Updated on 2024/07/28

Information

 

写真a

 
OHARA TOMOYUKI
 
Organization
Kyushu University Hospital Neuro-Psychiatry Lecturer
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Lecturer
Tel
0926425627
Profile
研究活動:福岡県久山町における疫学調査(久山町研究)において、うつ病、または認知症と生活習慣病との関係についての検討。アルツハイマー病を主とした生活習慣病関連遺伝子の探索。臨床・遺伝子情報をもとにした、生活習慣病と環境要因の相互作用についての解析。 教育活動:学生、研修医、研究生に対し、老年精神医学の講義や研究の指導に従事。 診療活動:外来および病棟において、主に老年期精神障害の診断と治療に従事。
External link

Degree

  • M.D., Ph.D

Research History

  • 平成17年5月 福岡県立精神医療センター 太宰府病院 平成18年4月 佐賀県立病院好生館 精神科

    平成17年5月 福岡県立精神医療センター 太宰府病院 平成18年4月 佐賀県立病院好生館 精神科

Research Interests・Research Keywords

  • Research theme:Epidemiological study of the incidence, mortality, and risk factors of dementia or depression in Hisayama Town. Analyses of environmental and genetic predisposition to lifestyle-related disorders in the Hisayama study.

    Keyword:Hisayama Study, Dementia, Alzheimer's disease, Genetics

    Research period: 2008.4

Awards

  • 精神医学奨励賞

    2012.5   日本精神神経学会   Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, Kanba S, Kiyohara Y: Glucose tolerance status and risk of dementia in the community: the Hisayama Study. Neurology. 77(12): 1126-1134, 2011. Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y: Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study. J Am Geriatr Soc. 59(6): 1074-79, 2011.

Papers

  • Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study Reviewed

    2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    Aims/Introduction: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A1c and the GA : HbA1cratio – with global brain and hippocampal atrophy in a general elderly Japanese population. Materials and Methods: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. Results: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA1c ratio levels (all P for trend < 0.05), but not with higher HbA1c levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA1c ratio levels, but not HbA1c, were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. Conclusions: The present study suggests that higher serum GA and higher GA : HbA1c ratio are significantly associated with global brain and hippocampal atrophy.

    DOI: 10.1111/jdi.13220

  • Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia The Hisayama Study Reviewed

    Tomoyuki Ohara, Jun Hata, Masashi Tanaka, Takanori Honda, Hajime Yamakage, Daigo Yoshida, Takayuki Inoue, Yoichiro Hirakawa, Toru Kusakabe, Mao Shibata, Tadashi Teraoka, Takanari Kitazono, Shigenobu Kanba, Noriko Satoh-Asahara, Toshiharu Ninomiya

    Annals of Neurology   85 ( 1 )   47 - 58   2019.1

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    DOI: 10.1002/ana.25385

  • Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community Reviewed

    Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya

    Journal of the American Geriatrics Society   66 ( 10 )   1911 - 1918   2018.10

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    DOI: 10.1111/jgs.15446

  • Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population The Hisayama Study Reviewed

    Emi Oishi, Tomoyuki Ohara, Satoko Sakata, Masayo Fukuhara, Jun Hata, Daigo Yoshida, Mao Shibata, Toshio Ohtsubo, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Circulation   136 ( 6 )   516 - 525   2017.8

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    DOI: 10.1161/CIRCULATIONAHA.116.025667

  • The changing prevalence and incidence of dementia over time-current evidence Reviewed

    Nature Reviews Neurology   13 ( 6 )   327 - 339   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nrneurol.2017.63

  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community Reviewed

    Tomoyuki Ohara, Jun Hata, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Toru Iwaki, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara, Toshiharu Ninomiya

    Neurology   88 ( 20 )   1925 - 1932   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000003932

  • Midlife and late-life smoking and risk of dementia in the community The Hisayama study Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya, Jun Hata, Mio Ozawa, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Toru Iwaki, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara

    Journal of the American Geriatrics Society   63 ( 11 )   2332 - 2339   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.13794

  • Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya, Yoichiro Hirakawa, Kyota Ashikawa, Akira Monji, Yutaka Kiyohara, Shigenobu Kanba, Michiaki Kubo

    Psychiatric Genetics   22 ( 6 )   290 - 293   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/YPG.0b013e3283586215

  • Glucose tolerance status and risk of dementia in the community The Hisayama Study Reviewed

    Tomoyuki Ohara, Y. Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Jun Hata, Toru Iwaki, Shigenobu Kanba, Y. Kiyohara

    Neurology   77 ( 12 )   1126 - 1134   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0b013e31822f0435

  • Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese The hisayama study Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya, Michiaki Kubo, Yoichiro Hirakawa, Yasufumi Doi, Jun Hata, Toru Iwaki, Shigenobu Kanba, Yutaka Kiyohara

    Journal of the American Geriatrics Society   59 ( 6 )   1074 - 1079   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1532-5415.2011.03405.x

  • Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia: The JPSC-AD Study. International journal

    Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Neurology   2023.7

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  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study. International journal

    Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya

    Psychiatry and clinical neurosciences   77 ( 6 )   330 - 337   2023.6

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    DOI: 10.1111/pcn.13533

  • CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia. International journal

    Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Kidney medicine   5 ( 3 )   100593 - 100593   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.xkme.2022.100593

  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study. International journal

    Takahiro Tajimi, Yoshihiko Furuta, Naoki Hirabayashi, Takanori Honda, Jun Hata, Tomoyuki Ohara, Mao Shibata, Tomohiro Nakao, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya

    Archives of gerontology and geriatrics   106   104883 - 104883   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.archger.2022.104883

  • Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study

    Yasumi Kimura, Daigo Yoshida, Tomoyuki Ohara, Jun Hata, Takanori Honda, Yoichiro Hirakawa, Mao Shibata, Emi Oishi, Satoko Sakata, Yoshihiko Furuta, Sanmei Chen, Kazuhiro Uchida, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya

    BMC Geriatrics   22 ( 1 )   2022.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12877-022-02939-2

  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community. International journal

    Akane Mihara, Tomoyuki Ohara, Jun Hata, Sanmei Chen, Takanori Honda, Sonam Tamrakar, Akiko Isa, Dongmei Wang, Kuniyoshi Shimizu, Yoshinori Katakura, Koji Yonemoto, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya

    Scientific reports   12 ( 1 )   12427 - 12427   2022.7

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    DOI: 10.1038/s41598-022-16242-y

  • Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population: The Hisayama Study. International journal

    Emi Ueda, Naoki Hirabayashi, Tomoyuki Ohara, Jun Hata, Takanori Honda, Kohta Fujiwara, Yoshihiko Furuta, Mao Shibata, Sawako Hashimoto, Shun Nakamura, Taro Nakazawa, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya, Koh-Hei Sonoda

    Ophthalmology science   2 ( 2 )   100157 - 100157   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.xops.2022.100157

  • Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study. International journal

    Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Tomoyuki Ohara, Mao Shibata, Yoichiro Hirakawa, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya

    Diabetes care   45 ( 6 )   1364 - 1371   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc21-1911

  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community. International journal

    Tomoyuki Ohara, Jun Hata, Masashi Tanaka, Takanori Honda, Hajime Yamakage, Takayuki Inoue, Yoichiro Hirakawa, Toru Kusakabe, Mao Shibata, Takanari Kitazono, Tomohiro Nakao, Noriko Satoh-Asahara, Toshiharu Ninomiya

    Journal of the American Geriatrics Society   70 ( 4 )   1147 - 1156   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.17634

  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study. International journal

    Masako Asada, Mao Shibata, Naoki Hirabayashi, Tomoyuki Ohara, Yoshihiko Furuta, Taro Nakazawa, Takanori Honda, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya

    Pain   163 ( 11 )   2185 - 2193   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/j.pain.0000000000002612

  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study. Invited Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

    J Neurol Neurosurg Psychiatry   93 ( 3 )   263 - 271   2022.3

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  • Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study. International journal

    32 ( 1 )   e13014   2022.1

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    Previous studies have revealed risk for cognitive impairment in cardiovascular diseases. We investigated the relationship between degenerative changes of the brain and heart, with reference to Alzheimer's disease (AD) pathologies, cardiac transthyretin amyloid (ATTR) deposition, and cardiac fibrosis. A total of 240 consecutive autopsy cases of a Japanese population-based study were examined. β amyloid (Aβ) of senile plaques, phosphorylated tau protein of neurofibrillary tangles, and ATTR in the hearts were immunohistochemically detected and graded according to the NIH-AA guideline for AD pathology and as Tanskanen reported, respectively. Cerebral amyloid angiopathy (CAA) was graded according to the Vonsattel scale. Cardiac fibrosis was detected by picrosirius red staining, followed by image analysis. Cardiac ATTR deposition occurred after age 75 years and increased in an age-dependent manner. ATTR deposition was more common, and of higher grades, in the dementia cases. We subdivided the cases into two age groups: ≤90 years old (n = 173) and >90 years old (n = 67), which was the mean and median age at death of the AD cases. When adjusted for age and sex, TTR deposition grades correlated with Aβ phase score (A2-3), the Consortium to Establish a Registry for AD score (sparse to frequent), and high Braak stage (V-VI) only in those aged ≤90 years at death. No significant correlation was observed between the cardiac ATTR deposition and CAA stages, or between cardiac fibrosis and AD pathologies. Collectively, AD brain pathology correlated with cardiac TTR deposition among the older adults ≤90 years.

    DOI: 10.1111/bpa.13014

  • A Comparative Study of Site-Specific Distribution of Aging-Related Tau Astrogliopathy and Its Risk Factors Between Alzheimer Disease and Cognitive Healthy Brains: The Hisayama Study. International journal

    Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Hideomi Hamasaki, Sachiko Koyama, Hideko Noguchi, Akane Mihara, Taro Nakazawa, Jun Hata, Toshiharu Ninomiya, Toru Iwaki

    Journal of neuropathology and experimental neurology   81 ( 2 )   106 - 116   2022.1

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    DOI: 10.1093/jnen/nlab126

  • A comparative study of site-specific distribution of aging-related tau astrogliopathy and its risk factors between Alzheimer disease and cognitive healthy brains: the Hisayama Study. Invited Reviewed International journal

    Yagita K, Honda H, Ohara T, Hamasaki H, Koyama S, Noguchi H, Mihara A, Nakazawa T, Hata J, Ninomiya T, Iwaki T

    J Neuropathol Exp Neurol   81 ( 2 )   106 - 116   2022.1

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  • Diabetes mellitus, elevated hemoglobin A1c, and glycated albumin are associated with the presence of all-cause dementia and Alzheimer's disease: the JPSC-AD Study. Invited Reviewed International journal

    Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M

    J Alzheimers Dis   85 ( 1 )   235 - 247   2022.1

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  • Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: the Hisayama study Invited Reviewed International journal

