Updated on 2024/07/28

Information

 

写真a

 
KUBOTA HIROYUKI
 
Organization
Medical Institute of Bioregulation Medical Research Center for High Depth Omics Professor
Joint Graduate School of Mathematics for Innovation (Joint Appointment)
Graduate School of Systems Life Sciences Department of Systems Life Sciences(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
School of Medicine Department of Medicine(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426433
External link

Degree

  • Science

Research History

  • 東京大学、助教・特任准教授

Research Interests・Research Keywords

  • Research theme:Trans-omics analysis of vital phenomenon

    Keyword:trans-omics analysis, systems biology

    Research period: 2014.4 - 2024.6

Papers

  • Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2. Reviewed International journal

    2003.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN2. Invited Reviewed International journal

    2001.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • GI domain-mediated association of the eukaryotic initiation factor 2α kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. Reviewed International journal

    2000.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • DNA hypomethylation characterizes genes encoding tissue-dominant function proteins in liver and skeletal muscle. Reviewed International journal

    Maehara H., Kokaji T., Hatano A., Suzuki Y., Matsumoto M., Nakayama I.K., Egami R., Tsuchiya T., Ozaki H., Morita K., Shirai M., Li D., Terakawa A., Uematsu S., Hironaka K., Ohno S., Kubota H., Araki H., Miura F., Ito T., Kuroda S.

    Sci Rep.   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Comparison of hepatic responses to glucose perturbation between normal and obese mice using edge type. Reviewed International journal

    Ito Y., Uda S., Kokaji T., Suzuki Y., Hirayama A., Soga T., Kuroda S., Kubota H.

    Scientific Reports   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states. Reviewed International journal

    Kokaji T., Eto M., Hatano A., Yugi K., Morita K., Ohno S., Fujii M., Hironaka K., @Ito Y., Egami R., Uematsu S., Terakawa A., Pan Y., Maehara H., Li D., Bai Y., Tsuchiya T., Ozaki H., Inoue H., @Kubota H., Suzuki Y., Hirayama A., Soga T., Kuroda S.

    Scientific Reports   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-17964-9

  • Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans. Reviewed International journal

    @Fujita S., @Karasawa Y., @Fujii M., @Hironaka K. I., Uda S., Kubota H., @Inoue H., @Sumitomo Y., @Hirayama A., @Soga T. and @Kuroda S.

    npj Systems Biology & Applications   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1038/s41540-022-00213-0

  • Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism. Reviewed International journal

    @Uematsu S., @Ohno S., @Tanaka K., @Hatano A., @Kokaji T., Ito Y., Kubota H., @Hironaka K., @Suzuki Y., Matsumoto M., Nakayama K., @Hirayama A., @Soga T. and K@uroda S.

    iScience   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1016/j.isci.2022.103787

  • An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver. International journal

    Fumiko Matsuzaki, Shinsuke Uda, Yukiyo Yamauchi, Masaki Matsumoto, Tomoyoshi Soga, Kazumitsu Maehara, Yasuyuki Ohkawa, Keiichi I Nakayama, Shinya Kuroda, Hiroyuki Kubota

    Cell reports   36 ( 8 )   109569 - 109569   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2021.109569

  • Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle

    Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda

    iScience   24 ( 3 )   102217 - 102217   2021.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2021.102217

  • Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity. International journal

    Toshiya Kokaji, Atsushi Hatano, Yuki Ito, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Riku Egami, Akira Terakawa, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Kazutaka Ikeda, Makoto Arita, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda

    Science signaling   13 ( 660 )   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scisignal.aaz1236

  • Single-Cell Information Analysis Reveals That Skeletal Muscles Incorporate Cell-to-Cell Variability as Information Not Noise. Reviewed International journal

    Wada T, Hironaka K, Wataya M, Fujii M, Eto M, @Uda S, Hoshino D, Kunida K, Inoue H, @Kubota H, Takizawa T, Karasawa Y, Nakatomi H, Saito N, Hamaguchi H, Furuichi Y, Manabe Y, Fujii NL, and Kuroda S.

    Cell reports   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016

  • Single-Cell Information Analysis Reveals That Skeletal Muscles Incorporate Cell-to-Cell Variability as Information Not Noise. Reviewed International journal

    Takumi Wada, Ken-Ichi Hironaka, Mitsutaka Wataya, Masashi Fujii, Miki Eto, Shinsuke Uda, Daisuke Hoshino, Katsuyuki Kunida, Haruki Inoue, Hiroyuki Kubota, Tsuguto Takizawa, Yasuaki Karasawa, Hirofumi Nakatomi, Nobuhito Saito, Hiroki Hamaguchi, Yasuro Furuichi, Yasuko Manabe, Nobuharu L Fujii, Shinya Kuroda

    Cell reports   32 ( 9 )   108051 - 108051   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2020.108051

