Updated on 2024/10/08

Information

 

写真a

 
SHIMADA ATSUSHI
 
Organization
Medical Institute of Bioregulation Research Promotion Unit Associate Professor
Graduate School of Systems Life Sciences Department of Systems Life Sciences(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Title
Associate Professor
Contact information
メールアドレス
Tel
0926426797
Profile
Endocytosis and cell migration are dynamic physiological processes of eukaryotic cells accompanied by membrane and/or actin cytoskeletal remodeling. These processes are regulated by cellular signaling pathways, which link extracellular signals to corresponding morphological changes of the cell. We have been investigating the mechanisms underlying the functions exerted by these proteins with mainly X-ray crystallography and various biochemical techniques. We are currently intensively working on the development of a novel imaging/structure determination technology using electron microscopy for the visualization of membrane proteins in the lipid bilayer and its application to a variety of membrane proteins, including drug targets.

Degree

  • Ph.D

Research Interests・Research Keywords

  • Research theme:Development of a novel method for the structural analysis of membrane proteins

    Keyword:membrane protein

    Research period: 2019.7

  • Research theme:Structural and functional analyses of phagocytosis-related proteins

    Keyword:Phagocytosis, GAS7, F-BAR domain

    Research period: 2014.8

  • Research theme:Crystallography of the complex between a novel plant actin-binding domain and actin

    Keyword:plant, actin, FH2 domain

    Research period: 2012.7

  • Research theme:Structural biology of oligosaccharyltransferases

    Keyword:oligosaccharyltransferase, N-glycosylation

    Research period: 2011.10

  • Research theme:Structural basis of vesicle formation in endocytosis

    Keyword:X-ray crystallography, endocytosis, BAR domain, EFC/F-BAR domain

    Research period: 2004.7

Awards

  • 令和5年度 九州大学共同研究等活動表彰

    2023.11   九州大学   九州大学共同研究等活動表彰

Papers

  • CHLOROPLAST UNUSUAL POSITIONING 1 is a plant-specific actin polymerization factor regulating chloroplast movement Reviewed International journal

    Sam-Geun Kong, Yosuke Yamazaki, Atsushi Shimada, Saku T Kijima, Keiko Hirose, Kaoru Katoh, Jeongsu Ahn, Hyun-Geun Song, Jae-Woo Han, Takeshi Higa, Akira Takano, Yuki Nakamura, Noriyuki Suetsugu, Daisuke Kohda, Taro Q P Uyeda, Masamitsu Wada

    The Plant Cell   36 ( 4 )   1159 - 1181   2024.3   ISSN:1040-4651 eISSN:1532-298X

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/plcell/koad320

    Web of Science

    Scopus

    PubMed

  • Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7 Reviewed International journal

    Hanawa-Suetsugu K, Itoh Y, Ab Fatah M, Nishimura T, Takemura K, Takeshita K, Kubota S, Miyazaki N, Wan Mohamad Noor WNI, Inaba T, Nguyen NTH, Hamada-Nakahara S, Oono-Yakura K, Tachikawa M, Iwasaki K, Kohda D, Yamamoto M, Kitao A, Shimada A, Suetsugu S.

    Nature Communications   10   4763   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-12738-w

    Repository Public URL: https://hdl.handle.net/2324/7181997

  • Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain. Reviewed International journal

    29 ( 6 )   19565   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation

    Shunsuke Matsumoto, Atsushi Shimada, James Nyirenda, Mayumi Igura, Yoshiaki Kawano, Daisuke Kohda

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   110 ( 44 )   2013.10

     More details

    Language:Japanese  

    DOI: 10.1073/pnas.1309777110

  • Mapping of the basic amino-acid residues responsible for tabulation and cellular protrusion by EFC/F-BAR domain of pacsin2/Syndapin II Reviewed International journal

    Shimada, A., Takano, K., Shirouzu, M., Hanawa-Suetsugu, K., Terada, T., Toyooka, K., Umehara, T., Yamamoto, M., Yokoyama, S. and Suetsugu, S.