    32 ( 1 )   e13014   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study

    Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya

    Journal of Neurology, Neurosurgery & Psychiatry   jnnp - 2021   2021.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2021-326611

  • Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. International journal

    Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Kunihiko Sakumi, Frank M LaFerla, Yusaku Nakabeppu

    Scientific reports   11 ( 1 )   18377 - 18377   2021.9

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    Language:English  

    DOI: 10.1038/s41598-021-97918-9

  • Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study. International journal

    Emi Oishi, Jun Hata, Takanori Honda, Satoko Sakata, Sanmei Chen, Yoichiro Hirakawa, Daigo Yoshida, Mao Shibata, Tomoyuki Ohara, Yoshihiko Furuta, Takanari Kitazono, Toshiharu Ninomiya

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 9 )   1221 - 1229   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-021-00673-7

  • 地域高齢住民における歩行速度と認知症発症および脳容積との関連 久山町研究

    多治見 昂洋, 古田 芳彦, 平林 直樹, 本田 貴紀, 秦 淳, 小原 知之, 柴田 舞欧, 中尾 智博, 北園 孝成, 中島 康晴, 二宮 利治

    日本整形外科学会雑誌   95 ( 8 )   S1723 - S1723   2021.8

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    Language:Japanese  

  • 地域高齢住民における歩行速度と認知症発症および脳容積との関連 久山町研究

    多治見 昂洋, 古田 芳彦, 平林 直樹, 本田 貴紀, 秦 淳, 小原 知之, 柴田 舞欧, 中尾 智博, 北園 孝成, 中島 康晴, 二宮 利治

    日本整形外科学会雑誌   95 ( 8 )   S1723 - S1723   2021.8

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    Language:Japanese  

  • Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study. Invited Reviewed International journal

    Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T

    Hypertens Res   14 ( 9 )   1221 - 1229   2021.5

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  • Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study. Invited Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T

    J Diabetes Investig   12 ( 10 )   1899 - 1907   2021.5

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  • Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study.

    Kimitaka Nakamura, Daigo Yoshida, Takanori Honda, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Yoshihiko Furuta, Hiro Kishimoto, Tomoyuki Ohara, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya

    Journal of epidemiology   31 ( 5 )   320 - 327   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20190289

  • Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study. International journal

    Tomoyuki Ohara, Daigo Yoshida, Jun Hata, Mao Shibata, Takanori Honda, Yoshihiko Furuta, Naoki Hirabayashi, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya

    Psychiatry and clinical neurosciences   75 ( 5 )   182 - 184   2021.5

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    Language:English  

    DOI: 10.1111/pcn.13204

  • High Serum Folate Concentrations Are Associated with Decreased Risk of Mortality among Japanese Adults. International journal

    Sanmei Chen, Takanori Honda, Jun Hata, Satoko Sakata, Yoshihiko Furuta, Daigo Yoshida, Mao Shibata, Tomoyuki Ohara, Yoichiro Hirakawa, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya

    The Journal of nutrition   151 ( 3 )   657 - 665   2021.3

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    DOI: 10.1093/jn/nxaa382

  • Midlife and late-life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study.

    Kimitaka Nakamura, Daigo Yoshida, Takanori Honda, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Yoshihiko Furuta, Hiro Kishimoto, Tomoyuki Ohara, Sanmei Chen, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya

    Journal of diabetes investigation   12 ( 10 )   1899 - 1907   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13550

  • Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study. International journal

    Takuya Nagata, Jun Hata, Satoko Sakata, Emi Oishi, Takanori Honda, Yoshihiko Furuta, Tomoyuki Ohara, Daigo Yoshida, Yoichiro Hirakawa, Mao Shibata, Tomomi Ide, Takanari Kitazono, Hiroyuki Tsutsui, Toshiharu Ninomiya

    International journal of cardiology   320   90 - 96   2020.12

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    DOI: 10.1016/j.ijcard.2020.06.018

  • Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study. International journal

    Mao Shibata, Tomoyuki Ohara, Masako Hosoi, Hata Jun, Daigo Yoshida, Naoki Hirabayashi, Yukiko Morisaki, Taro Nakazawa, Akane Mihara, Takuya Nagata, Emi Oishi, Kozo Anno, Nobuyuki Sudo, Toshiharu Ninomiya

    The journals of gerontology. Series B, Psychological sciences and social sciences   76 ( 9 )   1756 - 1766   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/geronb/gbaa196

  • Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). International journal

    Toshiharu Ninomiya, Shigeyuki Nakaji, Tetsuya Maeda, Masahito Yamada, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi, Tomoyuki Ohara, Jun Hata, Yoshihiro Kokubo, Kazuhiro Uchida, Yasuyuki Taki, Shuzo Kumagai, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yukihide Momozawa, Masato Akiyama, Michiaki Kubo, Manabu Ikeda, Shigenobu Kanba, Yutaka Kiyohara

    Environmental health and preventive medicine   25 ( 1 )   64 - 64   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-020-00903-3

  • Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia. International journal

    Emer R McGrath, Jayandra J Himali, Daniel Levy, Sarah C Conner, Charles DeCarli, Matthew P Pase, Toshiharu Ninomiya, Tomoyuki Ohara, Paul Courchesne, Claudia L Satizabal, Ramachandran S Vasan, Alexa S Beiser, Sudha Seshadri

    Journal of the American Heart Association   9 ( 19 )   e014659   2020.10

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    DOI: 10.1161/JAHA.119.014659

  • Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama Study. International journal

