Murakami, Toshio Hirano

    Journal of Immunology   173 ( 6 )   3844 - 3854   2004.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.173.6.3844

  • The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis Reviewed

    Katsuhiko Ishihara, Shinichiro Sawa, Hideto Ikushima, Seiichi Hirota, Toru Atsumi, Daisuke Kamimura, Sung Joo Park, Masaaki Murakami, Yukihiko Kitamura, Yoichiro Iwakura, Toshio Hirano

    International Immunology   16 ( 3 )   455 - 465   2004.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/intimm/dxh045

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Presentations

  • リンパ節ストローマ細胞における細胞系譜関係の解析

    @澤新一郎、@住谷瑛理子

    2019.6 

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    Event date： 2019.6

    Language：Japanese  

    Venue：京都大学芝蘭会館（京都市）   Country：Japan  

    【背景・目的】
    ストローマ細胞は成熟リンパ節の機能的分画化と構造維持に重要な間葉系細胞であるが、その起源や分化過程は詳細に検討されていない。昨年の本学会において、リンパ節原基中のRANKL陽性細胞がリンパ節初期発生に必須の間葉系細胞（Lymphoid Tissue organizer=LTo細胞）としてLTbRシグナルを伝達することを報告した。今回我々は、RANKL発現細胞とリンパ節ストローマ細胞の細胞系譜関係の解明を目的とした。
    【方法・結果】
    まず、Brainbawシステムを用い、リンパ節ストローマ細胞が複数のRANKL発現細胞に由来することを明らかにした。次に、Tnfsf11tTA/+ マウスを新規作成し、ドキシサイクリンを用いたRANKL 陽性細胞の時期特異的な標識・追跡系を樹立した。鼠径部リンパ節では、T細胞領域を構成するFRCが胎齢16日目以降のRANKL陽性細胞に由来すること、リンパ節辺縁部に存在するMRCは出生後にRANKLを発現した間葉系細胞に由来することを明らかにした。一方、胎齢15日目でリンパ節原基に生着したRANKL陽性間葉系を標識しても殆どのリンパ節ストローマ細胞は標識されなかった。
    【結論・考察】
    リンパ節ストローマ細胞の多くは胎仔期に存在するRANKL発現細胞に由来するが、幹細胞のように単一のLTo細胞が自己複製と成熟過程を経て全リンパ節ストローマ細胞へと分化する可能性は極めて低い。リンパ節分画をstep-by-stepに構築し、リンパ球を効率的に集簇させるためには、複数の間葉系細胞においてRANKL発現が連鎖的に誘導されるモデルがより適切と考えられる。

  • Cytoplasmic signaling molecule CySM2 in LTi cells plays critical role on Payer’s patch formation International conference

    #Naoko Kiya, @Miho Matsuda　and @Shinichiro Sawa

    KOB (Kyudai Oral Biosciences)・OBT・DDR 合同国際シンポジウム  2024.2 

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    Event date： 2024.2

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン   Country：Japan  

  • Investigation of RUNX/CBFβ role for ILC3 and GALT formation International conference

    第52回日本免疫学会学術集会  2024.1 

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    Language：Japanese  

    Venue：幕張メッセ（千葉）   Country：Japan  

  • Identification of CSF1-producing cells required for the maintenance of intestinal macrophages International conference

    #Daichi Nonaka, #Soichiro Yoshida, Eriko Sumiya, @Shinichiro Sawa

    2024.1 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Regulatory mechanism of RORgt expression in innate and adaptive lymphocytes Invited International conference

    @Shinichiro Sawa

    2024.1 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • RANKL-expressing cells in the primary ossification center functions as an osteoclast niche during early bone marrow development International conference

    Eriko Sumiya, @Shinichiro Sawa

    2024.1 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • リンパ球におけるRORgt発現制御機構 Invited

    @澤　新一郎

    静岡県立大学　第312回月例薬学セミナー  2023.12 

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    Event date： 2023.12

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：静岡県立大学   Country：Japan  

  • Regulatory mechanism of RORgt expression in innate and adaptive lymphocytes International conference

    @Shinichiro Sawa

    The 32nd Hot Spring Harbor International Symposium  2023.10 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 腸管免疫における自然リンパ球の役割 Invited

