2025/01/08 更新

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写真a

タナカ マサル
田中 賢
TANAKA MASARU
所属
先導物質化学研究所 ソフトマテリアル部門 教授
工学府 応用化学専攻(併任)
工学府 機械工学専攻(併任)
職名
教授
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研究分野

  • ナノテク・材料 / 高分子化学

学位

  • 博士(学位)

経歴

  • テルモ株式会社

    テルモ株式会社

  • 北海道大学 東北大学 山形大学

研究テーマ・研究キーワード

  • 研究テーマ:タンパク質吸着

    研究キーワード:タンパク質吸着

    研究期間: 2024年

  • 研究テーマ:バイオマテリアル

    研究キーワード:バイオマテリアル

    研究期間: 2024年

  • 研究テーマ:バイオ界面

    研究キーワード:バイオ界面

    研究期間: 2024年

  • 研究テーマ:中間水

    研究キーワード:中間水

    研究期間: 2024年

  • 研究テーマ:医療機器

    研究キーワード:医療機器

    研究期間: 2024年

  • 研究テーマ:生体親和性

    研究キーワード:生体親和性

    研究期間: 2024年

  • 研究テーマ:界面水

    研究キーワード:界面水

    研究期間: 2024年

  • 研究テーマ:細胞接着

    研究キーワード:細胞接着

    研究期間: 2024年

  • 研究テーマ:高分子

    研究キーワード:高分子

    研究期間: 2024年

  • 研究テーマ:高分子合成

    研究キーワード:高分子合成

    研究期間: 2024年

  • 研究テーマ:生体親和性に優れた診断・治療用ソフトバイオマテリアルの設計と医療機器への応用

    研究キーワード:生体親和性 細胞接着 バイオ界面 水の構造 医療機器

    研究期間: 2015年3月 - 2025年12月

受賞

  • https://www.soft-material.jp/achievement/awards

    2024年3月  

     詳細を見る

    Fellow of Biomaterials Science and Engineering (FBSE)

  • JHeC 2022 アイディアコンテスト部門ファイナリスト 優秀賞

    2022年1月  

     詳細を見る

    当研究室の中間水コンセプトによる医療製品創出に関するアイディアが、経済産業省 主催のJHeC 2022 で優秀賞および特別賞を受賞した。
    https://www.soft-material.jp/information/news/article-4446

  • 学会賞

    2021年11月   日本バイオマテリアル学会  

  • Kawasaki Deep Tech Accelerator 賞

    2021年8月  

  • 日本バイオマテリアル学会 学会賞

    2021年7月   日本バイオマテリアル学会   中間水コンセプトによるバイオイナート材料の設計

     詳細を見る

    医療材料に関する世界初の設計指針を創成した。

  • 優秀賞

    2021年3月   日本対がん協会福岡支部 がん研究助成金   細胞膜上の水和水に着目した癌細胞認識性リガンドの確立

  • 奨励賞

    2020年12月   第30回日本MRS年次大会   Synthesis of Silsesquioxane/poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombogenicity and Vascular Endothelial Cell Adhesiveness

  • Award For Poster Presentation

    2019年11月   China-Japan Biopolymer Symposium (1)  

  • Award For Poster Presentation

    2019年11月   China-Japan Biopolymer Symposium  

  • 市村学術賞功績賞

    2019年4月  

  • 第51回市村学術賞功績賞

    2019年4月   公益財団法人 市村清新技術財団   医療来分子の開発と生体親和性発現機構の解明

     詳細を見る

    医療高分子が血液などの生体成分に接触すると、異物反応が進行し不具合が生じる。病気の治療や超早期診断など、高齢社会においてニーズの大きい健康・医療技術や製品の開発には、製品性能を決定付ける製品の表面を形成する医療高分子の安全性と機能の向上が欠かせない。
    受賞者らは、合成高分子であるpoly(2-methoxyethyl acrylate)(PMEA)が、中間水(材料表面に緩やかに結合した水分子)を豊富に含む材料表面を作り出し、この中間水がタンパク質や細胞などの吸着を防ぐことを示してきた。PMEAコーティング技術は、研究支援機器、医療機器として実用化され、厚生労働省の認可を受けている。例えば、PMEAコーティング人工心肺は世界No.1のシェアを取り続けているなど、我が国発の世界に誇る実績を有している。これにより、我が国の研究開発総合力のプレゼンス向上に貢献した。
    一般に、合成高分子が生体に接触すると、直ちに水分子が材料表面に吸着する。吸着した水分子は、以下の2種類に分けられる。材料に強く結合し分子運動性が低下した不凍水と材料に弱く結合し分子運動性が高い自由水である。さらに、自由水と不凍水の中間的な性質を示す中間水が形成される。この中間水が生体親和性の発現に大きな影響を与えることが明らかにし、中間水に着目した生体親和性材料のスクリーニングにつながる「中間水コンセプト」を世界で初めて見出した。この中間水は、生体親和性を示す合成高分子と生体分子に共通して観測されることを見出した(図1)。
    また、受賞者らは、独自に設計したPMEA誘導体により適切な中間水量を与えると、血球細胞などの血栓を作る生体成分の吸着は抑制されたまま、がん細胞が選択的に接着することを見出し、基本特許を取得した。がん細胞をダメージレスに分離回収可能なので、分離回収した癌細胞を培養し、抗がん剤の評価が可能となった。受賞者らが見出した合成高分子への生体成分の吸着性を制御可能な中間水のコンセプトは、新世代医療高分子開発に大きく貢献した。

  • 第28回日本MRS年次大会奨励賞

    2018年12月   Analysis of intemediate water by Soft X-ray absorption/emission and Terahertz spectroscopy

  • Biomaterials lnternatiomal 2017 Best Poster Paper Award

    2017年8月   Biomaterials lnternatiomal  

  • International Association of Advanced Materials Scientists Award for the year 2016

    2016年4月   International Association of Advanced Materials Scientists Award for the year 2016

  • International Association of Advanced Materials Scientists Award for the year 2016 (IAAM SA-2016)

    2016年3月   International Association of Advanced Materials  

  • 9th World Biomaterials Congress Poster Award

    2012年6月  

  • JSPN-NRF Asian Science Seminar Seoul, Encouraging Prize

    2012年2月  

  • 高分子学会旭化成賞

    2011年10月   高分子学会  

  • 高分子学会旭化成賞

    2011年9月  

  • 日本バイオマテリアル学会科学奨励賞

    2009年11月  

  • AAP Winner, 米国歯周病学会

    2009年9月  

  • IUMRS-ICA2008 and MRS-J Encouraging Prize

    2008年12月  

  • PMI2 Connect-Research Co-operation Award 2008 from British Council

    2008年6月  

  • Nano tech 2007 国際ナノテクノロジー総合展・技術会議 Nano tech 大賞 バイオテクノロジー部門

    2007年12月  

  • 日本人工臓器学会第44回オリジナル賞

    2007年11月  

  • 日本表面科学会 平成19年度論文賞

    2007年11月  

  • 日本化学会若い世代の特別講演会賞

    2007年7月  

  • 日刊工業新聞第2回ものづくり連携大賞

    2007年2月  

  • 日本化学会北海道支部奨励賞

    2007年2月  

  • 高分子研究奨励賞

    2005年5月  

  • 日本再生医療学会総会「優秀演題賞」

    2004年6月  

  • 第83日本化学会春季年会2003 「講演奨励賞」受賞

    2003年3月  

  • 応用物理学会講演奨励賞

    2002年9月  

  • 第81日本化学会春季年会2002 「講演奨励賞」受賞

    2002年3月  

  • Korea Japan Joint Forum KJF2001 Organic Materials for Electronics and Photonics, Best Poster Award

    2001年9月  

▼全件表示

論文

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface 査読 国際誌

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   4 ( 5 )   1591 - 1597   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.8b00081

  • Poly(ω-methoxyalkyl acrylate)s Nonthrombogenic Polymer Family with Tunable Protein Adsorption 査読 国際誌

    18 ( 12 )   4214 - 4223   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of polyacrylates with different n-alkyl side chain lengths (1 to 6, and 12 carbons) and a ω-methoxy terminal group (poly(ω-methoxyalkyl acrylate): PMCxA) were prepared to study their nonthrombogenicity using human platelet adhesion, micro bicinchoninic acid (micro BCA) protein assay, and enzyme-linked immunosorbent assay (ELISA) tests. In all cases, human platelet adhesion was suppressed on the PMCxA-coated substrates, and the number of human platelets adhered to the PMC3A (poly(3-methoxypropyl acrylate))-coated surface was comparable to that of commercialized nonthrombogenic coating agent poly(2-methoxyethyl acrylate) (PMEA, equal to PMC2A). The amount of protein adsorbed onto the PMCxA was investigated by micro BCA using bovine serum albumin (BSA) and human fibrinogen (hFbn), revealing that PMC3A exhibited significantly high resistance to nonspecific BSA adsorption. Additionally, the amount of hFbn adsorbed onto the PMC3A was suppressed to the same extent as PMEA. The exposure degree of platelet adhesion sites in adsorbed hFbn was evaluated using an ELISA test, and the degree on the PMCxA with three to six methylene carbons was comparable to the PMEA. The hydration water structure in the hydrated PMCxA was also characterized using differential scanning calorimetry (DSC). The amount of intermediate water, which is the hydration water molecules that moderately interact with the polymer matrix, was maximum in the PMEA with two methylene run lengths, whereas the amount decreased by increasing the number of methyelnes in the side chain. The amount of adsorbed protein increased with a decrease in the amount of intermediate water, suggesting that the protein adsorption amount is tunable by simply changing the number of methylene carbons in the side chain. The present study revealed that poly(ω-methoxyalkyl acrylate)s are useful for blood-contacting medical devices, and PMC3A is the best mode of PMCxA to apply as an antiprotein adsorption coating agent.

    DOI: 10.1021/acs.biomac.7b01247

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion A Promising Material for Resorbable Vascular Grafts and Stents 査読 国際誌

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    Biomacromolecules   18 ( 11 )   3834 - 3843   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b01210

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester) A Candidate for Blood-Compatible Polymers 査読 国際誌

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    Biomacromolecules   18 ( 5 )   1609 - 1616   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b00221

  • Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces 査読 国際誌

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   2 ( 12 )   2122 - 2126   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.6b00415

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs 査読 国際誌

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    Biomacromolecules   17 ( 11 )   3808 - 3815   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.6b01340

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene 査読 国際誌

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   49 ( 21 )   8154 - 8161   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.6b01829

  • Regioselective Ring-Opening Metathesis Polymerization of 3-Substituted Cyclooctenes with Ether Side Chains. 査読 国際誌

    Shingo Kobayashi, Kousaku Fukuda, Maiko Kataoka, Masaru Tanaka

    Macromolecules   49 ( 7 )   2493 - 2501   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.6b00273

  • Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development 査読 国際誌

    Takashi Hoshiba, Takayuki Otaki, Eri Nemoto, Hiroka Maruyama, Masaru Tanaka

    ACS applied materials & interfaces   7 ( 32 )   18096 - 18103   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsami.5b05210

  • Evaluation of Factors To Determine Platelet Compatibility by Using Self-Assembled Monolayers with a Chemical Gradient 査読 国際誌

    Taito Sekine, Yusaku Tanaka, Chikako Sato, Masaru Tanaka, Tomohiro Hayashi

    Langmuir   31 ( 25 )   7100 - 7105   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.5b01216

  • Effect of local chain dynamics on a bioinert interface 査読 国際誌

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Tomoyasu Hirai, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    Langmuir   31 ( 12 )   3661 - 3667   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.5b00258

  • Effect of sodium chloride on hydration structures of PMEA and P(MPC- R -BMA) 査読 国際誌

    Shigeaki Morita, Masaru Tanaka

    Langmuir   30 ( 35 )   10698 - 10703   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la502550d

  • Characterization of the attachment mechanisms of tissue-derived cell lines to blood-compatible polymers 査読 国際誌

    Takashi Hoshiba, Mayo Nikaido, Masaru Tanaka

    Advanced Healthcare Materials   3 ( 5 )   775 - 784   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/adhm.201300309

  • How the brain differentiates human and monkey faces: Neuromagnetic evidence from spatiotemporal dynamics.

    Yamada E, Takeda A, Nakazono H, Tanaka M, Ogata K, Tobimatsu S

    Neuroscience   565   80 - 90   2025年1月   ISSN:0306-4522

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    記述言語:英語  

    DOI: 10.1016/j.neuroscience.2024.11.018

    PubMed

  • Self-Assembly and Drug Encapsulation Properties of Biocompatible Amphiphilic Diblock Copolymers.

    Yokota K, Usuda S, Nishimura T, Takahashi R, Taoka Y, Kobayashi S, Tanaka M, Matsumura K, Yusa SI

    Langmuir : the ACS journal of surfaces and colloids   2025年1月   ISSN:0743-7463

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.4c04048

    PubMed

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  • Relationship between maternal egg consumption during lactation and the risk of developing egg allergies in 12-month-old infants: A multicenter cohort study.

    Kishino S, Yonezawa K, Haruna M, Usui Y, Sasaki S, Fujita M, Matsuzaki M, Sato Y, Suetsugu Y, Ohori R, Tanaka M, Aoyama S

    Japan journal of nursing science : JJNS   22 ( 1 )   e12631   2025年1月   ISSN:1742-7932

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    記述言語:英語  

    DOI: 10.1111/jjns.12631

    PubMed

  • Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice.

    Li X, Ichiba Y, Watanabe T, Yoshino A, Cheng L, Nagasato Y, Takata F, Dohgu S, Iwasaki K, Tanaka M, Matsui T

    NPJ science of food   8 ( 1 )   114   2024年12月

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    記述言語:英語  

    DOI: 10.1038/s41538-024-00360-0

    PubMed

  • Association between early anti-cytomegalovirus therapy and the incidence of chronic graft-versus-host disease.

    Miyao K, Murata M, Nishida T, Ozawa Y, Uchida N, Fukuda T, Doki N, Eto T, Kawakita T, Mori Y, Takada S, Ohigashi H, Tanaka M, Kanda Y, Matsuoka KI, Ishimaru F, Atsuta Y, Kanda J, Terakura S, GVHD Working Group of the Japanese Society for Transplantation and Cellular Therapy

    International journal of hematology   2024年11月   ISSN:0925-5710

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    記述言語:英語  

    DOI: 10.1007/s12185-024-03871-4

    PubMed

  • B(12)-Catalyzed Carbonylation of Carbon Tetrahalides: Using a Broad Range of Visible Light to Access Diverse Carbonyl Compounds.

    Shichijo K, Tanaka M, Kametani Y, Shiota Y, Fujitsuka M, Shimakoshi H

    Chemistry (Weinheim an der Bergstrasse, Germany)   e202403663   2024年11月   ISSN:0947-6539

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    記述言語:英語  

    DOI: 10.1002/chem.202403663

    PubMed

  • Comparative outcomes of various transplantation platforms, highlighting haploidentical transplants with post-transplantation cyclophosphamide for adult T-cell leukaemia/lymphoma.

    Yoshimitsu M, Tanaka T, Nakano N, Kato K, Muranushi H, Tokunaga M, Ito A, Ishikawa J, Eto T, Morishima S, Kawakita T, Itonaga H, Uchida N, Tanaka M, Akizuki K, Ishitsuka K, Ohigashi H, Ota S, Ando T, Kanda Y, Fukuda T, Atsuta Y, Fuji S, ATL Working Group of the Japanese Society for Transplantation and Cellular Therapy

    British journal of haematology   2024年10月   ISSN:0007-1048

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    記述言語:英語  

    DOI: 10.1111/bjh.19835

    PubMed

  • The efficacy of wrapping with polyglycolic acid mesh and fibrin glue in preventing clinically relevant pancreatic fistula after minimally invasive distal pancreatectomy (WRAP Study): study protocol for a multicenter randomized controlled trial in Japan.

    Baba H, Oba A, Tanaka K, Miura T, Ban D, Edanami M, Ishikawa Y, Ohgi K, Tanaka H, Shintakuya R, Ikenaga N, Ijichi T, Kiya Y, Muranushi R, Yamaki S, Miyazaki N, Takeuchi S, Aoki S, Mizui T, Tanaka M, Ueda H, Dei H, Takami H, Okada K, Nakata K, Mataki Y, Osakabe H, Shibuya K, Hashimoto D, Inoue Y, Hirano S, Unno M, Esaki M, Kitago M, Akahoshi K, Sugiura T, Ebata T, Uemura K, Nakamura M, Otsuka T, Nagakawa Y, Fujii T, Satoi S, Takahashi Y

    BMC surgery   24 ( 1 )   314   2024年10月

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    記述言語:英語  

    DOI: 10.1186/s12893-024-02610-0

    PubMed

  • Dermoscopic Examination of Tinea Nigra on the Plantar Foot Unveils a Parallel Ridge Pattern Mimicking Acral-Lentiginous Melanoma(タイトル和訳中)

    Saikawa Mako, Kimura Utako, Ikari Yuka, Miyata Ayaka, Kaneko Takahide, Hiruma Masataro, Yaguchi Takashi, Tanaka Masaru, Takamori Kenji, Suga Yasushi

    Medical Mycology Journal   65 ( 4 )   103 - 106   2024年10月   ISSN:2185-6486

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    記述言語:英語   出版者・発行元:(一社)日本医真菌学会  

  • A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome 国際誌

    Najmina M., Kobayashi S., Shimazui R., Takata H., Shibata M., Ishibashi K., Kamizawa H., Kishimura A., Shiota Y., Ida D., Shimizu T., Ishida T., Katayama Y., Tanaka M., Mori T.

    Pharmaceutics   16 ( 10 )   2024年9月   ISSN:1999-4923

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Pharmaceutics  

    Background: Acrylamide polymers with zwitterionic carboxybetaine (CB) side groups have attracted attention as stealth polymers that do not induce antibodies when conjugated to proteins. However, they induce antibodies when modified onto liposomes. We hypothesized that antibodies are produced against polymer backbones rather than CB side groups. Objectives: In this study, we designed and synthesized a polymer employing CB in its main chain, poly(N-acetic acid-N-methyl-propyleneimine) (PAMPI), and evaluated the blood retention of PAMPI-modified liposomes in mice. Results: The non-fouling nature of PAMPI-modified liposomes estimated from serum protein adsorption was found to be not inferior to PCB- and PEG-modified liposomes. However, to our surprise, the PAMPI-modified liposomes showed an instantaneous clearance less than 1 h post-injection, comparable to the naked liposomes. Conclusions: The extent of the blood retention of polymer-modified liposomes cannot be predicted by their susceptibility to serum protein adsorption and semi-flexible conformation.

    DOI: 10.3390/pharmaceutics16101271

    Scopus

    PubMed

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  • Pronounced Cold Crystallization and Hydrogen Bonding Distortion of Water Confined in Microphases of Double Zwitterionic Block Copolymer Aqueous Solutions

    Higaki Y., Masuda T., Shiomoto S., Tanaka Y., Kiuchi H., Harada Y., Tanaka M.

    Langmuir   40 ( 37 )   19612 - 19618   2024年9月   ISSN:07437463

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Langmuir  

    Advanced materials leveraging water control are garnering considerable interest, with the state of water emerging as a critical aspect of material design. This study explored the impact of microphase separation on water using aqueous solutions of double zwitterionic diblock copolymers, specifically poly(carboxybetaine methacrylate) and poly(sulfobetaine methacrylate) (PCB2-b-PSB4). These copolymers form a mesoscale periodic ordered lattice structure consisting of two distinct aqueous phases. Through differential scanning calorimetry and X-ray emission spectroscopy, it was found that water in these PCB2-b-PSB4 aqueous solutions exhibits pronounced cold crystallization and subtle distortions in hydrogen-bonding configurations.

    DOI: 10.1021/acs.langmuir.4c02254

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  • Relation between the Water Content and Mechanical Properties of Hydrogels with Movable Cross-Links

    Nishida K., Ikura R., Yamaoka K., Urakawa O., Konishi T., Inoue T., Matsuba G., Tanaka M., Takashima Y.

    Macromolecules   2024年8月   ISSN:0024-9297 eISSN:1520-5835

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Macromolecules  

    To reveal the synergic effects of movable and reversible cross-links, we fabricated movable cross-linked hydrogels with hydrophobic acetylated cyclodextrins (CDs). The obtained hydrogels showed high toughness based on the broad range of relaxation times achieved by the high mobility of movable cross-links and reversible hydrophobic interaction. The high mobility of movable cross-links resulted from the lack of hydrogen bonds between the triacetylated γCD (TAcγCD) units and main chains. High mobility also occurred because TAcγCD units were not hydrated. The localization of hydration forms hydrophobic domains with the distribution of TAcγCD units. The hydrophobic domains also disperse the stress upon tensile deformation. The low water content (Wc = 15 wt %) achieved further high toughness (36.8 MJ·m-3) by the triple-synergic effects of movable cross-links, reversible hydrophobic interaction, and craze/fibril-like structures upon deformation. The mobility of movable cross-links and the reformation of reversible hydrophobic interaction achieved high self-restoring properties.

    DOI: 10.1021/acs.macromol.4c00732

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  • Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions

    Okada M., Xie S.C., Kobayashi Y., Yanagimoto H., Tsugawa D., Tanaka M., Nakano T., Fukumoto T., Matsumoto T.

    Advanced Healthcare Materials   13 ( 19 )   e2304616   2024年7月   ISSN:21922640

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    記述言語:英語   出版者・発行元:Advanced Healthcare Materials  

    Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.

    DOI: 10.1002/adhm.202304616

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  • Rotational Dynamics of Water near Osmolytes by Molecular Dynamics Simulations

    Higuchi Y., Saleh M.A., Anada T., Tanaka M., Hishida M.

    Journal of Physical Chemistry B   128 ( 20 )   5008 - 5017   2024年5月   ISSN:15206106

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Physical Chemistry B  

    The behavior of water molecules around organic molecules has attracted considerable attention as a crucial factor influencing the properties and functions of soft matter and biomolecules. Recently, it has been suggested that the change in protein stability upon the addition of small organic molecules (osmolytes) is dominated by the change in the water dynamics caused by the osmolyte, where the dynamics of not only the directly interacting water molecules but also the long-range hydration layer affect the protein stability. However, the relation between the long-range structure of hydration water in various solutions and the water dynamics remains unclear at the molecular level. We performed density-functional tight-binding molecular dynamics simulations to elucidate the varying rotational dynamics of water molecules in 15 osmolyte solutions. A positive correlation was observed between the rotational relaxation time and our proposed normalized parameter obtained by dividing the number of hydrogen bonds between water molecules by the number of nearest-neighbor water molecules. For the 15 osmolyte solutions, an increase or a decrease in the value of the normalized parameter for the second hydration shell tended to result in water molecules with slow and fast rotational dynamics, respectively, thus illustrating the importance of the second hydration shell for the rotational dynamics of water molecules. Our simulation results are anticipated to advance the current understanding of water dynamics around organic molecules and the long-range structure of water molecules.

    DOI: 10.1021/acs.jpcb.3c08470

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  • Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain

    Zuo S., Wang Z., Jiang X., Zhao Y., Wen P., Wang J., Li J., Tanaka M., Dan S., Zhang Y., Wang Z.

    Biomaterials   309   122603 - 122603   2024年5月   ISSN:0142-9612

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomaterials  

    Sympathetic nerves play a pivotal role in promoting tumor growth through crosstalk with tumor and stromal cells. Chemotherapy exacerbates the infiltration of sympathetic nerves into tumors, thereby providing a rationale for inhibiting sympathetic innervation to enhance chemotherapy. Here, we discovered that doxorubicin increases the density and activity of sympathetic nerves in breast cancer mainly by upregulating the expression of nerve growth factors (NGFs) in cancer cells. To address this, we developed a combination therapy by co-encapsulating small interfering RNA (siRNA) and doxorubicin within breast cancer-targeted poly (lactic-co-glycolic acid) (PLGA) nanoparticles, aiming to suppress NGF expression post-chemotherapy. Incorporating NGF blockade into the nanoplatform for chemotherapy effectively mitigated the chemotherapy-induced proliferation of sympathetic nerves. This not only bolstered the tumoricidal activity of chemotherapy, but also amplified its stimulatory impact on the antitumor immune response by increasing the infiltration of immunostimulatory cells into tumors while concurrently reducing the frequency of immunosuppressive cells. Consequently, the combined nanodrug approach, when coupled with anti-PD-L1 treatment, exhibited a remarkable suppression of primary and deeply metastatic tumors with minimal systematic toxicity. Importantly, the nanoplatform relieved chemotherapy-induced peripheral neuropathic pain (CIPNP) by diminishing the expression of pain mediator NGFs. In summary, this research underscores the significant potential of NGF knockdown in enhancing immunochemotherapy outcomes and presents a nanoplatform for the highly efficient and low-toxicity treatment of breast cancer.