  • Biophysics at Kyushu University. Reviewed International journal

    Ryo Akiyama, Masahiko Annaka, Daisuke Kohda, Hiroyuki Kubota, Yusuke Maeda, Nobuaki Matsumori, Daisuke Mizuno, Norio Yoshida

    Biophysical reviews   12 ( 2 )   245 - 247   2020.4

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    Language:English  

    DOI: 10.1007/s12551-020-00643-2

  • Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Reviewed International journal

    Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama

    Cell reports   29 ( 9 )   2901 - 2916   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2019.10.079

  • Logical design of oral glucose ingestion pattern minimizing blood glucose in humans. Reviewed International journal

    Fujii M, Murakami Y, Karasawa Y, Sumitomo Y, Fujita S, Koyama M, @Uda S, @Kubota H, Inoue H, Konishi K, Oba S, Ishii S, Kuroda S.

    NPJ Syst Biol Appl.   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41540-019-0108-1.

  • Logical design of oral glucose ingestion pattern minimizing blood glucose in humans. Reviewed International journal

    Masashi Fujii, Yohei Murakami, Yasuaki Karasawa, Yohei Sumitomo, Suguru Fujita, Masanori Koyama, Shinsuke Uda, Hiroyuki Kubota, Hiroshi Inoue, Katsumi Konishi, Shigeyuki Oba, Shin Ishii, Shinya Kuroda

    NPJ systems biology and applications   5 ( 1 )   31 - 31   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41540-019-0108-1

  • Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data. Reviewed International journal

    Kentaro Kawata, Katsuyuki Yugi, Atsushi Hatano, Toshiya Kokaji, Yoko Tomizawa, Masashi Fujii, Shinsuke Uda, Hiroyuki Kubota, Masaki Matsumoto, Keiichi I Nakayama, Shinya Kuroda

    Genes to cells : devoted to molecular & cellular mechanisms   24 ( 1 )   82 - 93   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12655

  • In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver. Reviewed International journal

    7 ( 5 )   562 - 564   2018.11

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    Language:English  

    DOI: 10.1016/j.cels.2018.11.002

  • Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks. Reviewed International journal

    Kentaro Kawata, Atsushi Hatano, Katsuyuki Yugi, Hiroyuki Kubota, Takanori Sano, Masashi Fujii, Yoko Tomizawa, Toshiya Kokaji, Kaori Y Tanaka, Shinsuke Uda, Yutaka Suzuki, Masaki Matsumoto, Keiichi I Nakayama, Kaori Saitoh, Keiko Kato, Ayano Ueno, Maki Ohishi, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda

    iScience   7   212 - 229   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2018.07.022

  • In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver. Reviewed International journal

    7 ( 1 )   118 - 128   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cels.2018.05.013

  • Sparse Gaussian graphical model with missing values

    Shinsuke Uda, Hiroyuki Kubota

    21st Conference of Open Innovations Association, FRUCT 2017 Proceedings of the 21st Conference of Open Innovations Association, FRUCT 2017   Part F134240   336 - 343   2018.1

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    Language:English   Publishing type:Research paper (other academic)  

    DOI: 10.23919/FRUCT.2017.8250201

  • Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects Reviewed

    Kaoru Ohashi, Masashi Fujii, Shinsuke Uda, Hiroyuki Kubota, Hisako Komada, Kazuhiko Sakaguchi, Wataru Ogawa, Shinya Kuroda

    npj Systems Biology and Applications   4   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41540-018-0051-6

  • System identification of signaling dependent gene expression with different time-scale data. Reviewed International journal

    Takaho Tsuchiya, Masashi Fujii, Naoki Matsuda, Katsuyuki Kunida, Shinsuke Uda, Hiroyuki Kubota, Katsumi Konishi, Shinya Kuroda

    PLoS computational biology   13 ( 12 )   e1005913   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pcbi.1005913

  • Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin. Reviewed International journal

    Takanori Sano, Kentaro Kawata, Satoshi Ohno, Katsuyuki Yugi, Hiroaki Kakuda, Hiroyuki Kubota, Shinsuke Uda, Masashi Fujii, Katsuyuki Kunida, Daisuke Hoshino, Atsushi Hatano, Yuki Ito, Miharu Sato, Yutaka Suzuki, Shinya Kuroda

    Science signaling   9 ( 455 )   ra112   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scisignal.aaf3739

  • Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers Reviewed

    Katsuyuki Yugi, Hiroyuki Kubota, Atsushi Hatano, Shinya Kuroda

    TRENDS IN BIOTECHNOLOGY   34 ( 4 )   276 - 290   2016.4

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    Language:English  

    DOI: 10.1016/j.tibtech.2015.12.013

  • Trans-Omics How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers Reviewed

    Katsuyuki Yugi, Hiroyuki Kubota, Atsushi Hatano, Shinya Kuroda

    Trends in Biotechnology   34 ( 4 )   276 - 290   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tibtech.2015.12.013

  • Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system Reviewed

    Shinji Fukuda, Hisayo Nishida-Fukuda, Daisuke Nanba, Koh-ichi Nakashiro, Hironao Nakayama, Hiroyuki Kubota, Shigeki Higashiyama

    SCIENTIFIC REPORTS   6   20209   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep20209

  • Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system Reviewed

    Shinji Fukuda, Hisayo Nishida-Fukuda, Daisuke Nanba, Koh Ichi Nakashiro, Hironao Nakayama, Hiroyuki Kubota, Shigeki Higashiyama

    Scientific Reports   6   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep20209

  • Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans Reviewed

    Kaoru Ohashi, Hisako Komada, Shinsuke Uda, Hiroyuki Kubota, Toshinao Iwaki, Hiroki Fukuzawa, Yasunori Komori, Masashi Fujii, Yu Toyoshima, Kazuhiko Sakaguchi, Wataru Ogawa, Shinya Kuroda

    PLOS ONE   10 ( 12 )   e0143880   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0143880

  • Glucose homeostatic law Insulin clearance predicts the progression of glucose intolerance in humans Reviewed

    Kaoru Ohashi, Hisako Komada, Shinsuke Uda, Hiroyuki Kubota, Toshinao Iwaki, Hiroki Fukuzawa, Yasunori Komori, Masashi Fujii, Yu Toyoshima, Kazuhiko Sakaguchi, Wataru Ogawa, Shinya Kuroda

    PLoS One   10 ( 12 )   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0143880

  • An optogenetic system for interrogating the temporal dynamics of Akt Reviewed

    Yoshihiro Katsura, Hiroyuki Kubota, Katsuyuki Kunida, Akira Kanno, Shinya Kuroda, Takeaki Ozawa

    SCIENTIFIC REPORTS   5   14589   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep14589

  • An optogenetic system for interrogating the temporal dynamics of Akt Reviewed

    Yoshihiro Katsura, Hiroyuki Kubota, Katsuyuki Kunida, Akira Kanno, Shinya Kuroda, Takeaki Ozawa

    Scientific Reports   5   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep14589

  • Temporal coding of insulin signaling

    Hiroyuki Kubota, Shinya Kuroda

    Protein Modifications in Pathogenic Dysregulation of Signaling   95 - 109   2015.9

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    Language:English  

    DOI: 10.1007/978-4-431-55561-2_7

  • Reconstruction of insulin signal flow from phosphoproteome and metabolome data Reviewed International journal

    2014.8

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  • Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data Reviewed

    Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, Shinya Kuroda

    CELL REPORTS   8 ( 4 )   1171 - 1183   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2014.07.021

  • The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression Reviewed

    Yuki Akimoto, Katsuyuki Yugi, Shinsuke Uda, Takamasa Kudo, Yasunori Komori, Hiroyuki Kubota, Shinya Kuroda

    PLOS ONE   8 ( 9 )   e72780   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0072780

  • Robustness and Compensation of Information Transmission of Signaling Pathways Reviewed

    Shinsuke Uda, Takeshi H. Saito, Takamasa Kudo, Toshiya Kokaji, Takaho Tsuchiya, Hiroyuki Kubota, Yasunori Komori, Yu-ichi Ozaki, Shinya Kuroda

    SCIENCE   341 ( 6145 )   558 - 561   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1234511

  • The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns. Reviewed International journal

    Rei Noguchi, Hiroyuki Kubota, Katsuyuki Yugi, Yu Toyoshima, Yasunori Komori, Tomoyoshi Soga, Shinya Kuroda

    Molecular systems biology   9   664 - 664   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/msb.2013.19

  • Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway Reviewed

    Hiroyuki Kubota, Rei Noguchi, Yu Toyoshima, Yu-ichi Ozaki, Shinsuke Uda, Kanako Watanabe, Wataru Ogawa, Shinya Kuroda

    MOLECULAR CELL   46 ( 6 )   820 - 832   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molcel.2012.04.018

  • Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics Reviewed

    Kazuhiro A. Fujita, Yu Toyoshima, Shinsuke Uda, Yu-Ichi Ozaki, Hiroyuki Kubota, Shinya Kuroda

    Science Signaling   3 ( 132 )   ra56   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scisignal.2000810

  • Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics Reviewed

    Kazuhiro A. Fujita, Yu Toyoshima, Shinsuke Uda, Yu-ichi Ozaki, Hiroyuki Kubota, Shinya Kuroda

    SCIENCE SIGNALING   3 ( 132 )   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scisignal.2000810

  • A Quantitative Image Cytometry Technique for Time Series or Population Analyses of Signaling Networks Reviewed

    Yu-ichi Ozaki, Shinsuke Uda, Takeshi H. Saito, Jaehoon Chung, Hiroyuki Kubota, Shinya Kuroda

    PLOS ONE   5 ( 3 )   e9955   2010.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0009955

  • Timing-Dependent Actions of NGF Required for Cell Differentiation. Reviewed International journal

    Chung J., Kubota H., Ozaki Y., Uda S., and Kuroda, S.