    @澤 新一郎

    第35回日本神経免疫学会学術講演会  2023.9 

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    Event date： 2023.9

    Language：Japanese  

    Venue：東京国際フォーラム（東京）   Country：Japan  

  • 免疫組織の設計図を解読する Invited

    @澤　新一郎

    第２回シングルセルゲノミクス研究会  2022.8 

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    Event date： 2023.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都みやこめっせ   Country：Japan  

  • Identification of CSF1-producing cells required for the maintenance of intestinal macrophages

    #Daichi Nonaka, Eriko Sumiya, @Shinichiro Sawa

    2024.8 

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    Event date： 2023.8

    Language：Japanese  

    Country：Japan  

  • 免疫応答の場を作る細胞たち Invited

    ＠澤 新一郎

    第24回免疫サマースクール2023 in 福岡  2023.8 

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    Event date： 2023.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡アイランドシティフォーラム （福岡）   Country：Japan  

  • Investigation of Runx/CBfb-dependent GALT formation

    #Reo Kobayashi, @Miyuki Watanabe, Eriko Sumiya, @Shinichiro Sawa

    2024.5 

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    Event date： 2023.8

    Language：Japanese  

    Country：Japan  

  • ILC3におけるRORgt発現制御機構の解明

    #福井 卓磨，香城 諭，@渡邊　美幸， 住谷　瑛里子,@澤　新一郎

    第43回阿蘇シンポジウム  2023.7 

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    Event date： 2023.7

    Language：Japanese  

    Venue：熊本城ホール（熊本）   Country：Japan  

  • 胎仔期の軟骨-骨境界面に局在するセプトクラストは破骨細胞形成を促進し骨髄腔の発生に寄与する

    住谷 瑛理子，@澤 新一郎

    第41回日本骨代謝学会学術集会  2023.7 

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    Event date： 2023.7

    Language：Japanese  

    Venue：都市センターホテル （東京）   Country：Japan  

  • 胸腺成熟過程におけるLymphotoxin発現細胞の探索

    @渡邊　美幸, @澤　新一郎

    第32回 Kyoto T Cell Conference (KTCC)  2023.6 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都大学芝蘭会館（京都）   Country：Japan  

  • インフルエンザウイルス感染により肺組織に出現するケモカイン高産生性線維芽細胞の役割を問う

    @澤新一郎, @小泉真一, @山田大翔, 野口直人, 住谷瑛理子

    JST-MS ムーンショット目標2×7技術交流会  2023.6 

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    Event date： 2023.6

    Language：Japanese  

    Venue：御茶ノ水ソラシティカンファレンスセンター　（東京）   Country：Japan  

  • リンパ球におけるRORt発現制御機構 Invited

    @澤　新一郎

    第21回　四国免疫フォーラム  2023.6 

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    Event date： 2023.6

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：徳島大学　大塚記念講堂   Country：Japan  

  • Transcriptional regulation of RORγt in innate and adaptive lymphocytes

    ＠澤新一郎

    第21回四国免疫フォーラム  2023.6 

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    Language：Japanese  

    Venue：徳島大学　大塚記念講堂   Country：Japan  

  • Identification of CSF1-producing cells required for the maintenance of intestinal macrophages International conference

    #Daichi Nonaka, Eriko Sumiya, @Shinichiro Sawa

    The 29th International Symposium on Molecular and Cell Biology of Macrophage  2023.5 

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    Event date： 2023.5 - 2024.5

    Language：English  

    Country：Japan  

  • 自己体内に存在する細菌の役割とその活用 Invited

    @澤　新一郎

    第110回日本泌尿器科学会  2023.4 

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    Event date： 2023.4

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：神戸国際会議場（神戸）   Country：Japan  

  • 腸管マクロファージニッチ細胞の検討

    @澤　新一郎

    第7回理論免疫学ワークショップ  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：鹿児島ライカ   Country：Japan  

  • 免疫組織の形成を担う自己免疫疾患関連分子 Invited

    ＠澤新一郎

    第14回大阪骨関節コロキウム  2022.12 

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    Event date： 2022.12

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：大阪大学   Country：Japan  

  • Cartilage-degrading cells in the primary ossification center contributes to perinatal bone marrow development International conference

    2022.12 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • CSF1-producing cells in the intestine contributes to the maintenance of macrophages

    #Daichi Nonaka @Eriko sumiya @Shinichiro Sawa

    2022.12 

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    Event date： 2022.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Regulatory mechanism of RORgt expression in ILC3

