Updated on 2024/10/01

Information

 

写真a

 
SHIBATA HIROKI
 
Organization
Medical Institute of Bioregulation Research Promotion Unit Associate Professor
Abolition organization Research Center for Transomics Medicine(Joint Appointment)
Graduate School of Systems Life Sciences Department of Systems Life Sciences(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
School of Sciences Department of Biology(Joint Appointment)
School of Dentistry Department of Dentistry(Joint Appointment)
Title
Associate Professor
Tel
0926426168
Profile
Two major research projects (both heavily using NGS) are ongoing: 1. Exome sequencing is a powerful technique to identify causative variants of genetic diseases (Figure). However, the filtration of numerous candidate variants can be very difficult especially diseases so rare that a single pedigree ascertained. We introduced SNP linkage information for the filtration (Linkage-assisted exome sequencing). We are currently applying the technique on the analyses of multiple hereditary neurological diseases, such as idiopathic hyper CK-emia, spastic paraplegia and familial myochronic epilepsy. 2. Venoms are promising seeds for pharmaceutical discovery. Japanese pit viper, Habu snake (Protobothrops flavoviridis) is well known for the dangerous bites. However most of the venomic proteins are uncharacterized. Also accelerated evolution has been reported in many of the venomic proteins. Towards the complete characterization of the venomic proteins and the understanding of the mechanism of their accelerated evolution, we are currently working on omics studies of Habu snake, including whole genome sequencing, RNA-sequencing and population genetics studies. We are also participating in international research projects of whole genome sequencing of Elapidae (cobras).
Homepage
External link

Degree

  • Ph D.

Research History

  • Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, LA 5/1/96-4/30/99

Research Interests・Research Keywords

  • Research theme:Ddhd1 KO mouse as a model of spastic paraplegia

    Keyword:spastic paraplegia, Ddhd1, CRISPR, RNA-seq, metabolome analysis

    Research period: 2015.4

  • Research theme:Genetic analysis of spastic paraplegia

    Keyword:spinocerebellar ataxia, linkage analysis, next generation sequencer, exome sequencing

    Research period: 2014.4

  • Research theme:Genetic analysis of spinocerebellar ataxia

    Keyword:spinocerebellar ataxia, linkage analysis, next generation sequencer, exome sequencing

    Research period: 2014.4

  • Research theme:Genetic divergence and diversity of venom proteins among island populations of Japanese Habu snakes, Protobothrops.

    Keyword:Protobothrops flavoviridis, Protobothrops tokarensis, Protopbothrops elegans, venom protein gene, genetic divergence, genetic diversity,

    Research period: 2012.4

  • Research theme:Whole genome sequencing of Japanese Habu viper, Protobothrops flavoviridis.

    Keyword:Protobothrops flavoviridis, next generation sequencer, denovo assembly, scaffolding, gene prediction, snake venoms

    Research period: 2012.4

  • Research theme:Divergence and diversity of mitogenome among island populations of Japanese Habu snakes, Protobothrops.

    Keyword:Protobothrops flavoviridis, Protobothrops tokarensis, Protopbothrops elegans, mitochondria genome, microsatellite marker, genetic divergence, genetic diversity,

    Research period: 2012.4

  • Research theme:Construction of the full length gene catalogue of Japanese Habu viper, Protobothrops flavoviridis.

    Keyword:Protobothrops flavoviridis, next generation sequencer, RNA-sequencing, cDNA, venom gland, snake venoms

    Research period: 2011.9

  • Research theme:Genetic analysis of familial myoclonic epilepsy

    Keyword:familial myoclonic epilepsy, linkage analysis, next generation sequencer, exome sequencing

    Research period: 2011.4

  • Research theme:Exome sequencing approach to identify the responsible variant for a hereditary motor and sensory neuropathy

    Keyword:Hereditary motor and sensory neuropathy, linkage analysis, next generation sequencer, exome sequencing

    Research period: 2010.4

  • Research theme:Evolutionary study of schizophrenia-associated genes.

    Keyword:schizophrenia, glutamate receptor, molecular evolution, genetic diversity, natural selection

    Research period: 2004.4 - 2013.3

  • Research theme:向精神薬応答遺伝子群のマイクロアレイによる解析

    Keyword:PCP マイクロアレイ

    Research period: 2003.4

  • Research theme:脊髄小脳失調症16型の原因遺伝子探索

    Keyword:SCA16、小脳、運動失調、全ゲノムスキャン

    Research period: 2002.4 - 2006.3

  • Research theme:統合失調症の全ゲノム関連解析

    Keyword:統合失調症 マイクロサテライトマーカー DNAプール法 関連解析

    Research period: 2002.4

  • Research theme:家族性筋萎縮性側索硬化症の新規な原因遺伝子の単離

    Keyword:筋萎縮性側索硬化症 連鎖解析 マイクロサテライトマーカー

    Research period: 2001.4

  • Research theme:統合失調症の全ゲノム罹患同胞対解析

    Keyword:統合失調症 ノンパラメトリック連鎖解析 罹患同胞対 マイクロサテライトマーカー

    Research period: 1999.5 - 2004.1

  • Research theme:統合失調症とグルタミン酸受容体遺伝子群の関連解析

    Keyword:統合失調症 関連解析 SNP 連鎖不平衡 ハプロタイプ グルタミン酸受容体

    Research period: 1999.5

Papers

  • Active expression of genes for protein modification enzymes in the venom gland of habu snakes Reviewed International journal

    #Akiko Isomoto, Eiichi Shoguchi, Kanako Hisata, Jun Inoue, #Yinrui Sun, Kenji Inaba, Noriyuki Satoh, Tomohisa Ogawa, Hiroki Shibata

    Toxins (Basel)   14   300   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Familial paroxysmal kinesigenic dyskinesia with a novel missense variant (Arg2866Trp) in NBEA. Reviewed International journal

    Shiroh Miura, #Tomofumi Shimojo, #Takuya Morikawa, Takashi Kamada, Yusuke Uchiyama, Seiji Kurata, Ryuta Fujioka, Hiroki Shibata

    J Hum Genet.   66 ( 8 )   805 - 811   2021.3

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  • Ddhd1 knockout mouse as a model for familial spastic paraplegia Reviewed International journal

    #Takuya Morikawa, Hiroaki Ohishi, #Kengo Kosaka, #Tomofumi Shimojo, #Akihiro Nagano, Itsuki Taniguchi, Ryuta Fujioka, Kosei Moriyama, Motoko Unoki2#, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Hiroyuki Sasaki, Shiroh Miura, Hiroki Shibata

    Biosci Rep.   41 ( 2 )   BSR20204171   2021.2

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  • Intronic variant in IQGAP3 associated with hereditary neuropathy with proximal lower dominancy, urinary disturbance, and paroxysmal dry cough. Reviewed International journal

    Shiroh Miura, #Kengo Kosaka, #Tomofumi Shimojo, Eiji Matsuura, Kazuhito Noda, Ryuta Fujioka, Shin-Ichiro Mori, Fujio Umehara, Toru Iwaki, Ken Yamamoto, Hirotomo Saitsu, Hiroki Shibata

    J Hum Genet.   65 ( 9 )   717 - 725   2020.9

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  • Alternative mRNA splicing in three venom families underlying a possible production of divergent venom proteins of the Habu snake, Protobothrops flavoviridis. Reviewed International journal

    Tomohisa Ogawa, Naoko Oda-Ueda, Kanako Hisata, Hitomi Nakamura, Takahito Chijiwa, Shousaku Hattori, #Akiko Isomoto, #Haruki Yugeta, #Shinichi Yamasaki, Yasuyuki Fukumaki, Motonori Ohno, Noriyuki Satoh, Hiroki Shibata

    Toxins   11 ( 10 )   581 - 581   2019.10

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  • The habu genome reveals an evolutionary background of venom protein genes. Reviewed International journal

    Hiroki Shibata, Takahito Chijiwa, Naoko Oda-Ueda, Hitomi Nakamura, Kazuaki Yamaguchi, Shousaku Hattori, Kazumi Matsubara, Yoichi Matsuda, Akifumi Yamashita, #Akiko Isomoto, Kazuki Mori, Kosuke Tashiro, Satoru Kuhara, Shinichi Yamasaki, Manabu Fujie, Hiroki Goto, Ryo Koyanagi, Takeshi Takeuchi, Yasuyuki Fukumaki, Motonori Ohno, Eiichi Shoguchi, Kanako Hisata, Noriyuki Satoh, Tomohisa Ogawa

    Sci Rep.   8   11300   2018.7

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  • Facultative parthenogenesis validated by DNA analyses in the green anaconda (Eunectes murinus). Reviewed International journal

    Hiroki Shibata, Shuichi Sakata, Yuzo Hirano, Eiji Nitasaka, Ai Sakabe.

    Plos ONE   12 ( 12 )   e0189654   2017.12

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  • A novel missense variation (Q220R) of GNB4 encoding a guanine nucleotide-binding protein, beta-4 in a Japanese autosomal dominant motor and sensory neuropathy family. Reviewed International journal

    Shiroh Miura, #Takuya Morikawa, Ryuta Fujioka, Kazuhito Noda, #Kengo Kosaka, Takayuki Taniwaki, Hiroki Shibata

    Eur J Med Genet.   60 ( 9 )   474 - 478   2016.6

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  • A novel frameshift mutation of DDHD1 in a Japanese patient with autosomal recessive spastic paraplegia. Reviewed International journal

    Shiroh Miura, Takuya Morikawa, Ryuta Fujioka, Kengo Kosaka, Kohei Yamada, Kazuhito Noda, Gohsuke Hattori, Manabu Motomura, Takayuki Taniwaki, Hiroki Shibata

    Eur J Med Genet.   59 ( 8 )   413 - 416   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejmg.2016.05.010

  • The taxonomic position and the unexpected divergence of the Habu viper, Protobothrops among Japanese subtropical islands. Reviewed International journal

    Hiroki Shibata, Takahito Chijiwa, Shosaku Hattori, Koki Terada, Motonori Ohno, Yasuyuki Fukumaki

    Mol Phylogenet Evol.   101   91 - 100   2016.4

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    DOI: 10.1016/j.ympev.2016.04.027

  • A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia Reviewed International journal

    #Ken Sano, Shiroh Miura, Toshiya Fujiwara, Ryuta Fujioka, Akiko Yorita, Kazuhito Noda, Hiroshi Kida, Koichi Azuma, Shinjiro Kaieda, Ken Yamamoto, Takayuki Taniwaki, Yasuyuki Fukumaki, Hiroki Shibata

    J Neurol Sci.   356 ( 1-2 )   142 - 147   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jns.2015.06.035

  • DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. Reviewed International journal

    #Naoki Kubo, Hidehiro Toh, Kenjiro Shirane, Takayuki Shirakawa, Hisato Kobayashi, Sato Tetsuya, Hidetoshi Sone, Yasuyuki Sato, Shin-ichi Tomizawa, Yoshinori Tsurusaki, Hiroki Shibata, Hirotomo Saitsu, Yutaka Suzuki, Naomichi Matsumoto, Tomohiro Kono, Kazuyuki Ohbo, Hiroyuki Sasaki

    BMC Genomics   16 ( 1 )   624 - 624   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12864-015-1833-5

  • Genome-wide association study of schizophrenia using microsatellite markers in the Japanese population. Reviewed International journal

    Hiroki Shibata, Ken Yamamoto, #Zhu Sun, Akira Oka, Hidetoshi Inoko, Tadao Arinami, Toshiya Inada, Hiroshi Ujike, Masanari Itokawa, Mamoru Tochigi, Yuichiro Watanabe, Toshiyuki Someya, Hiroshi Kunugi, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

    Psychiatr Genet.   23 ( 3 )   117 - 123   2013.6

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  • The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family. Reviewed International journal

    Hiroki Goto, #Kazunori Watanabe, #Naozumi Araragi, #Rui Kageyama, #Kunika Tanaka, Yoko Kuroki, Atsushi Toyoda, Masahira Hattori, Yoshiyuki Sakaki, Asao Fujiyama, Yasuyuki Fukumaki, Hiroki Shibata.

    BMC Evol Biol.   9   224   2009.9

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    The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family.

    Other Link: http://www.biomedcentral.com/1471-2148/9/224

  • Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. Reviewed International journal

    Hiroki Shibata, Ayako Tani, #Tomoyuki Chikuhara, #Rumiko Kikuta, Mayumi Sakai, Hideaki Ninomiya, Nobutada Tashiro, Nakao Iwata, Norio Ozaki and Yasuyuki Fukumaki.

    Psychiatric Res.   167   88 - 96   2009.4

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  • Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. Reviewed International journal

    Hiroki Shibata, #Toshihiro Aramaki, Mayumi Sakai, Hideaki Ninomiya, Nobutada Tashiro, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

    Psychiatry Res.   141   39 - 51   2006.1

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  • Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia. Reviewed International journal

    #Chieko Makino, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki.

    Psychiatr Genet.   15 ( 3 )   215 - 221   2005.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00041444-200509000-00014

  • Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. Reviewed International journal

    #Xiangdong Deng, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

    BMC Psychiatry   4 ( 1 )   21   2004.8

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    DOI: 10.1186/1471-244X-4-21

  • Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. Reviewed International journal

    #Hiromi Takaki, #Rumiko Kikuta, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    Am J Med Genet.   128B ( 1 )   6 - 14   2004.7

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    DOI: 10.1002/ajmg.b.20108

  • Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families. Reviewed International journal

    The Japanese Schizophrenia Sib-pair Linkage Group.

    Am J Med Genet.   120B ( 1 )   22 - 28   2003.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ajmg.b.20022

  • Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Reviewed International journal

    #Yo Fujii, Hiroki Shibata, #Rumiko Kikuta, #Chieko Makino, Ayako Tani, #Naotsugu Hirata, #Atsushi Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    Psychiatric Genetics.   13 ( 2 )   71 - 76   2003.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.ypg.0000056682.82896.b0

  • Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. Reviewed International journal

    #Chieko Makino, #Yo Fujii, #Rumiko Kikuta, #Naotsugu Hirata, Ayako Tani, #Atsushi Shibata, Hideaki Ninomiya, Nobutada Tashiro, Hiroki Shibata, Yasuyuki Fukumaki

    Am J Med Genet.   116B ( 1 )   17 - 22   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ajmg.b.10041

  • Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia. Reviewed International journal

    Hiroki Shibata, #Atsushi Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    Psychiatry Res.   113 ( 1-2 )   59 - 67   2002.12

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    DOI: 10.1016/S0165-1781(02)00231-7

  • Polymorphism analysis of upstream regions of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): implications for schizophrenia. Reviewed International journal

    #Ayako Tani, #Rumiko Kikuta, #Kanako Itoh, #Akiko Joo, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    Schizophr Res.   58 ( 1 )   83 - 86   2002.11

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    DOI: 10.1016/S0920-9964(02)00161-5

  • Association study of polymorphisms in the coding region of the GluR5 kainate receptor gene (GRIK1) with schizophrenia. Reviewed International journal

    Hiroki Shibata, #Akiko Joo, #Yo Fujii, Ayako Tani, #Chieko Makino, #Naotsugua Hirata, #Rumiko Kikuta, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    Psychiatr Genet.   11 ( 3 )   139 - 144   2001.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00041444-200109000-00005

  • Identification and expression of a mouse ortholog of A2BP1. Reviewed International journal

    Tim-Rasmus Kiehl, Hiroki Shibata, Tramy Vo, Duong P. Huynh, Stefan-M. Pulst

    Mamm Genome.   12 ( 8 )   595 - 601   2001.8

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  • A novel protein with RNA binding motif binds to C-terminal ataxin-2. Reviewed International journal

    Hiroki Shibata, Duong P. Huynh and Stefan-M. Pulst

    Human Molecular Genetics   9 ( 9 )   1303 - 1313   2000.5

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  • RNA-primed PCR. Reviewed International journal

    Hiroki Shibata, Tomoko Tahira, Kenshi Hayashi

    Genome Res.   5 ( 4 )   400 - 403   1995.11

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    DOI: 10.1101/gr.5.4.400

    Repository Public URL: https://hdl.handle.net/2324/7178542

  • Molecular evolution of the duplicated Amy locus in the Drosophila melanogaster species subgroup: concerted evolution only in coding region and an excess of nonsynonymous substitutions in speciation. Reviewed International journal

    #Hiroki Shibata, Tsuneyuki Yamazaki

    Genetics   141 ( 1 )   223 - 236   1995.9

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    Repository Public URL: https://hdl.handle.net/2324/7178541

  • Hexanucleotide repeat expansion in SCA36 reduces the expression of genes involved in ribosome biosynthesis and protein translation

    Morikawa, T; Miura, S; Uchiyama, Y; Hiruki, S; Sun, YR; Fujioka, R; Shibata, H

    JOURNAL OF HUMAN GENETICS   69 ( 9 )   411 - 416   2024.9   ISSN:1434-5161 eISSN:1435-232X

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    Language:English   Publisher:Journal of Human Genetics  

    Hereditary spinocerebellar ataxia (SCA) is a group of clinically and genetically heterogeneous inherited disorders characterized by slowly progressive cerebellar ataxia. We ascertained a Japanese pedigree with autosomal dominant SCA comprising four family members, including two patients. We identified a GGCCTG repeat expansion of intron 1 in the NOP56 gene by Southern blotting, resulting in a molecular diagnosis of SCA36. RNA sequencing using peripheral blood revealed that the expression of genes involved in ribosomal organization and translation was decreased in patients carrying the GGCCTG repeat expansion. Genes involved in pathways associated with ribosomal organization and translation were enriched and differentially expressed in the patients. We propose a novel hypothesis that the GGCCTG repeat expansion contributes to the pathogenesis of SCA36 by causing a global disruption of translation resulting from ribosomal dysfunction.

    DOI: 10.1038/s10038-024-01260-7

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  • Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks

    Ozaki, K; Kato, R; Yasuhara, T; Uchihara, Y; Hirakawa, M; Abe, Y; Shibata, H; Kawabata-Iwakawa, R; Shakayeva, A; Kot, P; Miyagawa, K; Suzuki, K; Matsuda, N; Shibata, A; Yamauchi, M

    SCIENTIFIC REPORTS   14 ( 1 )   18455   2024.8   ISSN:2045-2322

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    Language:English   Publisher:Scientific Reports  

    Although previous studies have reported that pre-mRNA splicing factors (SFs) are involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), their exact role in promoting HR remains poorly understood. Here, we showed that SART1, an SF upregulated in several types of cancer, promotes DSB end resection, an essential first step of HR. The resection-promoting function of SART1 requires phosphorylation at threonine 430 and 695 by ATM/ATR. SART1 is recruited to DSB sites in a manner dependent on transcription and its RS domain. SART1 is epistatic with BRCA1, a major HR factor, in the promotion of resection, especially transcription-associated resection in the G2 phase. SART1 and BRCA1 accumulate at DSB sites in an interdependent manner, and epistatically counteract the resection blockade posed by 53BP1 and RIF1. Furthermore, chromosome analysis demonstrated that SART1 and BRCA1 epistatically suppressed genomic alterations caused by DSB misrepair in the G2 phase. Collectively, these results indicate that SART1 and BRCA1 cooperatively facilitate resection of DSBs arising in transcriptionally active genomic regions in the G2 phase, thereby promoting faithful repair by HR, and suppressing genome instability.

    DOI: 10.1038/s41598-024-68926-2

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  • Duodenal microbiome in chronic kidney disease(タイトル和訳中)

    Kondo Masahiro, Torisu Takehiro, Nagasue Tomohiro, Shibata Hiroki, Umeno Junji, Kawasaki Keisuke, Fujioka Shin, Matsuno Yuichi, Moriyama Tomohiko, Kitazono Takanari

    Clinical and Experimental Nephrology   28 ( 4 )   263 - 272   2024.4   ISSN:1342-1751

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    Language:English   Publisher:(一社)日本腎臓学会  

  • Episodic ataxia type 2 with a novel missense variant (Leu602Arg) in <i>CACNA1A</i>

    Miura, S; Watanabe, E; Senzaki, K; Hiruki, S; Matsumoto, S; Morikawa, T; Uchiyama, Y; Kurata, S; Ochi, M; Ohyagi, Y; Shibata, H

    HUMAN GENOME VARIATION   11 ( 1 )   3   2024.1   ISSN:2054-345X eISSN:2054-345X

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    Language:English   Publisher:Human Genome Variation  

    Autosomal dominant episodic ataxia type 2 (EA2) is caused by variants in CACNA1A. We examined a 20-year-old male with EA symptoms from a Japanese family with hereditary EA. Cerebellar atrophy was not evident, but single photon emission computed tomography showed cerebellar hypoperfusion. We identified a novel nonsynonymous variant in CACNA1A, NM_001127222.2:c.1805T>G (p.Leu602Arg), which is predicted to be functionally deleterious; therefore, this variant is likely responsible for EA2 in this pedigree.

    DOI: 10.1038/s41439-023-00261-w

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  • Episodic ataxia type 2 with a novel missense variant (Leu602Arg) in CACNA1A. Reviewed International journal

    Shiroh Miura, #Emina Watanabe, Kensuke Senzaki, #Shigeyoshi Hiruki, Sayaka Matsumoto, Takuya Morikawa, Yusuke Uchiyama, Seiji Kurata, Masayuki Ochi, Yasumasa Ohyagi, Hiroki Shibata

    Hum Genome Var.   11 ( 1 )   3   2024.1

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    DOI: doi: 10.1038/s41439-023-00261-w.

    Other Link: https://www.frontiersin.org/articles/10.3389/fgene.2023.1155998/full

  • CACNA1A遺伝子に新規ミスセンス変異(Leu602Arg)を有する反復発作性運動失調症2型(Episodic ataxia type 2 with a novel missense variant(Leu602Arg) in CACNA1A)

    Miura Shiroh, Watanabe Emina, Senzaki Kensuke, Hiruki Shigeyoshi, Matsumoto Sayaka, Morikawa Takuya, Uchiyama Yusuke, Kurata Seiji, Ochi Masayuki, Ohyagi Yasumasa, Shibata Hiroki

    Human Genome Variation   11   1 - 3   2024.1

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    Language:English   Publisher:Nature Publishing Group  

    反復発作性運動失調症(EA)2型患者のCACNA1A遺伝子から、新規の非同義変異が認められたため報告する。症例は20歳の日本人男性で、小児期から短時間で消失する運動失調を認め、典型的なEA2表現型を呈していた。また、母親と母方の祖父も20歳時まで同様の運動失調症状が認められ、16歳の弟と9歳の妹も同様の運動失調症状を呈していた。なお、画像所見では脳MRIでは明らかな小脳萎縮が確認できなかったが、脳SPECTにより小脳と脳幹および外側後頭葉で血流量の低下が観察された。エクソームシーケンシングにより、患者のCACNA1A遺伝子から新規のヘテロ接合性非同義変異c.1805T>G;p.Leu602Argが同定され、Sangerシーケンシングにより確認された。なお、本変異は機能的に有害と予測され、ACMG/AMP/CAPガイドラインによりlikely pathogenicに分類された。本例から、患者がEA症状を主訴とする際に脳MRIで小脳萎縮が認められなくても、脳SPECTで小脳の血流量低下を精査することが推奨された。

  • Duodenal microbiome in chronic kidney disease. Reviewed International journal

    #Masahiro Kondo, Takehiro Torisu, Tomohiro Nagasue, Hiroki Shibata, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuichi Matsuno, Tomohiko Moriyama, Takanari Kitazono

    Clin Exp Nephrol.   2023.12

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    DOI: 10.1007/s10157-023-02434-x

    Other Link: https://doi.org/10.1007/s10157-023-02434-x (2023).