    FEBS Lett.   584 ( 6 )   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Curved EFC/F-BAR domain dimers are joined end to end into a filament for membrane invagination in endocytosis Reviewed International journal

    Shimada, A., Niwa, H., Tsujita, K., Suetsugu, S., Nitta, K., Hanawa-Suetsugu, K., Akasaka, R., Nishino, Y., Toyama, M., Chen, L., Liu, Z.J., Wang, B.C., Yamamoto, M., Terada, T., Miyazawa, A., Tanaka, A., Sugano, S., Shirouzu, M., Nagayama, K., Takenawa, T. and Yokoyama, S.

    Cell   129 ( 4 )   2007.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization Reviewed International journal

    Shimada, A., Nyitrai, M., Vetter, I.R., Kuhlmann, D., Bugyi, B., Narumiya, S., Geeves, M.A. and Wittinghofer, A.

    Mol. Cell   13 ( 4 )   2004.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase Reviewed International journal

    Shimada, A., Nureki, O., Goto, M., Takahashi, S. and Yokoyama S

    Proc. Natl. Acad. Sci. USA   98 ( 24 )   2001.11

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Structural basis for anticodon recognition by discriminating glutamyl-tRNA synthetase Reviewed International journal

    Sekine, S., Nureki, O., Shimada, A., Vassylyev, D.G. and Yokoyama S

    Nat. Struct. Biol.   8 ( 3 )   2001.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase Reviewed International journal

    Fukai, S., Nureki, O., Sekine, S., Shimada, A., Tao, J., Vassylyev, D.G. and Yokoyama, S.

    Cell   103 ( 5 )   2000.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Enzyme structure with two catalytic sites for double-sieve selection of substrate Reviewed International journal

    Nureki, O., Vassylyev, D.G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Hendrickson, T.L., Schimmel, P. and Yokoyama, S.

    Science   280 ( 5363 )   1998.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Effects of targeting signal mutations in a mitochondrial presequence on the spatial distribution of the conformational ensemble in the binding site of Tom20. Reviewed International journal

    Xiling Han, Nobuo Maita, Atsushi Shimada, Daisuke Kohda

    Protein Science   2022.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Ca<SUP>2+</SUP>-induced structural changes and intramolecular interactions in N-terminal region of diacylglycerol kinase alpha

    Takahashi, D; Yonezawa, K; Okizaki, Y; Caaveiro, JMM; Ueda, T; Shimada, A; Sakane, F; Shimizu, N

    PROTEIN SCIENCE   31 ( 7 )   e4365   2022.7   ISSN:0961-8368 eISSN:1469-896X

     More details

    Language:English   Publisher:Protein Science  

    Diacylglycerol kinases (DGKs) are multi-domain lipid kinases that modulate the levels of lipid messengers, diacylglycerol, and phosphatidic acid. Recently, increasing attention has been paid to its α isozyme (DGKα) as a potential target for cancer immunotherapy. However, little progress has been made on the structural biology of DGKs, and a detailed understanding of the Ca2+-triggered activation of DGKα, for which the N-terminal domains likely play a critical role, remains unclear. We have recently shown that Ca2+ binding to DGKα-EF induces conformational changes from a protease-susceptible “open” conformation in the apo state to a well-folded one in its holo state. Here, we further studied the structural properties of DGKα N-terminal (RVH and EF) domains using a series of biophysical techniques. We first revealed that the N-terminal RVH domain is a novel Ca2+-binding domain, but the Ca2+-induced conformational changes mainly occur in the EF domain. This was corroborated by NMR experiments showing that the EF domain adopts a molten-globule like structure in the apo state. Further analyses using SEC-SAXS and NMR indicate that the partially unfolded EF domain interacts with RVH domain, likely via hydrophobic interactions in the absence of Ca2+, and this interaction is modified in the presence of Ca2+. Taken together, these results present novel insights into the structural rearrangement of DGKα N-terminal domains upon binding to Ca2+, which is essential for the activation of the enzyme.

    DOI: 10.1002/pro.4365

    Web of Science

    Scopus

    PubMed

  • Ca2+-induced structural changes and intramolecular interactions in N-terminal region of diacylglycerol kinase alpha Reviewed International journal

    Takahashi D., Yonezawa K., Okizaki Y., Caaveiro J.M.M., Ueda T., Shimada A., Sakane F., Shimizu N.