    #Takuma Fukui Satoshi Kojo @Eriko Sumiya @Shinichi Koizumi @Shinichiro Sawa

    2023.6 

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    Event date： 2022.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Analysis of fibroblasts that initiate iBALT formation during influenza virus infection International conference

    2022.12 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Prip2 is required for the formation of gut-associated lymphoid tissue International conference

    2022.12 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Regulatory mechanism of RORgt expression in ILC3

    #Takuma Fukui @Satoshi Kojo Eriko Sumiya @Miyuki Watanabe @Shinichiro Sawa

    The 31st Hot Spring Harbor International Symposium  2022.11 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Transcriptomic landscapes of whole lung cells after influenza virus infection in mouse Invited International conference

    @Shinichiro Sawa

    The 20th Awaji International Forum on Infection and Immunity  2022.9 

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    Event date： 2022.9

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 骨と骨髄の発生に寄与する新規間葉系細胞集団の同定

    ＠住谷　瑛理子 佐伯亘平 ＠澤　新一郎

    第２回シングルセルゲノミクス研究会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都みやこめっせ   Country：Japan  

  • ILC3研究のこれまで、これから Invited

    ＠澤　新一郎

    日本免疫学会サマースクール  2022.8 

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    Event date： 2022.8 - 2023.8

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：大阪大学会館   Country：Japan  

  • 粘膜免疫研究の最前線 Invited

    @ 澤新一郎

    第42回阿蘇シンポジウム  2022.7 

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    Event date： 2022.7 - 2023.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：熊本城ホール/オンライン   Country：Japan  

  • 一次骨化中心に出現する胎仔RANKL陽性細胞は骨芽細胞および骨髄ストローマ細胞へ分化することで骨の発生に寄与する

    ＠住谷　瑛理子 ＠澤　新一郎

    第40回日本骨代謝学会学術集会  2022.7 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：長良川国際会議場・都ホテル 岐阜長良川   Country：Japan  

  • RANKL-expressing fetal perichondrial cells promote bone and bone marrow development

    2022.7 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • ILC3/LTi細胞におけるRORgt発現制御機構の解明

    ＃福井　卓磨 香城　諭 ＠住谷　瑛理子 ＠小泉　真一 ＠澤　新一郎

    第31回　Kyoto T cell Conference  2022.5 

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    Event date： 2022.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン   Country：Japan  

  • 腸管マクロファージの維持に寄与するCSF1産生細胞の解析

    #野中　大地 @住谷　瑛理子 @澤　新一郎

    第31回　Kyoto T cell Conference  2022.5 

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    Event date： 2022.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン   Country：Japan  

  • 病原性微生物感染動物からの細胞単離とシングルセルRNAシークエンスの実際 Invited

    ＠澤　新一郎

    ナノスティングス学会  2022.2 

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    Event date： 2022.2

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：on line   Country：Japan  

  • Epigenomic and genetic approaches to identify Rorc enhancers indispensable for LTi cell development International conference

    2022.1 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Transcriptomic landscape of whole lung cells after influenza virus infection in mouse International conference

    @Shinichi Koizumi Naoto Noguchi @Eriko Sumiya @Shinichiro Sawa

    2022.1 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • RANKL+ cells in the primary ossification center contributes to perinatal bone marrow development

    2021.12 

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    Event date： 2021.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • LTi-like cell conducts maturation of intestinal immune system Invited International conference

    @Shinichiro Sawa

    2020.12 

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    Event date： 2020.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • ILC3の発見から最新の研究まで Invited

    @澤新一郎

    2020.11 

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    Event date： 2020.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：ホテルオークラ　福岡   Country：Japan  

  • 胎仔破骨細胞誘導細胞の生体内における分化能の解析

    @住谷瑛理子, @澤新一郎

    第37回日本骨代謝学会学術集会  2020.10 

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    Event date： 2020.10

    Language：Japanese  

    Venue：神戸国際会議場   Country：Japan  

  • Which cells initiate lymph node formation? Invited International conference

    2020.9 

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    Event date： 2020.9

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 胎児期における免疫組織形成機構の解明 Elucidation for developmental mechanism of immune organs during fetal stage Invited

    @澤　新一郎

    第31回日本生体防御学会学術集会  2020.9 

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    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：熊本城ホール内シビックホール／Web   Country：Japan  

