Updated on 2025/07/17

Information

 

写真a

 
TAKAHASHI YOSHIAKI
 
Organization
Kyushu University Hospital Pediatric Surgery Assistant Professor
Kyushu University Hospital Pediatric Surgery(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425573
Profile
九州大学病院小児外科において、臨床および研究に従事する。
External link

Research Areas

  • Life Science / General surgery and pediatric surgery

Degree

  • 医学博士

Research History

  • 新潟大学医歯学総合病院 小児外科   

Education

  • Oita University   医学部   医学科

    2002.4 - 2009.3

Research Interests・Research Keywords

  • Research theme: Factors predicting the need for liver transplantation in biliary atresia patients after 18 years of age

    Keyword: biliary atresia, adult, liver transplantation

    Research period: 2023.10 - 2024.12

Awards

  • 第44回日本胆道閉鎖症研究会 優秀演題賞

    2017.10  

Papers

  • Factors predicting the need for liver transplantation in biliary atresia patients after 18 years of age. Reviewed International journal

    Yoshiaki Takahashi

    Pediatric Surgery International   40 ( 1 )   2024.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer  

    Adult biliary atresia patients have limited options for liver transplantation to the lack of donor candidates and the low prevalence of deceased donors. The elucidation of prognostic factors for liver transplantation in adulthood is important. APRI was the most useful marker.

    DOI: 10.1007/s00383-024-05805-x.

  • 特集 異物の診断と治療 磁性玩具による消化管損傷

    松浦 俊治, 山口 修輝, 鳥井ケ原 幸博, 馬庭 淳之介, 髙橋 良彰, 福田 篤久, 川久保 尚徳, 吉丸 耕一朗, 永田 公二, 田尻 達郎

    小児外科   57 ( 6 )   633 - 637   2025.6   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000001226

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  • 特集 小児外科疾患のQOL;最近の話題 先天性胆道拡張症術後膵内遺残胆管

    吉丸 耕一朗, 松浦 俊治, 高橋 良彰, 鳥井ケ原 幸博, 内田 康幸, 前田 翔平, 梶原 啓資, 白井 剛, 田尻 達郎

    小児外科   57 ( 5 )   545 - 549   2025.5   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000001200

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  • Serum Lactate Clearance as a Predictive Biomarker for Optimal Graft Perfusion in Living Donor Liver Transplantation

    Kajihara, K; Matsuura, T; Uchida, Y; Shohei, M; Toriigahara, Y; Takahashi, Y; Tajiri, T

    JOURNAL OF PEDIATRIC SURGERY   60 ( 2 )   161647   2025.2   ISSN:0022-3468 eISSN:1531-5037

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    Language:English   Publisher:Journal of Pediatric Surgery  

    Background: The optimal balance between the graft volume (GV) and portal venous flow (PVF) in living donor liver transplantation (LDLT) is unclear. As lactate is mainly metabolized in the liver, perioperative lactate levels are reportedly a useful biomarker for early graft dysfunction (EGD). The present study analyzed perioperative lactate levels according to the PVF. Methods: The PVF/GV (mL/min per 100 g GV) of 97 recipients from 1996 to 2022 was retrospectively classified as low (LPVF; PVF/GV ≤ 100, N = 29), moderate (MPVF; PVF/GV 100–250, N = 40), or high (HPVF; PVF/GV > 250, N = 28). Lactate levels were obtained preoperatively (L0), immediately after graft reperfusion (L1), 4 h after reperfusion (L2), and on postoperative day 3 (L3). The lactate clearances were then calculated. Results: The lower the PVF/GV ratio, the younger the age at LDLT and the higher the graft-to-recipient weight ratio. The median L2 and L3 in the HPVF group were significantly higher than those in the other groups (p = 0.019 and p = 0.003, respectively). The median ΔL1 in the HPVF group was lower than that in the LPVF and MPVF groups (0.23 vs. 0.50, p < 0.0001 and 0.23 vs. 0.41, p = 0.011, respectively). ΔL1 was negatively correlated with the PVF/GV. Although no patient had EGD, three patients with HPVF with low ΔL1 developed small-for-size syndrome. Conclusions: Graft hyperperfusion may delay the recovery of the graft function and result in poor lactate clearance. The combination of the PVF/GV and lactate clearance may be useful as a prognostic marker for optimal graft perfusion in LDLT. Level of evidence: IV.

    DOI: 10.1016/j.jpedsurg.2024.07.032

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  • 特集 極・超低出生体重児の治療戦略 閉塞性黄疸

    吉丸 耕一朗, 松浦 俊治, 内田 康幸, 前田 翔平, 近藤 琢也, 高橋 良彰, 福田 篤久, 川久保 尚徳, 永田 公二, 田尻 達郎

    小児外科   57 ( 1 )   76 - 81   2025.1   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000001068

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  • Portal cavernoma cholangiopathy in pediatric extrahepatic portal vein obstruction with or without shunt surgery

    Matsuura, T; Yanagi, Y; Maeda, S; Uchida, Y; Kajihara, K; Toriigahara, Y; Takahashi, Y; Kawakubo, N; Nagata, K; Tajiri, T

    PEDIATRICS INTERNATIONAL   67 ( 1 )   e70061   2025.1   ISSN:1328-8067 eISSN:1442-200X

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    Language:English   Publisher:Pediatrics International  

    Background: Portal cavernoma cholangiopathy (PCC) has recently been recognized as an abnormality of the intrahepatic and extrahepatic bile ducts caused by external compression by the portal cavernoma or ischemia in the biliary region. Although extrahepatic portal vein obstruction (EHPVO) is common in children with portal hypertension, the association between surgical treatment for EHPVO and the incidence of PCC in children is not well known. Methods: We retrospectively reviewed the medical records of 14 cases of childhood-onset EHPVO in our department. PCC was defined by intra- and extrahepatic bile duct irregularities on imaging, both symptomatic and asymptomatic. Results: There were six cases with PCC (Group A) and eight cases without PCC (Group B). EHPVO was diagnosed at 4.8 years and 4.1 years of age in Groups A and B, respectively. PCC was asymptomatic, except in one patient with repeated cholangitis. In Group A, 4/6 patients (66.7%) showed sufficient intrahepatic portal vein inflow via cavernoma at hilum, whereas in Group B, almost all cases (7/8 cases, 87.5%) showed poor intrahepatic portal vein delineation. PCC did not develop in 4/5 patients (80%) who underwent portosystemic shunt surgery, such as mesocaval shunting. Conclusions: PCC is a serious complication of EHPVO that affects its long-term prognosis. Although there are concerns about long-term problems such as hyperammonemia and pulmonary complications after portosystemic shunt surgery, it may also be beneficial as a prophylactic surgery for PCC.