  • Case report: Frontotemporal dementia and amyotrophic lateral sclerosis caused by a missense variant (p.Arg89Trp) in the valosin-containing protein gene

    Miura, S; Hiruki, S; Okada, T; Takei, SI; Senzaki, K; Okada, Y; Ochi, M; Tanabe, Y; Ochi, H; Igase, M; Ohyagi, Y; Shibata, H

    FRONTIERS IN GENETICS   14   1155998   2023.5   ISSN:1664-8021 eISSN:1664-8021

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    Frontotemporal dementia and/or amyotrophic lateral sclerosis 6, also known as amyotrophic lateral sclerosis 14, is an autosomal dominant, progressive neurodegenerative disorder caused by various mutations in the valosin-containing protein gene. In this report, we examined a 51-year-old female Japanese patient with frontotemporal dementia and amyotrophic lateral sclerosis. The patient began noticing gait disturbances at the age of 45 years. Neurological examination at the age of 46 years met the Awaji criteria for clinically probable amyotrophic lateral sclerosis. At the age of 49 years, she tended to have poor mood and an aversion to activity. Her symptoms gradually worsened. She required a wheelchair for transport and had difficulty communicating with others because of poor comprehension. She then began to frequently exhibit irritability. Eventually, she was admitted to the psychiatric hospital because uncontrollable violent behavior throughout the day. Longitudinal brain magnetic resonance imaging revealed progressive brain atrophy with temporal dominance, non-progressive cerebellar atrophy, and some non-specific white matter intensities. Brain single photon emission computed tomography showed hypoperfusion in the bilateral temporal lobes and cerebellar hemispheres. Clinical exome sequencing revealed the presence of a heterozygous nonsynonymous variant (NM_007126.5, c.265C>T; p.Arg89Trp) in the valosin-containing protein gene, which was absent in the 1000 Genomes Project, the Exome Aggregation Consortium Database, and the Genome Aggregation Database, and was predicted to be “damaging” by PolyPhen-2 and “deleterious” using SIFT with a Combined Annotation Dependent Depletion score of 35. We also confirmed the absence of this variant in 505 Japanese control subjects. Therefore, we concluded that the variant in the valosin-containing protein gene was responsible for the symptoms of this patient.

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  • Case Report: Frontotemporal dementia and amyotrophic lateral sclerosis caused by a missense variant (p.Arg89Trp) in the valosin-containing protein gene. Reviewed International journal

    Shiroh Miura, #Emina Watanabe, Kensuke Senzaki, #Shigeyoshi Hiruki, Sayaka Matsumoto, Takuya Morikawa, Yusuke Uchiyama, Seiji Kurata, Masayuki Ochi, Yasumasa Ohyagi, Hiroki Shibata

    Front Genet.   14   1155998   2023.5

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    Other Link: https://www.frontiersin.org/articles/10.3389/fgene.2023.1155998/full

  • Oleic acid-containing phosphatidylinositol is a blood biomarker candidate for SPG28 Reviewed International journal

    Takuya Morikawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kosei Moriyama, Gohsuke Hattori, Ryuta Fujioka, Shiroh Miura, Hiroki Shibata

    Biomedicines   11 ( 4 )   1092   2023.4

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    Other Link: https://www.mdpi.com/2227-9059/11/4/1092

  • Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28

    Morikawa, T; Takahashi, M; Izumi, Y; Bamba, T; Moriyama, K; Hattori, G; Fujioka, R; Miura, S; Shibata, H

    BIOMEDICINES   11 ( 4 )   2023.4   ISSN:2227-9059 eISSN:2227-9059

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    Hereditary spastic paraplegia is a genetic neurological disorder characterized by spasticity of the lower limbs, and spastic paraplegia type 28 is one of its subtypes. Spastic paraplegia type 28 is a hereditary neurogenerative disorder with an autosomal recessive inheritance caused by loss of function of DDHD1. DDHD1 encodes phospholipase A1, which catalyzes phospholipids to lysophospholipids such as phosphatidic acids and phosphatidylinositols to lysophosphatidic acids and lysophoshatidylinositols. Quantitative changes in these phospholipids can be key to the pathogenesis of SPG28, even at subclinical levels. By lipidome analysis using plasma from mice, we globally examined phospholipids to identify molecules showing significant quantitative changes in Ddhd1 knockout mice. We then examined reproducibility of the quantitative changes in human sera including SPG28 patients. We identified nine kinds of phosphatidylinositols that show significant increases in Ddhd1 knockout mice. Of these, four kinds of phosphatidylinositols replicated the highest level in the SPG28 patient serum. All four kinds of phosphatidylinositols contained oleic acid. This observation suggests that the amount of oleic acid-containing PI was affected by loss of function of DDHD1. Our results also propose the possibility of using oleic acid-containing PI as a blood biomarker for SPG28.

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  • Hereditary Congenital Methemoglobinemia Diagnosed at the Age of 79 Years: A Case Report

    Nakata Marohito, Yokota Naoko, Tabata Kazuhiko, Morikawa Takuya, Shibata Hiroki, Kenzaka Tsuneaki

    Medicina   59 ( 3 )   615   2023.3   eISSN:16489144

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    Background: Cardiopulmonary disorders are the most common cause of central cyanosis, and methemoglobinemia is often overlooked in the differential diagnosis of patients with central cyanosis. In most cases, methemoglobinemia is acquired and hereditary congenital methemoglobinemia is rare. Only a few case reports of congenital methemoglobinemia can be found in PubMed. To date, only four cases of congenital methemoglobinemia diagnosed after the age of 50 years have been reported. / Case Presentation: A 79-year-old Japanese woman presented at our hospital with the chief complaints of dyspnea and cyanosis. She exhibited cyanosis of the lips and extremities, and her SpO2 was 80%, with oxygen administration at 5 L/min. Blood gas analysis revealed a PaO2 of 325.4 mmHg and methemoglobin level of 36.9%. The SpO2 and PaO2 values were dissociated, and methemoglobin levels were markedly elevated. Genetic analysis revealed a nonsynonymous variant in the gene encoding nicotinamide adenine dinucleotide cytochrome (NADH) B5 reductase 3 (CYB5R3), and the patient was diagnosed with congenital methemoglobinemia. Conclusions: It is important to consider methemoglobinemia in the differential diagnosis of patients with central cyanosis. At 79 years of age, our patient represents the oldest patient with this diagnosis. This report indicates that it is crucial to consider the possibility of methemoglobinemia regardless of the patient’s age.

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  • Hereditary Congenital Methemoglobinemia Diagnosed at the Age of 79 Years: A Case Report Reviewed International journal

    Marohito Nakata, Naoko Yokota, Kazuhiko Tabata, Takuya Morikawa, Hiroki Shibata, Tsuneaki Kenzaka

    Medicina (Kaunas)   59 ( 3 )   615   2023.3

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    Other Link: https://www.mdpi.com/1648-9144/59/3/615

    Repository Public URL: https://hdl.handle.net/2324/7173585

  • Hereditary Congenital Methemoglobinemia Diagnosed at the Age of 79 Years: A Case Report

    Nakata, M; Yokota, N; Tabata, K; Morikawa, T; Shibata, H; Kenzaka, T

    MEDICINA-LITHUANIA   59 ( 3 )   2023.3   ISSN:1010-660X eISSN:1648-9144

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    Background: Cardiopulmonary disorders are the most common cause of central cyanosis, and methemoglobinemia is often overlooked in the differential diagnosis of patients with central cyanosis. In most cases, methemoglobinemia is acquired and hereditary congenital methemoglobinemia is rare. Only a few case reports of congenital methemoglobinemia can be found in PubMed. To date, only four cases of congenital methemoglobinemia diagnosed after the age of 50 years have been reported. Case Presentation: A 79-year-old Japanese woman presented at our hospital with the chief complaints of dyspnea and cyanosis. She exhibited cyanosis of the lips and extremities, and her SpO2 was 80%, with oxygen administration at 5 L/min. Blood gas analysis revealed a PaO2 of 325.4 mmHg and methemoglobin level of 36.9%. The SpO2 and PaO2 values were dissociated, and methemoglobin levels were markedly elevated. Genetic analysis revealed a nonsynonymous variant in the gene encoding nicotinamide adenine dinucleotide cytochrome (NADH) B5 reductase 3 (CYB5R3), and the patient was diagnosed with congenital methemoglobinemia. Conclusions: It is important to consider methemoglobinemia in the differential diagnosis of patients with central cyanosis. At 79 years of age, our patient represents the oldest patient with this diagnosis. This report indicates that it is crucial to consider the possibility of methemoglobinemia regardless of the patient’s age.

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  • A Japanese family with dystonia due to a pathogenic variant in <i>SGCE</i>

    Morikawa, T; Miura, S; Fan, LM; Watanabe, E; Fujioka, R; Motooka, H; Yasumoto, S; Uchiyama, Y; Shibata, H

    HUMAN GENOME VARIATION   9 ( 1 )   29   2022.8   ISSN:2054-345X eISSN:2054-345X

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    Dystonia (DYT) is a heterogeneous neurological disorder, and there are many types of DYT depending on the responsible genes. DYT11 is an autosomal dominant DYT caused by functional variants in the SGCE gene. We examined a Japanese patient with myoclonic dystonia. By using exome analysis, we identified a rare variant in the SGCE gene, NM_003919.3: c.304C > T [Arg102*], in this patient. Therefore, this patient has been molecularly diagnosed with DYT11. By Sanger sequencing, we confirmed that this variant was paternally inherited in this patient. By allele-specific PCR, we confirmed that the maternally inherited normal allele of SGCE was silenced, and only the paternally inherited variant allele was expressed in this patient. Despite the pathogenicity, identical variants have been recurrently reported in eight independent families from different ethnicities, suggesting recurrent mutations at this mutational hotspot in SGCE.

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  • A Japanese family with dystonia due to a pathogenic variant in SGCE. Reviewed International journal

    Takuya Morikawa, Shiroh Miura, #Luoming Fan, #Emina Watanabe, Ryuta Fujioka, Hiromichi Motooka, Shingo Yasumoto, Yusuke Uchiyama, Hiroki Shibata

    Hum Genome Var.   9   29   2022.8

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    Other Link: https://www.nature.com/articles/s41439-022-00207-8

  • SGCE遺伝子の病的変異に起因したジストニアの日本人家系(A Japanese family with dystonia due to a pathogenic variant in SGCE)

    Morikawa Takuya, Miura Shiroh, Fan Luoming, Watanabe Emina, Fujioka Ryuta, Motooka Hiromichi, Yasumoto Shingo, Uchiyama Yusuke, Shibata Hiroki

    Human Genome Variation   9   1 - 3   2022.8

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    SGCE遺伝子に病的変異が検出された、ミオクローヌス性ジストニア症候群の日本人症例を報告した。症例は19歳女性で、不随意運動の家族歴は有さなかったが、8歳時に右手けいれんを発症し、右手で物を把持することが困難になった。また、症状は精神的ストレスにより悪化し、徐々に左手にも症状が及んだため、クロナゼパム投与が施行された。投薬後、症状は劇的に改善され、ミオクローヌス性ジストニア症候群と診断された。また、エクソームシーケンシングを行ったところ、SGCE遺伝子に稀な変異c.304C>T[Arg102*]が同定されたため、遺伝性ジストニアDYT11と確定診断された。遺伝子解析結果から、さらに、患者と両親のSangerシーケンシングを行ったところ、これらの変異が父性遺伝であることが確認され、アレル特異的PCR法により、母性遺伝によるSGCE遺伝子の正常アレルがサイレンシングされ、父性遺伝した変異型アレルのみ発現したことが明らかにされた。なお、これらの病的変異は、民族が異なる血縁関係のない8家系にも報告されていることから、本変異はホットスポット変異による反復突然変異と考えられた。

  • The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy

    Nagasue, T; Hirano, A; Torisu, T; Umeno, J; Shibata, H; Moriyama, T; Kawasaki, K; Fujioka, S; Fuyuno, Y; Matsuno, Y; Esaki, M; Kitazono, T

    DIGESTION   103 ( 4 )   308 - 318   2022.7   ISSN:0012-2823 eISSN:1421-9867

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    Introduction: An association has been found between human-gut microbiota and various diseases (e.g., metabolic disease) by analyzing fecal or colonic microbiota. Despite the importance of the small intestinal microbiota, sampling difficulties prevent its full analysis. We investigated the composition and metagenomic functions of microbiota along the small intestine and compared them with the microbiota from feces and from other gastrointestinal (GI) sites. Methods: Mucosal samples from the six GI sites (stomach, duodenum, distal jejunum, proximal ileum, terminal ileum, and rectum) were collected under balloon-assisted enteroscopy. Fecal samples were collected from all participants. The microbial structures and metagenomic functions of the small intestinal mucosal microbiota were compared with those from feces and other GI sites using 16S ribosomal RNA gene sequencing. Results: We analyzed 133 samples from 29 participants. Microbial beta diversity analysis showed that the jejunum and ileum differed significantly from the lower GI tract and the feces (p < 0.001). Jejunal and duodenal microbiotas formed similar clusters. Wide clusters spanning the upper and lower GI tracts were observed with the ileal microbiota, which differed significantly from the jejunal microbiota (p < 0.001). Veillonella and Streptococcus were abundant in the jejunum but less so in the lower GI tract and feces. The metagenomic functions associated with nutrient metabolism differed significantly between the small intestine and the feces. Conclusions: The fact that the compositional structures of small intestinal microbiota differed from those of fecal and other GI microbiotas reveals that analyzing the small intestinal microbiota is necessary for association studies on metabolic diseases and gut microbiota.

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  • Active Expression of Genes for Protein Modification Enzymes in Habu Venom Glands

    Isomoto, A; Shoguchi, E; Hisata, K; Inoue, J; Sun, YR; Inaba, K; Satoh, N; Ogawa, T; Shibata, H

    TOXINS   14 ( 5 )   2022.5   eISSN:2072-6651

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    Genes encoding snake venom toxins have been studied extensively. However, genes involved in the modification and functioning of venom proteins are little known. Protobothrops is a genus of pit vipers, which are venomous and inhabit the Nansei (Southwest) islands of Japan, Tai-wan China, Vietnam, Thailand, Myanmar, Nepal, Bhutan, and India. Our previous study decoded the genome of Protobothrops flavoviridis, a species endemic to the Nansei Islands, Japan, and revealed unique evolutionary processes of some venom genes. In this study, we analyzed genes that are highly expressed in venom glands to survey genes for candidate enzymes or chaperone proteins involved in toxin folding and modification. We found that, in addition to genes that encode venom proteins and ribosomal proteins, genes that encode protein disulfide isomerase (PDI) family members (orthologs of human P4HB and PDIA3), Selenoprotein M (SELENOM), and Calreticulin (CALR) are highly expressed in venom glands. Since these enzymes or chaperones are involved in protein modification and potentially possess protein folding functions, we propose that P4HB, SELENOM, CALR, and PDIA3 encode candidate enzymes or chaperones to confer toxic functions upon the venom transcriptome.

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  • The compositional structure of the small intestinal microbial community via balloon-assisted enteroscopy Reviewed International journal

    #Tomohiro Nagasue, Atsushi Hirano, Takehiro Torisu, Junji Umeno, Hiroki Shibata, Tomohiko Moriyama, Keisuke Kawasaki, Shin Fujioka, Yuta Fuyuno, Yuichi Matsuno, Motohiro Esaki, Takanari Kitazono

    Digestion   8 ( 1 )   1 - 11   2022.4

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  • One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study Reviewed International journal

    #Yuichi Matsuno, Takehiro Torisu, Junji Umeno, Hiroki Shibata, Atsushi Hirano, Yuta Fuyuno, Yasuharu Okamoto, Shin Fujioka, Keisuke Kawasaki, Tomohiko Moriyama, #Tomohiro Nagasue, Keizo Zeze, Yoichiro Hirakawa, Shinichiro Kawatoko, Yutaka Koga, Yoshinao Oda, Motohiro Esaki, Takanari Kitazono

    Intest Res.   20 ( 2 )   260 - 268   2022.4

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  • One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study

    Matsuno, Y; Torisu, T; Umeno, J; Shibata, H; Hirano, A; Fuyuno, Y; Okamoto, Y; Fujioka, S; Kawasaki, K; Moriyama, T; Nagasue, T; Zeze, K; Hirakawa, Y; Kawatoko, S; Koga, Y; Oda, Y; Esaki, M; Kitazono, T

    INTESTINAL RESEARCH   20 ( 2 )   260 - +   2022.4   ISSN:1598-9100

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    Background/Aims: Recent studies suggested a favorable effect of indigo naturalis (IN) in inducing remission for refractory ulcerative colitis (UC), however, the maintenance effect of IN for patients with UC remains unknown. Therefore, we conducted a prospective uncontrolled open-label study to analyze the efficacy and safety of IN for patients with UC. Methods: Patients with moderate to severe active UC (clinical activity index [CAI] ≥ 8) took 2 g/day of IN for 52 weeks. CAI at weeks 0, 4, 8, and 52 and Mayo endoscopic subscore (MES) and Geboes score (GS) at weeks 0, 4, and 52 were assessed. Clinical remission (CAI ≤ 4), mucosal healing (MES ≤ 1), and histological healing (GS ≤ 1) rates at each assessment were evaluated. Overall adverse events (AEs) during study period were also evaluated. The impact of IN on mucosal microbial composition was assessed using 16S ribosomal RNA gene sequences. Results: Thirty-three patients were enrolled. The rates of clinical remission at weeks 4, 8, and 52 were 67%, 76%, and 73%, respectively. The rates of mucosal healing at weeks 4 and 52 were 48% and 70%, respectively. AEs occurred in 17 patients (51.5%) during follow-up. Four patients (12.1%) showed severe AEs, among whom 3 manifested acute colitis. No significant alteration in the mucosal microbial composition was observed with IN treatment. Conclusions: One-year treatment of moderate to severe UC with IN was effective. IN might be a promising therapeutic option for maintaining remission in UC, although the relatively high rate of AEs should be considered. (Intest Res 2022;20:260-268

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  • グアニル酸による PC―12細胞への効果

    藤岡 竜太, 岡本 昭, #範 駱鳴, 三浦 史郎, 柴田 弘紀

    別府大学短期大学部紀要   41   73 - 77   2022.2

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  • 日本人の家族性無症候性高CK血症におけるDAG1遺伝子の新規1bp欠失変異(A novel 1-bp deletion variant in DAG1 in Japanese familial asymptomatic hyper-CK-emia)

    Fan Luoming, Miura Shiroh, Shimojo Tomofumi, Sugino Hirotoshi, Fujioka Ryuta, Shibata Hiroki

    Human Genome Variation   9   1 - 3   2022.2

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    広島県に居住する日本人親子からDAG1遺伝子の新規変異が検出され、無症候性(特発性)高クレアチンキナーゼ血症(ASCK)が認められたため報告した。家族構成は両親と14歳と10歳の男児2人と発端者の11歳女児1人の5人家族で、父親ときょうだい3人から血清中CK高値が認められたが、明確な神経学的異常はみられなかった。次に、発端者である長女と次男の弟について、全エクソームシークエンシングとSangerシークエンシングを行ったところ、DAG1遺伝子のエクソン3領域に、新規の1bp欠失変異c.930delC:p.R311Gfs*70が共通して同定された。これらの変異により、コドン477領域で未成熟な翻訳終止が生じ、必須となるDAG1ドメインが完全に欠如したタンパク質産生が惹起されたと推測された。なお、本例で認められたDAG1遺伝子の新規の1塩基欠失変異は、ASCKの顕性遺伝(優性遺伝)による病原性変異と推測された。

  • A novel 1-bp deletion variant in <i>DAG1</i> in Japanese familial asymptomatic hyper-CK-emia

    Fan, LM; Miura, S; Shimojo, T; Sugino, H; Fujioka, R; Shibata, H

    HUMAN GENOME VARIATION   9 ( 1 )   4   2022.1   ISSN:2054-345X eISSN:2054-345X

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    #Luoming Fan, Shiroh Miura, #Tomofumi Shimojo, Hirotoshi Sugino, Ryuta Fujioka, Hiroki Shibata

    Hum Genome Var.   9 ( 1 )   4   2022.1

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  • Detection of novel fusion genes by next generation sequencing-based targeted RNA-sequencing analysis in adenoid cystic carcinoma of head and neck. Reviewed International journal

    Eri Shibata, Kei-ichi Morita, Kou Kayamori, Shoichiro Tange, Hiroki Shibata, Yosuke Harazono, Yasuyuki Michi, Tohru Ikeda, Hiroyuki Harada, Issei Imoto, Tetsuya Yoda

    Oral Surg Oral Med Oral Pathol Oral Radiol.   132 ( 4 )   426 - 433   2021.10

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  • Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma. Reviewed International journal

    #Takahide Tanaka, Yuichi Matsuno, Takehiro Torisu, Hiroki Shibata, Atsushi Hirano, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuta Fuyuno, Tomohiko Moriyama, Motohiro Esaki, Takanari Kitazono

    Medicine (Baltimore) 100 (38): e27287 (2021).   100 ( 38 )   e27287   2021.9

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  • A Japanese hereditary spastic paraplegia family with a rare nonsynonymous variant in the SPAST gene. Reviewed International journal

    #Takuya Morikawa, Shiroh Miura, Takahisa Tateishi, Kazuhito Noda, Hiroki Shibata

    Hum Genome Var.   8 ( 21 )   2021.5

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  • Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations. Reviewed International journal

    Commun Biol.   3 ( 1 )   437 - 437   2020.8

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  • Mucosal dysbiosis in patients with gastrointestinal follicular lymphoma. Reviewed International journal

    #Keizo Zeze, Atsushi Hirano, Takehiro Torisu, Motohiro Esaki, Hiroki Shibata, Tomohiko Moriyama, Junji Umeno, Shin Fujioka, Yasuharu Okamoto, Yuta Fuyuno, Yuichi Matsuno, Takanari Kitazono

    Hematol Oncol.   38 ( 2 )   181 - 188   2020.4

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  • Discovery of the gene encoding novel Small Serum Protein (SSP), SSP-6, of Protobothrops flavoviridis snake and evolutionary pathway of SSPs. Reviewed International journal

    #Kento Inamaru, #Ami Takeuchi, #Marie Maeda, Hiroki Shibata, Yasuyuki Fukumaki, Naoko Oda-Ueda, Shosaku Hattori, Motonori Ohno, Takahito Chijiwa

    Toxins (Basel)   12 ( 3 )   177 - 177   2020.3

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  • Growth responses of PC-12 cells to dried shiitake (Lentinula edodes) extract.

