Updated on 2024/07/28

Information

 

写真a

 
NAKAMURA KUNIYUKI
 
Organization
Kyushu University Hospital Department of Nephrology,Hypertension,and Strokology Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
メールアドレス
Profile
<Research project> Elucidation of repair mechanism for cerebrovascular diseases (ischemic stroke) by brain pericytes and extracellular matrix <Education> Clinical training for undergraduate students and Research guidance for graduate students <Clinical work> Acute phase treatment for stroke, outpatient treatment of patients with cerebrovascular diseases
External link

Degree

  • MD, PhD

Research History

  • 福岡歯科大学　2013.4~2015.3

Research Interests・Research Keywords

  • Research theme：Elucidation of repair mechanism for cerebrovascular diseases by pericytes and extracellular matrix

    Keyword：pericyte, extracellular matrix, blood-brain barrier, ischemic stroke

    Research period： 2018.4

Awards

  • Young Investigator Award

    2018.6  

  • Fellows Award for Research Excellence (FARE) 2018

    2017.11   National Institutes of Health  

  • Young bursary

    2007.5   The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function  

Papers

  • Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects. Reviewed International journal

    Masamitsu Takashima, Kuniyuki Nakamura, Takuya Kiyohara, Yoshinobu Wakisaka, Masaoki Hidaka, Hayato Takaki, Kei Yamanaka, Tomoya Shibahara, Masanori Wakisaka, Tetsuro Ago, Takanari Kitazono

    Communications biology   5 ( 1 )   653 - 653   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s42003-022-03605-4

  • Reciprocal Interaction Between Pericytes and Macrophage in Poststroke Tissue Repair and Functional Recovery. Reviewed International journal

    Tomoya Shibahara, Tetsuro Ago, Masaki Tachibana, Kuniyuki Nakamura, Kei Yamanaka, Junya Kuroda, Yoshinobu Wakisaka, Takanari Kitazono

    Stroke   51 ( 10 )   3095 - 3106   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/STROKEAHA.120.029827.

  • Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Reviewed International journal

    7 ( 2 )   2020.3

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    Language：English  

    DOI： 10.1523/ENEURO.0474-19.2020.

  • Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier. Reviewed International journal

    Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y.

    J Cell Biol.   218 ( 10 )   3506 - 3525   2019.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1083/jcb.201807178.

  • Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke. Reviewed International journal

    1630   98 - 108   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Central nervous system (CNS) pericytes have been recognized as an indispensable component of the neurovascular unit. The expression of platelet-derived growth factor receptor β (PDGFRβ) is markedly increased in CNS pericytes after brain ischemia. It has been elucidated that PDGFRβ, expressed in pericytes and pericyte-derived fibroblast-like cells, plays important roles in the maintenance of the blood-brain barrier (BBB) and in the repair process in infarct areas. The aim of this study was to uncover how the PDGFRβ expression is regulated in pericytes after brain ischemia. We found that basic fibroblast growth factor (bFGF), but neither hypoxia at 1&#37; O2 nor acidification at pH 6.5, significantly upregulated the PDGFRβ expression in human cultured CNS pericytes. SU5402, an inhibitor of FGF receptor (FGFR), and inhibitors of its downstream effectors Akt and Erk abolished the bFGF-induced upregulation of PDGFRβ. On the other hand, acidification significantly upregulated the expression of bFGF, while hypoxia upregulated the expression of FGFR1 in the pericytes. The expression of bFGF and FGFR1 was markedly induced in the ischemic hemisphere after ischemic insult in a middle cerebral artery occlusion stroke model. Immunofluorescent double labeling demonstrated that the expression of bFGF and FGFR1 was co-localized with PDGFRβ-positive cells in peri-infarct areas. Moreover, treatment with bFGF enhanced cell growth and the PDGF-BB-induced migratory activity of cultured pericytes, which were significantly suppressed by SU5402 or Sunitinib, an inhibitor of PDGFR. These data suggested that increased bFGF upregulates the expression of PDGFRβ and may enhance PDGFRβ-mediated pericyte functions after brain ischemia.

    DOI： 10.1016/j.brainres.2015.11.003

  • Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke. Reviewed International journal

    264   127 - 34   2015.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Fibrosis is concomitant with repair processes following injuries in the central nervous system (CNS). Pericytes are considered as an origin of fibrosis-forming cells in the CNS. Here, we examined whether platelet-derived growth factor receptor β (PDGFRβ), a well-known indispensable molecule for migration, proliferation, and survival of pericytes, was involved in the production of extracellular matrix proteins, fibronectin and collagen type I, which is crucial for fibrosis after ischemic stroke. Immunohistochemistry demonstrated induction of PDGFRβ expression in vascular cells of peri-infarct areas at 3-7days in a mouse stroke model. The PDGFRβ-expressing cells extended from peri-infarct areas toward the ischemic core after day 7 while expressing fibronectin and collagen type I in the infarct areas. In contrast, desmin and α-smooth muscle actin, markers of pericytes, were only expressed in vascular cells. In PDGFRβ heterozygous knockout mice, the expression of fibronectin and collagen type I was attenuated at both mRNA and protein levels with an enlargement of the infarct volume after ischemic stroke compared with that in wild-type littermates. In cultured brain pericytes, the expression of PDGF-B, PDGFRβ, fibronectin, and collagen type I, but not desmin, was significantly increased by serum depletion (SD). The SD-induced upregulation of fibronectin and collagen type I was suppressed by SU11652, an inhibitor of PDGFRβ, while PDGF-B further increased the SD-induced upregulation. In conclusion, the expression level of PDGFRβ may be a crucial determinant of fibrosis after ischemic stroke. Moreover, PDGFRβ signaling participates in the production of fibronectin and collagen type I after ischemic stroke.