    DOI: 10.1111/ped.70061

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  • 特集 Hirschsprung病類縁疾患-診断・治療最前線- Immaturity of ganglia 病理診断

    吉丸 耕一朗, 内田 康幸, 松浦 俊治, 前田 翔平, 髙橋 良彰, 鴨打 周, 濱田 洋, 福原 雅弘, 川久保 尚徳, 永田 公二, 岩崎 健, 田口 智章, 小田 義直, 田尻 達郎

    小児外科   56 ( 12 )   1232 - 1236   2024.12   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000001030

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  • A Case of Mitochondrial DNA Depletion Syndrome With Hepatocellular Carcinoma in the Explanted Native Liver During Living-Donor Liver Transplantation

    Uchida Yasuyuki, Matsuura Toshiharu, Kajihara Keisuke, Maeda Shohei, Toriigahara Yukihiro, Tamaki Akihiko, Takahashi Yoshiaki, Tajiri Tatsuro

    Journal of the Japanese Society of Pediatric Surgeons   60 ( 6 )   949 - 953   2024.10   ISSN:0288609X eISSN:21874247

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    Language:Japanese   Publisher:The Japanese Society of Pediatric Surgeons  

    <p>MPV17-related mitochondrial DNA depletion syndrome has a poor prognosis; nonetheless, depending on the mutated gene, there have been some cases of survival after liver transplantation with few neurological complications. However, there have been reports of a poor prognosis after liver transplantation in patients with neurological disorders prior to the procedure. Therefore, the indications for liver transplantation remain controversial. The patient was a 14-year-old girl. She was diagnosed as having MPV17-related mitochondrial DNA depletion syndrome at the age of 3 years on the basis of the liver biopsy finding of decreased mitochondrial DNA levels and the skin biopsy findings of c.293C>T and c376-1G>A gene mutations. Living donor liver transplantation from her father was performed for decompensated cirrhosis at 14 years of age. Hepatocellular carcinoma was incidentally detected in the explanted liver. Two years after liver transplantation, there was no evidence of rejection, liver dysfunction, or recurrence of hepatocellular carcinoma. However, her neurological symptoms gradually worsened. Careful consideration of the indications for liver transplantation in each case and further investigation of life and neurological prognoses after liver transplantation are needed.</p>

    DOI: 10.11164/jjsps.60.6_949

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  • Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders

    Yoshimaru, K; Matsuura, T; Uchida, Y; Sonoda, S; Maeda, S; Kajihara, K; Kawano, Y; Shirai, T; Toriigahara, Y; Kalim, AS; Zhang, XY; Takahashi, Y; Kawakubo, N; Nagata, K; Yamaza, H; Yamaza, T; Taguchi, T; Tajiri, T

    SURGERY TODAY   54 ( 9 )   977 - 994   2024.9   ISSN:0941-1291 eISSN:1436-2813

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    Language:English   Publisher:Surgery Today  

    Hirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy. Notably, HSCR involving the small intestine, isolated hypoganglionosis, chronic idiopathic intestinal pseudo-obstruction, and megacystis-microcolon-intestinal hypoperistalsis syndrome carry a poor prognosis. Ultimately, small-bowel transplantation (SBTx) is necessary for refractory cases, but it is highly invasive and outcomes are less than optimal, despite advances in surgical techniques and management. Thus, regenerative therapy has come to light as a potential form of treatment involving regeneration of the enteric nervous system, mesenchyme, and smooth muscle in affected areas. We review the cutting-edge regenerative therapeutic approaches for managing HSCR and AD-HSCR, including the use of enteric nervous system progenitor cells, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells as cell sources, the recipient intestine's microenvironment, and transplantation methods. Perspectives on the future of these treatments are also discussed.

    DOI: 10.1007/s00595-023-02741-6

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  • Qualitative inductive analysis of the lives of women with persistent cloaca based on their narratives

    Miyata, J; Hamada, Y; Hayashishita, S; Fujita, A; Izaki, T; Obata, S; Kondo, T; Fukuta, A; Kawakubo, N; Nagata, K; Tamaki, A; Maniwa, J; Takahashi, Y; Matsuura, T; Taguchi, T; Tajiri, T

    PEDIATRIC SURGERY INTERNATIONAL   40 ( 1 )   236   2024.8   ISSN:0179-0358 eISSN:1437-9813

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    Language:English   Publisher:Pediatric Surgery International  

    Purpose: The study aimed to explore and describe the lives of patients with persistent cloaca (PC) from childhood to adulthood. Methods: Semistructured interviews were conducted with nine adult patients with PC. Their experiences and thoughts regarding this disease were analyzed qualitatively and inductively. Results: After classifying the experiences and thoughts of patients with PC, 13 categories were extracted. The following five themes emerged from these categories. (1) Difficulties with excretion and vaginal management because of the disease. (2) The degree of understanding of those around them and society has a huge effect on their way of life. (3) The inferiority of a woman who is not a “normal woman.” (4) A “never-ending disease” in which problems continue even after the transition period. (5) Differences in the central point of the narrative depending on the age group. Conclusions: In this study, qualitative and inductive analyses of data from semistructured interviews with patients with PC revealed their experiences and thoughts. The results will provide a guide for young patients and the medical professionals who treat them. Accordingly, monitoring their lives until adulthood is necessary.