    DOI: 10.1016/j.biomaterials.2024.122603

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  • Development of stealth nanoparticles coated with poly(2-methoxyethyl vinyl ether) as an alternative to poly(ethylene glycol)

    Fujiura K., Naito M., Tanaka Y., Tanaka M., Nakanishi Y., Ejima H., Negishi L., Kujirai T., Kurumizaka H., Ohta S., Miyata K.

    Journal of Applied Polymer Science   141 ( 11 )   2024年3月   ISSN:00218995

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    出版者・発行元:Journal of Applied Polymer Science  

    Poly(ethylene glycol) (PEG) modification, also known as PEGylation, has been extensively used to improve the stability of nanoparticles for nanomedical applications. However, PEG exhibits antigenicity in some formulations, motivating researchers to explore alternative polymers. Herein, poly(vinyl ether) (PVE) derivatives are highlighted as promising alternatives to PEG because they form intermediate water molecules that suppress non-specific protein adsorption and platelet adhesion to the material surface. We prepared a water-soluble PVE derivative, poly(2-methoxyethyl vinyl ether) (PMOVE), and utilized it as a surface modifier for gold nanoparticles (AuNPs) as model nanoparticles. PMOVE with a thiol terminus was synthesized and confirmed to form an intermediate water molecule using differential scanning calorimetry. Similar to the synthesis of PEGylated AuNPs (PEG-AuNPs), PMOVE-modified AuNPs (PMOVE-AuNPs) were successfully fabricated with an appreciably high density of PMOVE palisades via a thiol-gold coordination reaction. Similar to PEG-AuNPs, PMOVE-AuNPs showed reduced serum protein adsorption and prolonged blood circulation. Additionally, no significant cytotoxicity was observed after incubation of a murine macrophage cell line, RAW264.7, with PMOVE-AuNPs. Our results indicate that the PMOVE modification increases the stealthiness of nanoparticles that is equivalent to that achieved by PEGylation.

    DOI: 10.1002/app.55044

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  • Detailed dynamical features of the slow hydration water in the vicinity of poly(ethylene oxide) chains

    Kikuchi T., Tominaga T., Murakami D., de Souza N.R., Tanaka M., Seto H.

    Journal of Chemical Physics   160 ( 6 )   2024年2月   ISSN:0021-9606 eISSN:1089-7690

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Chemical Physics  

    Poly(ethylene oxide) (PEO) is a well-known biocompatible polymer and has widely been used for medical applications. Recently, we have investigated the dynamic behavior of hydration water in the vicinity of PEO chains at physiological temperature and shown the presence of slow water with diffusion coefficient one order of magnitude less than that of bulk water. This could be evidence for the intermediate water that is critical for biocompatibility; however, its detailed dynamical features were not established. In this article, we analyze the quasi-elastic neutron scattering from hydration water through mode distribution analysis and present a microscopic picture of hydration water as well as its relation to cold crystallization.

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  • Hydrolyzable and biocompatible aliphatic polycarbonates with ether-functionalized side chains attached via amide linkers

    Fukushima K., Hakozaki S., Lang R., Haga Y., Nakai S., Narumi A., Tanaka M., Kato T.

    Polymer Journal   56 ( 4 )   431 - 442   2024年1月   ISSN:0032-3896 eISSN:1349-0540

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Polymer Journal  

    Abstract

    Investigating polymer degradation mechanisms enables the establishment of controlled degradation techniques for the development of sustainable and recyclable materials. Hydration can play a crucial role in controlling the hydrolysis of polymers. Here, ether-functionalized aliphatic polycarbonates (APCs) susceptible to nonenzymatic hydrolysis were developed for application as biocompatible biomaterials. Among these polymers, those grafted with 2-methoxyethyl and 3-methoxypropyl side chains via an amide group were highly wettable, strongly interacted with water, and experienced almost complete hydrolysis in phosphate-buffered saline over 30 days, which was attributed to the hydrogen bonding between water and the amide/methoxy groups. In an alkaline medium, all amide-linked APCs were completely hydrolyzed within 30 days, regardless of the side-chain structure. In contrast, the nonamide-linked APCs and a representative aliphatic polycarbonate, poly(trimethylene carbonate), were minimally degraded in the buffer and experienced <31% degradation under alkaline conditions. The APC with the 3-methoxypropyl side chain exhibited platelet adhesion properties comparable to those of ether-functionalized APCs previously reported as blood-compatible polymers. Thus, our results demonstrate the effects of an amide linker on the hydration and hydrolytic properties of APCs and can help establish new design concepts for degradable polymers.

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    その他リンク: https://www.nature.com/articles/s41428-023-00874-6

  • Suspension Culture System for Isolating Cancer Spheroids using Enzymatically Synthesized Cellulose Oligomers 国際誌

    Hayakawa N., Nishiura M., Anada T., Kobayashi S., Sawada T., Serizawa T., Tanaka M.

    ACS Applied Bio Materials   7 ( 1 )   306 - 314   2024年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Applied Bio Materials  

    Isolating cancer cells from tissues and providing an appropriate culture environment are important for a better understanding of cancer behavior. Although various three-dimensional (3D) cell culture systems have been developed, techniques for collecting high-purity spheroids without strong stimulation are required. Herein, we report a 3D cell culture system for the isolation of cancer spheroids using enzymatically synthesized cellulose oligomers (COs) and demonstrate that this system isolates only cancer spheroids under coculture conditions with normal cells. CO suspensions in a serum-containing cell culture medium were prepared to suspend cells without settling. High-purity cancer spheroids could be separated by filtration without strong stimulation because the COs exhibited antibiofouling properties and a viscosity comparable to that of the culture medium. When human hepatocellular carcinoma (HepG2) cells, a model for cancer cells, were cultured in the CO suspensions, they proliferated clonally and efficiently with time. In addition, only developed cancer spheroids from HepG2 cells were collected in the presence of normal cells by using a mesh filter with an appropriate pore size. These results indicate that this approach has potential applications in basic cancer research and cancer drug screening.

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  • Role of intermediate water in alleviating postsurgical intrapericardial adhesion

    Suzuki T., Konishi H., Suzuki A., Katsumata T., Fukuda Y., Miyamoto K., Ise T., Tanaka Y., Yamamoto A., Wen P., Shiomoto S., Tanaka M., Nemoto S.

    Surgery Today   2024年   ISSN:09411291

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    記述言語:英語   出版者・発行元:Surgery Today  

    Purpose: Various polymers have been used as postsurgical antiadhesive materials; however, the mechanisms underlying their efficacy remain unclear. Intermediate water has been found to prevent the adhesion between polymer molecules and proteins or cells. The present study investigated the role of intermediate water retained in the polymer in alleviating postsurgical pericardial adhesion. Methods: Hydrophobic fabrics were prepared using biodegradable polyglycolic acid. To add intermediate water, the fabric fibers were coated with poly(oxyethylene)oleyl ethers. Intermediate water in the hydrated state was detected by a thermal analysis for each material, and cell attachment to the fibers with or without coating was observed in vitro. Using a canine model of postsurgical pericardial adhesion, the severity of adhesion was examined along with a histological assessment during treatment, with or without fabric coating. Results: Intermediate water was detected in the coating materials but not in polyglycolic acid. Coating significantly reduced the cell attachment to the fibers. Coating also alleviated adhesion by reducing inflammation in the fibrous layer and replacing the fabric and granulomas that develop around the surgical sutures in the pericardial space. Conclusions: Intermediate water in the hydrated polymer of anti-adhesives may play an important role in alleviating postoperative pericardial adhesion.

    DOI: 10.1007/s00595-024-02953-4

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  • Neurophysiological markers of early cognitive decline in older adults: a mini-review of electroencephalography studies for precursors of dementia.

    Tanaka M, Yamada E, Mori F

    Frontiers in aging neuroscience   16   1486481   2024年   ISSN:1663-4365

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    記述言語:英語  

    DOI: 10.3389/fnagi.2024.1486481

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  • Effects of hydration water on bioresponsiveness of polymer interfaces revealed by analysis of linear and cyclic polymer-grafted substrates

    Nishimura S.N., Kurahashi N., Shiomoto S., Harada Y., Tanaka M.

    Soft Matter   20 ( 47 )   9454 - 9463   2024年   ISSN:1744-683X eISSN:1744-6848

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Soft Matter  

    Given that the hydration water of polymer matrices may differ from that of outermost polymer surfaces, processes at biomaterial-biofluid interfaces and role of hydration water therein cannot be adequately examined using most conventional characterization methods. To bridge this gap, a gold substrate was herein modified with linear and cyclic poly(2-methoxyethyl acrylate) to prepare gl-PMEA and gc-PMEA surfaces, respectively, as models for the outermost surfaces of blood-contacting medical devices. Both surfaces suppressed the adhesion of human platelets but differed in the adhesion behaviors of normal and tumor cells despite having the same areal density of fixed-end units. The surfaces were analyzed using quartz crystal microbalance (QCM), frequency modulation atomic force microscopy (FM-AFM), and X-ray emission spectroscopy (XES) measurements under wet conditions to clarify the relationship between bioresponsivity and hydration water. QCM measurements provided evidence that both grafted-PMEA were hydrated. FM-AFM observations revealed that the swelling layer was thicker for gc-PMEA. To rationalize the differences in the surface hydration states, we performed XES measurements under conditions enabling control over the number of hydration water molecules. In the low-water-content region, hydrogen bonds or interactions between water molecules developed in the vicinity of gl-PMEA but not gc-PMEA. Thus, the initial hydration behavior of the gc-PMEA surface, which promoted intermediate water formation, was different from that of the gl-PMEA surface. The results suggested that the adjustment and optimization of the hydration state of outermost biomaterial surfaces enable the control of bioresponsivity, including the selective isolation of tumor cells.

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  • Optically Transparent and Color-Stable Elastomer with Structural Coloration under Elongation

    Miyake D., He J., Asai F., Hara M., Seki T., Nishimura S.N., Tanaka M., Takeoka Y.

    Langmuir   39 ( 49 )   17844 - 17852   2023年12月   ISSN:07437463

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    記述言語:英語   出版者・発行元:Langmuir  

    Optically transparent and colored elastomers with high toughness are expected to play an important role in the construction of advanced medical materials, wearable displays, and soft robots. In this study, we found that composite elastomers consisting of amorphous SiO2 particles homogeneously dispersed in high concentrations within a biocompatible acrylic polymer network exhibit optical transparency and bright structural colors. In the composite elastomers, the system in which the SiO2 particles form a colloidal amorphous array hardly changes its structural color hue despite deformation due to elongation. Furthermore, the composite elastomer of the SiO2 particles with the acrylic polymer network also results in high mechanical toughness. In summary, we have shown that the elastomer that exhibits fade-resistant structural coloration formed from safe materials can combine stable coloration and mechanical strength independent of their shape. This is expected to have new potential in future technologies to support our daily life.

    DOI: 10.1021/acs.langmuir.3c02442

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  • ナノバイオ界面水制御による細胞接着性/非接着性合成高分子の設計

    田中 賢

    Drug Delivery System   38 ( 5 )   404 - 415   2023年11月   ISSN:09135006 eISSN:18812732

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    記述言語:日本語   出版者・発行元:日本DDS学会  

    材料が生体組織液に接触すると直ちに水が材料表面に吸着する。水分子は、ナノバイオ界面におけるタンパク質吸着/脱離、細胞接着/非接着現象に影響を与える。界面現象を明らかにするためには、水和した材料の物理化学的な物性を理解することが重要である。本稿では、最近の筆者らの研究例、例えば、ポリ(2-メトキシエチルアクリレート)(PMEA)、PMEA誘導体、双性イオン型高分子、ポリエチレングリコール、ポリオキサゾリンなどの合成高分子、また、核酸、タンパク質、多糖などの生体高分子に含水した水の状態について議論する。水の状態は、熱分析や分光により解析を行った。界面に形成される特定の水の状態:中間水が、タンパク質吸着/細胞接着に大きな影響を与えることや機能性合成高分子の設計につながることを見出した。

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  • Assessing the variability of tissue-free water tritium and non-exchangeable organically bound tritium in pine needles in Fukushima using atmospheric titrated water vapor.

    Hirao S, Kakiuchi H, Akata N, Tamari T, Sugihara S, Shima N, Tanaka M

    The Science of the total environment   168173   2023年10月   ISSN:0048-9697

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  • Altering the bio-inert properties of surfaces by fluorinated copolymers of mPEGMA

    Koguchi, R; Jankova, K; Tanaka, Y; Yamamoto, A; Murakami, D; Yang, QZ; Ameduri, B; Tanaka, M

    BIOMATERIALS ADVANCES   153   213573 - 213573   2023年10月   ISSN:2772-9508 eISSN:2772-9508

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomaterials Advances  

    Hydrophilic materials display “bio-inert properties”, meaning that they are less recognized as foreign substances by proteins and cells. Such materials are often water soluble; therefore, one general approach to enable the use of these materials in various applications deals with copolymerizing hydrophilic monomers with hydrophobic ones to facilitate such resulting copolymers water insoluble. However, reducing the hydrophilic monomer amount may reduce the bio-inert properties of the material. The decrease in bio-inert properties can be avoided when small amounts of fluorine are used in copolymers with hydrophilic monomers, as presented in this article. Even in small quantities (7.9 wt%), the fluorinated monomer, 1,1,1,3,3,3-hexafluoropropan-2-yl 2-fluoroacrylate (FAHFiP), contributed to the improved hydrophobicity of the polymers of the long side-chain poly(ethylene glycol) methyl ether methacrylate (mPEGMA) bearing nine ethylene glycol units turning them water insoluble. As evidenced by the AFM deformation image, a phase separation between the FAHFiP and mPEGMA domains was observed. The copolymer with the highest amount of the fluorinated monomer (66.2 wt%) displayed also high (82 %) FAHFiP amount at the polymer–water interface. In contrast, the hydrated sample with the lowest FAHFiP/highest mPEGMA amount was enriched of three times more hydrophilic domains at the polymer–water interface compared to that of the sample with the highest FAHFiP content. Thus, by adding a small FAHFiP amount to mPEGMA copolymers, water insoluble in the bulk too, could be turned highly hydrophilic at the water interface. The high content of intermediate water contributed to their excellent bio-inert properties. Platelet adhesion and fibrinogen adsorption on their surfaces were even more decreased as compared to those on poly(2-methoxyethyl acrylate), which is typically used in medical devices.

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  • Organocatalyzed ring-opening reactions of ?-carbonyl-substituted e-caprolactones

    Ota, T; Montagna, V; Higuchi, Y; Kato, T; Tanaka, M; Sardon, H; Fukushima, K

    RSC ADVANCES   13 ( 40 )   27764 - 27771   2023年9月   eISSN:2046-2069

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:RSC Advances  

    Side-chain-functionalized aliphatic polyesters are promising as functional biodegradable polymers. We have investigated ring-opening reactions of γ-carbonyl-substituted ϵ-caprolactones (gCCLs) to obtain poly(ϵ-caprolactone) (PCL) analogues. Organic catalysts and Sn(Oct)2 often used for the ring-opening polymerization (ROP) of ϵ-caprolactone (CL) have been explored to find the conditions for the formation of polymeric products of gCCLs. We confirmed the consumption of gCCLs in all catalyzed reactions. However, chain propagation hardly occurs, as the propagating species are preferentially transformed to α-substituted five-membered lactones when the substituents are linked by ester or not sterically hindered. Intramolecular cyclization to form thermodynamically stable five-membered lactones releases alcohols and amines, serving as nucleophiles for the subsequent ring opening of other gCCLs. Thus, apparent chain reactions are realized for continuous consumption of gCCLs. The reaction preference remains unchanged independent of the catalysts, although the reactions of the amide-linked gCCLs by acidic catalysts are slightly mitigated. Finally, copolymerization of CL and a gCCL catalyzed by diphenyl phosphate has been investigated, which enables the chain propagation reaction to yield the linear oligomers of PCL analogues containing up to 16 mol% of gCCL units. This study contributes to understanding the chemistry of ring-opening reactions of substituted lactones for designing functional degradable polymers.

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  • The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update

    Nishimura S.N., Tanaka M.

    Bulletin of the Chemical Society of Japan   96 ( 9 )   1052 - 1070   2023年9月   ISSN:0009-2673 eISSN:1348-0634

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Bulletin of the Chemical Society of Japan  

    Polymeric biomaterials are often used in water and hydration water molecules with different mobilities, such as non-freezing water, intermediate water, and free water, are formed on their surfaces. These water molecules affect biological responses between the biomaterials and biofluids. It is challenging to control the state of hydration waters by tuning chemical structures of the polymers toward advance of medical fields. This review describes and updates syntheses, analyses, and applications of the polymeric biomaterials based on the intermediate water concept. The concept provides significant opportunities for pioneering polymeric biomaterials.

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  • Cellular characterization of hiPS CMs cultured on PMEA analogous polymers with different bound water content 査読

    栗田 寛子, 小林 慎吾, 穴田 貴久, 田中 賢, 東藤 貢

    九州大学大学院総合理工学報告   45 ( 1 )   1 - 6   2023年9月   ISSN:13467883

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:九州大学大学院総合理工学府  

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  • Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review

    Kumar, A; Sood, A; Agrawal, G; Thakur, S; Thakur, VK; Tanaka, M; Mishra, YK; Christie, G; Mostafavi, E; Boukherroub, R; Hutmacher, DW; Han, SS

    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   247   125606   2023年8月   ISSN:0141-8130 eISSN:1879-0003

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    記述言語:英語   出版者・発行元:International Journal of Biological Macromolecules  

    Nature-derived or biologically encouraged hydrogels have attracted considerable interest in numerous biomedical applications owing to their multidimensional utility and effectiveness. The internal architecture of a hydrogel network, the chemistry of the raw materials involved, interaction across the interface of counter ions, and the ability to mimic the extracellular matrix (ECM) govern the clinical efficacy of the designed hydrogels. This review focuses on the mechanistic viewpoint of different biologically driven/inspired biomacromolecules that encourages the architectural development of hydrogel networks. In addition, the advantage of hydrogels by mimicking the ECM and the significance of the raw material selection as an indicator of bioinertness is deeply elaborated in the review. Furthermore, the article reviews and describes the application of polysaccharides, proteins, and synthetic polymer-based multimodal hydrogels inspired by or derived from nature in different biomedical areas. The review discusses the challenges and opportunities in biomaterials along with future prospects in terms of their applications in biodevices or functional components for human health issues. This review provides information on the strategy and inspiration from nature that can be used to develop a link between multimodal hydrogels as the main frame and its utility in biomedical applications as the primary target.

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    PubMed

  • New techniques for jet calibration with the ATLAS detector

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Vasquez, GA; Vazeille, F; Furelos, DV; Schroeder, TV; Veatch, J; Vecchio, V; Veen, MJ; Veloce, LM; Veloso, F; Veneziano, S; Ventura, A; Venturi, N; Verbytskyi, A; Vercesi, V; Verducci, M; Infante, CMV; Vergis, C; Verkerke, W; Vermeulen, AT; Vermeulen, JC; Vetterli, MC; Maira, NV; Pinto, MVB; Vickey, T; Boeriu, OEV; Viehhauser, GHA; Vigani, L; Villa, M; Perez, MV; Vilucchi, E; Vincter, MG; Virdee, GS; Vishwakarma, A; Vittori, C; Vivarelli, ; Vogel, M; Vokac, P; von Buddenbrock, SE; Von Toerne, E; Vorobel, V; Vorobev, K; Vos, M; Vossebeld, JH; Vozak, M; Vranjes, N; Milosavljevic, MV; Vreeswijk, M; Vuillermet, R; Vukotic, ; Wagner, P; Wagner, W; Wagner-Kuhr, J; Wahdan, S; Wahlberg, H; Walbrecht, VM; Walder, J; Walker, R; Walker, SD; Walkowiak, W; Wallangen, ; Wang, AM; Wang, AZ; Wang, C; Wang, F; Wang, H; Wang, J; Wang, P; Wang, Q; Wang, RJ; Wang, R; Wang, SM; Wang, WT; Wang, W; Wang, WX; Wang, Y; Wang, Z; Wanotayaroj, C; Warburton, A; Ward, CP; Wardrope, DR; Warrack, N; Washbrook, A; Watson, AT; Watson, MF; Watts, G; Waugh, BM; Webb, AF; Webb, S; Weber, C; Weber, MS; Weber, SA; Weber, SM; Weidberg, AR; Weingarten, J; Weirich, M; Weiser, C; Wells, PS; Wenaus, T; Wengler, T; Wenig, S; Wermes, N; Werner, MD; Wessels, M; Weston, TD; Whalen, K; Whallon, NL; Wharton, AM; White, AS; White, A; White, MJ; Whiteson, D; Whitmore, BW; Wiedenmann, W; Wiel, C; Wielers, M; Wieseotte, N; Wiglesworth, C; Wiik-Fuchs, LAM; Wilkens, HG; Wilkins, LJ; Williams, HH; Williams, S; Willis, C; Willocq, S; Wingerter-Seez, ; Winkels, E; Winklmeier, F; Winston, OJ; Winter, BT; Wittgen, M; Wobisch, M; Wolf, A; Wolf, TMH; Wolff, R; Wolker, R; Wollrath, J; Wolter, MW; Wolters, H; Wong, VWS; Woods, NL; Worm, SD; Wosiek, BK; Wozniak, KW; Wraight, K; Wu, SL; Wu, X; Wu, Y; Wyatt, TR; Wynne, BM; Xella, S; Xi, Z; Xia, L; Xiao, X; Xiotidis, ; Xu, D; Xu, H; Xu, L; Xu, T; Xu, W; Xu, Z; Yabsley, B; Yacoob, S; Yajima, K; Yallup, DP; Yamaguchi, N; Yamaguchi, Y; Yamamoto, A; Yamatani, M; Yamazaki, T; Yamazaki, Y; Yan, Z; Yang, HJ; Yang, HT; Yang, S; Yang, T; Yang, X; Yang, Y; Yao, WM; Yap, YC; Yasu, Y; Yatsenko, E; Ye, H; Ye, J; Ye, S; Yeletskikh, ; Yexley, MR; Yigitbasi, E; Yorita, K; Yoshihara, K; Young, CJS; Young, C; Yu, J; Yuan, R; Yue, X; Zaazoua, M; Zabinski, B; Zacharis, G; Zaffaroni, E; Zahreddine, J; Zaitsev, AM; Zakareishvili, T; Zakharchuk, N; Zambito, S; Zanzi, D; Zaplatilek, O; Zaripovas, DR; Zeissner, S; Zeitnitz, C; Zemaityte, G; Zeng, JC; Zenin, O; Zenis, T; Zerwas, D; Zgubic, M; Zhang, B; Zhang, DF; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, R; Zhang, S; Zhang, X; Zhang, Y; Zhang, Z; Zhao, P; Zhao, Z; Zhemchugov, A; Zheng, Z; Zhong, D; Zhou, B; Zhou, C; Zhou, MS; Zhou, M; Zhou, N; Zhou, Y; Zhu, CG; Zhu, C; Zhu, HL; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zhulanov, ; Zieminska, D; Zimine, N; Zimmermann, S; Zinonos, Z; Ziolkowski, M; Zivkovic, L; Zobernig, G; Zoccoli, A; Zoch, K; Zorbas, TG; Zou, R; Zwalinski, L

    EUROPEAN PHYSICAL JOURNAL C   83 ( 8 )   2023年8月   ISSN:1434-6044 eISSN:1434-6052

  • Microphase separation of double-hydrophilic poly(carboxybetaine acrylate)-poly(2-methoxyethyl acrylate) block copolymers in water

    Higaki, Y; Toyama, H; Masuda, T; Kobayashi, S; Tanaka, M

    POLYMER JOURNAL   55 ( 12 )   1357 - 1365   2023年8月   ISSN:0032-3896 eISSN:1349-0540

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Polymer Journal  

    The microphase separation of double-hydrophilic block copolymers in water is of interest when these copolymers are utilized as molecular assemblies with mesoscale aqueous compartments. Diblock copolymers composed of a water-soluble zwitterionic polymer, poly(carboxybetaine acrylate) (PCBA2), and a hydrophilic water-insoluble nonionic polymer, poly(2-methoxyethyl acrylate) (PMEA), (PCBA2n-b-PMEAm) were synthesized, and their assembly characteristics were investigated in aqueous solutions. Well-defined PCBA2n-b-PMEAm block copolymers were synthesized by the reversible addition–fragmentation chain transfer polymerization of a carboxybetaine acrylate modified with a tert-butyl group and 2-methoxyethyl acrylate followed by tert-butyl group cleavage. PCBA2n-b-PMEAm produced particles in dilute aqueous solutions and microphase-separated structures in concentrated aqueous solutions. The hydrodynamic radius of the particles and the microphase-separated structure were associated with the block copolymer composition and degree of polymerization of the PMEA chain. The molecular assembly behavior was tolerant to NaCl concentration, providing molecular design guidelines for the use of double-hydrophilic microphase-separated compartments in physiological environments.