    DOI： 10.1016/j.expneurol.2014.12.007

  • Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca2+ oscillation in central nervous system pericytes. Reviewed International journal

    Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T.

    Arterioscler Thromb Vasc Biol.   32 ( 11 )   2670 - 7   2012.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/ATVBAHA.112.254946

  • PDGF receptor β signaling in pericytes following ischemic brain injury. Reviewed International journal

    9 ( 1 )   1 - 9   2012.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Platelet derived growth factor (PDGF)-B plays a neuroprotective role in brain damages, including ischemic stroke. It has been suggested recently that PDGF receptor β (PDGFRβ) expressed in brain pericytes as well as in neurons and astrocytes may mediate the neuroprotective role of PDGF-B. The aims of this study were to elucidate the roles of PDGFRβ signaling in brain pericytes after ischemic stroke. In a rat middle cerebral artery occlusion (MCAO) model, PDGFRβ expression was induced specifically in the pericytes in peri-infarct areas and its level was gradually increased. PDGF-B induced marked phosphorylation of Akt in cultured brain pericytes. Consistently, PDGF-B was upregulated in endothelial cells in per-infarct areas and Akt was strongly phosphorylated in the PDGFRβ-expressing pericytes in periinfarct areas after MCAO. In the cultured pericytes, PDGF-B induced cell growth and anti-apoptotic responses through Akt. Furthermore, PDGF-B significantly increased the expression of nerve growth factor (NGF) and neurotrophin-3 (NT-3) through Akt in the pericytes. Thus, the PDGFRβ-Akt signaling in brain pericytes may play various important roles leading to neuroprotection after ischemic stroke.

  • Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes. Reviewed International journal

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M.

    Am J Physiol Heart Circ Physiol.   294 ( 4 )   H1700-7   2008.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajpheart.01203.2007

  • Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study. Reviewed International journal

    Kuniyuki Nakamura, Kana Ueki, Ryu Matsuo, Takuya Kiyohara, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    PloS one   18 ( 6 )   e0287721   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0287721

  • Sex Differences in Long-Term Functional Decline after Ischemic Stroke: A Longitudinal Observational Study from the Fukuoka Stroke Registry Reviewed International journal

    Fumi Irie, Ryu Matsuo, Kuniyuki Nakamura, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi; Fukuoka Stroke Registry Investigators

    Cerebrovasc Dis .   1 - 8   2023.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000526940

  • PDGFRβ-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery Reviewed

    43 ( 4 )   518 - 530   2022.12

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    Language：Others   Publishing type：Research paper (scientific journal)  

    Post-stroke intra-infarct repair promotes peri-infarct neural reorganization leading to functional recovery. Herein, we examined the remodeling of extracellular matrix proteins (ECM) that constitute the intact basal membrane after permanent middle cerebral artery occlusion (pMCAO) in mice. Among ECM, collagen type IV remained localized on small vessel walls surrounding CD31-positive endothelial cells within infarct areas. Fibronectin was gradually deposited from peri-infarct areas to the ischemic core, in parallel with the accumulation of PDGFRβ-positive cells. Cultured PDGFRβ-positive pericytes produced fibronectin, which was enhanced by the treatment with PDGF-BB. Intra-infarct deposition of fibronectin was significantly attenuated in pericyte-deficient Pdgfrb+/−mice. Phagocytic activity of macrophages against myelin debris was significantly enhanced on fibronectin-coated dishes. In contrast, laminin α2, produced by GFAP- and aquaporin 4-positive astrocytes, accumulated strongly in the boundary of peri-infarct areas. Pericyte-conditioned medium increased the expression of laminin α2 in cultured astrocytes, partly through TGFβ1. Laminin α2 increased the differentiation of oligodendrocyte precursor cells into oligodendrocytes and the expression of myelin-associated proteins. Peri-infarct deposition of laminin α2 was significantly reduced in Pdgfrb+/−mice, with attenuated oligodendrogenesis in peri-infarct areas. Collectively, intra-infarct PDGFRβ-positive cells may orchestrate post-stroke remodeling of key ECM that create optimal environments promoting clearance of myelin debris and peri-infarct oligodendrogenesis.