    Protein Science   31   e4365   2022.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Crystal contact-free conformation of an intrinsically flexible loop in protein crystal Tim21 as the case study Reviewed

    Siqin Bala, Shoko Shinya, Arpita Srivastava, Marie Ishikawa, Atsushi Shimada, Naohiro Kobayashi, Chojiro Kojima, Florence Tama, Osamu Miyashita, Daisuke Kohda

    Biochimica et Biophysica Acta - General Subjects   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbagen.2019.129418

  • Tethering an N-Glycosylation Sequon-Containing Peptide Creates a Catalytically Competent Oligosaccharyltransferase Complex. Reviewed International journal

    Shunsuke Matsumoto, Yuya Taguchi, Atsushi Shimada, Mayumi Igura, Daisuke Kohda

    56 ( 4 )   602 - 611   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.biochem.6b01089

  • Rational design of crystal contact-free space in protein crystals for analyzing spatial distribution of motions within protein molecules. Reviewed International journal

    Rei Matsuoka, Atsushi Shimada, Yasuaki Komuro, Yuji Sugita, Daisuke Kohda

    Protein Sci.   25 ( 3 )   754 - 768   2016.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2 Reviewed International journal

    Nobuaki Takahashi, Sayaka Hamada-Nakahara, Yuzuru Itoh, Kazuhiro Takemura, Atsushi Shimada, Yoshifumi Ueda, Manabu Kitamata, Rei Matsuoka, Kyoko Hanawa-Suetsugu, Yosuke Senju, Masayuki X. Mori, Shigeki Kiyonaka, Daisuke Kohda, Akio Kitao, Yasuo Mori, Shiro Suetsugu

    Nature Communications   5   Article number: 4994   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms5994

  • Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases Reviewed International journal

    Shunsuke Matsumoto, Atsushi Shimada, Daisuke Kohda

    BMC STRUCTURAL BIOLOGY   13   2013.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1472-6807-13-11

  • Actin filament bundling and different nucleating effects of mouse Diaphanous-related formin FH2 domains on Actin/ADF and Actin/Cofilin complexes Reviewed International journal

    Machaidze, G., Sokoll, A., Shimada, A., Lustig, A., Mazur, A., Wittinghofer, A., Aebi, U. and Mannherz, H.G.

    J. Mol. Biol.   403 ( 4 )   2010.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S.Pombe Reviewed International journal

    Hirose, E., Mukai, M., Shimada, A., Nishitani, H., Shibata, Y. and Nishimoto, T.

    Genes Cells   11 ( 1 )   2006.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase Reviewed International journal

    Fukai, S., Nureki, O., Sekine, S., Shimada, A., Vassylyev, D.G. and Yokoyama, S.

    RNA   9 ( 1 )   2003.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Crucial role of the HIGH-loop lysine for the catalytic activity of arginyl-tRNA synthetase Reviewed International journal

    Sekine, S., Shimada, A., Nureki, O., Cavarelli, J., Moras, D., Vassylyev, D.G. and Yokoyama, S.

    J. Biol. Chem.   276 ( 6 )   2001.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Gene cloning, expression, crystallization and preliminary X-ray analysis of Thermus thermophilus arginyl-tRNA synthetase Reviewed International journal

    Shimada, A., Nureki, O., Dohmae, N., Takio, K. and Yokoyama, S.

    Acta Crystallogr. D Biol. Crystallogr.   57 (Pt2)   2001.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The 2.0 Å crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules Reviewed International journal

    8 ( 2 )   2000.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Presentations

  • 脂質二重膜中での高次タンパク質集合のイメージング Invited

    嶋田 睦

    第95回日本生化学会大会  2022.11 

     More details

    Event date: 2022.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • クラスリン依存性エンドサイトーシスにおけるクラスリン重合調節機構の構造的基盤

    山口 淳子、嶋田 睦

    第41回日本分子生物学会年会  2018.11 

     More details

    Event date: 2018.11

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • エンドサイトーシス関連細胞質タンパク質の構造から迫るクラスリン重合機構 (Insights into clathrin assembly from the structures of cytosolic endocytic proteins) Invited

    嶋田 睦

    第55回 日本生物物理学会年会  2017.9 

     More details

    Event date: 2017.9

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本大学 黒髪地区   Country:Japan  

  • SGIP1 μ homology ドメインへの結合における連続するDPFモチーフ数の増加による親和性向上機構

    嶋田 睦, 山口 淳子, 神田 大輔

    第39回日本分子生物学会年会  2016.12 

     More details

    Event date: 2016.11 - 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain and its implications for the mechanism of affinity enhancement by the increase in the number of consecutive DPF motifs International conference