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  • Stealth and pseudo-stealth nanocarriers 査読 国際共著

    Wen, PY; Ke, WD; Dirisala, A; Toh, K; Tanaka, M; Li, JJ

    ADVANCED DRUG DELIVERY REVIEWS   198   114895 - 114895   2023年7月   ISSN:0169-409X eISSN:1872-8294

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Advanced Drug Delivery Reviews  

    The stealth effect plays a central role on capacitating nanomaterials for drug delivery applications through improving the pharmacokinetics such as blood circulation, biodistribution, and tissue targeting. Here based on a practical analysis of stealth efficiency and a theoretical discussion of relevant factors, we provide an integrated material and biological perspective in terms of engineering stealth nanomaterials. The analysis surprisingly shows that more than 85% of the reported stealth nanomaterials encounter a rapid drop of blood concentration to half of the administered dose within 1 h post administration although a relatively long β-phase is observed. A term, pseudo-stealth effect, is used to delineate this common pharmacokinetics behavior of nanomaterials, that is, dose-dependent nonlinear pharmacokinetics because of saturating or depressing bio-clearance of reticuloendothelial system (RES). We further propose structural holism can be a watershed to improve the stealth effect; that is, the whole surface structure and geometry play important roles, rather than solely relying on a single factor such as maximizing repulsion force through polymer-based steric stabilization (e.g., PEGylation) or inhibiting immune attack through a bio-inspired component. Consequently, engineering delicate structural hierarchies to minimize attractive binding sites, that is, minimal charges/dipole and hydrophobic domain, becomes crucial. In parallel, the pragmatic implementation of the pseudo-stealth effect and dynamic modulation of the stealth effect are discussed for future development.

    DOI: 10.1016/j.addr.2023.114895

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  • Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes

    Kobayashi, S; Tanaka, M

    MOLECULAR SYSTEMS DESIGN & ENGINEERING   8 ( 8 )   960 - 991   2023年6月   ISSN:2058-9689

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Molecular Systems Design and Engineering  

    Ring-opening metathesis polymerisation (ROMP) has become a popular method for synthesising complex functional polymers owing to the high functional group tolerance of metathesis catalysts. In recent years, ROMP has emerged as an indispensable approach for the design and synthesis of polymeric biomaterials, allowing for precise control of polymer structure and introduction of complex polar functional groups that are challenging to access through conventional polymerisation methods. In this review, we present examples of precision polymer synthesis with polar functional groups and their utilisation as soft-biomaterials in biotechnology and biomedical fields. Specifically, we focus on two approaches: the underexplored ROMP of functionalised monocyclic alkenes and the dominant methods of synthesising biomaterials using functionalised norbornene.

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  • Effect of titanium-doped bioactive glass on poly(2-hydroxyethyl methacrylate) hydrogel composites: Bioactivity, intermediate water, cell proliferation, and adhesion force

    Mabrouk, M; Beherei, HH; Shiomoto, S; Tanaka, Y; Osama, L; Tanaka, M

    CERAMICS INTERNATIONAL   49 ( 9 )   13469 - 13481   2023年5月   ISSN:0272-8842 eISSN:1873-3956

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Ceramics International  

    The intermediate water (IW) concept has been hypothesized to predict the biocompatibility of polymers and inorganic materials. This study, for the first time, prepared the composite biomaterials of poly(2-hydroxyethyl methacrylate) (PHEMA)/titanium-doped bioactive glasses (BGT) for bone regeneration by applying the IW concept. The homogeneous distribution of BGT and the mechanical stability of the composites were confirmed using X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectrometry, and rheological characterization. In vitro tests with immersion in simulated body fluid showed that titanium doping improved the biomineralization properties. The IW level ranged from 10.4 wt% with 0% titanium doped to 25.6 wt% with 7.5% titanium doped. Cell viability tests on osteosarcoma cells revealed that the growth rate increased with increasing titanium concentration, reaching up to 150%. Based on single-cell force spectroscopy, an appropriate titanium concentration for cell adhesion was estimated to be 5%. The hydrated PHEMA gels with 5% BGT exhibited a high IW level of 19.3% and less hydrophilic wettability than the gels without titanium or with 10% BGT. The IW concept proved to be useful for predicting the bone regeneration potential on the interfaces of the PHEMA/BGT composite hydrogels.

    DOI: 10.1016/j.ceramint.2022.12.221

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  • Characterization of polypropyleneimine as an alternative transfection reagent 査読

    Saeki, R; Kobayashi, S; Shimazui, R; Nii, T; Kishimura, A; Mori, T; Tanaka, M; Katayama, Y

    ANALYTICAL SCIENCES   39 ( 6 )   1015 - 1020   2023年3月   ISSN:0910-6340 eISSN:1348-2246

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Analytical Sciences  

    Polypropyleneimine (PPI) was examined as a transfection reagent comparing with most widely used polymer, polyethyleneimine (PEI). PPI had better responsiveness to the endosomal pH and showed more condensation ability of plasmid DNA than PEI. Although the cytotoxicity of PPI was somewhat higher than PEI, the transfection efficacy of PPI was comparable with PEI or higher than PEI in some cell line. Thus, PPI would be an alternative transfection reagent. Graphical abstract: [Figure not available: see fulltext.].

    DOI: 10.1007/s44211-023-00284-x

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    その他リンク: https://link.springer.com/article/10.1007/s44211-023-00284-x/fulltext.html

  • Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates 国際誌

    Nomura, M; Yokoyama, Y; Yoshimura, D; Minagawa, Y; Yamamoto, A; Tanaka, Y; Sekiguchi, N; Marukawa, D; Ichihara, M; Itakura, H; Matsumoto, K; Morimoto, Y; Tomihara, H; Inoue, A; Ogino, T; Miyoshi, N; Takahashi, H; Takahashi, H; Uemura, M; Kobayashi, S; Mizushima, T; Anada, T; Mori, M; Doki, Y; Tanaka, M; Eguchi, H; Yamamoto, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   24 ( 4 )   2023年2月   ISSN:1661-6596 eISSN:1422-0067

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Molecular Sciences  

    Here we aimed to establish a simple detection method for detecting circulating tumor cells (CTCs) in the blood sample of colorectal cancer (CRC) patients using poly(2-methoxyethyl acrylate) (PMEA)-coated plates. Adhesion test and spike test using CRC cell lines assured efficacy of PMEA coating. A total of 41 patients with pathological stage II-IV CRC were enrolled between January 2018 and September 2022. Blood samples were concentrated by centrifugation by the OncoQuick tube, and then incubated overnight on PMEA-coated chamber slides. The next day, cell culture and immunocytochemistry with anti-EpCAM antibody were performed. Adhesion tests revealed good attachment of CRCs to PMEA-coated plates. Spike tests indicated that ~75% of CRCs from a 10-mL blood sample were recovered on the slides. By cytological examination, CTCs were identified in 18/41 CRC cases (43.9%). In cell cultures, spheroid-like structures or tumor-cell clusters were found in 18/33 tested cases (54.5%). Overall, CTCs and/or growing circulating tumor cells were found in 23/41 CRC cases (56.0%). History of chemotherapy or radiation was significantly negatively correlated with CTC detection (p = 0.02). In summary, we successfully captured CTCs from CRC patients using the unique biomaterial PMEA. Cultured tumor cells will provide important and timely information regarding the molecular basis of CTCs.

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  • Comparative study of PEG and PEGylated dendrimers in their eutectic mixtures with water analyzed using X-ray diffraction and infrared spectroscopy

    Kojima, C; Suzuki, Y; Ikemoto, Y; Tanaka, M; Matsumoto, A

    POLYMER JOURNAL   55 ( 1 )   63 - 73   2023年1月   ISSN:0032-3896 eISSN:1349-0540

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Polymer Journal  

    It has been reported that the hydration state of biocompatible polymers, such as poly(ethylene glycol) (PEG), affects their bioinertness. PEGylated dendrimers have been studied for use as drug carriers. In our previous study, the hydration behaviors of PEG and PEGylated dendrimers were analyzed using differential scanning calorimetry (DSC) to investigate the relationship between hydration and in vivo behaviors. In this study, the hydration behaviors of PEG and PEGylated dendrimer were analyzed using X-ray diffraction (XRD) and infrared (IR) spectroscopy. According to the XRD analysis, ice was formed and melted in the PEG/water mixture with a 20% water content below 0 °C during the heating process; however, PEG crystals were formed in the PEG/water mixture containing 70% water. The XRD and IR results of the PEGylated dendrimer/water mixture were similar to those of the PEG/water system containing 70% water. Our IR spectral studies indicated that the hydration state of the PEGylated dendrimer was different from that of PEG containing 20% water. These results suggested that a comprehensive study is important for the analysis of such eutectic mixtures of PEG compounds and water.

    DOI: 10.1038/s41428-022-00700-5

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  • https://www.soft-material.jp/achievement/articles 招待 査読

    2023年1月

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    担当区分:最終著者, 責任著者  

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  • Behavior of supramolecular cross-links formed by host-guest interactions in hydrogels responding to water contents

    Ueda C., Park J., Hirose K., Konishi S., Ikemoto Y., Osaki M., Yamaguchi H., Harada A., Tanaka M., Watanabe G., Takashima Y.

    Supramolecular Materials   1   100001 - 100001   2022年12月   ISSN:2667-2405

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Supramolecular Materials  

    Reversible or movable cross-links based on host-guest interactions in supramolecular materials create functions such as enhanced mechanical properties and stimulus responsiveness. A supramolecular complex on a polymer side chain achieves the described functions as a reversible cross-link. Generally, 1:1 complex is utilized as a cross-link for the host-guest interaction based-supramolecular materials, but herein, the 1:2 complex between γ-cyclodextrin (γCD) and methyl viologen terminated undecyl acrylate (VC11) was chosen to cross-link three polymeric chains. The obtained supramolecular hydrogels γCD-VC11 (x, y) (x and y represent the mol% of the γCD and VC11 units in feeding, respectively) was prepared by radical copolymerization with acrylamide as a mainchain monomer. Tensile test revealed that toughness (Gf) of γCD-VC11 (x, y) maximized at water content (Wc) ≈ 40 wt.%. The maxima of Gf depended on the amount of γCD and VC11 units. Through dynamic mechanical analysis, Arrhenius style plots between horizontal shift factors and temperature determined activation energies (Ea) of each γCD-VC11 (x, y) and MBAAm (0.5). Ea of MBAAm (0.5) monotonically decreased with the increasing Wc. On the other hand, slope of Ea of γCD-VC11 (x, y) changed at Wc ≈ 40 wt.%. Simultaneously considering results of the tensile tests and DMA, the reversible cross-links formed by γCD and VC11 in γCD-VC11 (x, y) function effectively at appropriate Wc.

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  • Honeycomb-like Structured Film, a Novel Therapeutic Device, Suppresses Tumor Growth in an In Vivo Ovarian Cancer Model

    Tsuyoshi Ohta, Masaru Tanaka, Seitaro Taki, Hiroyuki Nakagawa, Satoru Nagase

    Cancers   2022年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/cancers15010237

  • Honeycomb-like Structured Film, a Novel Therapeutic Device, Suppresses Tumor Growth in an In Vivo Ovarian Cancer Model

    Tsuyoshi Ohta, Masaru Tanaka, Seitaro Taki, Hiroyuki Nakagawa, Satoru Nagase

    Cancers   2022年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/cancers15010237

  • Alkyl chain length-dependent protein nonadsorption and adsorption properties of crystalline alkyl ?-celluloside assemblies

    Serizawa, T; Yamaguchi, S; Amitani, M; Ishii, S; Tsuyuki, H; Tanaka, Y; Sawada, T; Kawamura, I; Watanabe, G; Tanaka, M

    COLLOIDS AND SURFACES B-BIOINTERFACES   220   112898   2022年12月   ISSN:0927-7765 eISSN:1873-4367

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Colloids and Surfaces B: Biointerfaces  

    Cellulose-based crystalline assemblies artificially constructed in a bottom-up manner are attracting increasing attention as chemically stable and functionally designable nano- to macroscale materials. However, basic knowledge of how such crystalline assemblies interact with biomolecules and how to control them via molecular design is still limited. In this study, we investigated the protein adsorption properties of crystalline lamella assemblies composed of alkyl β-cellulosides (namely, ethyl, n-butyl, and n-hexyl β-cellulosides) or plain cellulose, which all have an antiparallel molecular arrangement. It was found that the adsorption of proteins was observed only for the n-hexyl β-celluloside assembly, while it was hardly observed for other assemblies. The n-hexyl groups appeared to be ordinarily embedded in the assembly surface in an aqueous phase, while, when in contact with proteins, n-hexyl groups appeared to be tethered to promote protein adsorption. All-atom molecular dynamics simulations supported the contradictory protein adsorption properties. The basic knowledge obtained herein is highly valuable for controlling the interactions of cellulose-based synthetic assemblies with proteins for designing new biological applications.

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  • Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet‐Resistant Bioelectrode Applications

    Jing‐Ju Huang, Chia‐Hsuan Lin, Yukiko Tanaka, Aki Yamamoto, Shyh‐Chyang Luo, Masaru Tanaka

    ADVANCED MATERIALS INTERFACES   9 ( 33 )   2022年11月   ISSN:2196-7350

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Advanced Materials Interfaces  

    Poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have demonstrated potential in the development of bioelectrodes because of their superior conductivity. However, developing reliable implanted bioelectrodes requires improvements in biocompatibility and the prevention of nonspecific adhesion. In this study, a six ethylene glycol (EG)-functionalized EDOTs with three different EG lengths (tri-EG, tetra-EG, and hexa-EG) and two types of end groups, hydroxyl (−OH) and methoxy (−OCH3) is synthesized and systematically investigated. By coating them on gold electrodes using electropolymerization, the surface and electrochemical properties of these functionalized PEDOT-coated electrodes are investigated. Although PEDOT with −OH groups on the surface is more hydrophilic, those with −OCH3 groups on the surface exhibit higher electrochemical activity and lower impedance. The increase in EG units and −OCH3 groups on the surface effectively reduces the adhesion between the PEDOT and atomic force microscopy tips. PEDOT with longer EG lengths and −OCH3 groups exhibits relatively few adhered platelets, and the results of the analysis of hydrated states through differential scanning calorimetry are consistent with those of the platelet adhesion test. This study suggests that a tetra(EG)-functionalized PEDOT with −OCH3 groups on the surface is a promising coating for implanted bioelectrode applications.

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  • Enrichment of Cancer Cells Based on Antibody-Free Selective Cell Adhesion

    Kobayashi, S; Sugasaki, A; Yamamoto, Y; Shigenoi, Y; Udaka, A; Yamamoto, A; Tanaka, M

    ACS BIOMATERIALS SCIENCE & ENGINEERING   8 ( 10 )   4547 - 4556   2022年10月   ISSN:2373-9878 eISSN:2373-9878

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Biomaterials Science and Engineering  

    Blood-compatible and cell-adhering polymer materials are extremely useful for regenerative medicine and disease diagnosis. (Meth)acryl polymers with high hydrophilicity have been widely used in industries, and attempts to apply these polymers in the medical field are frequently reported. We focused on crosslinked polymer films prepared using bifunctional monomers, which are widely used as coating materials, and attempted to alter the cell adhesion behavior while maintaining blood compatibility by changing the chemical structure of the crosslinker. Four bifunctional monomers were studied, three of which were found to be blood-compatible polymers and to suppress platelet adhesion. The adhesion behavior of cancer cells to polymer films varied; moreover, the cancer model cells MCF-7 [EpCAM(+)] and MDA-MB-231 [EpCAM (-)], with different expression levels of epithelial cell adhesion molecule (EpCAM), showed distinct adhesion behavior for each material. We suggest that a combination of these materials has the potential to selectively capture and enrich highly metastatic cancer cells.

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  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Park J., Ueda T., Kawai Y., Araki K., Kido M., Kure B., Takenaka N., Takashima Y., Tanaka M.

    RSC Advances   12 ( 43 )   27912 - 27917   2022年9月

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    出版者・発行元:RSC Advances  

    The demand for artificial blood vessels to treat vascular disease will continue to increase in the future. To expand the application of blood-compatible poly(2-methoxyethyl acrylate) (pMEA) to artificial blood vessels, control of the mechanical properties of pMEA is established using supramolecular cross-links based on inclusion complexation of acetylated cyclodextrin. The mechanical properties, such as Young's modulus and toughness, of these pMEA-based elastomers change with the amount of cross-links, maintaining tissue-like behavior (J-shaped stress-strain curve). Regardless of the cross-links, the pMEA-based elastomers exhibit low platelet adhesion properties (approximately 3% platelet adherence) compared with those of poly(ethylene terephthalate), which is one of the commercialized materials for artificial blood vessels. Contact angle measurements imply a shift of supramolecular cross-links in response to the surrounding environment. When immersed in water, hydrophobic supramolecular cross-links are buried within the interior of the materials, thereby exposing pMEA chains to the aqueous environment; this is why supramolecular cross-links do not affect the platelet adhesion properties. In addition, the elastomers exhibit stable adhesion to human umbilical vein endothelial cells. This report shows the potential of combining supramolecular cross-links and pMEA.

    DOI: 10.1039/d2ra04885j

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  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Park, J; Ueda, T; Kawai, Y; Araki, K; Kido, M; Kure, B; Takenaka, N; Takashima, Y; Tanaka, M

    RSC ADVANCES   12 ( 43 )   27912 - 27917   2022年9月   eISSN:2046-2069

  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate.

    Park J, Ueda T, Kawai Y, Araki K, Kido M, Kure B, Takenaka N, Takashima Y, Tanaka M

    RSC advances   12 ( 43 )   27912 - 27917   2022年9月

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    記述言語:英語  

    DOI: 10.1039/d2ra04885j

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  • Organic carboxylate salt-enabled alternative synthetic routes for bio-functional cyclic carbonates and aliphatic polycarbonates

    Watanabe, Y; Takaoka, S; Haga, Y; Kishi, K; Hakozaki, S; Narumi, A; Kato, T; Tanaka, M; Fukushima, K

    POLYMER CHEMISTRY   13 ( 36 )   5193 - 5199   2022年9月   ISSN:1759-9954 eISSN:1759-9962

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Polymer Chemistry  

    Simple and efficient synthetic routes for functionalized cyclic carbonates are indispensable for the practical application of side-chain bio-functionalized aliphatic polycarbonates as biodegradable functional biomaterials. In this study, a six-membered cyclic carbonate with a triethylammonium carboxylate has been prepared in one step from 2,2-bis(methylol)propionic acid (bis-MPA). We have demonstrated the suitability of the organic carboxylate salt of the bis-MPA cyclic carbonate for esterification with alkyl bromides via the SN2 mechanism, leading to the formation of functionalized cyclic carbonate monomers. The esterification of the organic carboxylate salt proceeds efficiently when alkyl bromides with α-carbonyl, allyl, and benzyl groups are used. This approach enables a two-step synthesis of functionalized cyclic carbonates from bis-MPA. The organocatalyzed ring-opening polymerization of the resultant functionalized cyclic carbonates is effectively controlled, indicating that the synthetic process involving the organic carboxylate salt does not influence their polymerizability. The ether-functionalized aliphatic polycarbonates obtained from the organic carboxylate salt exhibit good antiplatelet properties, comparable to those of a previously developed blood-compatible aliphatic polycarbonate. The synthetic pathways exploiting organic carboxylate salts enable alternative shortcuts to functionalized cyclic carbonates from bis-MPA.

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  • ソフトバイオマテリアル・バイオ界面における水の状態と役割

    田中 賢

    化学と教育   70 ( 7 )   348 - 351   2022年7月   ISSN:03862151 eISSN:24241830

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    記述言語:日本語   出版者・発行元:公益社団法人 日本化学会  

    <p>医療製品の開発には,生体に接触する環境で安全に機能する生体親和性に優れたソフトバイオマテリアルが必須である。医療製品は,使用する前の滅菌済みの乾燥状態から,使用時にはウエットな状態に変化する。本講座では,製品使用環境で存在する水の視点を考慮し,材料と生体の接触点であるバイオ界面の設計における課題と進展について概説する。生体親和性に強く影響する材料—細胞間相互作用には,多くの因子が関与している。我々は,生体親和性合成材料と生体分子に形成される水の状態を調べ,特定の構造と運動性を有する中間水が共通点であることを明らかにした。中間水のバイオ界面における役割について考察する。</p>

    DOI: 10.20665/kakyoshi.70.7_348

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  • Roles of interfacial water states on advanced biomedical material design

    Nishida, K; Anada, T; Tanaka, M

    ADVANCED DRUG DELIVERY REVIEWS   186   114310   2022年7月   ISSN:0169-409X eISSN:1872-8294

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    記述言語:その他   出版者・発行元:Advanced Drug Delivery Reviews  

    When biomedical materials come into contact with body fluids, the first reaction that occurs on the material surface is hydration; proteins are then adsorbed and denatured on the hydrated material surface. The amount and degree of denaturation of adsorbed proteins affect subsequent cell behavior, including cell adhesion, migration, proliferation, and differentiation. Biomolecules are important for understanding the interactions and biological reactions of biomedical materials to elucidate the role of hydration in biomedical materials and their interaction partners. Analysis of the water states of hydrated materials is complicated and remains controversial; however, knowledge about interfacial water is useful for the design and development of advanced biomaterials. Herein, we summarize recent findings on the hydration of synthetic polymers, supramolecular materials, inorganic materials, proteins, and lipid membranes. Furthermore, we present recent advances in our understanding of the classification of interfacial water and advanced polymer biomaterials, based on the intermediate water concept.

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  • Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel 査読

    Haque, MA; Murakami, D; Tanaka, M

    SURFACES   5 ( 3 )   365 - 382   2022年7月   eISSN:2571-9637

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Surfaces  

    Poly(2-methoxyethyl acrylate) (PMEA) is a US FDA-approved biocompatible polymer, although there is insufficient work on human umbilical vein endothelial cells (HUVECs) and platelet interaction analysis on PMEA-analogous polymers. In this study, we extensively investigated HUVEC–polymer and platelet–polymer interaction behavior by measuring the adhesion strength using single-cell force spectroscopy. Furthermore, the hydration layer of the polymer interface was observed using frequency-modulation atomic force microscopy. We found that endothelial cells can attach and spread on the PMEA surface with strong adhesion strength compared to other analogous polymers. We found that the hydration layers on the PMEA-analogous polymers were closely related to their weak platelet adhesion behavior. Based on our results, it can be concluded that PMEA is a promising candidate for the construction of artificial small-diameter blood vessels owing to the presence of IW and a hydration layer on the interface.