    DOI： 10.1177/0271678x221145092

  • Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice. Reviewed International journal

    Kei Yamanaka, Kuniyuki Nakamura, Tomoya Shibahara, Masamitsu Takashima, Hayato Takaki, Masaoki Hidaka, Motohiro Komori, Yoji Yoshikawa, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono

    Glia   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/glia.24292

  • The presence of sodium glucose co-transporter 2 in mesangial cells and pericytes and its roles in mesangial lesions and in capillaries under diabetic and ischemic conditions. Reviewed International journal

    Masanori Wakisaka, Kuniyuki Nakamura, Takanari Kitazono

    Diabetes research and clinical practice   192   110096 - 110096   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.diabres.2022.110096

  • Neurosarcoidosis Presenting with Prominent Periventricular White-Matter Lesions during Steroid Treatment for Autoimmune Hepatitis Reviewed

    Tomoya Shibahara, Fumitaka Yoshino, Mikiaki Matsuoka, Masaki Tachibana, Kuniyuki Nakamura, Tetsuro Ago, Junya Kuroda, Hiroshi Nakane

    Case Reports in Neurology   334 - 340   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000526223

  • Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study. Reviewed International journal

    Yuichiro Ohya, Ryu Matsuo, Noriko Sato, Fumi Irie, Kuniyuki Nakamura, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    PloS one   17 ( 7 )   e0268481   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0268481

  • Progressive Small-Vessel Strokes Following Antiretroviral Therapy in a Patient with Acquired Immunodeficiency Syndrome. Reviewed International journal

    Tomoya Shibahara, Kuniyuki Nakamura, Daisuke Abe, Naoki Tagawa, Yoshinobu Wakisaka, Takanari Kitazono, Tetsuro Ago

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   31 ( 5 )   106409 - 106409   2022.5

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  • Sex Differences in the Risk of 30-Day Death After Acute Ischemic Stroke. Reviewed International journal

    Fumi Irie, Ryu Matsuo, Kuniyuki Nakamura, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    Neurology. Clinical practice   11 ( 6 )   e809-e816   2021.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1212/CPJ.0000000000001087

  • Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence. Reviewed International journal

    Kenji Fukuda, Ryu Matsuo, Masahiro Kamouchi, Fumi Kiyuna, Noriko Sato, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Tsutomu Imaizumi, Hisashi Kai, Takanari Kitazono, FSR Investigators

    Stroke   53 ( 1 )   70 - 78   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/STROKEAHA.120.033751.

  • Roles of Sodium-Glucose Cotransporter 2 of Mesangial Cells in Diabetic Kidney Disease. Reviewed International journal

    Masanori Wakisaka, Kuniyuki Nakamura, Toshiaki Nakano, Takanari Kitazono

    Journal of the Endocrine Society   5 ( 8 )   bvab083   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1210/jendso/bvab083

  • β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke Reviewed International journal

    52 ( 8 )   2621 - 2628   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Background and Purpose: Little is known about how β-cell dysfunction affects clinical outcome after ischemic stroke. We examined whether β-cell function is associated with clinical outcome after acute ischemic stroke and if so, whether insulin resistance influences this association in a prospective study of patients with acute stroke. Methods: A total of 3590 nondiabetic patients with acute ischemic stroke (mean age, 71 years) were followed up for 3 months. β-Cell function was assessed using the homeostasis model assessment for β-cell function (HOMA-β). Study outcomes were poor functional outcome (modified Rankin Scale score, 3–6) and stroke recurrence at 3 months after stroke onset and neurological deterioration (≥2-point increase in the National Institutes of Health Stroke Scale score) at discharge. Logistic regression analysis was used to evaluate the association between quintile levels of serum HOMA-β and clinical outcomes. Results: The age- and sex-adjusted odds ratios for poor functional outcome and neurological deterioration increased significantly with decreasing HOMA-β levels (P for trend, <0.001 and 0.001, respectively). These associations became more prominent after adjustment for HOMA-insulin resistance and were substantially unchanged even after further adjustment for other confounders, namely, body mass index, dyslipidemia, hypertension, estimated glomerular filtration rate, stroke subtype, National Institutes of Health Stroke Scale score on admission, and reperfusion therapy (odds ratio [95&#37; CI] for the first versus fifth quintile of HOMA-β, 3.30 [2.15–5.08] for poor functional outcome and 10.69 [4.99–22.90] for neurological deterioration). Such associations were not observed for stroke recurrence. In stratified analysis for the combination of HOMA-β and HOMA-insulin resistance levels, lower HOMA-β and higher HOMA-insulin resistance levels were independently associated with increased risks of poor functional outcome and neurological deterioration. Conclusions: Our findings suggest that β-cell dysfunction is significantly associated with poor short-term clinical outcome independently of insulin resistance in nondiabetic patients with acute ischemic stroke.

    DOI： 10.1161/STROKEAHA.120.031392.

  • Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry Reviewed International journal

    Yoshinobu Wakisaka, Ryu Matsuo, Kuniyuki Nakamura, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Fukuoka Stroke Registry Investigators

    Cerebrovasc Dis.   50 ( 4 )   390 - 396   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000514368.

  • Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism Reviewed International journal

    Noriko Sato, Ryu Matsuo, Fumi Kiyuna, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, collab on behalf of the Fukuoka Stroke Registry Investigators

    Cerebrovasc Dis.   49 ( 6 )   601 - 608   2020.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000510773.

  • Epstein-Barr Virus-Associated Encephalopathy Presenting with Nonconvulsive Status Epilepticus in an Immunosuppressive State. Reviewed International journal

    Yuichiro Ohya, Kuniyuki Nakamura, Yoshinobu Wakisaka, Hiroaki Sato, Kayo Wakisaka, Masaya Kumamoto, Yohei Muraya, Junya Kuroda, Hiroshi Nakane, Goichi Yoshimoto, Takanari Kitazono, Tetsuro Ago

    Case Rep Neurol.   2020.8

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    Language：English  

    DOI： 10.1159/000507976.

  • Response to Letter regarding case report, "Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman". Reviewed International journal

    Tetsuro Ago, Kana Ueki, Yoshinobu Wakisaka, Kuniyuki Nakamura, Takanari Kitazono

    Journal of the neurological sciences   414   116925 - 116925   2020.7

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    Language：English  

    DOI： 10.1016/j.jns.2020.116925

  • An Embolic Stroke in a Patient With PROC p.Lys193del. Reviewed International journal

    Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazon, Tetsuro Ago

    J Stroke Cerebrovasc Dis.   29 ( 5 )   104597 - 104597   2020.5

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  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman. Reviewed International journal

    Kana Ueki, Yoshinobu Wakisaka, Kuniyuki Nakamura, Yuji Shono, Shinichi Wada, Yoji Yoshikawa, Yuta Matsukuma, Takeshi Uchiumi, Dongchong Kang, Takanari Kitazono, Tetsuro Ago

    J Neurol Sci.   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： DOI: 10.1016/j.jns.2020.116791

  • Smoking Status and Functional Outcomes After Acute Ischemic Stroke. Reviewed International journal

    Matsuo R, Ago T, Kiyuna F, Sato N, Nakamura K, Kuroda J, Wakisaka Y, Kitazono T; Fukuoka Stroke Registry Investigators.

    Stroke   51 ( 3 )   846 - 852   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/STROKEAHA.119.027230.

  • Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion. Reviewed International journal

    Komori M, Ago T, Wakisaka Y, Nakamura K, Tachibana M, Yoshikawa Y, Shibahara T, Yamanaka K, Kuroda J, Kitazono T.

    Brain Res.   1718   201 - 211   2019.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.brainres.2019.05.020

  • Pannexin-3 Deficiency Delays Skin Wound Healing in Mice due to Defects in Channel Functionality. Reviewed International journal

    Zhang P, Ishikawa M, Rhodes C, Doyle A, Ikeuchi T, Nakamura K, Chiba Y, He B, Yamada Y

    J Invest Dermatol.   139 ( 4 )   909 - 918   2019.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jid.2018.08.033.

  • Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons. Reviewed International journal

    Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T.

    Stroke.   48 ( 8 )   2222 - 2230   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/STROKEAHA.117.016689

  • Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. Reviewed International journal

    Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T.

    J Cereb Blood Flow Metab.   36 ( 6 )   1143 - 54   2016.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/0271678X15606456

  • A CADASIL-Like Case with a Novel Noncysteine Mutation of the NOTCH3 Gene and Granular Deposits in the Renal Arterioles. Reviewed International journal

    Kuniyuki Nakamura, Tetsuro Ago, Akihiro Tsuchimoto, Nozomi Noda, Asako Nakamura, Toshiharu Ninomiya, Takeshi Uchiumi, Kazuhiko Tsuruya, Masahiro Kamouchi, Hiroaki Ooboshi, Takanari Kitazono

    Case reports in neurological medicine   2015   431461 - 431461   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1155/2015/431461

  • Nox4 is a major source of superoxide production in human brain pericytes. Reviewed International journal

    Kuroda J, Ago T, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kamouchi M, Kitazono T.

    J Vasc Res.   51 ( 6 )   429 - 38   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000369930

  • Neurotrophin production in brain pericytes during hypoxia: a role of pericytes for neuroprotection. Reviewed International journal

    Ishitsuka K, Ago T, Arimura K, Nakamura K, Tokami H, Makihara N, Kuroda J, Kamouchi M, Kitazono T.

    Microvasc Res.   83 ( 3 )   352 - 9   2012.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.mvr.2012.02.009

  • Change in Intracellular pH causes the toxic Ca2+ entry via NCX1 in neuron- and glia-derived cells. Reviewed International journal

    Shono Y, Kamouchi M, Kitazono T, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida M.

    Cell Mol Neurobiol.   30 ( 3 )   453 - 60   2010.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10571-009-9470-7

  • Midkine gene transfer protects against focal brain ischemia and augments neurogenesis. Reviewed International journal

    Ishikawa E, Ooboshi H, Kumai Y, Takada J, Nakamura K, Ago T, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M.