    PLoS ONE   2010.2

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  • Timing-Dependent Actions of NGF Required for Cell Differentiation Reviewed

    Jaehoon Chung, Hiroyuki Kubota, Yu-ichi Ozaki, Shinsuke Uda, Shinya Kuroda

    PLOS ONE   5 ( 2 )   e9011   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0009011

  • The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR inactivation. Reviewed International journal

    Matsuo R., Kubota H., Obata T., Kito K., Ota K., Kitazono T., Ibayashi S., Sasaki T., Iida M., and Ito T.

    FEBS Lett.   2005.4

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  • The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation Reviewed

    R Matsuo, H Kubota, T Obata, K Kito, K Ota, T Kitazono, S Ibayashi, T Sasaki, M Iida, T Ito

    FEBS LETTERS   579 ( 11 )   2433 - 2438   2005.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.febslet.2004.03.043

  • Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Reviewed International journal

    Ichimura T., Kubota H., Goma T., Mizushima N., Ohsumi Y., Iwago M., Kakiuchi K., Shekhar H. U., Shinkawa T., Taoka M, Ito T., and Isobe T.

    Biochemistry   2004.10

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  • Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast Reviewed

    T Ichimura, H Kubota, T Goma, N Mizushima, Y Ohsumi, M Iwago, K Kakiuchi, HU Shekhar, T Shinkawa, M Taoka, T Ito, T Isobe

    BIOCHEMISTRY   43 ( 20 )   6149 - 6158   2004.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bi03542li

  • Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2. Reviewed

    278 ( 23 )   20457 - 20460   2003.6

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    Language:Others  

    DOI: 10.1074/jbc.C300133200

  • Roles for the two-hybrid system in exploration of the yeast protein interactome. Reviewed International journal

    Ito T., Ota K., Kubota H., Yamaguchi Y., Chiba T., Sakuraba K., and Yoshida M.

    Mol. Cell. Proteomics   2002.8

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  • Roles for the two-hybrid system in exploration of the yeast protein interactome Reviewed

    T Ito, K Ota, H Kubota, Y Yamaguchi, T Chiba, K Sakuraba, M Yoshida

    MOLECULAR & CELLULAR PROTEOMICS   1 ( 8 )   561 - 566   2002.8

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    Language:English  

    DOI: 10.1074/mcp.R200005-MCP200

  • Budding yeast GCN1 binds the GI domain to activate the eIF2α kinase GCN2.

    276 ( 20 )   17591 - 17596   2001.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M011793200

  • GI domain-mediated association of the eukaryotic initiation factor 2α kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast.

    275 ( 27 )   20243 - 20246   2000.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.C000262200

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Books

  • 時系列のマルチオミクス解析による生命現象の理解

    久保田 浩行( Role: Sole author)

    羊土社  2023.12 

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    Responsible for pages:Vol.42,No.1   Language:Japanese   Book type:Scholarly book

  • 久保田浩行

    久保田浩行( Role: Sole author)

    丸善  2022.6 

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    Language:Japanese   Book type:Scholarly book

  • 松﨑 芙美子、久保田 浩行

    松﨑 芙美子、久保田 浩行( Role: Joint author)

    技術情報協会  2022.3 

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    Language:Japanese   Book type:Scholarly book

  • 久保田浩行

    久保田浩行( Role: Joint author)

    オーム社  2021.12 

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    Language:Japanese   Book type:Scholarly book

  • 生物をシステムとして理解する‐細胞とラジオは同じ!?‐

    久保田 浩行( Role: Sole author)

    共立出版  2018.7 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • トランスオミクス解析:次なるシグナリング研究を担えるか?

    久保田 浩行, 黒田 真也, 柚木 克之( Role: Joint author)

    羊土社  2015.6 

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    Language:Japanese   Book type:Scholarly book

  • Protein Modifications in Pathogenic Dysregulation of Signaling

    ( Role: Joint author)

    Springer 

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    Language:English   Book type:Scholarly book

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Presentations

  • Revealing of time- and layer-dependent metabolic regulatory mechanisms by the trans-omic analysis. Invited International conference

    Kubota Hiroyuki

    The 41st Sapporo International Cancer Symposium  2023.10 

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    Event date: 2024.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • トランスオミクス解析を用いたインスリン作用の理解 Invited

    久保田 浩行

    日本心血管内分泌代謝学会  2018.4 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:宮崎   Country:Japan  