    Akane Mihara, Tomoyuki Ohara, Jun Hata, Takanori Honda, Sanmei Chen, Satoko Sakata, Emi Oishi, Yoichiro Hirakawa, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya

    Atherosclerosis   311   52 - 59   2020.10

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    DOI: 10.1016/j.atherosclerosis.2020.08.016

  • Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan. International journal

    Daigo Yoshida, Tomoyuki Ohara, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Takanori Honda, Yoshihiko Furuta, Emi Oishi, Satoko Sakata, Shigenobu Kanba, Takanari Kitazono, Toshiharu Ninomiya

    Neurology   95 ( 5 )   e508-e518   2020.8

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    DOI: 10.1212/WNL.0000000000009917

  • Serum homocysteine and risk of dementia in Japan Reviewed

    Sanmei Chen, Takanori Honda, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Mao Shibata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Takanari Kitazono, Toshiharu Ninomiya

    Journal of Neurology, Neurosurgery and Psychiatry   91 ( 5 )   540 - 546   2020.5

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    DOI: 10.1136/jnnp-2019-322366

  • Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study.

    Keisuke Yamasaki, Jun Hata, Yoshihiko Furuta, Naoki Hirabayashi, Tomoyuki Ohara, Daigo Yoshida, Yoichiro Hirakawa, Toshiaki Nakano, Takanari Kitazono, Toshiharu Ninomiya

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 6 )   935 - 942   2020.5

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    DOI: 10.1253/circj.CJ-19-1069

  • Association of anthropometry and weight change with risk of dementia and its major subtypes A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia Reviewed

    Obesity Reviews   21 ( 4 )   2020.4

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    DOI: 10.1111/obr.12989

  • Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. Reviewed International journal

    Obesity reviews : an official journal of the International Association for the Study of Obesity   21 ( 4 )   e12989   2020.4

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    DOI: 10.1111/obr.12989

  • Serum homocysteine and risk of dementia in Japan. Reviewed International journal

    Sanmei Chen, Takanori Honda, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Mao Shibata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Takanari Kitazono, Toshiharu Ninomiya

    Journal of neurology, neurosurgery, and psychiatry   2020.3

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    DOI: 10.1136/jnnp-2019-322366

  • Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease A Systematic Review and Meta-Analysis Reviewed

    , Phillip J. Tully, Yuichiro Yano, Lenore J. Launer, Kazuomi Kario, Michiaki Nagai, Simon P. Mooijaart, Jurgen A.H.R. Claassen, Simona Lattanzi, Andrew D. Vincent, Christophe Tzourio, Kaarin J. Anstey, Nigel Beckett, Alexa S. Beiser, Jonathan Birns, Adam M. Brickman, Nicholas R. Burns, Mahir Cengiz, Suzanne Cosh, Rianne A.A. de Heus, Peter W. de Leeuw, Diana Dorstyn, Merrill F. Elias, J. Wouter Jukema, Masahiro Kikuya, Abraham A. Kroon, Rajiv Mahajan, Emer R. McGrath, Eric P. Moll van Charante, Toshiharu Ninomiya, Tomoyuki Ohara, Takayoshi Ohkubo, Emi Oishi, Ruth Peters, Edo Richard, Michihiro Satoh, Joseph Selvayanagam, Sudha Seshadri, David J. Stott, Stella Trompet, Willem A. van Gool, Tessa van Middelaar, Deborah A. Turnbull

    Journal of the American Heart Association   9 ( 1 )   2020.1

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    DOI: 10.1161/JAHA.119.013841

  • Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study. Reviewed

    11 ( 4 )   971 - 979   2020.1

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    AIMS/INTRODUCTION: To investigate the association of alternative glycemic measures - namely, serum glycated albumin (GA), hemoglobin A1c (HbA1c ) and the GA : HbA1c ratio - with global brain and hippocampal atrophy in a general elderly Japanese population. MATERIALS AND METHODS: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. RESULTS: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA1c ratio levels (all P for trend < 0.05), but not with higher HbA1c levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA1c ratio levels, but not HbA1c , were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. CONCLUSIONS: The present study suggests that higher serum GA and higher GA : HbA1c ratio are significantly associated with global brain and hippocampal atrophy.

    DOI: 10.1111/jdi.13220

  • Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community The Hisayama study Reviewed

    Yozo Hatabe, Mao Shibata, Tomoyuki Ohara, Emi Oishi, Daigo Yoshida, Takanori Honda, Jun Hata, Shigenobu Kanba, Takanari Kitazono, Toshiharu Ninomiya

    Journal of epidemiology   30 ( 1 )   15 - 23   2020.1

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    DOI: 10.2188/jea.JE20180137

  • Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease The Hisayama study Reviewed

    Hideomi Hamasaki, Hiroyuki Honda, Satoshi O. Suzuki, Masahiro Shijo, Tomoyuki Ohara, Yozo Hatabe, Tsuyoshi Okamoto, Toshiharu Ninomiya, Toru Iwaki

    Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring   11   415 - 423   2019.12

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    DOI: 10.1016/j.dadm.2019.04.008

  • Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study. Reviewed International journal

    Hamasaki H, Honda H, Suzuki SO, Shijo M, Ohara T, Hatabe Y, Okamoto T, Ninomiya T, Iwaki T