    Ryuta Fujioka, Akira Okamoto, #Akihiro Nagano, #Takuya Morikawa, Hiroki Shibata

    Bulletin of Bepppu University Junior College   39   63 - 67   2020.2

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  • The Indian cobra genome and transcriptome enables comprehensive identification of venom toxins. Reviewed International journal

    Nat Genet.   52   106 - 117   2020.1

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  • TDRKH is a candidate gene responsible for an autosomal dominant distal hereditary motor neuropathy. Reviewed International journal

    Shiroh Miura, #Kengo Kosaka, Ryuta Fujioka, Yusuke Uchiyama, #Tomofumi Shimojo, #Takuya Morikawa, Azusa Irie, Takayuki Taniwaki, Hiroki Shibata

    Eur J Med Genet.   62 ( 12 )   103594   2019.11

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  • Unique structure (construction and configuration) and evolution of the array of small serum protein genes of Protobothrops flavoviridis snake. Reviewed International journal

    Takahito Chijiwa, #Kento Inamaru, #Ami Takeuchi, #Marie Maeda, #Kazuaki Yamaguchi, Hiroki Shibata, Shosaku Hattori, Naoko Oda-Ueda, Motonori Ohno

    Biosci Rep.   39 ( 7 )   BSR20190560 - BSR20190560   2019.7

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  • Correlation analysis between thyroid-related hormones and the plasma concentration of amino acids.

    Ryuta Fujioka, Junko Nagai, Yoshihiro Yamanishi, Hiroki Shibata

    Bulletin of Bepppu University Junior College   38   17 - 23   2019.2

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  • Ancient genomics reveals four prehistoric migration waves into Southeast Asia. Reviewed International journal

    Science   361   88 - 92   2018.7

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  • A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes Reviewed International journal

    #Kae Koganebuchi, Takashi Gakuhari, Hirohiko Takeshima, Kimitoshi Sato, Kiyotaka Fujii, Toshihiro Kumabe, Satoshi Kasagi, Takehiro Sato, Atsushi Tajima, Hiroki Shibata, Motoyuki Ogawa, Hiroki Oota

    PLoS One   13 ( 7 )   e0200170   2018.7

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  • An albino mutant of the Japanese rat snake (Elaphe climacophora) carries a nonsense mutation in the tyrosinase gene. Reviewed International journal

    #Shuzo Iwanishi, Shohei Zaitsu, Hiroki Shibata, Eiji Nitasaka

    Genes Genet Syst.   93   163 - 167   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Spinocerebellar ataxia 27 with a novel nonsense variant (Lys177X) in FGF14. Reviewed International journal

    Shiroh Miura, Kengo Kosaka, Ryuta Fujioka, Yusuke Uchiyama, Tomofumi Shimojo, Takuya Morikawa, Azusa Irie, Takayuki Taniwaki, Hiroki Shibata

    Eur J Med Genet.   62   172 - 176   2018.7

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  • A comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis. Reviewed International journal

    #Atushi Hirano, Junji Umeno, Yasuharu Okamoto, Hiroki Shibata, Yoshitoshi Ogura, Tomohiko Moriyama, Takehiro Torisu, Shin Fujioka, Yuta Fuyuno, Yutaka Kawarabayashi, Takayuki Matsumoto, Takanari Kitazono, Motohiro Esaki

    J Gastroenterol Hepatol.   33   1590 - 1597   2018.2

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  • 家族歴のない脊髄小脳失調症6型の遺伝学的解析

    藤岡竜太, 三浦史郎, 山田浩平, 柴田弘紀

    別府大学短期大学紀要   37   87 - 91   2018.2

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    電位依存性カルシウムチャネルα1Aサブユニット遺伝子であるCACNA1A遺伝子上にあるDNAの三塩基配列CAGリピートの異常伸長が脊髄小脳失調症6型(Spinocerebellar ataxia type 6: SCA6)の発症に関わることが知られている。SCA6の原因遺伝子であるCACNA1A遺伝子上ではCAGリピート数が健常者では4から19, 罹患者では21から33となる。また、SCA6は家族歴のある常染色体優性遺伝性の罹患者が多く、日本では優性遺伝性の脊髄小脳失調症の約30%を占めている。本研究では孤発性(非遺伝性)のSCA6の罹患者および両親の末梢血検体を使用し、遺伝学的解析によるCAGリピート異常から家族歴の遺伝性を検証した。結果としてSCA6の罹患者はCAGリピートの異常伸長(変異アレルでリピート数23)が認められた。さらに遺伝学的解析により両親とも健常であるが、おそらく父親由来の正常アレルから罹患者の変異アレルに表現促進現象が起こったのではないかと示唆された。これらのことから孤発性の症例でも遺伝学的解析により原因の究明ができる可能性が考えられる。

  • A new mutation of congenital methemoglobinemia exacerbated after methylene blue treatment. Reviewed International journal

    Fuminori Yamaji, Akio Soeda, Hiroki Shibata, #Takuya Morikawa, Kodai Suzuki, Shozo Yoshida, Shinji Ogura.

    Acute Med Surg.   5   199 - 201   2018.2

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  • DNA methylation of the Klf14 gene region on whole blood provide prediction for the chronic inflammation at the adipose tissue. Reviewed International journal

    #Chihiro Iwaya, Hidetoshi Kitajima, Ken Yamamoto, Yasutaka Maeda, Noriyuki Sonoda, Hiroki Shibata, Toyoshi Inoguchi.

    Biochem Biophys Res Commun.   497   908 - 915   2018.2

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  • Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. Reviewed International journal

    #Itsuki Taniguchi, #Chihiro Iwaya, Keizo Ohnaka, Hiroki Shibata, Ken Yamamoto

    Hum Genomics.   11   8 - 8   2017.5

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    DOI: 10.1186/s40246-017-0106-6

  • Unverricht-Lundborg病検体を使用したPCRによるCSTB(Cystatin B)遺伝子の異常リピートの検討

    藤岡竜太, 三浦史郎, #青木浩介, 本岡大道, 柴田弘紀

    別府大学短期大学紀要   36   71 - 75   2017.2

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    CSTB(Cystatin B)遺伝子の異常リピートにより引き起こされる進行性ミオクローヌスてんかんの一病型であるウンフェルリヒト・ルントボルク病(Unverricht-Lundborg disease:ULD)の可能性のある検体の遺伝子解析研究である。進行性ミオクローヌスてんかんの中でCSTB(Cystatin B)遺伝子のリピート異常が原因の疾患はULDとして知られている。ULDを調べるために放射性同位体(Radioisotope:RI)を使用したサザンブロッティングによる解析が行われる。そこで本研究では、簡便なポリメラーゼ連鎖反応(Polymerase chain reaction: PCR)を使用してCSTBの異常リピートの検出を試み、診断手法の確立およびULDの診断に寄与できないか検討した。PCRの結果、健常者と比較して患者では異常リピートと考えられるDNA増幅を確認したがサンガーシークエンスによる配列確認により異常リピートではなく、別の配列の挿入が示唆される結論に至った。

  • Structural comparison and evolution of filaggrin gene within primates. Reviewed International journal

    Vanessa Romero, Kazuyoshi Hosomichi, Hiroki Shibata, Hirofumi Nakaoka, Ituro Inoue

    BMC Evol Biol.   17 ( 1 )   10 - 10   2017.1

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    DOI: 10.1186/s12862-016-0851-5.

  • SPTBN2にミスセンス変異を認めた脊髄小脳失調症

    藤岡竜太, 三浦史郎, 貴田浩志, 柴田弘紀

    別府大学短期大学紀要   35   11 - 16   2016.2

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    本研究は、日本人の脊髄小脳失調症 (Spinocerebellar ataxia: SCA)症例の遺伝解析研究である。本症例は臨床的にSCAタイプ5に矛盾せず、頭部MRI画像では小脳萎縮が認められ、脳幹は保たれていた。遺伝学的解析により、SCA5の原因遺伝子であるβ-IIIスペクトリン遺伝子(SPTBN2)の新規非同義変異(c.924 G>C, p. E308D)が認められた。その遺伝子は細胞骨格たんぱく質をコードして 11番染色体に位置しており、E308Dの変異はホットスポットに局在していた。日本人健常者507人を検討した結果、9人が同様の変異を有していた。したがって、SCA5の責任遺伝子内のミスセンス変異であるE308Dが責任変異ではない可能性が示唆された。

  • The finding of a group IIE phospholipase A2 gene in a specified segment of Protobothrops flavoviridis genome and its possible evolutionary relationship to group IIA phospholipase A2 genes. Reviewed International journal

    #Kazuaki Yamaguchi, Takahito Chijiwa, Naoki Ikeda, Hiroki Shibata, Yasuyuki Fukumaki, Naoko Oda-Ueda, Shosaku Hattori, Motonori Ohno

    Toxins   6   3471 - 3487   2014.12

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    DOI: 10.3390/toxins6123471

  • Diversity in the matrix structure of eggshells in the testudines (reptilia). Reviewed International journal

    Satoshi Kusuda, Yuichirou Yasukawa, Hiroki Shibata, Tomomi Saito, Osamu Doi, Yutaka Ohya, Norio Yoshizaki

    Zoolog Sci.   30 ( 5 )   2013.5

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  • Crohn’s disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation. Reviewed International journal

    156 ( 7 )   2012.1

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    Risk alleles for complex diseases are spread widely throughout human populations. However, little is known about the geographic distribution of risk allele frequencies, which may contribute to geographic differences in disease susceptibility and prevalence. Here we focus on Crohn’s disease (CD) as a model for the evolutionary study of complex disease alleles. Recent genome-wide association studies and classical linkage analyses have identified more than 70 susceptible genomic regions for CD in Europeans, but only a few have been confirmed in non-European populations. Our analysis of eight European-specific susceptibility genes using HapMap data shows that at the NOD2 locus the CD-risk alleles are linked with a haplotype specific to CEU at a frequency that is significantly higher compared to the entire genome. We subsequently examined nine global populations and found that the CD-risk alleles spread through hitchhiking with a high-frequency haplotype (H1) exclusive to Europeans. To examine the neutrality of NOD2, we performed phylogenetic network analyses, coalescent simulation, protein structural prediction, characterization of mutation patterns, and estimations of population growth and time to most recent common ancestor (TMRCA). We found that while H1 was significantly prevalent in European populations, the H1 TMRCA predated human migration out of Africa. H1 is likely to have undergone negative selection because (i) the root of H1 genealogy is defined by a pre-existing amino acid substitution that causes serious conformational changes to the NOD2 protein, (ii) the haplotype has almost become extinct in Africa, and (iii) the haplotype has not been affected by the recent European expansion reflected in the other haplotypes. Nevertheless, H1 has survived in European populations, suggesting that the haplotype is advantageous to the populations. We propose that several CD-risk alleles, which destabilize and disrupt the NOD2 protein, have been maintained by natural selection on standing variation because the deleterious haplotype of NOD2 is advantageous in diploid individuals due to heterozygote advantage and/or intergenic interactions.

  • Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia. Reviewed International journal

    #Xiangdong Deng, #Hiromi Takaki, #Lixiang Wang, Tosihide Kuroki, Tatsuo Nakahara, Kijiro Hashimoto, Hideaki Ninomiya, Tadao Arinami, Toshiya Inada, Hiroshi Ujike, Masanari Itokawa, Mamoru Tochigi, Yuichiro Watanabe, Toshiyuki Someya, Hiroshi Kunugi, Nakao Iwata, Norio Ozaki, Hiroki Shibata, Yasuyuki Fukumaki

    Am J Med Genet Neuropsychiatr Genet.   156 ( 7 )   850 - 858   2011.9

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    Spastic paraplegia type 4 (SPG4) is the most common autosomal dominant hereditary SPG caused by mutations in the SPAST gene. We studied the four- generation pedigree of a Japanese family with autosomal dominant hereditary SPG both clinically and genetically. Twelve available family members (ten affected; two unaffected) and two spouses were enrolled in the study. The clinical features were hyperreflexia in all four limbs, spasticity of the lower extremities, impaired vibration sense, mild cognitive impairment confirmed by the Wechsler Adult Intelligence Scale—Third Edition, and peripheral neuropathy confirmed by neurophysiological examinations. All four female patients experienced miscarriages. The cerebrospinal fluid tau levels were mildly increased in two of three patients examined. Linkage analyses revealed the highest logarithm of odds score of 2.64 at 2p23-p21 where the SPAST gene is located. Mutation scanning of the entire exonic regions of the SPAST gene by direct sequencing revealed no mutations. Exonic copy number analysis by real- time quantitative polymerase chain reaction revealed hetero- zygous deletion of exons 1 to 4 of the SPAST gene. Breakpoint analysis showed that the centromeric breakpoint was located within intron 4 of SPAST while the telomeric breakpoint was located within intron 3 of the neighboring DPY30 gene, causing a deletion of approximately 70 kb ranging from exons 1 to 3 of DPY30 to exons 1 to 4 of SPAST. To our knowledge, this is the first report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree.

  • Partial SPAST and DPY30 deletions in a Japanese spastic paraplegia type 4 family. Reviewed International journal

    Shiroh Miura, Hiroki Shibata, Hiroshi Kida, Kazuhito Noda, Takayuki Toyama, Naoka Iwasaki, Akiko Iwaki, Mitsuyoshi Ayabe, Hisamichi Aizawa, Takayuki Taniwaki, Yasuyuki Fukumaki.

    Neurogenetics   12 ( 1 )   25 - 31   2010.9

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    Abstract Spastic paraplegia type 4 (SPG4) is the most common autosomal dominant hereditary SPG caused by mutations in the SPAST gene. We studied the four- generation pedigree of a Japanese family with autosomal dominant hereditary SPG both clinically and genetically. Twelve available family members (ten affected; two unaffected) and two spouses were enrolled in the study. The clinical features were hyperreflexia in all four limbs, spasticity of the lower extremities, impaired vibration sense, mild cognitive impairment confirmed by the Wechsler Adult Intelligence Scale—Third Edition, and peripheral neuropathy confirmed by neurophysiological examinations. All four female patients experienced miscarriages. The cerebrospinal fluid tau levels were mildly increased in two of three patients examined. Linkage analyses revealed the highest logarithm of odds score of 2.64 at 2p23-p21 where the SPAST gene is located. Mutation scanning of the entire exonic regions of the SPAST gene by direct sequencing revealed no mutations. Exonic copy number analysis by real- time quantitative polymerase chain reaction revealed hetero- zygous deletion of exons 1 to 4 of the SPAST gene. Breakpoint analysis showed that the centromeric breakpoint was located within intron 4 of SPAST while the telomeric breakpoint was located within intron 3 of the neighboring DPY30 gene, causing a deletion of approximately 70 kb ranging from exons 1 to 3 of DPY30 to exons 1 to 4 of SPAST. To our knowledge, this is the first report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree.

    Other Link: http://www.springerlink.com/content/d87437661v732711/

  • Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. Reviewed International journal

    #Shinsaku Arai, Hiroki Shibata, Mayumi Sakai, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki.

    Psychiatric Genet.   19 ( 1 )   6 - 13   2009.2

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  • Hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough. Reviewed International journal

    #Shiroh Miura, Hiroki Shibata, Hiroshi Kida, Kazuhito Noda, Ken Yamamoto, Akiko Iwaki, Mitsuyoshi Ayabe, Hisamichi Aizawa, Takayuki Taniwaki, Yasuyuki Fukumaki

    J Neurol Sci.   273 ( 1-2 )   88 - 92   2008.10

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  • Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. Reviewed International journal

    #Xiangdong Deng, #Noriaki Sagata, #Naoko Takeuchi, #Masami Tanaka, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Hiroki Shibata, Yasuyuki Fukumaki

    BMC Psychiatry   8 ( 1 )   2008.7

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  • Heterozygous deletion of ITPR1, but not SUMF1 in spinocerebellar ataxia type 16. Reviewed International journal

    Akiko Iwaki, Yuji Kawano Y, #Shiroh Miura, Hiroki Shibata, Dai Matsuse, Wei Li, Hirokazu Furuya, Yasumasa Ohyagi, Takayuki Taniwaki, Jun-ichi Kira, Yasuyuki Fukumaki

    J Med Genet.   45 ( 1 )   32 - 35   2008.1

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  • Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3 and SLC1A6 with schizophrenia. Reviewed International journal

    #Xiangdong Deng, Hiroki Shibata, #Naoko Takeuchi, #Shinako Rachi, Mayumi Sakai, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

    Am J Med Genet B Neuropsychiatr Genet.   144 ( 3 )   271 - 278   2007.4

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  • The CNTN4 locus at 3p26 is a candidate gene of SCA16 Reviewed International journal

    #Shiroh Miura, Hiroki Shibata, Hirokazu Furuya, Yasumasa Ohyagi, Manabu Osoegawa, Yasushi Miyoshi, Hiromi Matsunaga, #Atsushi Shibata, #Naoki Matsumoto, Akiko Iwaki, Takayuki Taniwaki, Kikuchi H, Jun-ichi Kira, Yasuyuki Fukumaki

    Neurology   67 ( 7 )   1236 - 1241   2006.10

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  • Genome-wide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia loci on chromosomes 1p, 14q and 20p. Reviewed International journal

    The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG).

    Am J Hum Genet.   77   937 - 944   2005.12

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  • Association Study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Reviewed International journal

    #Hee Jae Lee, Ji Young Song, Jong Woo Kim, Sheng-Yu Jin, Mi Suk Hong, Jin Kyoung Park, Joo-Ho Chung, Hiroki Shibata, Yasuyuki Fukumaki

    Behav Brain Funct.   1   15   2005.8

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  • Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): analysis of association with schizophrenia. Reviewed International journal

    #Akiko Joo, Hiroki Shibata, Hideaki Ninomiya, Hiroaki Kawasaki, Nobutada Tashiro, Yasuyuki Fukumaki

    Mol Psychiatry.   6 ( 2 )   186 - 192   2001.3

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    DOI: 10.1038/sj.mp.4000841

  • Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits. Reviewed International journal

    #Hiroshi Mitsuyasu, #Naotsugu Hirata, #Yasuyoshi Sakai, Hiroki Shibata, Yasuhiko Takeda, Hideaki Ninomiya, Hiroaki Kawasaki, Nobutada Tashiro, Yasuyuki Fukumaki

    J Hum Genet.   46 ( 1 )   26 - 31   2001.1

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    DOI: 10.1007/s100380170120

  • The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans. Reviewed International journal

    Tim-Rasmus Kiehl, Hiroki Shibata, Stefan-M. Pulst

    J Mol Neurosci.   15 ( 3 )   231 - 241   2000.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1385/JMN:15:3:231

  • Molecular analysis of a-thalassemia in Nepal: correlation with malaria endemicity. Reviewed International journal

    #Yasuyoshi Sakai, Shigeru Kobayashi, Hiroki Shibata, Hiroyasu Furuumi, Toshiyasu Endo, Supan Fucharoen, Shinjiro Hamano, Gopal P. Acharya, Terukazu Kawasaki, Yasuyuki Fukumaki

    J Hum Genet.   45 ( 3 )   127 - 132   2000.1

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    DOI: 10.1007/s100380050198

  • A high resolution PAC and BAC map of the SCA2 region. Reviewed International journal

    #Tamilla Nechiporuk, #Alex Nechiporuk, Soodabeh Sahba, Karla Figueroa, Hiroki Shibata, Xiao-Ning Chen, Julie R. Korenberg, Pieter de Jong, Stefan-M. Pulst

    Genomics   1997.9

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  • Molecular evolution of the 5'-flanking regions of the duplicated Amy genes in Drosophila melanogaster species subgroup. Reviewed International journal

    #Eisaku Okuyama, #Hiroki Shibata, Hidenori Tachida, Tsuneyuki Yamazaki

    Mol Biol Evol.   13 ( 4 )   574 - 583   1996.4

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  • Evolutionary relationship and sequence variation of a-amylase variants encoded by duplicated genes in the Amy locus of Drosophila melanogaster. Reviewed International journal

    #Nobuyuki Inomata, #Hiroki Shibata, #Eisaku Okuyama, Tsuneyuki Yamazaki

    Genetics   141 ( 1 )   237 - 244   1995.9

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    Repository Public URL: https://hdl.handle.net/2324/7177979

  • A comparative study of the enzymological features of a-amylase in the Drosophila melanogaster species subgroup. Reviewed International journal

    #Hiroki Shibata, Tsuneyuki Yamazaki

    Jpn J Genet.   69 ( 3 )   251 - 258   1994.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1266/jjg.69.251

    Repository Public URL: https://hdl.handle.net/2324/7177978

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Books

  • Venomics study of Protobothrops flavoviridis snake: Habu snake venomics: How venom proteins have evolved?

    Tomohisa Ogawa, Hiroki Shibata( Role: Joint author)

    IntechOpen  2020.4 

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    Language:English   Book type:Scholarly book

  • 毒ヘビ全書

    田原義太慶, 柴田弘紀, 友永達也( Role: Joint author)

    グラフィック社  2020.2 

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    Responsible for pages:ISBN 978-4-76613-313-4   Language:Japanese   Book type:General book, introductory book for general audience

  • 大蛇全書

    田原義太慶, 柴田弘紀, 友永達也( Role: Joint author)

    グラフィック社  2022.3 

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    Responsible for pages:ISBN 978-4766135589.   Language:Japanese   Book type:General book, introductory book for general audience

  • 大蛇全書

    田原 義太慶, 友永 達也, 柴田 弘紀

    グラフィック社  2022    ISBN:9784766135589

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    Language:Japanese  

    CiNii Books

  • Proteomic analysis of venomous fang matrix proteins of Protobothrops flavoviridis (Habu) snake. In: Endo K, Kogure T, Nagasawa H. (eds) Biomineralization: From Molecular and Nano-structural Analyses to Environmental Science.

    Tomohisa Ogawa, Asa Sekikawa, Hajime Sato, Koji Muramoto, Hiroki Shibata, Shosaku Hattori( Role: Joint author)

    Springer Nature, Singapore (2018).  2018.10 

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    Language:English   Book type:Scholarly book

  • ヒトは病気とともに進化した

    柴田 弘紀( Role: Joint author)

    勁草書房  2013.12 

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    Responsible for pages:ヒトは病気とともに進化した(長谷川真理子、太田博樹編)(「第七章: ヒトらしさの起源」の執筆を担当)   Language:Japanese   Book type:Scholarly book

  • 医学大辞典

    柴田弘紀( Role: Joint author)

    医学書院  2003.2 

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    Responsible for pages:医学大辞典 伊藤正男、井村裕夫、高久史麿 総編集 3項目   Language:Japanese   Book type:Scholarly book

  • 未知遺伝子多型の検索法

    柴田弘紀、服巻保幸( Role: Joint author)

    医薬ジャーナル社  2001.9 

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    Responsible for pages:薬物動態・作用と遺伝子多型 澤田康文他編、pp74-86   Language:Japanese   Book type:Scholarly book

  • 新女性医学体系第28巻 遺伝の基礎と臨床

    柴田弘紀、服巻保幸( Role: Joint author)

    中山書店  2000.5 

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    Responsible for pages:新女性医学体系第28巻 遺伝の基礎と臨床 DNA・遺伝子診断の基礎 PCR法大濱紘三編、pp81-89   Language:Japanese   Book type:Scholarly book

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Presentations

  • Ddhd1 knockout mouse as a model for familial spastic paraplegia. International conference

    #Takuya Morikawa, Hiroaki Ohishi, #Kengo Kosaka, #Tomofumi Shimojo, #Akihiro Nagano, Itsuki Taniguchi, @Ryuta Fujioka, @Kosei Moriyama, Motoko Unoki, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Hiroyuki Sasaki, @Shiroh Miura, Hiroki Shibata

    70th Annual Meeting of The American Society of Human Genetics  2020.10 

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    Event date: 2020.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • A nonsense variant in the ARSD gene associated with young-onset Parkinson’s disease. International conference

    2020.6 

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    Event date: 2020.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Berlin (virtual conference)   Country:Germany  

  • ハブベノミクス研究:多様な毒タンパク質は、どのように生み出されるのか?