    ある疾患など同一の生命現象を理解するために、多くの研究者が異なる少数の分子に注目して研究を行ってきた。そして、これらの結果をパッチワークのように張り合わせることでその生命現象を理解するという、帰納的なアプローチを主流として生命科学が発展してきた。しかし、このような帰納的なアプローチでは生命現象それ自体ではなく実験系などに依存した結果を得ることがある。実際に、多くの研究者が他の研究者の実験結果を再現できないということを経験してきたと思う。また、同じ生命現象に注目していても十分な情報が得られていないため、実験結果の解釈が異なる場合もある。
    一方で、計測技術の進歩により、大量のデータから生命現象を理解するという演繹的なアプローチも数多く行われるようになってきた。「~オミクス」と呼ばれる網羅的な計測アプローチである。しかし、このような網羅的な計測で最もよく行われるのは「スクリーニング」であり、これらのデータから仮説を直接構築することはあまり行われていない。この理由として、得られたオームデータを十分に説明することができないことが挙げられる。
    さて、疾患をはじめとする生命現象は限られた少数の分子によって制御されるのではなく、DNA(ゲノム)やRNA(トランスクリプトーム)、タンパク質(プロテオーム)、代謝物(メタボローム)など、複数のオミクス階層にまたがる複雑なネットワークによって制御されている。つまり、生命現象の全体像を理解するためには複数のオミクス階層を統合し、理解する必要がある。もし、研究者のバイアスなしに複数のオミクス階層を統合し、多階層にまたがるネットワークを同定できたなら、上記で述べた問題点を解決できるパワフルなアプローチになると期待される。我々は、アンバイアスな統合手法、「トランスオミクス解析」の確立とその手法の有用性を示すため、インスリン作用に注目して研究を行っている。
    本発表では2つのトランスオミクス解析についてお話しする予定である。一つは、培養細胞を用いて1時間以内の短期インスリン作用に注目した研究である。この研究で我々は、リン酸化プロテオームとメタボロームの実験データと、複数のデータベースを用いることで、これらの階層にまたがる大規模なネットワークを同定することに成功した。この結果、既知のネットワーク以外に新規のネットワークも同定することに成功した。また、インスリンがどのように代謝を制御しているかという全体像を垣間見ることが出来た。もう一つは、マウスの肝臓を用いたインスリン作用のトランスオミクス解析についてである。これはまだ解析の途中ではあるが、今後の疾患研究へ向けた一つの方向性としてご紹介したい。

  • インスリンパターンによる生体内シグナル分子の選択的制御 Invited

    久保田 浩行、宇田 新介、松崎 芙美子、山内 幸代、黒田 真也

    生命科学系学会合同年次大会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • Trans-Omic analysis of the acute insulin action in the liver =Toward in vivo trans-omic analysis Invited International conference

    Kubota H., Uda S., Matsuzaki F., Kuroda S

    The 1st International Symposium for Trans-Omics  2017.11 

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    Event date: 2017.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Toward in vivo Trans-omic analysis Invited

    2016.7 

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    Event date: 2016.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Reconstruction of insulin signal flow from phospho-proteome and metabolome data Invited International conference

    International Symposium on Synthetic Systems Biology  2015.9 

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    Event date: 2015.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 生物と数理科学的手法を用いて肥満の進行を多面的に理解する Invited

    久保田 浩行

    日本生化学会  2023.10 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • トランスオミクス解析による疾患発症過程の理解 Invited

    久保田 浩行

    日本メディカルAI学会  2023.6 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • トランスオミクス解析による生命現象の理解 Invited

    久保田浩行

    最先端バイオインフォマティクス研究ミニシンポジウム  2022.11 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:on line   Country:Japan  

  • Trans-omic analysis of inulin response in the liver. Invited International conference

    2. Matsuzaki F., Uda S., Yamauchi Y., Matumoto M., Soga T., Maehara K., Ohkawa Y., Nakayama K. I., Kuroda S., Kubota H.

    The 31st Hot Spring Harbor International Symposium, Online  2022.11 

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    Event date: 2022.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Trans-omic analysis of obesity revealed time-dependent regulation across multiple omic layer. Invited International conference

    1. Kubota H.

    The 31st Hot Spring Harbor International Symposium  2022.11 

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    Event date: 2022.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Trans-omic analysis of insulin response in the liver. Invited International conference

    Matsuzaki F., Uda S., Yamauchi Y., Kubota H.

    International Symposium on Evolutionary Genomics and Bioinformatics 2022  2022.3 

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    Event date: 2022.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • トランスオミクス解析を用いたマウス肝臓におけるインスリン作用の全体像の理解 Invited

    2. 久保田 浩行

    第3回日本メディカルAI学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:on line   Country:Japan  

  • トランスオミクス解析を用いた疾患の理解 Invited

    久保田 浩行

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:on line   Country:Japan  

  • Comparison of hepatic responses to glucose perturbation between normal and obese mice using edge ontology. International conference

    @Yuki Ito, @Shinsuke Uda, Toshiya Kokaji, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, @Shinya Kuroda and @Hiroyuki Kubota

    Fusion of Mathematics and Biology  2020.10 

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    Event date: 2020.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Selective regulation of the Insulin-AKT pathway by simultaneous processing of blood insulin pattern in the liver. Invited International conference