    Alzheimer's & dementia (Amsterdam, Netherlands)   11   415 - 423   2019.12

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    Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study.
    Introduction: We have conducted the pathological cohort study of autopsied cases of Hisayama residents to reveal a recent trend of dementia-related pathology. We noticed a trend of putaminal involvement of Alzheimer's disease (AD) with parkinsonism. Then, we investigated the accurate prevalence of neurological diseases with putaminal AD pathology in the general population. Methods: We examined a series of 291 autopsies in the Hisayama study and performed image analysis of immunohistochemistry for microtubule-associated protein tau (MAPT) and amyloid β. Results: Approximately 65.6&#37; and 36.1&#37; of cases showed putaminal MAPT and amyloid deposits, respectively. Diffuse deposits of them were mainly found in the AD cases. Putaminal MAPT was highly associated with AD-related pathological criteria. Four of 22 cases with severe putaminal MAPT deposition were documented as having developed parkinsonism. Discussion: Severe MAPT accumulation in the basal ganglia was closely related to the development of AD pathology and could occur most frequently in AD cases without comorbidities.

    DOI: 10.1016/j.dadm.2019.04.008

  • Serum elaidic acid concentration and risk of dementia The Hisayama Study Reviewed

    Takanori Honda, Tomoyuki Ohara, Masakazu Shinohara, Jun Hata, Ryuji Toh, Daigo Yoshida, Mao Shibata, Tatsuro Ishida, Yoichiro Hirakawa, Yasuhiro Irino, Satoko Sakata, Kazuhiro Uchida, Takanari Kitazono, Shigenobu Kanba, Ken Ichi Hirata, Toshiharu Ninomiya

    Neurology   93 ( 22 )   E2053 - E2064   2019.11

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    DOI: 10.1212/WNL.0000000000008464

  • Serum elaidic acid concentration and risk of dementia: The Hisayama study. Reviewed International journal

    Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T

    Neurology   93 ( 22 )   e2053-e2064   2019.10

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    Serum elaidic acid concentration and risk of dementia: The Hisayama study.
    OBJECTIVE: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. METHODS: In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. RESULTS: During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend <0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. CONCLUSIONS: The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.

    DOI: 10.1212/WNL.0000000000008464

  • Association between Serum β-Alanine and Risk of Dementia Reviewed

    188 ( 9 )   1637 - 1645   2019.9

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    We examined the association between serum concentrations of β-alanine, a metabolite of carnosine and anserine, and the risk of dementia in a general population of elderly Japanese persons. In 2007, 1,475 residents of Hisayama, Japan, aged 60-79 years and without dementia were divided into 4 groups according to quartiles of serum β-alanine concentrations (quartile 1, lowest; quartile 4, highest) and followed for a median of 5.3 years. During follow-up, 117 subjects developed all-cause dementia (Alzheimer in 77 cases and vascular dementia in 31). The risk of all-cause dementia decreased with increasing serum β-alanine levels after adjustment for potential confounding factors (quartile 2, hazard ratio (HR) = 0.73 (95% confidence interval (CI): 0.45, 1.18); quartile 3, HR = 0.50 (95% CI: 0.28, 0.89); quartile 4, HR = 0.50 (95% CI: 0.27, 0.92); P = 0.01 for trend). A similar inverse association was observed for Alzheimer disease (quartile 2, HR = 0.78 (95% CI: 0.44, 1.38); quartile 3, HR = 0.53 (95% CI: 0.26, 1.06); quartile 4, HR = 0.53 (95% CI: 0.25, 1.10); P = 0.04 for trend) but not for vascular dementia. We found that higher serum β-alanine levels were significantly associated with lower risks of all-cause dementia and Alzheimer disease. Because serum β-alanine levels reflect intakes of carnosine/anserine, higher intakes of carnosine/anserine might be beneficial for the prevention of dementia.

    DOI: 10.1093/aje/kwz116

  • NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. Reviewed International journal

    Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T

    Journal of the American Heart Association   8 ( 17 )   e011652   2019.9

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    NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study.
    Background Epidemiological evidence implies a link between heart disease and dementia. However, few prospective studies have assessed the association between serum NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels and dementia. Methods and Results A total of 1635 community-dwelling Japanese elderly aged ≥60 years without dementia (57&#37; women, mean age±SD 70.8±7.7 years) were followed up for 10 years. Serum NT-proBNP levels were divided into 4 categories (≤54, 55-124, 125-299, and ≥300 pg/mL). The hazard ratios were estimated using a Cox proportional hazards model. During the follow-up period, 377 subjects developed all-cause dementia, 247 Alzheimer disease, and 102 vascular dementia. The age- and sex-adjusted incidence of all-cause dementia was 31.5 per 1000 person-years and increased significantly with higher serum NT-proBNP levels, being 16.4, 32.0, 35.7, and 45.5, respectively (P for trend <0.01). Subjects with serum NT-proBNP levels of ≥300 pg/mL had a significantly higher risk of all-cause dementia (hazard ratio=2.46, 95&#37; CI 1.63-3.71) than those with serum NT-proBNP levels of ≤54 pg/mL after adjusting for confounders. Similar risks were observed for Alzheimer disease and vascular dementia. Incorporation of the serum NT-proBNP level into a model with known risk factors for dementia significantly improved the predictive ability for incident dementia (c-statistics 0.780-0.787, P=0.02; net reclassification improvement 0.189, P=0.001; integrated discrimination improvement 0.011, P=0.003). Conclusions Higher serum NT-proBNP levels were significantly associated with an increased risk of dementia. Serum NT-proBNP could be a novel biomarker for predicting future risk of dementia in the general elderly population.