    嶋田 睦, 山口 淳子, 神田 大輔

    The 42nd Naito Conference, “In the Vanguard of Structural Biology: Revolutionizing Life Sciences”  2016.10 

     More details

    Event date: 2016.10

    Language:English  

    Venue:Sapporo   Country:Japan  

  • クラスリン依存性エンドサイトーシスにおけるタンパク質-タンパク質相互作用 Invited

    嶋田 睦, 山口 淳子, 神田 大輔

    第15回日本蛋白質科学会年会  2015.6 

     More details

    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:あわぎんホール (徳島県・徳島市)   Country:Japan  

  • SGIP1 μ homology domainによるEps15認識機構の構造的基盤

    山口 淳子, 神田 大輔, 嶋田 睦

    平成26年度日本生化学会九州支部例会  2014.5 

     More details

    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:九州大学病院キャンパスコラボステーションI (福岡)   Country:Japan  

  • Structural basis for the recognition of tandem DPF motifs by the SGIP1 μ homology domain International conference

    2014.2 

     More details

    Event date: 2014.2

    Language:English  

    Venue:Melbourne   Country:Australia  

  • Cdc42によるCIP4ファミリータンパク質のクラスリン被覆ピットへの局在機構の構造的基盤 Invited

    嶋田 睦, 末次 志郎, 松永 笑子, 外山 光俊, 寺田 貴帆, 白水 美香子, 竹縄 忠臣, 山本 雅貴, 横山 茂之

    第35回日本分子生物学会年会  2012.12 

     More details

    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 脂質二重膜中の膜タンパク質の迅速高分解能イメージングパイプライン Invited

    湯通堂 紀子,嶋田 睦

    第11回TR推進合同フォーラム・ライフサイエンス技術交流会  2024.1 

     More details

    Event date: 2024.1

    Language:Japanese  

    Venue:九州大学 医学部百年講堂   Country:Japan  

  • Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study

    #Siqin Bala, @Shoko Shinya, @Arpita Srivastava, #Marie Ishikawa, Atsushi Shimada, @Naohiro Kobayashi, @Chojiro Kojima, @Florence Tama, @Osamu Miyashita, Daisuke Kohda

    2019.12 

     More details

    Event date: 2019.12

    Language:English  

    Country:Japan  

  • DGKα活性制御の分子基盤: N末端RVH領域へのCa2+結合の物理化学的解析

    高橋大輔, 嶋田睦, Jose Caarveiro, 阿部義人, 植田正, @坂根郁夫

    2019年度日本生化学会九州支部例会  2019.6 

     More details

    Event date: 2019.6

    Language:Japanese  

    Venue:長崎大学 (長崎市)   Country:Japan  

  • Mechanistic models of endocytosis based on the structural studies on endocytic proteins Invited International conference

    Atsushi Shimada

    Scientific Seminar  2018.7 

     More details

    Event date: 2018.7

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Spain  

  • 短い繰り返しモチーフであるDPFモチーフの繰り返し数の増加によるSGIP1 μ homology domainへの親和性向上機構

    嶋田 睦, 山口 淳子, 神田 大輔

    第16回日本蛋白質科学会年会  2016.6 

     More details

    Event date: 2016.6

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • SGIP1 μ homologyドメインによる2つの連続するDPF配列認識機構の構造的基盤

    山口 淳子, 神田 大輔, 嶋田 睦

    第87回日本生化学会大会  2014.10 

     More details

    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立京都国際会館・グランドプリンスホテル京都 (京都府・京都市)   Country:Japan  

  • Structural basis for the recognition of Eps15 by the SGIP1 μ homology domain International conference