    造血幹細胞から分化発生するリンパ球や骨髄球などの免疫細胞は生体防御を担う中核的な存在である。我々は、免疫細胞が維持され免疫応答の場として機能するリンパ節や造血の場として重要な骨髄が個体発生の過程でどのように構築されるか、という観点から研究を進めてきた。
    　胎児期におけるリンパ節形成は自然リンパ球系の細胞であるLymphoid Tissue inducer (LTi) 細胞と間葉系細胞の相互活性化が最初の引き金になると考えられてきた。LTi細胞が発現するLymphotoxin (LT)12はリンパ節形成に必須のサイトカインであるが、その受容体LTbRの発現には特異性がなく、何が「リンパ節を形成する場所」を決めているか不明であった。我々はLTi細胞におけるLT12発現を増強させる特殊な間葉系細胞をリンパ節原基に同定した。この間葉系細胞特異的にLTbR発現を欠損させるとリンパ節の形成は完全に阻害されたことから、この細胞こそがリンパ節形成に必須の間葉系細胞であると結論付けた。
    　骨髄がどのようなメカニズムで硬い骨の中に構築され、造血を担うようになるかほとんど明らかになっていない。我々はマクロファージ系の細胞である破骨細胞を欠損するマウスで骨髄腔が形成されないことに注目し、破骨細胞が骨髄空間の形成に果たす役割について検討した。詳細な検討の結果、胎生15日に骨中央部に形成される軟骨膜付近に破骨細胞の誘導に必須の間葉系細胞が出現することを突き止めた。これらの間葉系細胞は自身が骨基質を形成するとともに骨髄ストローマ細胞へ分化する。破骨細胞が存在しない条件下では骨髄内での骨化が進み、造血に有効な骨髄空間が得られず、出生後の造血障害を引き起こすことが明らかになった。
    　出生直後における外来微生物との遭遇を予見し、胎児期からリンパ節や骨髄を予め構築しておくことは生体防御の観点から大変理に適ったシステムであると考えられる。

  • If ILC3s are absent, what happens in the gut?, Shinichiro Sawa, JSPS-Crick Symposium on Gut Circuits Invited International conference

    @Shinichiro Sawa

    JSPS-Crick Symposium on Gut Circuits  2020.6 

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    Event date： 2020.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United Kingdom  

  • Transcriptomic characterization of cells involved in fetal bone development International conference

    @Eriko Sumiya, @Shinichiro Sawa

    The 29th Hot Spring Harbor International Symposium  2020.2 

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    Event date： 2020.2

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 「免疫の場」を構成する細胞群の運命追跡 Invited

    @澤新一郎

    第4回理論免疫学ワークショップ  2020.1 

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    Event date： 2020.1

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Country：Japan  

  • RANKL+ mesenchymal cell is the genuine lymphoid tissue organizer cell in the developing lymph node International conference

    @Shinichiro Sawa

    2019.10 

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    Event date： 2019.10

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • リンパ節ストローマ細胞の起源に迫る Invited

    @澤　新一郎

    第 8 回生命科学阿波おどりシンポジウム  2019.8 

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    Event date： 2019.8

    Language：English   Presentation type：Oral presentation (general)  

    Venue：徳島大学　先端酵素学研究所   Country：Japan  

  • If ILC3s are absent, what happens in the gut? Invited International conference

    @Shinichiro Sawa

    JSPS-Crick Symposium on Gut Circuits  2019.6 

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    Event date： 2019.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United Kingdom  

    Other Link： https://www.eventbrite.co.uk/e/jsps-crick-symposium-on-gut-circuits-tickets-58644719936#

  • Investigation for the cell lineage of lymph node stroma cell

    2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 骨と骨髄の発生におけるRANKL陽性未分化間葉系細胞の寄与の解明

    @住谷瑛理子、@澤新一郎

    2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都大学芝蘭会館（京都市）   Country：Japan  

  • 骨と骨髄の発生におけるRANKL陽性未分化間葉系細胞の寄与の解明

    @住谷瑛理子, @澤新一郎

    第29回 Kyoto T Cell Conference  2019.5 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都大学芝蘭会館（京都市）   Country：Japan  

  • The role of fetal osteoclast inducer cells in perinatal bone marrow development

    @Eriko Sumiya, @Shinichiro Sawa

    2018.12 

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    Event date： 2018.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Fundamental role of LTi-like cell in the maintenance of adult intestinal homeostasis

    @Shinichiro Sawa,Kenta Nakano,Tadashi Okamura, @Eriko Sumiya

    2018.12 

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    Event date： 2018.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • RANKL+ mesenchymal cellis the genuine lymphoid tissue organizer cell in the developing lymph-node International conference

    @Sawa S., @Sumiya E., Nakano K., Okamura T.