    DOI: 10.3390/surfaces5030027

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  • Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode

    Mabrouk, M; Beherei, HH; Tanaka, Y; Tanaka, M

    BIOMATERIALS ADVANCES   138   212965   2022年7月   ISSN:2772-9508 eISSN:2772-9508

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomaterials Advances  

    The hydration state of bioactive glass materials and its relationship with their biocompatibility have been receiving attention. In this research, silver-containing bioactive glasses (BGAgs) (Ag contents of 0.25, 0.5, and 1.0% in the glass system) were developed using the sol-gel method. Their physicochemical properties, size, morphology, and surface area were characterized by conducting X-rays diffraction (XRD), Fourier transform infrared (FTIR), Transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) surface area analyses. The surface charges of the developed BGAgs were evaluated using the Nano Zetasizer. Moreover, the antibacterial activities and intermediate water (IW) contents of hydrated BGAgs were determined. Finally, BGAgs disks were tested against osteosarcoma (MG63) cell line to evaluate their death modes. The physicochemical characteristics of the BGAgs revealed no modifications after Ag doping. In comparison, relative changes were recorded in the particle size (20–33 to 16–29 nm), surface area (4.3 to 3.7 m2/g), and particle charge (−24 to −14.6 mV). Doping the current glass system with silver produced impressive amounts of IW, consistent with recorded proliferation rates of the cells when treated with BGAgs. The determined hydration states correlated with other findings in this research might be helpful in predicting and assessing the biological behaviors of BGAgs.

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  • Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions 国際誌

    Yuka Ikemoto, Yoshihisa Harada, Masaru Tanaka, Shin-nosuke Nishimura, Daiki Murakami, Naoya Kurahashi, Taro Moriwaki, Kosuke Yamazoe, Hitoshi Washizu, Yoshiki Ishii, Hajime Torii

    The Journal of Physical Chemistry B   2022年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.jpcb.2c01702

  • Characterization of Hydration Water Bound to Choline Phosphate- Containing Polymers

    Shiomoto, S; Inoue, K; Higuchi, H; Nishimura, SN; Takaba, H; Tanaka, M; Kobayashi, M

    BIOMACROMOLECULES   23 ( 7 )   2999 - 3008   2022年6月   ISSN:1525-7797 eISSN:1526-4602

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomacromolecules  

    Zwitterionic methacrylate polymers with either choline phosphate (CP) (poly(MCP)) or phosphorylcholine (PC) (poly(MPC)) side groups were analyzed to characterize the bound hydration water molecules as nonfreezing water (NFW), intermediate water (IW), or free water (FW). This characterization was carried out by differential scanning calorimetry (DSC) of polymer/water systems, and the enthalpy changes of cold crystallization and melting were determined. The electron pair orientation of CP is opposite to that of PC, and the former binds the alkyl terminal groups at the phosphate esters. The numbers of NFW and IW molecules per monomer unit of poly(MCP) with an isopropyl terminal group were estimated to be 10.7 and 11.3 mol/mol, respectively, which were slightly greater than those of the poly(MCP) bearing an ethyl terminal group. More NFW and IW molecules hydrated the phosphobetaine polyzwitterions, poly(MCP) and poly(MPC), compared with carboxybetaine and sulfobetaine polymers. Moreover, the hydration states of polyelectrolytes were compared with the zwitterionic polymers. Finally, we discuss the relationship between the amount of hydration water and bio-inert properties.

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  • Poly(2-Methoxyethyl Acrylate) (PMEA)-Coated Anti-Platelet Adhesive Surfaces to Mimic Native Blood Vessels through HUVECs Attachment, Migration, and Monolayer Formation 査読

    Haque, MA; Murakami, D; Anada, T; Tanaka, M

    COATINGS   12 ( 6 )   869   2022年6月   eISSN:2079-6412

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Coatings  

    Confluent monolayers of human umbilical vein endothelial cells (HUVECs) on a poly(2-methoxyethyl acrylate) (PMEA) antithrombogenic surface play a major role in mimicking the inner surface of native blood vessels. In this study, we extensively investigated the behavior of cell–polymer and cell–cell interactions by measuring adhesion strength using single-cell force spectroscopy. In addition, the attachment and migration of HUVECs on PMEA-analogous substrates were detected, and the migration rate was estimated. Moreover, the bilateral migration of HUVECs between two adjacent surfaces was observed. Furthermore, the outer surface of HUVEC was exam-ined using frequency-modulation atomic force microscopy (FM-AFM). Hydration was found to be an indication of a healthy glycocalyx layer. The results were compared with the hydration states of individual PMEA-analogous polymers to understand the adhesion mechanism between the cells and substrates in the interface region. HUVECs could attach and spread on the PMEA surface with stronger adhesion strength than self-adhesion strength, and migration occurred over the surface of analogue polymers. We confirmed that platelets could not adhere to HUVEC monolayers cultured on the PMEA surface. FM-AFM images revealed a hydration layer on the HUVEC surfaces, indicating the presence of components of the glycocalyx layer in the presence of intermediate water. Our findings show that PMEA can mimic original blood vessels through an antithrombogenic HUVEC monolayer and is thus suitable for the construction of artificial small-diameter blood vessels.

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  • Biocompatible poly(<i>N</i>-(ω-acryloyloxy-<i>n</i>-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(<i>N</i>-isopropylacrylamide)

    Nishimura, SN; Nishida, K; Ueda, T; Shiomoto, S; Tanaka, M

    POLYMER CHEMISTRY   13 ( 17 )   2519 - 2530   2022年5月   ISSN:1759-9954 eISSN:1759-9962

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Polymer Chemistry  

    Poly(N-isopropylacrylamide) (PNIPAM) is one of the most commonly used thermo-responsive polymers. PNIPAM has a lower critical solution temperature (LCST) of approximately 32 °C, which is close to the temperature of the human body. Thus, it has long been used in biological applications. Although PNIPAM is commonly thought to be biocompatible and safe, it often induces blood clots, because the polymer contains a hydrogen-bond donor. Therefore, thermo-responsive materials with aprotic polar functional groups are needed as an alternative to PNIPAM. In this study, we focused on the pyrrolidone ring, which is an aprotic polar functional group that acts as a proton acceptor and has a high hydration ability, and prepared acrylate polymers containing this ring at the end of a side chain. These polymers, (poly(N-(ω-acryloyloxy-n-alkyl)-2-pyrrolidone)s (PNARPs) (R = methyl (Me), ethyl (Et), propyl (Pr), butyl (Bu), pentyl (Pn), and hexyl (Hx)), were readily synthesized by conventional free-radical polymerization. When the temperature was above the LCST, some of the PNARPs underwent liquid-liquid phase separation (LLPS) and formed coacervates in water. Simple copolymerization of the monomers, particularly the combination of NAEtP and NAHxP, resulted in copolymers with LCSTs that were able to be widely and precisely controlled between 0 °C and 100 °C in water and phosphate-buffered saline (−) ((PBS (−)). These(co)polymers also exhibited good blood compatibility and cell affinity. Interestingly, when the hydrophobic/hydrophilic balance of the (co)polymers was changed, macrophages could be activated without causing cytotoxicity. These unique (co)polymers have attractive characteristics that make them suitable replacements for PNIPAM, as well as promising functional materials with applications in many fields.

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  • Surfactant-free suspension polymerization of hydrophilic monomers with an oil-in-water system for the preparation of microparticles toward the selective isolation of tumor cells 査読

    Nishimura, SN; Nishida, K; Shiomoto, S; Tanaka, M

    MATERIALS ADVANCES   3 ( 12 )   5043 - 5054   2022年5月   eISSN:2633-5409

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Materials Advances  

    Polymer microparticles, composed of water-soluble hydrophilic monomers, are synthesized via surfactant-free suspension polymerization with an oil-in-water system. Microparticles formed from PMEA have potential as a platform to capture tumor cells.

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  • Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins 国際誌

    Hishida, M; Anjum, R; Anada, T; Murakami, D; Tanaka, M

    JOURNAL OF PHYSICAL CHEMISTRY B   126 ( 13 )   2466 - 2475   2022年4月   ISSN:1520-6106 eISSN:1520-5207

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Physical Chemistry B  

    There is a long, ongoing debate on how small molecules (osmolytes) affect the stability of proteins. The present study found that change in collective rotational dynamics of water in osmolyte solutions likely has a dominant effect on protein denaturation. According to THz spectroscopy analysis, osmolytes that stabilize proteins are accompanied by bound hydration water with slow dynamics, while the collective rotational dynamics of water is accelerated in the case of denaturant osmolytes. Among 15 osmolytes studied here, there is a good correlation between the change in mobility in terms of water rotational dynamics and the denaturation temperature of ribonuclease A. The changes in water dynamics due to osmolytes can be regarded as a pseudo-temperature-change, which agrees well with the change in protein denaturation temperature. These results indicate that the molecular dynamics of water around the protein is a key factor for protein denaturation.

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  • Nanoscopic analyses of cell-adhesive protein adsorption on poly(2-methoxyethyl acrylate) surfaces 査読

    Nishida, K; Baba, K; Murakami, D; Tanaka, M

    BIOMATERIALS SCIENCE   10 ( 11 )   2953 - 2963   2022年4月   ISSN:2047-4830 eISSN:2047-4849

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomaterials Science  

    Regulation of protein adsorption on the surface of biomaterials is important for modulating cell adhesion. Two important proteins in this regard are fibrinogen and fibronectin. Poly(2-methoxyethyl acrylate) (PMEA) and its derivatives have been developed as promising coating materials for biomaterial surfaces. Previous studies have highlighted that PMEA-coated substrates suppress thrombogenicity but promote cell adhesiveness. However, it was unclear what was responsible for these differences in adhesion. In this study, we focused on the correlation between protein adsorption and the nanometer-scale structures on the surfaces of the PMEA substrates. An atomic force microscope using protein- or antibody-conjugated cantilevers was used to perform nanoscopic analyses of the adsorption forces and conformational changes in fibrinogen and fibronectin adsorbed on the nanometer-scale PMEA structures. The adsorption force of fibronectin in the polymer-poor region was higher than that of fibrinogen, whereas the polymer-rich region showed a negligible difference in adsorption force between the two proteins. Interestingly, a greater conformational change in the adsorbed fibronectin was induced in the polymer-poor region than that in fibronectin in the polymer-rich region or fibrinogen in either regions, resulting in the induction of cell adhesion. Nanoscopic analyses of protein adsorption on biomaterial surfaces provide promising insights into the design of novel biomaterials that control protein adsorption and cell adhesion.

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  • Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer

    Nishida, K; Nishimura, SN; Tanaka, M

    BIOMACROMOLECULES   23 ( 4 )   1569 - 1580   2022年4月   ISSN:1525-7797 eISSN:1526-4602

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomacromolecules  

    Selective targeting of specific cells without the use of biological ligands has not been achieved. In the present study, we revealed that the coacervate droplets formed from poly(2-methoxyethyl acrylate) (PMEA) and its derivatives selectively accumulated to tumor cells. PMEA derivatives, which are insoluble acrylate polymers, induced coacervation in water to form polymer-dense droplets via hydrophobic interaction. Interestingly, the accumulation of coacervate droplets to tumor cells was involved in the bound water content of PMEA derivatives. Coacervate droplets with a high bound water content accumulated and internalized up to 36.6-fold higher in HeLa cervical tumor cells than in normal human fibroblasts (NHDF). Moreover, the interactions between coacervate droplets and plasma membrane components such as CD44 played a key role in this accumulation process. Therefore, coacervate droplets formed from PMEA derivatives have great clinical potential in tumor cell detection, development of alternative tumor-targeting ligands, and optimization of drug delivery carriers.

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  • Experimental Evidence of Slow Mode Water in the Vicinity of Poly(ethylene oxide) at Physiological Temperature 国際誌

    Tominaga, T; Hishida, M; Murakami, D; Fujii, Y; Tanaka, M; Seto, H

    JOURNAL OF PHYSICAL CHEMISTRY B   126 ( 8 )   1758 - 1767   2022年3月   ISSN:1520-6106 eISSN:1520-5207

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Physical Chemistry B  

    In some synthetic polymers used for medical applications, hydration water in the vicinity of the polymer chains is known to play an important role in biocompatibility and is referred to as intermediate water. The crystallization of water below 0 °C observed during thermal analysis has been considered as evidence of the presence of intermediate water. However, the origin and physicochemical properties of intermediate water have not yet been elucidated. In this study, as a typical biocompatible polymer, poly(ethylene oxide) and its hydration water were investigated with the use of terahertz time-domain spectroscopy and quasi-elastic neutron scattering. The obtained results prove the existence of a significant amount of mobile water that interacts with the polymer chains even when the water content is low at physiological temperatures.

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  • Modulation of Biological Responses of Tumor Cells Adhered to Poly(2-methoxyethyl acrylate) with Increasing Cell Viability under Serum-Free Conditions

    Nishida, K; Sekida, S; Anada, T; Tanaka, M

    ACS BIOMATERIALS SCIENCE & ENGINEERING   8 ( 2 )   672 - 681   2022年2月   ISSN:2373-9878 eISSN:2373-9878

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Biomaterials Science and Engineering  

    Circulating tumor cells in body fluids are important biomarkers in cancer diagnosis. The culture of tumor cells isolated from body fluids can provide intrinsic information about tumors and can be used to screen for the best anticancer drugs. However, the culture of primary tumor cells has been hindered by their low viability and difficulties in recapitulating the phenotype of primary tumors in in vitro culture. The culture of tumor cells under serum-free conditions is one of the methodologies to maintain the phenotype and genotype of primary tumors. Poly(2-methoxyethyl acrylate) (PMEA)-coated substrates have been investigated to prolong the proliferation of tumor cells under serum-free conditions. In this study, we investigated the detailed behavior and the mechanism of the increase in tumor cell viability after adherence to PMEA substrates. The blebbing formation of tumor cells on PMEA was attributed not to apoptosis but to the low adhesion strength of cells on PMEA. Moreover, blebbing tumor cells showed amoeboid movement and formed clusters with other cells via N-cadherin, leading to an increase in tumor cell viability. Furthermore, the behaviors of tumor cells adhered to PMEA under serum-free conditions were involved in the activation of the PI3K and Rho-associated protein kinase pathways. Thus, we propose that PMEA would be suitable for the development of devices to cultivate primary tumor cells under serum-free conditions for the label-free diagnosis of cancer.

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  • Observing the repulsion layers on blood-compatible polymer-grafted interfaces by frequency modulation atomic force microscopy

    Murakami, D; Nishimura, SN; Tanaka, Y; Tanaka, M

    BIOMATERIALS ADVANCES   133   112596 - 112596   2022年2月   ISSN:2772-9508 eISSN:2772-9508

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomaterials Advances  

    Blood-compatible materials that do not promote reactions in contact with human blood are required to support emerging medical technologies. The interfaces of poly(2-methoxyethyl acrylate) (PMEA), a blood-compatible polymer, and its analogues were investigated by frequency modulation atomic force microscopy (FM-AFM). The grafted polymers exhibited phase separation into polymer-rich and water-rich domains. Thin repulsive layers of hydrated polymer chains were observed in the water-rich domains of the blood-compatible polymers; on the other hand, such layers were not observed for the non-blood-compatible polymers. We report for the first time that FM-AFM enables characteristic repulsive layers composed of hydrated polymer chains in water-rich domains to be observed, which is a significant design factor for blood-compatible polymers.

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  • A β-hairpin peptide with pH-controlled affinity for tumor cells

    Nishimura, SN; Nishida, K; Tanaka, M

    CHEMICAL COMMUNICATIONS   58 ( 4 )   505 - 508   2022年1月   ISSN:1359-7345 eISSN:1364-548X

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Chemical Communications  

    Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.

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  • Fluorine-containing bio-inert polymers: Roles of intermediate water

    Koguchi, R; Jankova, K; Tanaka, M

    ACTA BIOMATERIALIA   138   34 - 56   2022年1月   ISSN:1742-7061 eISSN:1878-7568

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Acta Biomaterialia  

    Fluorine-containing polymers are used not only in industrial processes but also in medical applications, because they exhibit excellent heat, weather, and chemical resistance. As these polymers are not easily degraded in our body, it is difficult to use them in applications that require antithrombotic properties, such as artificial blood vessels. The material used for medical applications should not only be stable in vivo, but it should also be inert to biomolecules such as proteins or cells. In this review, this property is defined as “bio-inert,” and previous studies in this field are summarized. Bio-inert materials are less recognized as foreign substances by proteins or cells in the living body, and they must be covered at interfaces designed with the concept of intermediate water (IW). On the basis of this concept, we present here the current understanding of bio-inertness and unusual blood compatibility found in fluoropolymers used in biomedical applications. IW is the water that interacts with materials with moderate strength and has been quantified by a variety of analytical methods and simulations. For example, by using differential scanning calorimetry (DSC) measurements, IW was defined as water frozen at around -40°C. To consider the role of the IW, quantification methods of the hydration state of polymers are also summarized. These investigations have been conducted independently because of the conflict between hydrophobic fluorine and bio-inert properties that require hydrophilicity. In recent years, not many materials have been developed that incorporate the good points of both aspects, and their properties have seldom been linked to the hydration state. This has been critically performed now. Furthermore, fluorine-containing polymers in medical use are reviewed. Finally, this review also describes the molecular design of the recently reported fluorine-containing bio-inert polymers for controlling their hydration state. Statement of significance: A material covered with a hydration layer known as intermediate water that interacts moderately with other objects is difficult to be recognized as a foreign substance and exhibits bio-inert properties. Fluoropolymers show high durability, but conflict with bio-inert characteristics requiring hydrophilicity as these research studies have been conducted independently. On the other hand, materials that combine the advantages of both hydrophobic and hydrophilic features have been developed recently. Here, we summarize the molecular architecture and analysis methods that control intermediate water and provide a guideline for designing novel fluorine-containing bio-inert materials.

    DOI: 10.1016/j.actbio.2021.10.027

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  • Anisotropic, Degradable Polymer Assemblies Driven by a Rigid Hydrogen-Bonding Motif That Induce Shape-Specific Cell Responses

    Fukushima, K; Matsuzaki, K; Oji, M; Higuchi, Y; Watanabe, G; Suzuki, Y; Kikuchi, M; Fujimura, N; Shimokawa, N; Ito, H; Kato, T; Kawaguchi, S; Tanaka, M

    MACROMOLECULES   55 ( 1 )   15 - 25   2022年1月   ISSN:0024-9297 eISSN:1520-5835

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Macromolecules  

    Poly(ethylene glycol)-conjugated amphiphilic block copolymers, which contain degradable hydrophobic blocks connected by a rigid hydrogen-bonding motif (RHM), are developed to yield anisotropic nanoassemblies in a manner independent of the crystalline nature of the hydrophobic block. The all-atom and coarse-grained molecular dynamics simulations suggest that the anisotropic alignment of the block copolymers can be attributed to the π-πinteractions of the RHM and the crystallizable hydrophobic blocks help maintain the aligned structure. Light scattering analysis of the polymer assemblies demonstrates the formation of nonspherical assemblies by the RHM-containing block copolymers with an amorphous hydrophobic block; this indicates the strong contribution of the RHM to the directed assembly of the block copolymers, unlike crystallization-driven self-assembly. Enhanced cell proliferation is observed in cell cultures containing normal human fibroblasts in the presence of the anisotropic polymer assemblies with aspect ratios greater than 12 or lengths greater than 310 nm.

    DOI: 10.1021/acs.macromol.1c01894

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  • Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation

    Murakami, D; Yamazoe, K; Nishimura, S; Kurahashi, N; Ueda, T; Miyawaki, J; Ikemoto, Y; Tanaka, M; Harada, Y

    LANGMUIR   38 ( 3 )   1090 - 1098   2022年1月   ISSN:0743-7463 eISSN:1520-5827

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Langmuir  

    Interactions involving intermediate water are crucial for the design of novel blood-compatible materials. Herein, we use a combination of atomic force microscopy, quartz crystal microbalance measurements, and soft X-ray emission spectroscopy to investigate the local hydrogen-bonded configuration of water on blood-compatible poly(2-methoxyethyl acrylate) and non-blood-compatible poly(n-butyl acrylate) grafted on a gold substrate. We find that the initially incorporated water induces polymer-dependent phase separation, facilitating further water uptake. For the blood-compatible polymer, tetrahedrally coordinated water coexists with water adsorbed on C═O groups in low-density regions of the grafted polymer surface, providing a scaffold for the formation of intermediate water. The amount of intermediate water is determined by the type of functional groups, local polymer configuration, and polymer morphology. Thus, blood compatibility is governed by the complex water/polymer interactions.

    DOI: 10.1021/acs.langmuir.1c02672

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  • Water modulates the lamellar structure and interlayer correlation of poly(perfluorooctyl acrylate) films: a specular and off-specular neutron scattering study

    Yamamoto, A; Higaki, Y; Thoma, J; Kimmle, E; Ishige, R; Demé, B; Takahara, A; Tanaka, M

    POLYMER JOURNAL   54 ( 1 )   57 - 65   2022年1月   ISSN:0032-3896 eISSN:1349-0540

  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Park, J., Ueda, T., Kawai, Y., Araki, K., Kido, M., Kure, B., Takenaka, N., Takashima, Y., Tanaka, M.

    RSC Advances   12 ( 43 )   2022年   ISSN:2046-2069

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/d2ra04885j

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  • Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular substrate

    Junsu Park, Tomoya Ueda, Yusaku Kawai, Kumiko Araki, Makiko Kido, Bunsho Kure, Naomi Takenaka, Yoshinori Takashima, Masaru Tanaka

    RSC Advances   2022年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/D2RA04885J

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  • Effect of pendant groups on the blood compatibility and hydration states of poly(2-oxazoline)s

    Liu, S., Kobayashi, S., Nishimura, S.-N., Ueda, T., Tanaka, M.

    Journal of Polymer Science   59 ( 21 )   2559 - 2570   2021年11月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/pol.20210410

  • Effect of amount of hydrated water and mobility of hydrated poly(2‐methoxyethyl acrylate) on denaturation of adsorbed fibrinogen

    59 ( 22 )   2763 - 2770   2021年11月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/pol.20210496

  • Conformable microneedle pH sensors via the integration of two different siloxane polymers for mapping peripheral artery disease

    Wonryung Lee, Seung-hwan Jeong, Young-Woo Lim, Hyunhwan Lee, Joohyuk Kang, Hyunjae Lee, Injun Lee, Hyung-Seop Han, Shingo Kobayashi, Masaru Tanaka, Byeong-Soo Bae

    Science Advances   7 ( 48 )   2021年11月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1126/sciadv.abi6290

  • Protein- and Cell-Resistance of Zwitterionic Peptide-Based Self-Assembled Monolayers: Anti-Biofouling Tests and Surface Force Analysis

    Ryongsok Chang, Evan Angelo Quimada Mondarte, Debabrata Palai, Taito Sekine, Aki Kashiwazaki, Daiki Murakami, Masaru Tanaka, Tomohiro Hayashi

    Frontiers in Chemistry   9   2021年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3389/fchem.2021.748017

  • Local Dynamics of the Hydration Water and Poly(Methyl Methacrylate) Chains in PMMA Networks 査読 国際誌

    Yoshihisa Fujii, Taiki Tominaga, Daiki Murakami, Masaru Tanaka, Hideki Seto

    Frontiers in Chemistry   9   728738 - 728738   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3389/fchem.2021.728738

  • Mechanical Properties with Respect to Water Content of Host–Guest Hydrogels

    54 ( 17 )   8067 - 8076   2021年9月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.1c00970

  • Protein Stabilization Effect of Zwitterionic Osmolyte-bearing Polymer

    Rubaiya Anjum, Shin-nosuke Nishimura, Shingo Kobayashi, Kei Nishida, Takahisa Anada, Masaru Tanaka

    Chemistry Letters   50 ( 9 )   1699 - 1702   2021年9月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.210335

  • Effect of amount of hydrated water and mobility of hydrated poly(2-methoxyethyl acrylate) on denaturation of adsorbed fibrinogen

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    JOURNAL OF POLYMER SCIENCE   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/pol.20210496

  • Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship between Hydration States and Surface Morphology

    Moe Yamazaki, Yosuke Sugimoto, Daiki Murakami, Masaru Tanaka, Tooru Ooya

    Langmuir   37 ( 28 )   8534 - 8543   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.1c01003

  • Investigating the intermediate water feature of hydrated titanium containing bioactive glass

    Mabrouk, M., Beherei, H.H., Tanaka, Y., Tanaka, M.