    J Neurol Sci.   285 ( 1-2 )   78 - 84   2009.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jns.2009.05.026

  • Hemorrhagic shock and obstructive uropathy due to a large rectus sheath hematoma in a patient on anticoagulant therapy. Reviewed

    Jiro Toyonaga, Kazuhiko Tsuruya, Kohsuke Masutani, Hiroto Maeda, Kuniyuki Nakamura, Masatomo Taniguchi, Hideki Hirakata, Mitsuo Iida

    Internal medicine (Tokyo, Japan)   48 ( 24 )   2119 - 22   2009.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes. Reviewed International journal

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Shono Y, Hagiwara N, Ago T, Ooboshi H, Ibayashi S, Iida M.

    Microvasc Res.   77 ( 3 )   327 - 34   2009.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.mvr.2008.12.001

  • Combined and staged endovascular recanalization of cervical and intracranial arteries in hyperacute ischemic stroke. Reviewed

    Kazunori Toyoda, Ken Uda, Akiko Shirakawa, Kotaro Yasumori, Kuniyuki Nakamura, Tooru Inoue, Yasushi Okada

    Internal medicine (Tokyo, Japan)   46 ( 23 )   1935 - 6   2007.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Hydrogen peroxide-induced Ca2+ responses in CNS pericytes. Reviewed International journal

    Kamouchi M, Kitazono T, Ago T, Wakisaka M, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida M.

    Neurosci Lett.   416 ( 1 )   12 - 6   2007.4

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Books

  • 脳梗塞急性期と慢性期の抗血小板療法．最新主要文献でみる脳神経外科学レビュー2023-24

    中村 晋之（ Role： Joint author）

    総合医学社  2022.10 

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    Responsible for pages：82-8   Language：Japanese  

  • 細胞外マトリックス．最新臨床脳卒中学（第2版）（下）

    中村 晋之

    日本臨牀社  2022.2 

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    Language：Japanese  

  • 脳梗塞急性期と慢性期の抗血小板療法．最新主要文献でみる脳神経外科学レビュー2019

    中村晋之

    総合医学社  2019.8 

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    Responsible for pages：77-83   Language：Japanese   Book type：Scholarly book

  • 内皮細胞・周皮細胞の立場から．　　最新臨床脳卒中学（上）

    中村晋之，吾郷哲朗

    2014.6 

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    Language：Japanese  

  • 慢性期再発予防のコツ．　レジデントのための脳卒中診療のコツ，阿部康二（編）

    中村晋之，北園孝成

    2014.6 

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    Language：Japanese  

  • データバンクにおける脳梗塞病型別頻度と久山町における時代的推移．脳卒中データバンク2009， 小林祥泰（編）

    中村晋之，井林雪郎，金大成

    2009.6 

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    Language：Japanese  

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Presentations

  • 脳梗塞後のneurovascular unit修復過程におけるペリサイト保護戦略． Invited

    中村晋之、清原卓也、脇坂義信、吾郷哲朗、北園孝成．

    第64回脳循環代謝学会学術集会  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • ペリサイトを標的とした脳梗塞治療戦略 Invited

    中村晋之、吾郷哲朗、高島正光、芝原友也、清原卓也、脇坂義信、北園孝成

    第48回日本脳卒中学会学術集会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • Perlecan Regulates Pericyte Dynamics in the Repair Process of the Blood-Brain Barrier against Ischemic Stroke International conference

    Nakamura K, Ikeuchi T, Zhang P, Rhodes C, Chiba Y, Ago T, Mukouyama YS, Yamada Y

    International Stroke Conference 2018  2018.1 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Macrophage infiltration is required for pericyte recruitment in poststroke tissue repair. International conference

    Hidaka M, Nakamura K, Yoshino F, Takashima M, Kiyohara T, Wakisaka Y, Kitazono T, Ago T

    Neuroscience 2023  2023.11 

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    Event date： 2023.11

    Language：English  

    Country：United States  

  • 抗凝固療法新時代における課題と戦略． Invited

    中村 晋之

    第64回脳循環代謝学会学術集会  2023.11 

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    Event date： 2023.11

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：福岡   Country：Japan  

  • Nox4 plays crucial role in angiogenic responses and in recruitment of pericytes and macrophages in poststroke tissue repair. International conference

    Nakamura K, Hidaka M, Yoshino F, Takashima M, Kiyohara T, Wakisaka Y, Kitazono T, Ago T.

    Neuroscience 2023  2023.11 

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    Event date： 2023.11

    Language：English  

    Country：United States  

  • 脳卒中二次予防における病態とエビデンスを考慮した危険因子の管理． Invited

    中村 晋之

    地域医師のための生涯研修セミナー  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州医療センター   Country：Japan  

  • 脳梗塞における糖代謝異常の病態と管理 Invited

    中村晋之、吾郷哲朗、清原卓也、松尾龍、脇坂義信、鴨打正浩、北園孝成.