    DOI: 10.1007/s00383-024-05807-9

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  • A retrospective study investigating the risk of graft loss in living donor liver transplant cases where size mismatching is predicted from graft-to-recipient weight ratio

    Toriigahara, Y; Matsuura, T; Takahashi, Y; Uchida, Y; Kajihara, K; Maeda, S; Kawakubo, N; Nagata, K; Tajiri, T

    PEDIATRIC SURGERY INTERNATIONAL   40 ( 1 )   229   2024.8   ISSN:0179-0358 eISSN:1437-9813

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    Language:English   Publisher:Pediatric Surgery International  

    Background/purpose: Living donor liver transplantation (LDLT) is vital for pediatric end-stage liver disease due to organ shortages. The graft-to-recipient weight ratio (GRWR) preoperatively measured predicts the outcomes of LDLT. We typically target between 0.8 and 3.0–4.0%, but the ideal GRWR remains controversial. We compared the outcomes of LDLT according to the GRWR to examine whether the criteria could be expanded while ensuring safety. Methods: We retrospectively reviewed 99 patients who underwent LDLT in our department by dividing them into three groups according to their GRWR: Group S, with GRWR values lower than the normal range (GRWR < 0.8%); Group M, with GRWR values in the normal range (GRWR ≥ 0.8 to < 3.5%); and Group L, with GRWR values above the normal range (GRWR ≥ 3.5%). Results: In Groups S and L, 46.2 and 44.4% of patients underwent splenectomy and delayed abdominal wall closure, respectively. After these intraoperative adjustments, there were no significant differences between the groups in 5-year patient survival, 5-year graft survival, or the occurrence of post-transplantation thrombosis. Conclusion: When the GRWR is beyond the normal threshold, the risk of complications associated with graft size might be reduced by adjustments to provide appropriate portal blood flow and by delayed abdominal wall closure.

    DOI: 10.1007/s00383-024-05814-w

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  • Factors predicting the need for liver transplantation in biliary atresia patients after 18 years of age

    Takahashi, Y; Matsuura, T; Maeda, S; Uchida, Y; Kajihara, K; Toriigahara, Y; Kawakubo, N; Nagata, K; Tajiri, T

    PEDIATRIC SURGERY INTERNATIONAL   40 ( 1 )   218   2024.8   ISSN:0179-0358 eISSN:1437-9813

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    Language:English   Publisher:Pediatric Surgery International  

    Purpose: We aimed to identify factors predicting the need for future liver transplantation (LT) at 18 years of age in patients with biliary atresia (BA). Methods: BA patients with native liver survival at > 18 years of age were retrospectively reviewed. The clinical characteristics, outcomes, hepatobiliary function, and liver fibrosis markers of native liver survivors (NLS group) were compared with patients who subsequently underwent LT (LT group). Results: The study population included 48 patients (NLS, n = 34; LT, n = 14). The male-to-female ratio, age at Kasai procedure, and type of BA in the two groups did not differ to a statistically significant extent. There was no significant difference in the MELD scores between the groups at 18 years of age. The aspartate aminotransferase-to-platelet ratio index (APRI), albumin-bilirubin (ALBI), and BA liver fibrosis (BALF) scores at 18 years of age were significantly higher in the LT group. The AUCs for APRI, ALBI, and BALF were 0.91, 0.79, and 0.85, respectively. Conclusion: Adult BA patients have limited options for LT owing to the lack of donor candidates and the low prevalence of deceased donors. The elucidation of prognostic factors for LT in adulthood is important. APRI was the most useful marker in this study.

    DOI: 10.1007/s00383-024-05805-x

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  • 特集 門脈血行異常に対する治療up to date 門脈血行異常症に合併する肝腫瘤

    梶原 啓資, 松浦 俊治, 前田 翔平, 内田 康幸, 鳥井ケ原 幸博, 髙橋 良彰, 田尻 達郎

    小児外科   56 ( 5 )   498 - 501   2024.5   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000000821

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  • 特集 胆道閉鎖症の研究update 囊胞型胆道閉鎖症と乳児早期の先天性胆道拡張症

    白井 剛, 梶原 啓資, 内田 康幸, 前田 翔平, 鳥井ヶ原 幸博, 高橋 良彰, 松浦 俊治, 田尻 達郎

    小児外科   56 ( 2 )   134 - 137   2024.2   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000000717

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  • Early and late outcomes of congenital biliary dilatation in pediatric patients Reviewed International journal

    Yoshiaki Takahashi, Takashi Kobayashi, Yoshiaki Kinoshita, Yuhki Arai, Toshiyuki Ohyama, Naoki Yokota, Yu Sugai, Shoichi Takano

    Pediatrics International   66 ( 1 )   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/ped.15712.

  • 脳死小腸移植時にドナー腹直筋鞘を用いて一期的閉腹を施行した一例

    Matsuura Toshiharu, Maeda Shohei, Uchida Yasuyuki, Takahashi Yoshiaki, Tajiri Tatsuro

    Japanese Journal of Transplantation   59 ( Supplement )   s385_1 - s385_1   2024   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:The Japan Society for Transplantation  

    <p>【はじめに】小腸移植症例は、多段階開腹手術や腹腔容積の減少、腹壁の柔軟性の低下などから、移植時、腹壁閉鎖困難が予測されることがある。しかしながら、本邦では、海外からの報告にあるような腹壁移植を行うことはできないのが現状である。今回、われわれは、脳死小腸移植の際にドナーから腹直筋鞘を採取し、腹壁再建を行ったため報告する。【症例】30歳、男性。日齢16に空腸狭窄に対し狭窄解除術を、21歳時に絞扼性イレウスに対して回盲部を含む約80cmの腸管切除を受けた。術後に難治性小腸皮膚瘻を形成し、さらにその後複数回の手術を経て、短腸症となり、中心静脈栄養を必要とした。繰り返すカテーテル関連合併症から、脳死小腸移植の適応と判断し、腹壁閉鎖困難が予測されたため、脳死ドナーから腹直筋鞘を採取し腹壁の再建に使用する方針とした。移植腸管は小腸360cm、結腸17cmで、SMA,SMVをそれぞれ吻合し、再灌流した。術前の予測通り本人の腹壁筋膜では閉鎖が困難で、採取した腹直筋鞘を用いて縫合閉鎖した。その後は徐々に腸瘻からの経腸栄養、経口摂取を開始し、静脈栄養から離脱し、POD54に自宅退院とした。【まとめ】脳死ドナーからの腹直筋鞘採取は、レシピエントの腹壁再建に有用であった。小腸移植患者において、手術時の一期的腹壁閉鎖を目指す戦略は不可避であり、今後の課題として、腹壁移植の必要性についても議論が必要である。</p>