    3rd International Conference on Innate Lymphoid Cells (ILC2018)  2018.11 

    　More details

    Event date： 2018.11 - 2018.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 自然リンパ球と疾患 Invited

    @澤　新一郎

    第1回北海道移植免疫研究会  2018.9 

    　More details

    Event date： 2018.9

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：札幌市   Country：Japan  

  • 腸管免疫の基盤、３型自然リンパ球. Invited

    @澤　新一郎

    第8回 オルソオルガノジェネシス研究会  2018.7 

    　More details

    Event date： 2018.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌市   Country：Japan  

  • 腸管免疫のゲートキーパー Invited

    @澤　新一郎

    第39回 日本炎症・再生医学会  2018.7 

    　More details

    Event date： 2018.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京都新宿区   Country：Japan  

  • ３型自然リンパ球は本当に腸管バリア機能の維持に重要か？

    @澤　新一郎

    第3回 ソニー ライフサイエンス学術セミナー  2018.7 

    　More details

    Event date： 2018.7

    Language：Japanese  

    Venue：東京都品川区   Country：Japan  

  • Fetal osteoclast inducer cells play a role in bone marrow cavity development.

    @Sumimya E., Nakano K., Okamura T. and @Sawa S.

    2018.6 

    　More details

    Event date： 2018.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Intestinal homeostasis maintained by subepithelial mesenchymal cell. Invited International conference

    @Sawa S, @Eriko Sumiya and Nagashima K

    2018.6 

    　More details

    Event date： 2018.5 - 2018.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

▼display all

MISC

  • 腸管免疫バリア形成における３型自然リンパ球の役割

    澤　新一郎

    臨床免疫・アレルギー科   2023.6

    　More details

    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

Industrial property rights

Patent   Number of applications: 3   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Japanese Society for Immunology

  • The Japanese Society of Inflammation and Regeneration

  • Japanese Pediatric Society

  • Japan Medical Association

  • The Japanese Society for Bone and Mineral Reserch

  • Kyoto T cell Conference

▼display all

Committee Memberships

  • 日本免疫学会   ダイバーシティ・キャリア支援委員会　委員長   Domestic

    2024.4 - 2026.3   

  • Councilor   Domestic

    2023.4 - 2026.3   

  • 日本免疫学会   キャリア・ダイバーシティ委員会　副委員長   Domestic

    2023.4 - 2026.3   

  • 日本免疫学会   広報委員   Domestic

    2023.1 - 2024.12   

  • Councilor   Domestic

    2022.6 - 2023.3   

  • 日本免疫学会   キャリアパス・男女共同参画委員   Domestic

    2022.6 - 2023.3   

  • 日本免疫学会   キャリアパス・男女共同参画委員会　委員   Domestic

    2022.4 - 2024.3   

  • Councilor   Domestic

    2021.4 - 2025.3   

  • 日本免疫学会   広報委員   Domestic

    2021.4 - 2025.3   

  • 日本免疫学会   広報委員   Domestic

    2021.1 - 2022.12   

  • 阿蘇シンポジウム   世話人   Domestic

    2019.10 - 2030.9   

  • Councilor   Domestic

    2019.1 - 2024.12   

  • Kyoto T cell conference (KTCC)   Steering committee member   Domestic

    2013.8 - 2030.7   

▼display all

Academic Activities

  • エッセンシャル免疫学 第4版

    2023.4 - 2023.12

    　More details

    Type：Academic society, research group, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2023

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：5

  • 当番世話人

    第42回阿蘇シンポジウム  （ 熊本城シビックホール（Hybrid形式） ） 2022.7

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：1,000

  • Frontiers in Immunology International contribution

    Role(s)： Peer review

    2022.1 - 2023.12

    　More details

    Type：Academic society, research group, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2022