    DOI: 10.1161/JAHA.118.011652

  • NT-proBNP and Risk of Dementia in a General Japanese Elderly Population The Hisayama Study Reviewed

    Takuya Nagata, Tomoyuki Ohara, Jun Hata, Satoko Sakata, Yoshihiko Furuta, Daigo Yoshida, Takanori Honda, Yoichiro Hirakawa, Tomomi Ide, Shigenobu Kanba, Takanari Kitazono, Hiroyuki Tsutsui, Toshiharu Ninomiya

    Journal of the American Heart Association   8 ( 17 )   e011652   2019.9

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    DOI: 10.1161/JAHA.118.011652

  • Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988–2012 the Hisayama Study Reviewed

    10 ( 3 )   198 - 205   2019.7

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    Objective: We estimated secular trends in the prevalence of type 2 diabetes (T2DM) and prediabetes, and examined potential explanatory factors for these trends in a Japanese community. Methods: 4 cross-sectional examinations were conducted among subjects aged 40–79 years in 1988 (n = 2,490), 2002 (n = 2,856), 2007 (n = 2,761), and 2012 (n = 2,644). Glucose tolerance status was defined by a 75g oral glucose tolerance test. Results: The age-standardized prevalence of T2DM increased significantly in both sexes from 1988 to 2002, and thereafter it remained stable in men, and decreased nonsignificantly in women from 2002 to 2012. The age-standardized prevalence of prediabetes in men increased significantly between 1988 and 2002, but then decreased significantly. A similar trend was observed in women. The age-specific prevalence of T2DM increased greatly in men aged 60–79 years and women aged 70–79 years from 1988 to 2002, and then plateaued at a high level, while a significant decreasing trend was observed in women aged 40–49 years. The mean values of body mass index (BMI) increased steeply in these elderly subjects from 1988 to 2002, and remained at a high level, whereas those in middle-aged women decreased appreciably over the study period. Conclusions: Our findings suggest that in Japanese, there was no further increase in the prevalence of T2DM or prediabetes in either men or women in the 2000s. Secular change in the BMI level was likely to contribute to trends in the prevalence of T2DM, and thus the management of obesity may be important to reduce the prevalence of T2DM.

    DOI: 10.1007/s13340-018-0380-0

  • Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988-2012: the Hisayama Study. Reviewed

    Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Nakamura U, Kitazono T, Ninomiya T

    Diabetology international   10 ( 3 )   198 - 205   2019.7

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    Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988-2012: the Hisayama Study.

    DOI: 10.1007/s13340-018-0380-0

  • Dairy consumption and risk of functional disability in an elderly Japanese population The Hisayama Study Reviewed

    Daigo Yoshida, Tomoyuki Ohara, Jun Hata, Mao Shibata, Yoichiro Hirakawa, Takanori Honda, Kazuhiro Uchida, Satoshi Takasugi, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    American Journal of Clinical Nutrition   109 ( 6 )   1664 - 1671   2019.6

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    DOI: 10.1093/ajcn/nqz040

  • Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study. Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T

    The American journal of clinical nutrition   109 ( 6 )   1664 - 1671   2019.6

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    Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study.
    BACKGROUND: Little is known about the association between dairy intake and risk of functional disability in the elderly. OBJECTIVES: We examined the influence of dairy intake on the development of declining functional capacity and activities of daily living (ADL) in a prospective cohort study of an elderly population. METHODS: A total of 859 community-dwelling Japanese residents, aged ≥65 y without functional disability, were followed up for 7 y. Functional capacity impairment was defined as a Tokyo Metropolitan Institute of Gerontology Index of Competence score of ≤12, and ADL disability was defined as a Barthel Index score of ≤95. Dairy intake was evaluated using a 150-item semiquantitative food frequency questionnaire, grouped into quartiles. The RR of dairy intake on incident functional disability was computed using a Poisson regression model. RESULTS: The multivariable-adjusted RR of impaired functional capacity decreased significantly with increasing dairy intake levels (RR [95&#37; CI]: quartile 1, 1.00 [reference]; quartile 2, 0.85 [0.71, 1.02]; quartile 3, 0.81 [0.68, 0.98]; and quartile 4, 0.74 [0.61, 0.90]; P-trend = 0.001). Regarding the three subscales of functional capacity, the inverse association between dairy intake and risk for impairment of intellectual activity and social role remained significant (P-trend = 0.0009 and 0.02, respectively), but such an association was not observed for instrumental ADL. The multivariable-adjusted risk of ADL disability also decreased weakly but significantly with elevating dairy intake (P-trend = 0.04). A similar association was seen for severity of functional disability (P-trend = 0.002). However, the magnitude of these associations was attenuated after further adjustment for protein intake. CONCLUSION: Our findings suggest that higher dairy intake is associated with a lower risk of functional disability and its progression in the elderly, probably via an increase in protein intake.

    DOI: 10.1093/ajcn/nqz040

  • Objectively measured sedentary time and diabetes mellitus in a general Japanese population The Hisayama Study Reviewed

    Takanori Honda, Hiro Kishimoto, Naoko Mukai, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Mao Shibata, Tomoyuki Ohara, Shuzo Kumagai, Toshiharu Ninomiya

    Journal of Diabetes Investigation   10 ( 3 )   809 - 816   2019.5

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    DOI: 10.1111/jdi.12968

  • Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study. Reviewed

    Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Hirakawa Y, Shibata M, Ohara T, Kumagai S, Ninomiya T

    Journal of diabetes investigation   10 ( 3 )   809 - 816   2019.5

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    Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study.