    2014.8 

     More details

    Event date: 2014.8

    Language:English  

    Venue:Montreal   Country:Canada  

  • SGIP1 μ homologyドメインによるEps15認識機構の構造的基盤

    山口 淳子, 神田 大輔, 嶋田 睦

    第14回日本蛋白質科学会年会  2014.6 

     More details

    Event date: 2014.6

    Language:Japanese  

    Venue:ワークピア横浜/横浜産貿ホール マリネリア (神奈川県・横浜市)   Country:Japan  

  • 植物の新規アクチン結合ドメインとアクチンの複合体の結晶構造解析 Invited

    嶋田 睦

    新学術領域研究「構造細胞生物学」第4回全体会議  2013.6 

     More details

    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山梨   Country:Japan  

  • Cdc42による CIP4のクラスリン被覆ピットへの局在機構の構造的基盤

    嶋田 睦, 末次 志郎, 松永 笑子, 外山 光俊, 寺田 貴帆, 白水 美香子, 竹縄 忠臣, 山本 雅貴, 横山 茂之

    第12回日本蛋白質科学会年会  2012.6 

     More details

    Event date: 2012.6

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • Structural basis of Cdc42-mediated Cdc42-interacting protein 4 (CIP4) recruitment to clathrin-coated pits International conference

    Atsushi Shimada

    The 21st Hot Spring Harbor Symposium jointly with 9th Global-COE International Symposium Cell Migration in Biology and Medicine -8th Young Investigators Forum-  2012.1 

     More details

    Event date: 2012.1

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Structural basis of Cdc42-mediated Cdc42-interacting protein 4 (CIP4) recruitment to clathrin-coated pits International conference

    Atsushi Shimada

    10th Global-COE International Symposium and 7th Young Investigators Forum  2011.12 

     More details

    Event date: 2011.12

    Presentation type:Symposium, workshop panel (public)  

    Country:Singapore  

  • Cdc42によるCdc42-interacting protein 4 (CIP4) のクラスリン被覆ピットへの局在機構の構造的基盤

    嶋田 睦

    日本生物物理学会九州支部例会  2011.12 

     More details

    Event date: 2011.12

    Venue:福岡県飯塚市のがみプレジデントホテル   Country:Japan  

  • 動的な細胞内プロセスにおける膜タンパク質研究の新機軸 脂質二重膜中での高次タンパク質集合のイメージング

    嶋田 睦

    日本生化学会大会プログラム・講演要旨集  2022.11  (公社)日本生化学会

     More details

    Language:English  

▼display all

MISC

  • Crystal structure of the EFC/F-BAR domain -mechanism of membrane invagination in endocytosis-

    Atsushi Shimada and Shigeyuki Yokoyama

    SPring-8 Research Frontiers 2007   2008.7

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • EFC/F-BARドメインの構造機能解析 ―エンドサイトーシスにおける細胞膜陥入機構―

    嶋田 睦,末次 志郎,白水 美香子,永山 國昭,横山 茂之

    日本結晶学会誌   2008.4

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • EFC/F-BARドメインによる細胞膜陥入機構

    嶋田 睦,丹羽 英明,白水 美香子,辻田 和也,末次 志郎,竹縄 忠臣,新田 浩二,永山 國昭,横山 茂之

    実験医学   2007.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 低分子量Gタンパク質を介したシグナル伝達に関わるタンパク質の構造と機能

    白水 美香子,村山 和隆,新野-柊本 睦子, 嶋田 睦,横山 茂之

    実験医学   2006.11

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 新規アクチン重合促進タンパク質mDiaの構造と生化学的機能―細胞生物学が生化学と構造生物学に出会うとき

    嶋田 睦

    実験医学   2004.10

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 連続フェムト秒結晶構造解析により解明されたアンジオテンシン受容体の構造

    嶋田 睦

    秀潤社、細胞工学別冊、最新バイオ論文総集編1   2015.9

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Structural basis for amino acid and tRNA recognition by class I aminoacyl-tRNA synthetases

    Nureki, O., Fukai, S., Sekine, S., Shimada, A., Terada, T., Nakama, T., Shirouzu, M., Vassylyev, D.G. and Yokoyama, S.

    Cold Spring Harb. Symp. Quant. Biol.   2001.1

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Industrial property rights

Patent   Number of applications: 6   Number of registrations: 3
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Biophysical Society of Japan

  • The Molecular Biology Society of Japan

  • Protein Science Society of Japan

  • Japanese Biochemical Society

Academic Activities

  • ポスターディスカッサー

    第42回日本分子生物学会年会  ( 福岡 ) 2019.12

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

  • ポスターディスカッサー

    第41回日本分子生物学会年会  ( 横浜 ) 2018.11

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • 司会進行

    第15回 糖鎖科学コンソーシアムシンポジウム  ( 福岡 ) 2017.10

     More details

    Type:Competition, symposium, etc. 