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：5

  • シンポジウム座長 International contribution

    第48回日本免疫学会学術集会  （ アクトシティ浜松 ） 2019.12 - 2020.12

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：2,000

  • Screening of academic papers

    Role(s)： Peer review

    2019

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：8

  • ワークショップ　オーガナイザー、座長 International contribution

    第46回日本免疫学会学術集会  （ 仙台国際会議場 ） 2018.12

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：3,000

  • オーガナイザー International contribution

    （ 伊藤国際交流センター（東京） ） 2018.11 - 2018.12

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：300

  • Screening of academic papers

    Role(s)： Peer review

    2018

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

    Proceedings of International Conference Number of peer-reviewed papers：35

  • Screening of academic papers

    Role(s)： Peer review

    2017

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

    Proceedings of domestic conference Number of peer-reviewed papers：15

  • ワークショップ　座長 International contribution

    第45回日本免疫学会学術集会  （ 沖縄コンベンションセンター ） 2016.12

    　More details

    Type：Competition, symposium, etc. 

    Number of participants：2,000

▼display all

Research Projects

  • ILC3による腸管免疫記憶の形成および維持機構の解明

    Grant number：23H02737  2023 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • ３型自然リンパ球に関する研究

    2022.12 - 2024.12

    受託研究

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • カイコ昆虫モダリティによる低価格な国産組換えワクチンに関する研究開発

    2022.10 - 2027.3

    AMED-SCARDA ワクチン・新規モダリティ研究開発事業 

    　 More details

    Authorship：Coinvestigator(s) 

  • 自然免疫系リンパ球に関する研究

    2022.4 - 2023.3

    受託研究

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • カイコ昆虫モダリティによる低価格な国産組換えワクチンに関する研究開発

    2022 - 2026

    AMED SCARDA ワクチン・新規モダリティ研究開発事業

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 自然リンパ球に関する研究

    2021.4 - 2022.3

    受託研究

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • ３型自然リンパ球を用いた粘膜バリア増強療法への挑戦

    Grant number：21K19486  2021 - 2022

    日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • ムーンショット型研究　「ウイルス-人体相互作用ネットワークの理解と制御」

    2020.12 - 2025.11

    国立研究開発法人科学技術振興機構(JST) 

    　 More details

    Authorship：Coinvestigator(s) 

    ウイルスが感染した場合における個体内での応答様式を免疫系、特に免疫支持細胞に焦点をあてて解明する。当該年度では、ウイルス非感染および感染マウスにおける血管内皮、リンパ管内皮、線維芽細胞などの免疫支持細胞を採取し、シングルセルRNAシークエンシング解析（scRNA-seq）よる遺伝子発現パタンの抽出を試みる。これらのデータは他研究班が取得した免疫細胞やマイクロバイオームデータと統合し、数理系研究者のパタン分類整理に活用される。また、ウイルス感染に対する生体応答の鍵を握る分子の遺伝子改変マウス作成を開始する。

  • 2050年までに、超早期に疾患の予測・予防をすることができる社会を実現 ウイルス-人体相互作用ネットワークの理解と制御 ウイルス感染に対する免疫支持細胞の解析

    2020 - 2025

    科学技術振興費(主要5分野) (文部科学省)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Contract research

  • シングルセルレベルでの眼内増殖組織の活動性バイオマーカー検索

    Grant number：20K09829  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 活性型自然リンパ球による腸管免疫寛容に関する研究

    2019.10 - 2023.3

    国立研究開発法人日本医療研究開発機構（日本） 

    　 More details

    Authorship：Principal investigator 

    本邦ではアレルギー疾患が急増しています。減感作療法は長期間のアレルギーの寛解維持が期待できる有望な治療法ですが、分子および細胞レベルの理解は進んでいません。本研究では統合エピゲノムの手法を用いて早期ライフステージにおける腸管自然リンパ球や制御性T細胞の機能的特徴を規定する分子基盤および小腸免疫寛容の誘導機構を証明し、減感作療法の科学的基盤に迫ります。

  • ILC3による液性免疫制御機構の解明

    Grant number：19H03483  2019 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 活性型自然リンパ球による腸管免疫寛容に関する研究

    2019 - 2022

    革新的先端研究開発支援事業 (AMED-PRIME)

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 腸管における ILC3 生理機能の網羅的解析

    2019

    持田記念研究助成金

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 3型自然リンパ球を利用した新規食物アレルギー予防法の開発