    DOI: 10.1111/jdi.12968

  • Association Between Serum β-alanine and Risk of Dementia: the Hisayama Study. Reviewed

    2019.5

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    DOI: 10.1093/aje/kwz116

  • 地域住民における中年期から高齢期にかけての長期の運動歴と認知機能低下に関する研究 : 前向きコホート研究

    本田 貴紀, 吉田 大悟, 岸本 裕歩, 小原 知之, 平林 直樹, 古田 芳彦, 二宮 利治

    34   40 - 45   2019.4

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  • Prevalence of adult epilepsy in a general Japanese population The Hisayama study Reviewed

    Akihiro Tanaka, Jun Hata, Naoki Akamatsu, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Tomoyuki Ohara, Toshiki Mizuno, Sadatoshi Tsuji, Takanari Kitazono, Toshiharu Ninomiya

    Epilepsia Open   4 ( 1 )   182 - 186   2019.3

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    DOI: 10.1002/epi4.12295

  • Prevalence of adult epilepsy in a general Japanese population: The Hisayama study. Reviewed International journal

    Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T

    Epilepsia open   4 ( 1 )   182 - 186   2019.3

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    Prevalence of adult epilepsy in a general Japanese population: The Hisayama study.
    The aim of the present study was to examine the prevalence and causes of adult epilepsy in a general Japanese population. We examined a total of 3333 Japanese residents in the town of Hisayama aged ≥40 years in 2012-2013. The examination was performed mainly at the municipal center for health promotion, but some subjects were examined in their homes, hospitals, or nursing homes. Twenty-three subjects had a diagnosis of epilepsy. The prevalence (95&#37; confidence interval [CI]) of epilepsy per 1000 was 6.9 (4.1-9.7) in total, 4.9 (1.3-8.5) in men, and 8.4 (4.3-12.5) in women (P = 0.23 between sexes). The prevalence of epilepsy was significantly higher in the elderly (aged ≥65 years; 10.3 per 1000 [95&#37; CI 5.4-15.1]) than in the middle-aged (aged 40-64 years; 3.6 per 1000 [95&#37; CI 0.7-6.4]; P = 0.02). The major cause of epilepsy was cerebrovascular diseases (n = 11; 48&#37; of the epilepsy patients). More than half of the epilepsy patients experienced the first episode of seizure in older age (≥65 years; n = 13; 57&#37;). The findings of this study suggest the clinical importance of the prevention of cerebrovascular diseases to reduce the burden of epilepsy in the future.

    DOI: 10.1002/epi4.12295

  • Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study. Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T

    Annals of neurology   85 ( 1 )   47 - 58   2019.1

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    Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study.
    OBJECTIVE: To investigate the association between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor expressed on the microglia, and the risk of dementia. METHODS: A total of 1,349 Japanese community residents aged 60 and older without dementia were followed prospectively for 10 years (2002-2012). Serum sTREM2 levels were quantified by using an enzyme-linked immunosorbent assay and divided into quartiles. Cox proportional hazards model was used to estimate the hazard ratios (HRs) of serum sTREM2 levels on the risk of dementia. RESULTS: During the follow-up, 300 subjects developed all-cause dementia; 193 had Alzheimer's disease (AD), and 85 had vascular dementia (VaD). The age- and sex-adjusted incidences of all-cause dementia, AD, and VaD elevated significantly with higher serum sTREM2 levels (all p for trend < 0.012). These associations were not altered after adjustment for confounding factors, including high-sensitive C-reactive protein. Subjects with the highest quartile of serum sTREM2 levels had significantly higher multivariable-adjusted risks of developing all-cause dementia, AD, and VaD than those with the lowest quartile (HR = 2.03, 95&#37; confidence interval [CI] = 1.39-2.97, p < 0.001 for all-cause dementia; HR = 1.62, 95&#37; CI = 1.02-2.55, p = 0.04 for AD; HR = 2.85, 95&#37; CI = 1.35-6.02, p = 0.006 for VaD). No significant heterogeneity in the association of serum sTREM2 levels with the development of dementia was observed among the other risk factor subgroups (all p for heterogeneity > 0.11). INTERPRETATION: The present findings suggest a significant association between increased serum sTREM2 levels and the risk of developing all-cause dementia, AD, and VaD in the general elderly Japanese population. ANN NEUROL 2019;85:47-58.

    DOI: 10.1002/ana.25385

  • Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community: the Hisayama Study. Reviewed

    Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T

    Journal of epidemiology   30 ( 1 )   15 - 23   2018.12

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    Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community: the Hisayama Study.
    BACKGROUND: The association between decline in handgrip strength from midlife to late life and dementia is unclear. METHODS: Japanese community-dwellers without dementia aged 60 to 79 years (ie, individuals in late life; mean age, 68 years) were followed for 24 years (1988-2012) (n = 1,055); 835 of them had participated in a health examination in 1973-1974 (mean age, 53 years), and these earlier data were used for the midlife analysis. Using a Cox proportional hazards model, we estimated the risk conferred by a decline in handgrip strength over a 15-year period (1973-74 to 1988) from midlife to late life on the development of total dementia, Alzheimer's disease (AD), and vascular dementia (VaD) over the late-life follow-up period from 1988 to 2012. RESULTS: During the follow-up, 368 subjects experienced total dementia. The age- and sex-adjusted incidence of total dementia increased significantly with greater decline in handgrip strength (increased or unchanged handgrip strength [≥+0&#37;] 25.1, mildly decreased [-14 to -1&#37;] 28.4, and severely decreased [≤-15&#37;] 38.9 per 1,000 person-years). A greater decline in handgrip strength was significantly associated with higher risk of total dementia after adjusting for potential confounding factors; subjects with severely decreased handgrip strength had 1.51-fold (95&#37; confidence interval, 1.14-1.99, P < 0.01) increased risk of total dementia compared to those with increased or unchanged handgrip strength. Similar significant findings were observed for AD, but not for VaD. CONCLUSIONS: Our findings suggest that a greater decline in handgrip strength from midlife to late life is an important indicator for late-life onset of dementia.