    Hiroyuki Kubota

    Fusion of Mathematics and Biology  2020.10 

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    Event date: 2020.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 時系列トランスオミクス解析

    @松崎 芙美子、@宇田 新介、@山内 幸代、@松本 雅記、曽我 朋義、@前原 一満、@@大川 恭行、@中山 敬一、黒田 真也、@久保田 浩行

    第42回分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Time Series Transomics: Integrated analysis through multiple molecular layers International conference

    @Fumiko Matsuzaki, @Shinsuke Uda, @Yukiyo Yamauchi, @Masaki Matsumoto, Tomoyoshi Soga, @Kazumitsu Maehara, @Yasuyuki Ohkawa, @Keiichi I. Nakayama, Shinya Kuroda, @Hiroyuki Kubota

    ICSB  2019.11 

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    Event date: 2019.11

    Language:English  

    Country:Japan  

  • Regulation of insulin action by temporal patterns of insulin Invited

    2019.12 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Regulation of insulin action by temporal patterns of insulin Invited

    Hiroyuki Kubota

    2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • トランスオミクス解析を用いたインスリン作用の理解 Invited

    久保田 浩行

    第22回日本心血管内分泌代謝学会  2018.4 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:宮崎   Country:Japan  

  • Selective control of the Insulin-AKT pathway by simultaneous processing of blood insulin in the liver Invited International conference

    Hiroyuki Kubota

    1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks  2019.2 

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    Event date: 2019.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • In vivo decoding mechanisms of the temporal patterns of blood insulin by the insulin-AKT pathway in the liver. Invited International conference

    Hiroyuki Kubota

    2019.2 

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    Event date: 2019.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 単純なネットワーク構造と入力刺激パターンが生み出す生命応答の制御 Invited

    久保田 浩行

    2018.8 

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    Event date: 2018.8 - 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大津   Country:Japan  

  • 個体を丸ごと理解する‐in vivoトランスオミクス解析を目指して- Invited

    久保田 浩行, 宇田 新介, 松﨑 芙美子

    トランスオミクスによる生命システムの解明  2016.3 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Transomics analysis of acute insulin action: network reconstruction from multi-omics data Invited International conference

    The 25th Hot Spring Harbor International Symposium  2015.11 

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    Event date: 2015.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Reconstruction of insulin signal flow from phosphoproteome and metabolome data Invited International conference

    2nd International Symposium on Protein Modification in Pathogenic Dysregulation of Signaling  2015.1 

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    Event date: 2015.1

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • インスリン作用のトランスオミクス解析 Invited

    久保田 浩行, 柚木 克之, 黒田 真也

    日本プロテオーム学会  2014.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:筑波   Country:Japan  

    生物は限られた少数の分子によって制御されるのではなく、DNA(ゲノム)やRNA(トランスクリプトーム)、タンパク質(プロテオーム)、代謝物(メタボローム)など、複数のオミクス階層にまたがるネットワークによって制御されている。つまり、細胞(生物)の理解には複数のオミクス階層を「統合」し、「理解」する必要がある(トランスオミクス解析)。一方で、近年の網羅的計測技術の進歩により、各階層において高精度の網羅的データが取得できるようになってきた。つまり、ようやくトランスオミクス解析が行える環境が整ってきたと考えられる。我々は、主にリン酸化シグナルによって代謝が調節されると考えられる短時間(1時間)のインスリン応答に注目し、同一条件で刺激した細胞からリン酸化プロテオー
    ム(九大、中山・松本先生)とメタボローム(慶応、曽我先生)を測定して頂き、トランスオミクス解析を行った。実験データと3 つのデータベース(KEGG, NetPhorest,BRENDA)を用いることで、主観を排除した解析を行い、インスリンの入力から代謝制御までのネットワークを推定することに成功した。トランスオミクス解析で予測された新規の代謝制御に注目して検証実験を行ったところ、リン酸化によって制御された代謝酵素による、新規の代謝調節経路を見出した。この結果、本手法が十分な予測精度を持つことが示された。今後、このようなトランスオミクス解析
    が、複数のオミクス解析のアプリケーションになることを期待する。

  • Temporal Coding of Insulin Action through Multiplexing of AKT Pathway Invited

    2014.6 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • インスリン作用の解明にむけたシステム生物学的アプローチ Invited

    久保田 浩行

    2014.6 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛   Country:Japan  

    実験とコンピュータ解析を合わせたシステム生物学により、直観や経験では分からなかった生物の特性が明らかになってきています。現在我々は、システム生物学的アプローチを用いてインスリン作用の研究を行っています。インスリンはリン酸化や遺伝子発現、代謝などの「階層」を介して細胞の応答を制御しています。また、血中インスリンの時間パターンはいくつかのパターンからなることが知られており、生体のホメオスタシスに重要であることが知られています。我々は、「階層」をまたぐ全体像を明らかにするトップダウンと、時間パターンに注目した作用メカニズムを明らかにするボトムアップのアプローチを用いて研究を行っています。本講演では、これらの2つの研究を中心に、我々が現在行っているいくつかの研究内容についてご紹介したいと思います。