    小川智久、上田直子、千々岩崇仁、佐藤矩行、柴田弘紀

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Ddhd1 knockout mice as a model for familial spastic paraplegia.

    Takuya Morikawa, Shiroh Miura, Hiroaki Ohishi, Kengo Kosaka, Tomofumi Shimojo, Akihiro Nagano, Ryuta Fujioka, Kosei Moriyama, Motoko Unoki, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Hiroyuki Sasaki, Hiroki Shibata

    2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Diversity and evolution of venom protein genes of a Japanese endemic pit viper, habu, Protobothrops flavoviridis. Invited International conference

    Hiroki Shibata

    The 1st NUS-FU-KU Joint Symposium on Biochemistry in FUKUOKA  2019.10 

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    Event date: 2019.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Habu snake (Protobothrops flavoviridis) genome study: Genomic architecture implicated in the multiplication and accelerated evolution of venom protein.v International conference

    Hiroki Shibata H, Naoko Oda-Ueda, Takahito Chijiwa, Hitomi Nakamura, Kazuaki Yamaguchi, Shosaku Hattori, Kazumi Matsubara, Yoichi Matsuda, Ryo Koyanagi, Yasuyuki Fukumaki, Motonori Ohno, Eiichi Shoguchi, Noriyuki Satoh, Tomohisa Ogawa

    EMBO/EMBL Symposium: Systems Genetics: From Genomes to Complex Traits  2019.9 

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    Event date: 2019.9 - 2019.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  • Identification of non-venom protein genes highly expressed in the venom gland of habu (Protobothrops flavoviridis) and their potential contribution to the quality control of venom proteins. International conference

    Akiko Isomoto, Kanako Hisata, Jun Inoue, Eiichi Shoguchi, Noriyuki Satoh, Tomohisa Ogawa, Hiroki Shibata

    20th World Congress of the International Society of Toxinology  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Argentina  

  • Genetic analysis of autosomal dominant motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough. International conference

    Shiroh Miura, Kengo Kosaka, Ryuta Fujioka, Takayuki Taniwaki, Hiroki Shibata

    The European Human Genetics Conference 2019  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Sweden  

  • Ddhd1 knockout mouse as a model for familial spastic paraplegia. International conference

    Takuya Morikawa, Shiroh Miura, Hiroaki Ohishi, Kengo Kosaka, Tomofumi Shimojo, Akihiro Nagano, Ryuta Fujioka, Kosei Moriyama, Motoko Unoki, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Hiroyuki Sasaki, Hiroki Shibata

    The European Human Genetics Conference 2019  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Sweden  

  • Whole genome sequencing of a Japanese endemic pit viper, habu, Protobothrops flavoviridis reveals accelerated evolution of venom protein genes enriched in microchromosomal regions. Invited International conference

    Hiroki Shibata

    2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  • ハブ(Protobothrops flavoviridis)の全ゲノム配列決定から明らかになった毒液関連遺伝子群の多重化および加速進化と染色体構造との関係.

    柴田弘紀, 千々岩崇仁, 小田-上田直子, 服部正策, 松原和純, 松田洋一, 山崎慎一, 藤江学, 後藤大輝, 小柳亮, 竹内猛, 服巻保幸, 大野素徳, 将口栄一, 久田香奈子, 佐藤矩行, 小川智久

    日本爬虫両棲類学会第57回大会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:麻布大学(相模原)   Country:Japan  

  • Exome sequencing in sporadic patients with young-onset parkinsonism reveals novel candidates. International conference

    Miura S, Shimojo T, Kosaka K, Fujioka R, Taniwaki T, Shibata H.

    2018 American Neurological Association Annual Meeting  2018.11 

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    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Whole genome sequencing of a Japanese endemic pit viper, habu, Protobothrops flavoviridis reveals accelerated evolution of venom protein genes enriched in microchromosomal regions. International conference

    Shibata H, Chijiwa T, Oda-Ueda N, Yamaguchi K, Hattori S, Matsubara K, Matsuda Y, Isomoto A, Koyanagi R, Hisata K, Fukumaki Y, Ohno M, Shoguchi E, Satoh N, Ogawa T.

    The International Society of Toxinology 2018 European Section Congress  2018.9 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Armenia  

  • Whole genome sequencing of a Japanese endemic pit viper, habu, Protobothrops flavoviridis reveals accelerated evolution of venom protein genes enriched in microchromosomal regions. International conference

    Shibata H, Chijiwa T, Oda-Ueda N, Yamaguchi K, Hattori S, Matsubara K, Matsuda Y, Koyanagi R, Hisata K, Fukumaki Y, Ohno M, Shoguchi E, Satoh N, Ogawa T.

    SMBE 2018  2018.7 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • A novel nonsense variant (Lys177X) of FGF14 in a Japanese patient with autosomal dominant spinocerebellar ataxia. International conference

    Miura S, Kosaka K, Fujioka R, Uchiyama Y, Taniwaki T, Shimojo T, Shibata H.

    The European Human Genetics Conference 2018  2018.6 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  • ハブゲノム解読により明らかになった毒関連遺伝子の進化.

    小川智久, 千々岩崇仁, 小田-上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森一樹, 田代康介, 久原哲, 山崎慎一, 藤江学, 後藤大輝, 小柳亮, 竹内猛, 服巻保幸, 大野素徳, 将口栄一. 久田香奈子, 佐藤矩行, 柴田弘紀

    第40回日本分子生物学会年会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • A novel missense variation (Q220R) of GNB4 encoding a guanine nucleotide-binding protein, beta-4 in a Japanese neuropathy family. International conference

    Shiroh Miura, Takuya Morikawa, Ryuta Fujioka, Kazuhito Noda, Kengo Kosaka, Takayuki Taniwaki, Hiroki Shibata

    The European Human Genetics Conference 2017  2017.5 

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    Event date: 2017.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Denmark  

  • Accelerated evolution of venom protein genes in the habu genome. International conference

    Hiroki Shibata

    Global Symposium GEM <Genome Evolution at Mishima>  2017.3 

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    Event date: 2017.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Habu snake genome reveals the evolutionary strategy for generating the venom-related genes. International conference

    Tomohisa Ogawa, Takahito Chijiwa, Naoko Oda-Ueda, Hitomi Nakamura, Shousaku Hattori, Kazumi Matsubara, Yoichi Matsuda, Kazuki Mori, Kosuke Tashiro, Shinichi Yamasaki, Manabu Fujie, Hiroki Goto, Ryo Koyanagi, Yasuyuki Fukumaki, Motonori Ohn, Eiichi Shoguchi, Kanako Hisata, Noriyuki Satoh, Hiroki Shibata

    Global Symposium GEM <Genome Evolution at Mishima>  2017.3 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ハブ(Protobothrops flavoviridis)の全ゲノム配列決定から明らかになった毒液関連遺伝子群の多重化と加速進化および染色体構造との関係

    柴田弘紀, 千々岩崇仁, 上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森 一樹, 田代 康介, 久原 哲, 山崎慎一, 藤江学, 後藤大輝, 将口栄一, 久田香奈子, 小柳亮, 佐藤矩行, 大野素徳, 服巻保幸

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜、パシフィコ横浜   Country:Japan  

  • 脊髄小脳変性症に関わる新規責任遺伝子の同定

    森川拓弥, 三浦史郎, 小坂健悟, 藤岡竜太, 佐野 謙, 頼田章子, 内山雄介, 谷脇考恭, 柴田弘紀

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜、パシフィコ横浜   Country:Japan  

  • ハブ(Protobothrops flavoviridis)の全ゲノム配列決定から明らかになった毒液関連遺伝子群の多重化と加速進化および染色体構造との関係

    柴田弘紀, 千々岩崇仁, 上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森 一樹, 田代 康介, 久原 哲, 山崎慎一, 藤江学, 後藤大輝, 将口栄一, 久田香奈子, 小柳亮, 佐藤矩行, 大野素徳, 服巻保幸

    第55回日本爬虫両棲類学会大会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:琉球大学   Country:Japan  

  • Heterozygous missense mutation in SEC24A encoding a coat protein complex II vesicle associated with autosomal dominant spinocerebellar ataxia. International conference

    Takuya Morikawa, Shiroh Miura, Kengo Kosaka, Ryuta Fujioka, Ken Sano, Akiko Yorita, Kosuke Aoki, Yusuke Uchiyama, Takayuki Taniwaki, Hiroki Shibata

    66th Annual Meeting of The American Society of Human Genetics  2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • A missense mutation in the PPIG gene encoding the peptidyl-prolyl isomerase G in patients with autosomal dominant benign adult familial myoclonic epilepsy. International conference

    Ryuta Fujioka, Shiroh Miura, Kohei Yamada, Takuya Morikawa, Hiromichi Motooka, Yasuhiro Aso, Noriyuki Kimura, Ken Sano, Ken Yamamoto, Takayuki Taniwaki, Hiroki Shibata

    66th Annual Meeting of The American Society of Human Genetics  2016.10 

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    Event date: 2016.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • 毒蛇ハブ(Protobothrops flavoviridis)の全ゲノム配列決定から明らかになった毒液関連遺伝子群の多重化と染色体構造との関係

    柴田弘紀, 千々岩崇仁, 上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森 一樹, 田代 康介, 久原 哲, 山崎慎一, 藤江学, 後藤大輝, 将口栄一, 久田香奈子, 小柳亮, 佐藤矩行, 大野素徳, 服巻保幸

    第89回日本生化学会大会  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台国際センター   Country:Japan  

  • SPG28の発症に関わるDDHD1内の新規ホモ接合変異の同定

    森川拓弥, 三浦史郎, 藤岡竜太, 小坂健悟, 山田浩平, 服部剛典, 本村学, 谷脇考恭, 柴田弘紀

    日本遺伝学会第88回大会  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学国際関係学部北口校舎、三島、静岡   Country:Japan  

  • 連鎖解析とエクソームシーケンスによる新規ニューロパチー家系の疾患責任遺伝子変異の同定

    小坂健悟, 三浦史郎, 佐野謙, 藤岡竜太, 才津浩智, 谷脇考恭, 山本健, 柴田弘紀

    日本遺伝学会第88回大会  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本大学国際関係学部北口校舎、三島、静岡   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノム配列決定と遺伝子モデルの作製

    柴田弘紀, 千々岩崇仁, 上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森 一樹, 田代 康介, 久原 哲, 山崎慎一, 藤江学, 後藤大輝, 将口栄一, 久田香奈子, 小柳亮, 佐藤矩行, 大野素徳, Yasuyuki Fukumaki

    第63回トキシンシンポジウム  2016.7 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ほほえみの宿 滝の湯、天童   Country:Japan  

  • Homozygous 4-bp deletion in the DDHD1 gene, resulting the complete deletion of DDHD domain, as a causative variant in a SPG28 patient.

    The 13th International Congress of Human Genetics  2016.4 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノム配列決定と遺伝子モデルの作製

    柴田弘紀, 千々岩崇仁, 上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森 一樹, 田代 康介, 久原 哲, 山崎慎一, 藤江学, 後藤大輝, 将口栄一, 久田香奈子, 小柳亮, 佐藤矩行, 大野素徳, Yasuyuki Fukumaki

    第54回日本爬虫両棲類学会大会  2015.12 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東邦大学習志野キャンパス   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノム配列決定と遺伝子モデルの作製

    柴田弘紀, 千々岩崇仁, 上田直子, 中村仁美, 服部正策, 松原和純, 松田洋一, 森 一樹, 田代 康介, 久原 哲, 山崎慎一, 藤江学, 後藤大輝, 将口栄一, 久田香奈子, 小柳亮, 佐藤矩行, 大野素徳, Yasuyuki Fukumaki

    第38回日本分子生物学会年会、第88回日本生化学会大会合同大会  2015.12 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノム配列決定と遺伝子モデルの作製

    柴田弘紀, 千々岩崇仁, 上田直子, 服部正策, 小柳亮, 久田香奈子, 佐藤矩行, 大野素徳, Yasuyuki Fukumaki, 小川智久

    第87回日本遺伝学会大会  2015.9 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東北大学   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノムシークエンスと繰り返し配列の解析

    柴田弘紀, 山本真由美, タケット奈々, 小川智久, 森一樹, 千々岩崇仁, 服部正策, 上田直子, 久原 哲, 大野素徳, 服巻保幸

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノムシークエンスと繰り返し配列の解析

    柴田弘紀, 山本真由美, タケット奈々, 小川智久, 森一樹, 千々岩崇仁, 服部正策, 上田直子, 久原 哲, 大野素徳, 服巻保幸

    日本爬虫両棲類学会第52回大会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノムシークエンスと繰り返し配列の解析

    柴田弘紀, 山本真由美, タケット奈々, 小川智久, 森一樹, 千々岩崇仁, 服部正策, 上田直子, 久原 哲, 大野素徳, 服巻保幸

    第85回日本遺伝学会大会  2013.9 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日吉   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の全ゲノムシークエンスと繰り返し配列の解析

    柴田弘紀, 山本真由美, タケット奈々, 小川智久, 森一樹, 千々岩崇仁, 服部正策, 上田直子, 久原 哲, 大野素徳, 服巻保幸

    第15回日本進化学会大会  2013.8 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  • Linkage-Exome approach to identify the responsible variant for a novel type of hereditary neuropathy

    2012.12 

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    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Genetic divergence of mitochondria genome sequence among island populations of Japanese Habu snakes, Protobothrops.

    2012.12 

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    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 連鎖・エクソームアプローチによる新規家族性ニューロパチーの変異検索

    藤原敏弥, 柴田 弘紀, 三浦史郎, 山本真由美, 貴田浩志, 野田和人, 加來庸一郎, 岩城 明子, 綾部光芳, 谷脇考恭, 服巻 保幸

    第84回日本遺伝学会大会  2012.9 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Linkage-assisted exome sequencing to identify the responsible variant for a novel type of hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities found in a single Japanese family. International conference

    Shibata H, Miura S, Kida H, Noda K, Kaku Y, Iwaki A, Ayabe M, Taniwaki T, Fukumaki Y.

    Human Genome Meeting 2012  2012.3 

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    Event date: 2012.3

    Presentation type:Oral presentation (general)  

    Country:Australia  

  • Exome sequencing approach to identify the responsible variant for a novel type of hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities found in a Japanese descent. International conference

    Shibata H, Miura S, Kida H, Noda K, Kaku Y, Iwaki A, Ayabe M, Taniwaki T, Fukumaki Y.

    12th International Congress of Human Genetics / 61st Annual Meeting of The American Society of Human Genetics, Montreal, Canada  2011.10 

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    Event date: 2011.10

    Presentation type:Oral presentation (general)  

    Country:Canada  

  • Resequencing of dopamine receptor genes DRD1 and DRD2 as schizophrenia susceptibility genes revealed non-neutral process possibly associated with schizophrenia.

    Yu Liang, Yasuyuki Fukumaki, Hiroki Shibata

    2010.12 

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    Event date: 2010.12

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Resequencing of the catechol-O-methyltransferase gene, COMT revealed non-neutral processes associated with schizophrenia. International conference

    Hiroki Shibata, Maiko Uchida, Hiroki Goto, Shuhei Mano, Osamu Takenaka, Yasuyuki Fukumaki

    60th Annual Meeting of The American Society of Human Genetics  2010.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Country:United States  

  • 統合失調症感受性遺伝子COMTに見出される中立進化からの逸脱

    柴田弘紀、内田麻衣子、後藤大輝、間野修平、竹中 修、服巻保幸

    日本人類遺伝学会第55回大会  2010.10 

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    Event date: 2010.10

    Presentation type:Oral presentation (general)  

    Venue:さいたま   Country:Japan  

  • 統合失調症関連候補遺伝子としてのPCP応答遺伝子探索と関連解析

    鄧 湘東、柴田弘紀、高木宏美、王 麗香、黒木俊秀、中原 辰雄、橋本喜次郎、岩田仲生、尾崎紀夫、有波忠雄、服巻保幸

    日本人類遺伝学会第55回大会  2010.10 

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    Event date: 2010.10

    Presentation type:Oral presentation (general)  

    Venue:さいたま   Country:Japan  

  • 統合失調症感受性遺伝子COMTに見出される中立進化からの逸脱

    柴田弘紀、内田麻衣子、後藤大輝、間野修平、竹中 修、服巻保幸

    第82回日本遺伝学会大会  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • 統合失調症の原因を進化的手法で探る〜天才とナントカは紙一重か?〜

    柴田弘紀

    第12回日本進化学会大会  2010.8 

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    Event date: 2010.8

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific balancing selection in GRIN2B upstream region. International conference

    Hiroki Shibata, Kunika Tanaka, Kazunori Watanabe, Hiroki Goto, Shuhei Mano, Osamu Takenaka, Yasuyuki Fukumaki.

    International Symposium on Biodiversity Sciences: Genome, Evolution and Environment  2010.7 

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    Event date: 2010.7 - 2010.8

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 統合失調症感受性遺伝子としてのグルタミン酸受容体遺伝子群の集団遺伝学手法による自然選択の検出

    柴田弘紀、田中邦佳、渡邉和典、後藤大輝、間野修平、竹中 修、服巻保幸

    第5回日本統合失調症学会  2010.3 

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    Event date: 2010.3

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • マイクロサテライトマーカーを用いた統合失調症のゲノムワイド関連解析

    服巻保幸、山本 健、岡 晃、猪子英俊、有波忠雄、岩田仲生、尾崎紀夫、柴田弘紀

    第5回日本統合失調症学会  2010.3 

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    Event date: 2010.3

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 統合失調症感受性遺伝子としてのCOMT遺伝子の分子進化学的解析

    内田麻衣子、服巻保幸、柴田弘紀

    第32回日本分子生物学会年会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific balancing selection in the GRIN2B upstream region. International conference

    Hiroki Shibata, Kazunori Watanabe, Kunika Tanaka, Hiroki Goto, Shuhei Mano, Osamu Takenaka, Yasuyuki Fukumaki.

    59th Annual Meeting of The American Society of Human Genetics  2009.10 

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    Event date: 2009.10

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Genome-wide association study of schizophrenia using STR markers. International conference

    Yasuyuki Fukumaki Y, Ken Yamamoto, Zhu Sun, Akira Oka, Hidetoshi Inoko, Tadao Arinami, Nakao Iwata, Norio Ozaki, Hiroki Shibata.

    59th Annual Meeting of The American Society of Human Genetics  2009.10 

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    Event date: 2009.10

    Presentation type:Oral presentation (general)  

    Country:United States  

  • 高次脳機能関連遺伝子群の分子進化学的解析:代謝調節型グルタミン酸受容体遺伝子群における自然選択の検出

    柴田弘紀、森田 彩、後藤大輝、間野修平、竹中 修、服巻保幸

    日本人類遺伝学会第54回大会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 統合失調症のSTRマーカーによるゲノムワイド関連解析

    服巻保幸、山本 健、孫 竹、岡 晃、猪子英俊、有波忠雄、岩田仲生、尾崎紀夫、柴田弘紀

    日本人類遺伝学会第54回大会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 高次脳機能関連遺伝子群の分子進化学的解析:代謝調節型グルタミン酸受容体遺伝子群における自然選択の検出

    柴田弘紀、森田 彩、後藤大輝、間野修平、竹中 修、服巻保幸

    第81回日本遺伝学会大会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:松本   Country:Japan  

  • 高次脳機能関連遺伝子群の分子進化学的解析:代謝調節型グルタミン酸受容体遺伝子群における自然選択の検出

    柴田弘紀、森田 彩、後藤大輝、間野修平、竹中 修、服巻保幸

    第11回日本進化学会大会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • Molecular Evolutionary Study Of The Ionotropic Glutamate-Receptor Gene Family As Schizophrenia Susceptibility Genes: Human-Specific Balancing Selection In GRIN2B Upstream Region International conference

    Hiroki Shibata, Kunika Tanaka K, Kazunori Watanabe, Hiroki Goto, Shuhei Mano, Osamu Takenaka, Yasuyuki Fukumaki.

    The 8th International Workshop on Advanced Genomics: Expansion of Genome Science, Tokyo, Japan.  2009.6 

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    Event date: 2009.6

    Country:Japan  

    Molecular Evolutionary Study Of The Ionotropic Glutamate-Receptor Gene Family As Schizophrenia Susceptibility Genes: Human-Specific Balancing Selection In GRIN2B Upstream Region

  • Comparative analysis of glutamate receptor gene family between human and chimpanzee

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Association study of phencyclidine-responsive genes with schizophrenia International conference

    Xiangdong Deng, Hiroki Shibata, Toshihide Kuroki, Tatsuo Nakahara, Kijiro Hashimoto, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

    58th Annual Meeting of The American Society of Human Genetics  2008.11 

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    Event date: 2008.11

    Country:United States  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific non-neutral pattern observed in GRIN2B upstream region. International conference

    Hiroki Shibata, Kunika Tanaka, Kazunori Watanabe, Hiroki Goto, Shuhei Mano, Osamu Takenaka, Yasuyuki Fukumaki.

    XX International Congress of Genetics  2008.10 

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    Event date: 2008.10

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Search for schizophrenia susceptibility loci focusing on PCP-responsive genes as candidates. International conference

    Yasuyuki Fukumaki, Xiangdong Deng, Toshihide Kuroki, Tatsuo Nakahara, Kijiro Hashimoto, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Hiroki Shibata .

    XX International Congress of Genetics  2008.10 

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    Event date: 2008.10

    Country:Japan  

  • 統合失調症感受性遺伝子としてのグルタミン酸受容体遺伝子群の分子進化学的解析 II

    柴田弘紀、渡邉和典、田中邦佳、森田 彩、後藤大輝 、間野修平、竹中 修、服巻保幸

    日本人類遺伝学会第53回大会  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 高次脳機能に関連するイオンチャンネル型グルタミン酸受容体遺伝子群14種の上流調節領域における分子進化学的解析

    柴田弘紀、渡邉和典、田中邦佳、森田 彩、後藤大輝 、間野修平、竹中 修、服巻保幸

    第80回日本遺伝学会大会  2008.9 

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    Event date: 2008.9

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 統合失調症関連遺伝子としてのグルタミン酸受容体遺伝子群の分子進化学的解析

    柴田弘紀

    第10回日本進化学会大会  2008.8 

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    Event date: 2008.8

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific non-neutral pattern observed in GRIN2B upstream region International conference

    Hiroki Shibata, Kunika Tanaka, Kazunori Watanabe, Hiroki Goto, Shuhei Mano, Osamu Takenaka, Yasuyuki Fukumaki.