  • シンポジウムオーガナイザーと座長

    第55回 日本生物物理学会年会  ( 熊本大学 黒髪地区 ) 2017.9

     More details

    Type:Competition, symposium, etc. 

  • 実行委員

    第55回日本生物物理学会年会  ( 熊本 ) 2017.9

     More details

    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第39回日本分子生物学会年会  ( 横浜 ) 2016.11 - 2016.7

     More details

    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第19回 九州大学 生体防御医学研究所リトリート2016  ( 熊本 ) 2016.7

     More details

    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第16回日本蛋白質科学会年会  ( 福岡 ) 2016.6

     More details

    Type:Competition, symposium, etc. 

  • 司会(Moderator) International contribution

    2015.11

     More details

    Type:Competition, symposium, etc. 

  • 学術調査官

    Role(s): Review, evaluation

    文部科学省  2014.8 - 2016.7

     More details

    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第17回 生体防御医学研究所リトリート2014  ( ホテルセキヤ,熊本 ) 2014.7

     More details

    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    平成26年度日本生化学会九州支部例会  ( 九州大学病院キャンパスコラボステーションI (福岡) ) 2014.5

     More details

    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第16回 生体防御医学研究所リトリート2013,第7回 理医連携リトリート  ( 熊本 ) 2013.8

     More details

    Type:Competition, symposium, etc. 

▼display all

Research Projects

  • 令和 6 年度 橋渡し研究プログラム シーズ H 「創薬を革新する新規の膜タンパク質高分解能イメー ジング技術の汎用化」

    2024.4

      More details

    Authorship:Principal investigator 

  • 創薬を革新する新規の膜タンパク質高分解能イメー ジング技術の汎用化

    2024

    令和 6 年度 橋渡し研究プログラム シーズ H

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 大学発ベンチャー事業シーズ育成支援プログラム (九大ステップファンド)「創薬を革新する新規の膜タンパク質構造解析技術の高度化」

    2023.9 - 2025.3

      More details

    Authorship:Principal investigator 

  • 令和 5 年度 橋渡し研究プログラム シーズ H 「創薬を革新する新規の膜タンパク質構造解析技術の汎用化」

    2023.4 - 2024.3

      More details

    Authorship:Principal investigator 

  • 創薬を革新する新規の膜タンパク質構造解析技術の高度化

    2023 - 2024

    大学発ベンチャー事業シーズ育成支援プログラム (九大ステップファンド)

      More details

    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 創薬を革新する新規の膜タンパク質構造解析技術の汎用化

    2023

    令和5年度 橋渡し研究プログラム シーズH

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • JST大学発新産業創出プログラム (START) 大学・エコシステム推進型 PARKS起業活動支援プログラム GAP・NEXT 「創薬を革新する新規の膜タンパク質構造解析技術」

    2022.9 - 2023.3

      More details

    Authorship:Principal investigator 

  • 創薬を革新する新規の膜タンパク質構造解析技術

    2022

    大学発ベンチャー創出推進のための事業 (文部科学省)

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • Development of a novel method for the structural analysis of membrane proteins

    Grant number:21K06033  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • 令和3年度 九州・大学発ベンチャー振興会議研究助成金/新規膜タンパク質構造解析技術の開発とその創薬展開

    2021

      More details

    Grant type:Donation

  • 大学発ベンチャー事業シーズ育成支援プログラム「生体高分子の立体構造解析のための革新的試料調製法の産業利用」

    2020.4 - 2020.11

      More details

    Authorship:Principal investigator 

  • 生体高分子の立体構造解析のための革新的試料調製法の産業利用

    2020

    大学発ベンチャー事業シーズ育成支援プログラム (九大ギャップファンド)

      More details

    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • クラスリン依存性エンドサイトーシスにおけるクラスリン重合進行機構の構造的基盤

    Grant number:17K07309  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 植物の新規アクチン結合ドメインとアクチンの複合体の結晶構造解析

    Grant number:25121726  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 九州大学P&P D2タイプ 「膜輸送および小胞体‐ミトコンドリア間相互作用に関与するタンパク質ファミリーの構造機能解析」