    DOI: 10.11386/jst.59.supplement_s385_1

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  • Extreme resection for advanced hepatoblastoma in liver transplant era

    Matsuura Toshiharu, Maeda Shohei, Kajihara Keisuke, Uchida Yasuyuki, Toriigahara Yukihiro, Maniwa Junnosuke, Takahashi Yoshiaki, Kawakubo Naonori, Tajiri Tatsuro

    The Japanese Journal of Pediatric Hematology / Oncology   61 ( 2 )   144 - 147   2024   ISSN:2187011X eISSN:21895384

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    Language:Japanese   Publisher:The Japanese Society of Pediatric Hematology / Oncology  

    <p>In April 2008, liver transplantation (LT) for hepatoblastoma became covered under the Japanese medical insurance. Unresectable hepatoblastoma is considered an indication for LT; however, identifying “unresectable” hepatoblastoma is often difficult. Generally, unresectable tumors are those in cases categorized into post-treatment extent of disease grouping system POST-TEXT IV or III P+, V+. However, there are cases in which it is difficult to determine the resectability by preoperative imaging; although the tumor is considered resectable, a final surgical decision should be made at a facility capable of LT. Previously, it was safe to prioritize LT in cases of doubtful resectability owing to reports of extremely poor post-transplantation outcomes in salvage LT for reasons, such as recurrence after hepatectomy. Recently, there have been reports, including those from Japan, that the outcomes of salvage LT are good, and if the risk of long-term complications after LT is considered, challenging liver resection is reevaluated in this LT era. This article outlines the potential of atypical extreme hepatectomy using techniques used in transplant surgery, such as vascular reconstruction and organ preservation, and the surgical approach in cases with insufficient residual liver volume.</p>

    DOI: 10.11412/jspho.61.144

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  • 小腸移植後患者の長期生存へ向けた課題

    Maeda Shohei, Uchida Yasuyuki, Takahashi Yoshiaki, Kawakubo Naonori, Yoshimaru Koichiro, Nagata Kouji, Tajiri Tatsuro

    Japanese Journal of Transplantation   59 ( Supplement )   s221_1 - s221_1   2024   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:The Japan Society for Transplantation  

    <p>【背景】 本邦での小腸移植後短期成績は改善してきているものの長期成績については未だ満足できるものではない。小腸移植後患者の長期生存を得るための課題について、当科での経験症例を通して検討する。【当科症例】 これまでに当科で小腸移植を施行した症例は5例、移植時年齢は平均24.6歳(9-36歳)で、全例が脳死小腸移植である。原疾患はHirschsprung病類縁疾患3例、短腸症1例、MYO5B遺伝子異常1例で、1例に異時性肝小腸移植(肝は生体ドナー)を施行した。患者生存は3/5例(60%)、グラフト生着は2/5例(40%)である。2例の死亡原因は拒絶治療後の感染症、COVID-19感染を契機とした腎不全であった。生存例3例のうち、1例はPTLDのコントロールが付かずグラフト摘出を余儀なくされたが生存中である。一方で、グラフト生着している2例では、移植前に比べて栄養状態や患者QOLが劇的に改善しており、グラフト生着例においては小腸移植医療の素晴らしさを感じることができている。2例ともストーマは未だ閉鎖しておらず、定期的内視鏡を継続している。【結語】 小腸移植により腸管不全患者のQOLは劇的に改善する可能性があるが、長期的生存を得るためには、将来的な腎機能やPTLD・感染制御への配慮が鍵となる。小腸移植後免疫抑制療法について、長期成績向上のためのより適切なプロトコールを再検討する必要がある。</p>

    DOI: 10.11386/jst.59.supplement_s221_1

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  • 小児肝移植における腹壁閉鎖困難例の検討

    Maeda Shohei, Uchida Yasuyuki, Yoshimaru Koichiro, Matsuura Toshiharu, Tajiri Tatsuro

    Japanese Journal of Transplantation   59 ( Supplement )   s339_3 - s339_3   2024   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:The Japan Society for Transplantation  

    <p>【はじめに】乳幼児例の肝移植はグラフトが大きく、腹腔内に還納することでグラフトの血流障害や腹部コンパートメント症候群を起こすことがある。今回、当科の腹壁閉鎖困難例を検討した。【対象と方法】現在までに肝移植を施行した乳児例57例を対象とした。腹壁閉鎖困難例18例と腹壁閉鎖可能例39例を後方視的に比較検討した。腹壁閉鎖困難例はゴアテックスシートを用いて閉腹した。【結果】腹壁閉鎖困難例は閉鎖可能例と比較して、性別、移植時月齢に有意差は認めなかったが、有意に体重が小さかった(5,723 vs 6,425g)。グラフト重量、GRWR、GV/SLVはそれぞれ175 vs 202.5g, 3.03 vs 3.07%, 81.8 vs 86.3%と両群間に有意差は認めなかった。グラフトの種類は、減寸グラフトの割合が腹壁閉鎖困難例で有意に多かった(61 vs 26%)。血管合併症は腹壁閉鎖困難例で1例(5.6%)、閉鎖可能例で5例(8.8%)認め、再手術を要したが、有意差はなかった。ゴアテックスは中央値3カ月で摘出されており、全例腹壁閉鎖可能であった。手術時間は中央値130分であり、摘出までの期間が1カ月以内の症例は癒着が比較的軽度で、手術時間も短い傾向にあった。【結語】減寸グラフトを要する低体重児は腹壁困難の高リスクであった。全例摘出可能であったが、癒着例も多く、摘出時期に関しては更なる検討が必要である。</p>

    DOI: 10.11386/jst.59.supplement_s339_3

    CiNii Research

  • 小児の先天性胆道拡張症患者の早期・晩期成績(Early and late outcomes of congenital biliary dilatation in pediatric patients)

    Takahashi Yoshiaki, Kobayashi Takashi, Kinoshita Yoshiaki, Arai Yuhki, Ohyama Toshiyuki, Yokota Naoki, Sugai Yu, Takano Shoichi