    XX International Congress of Genetics  2008.7 

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    Event date: 2008.7

    Country:Germany  

  • 進化医学序説:なぜ病気は存在するのか?

    服巻保幸、小林 茂、柴田弘紀

    第30回日本分子生物学会年会、第80回日本生化学会大会合同大会  2007.12 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • グルタミン酸受容体遺伝子群におけるヒト特異的アミノ酸置換の同定と上流領域の分子進化学的解析

    田中邦佳、渡邉和典、蔭山瑠衣、後藤大輝、蘭 直純、黒木陽子、豊田 敦、服部正平、榊 佳之、藤山秋佐夫、服巻保幸、柴田弘紀

    分子生物学会2006フォーラム  2006.12 

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    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  • 統合失調症感受性遺伝子としてのグルタミン酸受容体遺伝子群の分子進化学的解析

    柴田弘紀、田中邦佳、渡邉和典、蔭山瑠衣、後藤大輝、蘭 直純、黒木陽子、豊田 敦、服部正平、榊 佳之、藤山秋佐夫、服巻保幸

    第52回日本人類遺伝学会、  2007.9 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 統合失調症関連遺伝子としてのグルタミン酸受容体遺伝子群の分子進化学的解析

    柴田弘紀、田中邦佳、渡邉和典、後藤大輝、竹中 修、服巻保幸

    日本遺伝学会第79回大会  2007.9 

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    Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  • 統合失調症関連遺伝子としてのグルタミン酸受容体遺伝子群の分子進化学的解析 Invited

    柴田弘紀

    国立遺伝学研究所研究会シンポジウム「ヒトゲノム多様性に基づく進化医学の発展」  2007.10 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:国立遺伝学研究所、三島   Country:Japan  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific non-neutral pattern observed in GRIN2B upstream region. International conference

    Shibata H, Tanaka K, Watanabe K, Goto H, Takenaka O, Fukumaki Y.

    57th Annual Meeting of The American Society of Human Genetics  2007.10 

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    Country:Japan  

  • ベノミクス研究により明らかになった毒蛇ハブの新規毒成分の機能と毒関連特殊機能の進化

    小川 智久, 柴田 弘紀, 上田 直子, 佐藤 矩行, 服部 正策, 日高 將文, 二井 勇人

    第96回日本生化学会大会  2023.11 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場、マリンメッセ福岡   Country:Japan  

  • 毒蛇ハブのゲノム解析で明らかになった毒液タンパク質遺伝子の進化 Invited

    柴田 弘紀, 上田 直子, 千々岩 崇仁, 中村 仁美, 服部 正策, 服巻 保幸, 大野 素徳, 佐藤 矩行, 小川 智久

    第96回日本生化学会大会  2023.11 

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    Event date: 2023.10 - 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場、マリンメッセ福岡   Country:Japan  

  • ハブ毒腺トランスクリプトミクスおよび全ゲノム配列の集団間比較解析

    #孫 崟瑞, #汪 趙楠, 小川 智久, 柴田 弘紀

    東京大学医科学研究所 奄美病害動物研究施設 第3棟改築記念シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:アマホーム PLAZA (奄美市市民交流センター)   Country:Japan  

  • 毒蛇ハブのゲノム解析で明らかになった毒タンパク質遺伝子の進化 Invited

    柴田 弘紀

    東京大学医科学研究所 奄美病害動物研究施設 第3棟改築記念シンポジウム  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:アマホーム PLAZA (奄美市市民交流センター)   Country:Japan  

  • ハブ毒腺トランスクリプトミクスの集団間比較解析

    #孫 崟瑞, #汪 趙楠, 小川 智久, 柴田 弘紀

    第69回トキシンシンポジウム  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都産業大学   Country:Japan  

  • ヒメハブ血清中に含まれる毒中和因子 Small serum protein:SSP 遺伝子アレイの島間比較による進化過程の考察

    矢内翔貴, 原尾朔弥, 竹内亜美, 前田真理恵, 柴田弘紀, 服部正策, 小田-上田直子, 千々岩崇仁

    第69回トキシンシンポジウム  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都産業大学   Country:Japan  

  • 先天性白内障を伴う痙性対麻痺家系における責任遺伝子変異の探索

    #渡邊 笑奈、三浦 史郎、#比留木 成美、#孫 崟瑞、柴田 弘紀

    日本遺伝学会第95回大会  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本大学   Country:Japan  

  • Familial retinitis pigmentosa with neuromuscular symptoms carrying a novel nonsense variant in RDH11. International conference

    #Shigeyoshi Hiruki, Shiroh Miura, Saho Fujishita, Hiroki Shibata

    XXIII International Congress of Genetics  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 毒蛇ハブのゲノム解析で明らかになった毒液遺伝子の進化 Invited

    柴田弘紀

    令和5年度 日本環境変異原ゲノム学会 公開シンポジウム「有毒生物と遺伝子変異〜遺伝子変異のメカニズム〜」  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:慶應大学薬学部   Country:Japan  

  • 孤発性young-onset Parkinson's diseaseの遺伝解析

    三浦史郎, #渡邊笑奈, #比留木成美, 森川拓弥, 内山雄介, 柴田弘紀

    第64回日本神経学会学術大会  2023.6 

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    Event date: 2023.5 - 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張メッセ   Country:Japan  

  • RDH11の新規ナンセンス変異を持つ神経および筋肉症状を併発する家族性網膜色素変性症

    #比留木成美, 三浦史郎, 藤下幸穂, 柴田弘紀

    第46回日本分子生物学会年会  2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場   Country:Japan  

  • RNA-seq of induced-neuronal cells revealed abnormal splicing of IQGAP3 in motor and sensory neuropathy.

    #Luoming Fan, Noriaki Sagata, Takahiro A. Kato, Shiroh Miura, Hiroki Shibata

    2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ハブ毒腺トランスクリプトミクスおよび全ゲノム配列の集団間比較解析

    #孫 崟瑞, #汪 趙楠, 小川 智久, 柴田 弘紀

    第46回日本分子生物学会年会  2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場   Country:Japan  

  • 比較ゲノミクスとタンパク質構造予測から推定されたヘビSmall Serum Proteins(SSPs)の進化

    竹林聖純, 磯本明子, 日高將文, 二井勇人, 柴田弘紀, 小川智久

    第45回日本分子生物学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張メッセ   Country:Japan  

  • 常染色体優性運動神経障害および感覚神経障害におけるグアニンヌクレオチド交換因子の異常な過剰発現

    #範 駱鳴, #孫 崟瑞, 藤岡 ⻯太, 三浦 史郎, 柴田 弘紀

    第45回日本分子生物学会年会  2022.12 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張メッセ   Country:Japan  

  • 沖縄島におけるサキシマハブ,タイワンハブ,在来種ハブの交雑状況の遺伝学的調査

    富永 篤, 寺田考紀, 嘉陽翔太, 上江洲安史, 柴田弘紀, 戸田 守, 岡 慎一郎, 太田英利

    日本爬虫両棲類学会第61回大会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:琉球大学   Country:Japan  

  • 常染色体優性遺伝性運動および感覚神経障害に関連するIQGAP3のイントロン変異の機能分析

    #範 駱鳴, #孫 崟瑞, 森川拓弥, 藤岡竜太, 三浦史郎, 柴田弘紀

    日本遺伝学会第94回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学   Country:Japan  

  • エクソーム解析を用いた若年発症パーキンソン病の責任変異の探索

    #渡邊笑奈, 三浦史郎, 柴田弘紀, 内山雄介

    日本遺伝学会第94回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学   Country:Japan  

  • 全ゲノムデータからの日本産ハブ属4集団の集団動態解析

    #孫 崟瑞, 柴田弘紀

    日本遺伝学会第94回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学   Country:Japan  

  • RDH11の新規ナンセンス変異を持つ神経および筋肉症状を併発する家族性網膜色素変性症

    #比留木成美, 三浦史郎, 藤下幸穂, 柴田弘紀

    日本遺伝学会第94回大会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学   Country:Japan  

  • ヒメハブ血清に含まれる毒中和因子:SSPをコードする遺伝子アレイのゲノム構造解析

    #矢内翔貴, #原尾朔弥, #竹内亜美, #前田真理恵, 柴田弘紀, 服部正策, 小田-上田直子, 千々岩崇仁

    第68回トキシンシンポジウム  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 比較ゲノミクスとタンパク質構造予測から推定されたヘビSmall Serum Proteins(SSPs)の進化

    @稲丸賢人, @竹内亜美, @前田真理恵, 柴田弘紀, 服巻保幸, @上田直子, @服部正策, 大野素徳, @千々岩崇仁

    第44回日本分子生物学会年会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜   Country:Japan  

  • A novel 1-bp deletion variant in DAG1 in Japanese familial idiopathic hyper CK-emia

    #Luoming Fan, @Shiroh Miura, #Tomofumi Shimojo, @Hirotoshi Sugino, @Ryuta Fujioka, Hiroki Shibata

    2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 人工抗毒素産生系開発に向けた抗毒素のレパトア解析

    #孫 崟瑞, #範 駱鳴, @小川 智久, 柴田 弘紀

    第67回トキシンシンポジウム  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 南西諸島14島からの109個体を用いたハブの集団構造解析

    #比留木成美, 手島康介, @寺田考紀, @服部正策, 柴田 弘紀

    日本遺伝学会第93回大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 波紋筋病(Rippling muscle disease)家系の遺伝解析

    #範 駱鳴, #青木 浩介, #永野 明宏, @荒畑 創, @古谷 博和, 柴田 弘紀

    日本遺伝学会第93回大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • Functional analysis of IQGAP3 as a causative gene of autosomal dominant hereditary motor and sensory neuropathy

    #Luoming Fan, #Kengo Kosaka, #Akihiro Nagano, #Tomofumi Shimojo, #Takuya Morikawa, @Ryuta Fujioka, @Shiroh Miura, Hiroki Shibata

    2020.12 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Ddhd1 knockout mouse as a model for familial spastic paraplegia

    #Takuya Morikawa, @Shiroh Miura, Hiroaki Ohishi, #Kengo Kosaka, #Tomofumi Shimojo, #Akihiro Nagano, Itsuki Taniguchi, @Ryuta Fujioka, @Kosei Moriyama, Motoko Unoki ,Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Hiroyuki Sasaki, Hiroki Shibata

    2020.12 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Functional analysis of a TDRKH variant associated with autosomal dominant motor neuropathy

    #Luoming Fan, #Akihiro Nagano, #Kengo Kosaka, #Tomofumi Shimojo, #Takuya Morikawa, @Ryuta Fujioka, @Shiroh Miura, Hiroki Shibata

    2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 痙性対麻痺28型の発症メカニズムの解明とバイオマーカー探索

    #森川拓弥, @三浦史郎, #大石裕晃, #小坂健悟, #下條智史, #永野明宏, 谷口愛樹, @藤岡竜太, @森山耕成, 鵜木元香, 高橋政友, 中尾素直, 和泉自泰, 馬場健史, 佐々木裕之, 柴田弘紀

    日本遺伝学会第92回大会  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  • 常染色体優性遺伝性運動性ニューロパチー家系で同定したTDRKH変異の機能解析

    永野明宏、小坂健悟、三浦史郎、下條智文、長田周治、森川拓弥、藤岡竜太、野村拓夫、谷脇考恭、柴田弘紀

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 新規ニューロパチー家系で同定した新規IQGAP3内変異の遺伝学的解析

    下條 智史, 三浦 史郎, 小坂 健悟, 松浦 英治, 野田 和人, 藤岡 竜太, 森 慎一郎, 梅原 藤雄, 岩城 徹, 山本 健, 才津 浩智, 柴田 弘紀

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 家族性痙性対麻痺のモデルであるDdhd1ノックアウトマウスの解析

    森川拓弥、三浦史郎、大石裕晃、小坂健悟、下條智史、永野明宏、藤岡竜太、森山耕成、鵜木元香、高橋政友、中尾素直、和泉自泰、馬場健史、佐々木裕之、柴田弘紀

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ホンハブのSSP遺伝子アレイの決定と獲得過程

    稲丸 賢人、竹内 亜美、前田真理恵、柴田 弘紀、服巻 保幸、上田 直子、服部 正策、大野 素徳、千々岩 崇仁

    第42回日本分子生物学会年会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • ホンハブのSSP遺伝子アレイの決定と獲得過程

    稲丸 賢人、竹内 亜美、前田真理恵、柴田 弘紀、服巻 保幸、上田 直子、服部 正策、大野 素徳、千々岩 崇仁

    日本爬虫両棲類学会第58回大会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山理科大学、岡山   Country:Japan  

  • Genetic analysis of autosomal dominant paroxysmal kinesigenic dyskinesia (PKD).

    Tomofumi Shimojo, Shiroh Miura, Kengo Kosaka, Takuya Morikawa, Kosuke Aoki, Takashi Kamada, Hiroki Shibata

    2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Genetic analysis of autosomal dominant paroxysmal kinesigenic dyskinesia (PKD). International conference

    Tomofumi Shimojo, Shiroh Miura, Kengo Kosaka, Takuya Morikawa, Kosuke Aoki, Takashi Kamada, Hiroki Shibata

    69th Annual Meeting of The American Society of Human Genetics,  2019.10 

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    Event date: 2019.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Exome sequencing in familial paroxysmal kinesigenic dyskinesia reveals novel candidates International conference

    Shiroh Miura, Tomofumi Shimojo, Takashi Kamada, Hiroki Shibata

    2019 American Neurological Association Annual Meeting  2019.10 

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    Event date: 2019.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 新規ニューロパチー家系で同定した新規IQGAP3内変異の遺伝学的解析.

    下條智史, 三浦史郎, 小坂健悟, 佐野謙, 藤岡竜太, 才津浩智, 谷脇孝恭, 山本健, 柴田弘紀

    日本遺伝学会第91回大会  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  • 家族性痙性対麻痺のモデルであるDdhd1ノックアウトマウスの解析.

    #森川拓弥, @三浦史郎, #大石裕晃, #小坂健悟, #下條智史, #永野明宏, @藤岡竜太, @森山耕成, 鵜木元香, 高橋政友, 中尾素直, 和泉自泰, 馬場健史, 佐々木裕之, 柴田弘紀

    日本遺伝学会第91回大会  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  • The association study between HLA genotype and mucosal microbial composition in patients with inflammatory bowel diseases. International conference

    Hirano A, Shibata H, Kakuta Y, Nagasaki M, Tokunaga K, Khor SS, Kawai Y, Umeno J, Torisu T, Kitazono T, Esaki M.

    2019.2 

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    Event date: 2019.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • ホンハブのSmall Serum Protein(SSP)遺伝子アレイの特異な構造と進化.

    稲丸賢人, 千々岩崇仁, 竹内亜美, 前田真理恵, 山口和晃, 柴田弘紀, 服部正策, 上田直子, 大野素徳.

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜(横浜)   Country:Japan  

  • 脊髄小脳失調症27型で同定したFGF14内の新規ナンセンス変異.

    小坂健悟, 三浦史郎, 下條智史, 森川拓弥, 内山雄介, 谷脇考恭, 柴田弘紀.

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜(横浜)   Country:Japan  

  • 常染色体優性遺伝発作性運動誘発性ジスキネシア家系で同定したFAT2内の新規非同義変異.

    下條智史, 三浦史郎, 小坂健悟, 青木浩介, 鎌田崇嗣, 柴田弘紀.

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜(横浜)   Country:Japan  

  • CRISPR/Cas9によって作成したDdhd1ノックアウトマウスの解析.

    森川拓弥, 三浦史郎, 大石裕晃, 小坂健悟, 下條智史, 永野明宏, 鵜木元香, 佐々木裕之, 柴田弘紀.

    第41回日本分子生物学会年会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜(横浜)   Country:Japan  

  • 伊川津・縄文人ゲノムからみた東アジア人類集団の形成史.

    覚張隆史, 中込滋樹, Martin Sikora, Simon Rasmussen, Morten Allentoft, 佐藤丈寛, Thorfinn Korneliussen, Blánaid Ní Chuinneagáin, 松前ひろみ, 小金渕佳江, Ryan Schmidt, 茂原信生, 米田穣, 木村亮介, 石田肇, 増山禎之, 山田康弘, 田嶋敦, 柴田弘紀, 豊田敦, 埴原恒彦, Eske Willerslev, 太田博樹.

    第72回日本人類学会大会  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立遺伝学研究所(三島)   Country:Japan  

  • 脊髄小脳失調症27型で同定したFGF14内の新規ナンセンス変異.

    小坂健悟, 三浦史郎, 下條智史, 森川拓弥, 内山雄介, 谷脇考恭, 柴田弘紀

    日本人類遺伝学会第63回大会  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜(横浜)   Country:Japan  

  • 孤発性パーキンソン病における責任遺伝子の探索.

    下條智史, 三浦史郎, 小坂健悟, 森川拓弥, 谷脇考恭, 柴田弘紀.

    日本人類遺伝学会第63回大会  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜(横浜)   Country:Japan  

  • エクソーム解析によってFGF14内に新規ナンセンス変異を認めた脊髄小脳失調症27型の一例.

    小坂健悟, 三浦史郎, 下條智史, 森川拓弥, 内山雄介, 谷脇考恭, 柴田弘紀.

    日本遺伝学会第90回大会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良先端科学技術大学院大学(奈良)   Country:Japan  

  • DDHD1内の新規変異の同定とノックアウトマウスの作製.

    森川拓弥, 三浦史郎, 小坂健悟, 下條智文, 永野明宏, 柴田弘紀.

    日本遺伝学会第90回大会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良先端科学技術大学院大学(奈良)   Country:Japan  

  • 常染色体優性遺伝発作性運動誘発性ジスキネシア家系における責任遺伝子の探索.

    下條智史, 三浦史郎, 青木浩介, 谷脇孝恭, 柴田弘紀.

    日本遺伝学会第90回大会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良先端科学技術大学院大学(奈良)   Country:Japan  

  • A new targeted enrichment method, “BAC-double capture,” for ancient DNA analysis. International conference

    2018.9 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Jena   Country:Germany  

  • A new targeted-capture method using bacterial artificial chromosome (BAC) as baits exclusively developed for sequencing relatively large loci of ancient DNA. International conference

    Koganebuchi K, Gakuhari T, Takeshima H, Kasagi S, Sato T, Tajima A, Shibata H, Ogawa M, Oota H.

    SMBE 2018  2018.7 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Whole genome analysis of the Jomon remain reveals deep lineage of East Eurasian populations. International conference

    Gakuhari T, Sikora M, Rasmussen S, Allentoft M, Sato T, Korneliussen T, Matsumae M, Shigehara N, Yoneda M, Ishida H, Masuda Y, Yamada Y, Tajima A, Shibata H, Toyoda A, Hanihara T, Nakagome S, Willerslev E, Oota H.

    SMBE 2018  2018.7 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 遺伝学的に新規と考えられる常染色体優性遺伝性遠位型運動ニューロパチー.

    三浦史郎, 小坂健悟, 長田周治, 野村拓夫, 藤岡竜太, 下條智史, 谷脇考恭, 柴田弘紀.

    第59回日本神経学会学術大会  2018.5 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ロイトン札幌(札幌)   Country:Japan  

  • ハブゲノム解読から見出された新規Three-finger toxinsの発現と機能解析.

    土生津光, 齋藤浩唯, 柴田弘紀, 大野素徳, 服部正策, 松井崇, 田中良和, 村本光二, 小川智久

    第40回日本分子生物学会年会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • 常染色体優性遺伝運動性ニューロパチー家系で同定したTDRKH内の新規非同義変異.

    小坂健悟, 三浦史郎, 下條智史, 長田周治, 森川拓弥, 藤岡竜太, 野村拓夫, 谷脇考恭, 柴田弘紀

    第40回日本分子生物学会年会・第90回日本生化学会大会 合同年次大会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • DDHD1の新規責任変異の同定とCRISPR/Cas9によるDdhd1ノックアウトマウスの作成.

    森川拓弥, 三浦史郎, 大石裕晃, 藤岡竜太, 森山耕成, 小坂健悟, 下條智史, 柴田弘紀

    第40回日本分子生物学会年会・第90回日本生化学会大会 合同年次大会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • エクソーム解析及び連鎖解析を用いたRippling muscle disease (RMD)における新規責任遺伝子変異の同定.

    青木浩介, 荒畑創, 古谷博和, 柴田弘紀

    第40回日本分子生物学会年会・第90回日本生化学会大会 合同年次大会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • SSPをコードする新規遺伝子の発見とSSP遺伝子の獲得過程の考察.

    稲丸賢人, 千々岩崇仁, 柴田弘紀, 服巻保幸, 服部正策, 大野素徳

    第40回日本分子生物学会年会・第90回日本生化学会大会 合同年次大会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • 「岩国のシロヘビ」アルビノ変異原因遺伝子の同定.

    岩西修造, 財津将平, 柴田弘紀, 仁田坂英二

    第40回日本分子生物学会年会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • 末梢血におけるKLF14遺伝子領域のDNAメチル化は2型糖尿病の発症を予測しうる.

    岩谷千寿, 柴田弘紀, 山本健, 北島秀俊, 前田泰孝, 園田紀之, 小川佳宏, 井口登與志

    第40回日本分子生物学会年会  2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド(神戸)   Country:Japan  

  • アオダイショウにおけるアルビノ変異体の遺伝子解析:「岩国のシロヘビ」のアルビノ変異原因遺伝子の同定.

    岩西修造, 財津将平,柴田弘紀, 仁田坂英二

    本爬虫両棲類学会第56回大会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本大学(熊本)   Country:Japan  

  • EWAS研究で得られたKLF14遺伝子領域のエピゲノム変化は脂肪組織の炎症と相関する.

    岩谷千寿, 北島秀俊,山本健,前田泰孝, 園田紀之, 柴田弘紀, 井口登與志

    日本人類遺伝学会第62回大会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場(神戸)   Country:Japan  

  • DDHD1の新規責任変異の同定とノックアウトマウスの作成.

    森川拓弥, 三浦史郎, 大石裕晃, 藤岡竜太, 小坂健悟, 下條智史, 森山耕成, 柴田弘紀

    日本人類遺伝学会第62回大会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場(神戸)   Country:Japan  

  • 常染色体優性遺伝運動性ニューロパチー家系で同定したTDRKH内の新規非同義変異.