    2012.4 - 2013.3

    九州大学(日本) 

      More details

    Authorship:Principal investigator 

    小胞体-ゴルジ体間、ゴルジ体-エンドソーム間など多岐にわたる内膜間の輸送経路や、小胞体-ミトコンドリア間相互作用に関与するタンパク質ファミリーの構造機能解析を行う。

  • 細胞のがん化に関与するエンドサイトーシス機構の構造的基盤

    Grant number:24687014  2012 - 2014

    科学研究費助成事業  若手研究(A)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 膜輸送および小胞体‐ミトコンドリア間相互作用に関与するタンパク質ファミリーの構造機能解析

    2012

    九州大学P&P D2タイプ

      More details

    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • エンドサイトーシスにおける小胞形成機構の構造的基盤

    Grant number:20687006  2008 - 2011

    科学研究費助成事業  若手研究(A)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Class subject

  • 最新トピックスから学ぶ生命科学入門

    2024.12 - 2025.2   Winter quarter

  • 生命医科学特論I

    2024.6 - 2024.8   Summer quarter

  • 最新トピックスから学ぶ生命科学入門

    2023.12 - 2024.2   Winter quarter

  • 生命医科学特論I

    2023.6 - 2023.8   Summer quarter

  • 最新トピックスから学ぶ生命科学入門

    2022.12 - 2023.2   Winter quarter

  • 生命医科学特論III

    2022.6 - 2022.8   Summer quarter

  • 最新トピックスから学ぶ生命科学入門

    2021.12 - 2022.2   Winter quarter

  • 生命医科学特論Ⅲ

    2021.6 - 2021.8   Summer quarter

  • 生命医科学特論III

    2020.6 - 2020.8   Summer quarter

  • 生命医科学特別研究

    2020.4 - 2021.3   Full year

  • 構造生命科学講究

    2020.4 - 2021.3   Full year

  • 学際開拓創成セミナーI

    2019.10 - 2020.3   Second semester

  • 生命医科学特論III

    2019.6 - 2019.8   Summer quarter

  • 生命医科学特別研究

    2019.4 - 2020.3   Full year

  • 構造生命科学講究

    2019.4 - 2020.3   Full year

  • 最新トピックスから学ぶ生命科学入門Ⅱ

    2018.12 - 2019.2   Winter quarter

  • 生命医科学特論III

    2018.6 - 2018.8   Summer quarter

  • 生命医科学特別研究

    2018.4 - 2019.3   Full year

  • 構造生命科学講究

    2018.4 - 2019.3   Full year

  • 生命医科学特論III

    2017.10 - 2017.12   Fall quarter

  • 生命医科学特別研究

    2017.4 - 2018.3   Full year

  • 構造生命科学講究

    2017.4 - 2018.3   Full year

  • 最新トピックスから学ぶ生命科学入門I

    2017.4 - 2017.6   Spring quarter

  • 構造生物学特論

    2016.10 - 2017.3   Second semester

  • 生命医科学特別研究

    2016.4 - 2017.3   Full year

  • 構造生命科学講究

    2016.4 - 2017.3   Full year

  • 最新トピックスから学ぶ生命科学入門I

    2016.4 - 2016.9   First semester

  • 学際開拓創成セミナーI

    2015.10 - 2016.3   Second semester

  • 学際開拓創成セミナーII

    2015.10 - 2016.3   Second semester

  • 生命医科学特別研究

    2015.4 - 2016.3   Full year

  • 構造生命科学講究

    2015.4 - 2016.3   Full year

  • 構造生物学特論

    2014.10 - 2015.3   Second semester

  • 生命医科学特別研究

    2014.4 - 2015.3   Full year

  • ゲノム生体高分子学講究

    2014.4 - 2015.3   Full year

  • 学際開拓創成セミナーI

    2013.10 - 2014.3   Second semester

  • 博士論文指導演習

    2013.4 - 2014.3   Full year

  • 生命医科学特別研究

    2013.4 - 2014.3   Full year

  • ゲノム生体高分子学講究

    2013.4 - 2014.3   Full year

  • 学際開拓創成セミナーII

    2013.4 - 2013.9   First semester

  • 学際開拓創成セミナーI

    2012.10 - 2013.3   Second semester

  • 構造生物学特論

    2012.10 - 2013.3   Second semester

  • 博士論文指導演習

    2012.4 - 2013.3   Full year

  • 生命医科学特別研究

    2012.4 - 2013.3   Full year

  • ゲノム生体高分子学講究

    2012.4 - 2013.3   Full year

▼display all

FD Participation

  • 2024.4   Role:Participation   Title:生体防御医学研究所FD(法務コンプライアンス関連FD)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.2   Role:Participation   Title:令和3年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.11   Role:Participation   Title:令和2年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.9   Role:Participation   Title:M2B学習支援システム講習会