    2019

    公益財団法人 ニッポンハム食の未来財団　個人研究助成

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 免疫組織形成および機能維持に重要な間葉系細胞の同定

    2019

    公益財団法人 武田科学振興財団 2019 年度 生命科学研究助成

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 急性GVHDを予防する骨髄球系細胞の同定および制御機構の解明

    2019

    ブリストル・マイヤーズスクイブ 研究助成

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • Group 3 innate lymphoid cells（ILC3s）の生体内動態解析，ワクチン誘導効果とアレルギー制御効果の基礎検討

    2018.3 - 2019.3

    共同研究

    　 More details

    Authorship：Principal investigator  Grant type：Other funds from industry-academia collaboration

  • 一細胞から紐解く新生児の腸管免疫システム

    Grant number：18K19503  2018 - 2019

    日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 新生児消化器疾患発症機序の分子生物学的解明に向けた解析ワークフローの確立

    Grant number：17H04235  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 間葉系細胞からみた腸管免疫系制御メカニズムの解明

    2017 - 2019

    内藤記念科学奨励金・若手ステップアップ研究助成

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • 新生児腸内細菌叢形成メカニズムの解明

    2016.10 - 2020.3

    国立研究開発法人日本医療研究開発機構（日本） 

    　 More details

    Authorship：Principal investigator 

    新生児期は腸内細菌叢形成と宿主免疫系の開始点を理解するうえで極めて重要な時期と考えられるが、哺乳類の腸内細菌叢形成メカニズムはこれまでほとんど明らかになっていない。また、新生児期の腸内細菌叢異常が思春期以降に発症する炎症性腸疾患等の免疫異常の発症要因になる可能性についても不明な点が多い。
    　近年、申請者らを含む複数の研究グループによってヒトおよびマウス粘膜組織内に抗原受容体を持たないリンパ球群が同定され、自然リンパ球と命名された。自然リンパ球のうち、核内受容体RORgtを発現する自然リンパ球は３型自然リンパ球（ILC3）とよばれ、腸管上皮細胞の生存や抗菌ペプチド産生に重要なインターロイキン22（Interleukin=IL-22）を強力に産生する。興味深いことに、マウス新生仔腸管においては、獲得免疫系の細胞に先立ち、ILC3が腸管粘膜固有層に出現する。生直後の新生児腸管においてILC3は主要なリンパ球であり、IL-22を恒常的に産生している。
    　本研究では、ILC3こそが腸管上皮機能の維持や細菌叢の選択に重要な役割を果たす細胞群であるとの仮説を立て、ILC3のみを生体内から除去可能な新規マウスモデルや、ILC3機能維持に重要と考えられるIL-23産生性樹状細胞を欠失可能なマウスを用い、ILC3やI IL-23産生樹状細胞がマウス新生仔腸内細菌叢の形成に果たす役割を明らかにし、腸内細菌叢の錯乱が免疫異常の原因となり得るか、マウスモデルを用いて検証する。

  • 新生児腸内細菌叢形成メカニズムの解明

    2016 - 2019

    AMED-PRIME「微生物叢と宿主の相互作用・共生の理解と、それに基づく疾患発症のメカニズム解明」

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • ILC3研究の展開

    2016 - 2018

    日本学術振興会  卓越研究員事業

    　 More details

    Authorship：Principal investigator  Grant type：Joint research

  • 自然リンパ球前駆細胞の同定

    Grant number：15K15149  2015 - 2017

    科学研究費助成事業  挑戦的萌芽研究

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • RORγt陽性自然リンパ球を特異的に欠損するマウスの作成

    Grant number：25670228  2013 - 2014

    日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • ２次リンパ組織形成におけるマスター制御因子の同定

    Grant number：25111503  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 自然リンパ球に作用し、腸管恒常性維持に関与する内因性リガンドの同定