    International Journal of Molecular Sciences   22 ( 15 )   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms22158038

  • Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass

    Mostafa Mabrouk, Hanan H. Beherei, Yukiko Tanaka, Masaru Tanaka

    International Journal of Molecular Sciences   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms22158038

  • First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water

    Kanamaru, T., Araki, M., Takahashi, R., Fujii, S., Shikata, T., Murakami, D., Tanaka, M., Sakurai, K.

    Journal of Physical Chemistry B   125 ( 26 )   7251 - 7261   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.jpcb.1c01864

  • Effect of Branching Degree of Dendritic Polyglycerols on Plasma Protein Adsorption: Relationship between Hydration States and Surface Morphology

    Moe Yamazaki, Yosuke Sugimoto, Daiki Murakami, Masaru Tanaka, Tooru Ooya

    Langmuir   37 ( 28 )   8534 - 8543   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.1c01003

  • First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water

    Takuma Kanamaru, Masataka Araki, Rintaro Takahashi, Shota Fujii, Toshiyuki Shikata, Daiki Murakami, Masaru Tanaka, Kazuo Sakurai

    The Journal of Physical Chemistry B   125 ( 26 )   7251 - 7261   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.jpcb.1c01864

  • Effect of pendant groups on the blood compatibility and hydration states of poly(2‐oxazoline)s

    Shichen Liu, Shingo Kobayashi, Shin‐nosuke Nishimura, Tomoya Ueda, Masaru Tanaka

    59 ( 21 )   2559 - 2570   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/pol.20210410

  • Effect of bound water content on cell adhesion strength to water-insoluble polymers

    Kei Nishida, Takahisa Anada, Shingo Kobayashi, Tomoya Ueda, Masaru Tanaka

    Acta Biomaterialia   134   313 - 324   2021年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.actbio.2021.07.058

  • The first observation of the hydration layer around polymer chain by scattering and its relationship to thromboresistance; dilute solution properties of PMEA in THF/water 査読 国際誌

    T. Kanamaru, M. Araki, R. Takahashi, S. Fujii, T. Shikata, D. Murakami, M. Tanaka, K. Sakurai

    The Journal of Physical Chemistry B   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Poly(tertiary amide acrylate) Copolymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States

    Shichen Liu, Shingo Kobayashi, Toshiki Sonoda, Masaru Tanaka

    Biomacromolecules   22 ( 6 )   2718 - 2728   2021年6月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.1c00411

  • Effects of Side-Chain Spacing and Length on Hydration States of Poly(2-methoxyethyl acrylate) Analogues: A Molecular Dynamics Study

    An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science & Engineering   7 ( 6 )   2383 - 2391   2021年6月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.1c00388

  • In vitro and In vivo Blood Compatibility of Concentrated Polymer Brushes 招待 査読 国際誌

    C. Yoshikawa, S. Hattori, C-F. Huang, H. Kobayashi, M. Tanaka

    Journal of Materials Chemistry B   2021年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Poly(tertiary amide acrylate) (Co)polymers Inspired by Poly(2-oxazoline)s: Their Blood Compatibility and Hydration States 査読 国際誌

    S. Liu, S. Kobayashi, T. Sonoda, M. Tanaka

    Biomacromolecules   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.1c0041

  • Attachment and Growth of Fibroblast Cells on Poly(2-methoxyethyl acrylate) Analog Polymers as Coating Materials 査読 国際誌

    6.R. Anjum, K. Nishida, H. Matsumoto, D. Murakami, S. Kobayashi, T. Anada, M. Tanaka

    Coatings   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Effects of Side-Chain Spacing and Length on Hydration States of the Poly(2-methoxyethyl acrylate) Analogs: A Molecular Dynamics Study 査読 国際誌

    A. T. Kuo, S. Urata, R. Koguchi, T. Sonoda, S. Kobayashi, M. Tanaka

    ACS Biomaterials Science & Engineering   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Different Hydration States and Passive Tumor Targeting Ability of Polyethylene Glycol-modified Dendrimers with High and Low PEG density 査読 国際誌

    A. Tsujimoto, H. Uehara, H. Yoshida, M. Nishio, K. Furuta, T. Inui, A. Matsumoto, S. Morita, M. Tanaka, C. Kojima

    Materials Science & Engineering C   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Chain-End Effect for Intermediate Water Formation of Poly(2-Methoxyethyl Acrylate)

    S. Nishimura, T. Ueda, D. Murakami, M. Tanaka

    Organic Materials   03 ( 02 )   214 - 220   2021年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-1441-8239

  • Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials

    Rubaiya Anjum, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, Masaru Tanaka

    Coatings   11 ( 4 )   461 - 461   2021年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/coatings11040461

  • Chain-End Effect for Intermediate Water Formation of Poly(2-Methoxyethyl Acrylate)

    S. Nishimura, T. Ueda, D. Murakami, M. Tanaka

    Organic Materials   03 ( 02 )   214 - 220   2021年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/a-1441-8239

  • Attachment and growth of fibroblast cells on poly (2-methoxyethyl acrylate) analog polymers as coating materials

    Rubaiya Anjum, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, Masaru Tanaka

    Coatings   11 ( 4 )   2021年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/coatings11040461

  • Chain End Effect for Intermediate Water Formation of Poly(2-methoxyethyl acrylate) 査読 国際誌

    S. Nishimura, T. Ueda, D. Murakami, M. Tanaka

    Organic Materials   2021年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization 査読 国際誌

    T. Sonoda, S. Kobayashi, M. Tanaka

    Macromolecules   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Periodically Functionalized Linear Polyethylene with Tertiary Amino Groups via Regioselective Ring-Opening Metathesis Polymerization

    Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   54 ( 6 )   2862 - 2872   2021年3月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.0c02611

  • Effect of interfacial structure based on grafting density of poly(2-methoxyethyl acrylate) on blood compatibility

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   199   2021年3月

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    DOI: 10.1016/j.colsurfb.2020.111517

  • Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property 査読 国際誌

    ACS Biomaterials Science & Engineering   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property

    Valentina Montagna, Junko Takahashi, Meng Yu Tsai, Takayuki Ota, Nicolas Zivic, Seigou Kawaguchi, Takashi Kato, Masaru Tanaka, Haritz Sardon, Kazuki Fukushima

    ACS Biomaterials Science and Engineering   7 ( 2 )   472 - 481   2021年2月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.0c01460

  • Role of Interfacial Water in Determining the Interaction of Proteins and Cells with Hydrated Materials 招待 査読 国際誌

    M. Tanaka, S. Morita, T. Hayashi

    Colloids and Surfaces B: Biointerfaces   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Effect of Interfacial Structure Based on Grafting Density of Poly(2-Methoxyethyl Acrylate) on Blood Compatibility 査読 国際誌

    T. Ueda, D. Murakami, M. Tanaka

    Colloids and Surfaces B: Biointerfaces   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition 査読 国際誌

    Y. Toyokawa, S. Kobayashi, H. Tsuchiya, T. Shibuya, M. Aoki, J. Sumiya, S. Ooyama, T. Ishizawa, N. Makino, Y. Ueno, M. Tanaka

    Materials Science & Engineering C   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • A fully covered self-expandable metallic stent coated with poly (2-methoxyethyl acrylate) and its derivative: In vitro evaluation of early-stage biliary sludge formation inhibition

    Yoshihide Toyokawa, Shingo Kobayashi, Haruka Tsuchiya, Tomokazu Shibuya, Makiko Aoki, Jun Sumiya, Shun Ooyama, Tetsuya Ishizawa, Naohiko Makino, Yoshiyuki Ueno, Masaru Tanaka

    Materials Science and Engineering: C   120   111386 - 111386   2021年1月

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    DOI: 10.1016/j.msec.2020.111386

  • Sulfated Hyaluronan coating of polyurethanebased implant materials 査読 国際誌

    K. Athanasopulu, D. Caltzidou, A. Sekishita, L. Kutuzova, G. Lorenz, M. Tanaka, R. Kemkemer

    Current Directions in Biomedical Engineering   2020年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  • Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s

    6 ( 12 )   6690 - 6700   2020年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.0c01220

  • Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s

    6 ( 12 )   6690 - 6700   2020年12月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.0c01220

  • Side chain spacing control of derivatives of poly(2-methoxyethyl acrylate): impact on hydration states and antithrombogenicity 招待 査読 国際誌

    T. Sonoda, S. Kobayashi, K. Herai, M. Tanaka

    Macromolecules   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Molecular Dynamics Study on the Water Mobility and Side-chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s 査読 国際誌

    2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Role of interfacial water in determining the interactions of proteins and cells with hydrated materials. 国際誌

    Masaru Tanaka, Shigeaki Morita, Tomohiro Hayashi

    Colloids and surfaces. B, Biointerfaces   198   111449 - 111449   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2020.111449

  • Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties

    Nishimura, S.-N., Ueda, T., Kobayashi, S., Tanaka, M.

    ACS Applied Polymer Materials   2 ( 11 )   4790 - 4801   2020年11月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsapm.0c00776

  • Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties

    Shin-nosuke Nishimura, Tomoya Ueda, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Polymer Materials   2 ( 11 )   4790 - 4801   2020年11月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsapm.0c00776

  • Silsesquioxane/Poly(2-methoxyethyl acrylate) Hybrid with Both Antithrombotic and Endothelial Cell Adhesive Properties 査読 国際誌

    S. Nishimura, T. Ueda, S. Kobayashi, M. Tanak

    ACS Applied Polymer Materials   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity

    Sonoda, T., Kobayashi, S., Herai, K., Tanaka, M.

    Macromolecules   53 ( 19 )   8570 - 8580   2020年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.0c01144

  • Side-Chain Spacing Control of Derivatives of Poly(2-methoxyethyl acrylate): Impact on Hydration States and Antithrombogenicity

    Toshiki Sonoda, Shingo Kobayashi, Keisuke Herai, Masaru Tanaka

    Macromolecules   53 ( 19 )   8570 - 8580   2020年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.0c01144

  • Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement 査読 国際誌

    2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement

    6 ( 7 )   3915 - 3924   2020年7月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.0c00746

  • Elucidating the Feature of Intermediate Water in Hydrated Poly(ω-methoxyalkyl acrylate)s by Molecular Dynamics Simulation and Differential Scanning Calorimetry Measurement 査読

    6 ( 7 )   3915 - 3924   2020年6月

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    DOI: 10.1021/acsbiomaterials.0c00746

  • Understanding the Effect of Hydration on the Bio-inert Properties of 2-Hydroxyethyl Methacrylate Copolymers with Small Amounts of Amino- or/and Fluorine-Containing Monomers

    Koguchi, R., Jankova, K., Hayasaka, Y., Kobayashi, D., Amino, Y., Miyajima, T., Kobayashi, S., Murakami, D., Yamamoto, K., Tanaka, M.

    ACS Biomaterials Science and Engineering   6 ( 5 )   2855 - 2866   2020年5月

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    DOI: 10.1021/acsbiomaterials.0c00230

  • Understanding the Effect of Hydration on the Bio-inert Properties of 2-Hydroxyethyl Methacrylate Copolymers with Small Amounts of Amino- or/and Fluorine-Containing Monomers 査読

    Ryohei Koguchi, Katja Jankova, Yuki Hayasaka, Daisuke Kobayashi, Yosuke Amino, Tatsuya Miyajima, Shingo Kobayashi, Daiki Murakami, Kyoko Yamamoto, Masaru Tanaka

    ACS Biomaterials Science & Engineering   6 ( 5 )   2855 - 2866   2020年5月

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    DOI: 10.1021/acsbiomaterials.0c00230

  • Understanding the effect of hydration on the bio-inert properties of HEMA copolymers with small amounts of amino- or/and fluorine-containing monomers 査読 国際誌

    R. Koguchi, K. Jankova, Y. Hayasaka, D. Kobayashi, Y. Amino, T. Miyajima, S. Kobayashi, D. Murakami, K. Yamamoto, M. Tanaka

    ACS Biomater. Sci. Eng.   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium 査読

    Meng Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium

    Meng-Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020年4月

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium 査読

    Meng Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020年4月

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium 査読

    Meng-Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020年4月

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    DOI: 10.1021/acsabm.9b00885

  • Blood-Compatible Poly(2-methoxyethyl acrylate) Induces Blebbing-like Phenomenon and Promotes Viability of Tumor Cells in Serum-Free Medium 査読

    Meng Yu Tsai, Fumihiro Aratsu, Shogo Sekida, Shingo Kobayashi, Masaru Tanaka

    ACS Applied Bio Materials   3 ( 4 )   1858 - 1864   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00885

  • Optimal Plasticizer Content for Magnetic Elastomers Used for Cell Culture Substrate 査読

    Mayuko Watanabe, Yukiko Tanaka, Daiki Murakami, Masaru Tanaka, Mika Kawai, Tetsu Mitsumata

    CHEMISTRY LETTERS   49 ( 3 )   280 - 283   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.190929

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers 査読 国際誌

    D. Murakami, Y. Segami, T. Ueda, M. Tanaka

    J. Biomater. Sci. Polym. Ed.   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Optimal plasticizer content for magnetic elastomers used for cell culture substrate 査読

    Mayuko Watanabe, Yukiko Tanaka, Daiki Murakami, Masaru Tanaka, Mika Kawai, Tetsu Mitsumata

    Chemistry Letters   49 ( 3 )   280 - 283   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.190929

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers

    Murakami, D., Segami, Y., Ueda, T., Tanaka, M.

    Journal of Biomaterials Science, Polymer Edition   31 ( 2 )   1 - 12   2020年1月

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    DOI: 10.1080/09205063.2019.1680930

  • Optimal plasticizer content for magnetic elastomers used for cell culture substrate 査読

    Mayuko Watanabe, Yukiko Tanaka, Daiki Murakami, Masaru Tanaka, Mika Kawai, Tetsu Mitsumata

    Chemistry Letters   49 ( 3 )   280 - 283   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.190929

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate) 査読

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00363

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019年10月

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    DOI: 10.1021/acsabm.9b00363

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019年10月

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    Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)
    Copyright © 2019 American Chemical Society. The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol &#37; of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of -35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.

    DOI: 10.1021/acsabm.9b00363

  • Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate) 査読

    Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

    ACS Applied Bio Materials   2 ( 10 )   4154 - 4161   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00363

  • Controlling the Hydration Structure with a Small Amount of Fluorine to Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate) 査読

    Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka

    Biomacromolecules   20 ( 6 )   2265 - 2275   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.9b00201

  • Controlling the Hydration Structure with a Small Amount of Fluorine To Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate)

    Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka

    Biomacromolecules   20 ( 6 )   2265 - 2275   2019年6月

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    DOI: 10.1021/acs.biomac.9b00201

  • Controlling the Hydration Structure with a Small Amount of Fluorine to Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate) 査読

    Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka

    Biomacromolecules   20 ( 6 )   2265 - 2275   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.9b00201

  • Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires 査読

    8 ( 10 )   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

    DOI: 10.1002/adhm.201900130

  • Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires 査読

    8 ( 10 )   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

    DOI: 10.1002/adhm.201900130

  • Controlling the Hydration Structure with a Small Amount of Fluorine to Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate) 査読

    Koguchi, R., Jankova, K., Tanabe, N., Amino, Y., Hayasaka, Y., Kobayashi, D., Miyajima, T., Yamamoto, K., Tanaka, M.

    Biomacromolecules   20 ( 6 )   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.9b00201

  • Long-Term Implantable, Flexible, and Transparent Neural Interface Based on Ag/Au Core–Shell Nanowires 査読

    8 ( 10 )   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Neural interfaces enabling light transmittance rely on optogenetics to control and monitor specific neural activity, thereby facilitating deeper understanding of intractable diseases. This study reports the material strategy underlying an optogenetic neural interface comprising stretchable and transparent conductive tracks and capable of demonstrating high biocompatibility after long-term (5-month) implantation. Ag/Au core–shell nanowires contribute toward improving track performance in terms of stretchability (<60% strain), transparency (<83%), and electrical resistance (15 Ω sq−1). The neural interface integrated with gel-coated exterior microelectrodes preserves low impedance (1.1–3.2 Ω cm2) in a saline solution over the evaluated 5-month period. Besides the use of efficient conductive materials, surface treatment using antithrombogenic polymer tends to prevent the growth of granulation tissue, thereby facilitating clear monitoring of electrocorticograms (ECoG) in a rodent during chronic implantation. The flexible and transparent neural interface pathologically exhibits noncytotoxicity and low inflammatory response while efficiently recording evoked ECoG in a nonhuman primate via optogenetic stimulation. The proposed highly reliable interface can be employed in multifaceted approaches for translational research based on chronic implants.

    DOI: 10.1002/adhm.201900130

  • Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation 査読

    An Tsung Kuo, Shingo Urata, Ryohei Koguchi, Kyoko Yamamoto, Masaru Tanaka

    polymer   170   76 - 84   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.polymer.2019.03.001

  • Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation 査読

    An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Kyoko Yamamoto, Masaru Tanaka

    Polymer   170   76 - 84   2019年4月

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    DOI: 10.1016/j.polymer.2019.03.001

  • Analyses of equilibrium water content and blood compatibility for Poly(2-methoxyethyl acrylate) by molecular dynamics simulation 査読

    An Tsung Kuo, Shingo Urata, Ryohei Koguchi, Kyoko Yamamoto, Masaru Tanaka

    polymer   170   76 - 84   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.polymer.2019.03.001

  • Intermediate water on calcium phosphate minerals ITS origin and role in crystal growth 査読

    Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

    ACS Applied Bio Materials   2 ( 3 )   981 - 986   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00014

  • Intermediate water on calcium phosphate minerals: ITS origin and role in crystal growth

    Okada, M., Hara, E.S., Kobayashi, D., Kai, S., Ogura, K., Tanaka, M., Matsumoto, T.

    ACS Applied Bio Materials   2 ( 3 )   981 - 986   2019年3月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00014

  • Intermediate Water on Calcium Phosphate Minerals: Its Origin and Role in Crystal Growth 査読

    Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

    ACS Applied Bio Materials   2   981 - 986   2019年3月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00014

  • Intermediate water on calcium phosphate minerals ITS origin and role in crystal growth 査読

    Masahiro Okada, Emilio Satoshi Hara, Daisuke Kobayashi, Shoki Kai, Keiko Ogura, Masaru Tanaka, Takuya Matsumoto

    ACS Applied Bio Materials   2 ( 3 )   981 - 986   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsabm.9b00014

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility 査読

    Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka

    Langmuir   35 ( 7 )   2808 - 2813   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.8b02971

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility

    Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka

    Langmuir   35 ( 7 )   2808 - 2813   2019年2月

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    DOI: 10.1021/acs.langmuir.8b02971

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility 査読

    Murakami, D., Mawatari, N., Sonoda, T., Kashiwazaki, A., Tanaka, M.

    Langmuir   35 ( 7 )   2808 - 2813   2019年2月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.8b02971

  • Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility 査読

    Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka

    Langmuir   35 ( 7 )   2808 - 2813   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.langmuir.8b02971

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers 査読

    Daiki Murakami, Yuto Segami, Tomoya Ueda, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2019.1680930

  • Design of Polymeric Biomaterials: The "Intermediate Water Concept"

    Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

    Bulletin of the Chemical Society of Japan   92 ( 12 )   2043 - 2057   2019年1月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    Design of Polymeric Biomaterials: The "Intermediate Water Concept"
    © 2019 The Chemical Society of Japan. When biomaterials come into contact with biological fluids, water molecules immediately adsorb onto the surface of the materials. To understand the origin of the crucial roles of water molecules in biological interfaces, it is necessary to relate particular states of hydration water to various physicochemical properties of hydrated polymers. Here, advances in the inter-mediate water concept are reviewed. This account provides an overview of the progress made in the design of multi-functional biomedical polymers by controlling the bio-interfacial water states. Using principles of intermediate water, which is common in hydrated biopolymers and only biocompatible synthetic polymers, we found the synthetic methodology to create novel biocompatible polymers moves toward a more high-throughput way.