    Pediatrics International   66 ( 1 )   ped.15712 - ped.15712   2024   ISSN:1328-8067

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    先天性胆道拡張症(CBD)の小児患者へ手術を施行した、過去40年間にわたる自験例の成績を調査した。1965~2021年に当施設でCBD手術を施行した患者94名のうち、経過観察が行えた59名(女性66.1%)を解析した。初回根治術時の月齢の中央値は37ヵ月、範囲は0~244ヵ月であった。胆道再建の術式としては、54名(91.5%)で肝管空腸吻合術が行われていた。早期合併症は7名で10件発生しており、その内訳は、手術部位感染、胆汁漏、イレウスが3件ずつ、胆管閉塞と腸重積が1件ずつであった。晩期合併症は9名で12件発生し、イレウス、吻合部狭窄、肝内結石が3件ずつ、異時性胆道癌が2件、膵石が1件、であった。肝内結石の患者3名では、内視鏡的アプローチに不応であったため肝切除術が行われていた。異時性胆道癌の2名は、最後の手術からそれぞれ34年後と13年後に同癌を発症し、最終的にこの癌のため死亡していた。この死亡例を除いた57名のうち、術後、長期にわたり定期的に経過観察検査を受けていた患者は35名(61.4%)のみであった。最後の経過観察時に20歳を超えていた女性患者は24名おり、そのうち結婚していた11名(45.8%)の全員が出産していた。

  • 先天性胆道拡張症術後の小児肝管空腸吻合部狭窄に対する新規アプ ローチ法

    髙橋 良彰, 松浦 俊治, 藤森 尚, 吉丸 耕一朗, 前田 翔平, 内田 康幸, 田尻 達郎

    Annual Meeting of Japanese Study Group on Pancreaticobiliary Maljunction   47 ( 0 )   36 - 37   2024   ISSN:18834116 eISSN:24353140

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    DOI: 10.34410/jspbm.47.0_36

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  • The Volume of Intestinal Decompression can Predict the Necessity of Surgical Intervention for Adhesive Small Bowel Obstruction

    Kono, J; Yoshimaru, K; Kondo, T; Takahashi, Y; Toriigahara, Y; Fukuta, A; Obata, S; Kawakubo, N; Nagata, K; Matsuura, T; Tajiri, T

    JOURNAL OF PEDIATRIC SURGERY   58 ( 7 )   1252 - 1257   2023.7   ISSN:0022-3468 eISSN:1531-5037

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    Background: There is no standard timing for switching to surgical management for children with adhesive small bowel obstruction (ASBO) who initially receive conservative treatment. We hypothesized that an increased gastrointestinal drainage volume may indicate the need for surgical intervention. Methods: The study population included 150 episodes in the patients less than 20 years of age who received treatment for ASBO in our department from January 2008 to August 2019. Patients were divided into two groups: the successful conservative treatment group (CT) and the eventual surgical treatment group (ST). Following the analysis of all episodes (Study 1), we limited our analysis to only first ASBO episodes (Study 2). We retrospectively reviewed their medical records. Results: There were statistically significant differences in the volume on the 2nd day in both Study 1 (9.1 ml/kg vs. 18.7 ml/kg; p < 0.01) and study 2 (8.1 ml/kg vs. 19.7 ml/kg; p < 0.01). The cut-off value was the same for both Study 1 and Study 2 (11.7 ml/kg). Conclusions: The gastrointestinal drainage volume on the 2nd day in ST was significantly larger than that in CT. Accordingly, we considered that the drainage volume may predict eventual surgical intervention for children with ASBO who initially receive conservative treatment. Level of evidence: Level IV.

    DOI: 10.1016/j.jpedsurg.2023.01.052

    Web of Science

    Scopus

    PubMed

  • Hirschsprung病の思春期女性に出現した卵管留膿症に対して経腟超音波下ドレナージを施行した稀な症例(A rare case of pyosalpinx in adolescent girl with Hirschsprung's disease who underwent transvaginal ultrasound-guided drainage)

    Sugai Yu, Kinoshita Yoshiaki, Kobayashi Takashi, Takahashi Yoshiaki, Arai Yuhki, Ohyama Toshiyuki, Yokota Naoki, Takano Shoichi, Kobayashi Akiko

    Surgical Case Reports   9   1 of 6 - 6 of 6   2023.5

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    Language:English   Publisher:(一社)日本外科学会  

    症例は12歳女児。下腹部痛を主訴とした。Hirschsprung病の既往があり、2歳時までに5回の開腹術を受けた。身長は159cm、体重は83kg、BMIは32.8kg/m2であった。10歳で初潮となり、月経周期は正常であった。頻回の便失禁に対して便漏れパッドを装着していた。受診時の体温は38.5℃で、頻脈と頻呼吸を認めた。臨床検査で白血球数は21250/μL、C反応性蛋白は54.77mg/dL、尿素窒素は27IU/L、クレアチニンは1.21mg/dLであった。腹部CTで骨盤および腹腔内に多嚢胞性腫瘤を認めた。MRIおよび経腟超音波検査の所見を合わせて腹腔内膿瘍を伴う卵管留膿症と診断した。外科的治療を要したが、これまでの手術歴および高度肥満を考慮して開腹術は高リスクと判断し、経腟超音波ガイド下にドレナージを施行した。ドレーン排液は膿性で、排液量は370mLであった。細菌培養で嫌気性菌であるBacteroides fragilis、Fusobacterium nucleatum、大腸菌が検出された。抗生剤を投与し、52日後に退院となった。1ヵ月後のCTで症状の再発はみられなかった。

  • Oncologic emergencyを呈した前縦隔腫瘍の生検困難例への経験-苦慮した1例より-

    高橋 良彰, 木下 義晶, 小林 隆

    日本小児血液・がん学会雑誌   60   61 - 64   2023

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  • Immunohistochemistry reveals an increased number of ganglion cells in the normal-size plexus, as a pathological feature of immaturity of ganglia

    Yoshimaru K., Miyoshi K., Kinoshita Y., Obata S., Yanagi Y., Takahashi Y., Kajihara K., Irie K., Uchida Y., Toriigahara Y., Kawano Y., Kohashi K., Yoshioka T., Nakazawa A., Matsuura T., Oda Y., Tajiri T., Taguchi T.