    Grant number：24117725  2012 - 2013

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

▼display all

Class subject

  • 医学研究特論Ⅱ

    2023.10 - 2024.3   Second semester

  • 生命医科学入門

    2023.10 - 2024.3   Second semester

  • 生体応答制御学

    2023.10 - 2024.3   Second semester

  • 粘膜防御学

    2023.4 - 2024.3   Full year

  • 免疫学

    2023.4 - 2023.9   First semester

  • 国際生命科学Ⅱ

    2023.4 - 2023.9   First semester

  • 国際医学Ⅱ

    2023.4 - 2023.9   First semester

  • 医学研究特論Ⅱ

    2022.10 - 2023.3   Second semester

  • 粘膜防御学

    2022.4 - 2023.3   Full year

  • 免疫学

    2022.4 - 2022.9   First semester

  • 国際医学II

    2022.4 - 2022.9   First semester

  • 国際生命科学Ⅱ

    2022.4 - 2022.9   First semester

  • 遺伝学

    2021.10 - 2022.3   Second semester

  • 生命医科学入門

    2021.10 - 2022.3   Second semester

  • 粘膜防御学

    2021.4 - 2022.3   Full year

  • 免疫学

    2021.4 - 2021.9   First semester

  • 医学研究特論II

    2020.10 - 2021.3   Second semester

  • 遺伝学

    2020.10 - 2021.3   Second semester

  • 粘膜防御学

    2020.4 - 2021.3   Full year

  • 免疫学

    2020.4 - 2020.9   First semester

  • 粘膜防御学

    2019.4 - 2020.3   Full year

  • 免疫学

    2019.4 - 2019.9   First semester

▼display all

FD Participation

  • 2024.4   Role：Participation   Title：「職場における落とし穴」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.2   Role：Participation   Title：令和３年度馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.12   Role：Participation   Title：医学系学府大学院ＦＤ「学術論文の購読と投稿とこれから」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.12   Role：Participation   Title：九州大学大学院医学系学府教育FD「医学研究と倫理(2)」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.12   Role：Participation   Title：令和元年度　九州大学大学院医学系学府教育ＦＤ「医学研究と倫理」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.4   Role：Participation   Title：平成３１年度 第１回全学ＦＤ（新任教員の研修）

    Organizer：University-wide

  • 2019.2   Role：Participation   Title：生体防御医学研究所ＦＤ（情報セキュリティ関連ＦＤ）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  新潟大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：5月 14日　４限目　免疫学講義

  • 2023  北海道大学　医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2024年 1月 5日 ２限目　　免疫学講義

  • 2023  新潟大学・医学部　免疫学特別講義  Classification:Part-time lecturer 

    Semester, Day Time or Duration：1学期　4月27日　4限目

  • 2023  東京医科歯科大学　難治性疾患研究所  Classification:Affiliate faculty  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2025年3月31日まで

  • 2022  北海道大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2022年　1月4日　2時限目　免疫学講義

  • 2022  新潟大学・医学部　免疫学特別講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2022年5月10日１時限目

  • 2021  北海道大学・医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2022年　1月5日　1時限目　免疫学講義

  • 2021  新潟大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：４月２８日（水）４限（14:50~16:20）

  • 2020  北海道大学・医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2021年1月6日2時限目

  • 2020  新潟大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  北海道大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：2020年1月14日2時限目

  • 2019  新潟大学・医学部医学科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：前期　免疫学特別講義　（2019年4月25日　3時限目）

  • 2018  北海道大学・医学部医学科  Classification:Faculty conurrently holding another post  Domestic/International Classification:Japan 

    Semester, Day Time or Duration：後期　免疫学講義（2019年1月10日　2時限目）

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Activities contributing to policy formation, academic promotion, etc.

  • 2020.4 - 2021.3   文部科学省　科学技術・学術政策研究所 科学技術予測センター

    科学技術分野の研究動向を専門的見地から報告

Acceptance of Foreign Researchers, etc.

  • Central South University

    Acceptance period： 2022.5 - 2023.5   （Period）：1 month or more

    Nationality：China

    Business entity：Foreign governments, foreign research institutes, international organizations

Travel Abroad

  • 2019.6

    Staying countory name 1：United Kingdom   Staying institution name 1：Fransis-Crick Institute

    Staying institution name 2：Birmingham University

  • 2012.10

    Staying countory name 1：Germany   Staying institution name 1：German Cancer Research Center (DKFZ)

  • 2011.6

    Staying countory name 1：Switzerland   Staying institution name 1：École polytechnique fédérale de Lausanne

  • 2006.9 - 2011.3

    Staying countory name 1：France   Staying institution name 1：Institute Pasteur

  • 1999.8

    Staying countory name 1：United States   Staying institution name 1：Trudeau institute

    Staying institution name 2：National Institute of Health

Year of medical license acquisition

  • 2000