    小坂健悟, 三浦史郎, 下條智史, 長田周治, 森川拓弥, 藤岡竜太, 野村拓夫, 谷脇考恭, 柴田弘紀

    日本人類遺伝学会第62回大会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場(神戸)   Country:Japan  

  • 古代ゲノム解析への応用に向けたBACダブルキャプチャー法の検討

    小金渕佳江, 覚張隆史, 武島弘彦, 笠木聡, 佐藤丈寛, 田嶋敦, 柴田弘紀, 小川元之, 太田博樹

    第71回日本人類学会大会  2017.11 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学本郷キャンパス(東京)   Country:Japan  

  • An attempt of a new method, “BAC-double capture,” for applying to ancient genome analysis. International conference

    2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Okinawa   Country:Japan  

  • Heterozygous missense variant in TDRKH encoding tudor and KH domain-containing protein associated with autosomal dominant motor neuropathy. International conference

    Kosaka K, Miura S, Shimojo T, Nagata S, Morikawa T, Fujioka R, Nomura T, Taniwaki T, Shibata H.

    67th Annual Meeting of The American Society of Human Genetics,  2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • A case of familial Rippling muscle disease showing mosaic pattern of caveolin-3 in muscle biopsy suggesting an immunologic mechanism. International conference

    Furuya H, Arahata H, Furuta K, Shibata H, Fuji N.

    2017.10 

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    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 常染色体優性遺伝運動性ニューロパチー家系で同定したTDRKH内の新規非同義変異

    小坂健悟, 三浦史郎, 下條智史, 長田周治, 森川拓弥, 藤岡竜太, 野村拓夫, 谷脇考恭, 柴田弘紀

    日本遺伝学会第89回大会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山大学   Country:Japan  

  • 「岩国のシロヘビ」のアルビノ変異遺伝子の同定

    岩西修造, 財津将平, 柴田弘紀, 仁田坂英二

    日本遺伝学会第89回大会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山大学   Country:Japan  

  • Charcot-Marie-Tooth病におけるGNB4内の新規ミスセンス変異の同定

    森川拓弥, 三浦史郎, 藤岡竜太, 野田和人, 小坂健悟, 谷脇孝恭, 柴田弘紀

    日本遺伝学会第89回大会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山大学   Country:Japan  

  • Investigate of epigenetic biomarkers for pre-type 2 diabetes. International conference

    Chihiro Iwaya, Ken Yamamoto, Yasutaka Maeda, Noriyuki Sonoda, Hiroki Shibata, Toyoshi Inoguchi

    53rd Annual Meeting of the European Association for the Study of Diabetes  2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Portugal  

  • 肥満マウスにおけるKlf14遺伝子領域のエピゲノム変化と炎症との関連

    岩谷千寿, 柴田弘紀, 山本健, 北島秀俊, 池田陽介, 前田泰孝, 園田紀之, 小川佳宏, 井口登與志

    日本肥満学会第22回アディポサイエンス・シンポジウム  2017.8 

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    Event date: 2017.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千里ライフサイエンスセンター(大阪府豊中市)   Country:Japan  

  • The relation between epigenome changes of Klf14 region and chronic inflammation in obese mice. International conference

    Chihiro Iwaya, Yuka Kimura, Yosuke Ikeda, Hidetoshi Kitajima, Ken Yamamoto, Hiroki Shibata, Yasutaka Maeda, Noriyuki Sonoda, Yoshihiro Ogawa, Toyoshi Inoguchi

    American Diabetes Associaten, the 77th Scientific Sessions  2017.6 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 縄文時代人骨の古代ゲノム解析~3000年前の劣化DNAをいかにして読むか~

    覚張隆史, Ryan Schmidt, 佐藤丈寛, 松前ひろみ, Martin Sikora, Korneliussen Sand Thorfinn, Peter Damgaard, 埴原恒彦, 小川元之, 木村亮介, 石田肇, 設楽博己, 山田康弘, 柴田弘紀, 田嶋敦, Eske Willerslev, 太田博樹

    NGS現場の会 第五回研究会  2017.5 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台、仙台国際センター   Country:Japan  

  • 脂肪細胞におけるKLF14遺伝子のエピゲノム変化-加齢と肥満糖尿病における変化

    岩谷千寿, 木村裕佳, 池田陽介, 山本健, 北島秀俊, 柴田弘紀, 前田 泰孝, 園田 紀之, 小川佳宏, 井口登與志

    第60回日本糖尿病学会年次学術総会  2017.5 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋、名古屋国際会議場   Country:Japan  

  • 脂肪細胞におけるKLF14遺伝子のDNAメチル化変化が及ぼす炎症性変化

    岩谷千寿, 木村裕佳, 池田陽介, 山本健, 北島秀俊, 柴田弘紀, 前田 泰孝, 園田 紀之, 小川佳宏, 井口登與志

    第90回日本内分泌学会学術総会  2017.4 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都、ロームシアター京都   Country:Japan  

  • A comparison study of the mucosa-associated microbiota between inflamed and non-inflamed sites in ulcerative colitis patients. International conference

    Atsushi Hirano, Junji Umeno, Hiroki Shibata, Takanari Kitazono, Motohiro Esaki

    2017.2 

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  • 脂肪細胞におけるKLF14遺伝子のエピゲノム変化が及ぼす炎症性変化

    岩谷千寿, 榊 裕佳, 池田陽介, 山本健, 北島秀俊, 柴田弘紀, 前田 泰孝, 園田 紀之, 小川佳宏, 井口 登與志

    第31回日本糖尿病・肥満動物学会年次学術集会  2017.2 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:はまぎんホール ヴィアマーレ、横浜   Country:Japan  

  • Investigate of epigenetic biomarkers for pre-type 2 diabetes. International conference

    Chihiro Iwaya, Hidetoshi Kitajima, Ken Yamamoto, Hiroki Shibata, Noriyuki Sonoda, Toyoshi Inoguchi

    Human Genome Meeting 2017  2017.2 

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  • クサリヘビ科ヘビの分泌型ホスホリパーゼA2(PLA2)をコードする遺伝子クラスター領域の解析

    稲丸賢人, 千々岩崇仁, 山口和晃, 林みず紀, 柴田弘紀, 上田直子, 服部正策, 大野素徳

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜、パシフィコ横浜   Country:Japan  

  • KLF14遺伝子のエピゲノム変化が及ぼす脂肪細胞における炎症性変化及び代謝変化

    岩谷千寿, 山本健, 北島秀俊, 柴田弘紀, 前田 泰孝, 園田 紀之, 井口 登與志

    第39回日本分子生物学会年会  2016.12 

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜、横浜   Country:Japan  

  • 長期単独飼育されたオオアナコンダから発見された幼蛇

    坂部あい, 坂田修一, 平野雄三, 仁田坂 英二, 柴田弘紀

    第55回日本爬虫両棲類学会大会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:琉球大学   Country:Japan  

  • 糖尿病における炎症性変化とKLF14遺伝子エピゲノム変化の関連

    岩谷千寿, 山本健, 北島秀俊, 榊裕佳, 池田陽介, 柴田弘紀, 前田 泰孝, 園田 紀之, 井口 登與志

    第54回日本糖尿病学会九州地方会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:かごしま県民交流センター   Country:Japan  

  • 古代ゲノムシークエンシングのための技術改良

    太田博樹, 覚張隆史, ライアン・シュミット, 勝村啓史, 松前ひろみ, 埴原恒彦, 小川元之, 柴田弘紀, 佐伯和信, 分部哲秋, 弦本敏行, 佐藤丈寛, 木村亮介, 石田 肇

    第69回日本人類学会大会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:産業技術総合研究所臨海副都心センター、東京   Country:Japan  

  • ウクライナ・ヴァティーバ洞穴出土人骨の古遺伝学的解析

    ライアン・W・シュミット, 覚張隆史, 太田博樹, 松前ひろみ, 柴田弘紀, ジョーダン・カーステン, ミハイオ・ソハトスキー

    第69回日本人類学会大会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:産業技術総合研究所臨海副都心センター、東京   Country:Japan  

  • 渥美半島における縄文時代人骨の古代 DNA 分析

    覚張隆史, ライアン・W・シュミット, 松前ひろみ, 勝村啓史, 太田博樹, 埴原恒彦, 小川元之, 柴田弘紀, 茂原信生, 近藤 修, 米田 穣, 増山禎之, 設楽博己, 山田康弘

    第69回日本人類学会大会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:産業技術総合研究所臨海副都心センター、東京   Country:Japan  

  • KLF14遺伝子のエピゲノム変化に注目した糖尿病バイオマーカーの検証

    岩谷千寿, 北島秀俊, 山本健, 柴田弘紀, 前田 泰孝, 園田 紀之, 井口 登與志

    第66回日本体質医学会総会  2016.9 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:和歌山県JAビル   Country:Japan  

  • The preliminary report for the deep sequencing of the prehistoric Jomon genome from the Japanese archipelago.

    Society for Molecular Biology and Evolution Conference 2016  2016.7 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Australia  

  • クサリヘビ科ヘビの毒ホスホリパーゼA2遺伝子の形成と起源

    山口和晃, 千々岩崇仁, 池田直樹, 林みず紀, 柴田弘紀, 上田-小田直子, Yasuyuki Fukumaki, 服部正策, 大野素徳

    第38回日本分子生物学会年会、第88回日本生化学会大会合同大会  2015.12 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド   Country:Japan  

  • 新生仔マウスの精原幹細胞の形成と分化における 全ゲノムDNAメチル化およびトランスクリプトーム解析

    久保直樹, 藤 英博, 白根健次郎, 白川峰征, 小林久人, 佐藤哲也, 曾根秀利, 佐藤康人, 富澤信一, 鶴崎美徳, 柴田弘紀, 才津浩智, 鈴木 穣, 松本直通, 須山幹太, 河野友宏, 大保和之, 佐々木 裕之

    第38回日本分子生物学会年会、第88回日本生化学会大会合同大会  2015.12 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸ポートアイランド   Country:Japan  

  • 渥美半島における縄文時代人骨の古代DNA分析

    覚張隆史, ライアン・シュミット, 松前ひろみ, 勝村啓史, 太田博樹, 埴原恒彦, 小川元之, 柴田弘紀, 水嶋崇一郎, 茂原信生, 近藤修, 米田穣, 増山禎之, 設楽博己, 山田康弘

    第69回日本人類学会大会  2015.10 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:産業技術総合研究所 臨海副都心センター   Country:Japan  

  • 古代ゲノムシークエンシングのための技術改良

    太田博樹, 覚張隆史, ライアン・シュミット, 勝村啓史, 松前ひろみ, 埴原恒彦, 小川元之, 柴田弘紀, 佐伯和信, 分部哲秋, 弦本敏行, 佐藤丈寛, 木村亮介, 石田肇

    第69回日本人類学会大会  2015.10 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:産業技術総合研究所 臨海副都心センター   Country:Japan  

  • ヒト常染色体の1遺伝子座NGS解析に向けた低コストターゲットキャプチャー法の検討

    小金渕佳江, 覚張隆史, 笠木聡, 柴田弘紀, 太田博樹

    NGS現場の会第四回研究会  2015.7 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば国際会議場、筑波   Country:Japan  

  • アオダイショウにおけるアルビノ変異の原因遺伝子の解析

    財津将平, 柴田弘紀, 仁田坂 英二

    日本動物学会九州支部 (第68回)、九州沖縄植物学会 (第65回)、日本生態学会九州地区会 (第60回)  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡大学、福岡   Country:Japan  

  • 連鎖・エクソーム解析による常染色体優性ミオクローヌスてんかんの責任遺伝子検索

    山田浩平, 三浦史郎, 藤岡竜太, 佐野謙, 山本 健, 谷脇考恭, 柴田弘紀

    第37回日本分子生物学会年会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜、横浜   Country:Japan  

  • A novel missense mutation of ryanodine receptor 1 (RYR1) in a Japanese idiopathic hyper CK-emia family International conference

    Ken Sano, Shiroh Miura, Toshiya Fujiwara, Ken Yamamoto, Akiko Yorita, Kazuhito Noda, Hiroshi Kida, Koichi Azuma, Shinjiro Kaieda, Takayuki Taniwaki, Yasuyuki Fukumaki, Hiroki Shibata

    64th Annual Meeting of The American Society of Human Genetic  2014.10 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • ハブ(Protobothrops flavoviridis)の全ゲノム配列決定の現状と展望

    柴田弘紀, 山本真由美, タケット奈々, 小川智久, 森 一樹, 千々岩崇仁, 服部正策, 上田直子, 久原 哲, 大野素徳, 服巻保幸

    日本動物学会九州支部 (第67回)、九州沖縄植物学会 (第64回)、日本生態学会九州地区会 (第59回)、沖縄生物学会(第51回)合同沖縄大会  2014.5 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:琉球大学   Country:Japan  

  • マウス新生仔期の精原幹細胞の分化におけるメチローム変動

    久保直樹, 藤英博, 白根健次郎, 白川峰征, 神里亮人, 曾根秀利, 佐藤康人, 鶴崎美徳, 富澤信一, 柴田弘紀, 才津浩智, 松本直通, 大保和之, 佐々木裕之

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • クサリヘビ科グループIIEホスホリパーゼA2の発見と,ホンハブのグループIIA毒性ホスホリパーゼA2との進化的関与

    山口和晃, 千々岩崇仁, 柴田弘紀, 上田直子, 服部正策, 大野素徳

    第36回日本分子生物学会年会  2013.12 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 九州地域の孤発性および家族性筋萎縮性側索硬化症(ALS)の遺伝子解析

    古谷 博和, 渡邉 暁博, 荒畑 創, 河野 祐治, 藤井 直樹, 藤原敏弥, 鉾之原 敏博, 岩城 明子, 柴田 弘紀, 服巻 保幸

    第35回日本分子生物学会年会  2012.12 

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    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 日本産ハブ属(Protobothrops属)の島集団間におけるmtDNAの遺伝的分化

    柴田 弘紀, 山本真由美, 千々岩崇仁, 服部正策, 上田直子, 大野素徳, 服巻 保幸

    日本爬虫両棲類学会第51回大会  2012.11 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知県豊田市   Country:Japan  

  • カメ類における卵殻構造の多様性

    楠田哲士, 安川雄一郎, 柴田 弘紀, 吉崎範夫

    日本爬虫両棲類学会第51回大会  2012.11 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知県豊田市   Country:Japan  

  • Gene analysis of familial and sporadic amyotrophic lateral sclerosis (ALS) in Kyushu island of Japan. International conference

    62nd Annual Meeting of The American Society of Human Genetics  2012.11 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • NOD2 遺伝子座におけるクローン病原因変異の地域特異性

    中込滋樹, 間野修平, Lukasz Kozlowski, Janusz M. Bujnicki, 柴田 弘紀, 服巻 保幸, Judith R. Kidd, Kenneth K. Kidd, 河村正二, 太田博樹

    日本人類遺伝学会第57回大会  2012.10 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 日本産ハブ属(Protobothrops属)の島集団間におけるmtDNAの遺伝的分化

    柴田 弘紀, 山本真由美, 千々岩崇仁, 服部正策, 上田直子, 大野素徳, 服巻 保幸

    第84回日本遺伝学会大会  2012.9 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 日本産ハブ属(Protobothrops属)の島集団間におけるmtDNAの遺伝的分化

    柴田 弘紀, 山本真由美, 千々岩崇仁, 服部正策, 上田直子, 大野素徳, 服巻 保幸

    第14回日本進化学会大会  2012.8 

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    Event date: 2012.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • カメ類ミトコンドリアゲノムにおける翻訳フレームシフトの分子進化

    山田知江美, 柴田 弘紀, 熊澤慶伯

    第14回日本進化学会大会  2012.8 

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    Event date: 2012.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の島集団間の遺伝的分化

    柴田 弘紀, 山本真由美, 千々岩崇仁, 服部正策, 上田直子, 大野素徳, 服巻 保幸

    平成24年度日本生化学会九州支部例会  2012.5 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 奄美大島ハブの情報基盤としての遺伝子カタログの作製

    中村仁美、柴田弘紀、森一樹、田代康介、久原哲、千々岩崇仁、服部正策、大野素徳、服巻保幸、上田直子

    平成24年度日本生化学会九州支部例会  2012.5 

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    Event date: 2012.5

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 日本固有の毒蛇ハブ(Protobothrops flavoviridis)の島集団間の遺伝的分化

    柴田弘紀、山本真由美、千々岩崇仁、服部正策、上田直子、大野素徳、服巻保幸

    平成24年度日本生化学会九州支部例会  2012.5 

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    Event date: 2012.5

    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 奄美大島ハブの情報基盤としての遺伝子カタログの作製

    中村仁美, 柴田 弘紀, 森 一樹, 田代 康介, 久原 哲, 千々岩崇仁, 服部正策, 大野素徳, 服巻 保幸, 上田直子

    平成24年度日本生化学会九州支部例会  2012.5 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Non-neutral evolution observed in schizophrenia susceptibility genes.

    Hiroki Shibata

    2011.12 

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    Event date: 2011.12

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 連鎖・エクソームアプローチによる新規家族性ニューロパチーの変異検索

    服巻保幸、三浦史郎、山本真由美、貴田浩志、野田和人、加來庸一郎、岩城明子、綾部光芳、谷脇考恭、柴田弘紀

    第34回日本分子生物学会年会  2011.12 

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    Event date: 2011.12

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 連鎖解析とエクソームシークエンシングの併用による家族性運動感覚ニューロパチーの責任変異探索

    柴田弘紀、三浦史郎、貴田浩志、野田和人、加來庸一郎、岩城明子、綾部光芳、谷脇考恭、服巻保幸

    日本人類遺伝学会第56回大会  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • Population specific susceptibility to Crohn’s disease and signals of natural selection on standing variation. International conference

    2011.10 

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    Event date: 2011.10

    Presentation type:Oral presentation (general)  

    Venue:モントリオール   Country:Canada  

  • カメ類のミトコンドリアゲノムにおける分子進化速度の不均一性

    山田知江美、柴田弘紀、熊澤慶伯

    第13回日本進化学会大会  2011.7 

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    Event date: 2011.7

    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Resequencing of C2orf24 as a schizophrenia susceptibility gene revealed by GWAS with STR markers.

    Zhu Sun, Hiroki Shibata, Yasuyuki Fukumaki

    2010.12 

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    Event date: 2010.12

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific balancing selection in GRIN2B upstream region. International conference

    Shiroh Miura, Hiroki Shibata, Hiroshi Kida, Akiko Iwaki, Mitsuyoshi Ayabe, Hisamichi Aizawa, Takayuki Taniwaki, Yasuyuki Fukumaki

    60th Annual Meeting of The American Society of Human Genetics  2010.11 

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    Event date: 2010.11

    Presentation type:Oral presentation (general)  

    Country:United States  

  • SPASTおよびDPY30遺伝子の部分欠失を伴うSPG4家系

    三浦史郎、柴田弘紀、貴田浩司、野田和人、岩城明子、綾部光芳、相澤久道、谷脇考恭、服巻保幸

    日本人類遺伝学会第55回大会  2010.10 

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    Event date: 2010.10

    Presentation type:Oral presentation (general)  

    Venue:さいたま   Country:Japan  

  • Molecular evolutionary study of the ionotropic glutamate-receptor gene family as schizophrenia susceptibility genes: human-specific balancing selection in GRIN2B upstream region. International conference

    Shiroh Miura, Hiroki Shibata, Kazuhito Noda, Yoichiro Kaku, Hiroshi Kida, Akiko Iwaki, Mitsuyoshi Ayabe, Hisamichi Aizawa, Takayuki Taniwaki, Yasuyuki Fukumaki

    135th Annual Meeting of American Neurological Association  2010.10 

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    Event date: 2010.10

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Alcohol dehydrogenase (ADH) gene cluster in primates. International conference

    Hiroki Ooota, Rajinder Kaul, Hiroki Shibata, Atsushi Toyoda, Akio Fujiyama, William C. Speed, Judith R. Kidd, Maynard Olson, Shoji Kawamura, Kenneth K. Kidd

    International Primatological Society XXIII Congress  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • 筋萎縮性側索硬化症におけるFUS遺伝子変異の同定

    鉾之原敏博、三浦史郎、岩城明子、柴田弘紀、立石貴久、菊池仁志、古谷博和、吉良潤一、服巻保幸

    第32回日本分子生物学会年会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 軽症福山型筋ジストロフィー患者2名のfukutin遺伝子ハプロタイプ解析

    古谷博和、三浦史郎、柴田弘紀、服巻保幸

    第32回日本分子生物学会年会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • アルコール脱水素酵素遺伝子クラスターの霊長類における比較ゲノム解析

    太田博樹、Rajinder Kaul、Maynard Olson、柴田弘紀、河村正二、William C. Speed、Judith R. Kidd、Kenneth K. Kidd

    第32回日本分子生物学会年会  2009.12 

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    Event date: 2009.12

    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 筋萎縮性側索硬化症の日本人1家系におけるFUS遺伝子変異の同定

    鉾之原敏博、三浦史郎、岩城明子、柴田弘紀、立石貴久、菊池仁志、古谷博和、吉良潤一、服巻保幸

    日本人類遺伝学会第54回大会  2009.9 

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    Event date: 2009.9

    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 代謝型グルタミン酸受容体遺伝子群の上流調節領域の分子進化学的解析 II

    森田 彩、竹中 修、服巻 保幸、柴田 弘紀

    第31回日本分子生物学会年会、第81回日本生化学会大会合同大会  2008.12 

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    Event date: 2008.12

    Venue:神戸   Country:Japan  

  • 脊髄小脳失調症16型の原因はIP3受容体遺伝子のハプロ不全である

    岩城明子、河野祐治、三浦史郎、柴田弘紀、山本 健、松瀬 大、李 魏、古谷博和、大八木保政、谷脇考恭、吉良潤一、服巻保幸

    日本人類遺伝学会第53回大会  2008.9 

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    Event date: 2008.9

    Venue:横浜   Country:Japan  

  • ヘビ類におけるアルビノ変異の原因遺伝子の解析

    財津将平, 柴田弘紀, 仁田坂 英二

    第53回日本爬虫両棲類学会大会  2014.11 

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    Venue:神戸山手大学   Country:Japan  

  • 統合失調症とグルタミン酸脱炭酸酵素遺伝子およびグルタミン合成酵素遺伝子(GAD2, GLUL)の多型との関連解析

    新井伸作、柴田弘紀、境 真由美、二宮秀彰、岩田仲生、尾崎紀夫、服巻保幸

    第30回日本分子生物学会年会、第80回日本生化学会大会合同大会  2007.12 

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    Country:Japan  

  • Amphiphysin I遺伝子(AMPH)と精神分裂病との関連解析

    村田 慎也、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2001.12 

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    Venue:横浜   Country:Japan  

  • 代謝型グルタミン酸受容体3型遺伝子(GRM3)と精神分裂病との関連解析

    藤井 洋、柴田 弘紀、牧野 千絵子、菊田 るみこ、谷 綾子、平田 直嗣、柴田 篤志、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2001.12 

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    Venue:横浜   Country:Japan  

  • Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia.