    Comparative Clinical Pathology   31 ( 6 )   951 - 957   2022.12   ISSN:16185641

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    Publisher:Comparative Clinical Pathology  

    Immaturity of ganglia (IG), is a rare entity of an allied disorder of Hirschsprung’s disease. We reviewed our IG cases to provide further pathological insight into IG. The clinical data and pathological findings of IG cases in our department from 2011 to 2020 were examined. Hematoxylin and eosin (HE) staining and immunostaining for HuC/D, BCL-2, SOX10, and CD56 were performed on full-thickness specimens. Sufficient clinical data and pathological specimens were available in five cases during the study period. The patient profiles were as follows: four term infants and one preterm infant with initial symptoms of abdominal distension or vomiting; all cases underwent ileostomy at a median age of 2 days and stoma closure at a median age of 5 months. Although the interpretation of HE staining was difficult, immunostaining for HuC/D and SOX10 clearly distinguished ganglion cells from glial cells. The number of ganglion cells in the IG group was significantly greater than that in the control group (p < 0.05), while the number of enteric glial cells and total area of the myenteric nerve plexus did not differ. The finding of the increased number of ganglion cells in a normal-size myenteric plexus is a novel feature of IG that contributes to its accurate diagnosis.

    DOI: 10.1007/s00580-022-03390-w

    Scopus

  • 絞扼性腸閉塞後の短腸症候群に併発した好酸球性消化管障害の稀な症例(A rare case of eosinophilic gastrointestinal disorders with short bowel syndrome after strangulated bowel obstruction)

    Arai Yuhki, Kinoshita Yoshiaki, Kobayashi Takashi, Takahashi Yoshiaki, Ohyama Toshiyuki, Yokota Naoki, Sugai Yu, Takano Shoichi, Hamasaki Yu, Kaneko Utako, Kanada Satoshi

    Surgical Case Reports   8   1 of 6 - 6 of 6   2022.9

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    Language:English   Publisher:(一社)日本外科学会  

    症例は5歳男児。腸間膜裂孔ヘルニアが原因の絞扼性腸閉塞を発症して近医を受診し、壊死した腸管を340cmの長さにわたって切除された。残存腸管の長さは51cmであった。術後合併症はみられず全身状態は安定していたが、術後19日目になって血性便が現れた。大腸内視鏡検査を行ったところ結腸粘膜にびまん性の発赤と浮腫が観察され、その病理所見としては中等度の慢性炎症性細胞浸潤が示された。特に好酸球の数が多く、1強拡大視野あたり20個を超えていた。血算でも好酸球が30%を上回っていた。以上から短腸症候群に併発した好酸球性消化管障害(EGID)が疑われた。経腸栄養法を含む栄養療法を開始されたが血性便の消退と増悪を繰り返し、長期にわたる経腸栄養法が原因で肝機能障害も出現した。そのため、前記の手術から5ヵ月後にEGID治療目的で当院へ転院となった。転院後6日目からプレドニゾロン(PSL)を初期用量1.4mg/kg/日で開始したところ血性便は消退した。病理学的にも炎症細胞浸潤と好酸球増多が改善し、転院後92日目にPSLを継続している状態で退院した。退院から5ヵ月後にPSLを終了し、その終了からさらに7ヵ月後においても症状の再発はみられなかった。

  • 新生児集中治療室における難治性乳び胸の管理 22年間の経験(Management of refractory chylothorax in the neonatal intensive care unit: A 22-year experience)

    Takahashi Yoshiaki, Kinoshita Yoshiaki, Kobayashi Takashi, Arai Yuhki, Ohyama Toshiyuki, Yokota Naoki, Saito Koichi, Sugai Yu, Takano Shoichi

    Pediatrics International   64 ( 1 )   ped.15043 - ped.15043   2022   ISSN:1328-8067

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    新生児集中治療室(NICU)で乳び胸と診断された患児、特に胸膜癒着術、胸管結紮術、リンパ管静脈吻合術などの外科的治療に至った難治性気胸の新生児の臨床経過を評価した。1998~2020年に当施設NICUで乳び胸に対して治療を受けた新生児28例(男児14例、女児14例、発症時平均8.9±13.9日齢)を対象に、臨床的特徴と転帰を後ろ向きに検討した。18例が先天性乳び胸と診断され、10例は術後に乳び胸を発症した。8例が染色体異常と診断された。6例が胸膜癒着術、胸管結紮術、リンパ管静脈吻合術などの外科的治療を受けた。外科的治療群(6例)は非外科的治療群(22例)よりも1日の最大胸水量が有意に多かった。1日の最大胸水量/体重比の受信者動作特性分析において、カットオフ値を101mL/kgとした場合の曲線下面積は0.889であり、感度は0.8333、特異度は0.8095であった(P=0.0059)。

  • Nutritional management after isolated intestinal transplantation for chronic idiopathic intestinal pseudo-obstruction

    UCHIDA Yasuyuki, KAJIHARA Keisuke, KAWANO Yuki, TORIIGAHARA Yukihiro, SHIRAI Takeshi, TAKAHASHI Yoshiaki, YOSHIMARU Koichiro, MATSUURA Toshiharu, TAJIRI Tatsuro

    Japanese Journal of Transplantation   57 ( 1 )   125 - 131   2022   ISSN:05787947 eISSN:21880034

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    Language:Japanese   Publisher:The Japan Society for Transplantation  