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MISC

  • システム生物学 -数理科学を用いる「いろは」とめざすもの-

    久保田 浩行

    2017.6

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    Language:Japanese  

  • トランスオミックス解析の現状

    久保田 浩行

    2020.3

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    Language:Japanese  

  • Single-cell information analysis reveals small intra- and large intercellular variations increase cellular information capacity

    Wada T, Wataya M, Fujii M, Hironaka K, Eto M, Uda S, Hoshino D, Kunida K, Inoue H, Kubota H, Hamaguchi H, Furuichi Y, Manabe Y, Fujii N, Kuroda S

    bioRxiv   2019.5

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    Language:Others  

    Single-cell information analysis reveals small intra- and large intercellular variations increase cellular information capacity

  • 血中インスリン濃度パターンによる肝臓シグナル分子の選択的制御

    久保田浩行 黒田真也

    2018.4

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    Language:Japanese  

  • トランスオミクス解析が暴き出す相互作用ネットワークの全体像,

    久保田 浩行,黒田 真也

    医学のあゆみ   2016.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • トランスオミクス研究の新展開-階層統合の最新動向、そして次に来るもの-

    柚木 克之,久保田 浩行,黒田 真也

    羊土社, 実験医学   2016.10

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  • トランスオミクス研究の新展開

    久保田 浩行, 柚木 克之, 幡野 敦, 黒田 真也

    実験医学   2016.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Temporal coding of insulin signaling

    Hiroyuki Kubota, Shinya Kuroda

    Protein Modifications in Pathogenic Dysregulation of Signaling   2015.9

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    Language:English  

    DOI: 10.1007/978-4-431-55561-2_7

  • トランスオミクス解析:次なるシグナリング研究を担えるか?

    久保田 浩行, 柚木 克之, 黒田 真也

    実験医学増刊号   2015.5

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  • トランスオミクス解析:マルチオミクスデータから代謝制御ネットワークを再構築する

    久保田 浩行, 柚木 克之, 黒田 真也

    バイオサイエンスとインダストリー   2015.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Academic Activities

  • 座長

    ムーンショットシンポジウム  2023.4

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    Type:Competition, symposium, etc. 

    Number of participants:120

  • 主催者 International contribution

    2022.11 - 2023.6

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Chairman International contribution

    1. Fusion of Mathematics and Biology  ( on line Japan ) 2020.10

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    Type:Competition, symposium, etc. 

    Number of participants:200

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

  • 座長 International contribution

    ( 東京 ) 2019.2

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    Type:Competition, symposium, etc. 

    Number of participants:100

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • 座長 International contribution

    ( 福岡 ) 2018.10 - 2019.10

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • 座長(Chairmanship) International contribution

    ( 東京大学医科学研究所 ) 2015.1

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    Type:Competition, symposium, etc. 

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Research Projects

  • 老化研究支援・推進に関する研究開発

    2022.10 - 2029.3

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    Authorship:Coinvestigator(s) 

  • 患者主体データの統合解析・発症・甲順・転移のネットワーク解析

    2020.12 - 2025.11

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    Authorship:Principal investigator 

  • 脂肪肝進行の時系列トランスオミクス解析による理解

    2020.4 - 2023.3

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    Authorship:Principal investigator 

  • 患者生体データの統合解析を通じた発症・浸潤・転移のネットワーク解析

    2020 - 2025

    ムーンショット

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    Authorship:Principal investigator  Grant type:Contract research

  • 脂肪肝進行の時系列トランスオミクス解析による理解

    Grant number:20H03237  2020 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 定量的光操作と計測技術を基軸とする生体深部の細胞応答ダイナミクスの解析

    2017.10 - 2023.3

    受託研究

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    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 定量的光操作と計測技術を基軸とする生体深部の細胞応答ダイナミクスの解析

    2017.10 - 2023.3

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    Authorship:Coinvestigator(s) 

  • 定量的光操作と計測技術を基盤とする生体深部の細胞応答ダイナミクスの解析

    Grant number:JPMJCR1752  2017 - 2023

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 多階層に跨る生体シグナル伝達システムの数理解析

    2016.7 - 2021.3

    日本 

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    Authorship:Principal investigator 

    生体内におけるインスリン作用の多階層ネットワークを明らかにし、その特性を数理モデルを作成することで明らかにする

  • 多階層に跨る生体シグナル伝達システムの数理解析

    Grant number:16H06577  2016 - 2020

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • インスリンシグナリングにおける時間情報コードのシステム解析

    2014.4 - 2017.4

    共同研究

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Other funds from industry-academia collaboration

  • 生体における動的恒常性維持・変容機構の解明と制御

    2013.10 - 2017.3

    日本 

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    Authorship:Principal investigator 