    Organizer:University-wide

  • 2019.12   Role:Participation   Title:令和元年度 九州大学大学院医学系学府教育FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.10   Role:Participation   Title:令和元年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.2   Role:Participation   Title:生体防御医学研究所FD(情報セキュリティ関連FD)

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.11   Role:Participation   Title:2018年度 生体防御医学研究所 研究・教育FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.10   Role:Participation   Title:平成30年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2017.10   Role:Participation   Title:平成29年度 男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2017.5   Role:Participation   Title:電子教材著作権講習会

    Organizer:University-wide

  • 2016.10   Role:Participation   Title:馬出地区キャンパス FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.4   Role:Participation   Title:平成24年度第1回全学FD(新任教員の研修)

    Organizer:University-wide

▼display all

Social Activities

  • 創薬を革新する新規の膜タンパク質構造解析技術

    JST大学発新産業創出プログラム(START)PARKS DemoDay 2023  TKPガーデンシティPREMIUM 天神スカイホール (福岡市)  2023.3

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 九州大学ベンチャーエコシステム連絡会2020年度第3回

    九州大学  web講演  2020.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Media Coverage

  • 免疫細胞の異物取り込み解明 Newspaper, magazine

    日経産業新聞  2019.10

     More details

    免疫細胞の異物取り込み解明

  • マクロファージの異物消化時に形成 食作用カップの機構解明 Newspaper, magazine

    科学新聞  2019.10

     More details

    マクロファージの異物消化時に形成
    食作用カップの機構解明

  • 細胞の物質摂取仕組みを解明 弓状のタンパク質巻き付き膜絞り込む Newspaper, magazine

    山陽新聞  2007.7

     More details

    細胞の物質摂取仕組みを解明 弓状のタンパク質巻き付き膜絞り込む

  • 細胞に物質取り込む仕組み タンパク質が一役 Newspaper, magazine

    福井新聞  2007.7

     More details

    細胞に物質取り込む仕組み タンパク質が一役

  • 物質を内側に取り込み 細胞膜陥入を解明 「脂質膜の筒状化」実証 Newspaper, magazine

    科学新聞  2007.6

     More details

    物質を内側に取り込み 細胞膜陥入を解明 「脂質膜の筒状化」実証

  • 理化学研究所など、細胞外から細胞内へ分子を取り込む細胞膜陥入機構を解明 Newspaper, magazine

    日経産業新聞  2007.5

     More details

    理化学研究所など、細胞外から細胞内へ分子を取り込む細胞膜陥入機構を解明

  • 細胞による外部分子取り込み 機能タンパク質を解明 Newspaper, magazine

    日刊工業新聞  2007.5

     More details

    細胞による外部分子取り込み 機能タンパク質を解明

▼display all

Travel Abroad

  • 2018.6 - 2018.7

    Staying countory name 1:Germany   Staying institution name 1:Max Planck Institute of Molecular Physiology

    Staying countory name 2:Spain   Staying institution name 2:Max-Delbrück-Centrum for Molecular Medicine

    Staying institution name 3:CIC bioGUNE

  • 2014.8

    Staying countory name 1:Canada   Staying institution name 1:IUCr 2014 (Palais des congrès, Montreal)

  • 2014.2

    Staying countory name 1:Australia   Staying institution name 1:Monash University

  • 2011.12

    Staying countory name 1:Singapore   Staying institution name 1:National University of Singapore

  • 2004.1 - 2004.6

    Staying countory name 1:Germany   Staying institution name 1:Max Planck Institute of Molecular Physiology

  • 2001.6 - 2003.9

    Staying countory name 1:Germany   Staying institution name 1:Max Planck Institute of Molecular Physiology

▼display all