    第48回日本脳卒中学会学術集会  2023.3 

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    Event date： 2023.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：横浜   Country：Japan  

  • Decrease in serum uric acid levels are associated with unfavorable outcomes after ischemic stroke. International conference

    Nakamura K, Ueki K, Matsuo R, Kiyohara T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T.

    The 10th Korea-Japan Joint Stroke Conference  2022.9 

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    Event date： 2022.9

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 脳卒中における血圧と心不全の管理. Invited

    @中村 晋之

    第5回日本神経学会特別教育研修会：脳卒中コース  2022.7 

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    Event date： 2022.7 - 2023.5

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：長崎   Country：Japan  

  • グリア瘢痕におけるlaminin α2再構築が脳梗塞後の再髄鞘化を促進し、機能回復に関与する

    中村晋之、芝原友也、脇坂義信、吾郷哲朗、北園孝成

    第53回日本結合組織学会学術大会  2021.6 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：順天堂大学(Web)   Country：Japan  

  • 血清尿酸値低値は脳梗塞後の短期機能転帰不良に関連する：Fukuoka Stroke Registry

    中村晋之、松尾龍、植木香奈、脇坂義信、吾郷哲朗、鴨打正浩、北園孝成

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • 脳梗塞後のペリサイト-アストロサイト-細胞外マトリックス連関を介した組織修復および機能回復 Invited

    中村晋之、吾郷哲朗、芝原友也、脇坂義信、北園孝成

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • 脳卒中研究のススメ　基礎 Invited

    中村晋之

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Japan  

  • 脳梗塞後のNVU修復過程における細胞外マトリックスタンパク質の重要性

    中村晋之, Yoh-suke Mukouyama, 平澤恵理, 脇坂義信, 吾郷哲朗, 北園孝成, Yoshihiko Yamada

    日本脳循環代謝学会学術集会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • Role of NHE1 in calcium oscillation and cell proliferation in human CNS pericytes. International conference

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ooboshi H, Ibayashi S, Iida M.

    The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function  2007.5 

    　More details

    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Expression of NHE1 and cell proliferation in human CNS pericytes. International conference

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M.

    The 2nd Meeting of Asian Stroke Forum  2007.9 

    　More details

    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Brain-derived neurotrophic factor and its related factors after ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) – International conference

    2011.5 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Hamburg   Country：Germany  

  • The expression of pericyte PDGFRβ is regulated by basic FGF after ischemic stroke. International conference

    2013.11 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：San Diego   Country：United States  

  • Temporal profile of basic fibroblast growth factor and its clinical implications in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS)- International conference

    Nakamura K, Ago T, Matsuo R, Kuroda J, Wakisaka Y, Isomura T, Awano H, Suzuki K, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T.

    Neuroscience 2013  2013.11 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Basic fibroblast growth factor after ischemic stroke in diabetic patients - Research for Biomarkers in Ischemic Stroke (REBIOS) - International conference

    Nakamura K, Ago T, Arimura K, Makihara N, Nishimura A, Matsuo R, Wakisaka Y, Kuroda J, Isomura T, Awano H, Suzuki K, Okada Y, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T.

    International Stroke Conference 2014  2014.2 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Deficiency of Perlecan, a basement membrane heparan sulfate proteoglycan, leads to the blood-brain barrier deterioration in a mouse ischemic stroke model. International conference

    Nakamura K, Zhang P, Ikeuchi T, Rhodes C, Mahboubi D, Chiba Y, Ago T, Mukouyama YS, Yamada Y.

    Neuroscience 2016  2016.11 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Perlecan Is Required for the Maintenance of the Blood-Brain Barrier through the Interaction with Pericytes in a Mouse Ischemic Stroke Model. International conference

    Nakamura K, Ikeuchi T, Zhang P, Rhodes C, Chiba Y, Ago T, Mukouyama YS, Yamada Y.

    International Stroke Conference 2017  2017.2 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Perlecan is essential for the maintenance and repair of the blood-brain barrier against ischemic stroke through interacting with and activating pericytes. International conference

    Nakamura K, Ikeuchi T, Zhang P, Rhodes C, Chiba Y, Ago T, Mukouyama YS, Yamada Y.

    Neuroscience 2017  2017.11 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • 細胞外マトリックス蛋白Perlecanは脳梗塞後のペリサイトの遊走を促進し、血液脳関門の修復に関与する

    中村晋之、吾郷哲朗、平澤恵理、向山洋介、山田吉彦

    第50回日本結合組織学会学術大会  2018.6 

    　More details

    Event date： 2018.6

    Language：Japanese  

    Venue：福岡   Country：Japan  

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MISC

  • Pericyte-Mediated Molecular Mechanisms Underlying Tissue Repair and Functional Recovery after Ischemic Stroke.