    生体内における時間情報コードの存在を、インスリン作用に注目し実験とモデルを用いることで明らかにする。

  • 血中インスリンの時間パターンによる恒常性維持機構の解明

    Grant number:123364  2013 - 2016

    科学研究費助成事業  さきがけ

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 数理モデルを用いた入力刺激パターンからの修飾シグナル病の理解

    Grant number:25117712  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Class subject

  • 最新トピックスから学ぶ生命科学入門

    2024.10 - 2025.3   Second semester

  • Medical Life Science Special Lecture

    2024.10 - 2025.3   Second semester

  • 生命医科学特別講義

    2024.10 - 2025.3   Second semester

  • 生命医科学特論Ⅱ

    2024.6 - 2024.8   Summer quarter

  • Topics in medical life sciences Ⅱ

    2024.6 - 2024.8   Summer quarter

  • 生命医科学Ⅰ

    2024.4 - 2024.6   Spring quarter

  • Medical Life Sciences Ⅰ

    2024.4 - 2024.6   Spring quarter

  • 生命医科学特論Ⅰ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅰ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅳ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅳ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅲ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅲ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅱ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅱ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅰ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅰ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅳ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅳ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅲ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅲ

    2023.6 - 2023.8   Summer quarter

  • Topics in medical life sciences Ⅱ

    2023.6 - 2023.8   Summer quarter

  • 生命医科学特論Ⅱ

    2023.6 - 2023.8   Summer quarter

  • 最新トピックスから学ぶ生命科学入門

    2023.4 - 2023.9   First semester

  • Medical Life Sciences Ⅱ

    2023.4 - 2023.6   Spring quarter

  • 生命医科学Ⅱ

    2023.4 - 2023.6   Spring quarter

  • Medical Life Sciences Ⅰ

    2023.4 - 2023.6   Spring quarter

  • 生命医科学Ⅰ

    2023.4 - 2023.6   Spring quarter

  • Medical Life Sciences Ⅱ

    2023.4 - 2023.6   Spring quarter

  • 生命医科学Ⅱ

    2023.4 - 2023.6   Spring quarter

  • Topics in medical life sciences Ⅱ

    2022.6 - 2022.8   Summer quarter

  • 生命医科学特論Ⅱ

    2022.6 - 2022.8   Summer quarter

  • 最新トピックスから学ぶ生命科学入門

    2022.4 - 2022.9   First semester

  • 生命医科学Ⅰ

    2022.4 - 2022.6   Spring quarter

  • Medical Life Sciences Ⅰ

    2022.4 - 2022.6   Spring quarter

  • 数学共創概論Ⅰ

    2021.4 - 2021.9   First semester

  • 生命医科学I

    2021.4 - 2021.9   First semester

  • 生命医科学Ⅰ

    2021.4 - 2021.6   Spring quarter

  • Medical Life Sciences Ⅰ

    2021.4 - 2021.6   Spring quarter

  • 生命医科学I

    2020.4 - 2020.9   First semester

  • 生命医科学特論

    2020.4 - 2020.9   First semester

  • 最新トピックスから学ぶ生命科学入門Ⅱ

    2019.12 - 2020.2   Winter quarter

  • 生命医科学特別講義

    2019.4 - 2019.6   Spring quarter

  • 生命医科学特論Ⅳ

    2019.4 - 2019.6   Spring quarter

  • 生命医科学特論Ⅳ

    2018.12 - 2019.2   Winter quarter

  • 最新トピックスから学ぶ生命科学入門Ⅱ

    2018.10 - 2019.3   Second semester

  • 生命医科学特別講義

    2018.4 - 2018.6   Spring quarter

  • 最新トピックスから学ぶ生命科学入門Ⅳ

    2017.12 - 2018.2   Winter quarter

  • 生命医科学特論Ⅳ

    2017.12 - 2018.2   Winter quarter

  • Topics in medical life sciences Ⅳ

    2017.12 - 2018.2   Winter quarter

  • 最新トピックスから学ぶ生命科学入門Ⅲ

    2017.10 - 2017.12   Fall quarter

  • 最新トピックスから学ぶ生命科学入門Ⅱ

    2017.6 - 2017.8   Summer quarter

  • 最新トピックから学ぶ生命科学入門I

    2017.4 - 2017.9   First semester

  • 生命医科学特別講義

    2017.4 - 2017.9   First semester

  • 生命医科学特別講義

    2017.4 - 2017.9   First semester

  • 最新トピックスから学ぶ生命科学入門Ⅰ

    2017.4 - 2017.6   Spring quarter

  • 最新トピックから学ぶ生命科学入門II

    2016.10 - 2017.3   Second semester

  • 最新トピックから学ぶ生命科学入門I

    2016.4 - 2016.9   First semester

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Media Coverage

  • 九大と東大、インスリンの血中濃度変化が肝臓内の分子を個別に制御していることを発見 Newspaper, magazine

    日本経済新聞  2018.6

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    九大と東大、インスリンの血中濃度変化が肝臓内の分子を個別に制御していることを発見