    <p>Intestinal failure is a complicated medical condition resulting in the loss of absorptive area or in severe gastrointestinal bacterial overgrowth. Prolonged use of parenteral nutrition (PN) puts patients at risk of multiple complications, including catheter-related bloodstream infection (CRBSI), intestinal failure-associated liver disease (IFALD), and renal impairment. Intestinal rehabilitation programs (IRPs) have recently been recognized as playing a significant role in outcome improvement, care coordination, and complication prevention. We herein report an adult case of chronic idiopathic intestinal pseudo-obstruction (CIIP) that underwent isolated intestinal transplantation (ITx) from a deceased donor. Because the loss of central vascular access was his indication for ITx, a catheter for perioperative management was inserted in the azygous vein via intercostal veins punctured under ultrasound guidance. A total of 255 cm of small intestine with a 10-cm ascending colon graft was transplanted, and the proximal side was anastomosed to the native duodenum. Because the native gastro-duodenum dysmotility remained even after isolated ITx for CIIP, decompression of the native gastroduodenum with a gastro-jejunum tube via gastrostomy and feeding via tube enterostomy at the graft intestine were needed during the first four to five months after ITx. However, such management was effective in achieving full enteral feeding at an early stage with stable immunosuppressive therapy. Intervention with an IRP for management before ITx helped prevent CRBSIs and facilitated his continuing parenteral nutrition until ITx. Multidisciplinary collaboration on an IRP team is mandatory for the perioperative management of ITx patients.</p>

    DOI: 10.11386/jst.57.1_125

    CiNii Research

  • The experiences of interval appendectomy for inflammatory appendiceal mass Reviewed International journal

    Yoshiaki Takahashi, Satoshi Obata, Toshiharu Matsuura, Yuhki Kawano, Yusuke Yanagi, Koichiro Yoshimaru, Tomoko Izaki, Tomoaki Taguchi

    Pediatrics International   54 ( 12 )   88 - 93   2021.1

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  • Comparison of biliary atresia with and without intracranial hemorrhage Invited Reviewed International journal

    Yoshiaki Takahashi, Toshiharu Matsuura, Koichiro Yoshimaru, Yusuke Yanagi, Makoto Hayashida, Tomoaki Taguchi

    2019.12

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  • Therapeutic potential of spheroids of stem cells from human exfoliated deciduous teeth for chronic liver fibrosis and hemophilia A Invited Reviewed International journal

    Yoshitaki Takahashi, Tatih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Haruyoshi Yamaza, Kosuke Kirino, Koichiro Yoshimaru, Toshiharu Matsuura, Tomoaki Taguchi

    2018.11

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  • Liver graft-to-spleen volume ratio as a useful predictive factor of the early graft function in children and young adults transplanted for biliary atresia: a retrospective study Invited Reviewed International journal

    Yoshiaki Takahashi, Toshiharu Matsuura, Koichiro Yoshimaru, Yusuke Yanagi, Makoto Hayashida, Tomoaki Taguchi

    2018.6

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  • The role of splenectomy before liver transplantation in biliary atresia patients Invited Reviewed International journal

    Yoshiaki Takahashi, Toshiharu Matsuura, Yusuke Yanagi, Koichiro Yoshimaru, Tomoaki Taguchi

    2016.12

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Presentations

  • 胆道閉鎖症に対する移植前脾臓摘出術後の長期予後

    髙橋良彰、松浦俊治、前田翔平、内田康幸、梶原啓資、鳥井ケ原幸博、福田篤久、川久保尚徳、永田公二、田尻達郎

    第37回日本小児脾臓・門脈研究会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都府立医科大学図書館ホール   Country:Japan  

  • 異時性肝小腸移植におけるグラフト肝機能および組織学的所見の推移

    髙橋良彰、松浦俊治、前田翔平、内田康幸、梶原啓資、鳥井ケ原幸博、濵田洋、日野祐子、福原雅弘、玉城昭彦、永田公二、田尻達郎

    第48回九州代謝栄養研究会  2024.3 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米大学筑水会館   Country:Japan  

  • S状結腸過長症に対して外科治療を施行した慢性便秘症の検討 Invited

    髙橋良彰、木下義晶、小林 隆、荒井勇樹、大山俊之、斎藤浩一

    第50回日本小児栄養消化器肝臓学会学術集会  2023.10 

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    Event date: 2023.10

    Language:Japanese  

    Venue:江陽グランドホテル   Country:Japan  

  • 管理に難渋している短腸症候群患児の腸内細菌叢の変化

    髙橋良彰、木下義晶、小林 隆、荒井勇樹、大山俊之、斎藤浩一

    第52回日本小児外科代謝研究会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Therapeutic potential of spheroids of Stem Cells from Human Exfoliated Deciduous Teeth to chronic liver fibrosis and hemophilia A International conference

    Takahashi Y, Yamaza T, Yuniartha R, Kirino K, Yoshimaru K, Matsuura T, Taguchi T

    2019.9 

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    Event date: 2019.9

    Language:Japanese  

    Country:Japan  

  • Effective spheroids transplantation of SHED-derived hepatocytes-like cells in liver fibrosis mice

    Takahashi Y, Yuniartha R, Yamaza T, Kirino K, Yanagi Y, Matsuura T, Taguchi T

    2018.10 

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    Event date: 2018.10

    Language:Japanese  

    Country:Italy  

  • Biliary lineage of Hepatocyte-like cells derived from SHED (Stem Cells from Human Exfoliated Deciduous Teeth) in liver fibrosis mice International conference

    Takahashi Y, Yuniartha R, Yamaza T, Kirino K, Yanagi Y, Matsuura T, Taguchi T

    2018.10 

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    Event date: 2018.10

    Language:Japanese  

    Country:Japan  

  • 頸部から縦隔に及ぶ巨大な脂肪芽腫の1例(A case of a huge cervical and mediastinal lipoblastoma)

    Arai Yuhki, Hamasaki Yu, Sugai Yu, Ohyama Toshiyuki, Takahashi Yoshiaki, Kobayashi Takashi, Takahashi Takeshi, Sugimoto Ai, Arizumi Takashi, Kinoshita Yoshiaki

    日本小児血液・がん学会雑誌  2023.11  (一社)日本小児血液・がん学会

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  • ヒト脱落歯由来の幹細胞は重度の蠕動低下を緩和する(Stem cells derived from human exfoliated deciduous teeth ameliorate severe hypoperistalsis)

    Yoshimaru Koichiro, Yamaza Takayoshi, Kajioka Shunichi, Maeda Shohei, Uchida Yasuyuki, Takahashi Yoshiaki, Matsuura Toshiharu, Taguchi Tomoaki, Tajiri Tatsuro