    Shibata H, Joo A, Fujii Y, Tani A, Makino C, Hirata N, Kikuta R, Ninomiya H, Tashiro N, Fukumaki Y

    2001.12 

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    Country:Japan  

  • AMPA型グルタミン酸受容体サブタイプ4(GRIA4)遺伝子と精神分裂病との関連解析

    牧野 千絵子、藤井 洋、菊田 るみこ、谷 綾子、平田 直嗣、柴田 篤志、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2001.12 

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    Venue:横浜   Country:Japan  

  • NMDA型グルタミン酸受容体サブユニット1遺伝子(GRIN1)の5'上流領域における多型:精神分裂病との関連解析

    谷 綾子、菊田 るみこ、伊藤 加奈子、城尾 晶子、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2001.12 

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    Venue:横浜   Country:Japan  

  • グルタミン酸受容体遺伝子群と精神分裂病との関連解析

    柴田 弘紀、谷 綾子、藤井 洋、菊田 るみこ、牧野 千絵子、平田 直嗣、柴田 篤志、二宮 英彰、田代 信雄、服巻 保幸

    日本遺伝学会大会  2002.10 

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    Venue:福岡   Country:Japan  

  • 多因子病の遺伝因子をさがせ-精神分裂病とグルタミン酸受容体遺伝子群の関連解析

    柴田 弘紀

    日本遺伝学会大会  2002.10 

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    Venue:福岡   Country:Japan  

  • Association studies of the metabotropic glutamate receptor genes, GRM3 and GRM4, with schizophrenia. International conference

    Tani A, Fujii Y, Shibata H, Kikuta R, Makino C, Hirata N, Shibata A, Ninomiya T, Tashiro N, Fukumaki Y.

    The Xth World Congress of Psychiatric Genetics.  2002.10 

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    Presentation type:Oral presentation (general)  

    Country:Belgium  

  • Association study of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia in the Thai population. International conference

    Jarusuraisin N, Takaji M, Shibata H, Fukumaki Y.

    4th HUGO Pacific Meeting and 5th Asia-Pacific Conference on Human Genetics.  2002.10 

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    Presentation type:Oral presentation (general)  

    Country:Thailand  

  • 代謝型グルタミン酸受容体3型、4型および7型遺伝子(GRM3、GRM4、GRM7)における多型の精神分裂病との関連解析

    谷 綾子、柴田 弘紀、藤井 洋、平田 直嗣、高司 雅史、築原 智之、牧野 千絵子、菊田 るみこ、柴田 篤志、二宮 英彰、田代 信雄、服巻 保幸

    日本人類遺伝学会大会  2002.11 

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    Venue:名古屋   Country:Japan  

  • カイニン酸型およびAMPA型グルタミン酸受容体遺伝子(GRIK2、GRIA3、GRIA4)と精神分裂病との関連解析

    柴田 弘紀、菊田 るみこ、牧野 千絵子、藤井 洋、平田 直嗣、谷 綾子、柴田 篤志、二宮 英彰、田代 信雄、服巻 保幸

    日本人類遺伝学会大会  2002.11 

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    Venue:名古屋   Country:Japan  

  • ラットubiquitin-activating enzyme E1, Chr X遺伝子(Ube1x)のメタンフェタミン投与による発現変化とUBE1の統合失調症(精神分裂病)との関連解析

    平田 直嗣、濱村 みつ子、柴田 弘紀、小澤 秀俊、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2002.12 

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    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • AMPA型グルタミン酸受容体サブタイプ3遺伝子(GRIA3)と統合失調症(精神分裂病)との関連解析

    菊田 るみこ、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2002.12 

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    Venue:横浜   Country:Japan  

  • Identification of single-nucleotide polymorphisims in the human N-methyl D-aspartate receptor subunit NR2D gene (GRIN2D) and association study with schizophrenia.

    Chieko Makino, Toshihiro Aramaki, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    2002.12 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia.

    Hiroki Shibata, Atsushi Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

    2002.12 

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    Country:Japan  

  • 代謝型グルタミン酸受容体3型遺伝子(GRM3)と統合失調症(精神分裂病)との関連解析II ミ GRM3内の統合失調症感受性を決定する多型の検出

    高司 雅史、藤井 洋、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2002.12 

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    Venue:横浜   Country:Japan  

  • 代謝型グルタミン酸受容体8型遺伝子(GRM8)と統合失調症(精神分裂病)との関連解析

    高木 宏美、菊田 るみこ、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2002.12 

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    Venue:横浜   Country:Japan  

  • 代謝型グルタミン酸受容体4型および1型遺伝子(GRM4, GRM1)における多型と統合失調症(精神分裂病)との関連解析

    谷 綾子、向野 雅彦、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2002.12 

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    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 代謝型グルタミン酸受容体7型遺伝子(GRM7)と統合失調症(精神分裂病)との関連解析

    築原 智之、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本分子生物学会年会  2002.12 

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    Venue:横浜   Country:Japan  

  • Association studies of schizophrenia with evenly distributed SNPs in the metabotropic glutamate receptor gene regions. International conference

    Fukumaki Y, Tani A, Takaji M, Fujii Y, Shibata H.

    Human Genome Meeting 2003  2003.4 

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    Presentation type:Oral presentation (general)  

    Country:Mexico  

  • Association study of polymorphisms in the glutamate receptor genes, GRIK2, GRIA4, and GRM3 with Japanese schizophrenia. International conference

    Shibata H, Fujii Y, Makino C, Kikuta R, Hirata N, Tani A, Takaji M, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y.

    International Congress of Genetics  2003.7 

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    Country:Australia  

  • 統合失調症の遺伝解析の現状

    柴田 弘紀、服巻 保幸

    日本進化学会大会  2003.8 

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    Venue:福岡   Country:Japan  

  • Association studies of schizophrenia with the metabotropic glutamate receptor genes, GRM1, GRM5 regions. International conference

    Kikuta R, Tani A, Takaki, H, Takaji M, Shibata H, Ninomiya H, Tashiro N, Fukumaki Y.

    World Congress of Psychiatric Genetics  2003.10 

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    Presentation type:Oral presentation (general)  

    Country:Canada  

  • 代謝型グルタミン酸受容体1型、5型遺伝子(GRM1、GRM5)と統合失調症との関連解析

    菊田 るみこ、谷 綾子、高木 宏美、向野 雅彦、柴田 弘紀、二宮 英彰、田代 信雄、服巻 保幸

    日本人類遺伝学会大会  2003.10 

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    Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  • NMDA型グルタミン酸受容体サブユニットNR2D遺伝子(GRIN2D)の多型検索と統合失調症との関連解析

    柴田 弘紀、牧野 千絵子、二宮 英彰、田代 信雄、服巻 保幸

    日本人類遺伝学会大会  2003.10 

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    Venue:長崎   Country:Japan  

  • 等間隔に配置したSNPによる代謝型グルタミン酸受容体遺伝子群と統合失調症との関連解析

    服巻 保幸、柴田 弘紀、谷 綾子、藤井 洋、高木 宏美、平田 直嗣、菊田 るみこ、牧野 千絵子、柴田 篤志、二宮 英彰、田代 信維

    日本精神行動遺伝医学会  2003.10 

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    Venue:長崎   Country:Japan  

  • Association study of polymorphisms in two metabotropic glutamate receptor genes, GRM3 and GRM8 with schizophrenia. International conference

    Shibata H, Fujii Y, Takaji M, Takaki H, Kikuta R, Makino C, Tani A, Hirata N, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y.

    American Society of Human Genetics  2003.11 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Association and linkage disequilibrium between synapsin 2 and complexin2 gene and Korean schizophrenia. International conference

    Lee HJ, Kim JW, Kim MK, Kim SJ, Jin SY, Hong MS, Park HJ, Shin DH, Chung J, Shibata H, Fukumaki Y.

    American Society of Human Genetics  2003.11 

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    Presentation type:Oral presentation (general)  

    Country:United States  

  • 興奮性グルタミン酸トランスポーターEAAT2遺伝子(SLC1A2)の多型と統合失調症との関連解析

    鄧 湘東、柴田 弘紀、二宮 英彰、田代 信維、服巻 保幸

    日本分子生物学会年会  2003.12 

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    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • AMPA型グルタミン酸受容体サブタイプ1型遺伝子(GRIA1)と統合失調症との関連解析

    高司 雅史、柴田 弘紀、二宮 英彰、田代 信維、岩田 仲生、尾崎 紀夫、服巻 保幸

    日本分子生物学会年会  2003.12 

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    Venue:神戸   Country:Japan  

  • 代謝型グルタミン酸受容体5型遺伝子(GRM5)の多型と統合失調症との関連解析

    菊田 るみこ、高木 宏美、柴田 弘紀、二宮 英彰、田代 信維、服巻 保幸

    日本分子生物学会年会  2003.12 

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    Venue:神戸   Country:Japan  

  • カイニン酸型グルタミン酸受容体4型遺伝子(GRIK4)と統合失調症との関連解析

    柴田 弘紀、二宮 英彰、田代 信維、服巻 保幸

    日本分子生物学会年会  2003.12 

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    Venue:神戸   Country:Japan  

  • カイニン酸型グルタミン酸受容体サブタイプ3型遺伝子(GRIK3)と統合失調症との関連解析

    荒巻 敏寛、柴田 弘紀、二宮 英彰、田代 信維、岩田 仲生、尾崎 紀夫、服巻 保幸

    日本分子生物学会年会  2003.12 

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    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • グルタミン酸トランスポーターEAAT2遺伝子(SLC1A2)およびEAAT3遺伝子(SLC1A1)と統合失調症との関連解析

    服巻 保幸、鄧 湘東、柴田 弘紀、岩田 仲生、尾崎 紀夫、二宮 英彰、田代 信維

    第12回日本精神行動遺伝医学会  2004.10 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Association studies of schizophrenia with the ionotropic and metabotropic glutamate receptor genes.

    Fukumaki Y, Kikuta R, Makino C, Shibata H, Ninomiya H, Tashiro N.

    54th Annual Meeting of The American Society of Human Genetics.  2004.10 

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    Presentation type:Oral presentation (general)  

    Country:Canada  

  • Association study of polymorphisms in the GluR6, GluR7, KA1 and KA2 kainate receptor genes (GRIK2, GRIK3, GRIK4, GRIK5) with schizophrenia. International conference

    Shibata H, Aramaki T, Shibata A, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y.

    5th HUGO Pacific Meeting and 5th Asia-Pacific Conference on Human Genetics  2004.11 

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    Presentation type:Oral presentation (general)  

    Country:Singapore  

  • グリシントランスポーター1型及び2型遺伝子(SLC6A9, SLC6A5)と統合失調症との関連解析

    佐方功明、田中正視、柴田弘紀、二宮 英彰、田代 信維、岩田仲生、尾崎紀夫、服巻 保幸

    第27回日本分子生物学会年会  2004.12 

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    Venue:神戸   Country:Japan  

  • Association study of the glutamate transporter gene, SLC1A1 with schizophrenia in the Japanese population.

    Deng X, Shibata H, Ninomiya H, Tashiro N, Fukumaki Y.

    2004.12 

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    Country:Japan  

  • AMPA型グルタミン酸受容体2型遺伝子(GRIA2)及びカイニン酸型グルタミン酸受容体5型遺伝子(GRIK5)と統合失調症との関連解析

    柴田弘紀、小島理恵子、二宮 英彰、田代 信維、服巻 保幸

    第27回日本分子生物学会年会  2004.12 

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    Venue:神戸   Country:Japan  

  • AMPA型グルタミン酸受容体サブタイプ3遺伝子(GRIA3)と統合失調症との関連解析

    菊田るみこ、柴田弘紀、二宮 英彰、田代 信維、服巻 保幸

    第27回日本分子生物学会年会  2004.12 

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    Venue:神戸   Country:Japan  

  • Association study of the glutamate transporter genes, SLC1A1 and SLC1A2 with schizophrenia in the Japanese population. International conference

    Deng X, Shibata H, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y.

    Humann Genome Meeting 2005  2005.4 

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    Country:Japan  

  • 脳機能と遺伝子多型の関連の研究 I. 記憶と代謝型グルタミン酸受容体遺伝子多型

    實藤雅文、濱本香織、吉良龍太郎、柴田弘紀、中島大輔、鳥巣浩幸、酒井康成、武本環美、岩山真理子、服巻保幸、原 寿郎

    第47回日本小児神経学会総会  2005.5 

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    Venue:熊本   Country:Japan  

  • 脊髄小脳失調症16型の遺伝解析

    三浦史郎、柴田弘紀、古谷博和、松永宏美、三好安、小副川学、大八木保政、山田猛、谷脇考恭、吉良潤一、服巻保幸

    第50回日本人類遺伝学会大会  2005.9 

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    Venue:倉敷   Country:Japan  

  • 5q33.1領域における統合失調症感受性遺伝子の検索

    後藤大輝、柴田弘紀、高司雅史、二宮英彰、田代信維、服巻保幸

    第50回日本人類遺伝学会大会  2005.9 

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    Venue:倉敷   Country:Japan  

  • グルタミン酸受容体遺伝子群のヒトとチンパンジーにおける分子進化学的解析

    柴田弘紀、後藤大輝、田中邦佳、黒木陽子、豊田 敦、服部正平、榊 佳之、藤山秋佐夫、服巻保幸

    第77回日本遺伝学会大会  2005.9 

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    Venue:東京   Country:Japan  

  • 統合失調症感受性候補領域5q33.1におけるローカスワイド関連解析

    後藤大輝、柴田弘紀、高司雅史、二宮英彰、田代信維、Ngamwong JARUSURAISIN 、服巻保幸

    2005.10 

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    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Locus-wide association study in the 5q33.1 region for schizophrenia susceptibility genes International conference

    Goto H, Shibata H, Takaji M, Ninomiya H, Tashiro N, Jarusuraisin N, Fukumaki Y.

    55th Annual Meeting of The American Society of Human Genetics  2005.10 

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    Presentation type:Oral presentation (general)  

    Country:United States  

  • ローカスワイド関連解析による統合失調症感受性遺伝子の探索

    後藤 大輝、柴田 弘紀、高司 雅史、二宮英彰、田代 信維、Ngamwong JARUSURAISIN 、服巻 保幸

    第28回日本分子生物学会年会  2005.12 

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    Presentation type:Oral presentation (general)  

    Venue:福岡  

  • 脊髄小脳失調症16型の原因遺伝子の探索

    三浦 史郎、柴田 弘紀、古谷 博和、松永 宏美、三好 安、小副川 学、大八木 保政、山田 猛、谷脇 考恭、吉良 潤一、服巻 保幸

    第28回日本分子生物学会年会  2005.12 

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    Venue:福岡  

  • 中性アミノ酸トランスポーター1型及び2型遺伝子(SLC1A4, SLC1A5)と統合失調症の関連解析

    竹内 尚子、境 真由美、? 湘東、柴田 弘紀、二宮 英彰、田代 信維、岩田 仲生、尾崎 紀夫、服巻 保幸

    第28回日本分子生物学会年会  2005.12 

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    Venue:福岡  

  • Association study of the glutamate transporter genes, SLC1A3 and SLC1A6 with schizophrenia in the Japanese population.

    Xiandong Deng, Shinako Rachi, Mayumi Sakai, Naoko Takeuchi, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki

    2005.12 

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  • ヒト-チンパンジー分岐後におけるグルタミン酸受容体遺伝子群の分子進化学的解析

    柴田 弘紀、後藤 大輝、田中 邦佳、黒木 陽子、豊田 敦、服部 正平、榊 佳之、藤山 秋佐夫、服巻 保幸

    第28回日本分子生物学会年会  2005.12 

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    Venue:福岡  

  • グルタミン酸および中性アミノ酸トランスポーター遺伝子群と統合失調症との関連解析

    竹内 尚子、? 湘東、柴田 弘紀、良知 姿子、境 真由美、二宮 英彰、田代 信維、岩田 仲生、尾崎 紀夫、服巻 保幸

    第51回日本人類遺伝学会大会  2006.10 

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    Venue:米子  

  • Association study of polymorphisms in the glutamate transporter genes, SLC1A1, SLC1A3, SLC1A6 and the neutral amino acid transporter genes SLC1A4, SLC1A5 with schizophrenia. International conference

    Deng X, Takeuchi N, Shibata H, Rachi S, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y.

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress  2006.7 

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    Presentation type:Oral presentation (general)  

  • Locus-wide association study of schizophrenia with 43 genes located in the 5q33.1 region. International conference

    Shibata H, Goto H, Takaji M, Ninomiya H, Tashiro N. Jarusuraisin N, Fukumaki Y.

    11th International Congress of Human Genetics  2006.8 

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    Presentation type:Oral presentation (general)  

    Country:Australia  

  • Locus-wide association study of 43 genes in the 5q33.1 region with schizophrenia. International conference

    Shibata H, Goto H, Takaji M, Ninomiya H, Tashiro N. Jarusuraisin N, Fukumaki Y.

    The 8th International Meeting on Human Genome Variation and Complex Genome Analysis  2006.9 

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    Presentation type:Oral presentation (general)  

    Country:China  

  • グルタミン酸および中性アミノ酸トランスポーター遺伝子群と統合失調症との関連解析

    竹内 尚子、鄧 湘東、柴田 弘紀、良知 姿子、境 真由美、二宮 英彰、田代 信維、岩田 仲生、尾崎 紀夫、服巻 保幸

    第51回日本人類遺伝学会大会  2006.10 

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    Presentation type:Oral presentation (general)  

    Venue:米子   Country:Japan  

  • AMPA型グルタミン酸受容体サブユニットGluR1,GluR2遺伝子(GRIA1,GRIA2)の多型と統合失調症との関連解析

    新井 伸作, 柴田 弘紀, 境 真由美, 高司 雅史, 小島 理恵子, 菊田 るみこ, 二宮 英彰, 服巻 保幸

    分子生物学会2006フォーラム  2006.12 

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    Venue:名古屋   Country:Japan  

  • グルタミン酸脱炭酸酵素遺伝子GAD2とグルタミン合成酵素遺伝子GLULの多型と統合失調症との関連解析

    新井伸作、柴田弘紀、境 真由美、二宮秀彰、岩田仲生、尾崎紀夫、服巻保幸

    第52回日本人類遺伝学会、  2007.9 

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    Venue:東京   Country:Japan  

  • Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A9, SLC6A5 with schizophrenia. International conference

    Deng X, Sagata N, Takeuchi N,Tanaka M, Shibata H, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y.

    The XVth World Congress of Psychiatric Genetics  2007.10 

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    Country:Japan  

  • イオンチャンネル型グルタミン酸受容体遺伝子群14種の上流調節領域の分子進化学的解析

    渡邉和典、田中邦佳、後藤大輝、竹中 修、服巻保幸、柴田弘紀

    第30回日本分子生物学会年会、第80回日本生化学会大会合同大会、  2007.12 

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    Venue:横浜   Country:Japan  

  • フェンシクリジン(PCP)応答性遺伝子群を対象とした統合失調症感受性遺伝子の探索

    鄧 湘東、柴田弘紀、黒木俊秀、中原辰雄、橋本喜二郎、二宮英彰、岩田仲生、尾崎紀夫、服巻保幸

    第30回日本分子生物学会年会、第80回日本生化学会大会合同大会  2007.12 

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    Venue:横浜   Country:Japan  

  • 孤発性young-onset Parkinson's diseaseの遺伝解析

    三浦 史郎, 渡邊 笑奈, 比留木 成美, 森川 拓弥, 内山 雄介, 柴田 弘紀

    臨床神経学  2023.9  (一社)日本神経学会

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    Language:Japanese  

  • 動物毒って特異性が高いだけじゃない!どんどん拡がる面白い世界 毒蛇ハブのゲノム解析で明らかになった毒液タンパク質遺伝子の進化

    柴田 弘紀, 上田 直子, 千々岩 崇仁, 中村 仁美, 服部 正策, 服巻 保幸, 大野 素徳, 佐藤 矩行, 小川 智久

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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    Language:Japanese  

  • 動物毒って特異性が高いだけじゃない!どんどん拡がる面白い世界 ベノミクス研究により明らかになった毒蛇ハブの新規毒成分の機能と毒関連特殊機能の進化

    小川 智久, 柴田 弘紀, 上田 直子, 佐藤 矩行, 服部 正策, 日高 將文, 二井 勇人

    日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

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  • NBEA遺伝子の新規ミスセンス変異は発作性運動誘発性ジスキネジアの原因となりうる

    三浦 史郎, 鎌田 崇嗣, 下條 智史, 森川 拓弥, 内山 雄介, 柴田 弘紀

    臨床神経学  2022.10  (一社)日本神経学会

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    Language:Japanese  

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MISC

  • 「ベノミクス研究」の最前線:動物毒は,どのように進化してきたのか?

    小川智久, 柴田弘紀.

    化学と生物   2019.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    35 億年あまりの永い進化の産物である地球上の多種多様な生物. それらのなかには「毒素」という武器をもつ生物も存在します. これらの毒生物は, どのように進化して毒をもつに至ったのでしょうか? 近年ゲノム解析技術の進展により, モデル生物以外のゲノムも解析することが可能となり, 生物進化を読み解くための一つの重要なツールとなっています. 毒動物のゲノム解読や個々の毒成分の全容をプロテオームやトランスクリプトーム解析により明らかにする「ベノミクス研究」も進められてきました. ここでは, 毒蛇ハブのゲノム解読を中心に, 「ベノミクス研究」の最前線について解説します.