    DOI: 10.1246/bcsj.20190274

  • Design of Polymeric Biomaterials The "Intermediate Water Concept" 査読

    Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

    Bulletin of the Chemical Society of Japan   92 ( 12 )   2043 - 2057   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/bcsj.20190274

  • Control of interfacial structures and anti-platelet adhesion property of blood-compatible random copolymers 査読

    Daiki Murakami, Yuto Segami, Tomoya Ueda, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   2019年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2019.1680930

  • Design of Polymeric Biomaterials The "Intermediate Water Concept" 査読

    Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

    Bulletin of the Chemical Society of Japan   92 ( 12 )   2043 - 2057   2019年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/bcsj.20190274

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping 査読

    Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

    Science Advances   4 ( 10 )   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1126/sciadv.aau2426

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping

    Masaru Tanaka

    Science Advances   2018年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping 査読

    Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

    Science Advances   4 ( 10 )   2018年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1126/sciadv.aau2426

  • A Nonthrombogenic, Stretchable, Active Multielectrode Array using Organic Electrochemical Transistors 査読

    W. Lee, S. Kobayashi, M. Nagase, Y. Jimbo, I. Saito, Y. Inoue, T. Yambe, M. Sekino, G. G Malliaras, T. Yokota, M. Tanaka, T. Someya

    Science Advances   4 ( 10 )   eaau2426   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A Nonthrombogenic, Stretchable, Active Multielectrode Array using Organic Electrochemical Transistors

    DOI: 10.1126/sciadv.aau2426

  • Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping 査読

    Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

    Science Advances   4 ( 10 )   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1126/sciadv.aau2426

  • Hydrogel Preparation and Characterisation Derived from Chitosan and Amino Functional Monomers for Biomedical Applications 査読

    Masaru Tanaka

    Journal of Materials Chemistry B   6   5115   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Hydrogel Preparation and Characterisation Derived from Chitosan and Amino Functional Monomers for Biomedical Applications 査読

    Masaru Tanaka

    Journal of Materials Chemistry B   6   5115   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Newly developed controlled release subcutaneous formulation for tramadol hydrochloride 査読

    Mostafa Mabrouk, Hanan H. Beherei, Shaimaa ElShebiney, Masaru Tanaka

    Saudi Pharmaceutical Journal   26 ( 4 )   585 - 592   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsps.2018.01.014

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface 査読

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   4 ( 5 )   1591 - 1597   2018年5月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.8b00081

  • Newly developed controlled release subcutaneous formulation for tramadol hydrochloride 査読

    Mostafa Mabrouk, Hanan H. Beherei, Shaimaa ElShebiney, Masaru Tanaka

    Saudi Pharmaceutical Journal   26 ( 4 )   585 - 592   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsps.2018.01.014

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface 査読

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   4 ( 5 )   1591 - 1597   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.8b00081

  • Newly developed controlled release subcutaneous formulation for tramadol hydrochloride 査読

    Mostafa Mabrouk, Hanan H. Beherei, Shaimaa ElShebiney, Masaru Tanaka

    Saudi Pharmaceutical Journal   26 ( 4 )   585 - 592   2018年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsps.2018.01.014

  • Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

    Daiki Murakami, Yoko Kitahara, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science & Engineering   2018年4月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.8b00081

  • Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate 査読

    Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Chemistry Letters   47 ( 1 )   107 - 109   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.170889

  • Designing smart biomaterials for tissue engineering 査読

    Ferdous Khan, Masaru Tanaka

    International Journal of Molecular Sciences   19 ( 1 )   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms19010017

  • Designing smart biomaterials for tissue engineering 査読

    Ferdous Khan, Masaru Tanaka

    International journal of molecular sciences   19 ( 1 )   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms19010017

  • Design of multifunctional soft biomaterials Based on the intermediate water concept

    Masaru Tanaka

    New Polymeric Materials Based on Element-Blocks   423 - 432   2018年1月

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    記述言語:英語  

    DOI: 10.1007/978-981-13-2889-3_23

  • Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate 査読

    Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Chemistry Letters   47 ( 1 )   107 - 109   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.170889

  • Analysis of interaction between interfacial structure and fibrinogen at blood-compatible polymer/water interface 査読

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Frontiers in Chemistry   6   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3389/fchem.2018.00542

  • A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications 査読

    Ferdous Khan, Fumihiro Aratsu, Shingo Kobayashi, Masaru Tanaka

    Journal of Materials Chemistry B   6 ( 31 )   5115 - 5129   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c8tb00865e

  • Designing smart biomaterials for tissue engineering 査読

    Ferdous Khan, Masaru Tanaka

    International journal of molecular sciences   19 ( 1 )   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms19010017

  • Design of multifunctional soft biomaterials Based on the intermediate water concept

    Masaru Tanaka

    New Polymeric Materials Based on Element-Blocks   423 - 432   2018年1月

     詳細を見る

    記述言語:英語  

    DOI: 10.1007/978-981-13-2889-3_23

  • Chondrocyte shapes and detachment on a thermoresponsive poly(2-methoxyethyl acrylate) analog for the development of new chondrocytes subculture substrate 査読

    Takashi Hoshiba, Kazuhiro Sato, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Chemistry Letters   47 ( 1 )   107 - 109   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1246/cl.170889

  • Analysis of interaction between interfacial structure and fibrinogen at blood-compatible polymer/water interface 査読

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Frontiers in Chemistry   6   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3389/fchem.2018.00542

  • A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications 査読

    Ferdous Khan, Fumihiro Aratsu, Shingo Kobayashi, Masaru Tanaka

    Journal of Materials Chemistry B   6 ( 31 )   5115 - 5129   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c8tb00865e

  • Design of multifunctional soft biomaterials Based on the intermediate water concept

    Masaru Tanaka

    New Polymeric Materials Based on Element-Blocks   423 - 432   2018年1月

     詳細を見る

    記述言語:英語  

    DOI: 10.1007/978-981-13-2889-3_23

  • Analysis of interaction between interfacial structure and fibrinogen at blood-compatible polymer/water interface 査読

    Tomoya Ueda, Daiki Murakami, Masaru Tanaka

    Frontiers in Chemistry   6   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3389/fchem.2018.00542

  • A simple strategy for robust preparation and characterisation of hydrogels derived from chitosan and amino functional monomers for biomedical applications 査読

    Ferdous Khan, Fumihiro Aratsu, Shingo Kobayashi, Masaru Tanaka

    Journal of Materials Chemistry B   6 ( 31 )   5115 - 5129   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c8tb00865e

  • Designing smart biomaterials for tissue engineering 査読

    Ferdous Khan, Masaru Tanaka

    International Journal of Molecular Sciences   19 ( 1 )   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/ijms19010017

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers 査読

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Macromolecular Bioscience   17 ( 12 )   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.201700297

  • Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic Polymer Family with Tunable Protein Adsorption 査読

    18 ( 12 )   4214 - 4223   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b01247

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers 査読

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    MACROMOLECULAR BIOSCIENCE   17 ( 12 )   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.201700304

  • Poly(ω-methoxyalkyl acrylate)s Nonthrombogenic Polymer Family with Tunable Protein Adsorption 査読

    18 ( 12 )   4214 - 4223   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of polyacrylates with different n-alkyl side chain lengths (1 to 6, and 12 carbons) and a ω-methoxy terminal group (poly(ω-methoxyalkyl acrylate): PMCxA) were prepared to study their nonthrombogenicity using human platelet adhesion, micro bicinchoninic acid (micro BCA) protein assay, and enzyme-linked immunosorbent assay (ELISA) tests. In all cases, human platelet adhesion was suppressed on the PMCxA-coated substrates, and the number of human platelets adhered to the PMC3A (poly(3-methoxypropyl acrylate))-coated surface was comparable to that of commercialized nonthrombogenic coating agent poly(2-methoxyethyl acrylate) (PMEA, equal to PMC2A). The amount of protein adsorbed onto the PMCxA was investigated by micro BCA using bovine serum albumin (BSA) and human fibrinogen (hFbn), revealing that PMC3A exhibited significantly high resistance to nonspecific BSA adsorption. Additionally, the amount of hFbn adsorbed onto the PMC3A was suppressed to the same extent as PMEA. The exposure degree of platelet adhesion sites in adsorbed hFbn was evaluated using an ELISA test, and the degree on the PMCxA with three to six methylene carbons was comparable to the PMEA. The hydration water structure in the hydrated PMCxA was also characterized using differential scanning calorimetry (DSC). The amount of intermediate water, which is the hydration water molecules that moderately interact with the polymer matrix, was maximum in the PMEA with two methylene run lengths, whereas the amount decreased by increasing the number of methyelnes in the side chain. The amount of adsorbed protein increased with a decrease in the amount of intermediate water, suggesting that the protein adsorption amount is tunable by simply changing the number of methylene carbons in the side chain. The present study revealed that poly(ω-methoxyalkyl acrylate)s are useful for blood-contacting medical devices, and PMC3A is the best mode of PMCxA to apply as an antiprotein adsorption coating agent.

    DOI: 10.1021/acs.biomac.7b01247

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers 査読

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Macromolecular Bioscience   17 ( 12 )   2017年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.201700297

  • Poly(ω-methoxyalkyl acrylate)s Nonthrombogenic Polymer Family with Tunable Protein Adsorption 査読

    18 ( 12 )   4214 - 4223   2017年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of polyacrylates with different n-alkyl side chain lengths (1 to 6, and 12 carbons) and a ω-methoxy terminal group (poly(ω-methoxyalkyl acrylate): PMCxA) were prepared to study their nonthrombogenicity using human platelet adhesion, micro bicinchoninic acid (micro BCA) protein assay, and enzyme-linked immunosorbent assay (ELISA) tests. In all cases, human platelet adhesion was suppressed on the PMCxA-coated substrates, and the number of human platelets adhered to the PMC3A (poly(3-methoxypropyl acrylate))-coated surface was comparable to that of commercialized nonthrombogenic coating agent poly(2-methoxyethyl acrylate) (PMEA, equal to PMC2A). The amount of protein adsorbed onto the PMCxA was investigated by micro BCA using bovine serum albumin (BSA) and human fibrinogen (hFbn), revealing that PMC3A exhibited significantly high resistance to nonspecific BSA adsorption. Additionally, the amount of hFbn adsorbed onto the PMC3A was suppressed to the same extent as PMEA. The exposure degree of platelet adhesion sites in adsorbed hFbn was evaluated using an ELISA test, and the degree on the PMCxA with three to six methylene carbons was comparable to the PMEA. The hydration water structure in the hydrated PMCxA was also characterized using differential scanning calorimetry (DSC). The amount of intermediate water, which is the hydration water molecules that moderately interact with the polymer matrix, was maximum in the PMEA with two methylene run lengths, whereas the amount decreased by increasing the number of methyelnes in the side chain. The amount of adsorbed protein increased with a decrease in the amount of intermediate water, suggesting that the protein adsorption amount is tunable by simply changing the number of methylene carbons in the side chain. The present study revealed that poly(ω-methoxyalkyl acrylate)s are useful for blood-contacting medical devices, and PMC3A is the best mode of PMCxA to apply as an antiprotein adsorption coating agent.

    DOI: 10.1021/acs.biomac.7b01247

  • Maintenance of Cartilaginous Gene Expression of Serially Subcultured Chondrocytes on Poly(2-Methoxyethyl Acrylate) Analogous Polymers 査読

    Takashi Hoshiba, Hiroka Maruyama, Kazuhiro Sato, Chiho Endo, Naoki Kawazoe, Guoping Chen, Masaru Tanaka

    Macromolecular Bioscience   17 ( 12 )   2017年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.201700297

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion A Promising Material for Resorbable Vascular Grafts and Stents 査読

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    Biomacromolecules   18 ( 11 )   3834 - 3843   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b01210

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents 査読

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    BIOMACROMOLECULES   18 ( 11 )   3834 - 3843   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b01210

  • Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion A Promising Material for Resorbable Vascular Grafts and Stents 査読

    Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka

    Biomacromolecules   18 ( 11 )   3834 - 3843   2017年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b01210

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts 査読

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    European Polymer Journal   95   728 - 736   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts 査読

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    European Polymer Journal   95   728 - 736   2017年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts 査読

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    European Polymer Journal   95   728 - 736   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Synthesis of antithrombotic poly(carbonate-urethane)s through a sequential process of ring-opening polymerization and polyaddition facilitated by organocatalysts 査読

    Kazuki Fukushima, Kota Honda, Yuto Inoue, Masaru Tanaka

    EUROPEAN POLYMER JOURNAL   95   728 - 736   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2017.07.001

  • Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers 査読

    Takashi Hoshiba, Ayano Yoshihiro, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   986 - 999   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2017.1312738

  • Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers mechanisms underlying the effect of lateral packing density on bioinertness 査読

    Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   1231 - 1243   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2017.1303120

  • Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers 査読

    Takashi Hoshiba, Ayano Yoshihiro, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   986 - 999   2017年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2017.1312738

  • Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers mechanisms underlying the effect of lateral packing density on bioinertness 査読

    Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   1231 - 1243   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2017.1303120

  • Evaluation of initial cell adhesion on poly (2-methoxyethyl acrylate) (PMEA) analogous polymers 査読

    Takashi Hoshiba, Ayano Yoshihiro, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   986 - 999   2017年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2017.1312738

  • Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers mechanisms underlying the effect of lateral packing density on bioinertness 査読

    Taito Sekine, Syifa Asatyas, Chikako Sato, Shigeaki Morita, Masaru Tanaka, Tomohiro Hayashi

    Journal of Biomaterials Science, Polymer Edition   28 ( 10-12 )   1231 - 1243   2017年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/09205063.2017.1303120

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime 査読

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    Annals of Biomedical Engineering   45 ( 5 )   1352 - 1364   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10439-016-1781-5

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester): A Candidate for Blood-Compatible Polymers 査読

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    BIOMACROMOLECULES   18 ( 5 )   1609 - 1616   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b00221

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime 査読

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    ANNALS OF BIOMEDICAL ENGINEERING   45 ( 5 )   1352 - 1364   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10439-016-1781-5

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester) A Candidate for Blood-Compatible Polymers 査読

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    Biomacromolecules   18 ( 5 )   1609 - 1616   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b00221

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime 査読

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    Annals of Biomedical Engineering   45 ( 5 )   1352 - 1364   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10439-016-1781-5

  • Synthesis and Thrombogenicity Evaluation of Poly(3-methoxypropionic acid vinyl ester) A Candidate for Blood-Compatible Polymers 査読

    Kazuhiro Sato, Shingo Kobayashi, Asuka Sekishita, Miyuki Wakui, Masaru Tanaka

    Biomacromolecules   18 ( 5 )   1609 - 1616   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.7b00221

  • Antithrombotic Protein Filter Composed of Hybrid Tissue-Fabric Material has a Long Lifetime 査読

    Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino

    Annals of Biomedical Engineering   45 ( 5 )   1352 - 1364   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10439-016-1781-5

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy 査読 国際誌

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   19 ( 2 )   1389 - 1394   2017年4月

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    DOI: 10.1039/c6cp07322k

  • Applications of functionalized biodegradable polymers in tissue engineering and regenerative medicine 査読

    Fukushima Kazuki, Inoue Yuto, Haga Yuta, Oji Masashi, Takaoka Shunya, Sato Chikako, Tsuchiya Haruka, Tanaka Masaru

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   253   2017年4月

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    記述言語:その他  

    Applications of functionalized biodegradable polymers in tissue engineering and regenerative medicine

  • Design Concept of Dialyzer Biomaterials How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure 査読

    Masaru Tanaka

    Contributions to Nephrology   189   137 - 143   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000451043

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy 査読

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    PHYSICAL CHEMISTRY CHEMICAL PHYSICS   19 ( 2 )   1389 - 1394   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c6cp07322k

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy 査読

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   19 ( 2 )   1389 - 1394   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c6cp07322k

  • Design Concept of Dialyzer Biomaterials How to Find Biocompatible Polymers Based on the Biointerfacial Water Structure 査読

    Masaru Tanaka

    Contributions to Nephrology   189   137 - 143   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000451043

  • Dynamics of a bioinert polymer in hydrated states by dielectric relaxation spectroscopy 査読

    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Manabu Inutsuka, Tomoyasu Hirai, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   19 ( 2 )   1389 - 1394   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c6cp07322k

  • Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces 査読

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   2 ( 12 )   2122 - 2126   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.6b00415

  • Interfacial Structures and Fibrinogen Adsorption at Blood Compatible Polymer/Water Interfaces 査読

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS BIOMATERIALS SCIENCE & ENGINEERING   2 ( 12 )   2122 - 2126   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.6b00415

  • Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces 査読

    Daiki Murakami, Shingo Kobayashi, Masaru Tanaka

    ACS Biomaterials Science and Engineering   2 ( 12 )   2122 - 2126   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acsbiomaterials.6b00415

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst 査読

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    European Polymer Journal   84   750 - 758   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2016.08.008

  • 再生医療・組織工学 中間水含有高分子による軟骨細胞の形態制御を通じた機能維持可能な継代培養基板の開発

    丸山 寛花, 干場 隆志, 佐藤 一博, 陳 国平, 田中 賢

    日本バイオマテリアル学会大会予稿集   シンポジウム2016   97 - 97   2016年11月

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    記述言語:日本語  

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene 査読

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    MACROMOLECULES   49 ( 21 )   8154 - 8161   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.6b01829

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption Suppressing Poly(2-methoxyethyl acrylate) Analogs 査読

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    BIOMACROMOLECULES   17 ( 11 )   3808 - 3815   2016年11月

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    DOI: 10.1021/acs.biomac.6b01340

  • Integrin-independent Cell Adhesion Substrates: Possibility of Applications for Mechanobiology Research 査読

    Takashi Hoshiba, Masaru Tanaka

    ANALYTICAL SCIENCES   32 ( 11 )   1151 - 1158   2016年11月

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    記述言語:英語  

    DOI: 10.2116/analsci.32.1151

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells 査読

    Takashi Hoshiba, Masaru Tanaka

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1863 ( 11 )   2749 - 2757   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbamcr.2016.08.009

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst 査読

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    EUROPEAN POLYMER JOURNAL   84   750 - 758   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2016.08.008

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene 査読

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   49 ( 21 )   8154 - 8161   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.6b01829

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs 査読

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    Biomacromolecules   17 ( 11 )   3808 - 3815   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.6b01340

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels Mechanism of 5-fluorouracil resistance in colorectal tumor cells 査読

    Takashi Hoshiba, Masaru Tanaka

    Biochimica et Biophysica Acta - Molecular Cell Research   1863 ( 11 )   2749 - 2757   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbamcr.2016.08.009

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst 査読

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    European Polymer Journal   84   750 - 758   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2016.08.008

  • Synthesis of Sequence-Specific Polymers with Amide Side Chains via Regio-/Stereoselective Ring-Opening Metathesis Polymerization of 3-Substituted cis-Cyclooctene 査読

    Kohei Osawa, Shingo Kobayashi, Masaru Tanaka

    Macromolecules   49 ( 21 )   8154 - 8161   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.macromol.6b01829

  • Promotion of Adipogenesis of 3T3-L1 Cells on Protein Adsorption-Suppressing Poly(2-methoxyethyl acrylate) Analogs 査読

    Takashi Hoshiba, Eri Nemoto, Kazuhiro Sato, Hiroka Maruyama, Chiho Endo, Masaru Tanaka

    Biomacromolecules   17 ( 11 )   3808 - 3815   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/acs.biomac.6b01340

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels Mechanism of 5-fluorouracil resistance in colorectal tumor cells 査読

    Takashi Hoshiba, Masaru Tanaka

    Biochimica et Biophysica Acta - Molecular Cell Research   1863 ( 11 )   2749 - 2757   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbamcr.2016.08.009

  • Biocompatibility and hemocompatibility evaluation of polyether urethanes synthesized using DBU organocatalyst 査読

    Andere Basterretxea, Yuta Haga, Ana Sanchez-Sanchez, Mehmet Isik, Lourdes Irusta, Masaru Tanaka, Kazuki Fukushima, Haritz Sardon

    European Polymer Journal   84   750 - 758   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.eurpolymj.2016.08.008

  • Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels Mechanism of 5-fluorouracil resistance in colorectal tumor cells 査読

    Takashi Hoshiba, Masaru Tanaka

    Biochimica et Biophysica Acta - Molecular Cell Research   1863 ( 11 )   2749 - 2757   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbamcr.2016.08.009

  • H. Choi, M. Tanaka, K. Sugimoto, Difference in cell proliferation and spontaneous mediator release between two mast cell lines, NCL-2 and RBL-2H3 on honeycomb-like structured film 招待 査読 国際誌

    Masaru Tanaka

    Journal of Nanotechnology: Nanomedicine & Nanobiotechnology   3 ( 009 )   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. 査読

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   145   586 - 596   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. 査読

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    COLLOIDS AND SURFACES B-BIOINTERFACES   145   586 - 596   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. 査読

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   145   586 - 596   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly(2-methoxyethyl acrylate) for the adhesion and proliferation of endothelial and smooth muscle cells. 査読

    Chikako Sato, Makiko Aoki, Masaru Tanaka

    Colloids and Surfaces B: Biointerfaces   145   586 - 596   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfb.2016.05.057

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells 査読

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    Journal of Bioactive and Compatible Polymers   31 ( 4 )   361 - 372   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/0883911515618976

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells 査読

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS   31 ( 4 )   361 - 372   2016年7月

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    DOI: 10.1177/0883911515618976

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells 査読

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    Journal of Bioactive and Compatible Polymers   31 ( 4 )   361 - 372   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/0883911515618976

  • Blood-compatible poly (2-methoxyethyl acrylate) for the adhesion and proliferation of lung cancer cells toward the isolation and analysis of circulating tumor cells 査読

    Takashi Hoshiba, Mayo Nikaido, Satomi Yagi, Iku Konno, Ayano Yoshihiro, Masaru Tanaka

    Journal of Bioactive and Compatible Polymers   31 ( 4 )   361 - 372   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/0883911515618976

  • In vitro endothelialization test of biomaterials using immortalized endothelial cells 査読

    Ken Kono, Hitomi Hiruma, Shingo Kobayashi, Yoji Sato, Masaru Tanaka, Rumi Sawada, Shingo Niimi

    PLoS One   11 ( 6 )   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0158289

  • In Vitro Endothelialization Test of Biomaterials Using Immortalized Endothelial Cells 査読

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    DOI: 10.1021/acs.macromol.6b00273

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    DOI: 10.1021/acs.macromol.6b00273

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    Macromolecules   49 ( 7 )   2493 - 2501   2016年4月

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    DOI: 10.1021/acs.macromol.6b00273

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    DOI: 10.1039/c6ra15229e

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    DOI: 10.1155/2016/6397820

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    Takashi Hoshiba, Toshihiko Orui, Chiho Endo, Kazuhiro Sato, Ayano Yoshihiro, Yasuhisa Minagawa, Masaru Tanaka

    RSC Advances   6 ( 92 )   89103 - 89112   2016年1月

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    DOI: 10.1039/c6ra15229e

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    Takashi Hoshiba, Masaru Tanaka

    Analytical Sciences   32 ( 11 )   1151 - 1158   2016年1月

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    DOI: 10.2116/analsci.32.1151

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    DOI: 10.1155/2016/6397820

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    Takashi Hoshiba, Toshihiko Orui, Chiho Endo, Kazuhiro Sato, Ayano Yoshihiro, Yasuhisa Minagawa, Masaru Tanaka

    RSC Advances   6 ( 92 )   89103 - 89112   2016年1月

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    DOI: 10.1039/c6ra15229e

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    DOI: 10.2116/analsci.32.1151

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    Masaru Tanaka

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    DOI: 10.1159/000451043

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    Takashi Hoshiba, Guoping Chen, Chiho Endo, Hiroka Maruyama, Miyuki Wakui, Eri Nemoto, Naoki Kawazoe, Masaru Tanaka

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    DOI: 10.1155/2016/6397820

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    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

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  • Construction of a blood-compatible interface based on surface segregation in a polymer blend 査読

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    POLYMER   78   219 - 224   2015年11月

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    DOI: 10.1016/j.polymer.2015.10.001

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    Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

    polymer   78   219 - 224   2015年11月

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    DOI: 10.1016/j.polymer.2015.10.001

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    Polymer   78   219 - 224   2015年11月

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    DOI: 10.1016/j.polymer.2015.10.001

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    Macromolecular Bioscience   15 ( 9 )   1296 - 1303   2015年9月

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    DOI: 10.1002/mabi.201500078

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    DOI: 10.1039/c5tb01370d

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    DOI: 10.1021/acsami.5b05210

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    DOI: 10.1039/c5tb01370d

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    ACS Applied Materials and Interfaces   7 ( 32 )   18096 - 18103   2015年8月

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    DOI: 10.1021/acsami.5b05210

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    DOI: 10.1039/c5tb01370d

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    ACS Applied Materials and Interfaces   7 ( 32 )   18096 - 18103   2015年8月

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    DOI: 10.1021/acsami.5b05210

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    DOI: 10.1371/journal.pone.0136066

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    DOI: 10.1039/c5cp01972a

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    POLYMER JOURNAL   47 ( 7 )   469 - 473   2015年7月

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    DOI: 10.1038/pj.2015.22

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    DOI: 10.1038/pj.2015.22

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    T. Hirata, H. Matsuno, D. Kawaguchi, N. L. Yamada, M. Tanaka, K. Tanaka

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    DOI: 10.1039/c5cp01972a

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    DOI: 10.1038/pj.2015.22

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    T. Hirata, Hisao Matsuno, Daisuke Kawaguchi, N. L. Yamada, Masaru Tanaka, Keiji Tanaka

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    DOI: 10.1039/c5cp01972a

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    DOI: 10.1038/pj.2015.22

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    Langmuir   31 ( 25 )   7100 - 7105   2015年6月

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    DOI: 10.1021/acs.langmuir.5b01216

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    DOI: 10.1021/acs.langmuir.5b01216

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    DOI: 10.1021/acs.langmuir.5b01216

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    DOI: 10.1021/acs.langmuir.5b00258

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    DOI: 10.1021/acs.langmuir.5b00258

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    DOI: 10.1021/acs.langmuir.5b00258

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    DOI: 10.1016/j.bbrc.2014.12.116

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    DOI: 10.1016/j.bbrc.2014.12.116

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    DOI: 10.1038/pj.2014.129

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    DOI: 10.1016/j.bbrc.2014.12.116

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    Polymer Journal   47 ( 2 )   114 - 121   2015年2月

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    DOI: 10.1038/pj.2014.129

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    DOI: 10.1016/j.bbrc.2014.12.116

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    DOI: 10.1038/pj.2014.129

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    DOI: 10.1038/pj.2014.129

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    DOI: 10.1021/la502550d

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    DOI: 10.1021/la502550d

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    Langmuir   30 ( 35 )   10698 - 10703   2014年9月

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    DOI: 10.1021/la502550d

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    記述言語:その他  

    Facile and practical route to a versatile intermediate of substituted cyclic carbonates offering diverse smart biomaterials

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    Advanced Healthcare Materials   3 ( 5 )   775 - 784   2014年5月

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    DOI: 10.1002/adhm.201300309

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    DOI: 10.1002/adhm.201300309

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    DOI: 10.1016/j.nano.2013.08.011