    Kuniyuki Nakamura, Tetsuro Ago

    J Atheroscler Thromb.   2023.9

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳血管ペリサイトの生理的役割と脳虚血応答

    中村晋之, 吾郷哲朗

    脳循環代謝（日本脳循環代謝学会機関誌）   2014.6

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    Language：Japanese  

    Neurovascular unit は神経細胞，脳血管内皮細胞，ペリサイト（血管周皮細胞），アストロサイト（星状膠細胞）などを構成単位とする概念である．これらの細胞は互いに密接かつ複雑に関わっており，血液脳関門や微小循環の調節など多彩な脳機能の維持を担っている．なかでもペリサイトは内皮細胞を被覆して血管を物理的に安定化させるのみならず，内皮細胞と相互に作用し，微小血管の成熟，安定化，血液脳関門の維持などに重要な役割を果たしている．脳虚血時にペリサイトは虚血周囲へ誘導され，サイトカインや神経栄養因子の分泌を行って周囲の細胞に作用し，神経細胞の保護，破綻したBBB の再構築，さらには血管・神経再生を促進している可能性がある．ペリサイトはNVU の保護や修復過程において中心的な役割を果たしている可能性が考えられ，脳虚血や認知症など種々の中枢神経疾患に対する新たな治療標的として期待される．

    DOI： 10.16977/cbfm.25.2_109

  • Roles of Sodium-Glucose Cotransporter 2 of Mesangial Cells in Diabetic Kidney Disease. Reviewed

    Masanori Wakisaka, Kuniyuki Nakamura, Toshiaki Nakano, Takanari Kitazono

    Journal of the Endocrine Society   2021.8

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    Language：English  

    DOI： 10.1210/jendso/bvab083

  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A > G mutation in a 76-year-old woman. Reviewed

    Kana Ueki, Yoshinobu Wakisaka, Kuniyuki Nakamura, Yuji Shono, Shinichi Wada, Yoji Yoshikawa, Yuta Matsukuma, Takeshi Uchiumi, Dongchong Kang, Takanari Kitazono, Tetsuro Ago

    J Neurol Sci.   2020.5

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    Language：English  

    DOI： 10.1016/j.jns.2020.116791

  • 【新しい『高尿酸血症・痛風の治療ガイドライン』を読み解く】合併症の管理はどう変わったのか 脳血管障害 血清尿酸値と脳卒中

    中村晋之, 吾郷哲朗, 北園孝成

    2019.12

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    Language：Japanese  

  • 時間で追う脳虚血の病態と治療:(2)亜急性期 脳梗塞後のNVU修復過程における細胞外マトリックスタンパク質の重要性

    中村 晋之, Mukouyama Yoh-suke, 平澤 恵理, 脇坂 義信, 吾郷 哲朗, 北園 孝成, Yamada Yoshihiko

    脳循環代謝   2019.11

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    Language：Japanese  

  • 脳卒中は遺伝するか

    中村 晋之, 北園 孝成

    2018.7

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    Language：Japanese  

  • 脳保護戦略の新展開

    中村晋之, 吾郷哲朗, 北園孝成

    2015.1

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    Language：Japanese  

  • アストロサイトは MEGF10 および MERTK 経路を介してシナプス除去に関与する

    中村晋之, 黒田淳哉

    2014.2

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    Language：Japanese  

  • Notch3非典型的変異によりCADASIL様の臨床症候を呈した一例

    山田 奈津子, 中村 晋之, 吾郷 哲朗, 中村 麻子, 二宮 利治, 鶴屋 和彦, 鴨打 正浩, 北園 孝成, 康 東天

    臨床神経学   2011.8

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    Language：Japanese  

  • 脳卒中危険因子と血液脳関門障害

    中村晋之, 北園孝成

    2010.9

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    Language：Japanese  

  • Potential augmentation of neurogenesis by post-ischemic gene transfer of midkine

    Eiichi Ishikawa, Hiroaki Ooboshi, Yasuhiro Kumai, Junichi Takada, Kuniyuki Nakamura, Junya Kuroda, Hiroshi Sugimori, Masahiro Kamouchi, Takanari Kitazono, Setsurou Ibayashi, Mitsuo Iida

    STROKE   2008.2

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    Language：English  

  • 脳血管障害の発症抑制作用

    中村晋之, 井林雪郎

    2007.9

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    Language：Japanese  

  • くも膜下出血の疫学とリスクファクター

    中村晋之, 井林雪郎

    2007.6

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    Language：Japanese  

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Professional Memberships

  • The Japanese Society of Internal Medicine

  • The Japan Stroke Society

  • The Japan Geriatrics Society

  • The Japanese Society of Neurology

  • The Japanese Society of Cerebral Blood Flow and Metabolism

  • The American Heart Association and American Stroke Association

  • The Society for Neuroscience

  • The International Society of Cerebral Blood Flow and Metabolism

  • The Japanese Society of Matrix Biology and Medicine

  • Japan Society for Dementia Research

  • The Japanese Headache Society

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Committee Memberships

  • 日本脳循環代謝学会   代議員   Domestic

    2013.11 - Present   

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2023

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：16

  • Screening of academic papers

    Role(s)： Peer review

    2022

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：9

  • Screening of academic papers

    Role(s)： Peer review

    2021

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • Screening of academic papers

    Role(s)： Peer review

    2020

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：5

  • Screening of academic papers

    Role(s)： Peer review

    2019

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • Screening of academic papers

    Role(s)： Peer review

    2018

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2016

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2015

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

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Research Projects

  • 脳梗塞機能回復治療への挑戦 - ペリサイトをいかに再動員させるか?