  • 統合失調症のリスク変異に関する進化的考察

    柴田弘紀

    生物の科学 遺伝   2013.5

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  • Glutamate receptor genes as candidates for schizophrenia susceptibility

    Fukumaki Y, Shibata H

    Drug Develop Res.   2003.10

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  • 連鎖不平衡

    柴田弘紀

    分子精神医学 先端医学社   2003.4

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  • RNAプライマーを用いたPCR

    古川宗一郎、柴田弘紀、林 健志

    実験医学増刊 (林 健志他編) 羊土社   1997.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Industrial property rights

Patent   Number of applications: 1   Number of registrations: 2
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Japan Society of Human Genetics

  • The American Society of Human Genetics

  • The Molecular Biology Society of Japan

  • The Genetics Society of Japan

  • Society of Evolutionary Studies, Japan

  • The Herpetological Society of Japan

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Committee Memberships

  • Councilor   Domestic

    2023.4 - 2024.3   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

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Research Projects

  • 眼症状を伴う遺伝性神経筋疾患の新規疾患単位の確立

    Grant number:23K06853  2023.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    三浦 史郎, 柴田 弘紀

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    Grant type:Scientific research funding

    白内障や網膜色素変性症といった眼科的疾患と痙性対麻痺やミオパチーといった内科的疾患を同時に患っている患者は少なくないと思われるが、実臨床では別々の疾患として眼科や内科・小児科に通院されているケースが多いと推測される。研究代表者は眼症状と神経筋症状が単一の遺伝的原因で生じていると考えられる2家系を見出した。1家系目は若年発症の網膜色素変性症、精神発達遅滞、側弯症を伴う筋萎縮症家系であるが、遺伝性筋疾患や遺伝性ニューロパチーの既知責任遺伝子に変異を認めず、2家系目は先天性白内障を伴う痙性対麻痺家系である。本研究では、各疾患の臨床像および責任遺伝子変異を明らかにする。

    CiNii Research

  • 協和キリン奨学寄附金/人工抗毒素産生系開発にむけた毒蛇咬症患者の高精度レパトア情報の整備

    2023

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    Grant type:Donation

  • Elucidation of evolutionary and molecular basis of animal special functions based on genome information and its application to highly functional sensors

    Grant number:22K19097  2022.6 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Grant type:Scientific research funding

    CiNii Research

  • 協和キリン奨学寄附金/人工抗毒素産生系開発に向けた免疫ウマの一細胞レパトア解析

    2022

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    Grant type:Donation

  • 第一三共奨学寄付プログラム/発作性運動誘発性ジスキネシアの新規責任遺伝子同定と病態解明に関する研究

    2021

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    Grant type:Donation

  • 協和キリン奨学寄附金/人工抗毒素産生系開発に向けた免疫ウマの一細胞レパトア解析

    2021

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    Grant type:Donation

  • アジアのコブラ類の全ゲノム解析 International coauthorship

    2019.6

    九州大学生体防御医学研究所 

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    Authorship:Coinvestigator(s) 

  • 第一三共奨学寄付プログラム/発作性運動誘発性ジスキネシアの遺伝解析研究

    2019

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    Grant type:Donation

  • ゲノム情報を用いたハブ毒タンパク質の包括的多様性および進化過程の解明

    Grant number:18H02498  2018 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    柴田 弘紀, 小川 智久

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    Authorship:Principal investigator  Grant type:Scientific research funding

    沖縄本島、小宝島、西表島産個体の全ゲノムアセンブリを取得し(先進ゲノム支援による)、金属プロテアーゼなどの毒液タンパク質遺伝子族で、集団間でクラスター構造が異なることを見出した。また14島計150個体のmtDNA配列を取得し集団遺伝学的解析を行い、ハブの集団構造には地理的要因が強く影響することを示した。また、9島47個体の毒腺のRNAseqで、集団間で有意に発現量の異なる遺伝子を同定したが毒液タンパク質遺伝子はほぼ含まれていなかった。一方毒液の2D解析では、集団間で発現パターンの明確な違いが観察された。そのため毒液タンパク質発現の集団間の差異は、翻訳/修飾レベルで生じている可能性が示唆された。

    CiNii Research

  • 第一三共奨学寄付プログラム/発作性運動誘発性ジスキネシアの遺伝解析研究

    2018

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    Grant type:Donation

  • 第一三共奨学寄付プログラム/発作性運動誘発性ジスキネシアの遺伝解析研究

    2017

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    Grant type:Donation

  • 遺伝子間相互作用解析を活用した口唇口蓋裂疾患感受性遺伝子の解明

    Grant number:16K11689  2016 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • エイジングに伴うエピゲノム変化に注目した糖尿病バイオマーカーの解明(岩谷千寿)

    2016 - 2017

    日本学術振興会  特別研究員

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    Grant type:Joint research

  • 痙性対麻痺のモデルマウスの解析

    2014.4

    九州大学生体防御医学研究所 

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    Authorship:Principal investigator 

  • 第1番染色体に連鎖する新規遺伝性ニューロパチーの分子基盤解明

    Grant number:26460411  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • ミトゲノム解析と核マーカータイピングによる日本産ハブ属3種の遺伝的集団構造の研究

    Grant number:25440214  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 日本固有の毒蛇ハブの島嶼集団間の多様性解析

    2012.4

    九州大学生体防御医学研究所 

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    Authorship:Principal investigator 

  • 毒蛇ハブとその近縁種の全ゲノム解析

    2012.4

    九州大学生体防御医学研究所 

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    Authorship:Principal investigator 

  • 日本固有の毒蛇ハブの全遺伝子カタログ作成

    2011.9

    九州大学生体防御医学研究所 

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    Authorship:Principal investigator 

  • 連鎖解析と次世代シークエンサによるターゲッテドリシークエンスによる疾患責任変異探索

    2010.4

    九州大学生体防御医学研究所 

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    Authorship:Principal investigator 

  • 統合失調症感受性遺伝子多型の進化医学的解析

    Grant number:21590360  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ヒト高次脳機能関連遺伝子群の分子進化学的解析

    Grant number:20017021  2008 - 2009

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 精神疾患関連遺伝子群の分子進化学的研究

    2007.4

      More details

    Authorship:Principal investigator 

  • ヒト高次脳機能関連遺伝子群の分子進化学的解析

    Grant number:20017021  2007 - 2008

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 統合失調症関連遺伝子群を突破口とした”humanness”の起源の解明

    Grant number:18017020  2006 - 2007

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • グルタミン酸受容体遺伝子群のヒト上科における多様性と”humanness”の起源

    Grant number:17018027  2005

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ローカスワイド関連解析による統合失調症感受性遺伝子の探索と同定〜多面的アプローチによる候補遺伝子探索と大規模検体による関連解析

    2005

    第37回内藤記念科学奨励金(研究助成)

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    Authorship:Principal investigator  Grant type:Contract research

  • グルタミン酸受容体遺伝子群のチンパンジー配列の決定と比較解析

    2004.4

    九州大学 生体防御医学研究所 遺伝情報実験センター ゲノム機能学 (日本) 

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    Authorship:Principal investigator 

  • 統合失調症モデル動物脳における遺伝子発現:DNA microarrayによる解析

    2003.4

    国立肥前療養所(日本) 

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    Authorship:Coinvestigator(s) 

  • 精神分裂病感受性遺伝子としてのグルタミン酸受容体遺伝子群の包括的研究

    2002.4

    九州大学 生体防御医学研究所 遺伝情報実験センター ゲノム機能学(日本) 

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    Authorship:Principal investigator 

  • 精神分裂病感受性遺伝子としてのグルタミン酸受容体遺伝子群の包括的研究

    Grant number:14704056  2002 - 2004

    科学研究費助成事業  若手研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • グルタミン酸受容体遺伝子群の多型検索及び精神分裂病との相関解析

    2000.4 - 2002.3

    九州大学 生体防御医学研究所 遺伝情報実験センター ゲノム機能学 (日本) 

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    Authorship:Principal investigator 

  • グルタミン受容体遺伝子群の多型検索及び精神分裂病との相関解析

    Grant number:12771455  2000 - 2001

    科学研究費助成事業  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Class subject

  • 人類遺伝学(歯学部)

    2024.4 - 2024.9   First semester

  • 人類遺伝学(理学部)

    2024.4 - 2024.9   First semester

  • 最新トピックスから学ぶ生命科学入門

    2023.12 - 2024.2   Winter quarter

  • 遺伝学/生体の構造と機能 VI

    2023.10 - 2024.3   Second semester

  • 生命医科学研究入門

    2023.10 - 2024.3   Second semester

  • 生命医科学特論 III

    2023.6 - 2023.8   Summer quarter

  • ゲノム医科学講究

    2023.4 - 2024.3   Full year

  • 学際開拓創成セミナーI

    2023.4 - 2024.3   Full year

  • 生命医科学特別研究

    2023.4 - 2024.3   Full year

  • 人類遺伝学(理学部)

    2023.4 - 2023.9   First semester

  • 人類遺伝学(歯学部)

    2023.4 - 2023.9   First semester

  • 最新トピックスから学ぶ生命科学入門

    2022.12 - 2023.2   Winter quarter

  • 遺伝学/生体の構造と機能 VI

    2022.10 - 2023.3   Second semester

  • 生命医科学研究入門

    2022.10 - 2023.3   Second semester

  • ゲノム医科学講究

    2022.4 - 2023.3   Full year

  • 学際開拓創成セミナーI

    2022.4 - 2023.3   Full year

  • 生命医科学特別研究

    2022.4 - 2023.3   Full year

  • 人類遺伝学(理学部)

    2022.4 - 2022.9   First semester

  • 人類遺伝学(歯学部)

    2022.4 - 2022.9   First semester

  • 生命医科学特論 I

    2022.4 - 2022.6   Spring quarter

  • 最新トピックスから学ぶ生命科学入門

    2021.12 - 2022.2   Winter quarter

  • 遺伝学/生体の構造と機能 VI

    2021.10 - 2022.3   Second semester

  • 生命医科学特論IV

    2021.6 - 2021.8   Summer quarter

  • ゲノム医科学講究

    2021.4 - 2022.3   Full year

  • 学際開拓創成セミナーI

    2021.4 - 2022.3   Full year

  • 生命医科学特別研究

    2021.4 - 2022.3   Full year

  • 人類遺伝学(歯学部)

    2021.4 - 2021.9   First semester

  • 人類遺伝学(理学部)

    2021.4 - 2021.9   First semester

  • 最新トピックスから学ぶ生命科学入門

    2020.12 - 2021.2   Winter quarter

  • 遺伝学/生体の構造と機能 VI

    2020.10 - 2021.3   Second semester

  • 生命医科学特論IV

    2020.10 - 2020.12   Fall quarter

  • ゲノム医科学講究

    2020.4 - 2021.3   Full year

  • 学際開拓創成セミナーI

    2020.4 - 2021.3   Full year

  • 生命医科学特別研究

    2020.4 - 2021.3   Full year

  • 人類遺伝学(歯学部)

    2020.4 - 2020.9   First semester

  • 人類遺伝学(理学部)

    2020.4 - 2020.9   First semester

  • 遺伝学/生体の構造と機能 VI

    2019.10 - 2020.3   Second semester

  • 最新トピックスから学ぶ生命科学入門Ⅲ

    2019.10 - 2019.12   Fall quarter

  • 生命医科学特論IV

    2019.10 - 2019.12   Fall quarter

  • ゲノム医科学講究

    2019.4 - 2020.3   Full year

  • 学際開拓創成セミナーI

    2019.4 - 2020.3   Full year

  • 生命医科学特別研究

    2019.4 - 2020.3   Full year

  • 人類遺伝学(歯学部)

    2019.4 - 2019.9   First semester

  • 人類遺伝学(理学部)

    2019.4 - 2019.9   First semester

  • 遺伝学/生体の構造と機能 VI

    2018.10 - 2019.3   Second semester

  • 最新トピックスから学ぶ生命科学入門Ⅲ

    2018.10 - 2018.12   Fall quarter

  • ゲノム医科学講究

    2018.4 - 2019.3   Full year

  • 学際開拓創成セミナーI

    2018.4 - 2019.3   Full year

  • 生命医科学特別研究

    2018.4 - 2019.3   Full year

  • 生命医科学研究入門

    2018.4 - 2018.9   First semester

  • 人類遺伝学(理学部)

    2018.4 - 2018.9   First semester

  • 人類遺伝学(歯学部)

    2018.4 - 2018.9   First semester

  • 生命医科学特論I

    2018.4 - 2018.6   Spring quarter

  • ゲノム医科学特論

    2017.10 - 2018.3   Second semester

  • 遺伝学/生体の構造と機能 VI

    2017.10 - 2018.3   Second semester

  • 最新トピックスから学ぶ生命科学入門 II

    2017.10 - 2018.3   Second semester

  • ゲノム医科学講究

    2017.4 - 2018.3   Full year

  • 学際開拓創成セミナーI

    2017.4 - 2018.3   Full year

  • 生命医科学特別研究

    2017.4 - 2018.3   Full year

  • 生命医科学研究入門

    2017.4 - 2017.9   First semester

  • 人類遺伝学(理学部)

    2017.4 - 2017.9   First semester

  • 人類遺伝学(歯学部)

    2017.4 - 2017.9   First semester

  • 生命医科学特論I

    2017.4 - 2017.6   Spring quarter

  • 生命医科学研究入門

    2016.10 - 2017.3   Second semester

  • 遺伝学/生体の構造と機能 VI

    2016.10 - 2017.3   Second semester

  • 最新トピックスから学ぶ生命科学入門 II

    2016.10 - 2017.3   Second semester

  • ゲノム医科学講究

    2016.4 - 2017.3   Full year

  • 学際開拓創成セミナーI

    2016.4 - 2017.3   Full year

  • 生命医科学特別研究

    2016.4 - 2017.3   Full year

  • 人類遺伝学(歯学部)

    2016.4 - 2016.9   First semester

  • ゲノム医科学基礎

    2016.4 - 2016.9   First semester

  • 人類遺伝学(理学部)

    2016.4 - 2016.9   First semester

  • 生命医科学研究入門

    2015.10 - 2016.3   Second semester

  • ゲノム医科学特論

    2015.10 - 2016.3   Second semester

  • 遺伝学/生体の構造と機能 VI

    2015.10 - 2016.3   Second semester

  • ゲノム医科学講究

    2015.4 - 2016.3   Full year

  • 学際開拓創成セミナーI

    2015.4 - 2016.3   Full year

  • 生命医科学特別研究

    2015.4 - 2016.3   Full year

  • 人類遺伝学(歯学部)

    2015.4 - 2015.9   First semester

  • ゲノム医科学基礎

    2015.4 - 2015.9   First semester

  • 人類遺伝学(理学部)

    2015.4 - 2015.9   First semester

  • 生命科学概論 I

    2014.10 - 2015.3   Second semester

  • ゲノム医科学特論

    2014.10 - 2015.3   Second semester

  • 遺伝学/生体の構造と機能 VI

    2014.10 - 2015.3   Second semester

  • 生命医科学特別研究

    2014.4 - 2015.3   Full year

  • 学際開拓創成セミナーI

    2014.4 - 2015.3   Full year

  • ゲノム医科学講究

    2014.4 - 2015.3   Full year

  • 人類遺伝学(歯学部)

    2014.4 - 2014.9   First semester

  • ゲノム医科学基礎

    2014.4 - 2014.9   First semester

  • 人類遺伝学(理学部)

    2014.4 - 2014.9   First semester

  • 生命科学概論 I

    2013.10 - 2014.3   Second semester

  • 生命医科学特別研究

    2013.4 - 2014.3   Full year

  • 学際開拓創成セミナーI

    2013.4 - 2014.3   Full year

  • 学際開拓創成セミナーII

    2013.4 - 2014.3   Full year

  • ゲノム医科学講究

    2013.4 - 2014.3   Full year

  • 人類遺伝学(歯学部)

    2013.4 - 2013.9   First semester

  • ゲノム医科学基礎

    2013.4 - 2013.9   First semester

  • 人類遺伝学(理学部)

    2013.4 - 2013.9   First semester

  • ゲノム医科学特論

    2012.10 - 2013.3   Second semester

  • 人類遺伝学(歯学部)

    2012.4 - 2012.9   First semester

  • ゲノム医科学基礎

    2012.4 - 2012.9   First semester

  • 人類遺伝学(理学部)

    2012.4 - 2012.9   First semester

  • ゲノム機能学特論

    2011.10 - 2012.3   Second semester

  • 人類遺伝学

    2011.4 - 2011.9   First semester

  • ゲノム医科学基礎

    2011.4 - 2011.9   First semester

  • 人類生物学

    2011.4 - 2011.9   First semester

  • ゲノム機能学特論

    2010.10 - 2011.3   Second semester

  • 人類遺伝学

    2010.4 - 2010.9   First semester

  • 生物物理学研究法

    2010.4 - 2010.9   First semester

  • ゲノム医科学基礎

    2010.4 - 2010.9   First semester

  • 人類生物学

    2010.4 - 2010.9   First semester

  • 人類遺伝学

    2009.4 - 2009.9   First semester

  • 生物物理学研究法

    2009.4 - 2009.9   First semester

  • ゲノム医科学基礎

    2009.4 - 2009.9   First semester

  • 人類生物学

    2009.4 - 2009.9   First semester

  • ゲノム機能学特論

    2008.10 - 2009.3   Second semester

  • 人類遺伝学

    2008.4 - 2008.9   First semester

  • 生物物理学研究法

    2008.4 - 2008.9   First semester

  • ゲノム機能学基礎

    2008.4 - 2008.9   First semester

  • ゲノム機能学特論

    2007.10 - 2008.3   Second semester

  • ゲノム機能学基礎

    2007.4 - 2007.9   First semester

  • 人類遺伝学

    2007.4 - 2007.9   First semester

  • 生物物理学研究法

    2007.4 - 2007.9   First semester

  • ゲノム機能学特論

    2006.10 - 2007.3   Second semester

  • ゲノム機能学基礎

    2006.4 - 2006.9   First semester

  • 人類遺伝学

    2006.4 - 2006.9   First semester

  • 生物物理学研究法

    2006.4 - 2006.9   First semester

  • ゲノム機能学特論

    2005.10 - 2006.3   Second semester

  • ゲノム機能学基礎

    2005.4 - 2005.9   First semester

  • 人類遺伝学

    2005.4 - 2005.9   First semester

  • 生物物理学研究法

    2005.4 - 2005.9   First semester

  • ゲノム機能学基礎

    2004.4 - 2004.9   First semester

  • 人類遺伝学

    2004.4 - 2004.9   First semester

  • 生物物理学研究法

    2004.4 - 2004.9   First semester

  • ゲノム機能学基礎

    2003.4 - 2003.9   First semester

  • 人類遺伝学

    2003.4 - 2003.9   First semester

  • 生物物理学研究法

    2003.4 - 2003.9   First semester

  • 生物物理学研究法

    2002.4 - 2002.9   First semester

▼display all

FD Participation

  • 2023.8   Role:Participation   Title:SENTAN-Q の目指すもの:九州大学におけるダイバーシティ推進

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.4   Role:Participation   Title:職場における落とし穴

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.12   Role:Participation   Title:学術論文の購読と投稿とこれから

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2021.7   Role:Participation   Title:ハゲタカジャーナルの実態と対策

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.12   Role:Participation   Title:システム生命科学府「障害のある学生の合理的配慮」に関するFD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.11   Role:Participation   Title:令和2年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.10   Role:Participation   Title:令和元年度馬出地区4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.2   Role:Participation   Title:情報セキュリティ関連FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.10   Role:Participation   Title:医師のための働き方見直し〜ワークライフバランスとダイバーシティの観点から〜

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.10   Role:Participation   Title:馬出地区キャンパスFD「なぜ今『女性活躍推進法』か?    —男女共同参画の必要性と九州大学における取組み—」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.6   Role:Participation   Title:平成28年度第2回 全学FD「教育の質向上支援プログラム成果発表会」

    Organizer:University-wide

  • 2011.12   Role:Participation   Title:システム生命科学府FD「システム生命科学府のグローバル化について」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.10   Role:Participation   Title:システム生命科学府FD「アカデミックハラスメントについてー問題の共有と防止に向けてー」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.1   Role:Participation   Title:平成20年度第3回 全学FD「教育GPを通じた教育改革」

    Organizer:University-wide

  • 2008.12   Role:Participation   Title:システム生命科学府平成20年度FDセミナー「大学院教育GPについて」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2008.2   Role:Participation   Title:システム生命科学府FD研修会「研究・教育者等のキャリアパスの育成と課題について」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2007.4   Role:Participation   Title:平成19年第1回 全学FD「新任教員の研修」

    Organizer:University-wide

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2023  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2022  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2021  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2020  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2019  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2018  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2017  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2016  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2015  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2014  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2013  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2012  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2011  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

  • 2010  福岡大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:前期

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Outline of Social Contribution and International Cooperation activities

  • 「バイオインフォマティクス夏の学校」に講師として参加しPCRに関する実習を行った(2010年7月4日)
    「ミニゲノムひろば2009 in 福岡」に参加し一般の方々に研究成果を報告した(2009年12月20日)
    「ゲノムひろば2009 in アキバ」に参加し一般の方々に研究成果を報告した(2009年08月01-02日)
    「ミニゲノムひろば2008 in 福岡」に参加し一般の方々に研究成果を報告した(2008年12月21日)
    「ゲノムひろば2008 in 名古屋」に参加し一般の方々に研究成果を報告した(2008年10月25-26日)
    「ミニゲノムひろば2007 in 福岡」に参加し一般の方々に研究成果を報告した(2007年12月23日)
    「ミニゲノムひろば2006 in 福岡」に参加し一般の方々に研究成果を報告した(2006年12月10日)
    「ゲノムひろば2005 in 福岡〜生命のからくりを分子でみる」に参加し一般の方々に研究成果を報告した(2005年12月11日)
    「ゲノムひろば2004 in 福岡」に参加し一般の方々に研究成果を報告した(2004年07月31-08月01日)
    九州北部税理士会博多支部研修会において「DNAの不思議」と題したセミナーをおこなった(2003年12月04日)
    「ゲノムひろば2003 in 京都」に参加し一般の方々に研究成果を報告した(2003年11月08-09日)
    「ゲノムひろば2003 in 福岡」に参加し一般の方々に研究成果を報告した(2003年11月01-02日)
    「ゲノムひろば2002 in 福岡」に参加し一般の方々に研究成果を報告した(2002年11月16-17日)

Social Activities

  • 「バイオインフォマティクス夏の学校」に講師として参加しPCRに関する実習を指導した。

    福岡県高等学校生物部会、九州大学大学院システム生命科学府  九州大学大学院 システム生命科学府講義棟  2010.7

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 「ミニゲノムひろば2009 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  エルガーラ 大ホール 福岡  2009.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ゲノムひろば2009 in アキバ」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  AKIBA_SQUARE 秋葉原  2009.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ミニゲノムひろば2008 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  パピヨン24 ガスホール 福岡  2008.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ゲノムひろば2008 in 名古屋」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  名古屋大学 豊田講堂・シンポジオンホール  2008.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ミニゲノムひろば2007 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  イムズホール 福岡  2007.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ミニゲノムひろば2006 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  イムズホール 福岡  2006.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ゲノムひろば2005 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  エルガーラホール 福岡  2005.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ゲノムひろば2004 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  エルガーラホール 福岡  2004.7

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 九州北部税理士会博多支部で「DNAの不思議」と題した研修会を行った

    九州北部税理士会  九州北部税理士会博多支部  2003.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 「ゲノムひろば2003 in 京都」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  京都三井ホール  2003.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ゲノムひろば2003 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  エルガーラホール 福岡  2003.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「ゲノムひろば2002 in 福岡」に参加し一般の方々に研究成果を報告した

    文部科学省科学研究費 特定領域研究ゲノム4領域  エルガーラホール 福岡  2002.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

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Media Coverage

  • ハブ毒オミクス研究の紹介(スタジオ出演) TV or radio program

    NHK「サイエンスZero」  2022.7

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    ハブ毒オミクス研究の紹介(スタジオ出演)

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    子供の科学(2018年10月号)  2018.10

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    赤旗  2018.8

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    産経新聞  2018.8

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    南海日日新聞  2018.7

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の論文発表にともなう研究の紹介 TV or radio program

    琉球朝日放送(QAB)  2018.7

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    ハブ全ゲノム解読の論文発表にともなう研究の紹介

  • ハブ全ゲノム解読の論文発表にともなう研究の紹介 TV or radio program

    琉球放送(RBC)  2018.7

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    ハブ全ゲノム解読の論文発表にともなう研究の紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    朝日新聞  2018.7

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    読売新聞  2018.7

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    琉球新報  2018.7

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    ハブ全ゲノム解読の研究紹介

  • ハブ全ゲノム解読の研究紹介 Newspaper, magazine

    沖縄タイムス  2018.7

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    ハブ全ゲノム解読の研究紹介

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Travel Abroad

  • 2019.12

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:国立清華大学

  • 2003.6

    Staying countory name 1:Korea, Republic of   Staying institution name 1:慶煕大学