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    DOI: 10.1016/j.nano.2013.08.011

  • Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate with multinucleated formation 査読

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    Nanomedicine: Nanotechnology, Biology, and Medicine   10 ( 2 )   313 - 319   2014年2月

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    DOI: 10.1016/j.nano.2013.08.011

  • Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate) 査読

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    DOI: 10.1155/2014/102648

  • 平成25年度日韓バイオマテリアル学会若手研究者交流AWARD 血液適合性高分子PMEAへのがん細胞の接着機構の解析 (特集 平成25年度日本バイオマテリアル学会各賞紹介)

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  • Biocompatible 2D and 3D polymeric scaffolds for medical devices 査読

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    DOI: 10.4032/9789814411578

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    DOI: 10.4032/9789814411578

  • Adhesion and proliferation of human periodontal ligament cells on poly(2-methoxyethyl acrylate) 査読

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    DOI: 10.1155/2014/102648

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    DOI: 10.1155/2014/710354

  • Characterization of the attachment mechanisms of tissue-derived cell lines to blood-compatible polymers 査読

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    DOI: 10.1002/adhm.201300309

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    DOI: 10.4032/9789814411578

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    DOI: 10.1155/2014/102648

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    DOI: 10.1155/2014/710354

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    DOI: 10.4032/9789814411578

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    DOI: 10.1155/2014/710354

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    DOI: 10.1039/c3cp90155f

  • Erratum Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: Protein adsorption, platelet adhesion, and surface forces (Physical Chemistry Chemical Physics (2012) 14 (10196-10206) DOI: 10.1039/C2CP41236E) 査読

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    Physical Chemistry Chemical Physics   15 ( 48 )   2013年12月

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    DOI: 10.1039/c3cp90155f

  • Erratum Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold: Protein adsorption, platelet adhesion, and surface forces (Physical Chemistry Chemical Physics (2012) 14 (10196-10206) DOI: 10.1039/C2CP41236E) 査読

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    DOI: 10.1039/c3cp90155f

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    DOI: 10.1016/j.bbrc.2013.08.038

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    DOI: 10.1089/ten.tea.2012.0729

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    DOI: 10.1016/j.bbrc.2013.08.038

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    Fukushima Kazuki, Inoue Yuto, Tanaka Masaru

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    DOI: 10.1089/ten.tea.2012.0729

  • Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages 査読

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    Biochemical and Biophysical Research Communications   439 ( 2 )   291 - 296   2013年9月

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    DOI: 10.1016/j.bbrc.2013.08.038

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    Tissue Engineering - Part A   19 ( 17-18 )   2087 - 2096   2013年9月

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    DOI: 10.1089/ten.tea.2012.0729

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    DOI: 10.1016/j.bbrc.2013.08.038

  • Microporous "honeycomb" films support enhanced bone formation in vitro 査読

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    Tissue Engineering - Part A.   19 ( 17-18 )   2087 - 2096   2013年9月

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    DOI: 10.1089/ten.tea.2012.0729

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    DOI: 10.1038/pj.2012.229

  • The roles of water molecules at the biointerface of medical polymers 査読

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    DOI: 10.1038/pj.2012.229

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    DOI: 10.1038/pj.2012.229

  • The roles of water molecules at the biointerface of medical polymers 査読

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    Polymer Journal   45 ( 7 )   701 - 710   2013年7月

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    DOI: 10.1038/pj.2012.229

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  • 動的ナノ界面が生み出すバイオマテリアル機能 培養中のバイオマテリアル界面変化を利用した培養基板の作製

    干場 隆志, 田中 賢, 陳 国平

    日本バイオマテリアル学会大会予稿集   シンポジウム2012   137 - 137   2012年11月

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    記述言語:日本語  

  • Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold Protein adsorption, platelet adhesion, and surface forces 査読

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   14 ( 29 )   10196 - 10206   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2cp41236e

  • Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold Protein adsorption, platelet adhesion, and surface forces 査読

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   14 ( 29 )   10196 - 10206   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2cp41236e

  • Mechanism underlying bioinertness of self-assembled monolayers of oligo(ethyleneglycol)-terminated alkanethiols on gold Protein adsorption, platelet adhesion, and surface forces 査読

    Tomohiro Hayashi, Yusaku Tanaka, Yuki Koide, Masaru Tanaka, Masahiko Hara

    Physical Chemistry Chemical Physics   14 ( 29 )   10196 - 10206   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c2cp41236e

  • Comparison of measurement techniques for the identification of bound water restrained by polymers 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    Thermochimica Acta   532   159 - 163   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2011.01.027

  • Comparison of measurement techniques for the identification of bound water restrained by polymers 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    THERMOCHIMICA ACTA   532   159 - 163   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2011.01.027

  • Comparison of measurement techniques for the identification of bound water restrained by polymers 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    Thermochimica Acta   532   159 - 163   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2011.01.027

  • Comparison of measurement techniques for the identification of bound water restrained by polymers 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Akira Kishi, Hyoe Hatakeyama

    Thermochimica Acta   532   159 - 163   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2011.01.027

  • Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure 査読

    Macromolecular Rapid Communications   33 ( 4 )   319 - 325   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/marc.201100698

  • 高分子/水界面における凝集構造と生体適合性(バイオテクノロジー,有機エレクトロニクス,界面,一般)

    松野 寿生, 平田 豊章, 田中 賢, 田中 敬二

    電子情報通信学会技術研究報告. OME, 有機エレクトロニクス   111 ( 440 )   37 - 38   2012年2月

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    記述言語:日本語  

    安定かつ平坦なポリ(アクリル酸2-メトキシエチル)(PMEA)表面を,ポリメタクリル酸メチル(PMMA)とブレンドすることで作製した.水中におけるPMEA/PMMAブレンド膜に対する気泡接触角は時間依存的に変化し,水界面近傍における分子鎖凝集構造が再編成されることが分かった.PMEA/PMMAブレンド表面は,従来のPMEA膜と同等以上の血小板粘着抑制能を示し,優れた血液適合性を有することが分かった.

  • Synthesis of Graft Copolymers Based on Poly(2-Methoxyethyl Acrylate) and Investigation of the Associated Water Structure 査読

    Irakli Javakhishvili, Masaru Tanaka, Keiko Ogura, Katja Jankova, Soren Hvilsted

    MACROMOLECULAR RAPID COMMUNICATIONS   33 ( 4 )   319 - 325   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/marc.201100698

  • Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure 査読

    Macromolecular rapid communications   33 ( 4 )   319 - 325   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/marc.201100698

  • Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure 査読

    Macromolecular rapid communications   33 ( 4 )   319 - 325   2012年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/marc.201100698

  • Thermal Characterization of Novel Polymers for Biomedical Applications 査読

    Masaru Tanaka

    Netsu Sokutei   151   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Thermal Characterization of Novel Polymers for Biomedical Applications 査読

    Masaru Tanaka

    Netsu Sokutei   151   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Thermal Characterization of Novel Polymers for Biomedical Applications 査読

    Masaru Tanaka

    Netsu Sokutei   151   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Water structure and polymer dynamics in hydrated blood compatible polymers 査読

    Yuko Miwa, Masaru Tanaka, Akira Mochizuki

    Kobunshi Ronbunshu   68 ( 4 )   133 - 146   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1295/koron.68.133

  • Water structure and polymer dynamics in hydrated blood compatible polymers 査読

    Yuko Miwa, Masaru Tanaka, Akira Mochizuki

    KOBUNSHI RONBUNSHU   68 ( 4 )   133 - 146   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1295/koron.68.133

  • Water structure and polymer dynamics in hydrated blood compatible polymers 査読

    Yuko Miwa, Masaru Tanaka, Akira Mochizuki

    KOBUNSHI RONBUNSHU   68 ( 4 )   133 - 146   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1295/koron.68.133

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior 査読

    Masaru Tanaka

    Biochimica et Biophysica Acta - General Subjects   1810 ( 3 )   251 - 258   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbagen.2010.10.002

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior 査読

    Masaru Tanaka

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   1810 ( 3 )   251 - 258   2011年3月

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    記述言語:英語  

    DOI: 10.1016/j.bbagen.2010.10.002

  • Surface segregation of poly(2-methoxyethyl acrylate) in a mixture with poly(methyl methacrylate) 査読

    Toyoaki Hirata, Hisao Matsuno, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   13 ( 11 )   4928 - 4934   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c0cp02101f

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior 査読

    Masaru Tanaka

    Biochimica et Biophysica Acta - General Subjects   1810 ( 3 )   251 - 258   2011年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbagen.2010.10.002

  • Surface segregation of poly(2-methoxyethyl acrylate) in a mixture with poly(methyl methacrylate) 査読

    Toyoaki Hirata, Hisao Matsuno, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   13 ( 11 )   4928 - 4934   2011年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c0cp02101f

  • Design of novel 2D and 3D biointerfaces using self-organization to control cell behavior 査読

    Masaru Tanaka

    Biochimica et Biophysica Acta - General Subjects   1810 ( 3 )   251 - 258   2011年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbagen.2010.10.002

  • Surface segregation of poly(2-methoxyethyl acrylate) in a mixture with poly(methyl methacrylate) 査読

    Toyoaki Hirata, Hisao Matsuno, Masaru Tanaka, Keiji Tanaka

    Physical Chemistry Chemical Physics   13 ( 11 )   4928 - 4934   2011年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1039/c0cp02101f

  • 2H-NMR and 13C-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials 査読

    Yuko Miwa, Hiroyuki Ishida, Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1911 - 1924   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X489682

  • Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films 査読

    Yasumitsu Uraki, Chinatsu Matsumoto, Takuro Hirai, Yutaka Tamai, Makiko Enoki, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Journal of Wood Chemistry and Technology   30 ( 4 )   348 - 359   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/02773811003746709

  • Journal of Biomaterials Science, Polymer Edition Preface 査読

    Masaru Tanaka, Akira Mochizuki, Hiromi Kitano

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1827 - 1829   2010年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X527256

  • Hydration structure of poly(2-methoxyethyl acrylate) Comparison with a 2-methoxyethyl acetate model monomer 査読

    Shigeaki Morita, Masaru Tanaka, Kuniyuki Kitagawa, Yukihiro Ozaki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1925 - 1935   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X494613

  • Effect of honeycomb-patterned surface topography on the function of mesenteric adipocytes 査読

    Takashige Sato, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Kyoko Shimizu, Yasuyuki Igarashi, Masatsugu Shimomura, Jin Ichi Inokuchi

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1947 - 1956   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X500615

  • Clarification of the blood compatibility mechanism by controlling the water structure at the blood-poly(meth)acrylate interface 査読

    Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1849 - 1863   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X517220

  • 2H-NMR and 13C-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials 査読

    Yuko Miwa, Hiroyuki Ishida, Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1911 - 1924   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X489682

  • Thermal properties of freezing bound water restrained by polysaccharides 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Hyoe Hatakeyama

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1865 - 1875   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X486946

  • Study on the water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate) 査読

    Akira Mochizuki, Maki Kimura, Ayano Ina, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1895 - 1910   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X489321

  • Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films 査読

    Yasumitsu Uraki, Chinatsu Matsumoto, Takuro Hirai, Yutaka Tamai, Makiko Enoki, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Journal of Wood Chemistry and Technology   30 ( 4 )   348 - 359   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/02773811003746709

  • Journal of Biomaterials Science, Polymer Edition Preface 査読

    Masaru Tanaka, Akira Mochizuki, Hiromi Kitano

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1827 - 1829   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X527256

  • Hydration structure of poly(2-methoxyethyl acrylate) Comparison with a 2-methoxyethyl acetate model monomer 査読

    Shigeaki Morita, Masaru Tanaka, Kuniyuki Kitagawa, Yukihiro Ozaki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1925 - 1935   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X494613

  • Effect of honeycomb-patterned surface topography on the function of mesenteric adipocytes 査読

    Takashige Sato, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Kyoko Shimizu, Yasuyuki Igarashi, Masatsugu Shimomura, Jin Ichi Inokuchi

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1947 - 1956   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X500615

  • Clarification of the blood compatibility mechanism by controlling the water structure at the blood-poly(meth)acrylate interface 査読

    Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1849 - 1863   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X517220

  • 2H-NMR and 13C-NMR study of the hydration behavior of poly(2-methoxyethyl acrylate), poly(2-hydroxyethyl methacrylate) and poly(tetrahydrofurfuryl acrylate) in relation to their blood compatibility as biomaterials 査読

    Yuko Miwa, Hiroyuki Ishida, Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1911 - 1924   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X489682

  • Thermal properties of freezing bound water restrained by polysaccharides 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Hyoe Hatakeyama

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1865 - 1875   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X486946

  • Study on the water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate) 査読

    Akira Mochizuki, Maki Kimura, Ayano Ina, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1895 - 1910   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X489321

  • Mechanical effect of acetic acid lignin adsorption on honeycomb-patterned cellulosic films 査読

    Yasumitsu Uraki, Chinatsu Matsumoto, Takuro Hirai, Yutaka Tamai, Makiko Enoki, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Journal of Wood Chemistry and Technology   30 ( 4 )   348 - 359   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/02773811003746709

  • Journal of Biomaterials Science, Polymer Edition Preface 査読

    Masaru Tanaka, Akira Mochizuki, Hiromi Kitano

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1827 - 1829   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X527256

  • Hydration structure of poly(2-methoxyethyl acrylate) Comparison with a 2-methoxyethyl acetate model monomer 査読

    Shigeaki Morita, Masaru Tanaka, Kuniyuki Kitagawa, Yukihiro Ozaki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1925 - 1935   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X494613

  • Effect of honeycomb-patterned surface topography on the function of mesenteric adipocytes 査読

    Takashige Sato, Masaru Tanaka, Sadaaki Yamamoto, Emiko Ito, Kyoko Shimizu, Yasuyuki Igarashi, Masatsugu Shimomura, Jin Ichi Inokuchi

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1947 - 1956   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X500615

  • Clarification of the blood compatibility mechanism by controlling the water structure at the blood-poly(meth)acrylate interface 査読

    Masaru Tanaka, Akira Mochizuki

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1849 - 1863   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X517220

  • Study on the water structure and blood compatibility of poly(acryloylmorpholine-r-butyl methacrylate) 査読

    Akira Mochizuki, Maki Kimura, Ayano Ina, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1895 - 1910   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X489321

  • Thermal properties of freezing bound water restrained by polysaccharides 査読

    Tatsuko Hatakeyama, Masaru Tanaka, Hyoe Hatakeyama

    Journal of Biomaterials Science, Polymer Edition   21 ( 14 )   1865 - 1875   2010年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/092050610X486946

  • Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization 査読

    Hiroshi Ishihata, Masaru Tanaka, Nagayoshi Iwama, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    Journal of Biomechanical Science and Engineering   5 ( 3 )   252 - 261   2010年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1299/jbse.5.252

  • Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization 査読

    Hiroshi Ishihata, Masaru Tanaka, Nagayoshi Iwama, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    Journal of Biomechanical Science and Engineering   5 ( 3 )   252 - 261   2010年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1299/jbse.5.252

  • Proliferation of periodontal ligament cells on biodegradable honeycomb film scaffold with unified micropore organization 査読 国際誌

    Hiroshi Ishihata, Masaru Tanaka, Nagayoshi Iwama, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    Journal of Biomechanical Science and Engineering   5 ( 3 )   252 - 261   2010年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1299/jbse.5.252

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    T. Hatakeyama, M. Tanaka, H. Hatakeyama

    Acta Biomaterialia   6 ( 6 )   2077 - 2082   2010年6月

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    DOI: 10.1016/j.actbio.2009.12.018

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    T. Hatakeyama, M. Tanaka, H. Hatakeyama

    ACTA BIOMATERIALIA   6 ( 6 )   2077 - 2082   2010年6月

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    DOI: 10.1016/j.actbio.2009.12.018

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    Acta Biomaterialia   6 ( 6 )   2077 - 2082   2010年1月

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    DOI: 10.1016/j.actbio.2009.12.018

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    T. Hatakeyama, Masaru Tanaka, H. Hatakeyama

    Acta Biomaterialia   6 ( 6 )   2077 - 2082   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.actbio.2009.12.018

  • Fabrication of novel biocompatible surfaces by two-photon absorption technique using femtosecond laser 査読

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    Molecular Crystals and Liquid Crystals   505 ( 1 )   457 - 468   2009年12月

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    DOI: 10.1080/15421400902950121

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    Molecular Crystals and Liquid Crystals   505 ( 1 )   457 - 468   2009年12月

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    DOI: 10.1080/15421400902950121

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR 査読

    Polymer   50 ( 25 )   6091 - 6099   2009年11月

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    DOI: 10.1016/j.polymer.2009.10.037

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    POLYMER   50 ( 25 )   6091 - 6099   2009年11月

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    DOI: 10.1016/j.polymer.2009.10.037

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR 査読

    polymer   50 ( 25 )   6091 - 6099   2009年11月

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    DOI: 10.1016/j.polymer.2009.10.037

  • Network structures and dynamics of dry and swollen poly(acrylate)s. Characterization of high- and low-frequency motions as revealed by suppressed or recovered intensities (SRI) analysis of 13C NMR 査読

    Polymer   50 ( 25 )   6091 - 6099   2009年11月

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    DOI: 10.1016/j.polymer.2009.10.037

  • Control of cell fate using self-organized honeycomb-patterned films 査読

    Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2   2009年7月

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  • Control of human periodontal ligament cells proliferation on honeycomb-patterned films for regenerative periodontal therapy 査読

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    European Cells and Materials   18 ( SUPPL. 2 )   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Control of cell fate using self-organized honeycomb-patterned films 査読

    Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

    Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices   390 - 393   2009年7月

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

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    Nagayoshi Iwama, Masaru Tanaka, Hiroshi Ishihata, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   67   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Control of cell fate using self-organized honeycomb-patterned films 査読

    Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   2   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films 査読 国際誌

    Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    Biodevices   390 - 393   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Control of human periodontal ligament cells proliferation on honeycomb-patterned films for regenerative periodontal therapy 査読

    Nagayoshi Iwama, Masaru Tanaka, Hiroshi Ishihata, Masahiro Ara, Mitsuru Shimonishi, Masaru Nagamine, Noriaki Murakami, Sousuke Kanaya, Eiji Nemoto, Hidetoshi Shimauchi, Masatsugu Shimomura

    European Cells and Materials   18 ( SUPPL. 2 )   67   2009年7月

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  • Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned films 査読

    Masaru Tanaka, Masafumi Takebayashi, Masatsugu Shimomura

    Macromolecular Symposia   279 ( 1 )   175 - 182   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/masy.200950527

  • Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned films 査読

    Masaru Tanaka, Masafumi Takebayashi, Masatsugu Shimomura

    Macromolecular Symposia   279 ( 1 )   175 - 182   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/masy.200950527

  • Fabrication of ordered arrays of biodegradable polymer pincushions using self-organized honeycomb-patterned films 査読

    Masaru Tanaka, Masafumi Takebayashi, Masatsugu Shimomura

    Macromolecular Symposia   279 ( 1 )   175 - 182   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/masy.200950527

  • Water structure and blood compatibility of poly(tetrahydrofurfuryl acrylate) 査読

    Akira Mochizuki, Tatsuko Hatakeyama, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   20 ( 5-6 )   591 - 603   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/156856209X426411

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    Journal of Biomaterials Science, Polymer Edition   20 ( 5-6 )   591 - 603   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/156856209X426411

  • Water structure and blood compatibility of poly(tetrahydrofurfuryl acrylate) 査読

    Akira Mochizuki, Tatsuko Hatakeyama, Yuka Tomono, Masaru Tanaka

    Journal of Biomaterials Science, Polymer Edition   20 ( 5-6 )   591 - 603   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1163/156856209X426411

  • Anti-biofouling properties of polymers with a carboxybetaine moiety 査読

    Sulumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Geminei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

    Macromolecular Bioscience   9 ( 1 )   63 - 70   2009年1月

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    DOI: 10.1002/mabi.200800150

  • Anti-Biofouling Properties of Polymers with a Carboxybetaine Moiety 査読

    Susumu Tada, Chika Inaba, Kazuya Mizukami, Shigeto Fujishita, Makoto Gemmei-Ide, Hiromi Kitano, Akira Mochizuki, Masaru Tanaka, Takayuki Matsunaga

    MACROMOLECULAR BIOSCIENCE   9 ( 1 )   63 - 70   2009年1月

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    DOI: 10.1002/mabi.200800150

  • Tuning of cell proliferation on tough gels by critical charge effect 査読

    Mei Chen Yong, Jian Ping Gong, Masaru Tanaka, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Journal of Biomedical Materials Research - Part A   88 ( 1 )   74 - 83   2009年1月

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    DOI: 10.1002/jbm.a.31869

  • Comparative study on water structures in PolyHEMA and PolyMEA by XRD-DSC simultaneous measurement 査読

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    Journal of Applied Polymer Science   111 ( 1 )   476 - 481   2009年1月

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    DOI: 10.1002/app.29127

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    Macromolecular Bioscience   9 ( 1 )   63 - 70   2009年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.200800150

  • Tuning of cell proliferation on tough gels by critical charge effect 査読

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    Journal of Biomedical Materials Research - Part A   88 ( 1 )   74 - 83   2009年1月

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    DOI: 10.1002/jbm.a.31869

  • Comparative study on water structures in PolyHEMA and PolyMEA by XRD-DSC simultaneous measurement 査読

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    Journal of Applied Polymer Science   111 ( 1 )   476 - 481   2009年1月

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    DOI: 10.1002/app.29127

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    Macromolecular Bioscience   9 ( 1 )   63 - 70   2009年1月

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    DOI: 10.1002/mabi.200800150

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    Journal of Biomedical Materials Research - Part A   88 ( 1 )   74 - 83   2009年1月

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    DOI: 10.1002/jbm.a.31869

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    Journal of Applied Polymer Science   111 ( 1 )   476 - 481   2009年1月

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    DOI: 10.1002/app.29127

  • Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

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    Molecular Crystals and Liquid Crystals   505 ( 1 )   219/[457] - 230/[468]   2009年

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    DOI: 10.1080/15421400902950121

  • Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model 査読

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    Journal of Biomedical Materials Research - Part B Applied Biomaterials   86 ( 2 )   353 - 359   2008年8月

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    DOI: 10.1002/jbm.b.31026

  • Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model 査読

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    Journal of Biomedical Materials Research - Part B Applied Biomaterials   86 ( 2 )   353 - 359   2008年8月

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    DOI: 10.1002/jbm.b.31026

  • Prevention of postoperative adhesions by a novel honeycomb-patterned poly(lactide) film in a rat experimental model 査読

    Yukako Fukuhira, Masaya Ito, Hiroaki Kaneko, Yoshihiko Sumi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   86 ( 2 )   353 - 359   2008年8月

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    DOI: 10.1002/jbm.b.31026

  • Control of neural stem cell differentiation on honeycomb films 査読

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   536 - 540   2008年2月

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    DOI: 10.1016/j.colsurfa.2007.05.079

  • Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film 査読

    Masaru Tanaka, Keiko Yoshizawa, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   515 - 519   2008年2月

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    DOI: 10.1016/j.colsurfa.2007.05.081

  • Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films 査読

    Shusaku Tsukiyama, Michiaki Matsushita, Masaru Tanaka, Hitoshi Tamura, Satoru Todo, Sadaaki Yamamoto, Masatsugu Shimomura

    Japanese Journal of Applied Physics   47 ( 2 PART 2 )   1429 - 1434   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.47.1429

  • Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes 査読

    Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   530 - 535   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.04.128

  • Effect of honeycomb-patterned structure on chondrocyte behavior in vitro 査読

    Yukako Fukuhira, Hiroaki Kaneko, Mika Yamaga, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   520 - 525   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.047

  • Control of neural stem cell differentiation on honeycomb films 査読

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   536 - 540   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.079

  • Formation of hydroxyapatite on a self-organized 3D honeycomb-patterned biodegradable polymer film 査読

    Masaru Tanaka, Keiko Yoshizawa, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   515 - 519   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.081

  • Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films 査読

    Shusaku Tsukiyama, Michiaki Matsushita, Masaru Tanaka, Hitoshi Tamura, Satoru Todo, Sadaaki Yamamoto, Masatsugu Shimomura

    Japanese Journal of Applied Physics   47 ( 2 PART 2 )   1429 - 1434   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.47.1429

  • Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes 査読

    Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   530 - 535   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.04.128

  • Effect of honeycomb-patterned structure on chondrocyte behavior in vitro 査読

    Yukako Fukuhira, Hiroaki Kaneko, Mika Yamaga, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   520 - 525   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.047

  • Control of neural stem cell differentiation on honeycomb films 査読

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   536 - 540   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.079

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    Masaru Tanaka, Keiko Yoshizawa, Akinori Tsuruma, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   515 - 519   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.081

  • Enhanced cell survival and yield of rat small hepatocytes by honeycomb-patterned films 査読

    Shusaku Tsukiyama, Michiaki Matsushita, Masaru Tanaka, Hitoshi Tamura, Satoru Todo, Sadaaki Yamamoto, Masatsugu Shimomura

    Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes   47 ( 2 PART 2 )   1429 - 1434   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.47.1429

  • Effect of pore size of honeycomb films on the morphology, adhesion and cytoskeletal organization of cardiac myocytes 査読

    Keiko Arai, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   530 - 535   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.04.128

  • Effect of honeycomb-patterned structure on chondrocyte behavior in vitro 査読

    Yukako Fukuhira, Hiroaki Kaneko, Mika Yamaga, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   313-314   520 - 525   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2007.05.047

  • Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film 査読

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Applied Spectroscopy   62 ( 1 )   46 - 50   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370208783412555

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy 査読

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    MACROMOLECULAR BIOSCIENCE   8 ( 1 )   77 - 85   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.200700082

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy 査読

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    Macromolecular Bioscience   8 ( 1 )   77 - 85   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.200700082

  • Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film 査読

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Applied Spectroscopy   62 ( 1 )   46 - 50   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370208783412555

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy 査読

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    Macromolecular Bioscience   8 ( 1 )   77 - 85   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.200700082

  • Multivariate curve resolution analysis on the multi-component water sorption process into a poly(2-methoxyethyl acrylate) film 査読

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Applied Spectroscopy   62 ( 1 )   46 - 50   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370208783412555

  • Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy 査読

    Hiromi Kitano, Kyoko Nagaoka, Susumu Tada, Makoto Gemmei-Ide, Masaru Tanaka

    Macromolecular Bioscience   8 ( 1 )   77 - 85   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/mabi.200700082

  • Control of cell proliferation and differentiation using self-organized honeycomb-patterned films

    Masaru Tanaka, Akinori Tsuruma, Yuka Morita, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   4   2254   2008年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Microporous "honeycomb" films support enhanced bone formation in vitro

    Mark Birch, Masaru Tanaka, George Kirmizidis, Ito Emiko, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   2   836   2008年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Control of cell proliferation and differentiation using self-organized honeycomb-patterned films

    Masaru Tanaka, Akinori Tsuruma, Yuka Morita, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   4   2254   2008年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Microporous "honeycomb" films support enhanced bone formation in vitro

    Mark Birch, Masaru Tanaka, George Kirmizidis, Ito Emiko, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   2   836   2008年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Control of cell proliferation and differentiation using self-organized honeycomb-patterned films

    Masaru Tanaka, Akinori Tsuruma, Yuka Morita, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   4   2254   2008年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Microporous "honeycomb" films support enhanced bone formation in vitro

    Mark Birch, Masaru Tanaka, George Kirmizidis, Ito Emiko, Sadaaki Yamamoto, Masatsugu Shimomura

    8th World Biomaterials Congress 2008, WBC 2008 8th World Biomaterials Congress 2008   2   836   2008年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Cold crystallization of poly(ethylene glycol)-water systems 査読

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    Thermochimica Acta   465 ( 1-2 )   59 - 66   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2007.09.005

  • Direct observation of interaction between proteins and blood-compatible polymer surfaces 査読

    Tomohiro Hayashi, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura, Masahiko Hara

    BIOINTERPHASES   2 ( 4 )   119 - 125   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1116/1.2794712

  • Cold crystallization of poly(ethylene glycol)-water systems 査読

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    THERMOCHIMICA ACTA   465 ( 1-2 )   59 - 66   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2007.09.005

  • Cold crystallization of poly(ethylene glycol)-water systems 査読

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    Thermochimica Acta   465 ( 1-2 )   59 - 66   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2007.09.005

  • Cold crystallization of poly(ethylene glycol)-water systems 査読

    Tatsuko Hatakeyma, Hazuki Kasuga, Masaru Tanaka, Hyoe Hatakeyama

    Thermochimica Acta   465 ( 1-2 )   59 - 66   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.tca.2007.09.005

  • ハニカム構造フィルム上におけるフィブロネクチンの吸着構造と細胞接着

    山本貞明, 田中賢, 角南寛, 新井景子, 高山あい子, 山下滋京子, 森田有香, 下村政嗣

    表面科学講演大会講演要旨集   27th   223   2007年11月

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    記述言語:日本語  

    DOI: 10.14886/sssj.27.0.223.0

  • 原子間力顕微鏡によるハニカム構造フィルム上での血管内皮細胞の初期接着形態観察

    山本貞明, 水谷武臣, 田中賢, 伊藤絵美子, ENIWUMIDE J. O, 森田由香, 角南寛, 居城邦治, 川端和重, 下村政嗣

    表面科学講演大会講演要旨集   27th   152   2007年11月

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    記述言語:日本語  

    DOI: 10.14886/sssj.27.0.152.0

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra 査読

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    Applied Spectroscopy   61 ( 8 )   867 - 872   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370207781540051

  • 血管内皮細胞の初期伸展に及ぼすハニカムフィルム細孔径の影響 査読

    山本貞明, 田中賢, 伊藤絵美子, 森田有香, 角南寛, 居城邦治, 下村政嗣

    表面科学   28 ( 8 )   433 - 439   2007年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    The mechanism that cells use to recognize micro-patterned topographies was clarified. First, 3D double-layer poly (ε-caprolactone) scaffolds equipped with honeycomb-patterned micro-pores ("honeycomb films") were prepared. Then, porcine aortic endothelial cells (PAECs) were cultured on these scaffolds for 1-6 h in serum-free medium. Finally, their initial spreading process was investigated by using AFM and confocal laser scanning microscopy. The attachment and spreading of PAECs on honeycomb films having either 6-or 16-μm pore diameters resulted in voids within the cell cytoplasm, which correspond with the size and location of the honeycomb micropores. The number of cells with this unique morphology decreased with increasing culture time. This dependence of morphology on film pore size and culture time suggests a spreading process of PAECs in which the cells spread trying to sense suitable sites to adhere. Using thick filopodia, the cells spread along the rim of the film and produced pores by close contact between two spreading filopodia. Evidently, these pores became filled in during culture, presumably as the cells began to reorganize their cytoplasma.

    DOI: 10.1380/jsssj.28.433

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy 査読

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumot

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS   46 ( 8B )   5552 - 5555   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.46.5552

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra 査読

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    APPLIED SPECTROSCOPY   61 ( 8 )   867 - 872   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370207781540051

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy 査読

    Takaharu Okajima, Masara Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers   46 ( 8 B )   5552 - 5555   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.46.5552

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra 査読

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    Applied Spectroscopy   61 ( 8 )   867 - 872   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370207781540051

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy 査読

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers   46 ( 8 B )   5552 - 5555   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.46.5552

  • Phase angle description of perturbation correlation analysis and its application to time-resolved infrared spectra 査読

    Shigeaki Morita, Masaru Tanaka, Isao Noda, Yukihiro Ozaki

    Applied Spectroscopy   61 ( 8 )   867 - 872   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1366/000370207781540051

  • Stress relaxation measurement of fibroblast cells with atomic force microscopy 査読

    Takaharu Okajima, Masaru Tanaka, Shusaku Tsukiyama, Tsubasa Kadowaki, Sadaaki Yamamoto, Masatsugu Shimomura, Hiroshi Tokumoto

    Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes   46 ( 8 B )   5552 - 5555   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1143/JJAP.46.5552

  • Effect of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells 査読

    S. Yamamoto, Masaru Tanaka, H. Sunami, E. Ito, S. Yamashita, Y. Morita, M. Shimomura

    Langmuir   23 ( 15 )   8114 - 8120   2007年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la7003326

  • Effect of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells 査読

    S. Yamamoto, M. Tanaka, H. Sunami, E. Ito, S. Yamashita, Y. Morita, M. Shimomura

    LANGMUIR   23 ( 15 )   8114 - 8120   2007年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/1a7003326

  • Effect of honeycomb-patterned surface topography on the adhesion and signal transduction of porcine aortic endothelial cells 査読

    S. Yamamoto, Masaru Tanaka, H. Sunami, E. Ito, S. Yamashita, Y. Morita, M. Shimomura

    Langmuir   23 ( 15 )   8114 - 8120   2007年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la7003326

  • Relationship between blood compatibility and water structure - Comparative study between 2-methoxyethylacrylate- and 2-methoxyethylmethacrylate-based random copolymers 査読

    Etsuko Hirota, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   81 ( 3 )   710 - 719   2007年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.31113

  • Relationship between blood compatibility and water structure - Comparative study between 2-methoxyethylacrylate- and 2-methoxyethylmethacrylate-based random copolymers 査読

    Etsuko Hirota, Masaru Tanaka, Akira Mochizuki

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   81A ( 3 )   710 - 719   2007年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.31113

  • Relationship between blood compatibility and water structure - Comparative study between 2-methoxyethylacrylate- and 2-methoxyethylmethacrylate-based random copolymers 査読

    Etsuko Hirota, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   81 ( 3 )   710 - 719   2007年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.31113

  • Honeycomb-like architecture produced by living bacteria, Gluconacetobacter xylinus 査読

    Yasumitsu Uraki, Junji Nemoto, Hiroyuki Otsuka, Yutaka Tamai, Junji Sugiyama, Takao Kishimoto, Makoto Ubukata, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Carbohydrate Polymers   69 ( 1 )   1 - 6   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.carbpol.2006.08.021

  • Honeycomb-like architecture produced by living bacteria, Gluconacetobacter xylinus 査読

    Yasumitsu Uraki, Junji Nemoto, Hiroyuki Otsuka, Yutaka Tamai, Junji Sugiyama, Takao Kishimoto, Makoto Ubukata, Hiroshi Yabu, Masaru Tanaka, Masatsugu Shimomura

    Carbohydrate Polymers   69 ( 1 )   1 - 6   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.carbpol.2006.08.021

  • Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds 査読

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Biomaterials   28 ( 10 )   1752 - 1760   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biomaterials.2006.12.005

  • Small-diameter porous poly (ε-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cells 査読

    13 ( 4 )   789 - 798   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Autologous keratinocyte grafts provide clinical benefit by rapidly covering wounded areas, but they are fragile. We therefore developed hiocompatihle hexagonal-packed porous films with uniform, circular pore sizes to support human keratinocytes and fibroblasts. Cells were cultured on these porous poly (ε-calprolactone) films with pore sizes ranging from novel ultra-small 3 μm to 20 μm. These were compared with flat (pore-less) films. Cell growth rates, adhesion, migration, and ultrastructural morphology were examined. Human keratinocytes and fibroblasts attached to all films. Furthermore, small-pore (3-5 μm) films showed the highest levels of cell adhesion and survival and prevented migration into the pores and opposing film surface. Keratinocyte migration over small-pore film surface was inhibited. Keratinocytes optimally attached to 3-μm-pore films due to a combination of greater pore numbers (porosity), a greater circumference of the pore edge per unit surface area, and greater frequency of flat surface areas for attachment, allowing better cell-substrate and cell-cell attachment and growth. The 3-μm pore size allowed cell-cell communication, together with diffusion of soluble nutrients and factors from the culture medium or wound substrate. These characteristics are considered important in developing grafts for use in the treatment of human skin wounds.

    DOI: 10.1089/ten.2006.0321

  • Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds 査読

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Kazunori Yasuda, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    Biomaterials   28 ( 10 )   1752 - 1760   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biomaterials.2006.12.005

  • Small-diameter porous poly (ε-caprolactone) films enhance adhesion and growth of human cultured epidermal keratinocyte and dermal fibroblast cells 査読

    13 ( 4 )   789 - 798   2007年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Autologous keratinocyte grafts provide clinical benefit by rapidly covering wounded areas, but they are fragile. We therefore developed hiocompatihle hexagonal-packed porous films with uniform, circular pore sizes to support human keratinocytes and fibroblasts. Cells were cultured on these porous poly (ε-calprolactone) films with pore sizes ranging from novel ultra-small 3 μm to 20 μm. These were compared with flat (pore-less) films. Cell growth rates, adhesion, migration, and ultrastructural morphology were examined. Human keratinocytes and fibroblasts attached to all films. Furthermore, small-pore (3-5 μm) films showed the highest levels of cell adhesion and survival and prevented migration into the pores and opposing film surface. Keratinocyte migration over small-pore film surface was inhibited. Keratinocytes optimally attached to 3-μm-pore films due to a combination of greater pore numbers (porosity), a greater circumference of the pore edge per unit surface area, and greater frequency of flat surface areas for attachment, allowing better cell-substrate and cell-cell attachment and growth. The 3-μm pore size allowed cell-cell communication, together with diffusion of soluble nutrients and factors from the culture medium or wound substrate. These characteristics are considered important in developing grafts for use in the treatment of human skin wounds.

    DOI: 10.1089/ten.2006.0321

  • Effect of pore size of self-organized honeycomb-patterned polymer films on spreading, focal adhesion, proliferation, and function of endothelial cells 査読

    Masaru Tanaka, Aiko Takayama, Emiko Ito, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of Nanoscience and Nanotechnology   7 ( 3 )   763 - 772   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1166/jnn.2007.514

  • Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film 査読

    Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Langmuir   23 ( 7 )   3750 - 3761   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la0625998

  • Effect of pore size of self-organized honeycomb-patterned polymer films on spreading, focal adhesion, proliferation, and function of endothelial cells 査読

    Masaru Tanaka, Aiko Takayama, Emiko Ito, Hiroshi Sunami, Sadaaki Yamamoto, Masatsugu Shimomura

    Journal of nanoscience and nanotechnology   7 ( 3 )   763 - 772   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1166/jnn.2007.514

  • Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film 査読

    Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    Langmuir   23 ( 7 )   3750 - 3761   2007年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1021/la0625998

  • Stress relaxation of HepG2 cells measured by atomic force microscopy 査読

    T. Okajima, Masaru Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura, H. Tokumoto

    Nanotechnology   18 ( 8 )   2007年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1088/0957-4484/18/8/084010

  • 18aTC-8 原子間力顕微鏡による生細胞の力学緩和測定(生物物理,領域12,ソフトマター物理,化学物理,生物物理)

    岡嶋 孝治, 田中 賢, 築山 周作, 門脇 翼, 山本 貞明, 下村 政嗣, 徳本 洋志

    日本物理学会講演概要集   62 ( 1 )   325 - 325   2007年2月

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    記述言語:日本語  

  • Effect of Surface Electrostatic Property on Chondrogenic Differentiation of Human Mesenchymal Stem Cells

    Li Guo, Yu Jiang Fan, Naoki Kawazoe, Guo Ping Chen, M. Tanaka, Tetsuya Tateishi, Xing Dong Zhang

    Key Engineering Materials   330-332   1189 - 1192   2007年2月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.4028/www.scientific.net/kem.330-332.1189

  • Stress relaxation of HepG2 cells measured by atomic force microscopy 査読

    T. Okajima, M. Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura, H. Tokumoto

    Nanotechnology   18 ( 8 )   2007年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1088/0957-4484/18/8/084010

  • Suppression of neural stem cell differentiation by Honeycomb-patterned films 査読

    Akinori Tsuruma, Masaru Tanaka, Sada Aki Yamamoto, Masatsugu Shimomura

    10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 IFMBE Proceedings   14 ( 1 )   3558 - 3561   2007年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Suppression of neural stem cell differentiation by Honeycomb-patterned films 査読

    Akinori Tsuruma, Masaru Tanaka, Sada Aki Yamamoto, Masatsugu Shimomura

    10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 IFMBE Proceedings   14 ( 1 )   3558 - 3561   2007年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Direct observation of biocompatibility of PMEA(poly(2-methoxyethyl acrylate)) using Atomic Force Microscop 査読

    Tomohiro Hayashi, Masaru Tanaka

    Biointerphases   2   119   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • The influence of pore size of a honeycomb film on early spreading process of endtherial cells 査読

    Sadaaki Yamamoto, Masaru Tanaka

    J. Surf. Sci. Soc. Jap   28 ( 8 )   433   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Direct observation of biocompatibility of PMEA(poly(2-methoxyethyl acrylate)) using Atomic Force Microscop 査読

    Tomohiro Hayashi, Masaru Tanaka

    Biointerphases   2   119   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • The influence of pore size of a honeycomb film on early spreading process of endtherial cells 査読

    Sadaaki Yamamoto, Masaru Tanaka

    J. Surf. Sci. Soc. Jap   28 ( 8 )   433   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Study on structure of water in membranes of PMEA and PHEMA by 2H-NMR

    Hiroyuki Ishida, Yuko Miwa, Akira Mochizuki, Masaru Tanaka

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4375 - 4376   2006年12月

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Study on structure of water in PMEA and PHEMA and there copolymers by 2H solid-state NMR

    Yuko Miwa, Hiroyuki Ishida, Akira Mochizuki, Masaru Tanaka

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2006年10月

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Relationship between adsorbed fibronectin and cell adhesion on a honeycomb-patterned film 査読

    Sadaaki Yamamoto, Masaru Tanaka, Hiroshi Sunami, Keiko Arai, Aiko Takayama, Shigeko Yamashita, Yuka Morita, Masatsugu Shimomura

    Surface Science   600 ( 18 )   3785 - 3791   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.susc.2006.01.085

  • Relationship between adsorbed fibronectin and cell adhesion on a honeycomb-patterned film 査読

    Sadaaki Yamamoto, Masaru Tanaka, Hiroshi Sunami, Keiko Arai, Aiko Takayama, Shigeko Yamashita, Yuka Morita, Masatsugu Shimomura

    Surface Science   600 ( 18 )   3785 - 3791   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.susc.2006.01.085

  • Control of hepatocyte adhesion and function on self-organized honeycomb-patterned polymer film 査読

    Masaru Tanaka, Kazutaka Nishikawa, Hisashi Okubo, Hirofumi Kamachi, Tomoaki Kawai, Michiaki Matsushita, Satoru Todo, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   464 - 469   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2005.11.098

  • Topographical control of neurite extension on stripe-patterned polymer films 査読

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Nobuyuki Fukushima, Hiroshi Yabu, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   470 - 474   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2005.11.100

  • Effect of honeycomb film on protein adsorption, cell adhesion and proliferation 査読

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   548 - 551   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2005.11.041

  • Control of hepatocyte adhesion and function on self-organized honeycomb-patterned polymer film 査読

    Masaru Tanaka, Kazutaka Nishikawa, Hisashi Okubo, Hirofumi Kamachi, Tomoaki Kawai, Michiaki Matsushita, Satoru Todo, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   464 - 469   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2005.11.098

  • Topographical control of neurite extension on stripe-patterned polymer films 査読

    Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Nobuyuki Fukushima, Hiroshi Yabu, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   470 - 474   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2005.11.100

  • Effect of honeycomb film on protein adsorption, cell adhesion and proliferation 査読

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    Colloids and Surfaces A: Physicochemical and Engineering Aspects   284-285   548 - 551   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.colsurfa.2005.11.041

  • Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine 査読

    Yukako Fukuhira, Eiichi Kitazono, Takami Hayashi, Hiroaki Kaneko, Masaru Tanaka, Masatsugu Shimomura, Yoshihiko Sumi

    Biomaterials   27 ( 9 )   1797 - 1802   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biomaterials.2005.10.019

  • Study on blood compatibility with poly(2-methoxyethylacrylate)-relationship between surface structure., water structure, and platelet compatibility in 2-methoxyethylacrylate/2hydroxyethylmethacrylate diblock copolymer 査読

    E Hirota, K Ute, M Uehara, T Kitayama, M Tanaka, A Mochizuki

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   76A ( 3 )   540 - 550   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.30563

  • Study on blood compatibility with poly(2-methoxyethylacrylate) - Relationship between surface structure, water structure, and platelet compatibility in 2-methoxyethylacrylate/2-hydroxyethylmethacrylate diblock copolymer 査読

    Etsuko Hirota, Koichi Ute, Mitsunari Uehara, Tatsuki Kitayama, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   76 ( 3 )   540 - 550   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.30563

  • Study on blood compatibility with poly(2-methoxyethylacrylate) - Relationship between surface structure, water structure, and platelet compatibility in 2-methoxyethylacrylate/2-hydroxyethylmethacrylate diblock copolymer 査読

    Etsuko Hirota, Koichi Ute, Mitsunari Uehara, Tatsuki Kitayama, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   76 ( 3 )   540 - 550   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.30563

  • Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine 査読

    Yukako Fukuhira, Eiichi Kitazono, Takami Hayashi, Hiroaki Kaneko, Masaru Tanaka, Masatsugu Shimomura, Yoshihiko Sumi

    Biomaterials   27 ( 9 )   1797 - 1802   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.biomaterials.2005.10.019

  • Study on blood compatibility with poly(2-methoxyethylacrylate) - Relationship between surface structure, water structure, and platelet compatibility in 2-methoxyethylacrylate/2-hydroxyethylmethacrylate diblock copolymer 査読

    Etsuko Hirota, Koichi Ute, Mitsunari Uehara, Tatsuki Kitayama, Masaru Tanaka, Akira Mochizuki

    Journal of Biomedical Materials Research - Part A   76 ( 3 )   540 - 550   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jbm.a.30563

  • Adhesion and signal transduction of endothelial cells on a honeycomb films pre-coated by fibronectin

    Sadaaki Yamamot, Masaru Tanaka, Hiroshi Sunami, Yuka Mortta, Emio Ito, Keiko Arai, Shigeko Yamashita, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5493 - 5494   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Surface properties of endothelial cells cultured on hydrogels

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Yasuda Kazunori, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4860   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [24] ATR-IR studied of protein adsorption onto biocompatible polymer

    Shoji Deguchi, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4379 - 4380   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [23] multivariate analysis of time-resolved IR spectra upon water sorption into PMEA film

    Akiko Tanabe, Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4377 - 4378   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Relationship between adsorbed fibronectin and FAK activation on a honeycomb-patterned film 査読

    Masaru Tanaka

    J. Surf. Sci. Soc. Jap   27 ( 10 )   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Measurement of ice crystal formation in biocompatible polymer by XRD-DSC

    Akira Kishi, Masaru Tanaka, Akira Mochizuki

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   2139   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Growth inhibition of cancer cells on honeycomb films

    Chiho Asahi, Masaru Tanaka, Jun Ichi Hamada, Yoshihide Toyokawa, Emiko Ito, Sadaaki Yamamoto, Masatsugu Shimomura

    55th SPSJ Annual Meeting Polymer Preprints, Japan - 55th SPSJ Annual Meeting   55   1918   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Control of cytoskeletone structure by using 3D microporus film

    Hiroshi Sunami, Emiko Ito, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   5422 - 5423   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Biomedical application of patterned polymer films prepared by self-organization 査読

    Masaru Tanaka, Masatsugu Shimomura

    J. Surf. Sci. Soc. Jap   27   170   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Time-resolved IR observations of molecular sorption to a polymer film from a solution

    Shigeaki Morita, Masaru Tanaka, Yukihiro Ozaki

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Symposium on Macromolecules   55   4278 - 4279   2006年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

  • Surface properties of endothelial cells cultured on hydrogels

    Yong Mei Chen, Masaru Tanaka, Jian Ping Gong, Yasuda Kazunori, Sadaaki Yamamoto, Masatsugu Shimomura, Yoshihito Osada

    55th Society of Polymer Science Japan Symposium on Macromolecules 55th SPSJ Sym