    Grant number：24K02556  2024 - 2027

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • SGLT2を標的とした脳梗塞後のペリサイト機能維持機構の探索

    Grant number：22K09236  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 血清尿酸値が急性期脳梗塞発症後の転帰に及ぼす影響に関する検討

    2021

    公益財団法人 痛風・尿酸財団 研究助成

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    Authorship：Principal investigator  Grant type：Contract research

  • 脳虚血病態におけるペリサイトの細胞死にフェロトーシスは関与するか?

    Grant number：20K09373  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 脳梗塞におけるペリサイトを介した組織修復および機能回復機構の解明

    2020 - 2021

    持田記念医学薬学振興財団　研究助成金

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    Authorship：Principal investigator  Grant type：Contract research

  • 細胞外マトリックスperlecanによる脳血管障害の新規修復治療法の開発

    Grant number：19K09511  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 脳血管障害後の組織修復に細胞外マトリックスperlecanが与える影響に関する研究

    2018

    先進医薬研究振興財団　循環医学分野 若手研究者助成

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    Authorship：Principal investigator  Grant type：Contract research

  • Neurovascular unit の発生と修復におけるPerlecan の意義

    2015

    上原記念生命科学財団　リサーチフェローシップ

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    Authorship：Principal investigator  Grant type：Contract research

  • 脳虚血に対する細胞移植治療におけるペリサイトの果たす役割

    Grant number：26861169  2014

    科学研究費助成事業  若手研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 脳虚血に対する細胞移植治療における脳血管ペリサイトの果たす役割

    2014

    貝原守一医学振興財団　研究助成金

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    Authorship：Principal investigator  Grant type：Contract research

  • 脳血管周皮細胞の細胞内カルシウム応答が脳虚血に及ぼす影響に関する研究

    2009

    先進医薬研究振興財団　循環医学分野 萌芽研究助成

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

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Class subject

  • ５年生ベッドサイド実習

    2024.4 - 2025.3   Full year

  • 6年生クリニカルクラークシップ

    2024.4 - 2025.3   Full year

  • 3年生概説講義「神経」

    2023.10 - 2024.3   Second semester

  • 6年生クリニカルクラークシップ

    2023.4 - 2024.3   Full year

  • ５年生ベッドサイド実習

    2023.4 - 2024.3   Full year

  • 4年生臨床医学基本実習

    2023.4 - 2023.9   First semester

  • 3年生概説講義「神経」

    2022.10 - 2023.3   Second semester

  • 6年生クリニカルクラークシップ

    2022.4 - 2023.3   Full year

  • ５年生ベッドサイド実習

    2022.4 - 2023.3   Full year

  • 4年生臨床医学基本実習

    2022.4 - 2022.9   First semester

  • 4年生臨床医学基本実習「神経系の診察」

    2021.10 - 2022.3   Second semester

  • 3年生概説講義「神経」

    2021.10 - 2022.3   Second semester

  • 6年生クリニカルクラークシップ

    2021.4 - 2021.9   First semester

  • ５年生ベッドサイド実習

    2021.4 - 2021.9   First semester

  • 3年生概説講義「神経」

    2020.10 - 2021.3   Second semester

  • 6年生クリニカルクラークシップ

    2020.4 - 2020.9   First semester

  • ５年生ベッドサイド実習

    2020.4 - 2020.9   First semester

  • 3年生概説講義「神経」

    2019.10 - 2020.3   Second semester

  • 6年生クリニカルクラークシップ

    2019.4 - 2019.9   First semester

  • ５年生ベッドサイド実習

    2019.4 - 2019.9   First semester

  • 3年生概説講義「神経」

    2018.10 - 2019.3   Second semester

  • ５年生ベッドサイド実習

    2018.4 - 2018.9   First semester

  • 6年生クリニカルクラークシップ

    2018.4 - 2018.9   First semester

▼display all

Travel Abroad

  • 2015.4 - 2018.3

    Staying countory name 1：United States   Staying institution name 1：National Institutes of Health/National Institute of Dental and Craniofacial Research/Molecular Biology Section

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Stroke Science

Clinician qualification

  • Specialist

    The Japan Stroke Society

  • Specialist

    The Japan Geriatrics Society

  • Specialist

    The Japanese Society of Internal Medicine（JSIM）

Year of medical license acquisition

  • 2003

Notable Clinical Activities

  • 脳卒中ホットラインに対応し脳卒中センターにおける急性期脳血管障害の診療に携わっている。