    日本小児栄養消化器肝臓学会雑誌  2024.10  (一社)日本小児栄養消化器肝臓学会

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MISC

Professional Memberships

  • 日本小児外科学会

  • 日本外科学会

  • 日本小児血液・がん学会

  • 日本移植学会

  • 日本周産期・新生児医学会

  • Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition

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Committee Memberships

  • 日本小児外科学会   Councilor   Domestic

    2023.10   

Research Projects

  • 早期臨床応用に向けた腸管グリアに着目した腸管神経節細胞僅少症に対する再生医療開発

    Grant number:25K11866  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    吉丸 耕一朗, 田尻 達郎, 松浦 俊治, 高橋 良彰, 前田 翔平, 田口 智章, 山座 孝義, 園田 聡一朗, 小田 義直, 岩崎 健, 福本 敏, 梶岡 俊一

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    Grant type:Scientific research funding

    腸管神経節細胞僅少症(HYPO) は、「壁内神経節細胞の減少」という異常により腸管蠕動不全を呈し、繰り返す姑息的手術と終生の静脈栄養を要す厚労省指定難病である。研究代表者は、健常児由来のヒト乳歯歯髄幹細胞(healthy SHED)の静注移植によるHYPOモデルマウスの腸管蠕動の改善に世界に先駆けて成功したが、さらにHYPO患者に対するSHEDの早期臨床応用を目指し、healthy SHEDとHYPO患児由来SHED(HYPO SHED)のいずれが最適であるかを検討したいと考え、グリア細胞の機能に着目しつつ、HYPO SHED移植の有効性と安全性を比較検証することを目的としている。

    CiNii Research

  • 移植肝の生物学的長寿を目指した老化細胞解析を基盤とする包括的研究

    Grant number:25K11842  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    松浦 俊治, 田尻 達郎, 吉丸 耕一朗, 高橋 良彰, 前田 翔平

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    Grant type:Scientific research funding

    われわれは、これまでに肝細胞における細胞死や細胞初期化に関する研究を行ってきた背景もあり、今回、肝組織中の老化細胞に着目することで、グラフト肝の“老化状態”の把握とその制御に関連する因子について解析することを着想した。宿主と異なる年齢の臓器を体内に持つという臓器移植後ならではの特殊な環境のもとで、老化細胞に着目した今回の研究は独自性を有しており、将来的には、いつまでも若々しく健康なグラフト肝を維持するため、老化細胞制御というこれまでにない全く新しいアプローチ法によって、今後、グラフト肝の長期生存を目指した肝移植医療における大きなパラダイムシフトに繋がる可能性を秘めている。

    CiNii Research

  • 腸管不全関連肝障害(IFALD)における新規細胞死フェロトーシス機序の解明

    Grant number:22K08754  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    松浦 俊治, 田尻 達郎, 柳 佑典, 河野 雄紀, 高橋 良彰

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    Grant type:Scientific research funding

    短腸症の生命予後を規定する病態として腸管不全関連肝障害(IFALD)が知られている。細胞の恒常性維持や細胞老化に関係する細胞内機構であるオートファジーの破綻が、肝組織の再生や修復に大きく関わっている。しかしながら、こうして障害された肝細胞におけるオートファジー機構の変化が、如何に直接的に肝細胞の細胞死に繋がっているかはいまだ十分に解明されていない。本研究では、鉄依存性新規細胞死フェロトーシスに着眼し、短腸症によるIFALDが不可逆性を獲得して進展する病態に如何に関わっているかについて解明することを目的とする。

    CiNii Research

  • 小児良性固形腫瘍に対する免疫学的糖鎖解析法を用いた診断システムの開発

    Grant number:21K08661  2021.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    木下 義晶, 小林 隆, 高橋 良彰

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    Grant type:Scientific research funding

    小児の固形腫瘍のうち血管腫、リンパ管種、良性の奇形腫(以下、胚細胞腫瘍)などの良性腫瘍は時として鑑別診断が難しく、その臨床像も多彩で、症例によっては巨大で重要臓器や血管をまきこみ外科的治療が困難である。特異的な腫瘍マーカーはなく、診断は画像診断に頼らざるをえない。正確な診断がつかなければ治療の導入が遅れ、良性腫瘍とはいっても時として予期せぬ転帰をたどることがある。
    本研究ではそれぞれの小児良性固形腫瘍の発生起源として候補に挙がっている遺伝子産物である糖鎖抗原蛋白を血清学的に診断可能にする免疫電気泳動法と質量分析法を用いた非侵襲的新規簡易診断システムの開発を目的とする。

    CiNii Research

  • 致死的合併症であるIFALD予防を網羅した短腸症候群に対する新規細胞治療の確立

    Grant number:21K08639  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • in vivoイメージングを用いた高解像度画像システムによる拒絶反応診断

    2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • オートファジーからみた腸管不全関連肝障害(IFALD)の病態解明とその制御

    Grant number:19K09074 

    松浦 俊治, 田口 智章, 吉丸 耕一朗, 高橋 良彰

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    Grant type:Scientific research funding

    短腸症の予後を規定する病態として腸管不全関連肝障害(IFALD)が知られている。長期静脈栄養に伴う肝臓での脂質代謝異常を背景に腸内細菌叢の変化や胆汁輸送機構の障害など様々な機序が報告されているが、未だ根本的な発症予防と治療に結びついていない。オートファジーは細胞の恒常性維持や細胞老化に関係する細胞内機構であり、組織の再生や修復に大きくかかわっている。障害された肝細胞におけるオートファジー機構の変化が、IFALDの病態進行にいかに関わっているかについての報告はない。今回の研究において、IFALDに関与するオートファジー関連マーカーを同定することでIFLAD進行例に対する標的治療の開発を目指す。

    CiNii Research

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Educational Activities

  • 九州大学病院小児外科において、学生および研修生に対して、病態や、診断、治療に関して指導を行う。
    ベッドサイドだけではなく、講義も行う。

Class subject

  • 受胎・成長・発達

    2024.4 - 2024.9   First semester

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Pediatric Surgery

Clinician qualification

  • Specialist

    Japan Surgical Society(JSS)

  • Specialist

    The Japanese Society of Pediatric Surgeons(JSPS)

  • Certifying physician

    Japan Society of Perinatal and Neonatal Medicine

  • Certifying physician

    日本小児栄養消化器肝臓学会

Year of medical license acquisition

  • 2009