    DOI: 10.2188/jea.JE20180137

  • Reply to “Long sleep duration An epiphenomenon or a risk for dementia?” Reviewed

    66 ( 11 )   2225 - 2226   2018.11

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    DOI: 10.1111/jgs.15558

  • Reply to "Long sleep duration: An epiphenomenon or a risk for dementia?" Reviewed

    Ohara T, Ninomiya T

    Journal of the American Geriatrics Society   66 ( 11 )   2225 - 2226   2018.11

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    Reply to "Long sleep duration: An epiphenomenon or a risk for dementia?"

    DOI: 10.1111/jgs.15558

  • The association between blood pressure variability (BPV) with dementia and cognitive function A systematic review and meta-analysis protocol 11 Medical and Health Sciences 1117 Public Health and Health Services Reviewed

    Phillip J. Tully, Deborah A. Turnbull, Kaarin J. Anstey, Nigel Beckett, Alexa S. Beiser, Jonathan Birns, Adam M. Brickman, Nicholas R. Burns, Suzanne Cosh, Peter W. De Leeuw, Diana Dorstyn, Merrill F. Elias, J. Wouter Jukema, Kazuomi Kario, Masahiro Kikuya, Abraham A. Kroon, Lenore J. Launer, Rajiv Mahajan, Emer R. McGrath, Simon P. Mooijaart, Eric P. Moll Van Charante, Michiaki Nagai, Toshiharu Ninomiya, Tomoyuki Ohara, Takayoshi Ohkubo, Emi Oishi, Ruth Peters, Edo Richard, Michihiro Satoh, Sudha Seshadri, David J. Stott, Willem A. Van Gool, Tessa Van Middelaar, Stella Trompet, Kristy Giles, Phoebe Drioli-Phillips, Umama Aaimir, Frank Connolly, Christophe Tzourio

    Systematic Reviews   7 ( 1 )   2018.10

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    DOI: 10.1186/s13643-018-0811-9

  • Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community. Reviewed

    Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T

    Journal of the American Geriatrics Society   66 ( 10 )   1911 - 1918   2018.10

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    Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community.

    DOI: 10.1111/jgs.15446

  • Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population the Hisayama Study Reviewed

    Mao Shibata, Tomoyuki Ohara, Daigo Yoshida, Jun Hata, Naoko Mukai, Hiroyuki Kawano, Shigenobu Kanba, Takanari Kitazono, Toshiharu Ninomiya

    Journal of Affective Disorders   237   73 - 79   2018.9

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    DOI: 10.1016/j.jad.2018.05.004

  • Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study Reviewed

    Mao Shibata, Tomoyuki Ohara, Daigo Yoshida, Jun Hata, Naoko Mukai, Hiroyuki Kawano, Shigenobu Kanba, Takanari Kitazono, Toshiharu Ninomiya

    Journal of Affective Disorders   237   73 - 79   2018.9

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    DOI: 10.1016/j.jad.2018.05.004

  • Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer’s disease Reviewed

    137 ( 6-7 )   521 - 533   2018.7

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    Alzheimer’s disease (AD) is a common neurological disease that causes dementia in humans. Although the reports of associated pathological genes have been increasing, the molecular mechanism leading to the accumulation of amyloid-β (Aβ) in human brain is still not well understood. To identify novel genes that cause accumulation of Aβ in AD patients, we conducted an integrative analysis by combining a human genetic association study and transcriptome analysis in mouse brain. First, we examined genome-wide gene expression levels in the hippocampus, comparing them to amyloid Aβ level in mice with mixed genetic backgrounds. Next, based on a GWAS statistics obtained by a previous study with human AD subjects, we obtained gene-based statistics from the SNP-based statistics. We combined p values from the two types of analysis across orthologous gene pairs in human and mouse into one p value for each gene to evaluate AD susceptibility. As a result, we found five genes with significant p values in this integrated analysis among the 373 genes analyzed. We also examined the gene expression level of these five genes in the hippocampus of independent human AD cases and control subjects. Two genes, LBH and SHF, showed lower expression levels in AD cases than control subjects. This is consistent with the gene expression levels of both the genes in mouse which were negatively correlated with Aβ accumulation. These results, obtained from the integrative approach, suggest that LBH and SHF are associated with the AD pathogenesis.

    DOI: 10.1007/s00439-018-1906-z

  • Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease. Reviewed

    2018.7

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    DOI: 10.1007/s00439-018-1906-z

  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community Reviewed

    Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Neurology: Clinical Practice   8 ( 3 )   223 - 231   2018.6

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    DOI: 10.1212/CPJ.0000000000000464

  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community. Reviewed

    Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T

    Neurology. Clinical practice   8 ( 3 )   223 - 231   2018.6

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    Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community.

    DOI: 10.1212/CPJ.0000000000000464

  • Development and validation of a risk assessment tool for gastric cancer in a general Japanese population Reviewed

    Masahiro Iida, Fumie Ikeda, Jun Hata, Yoichiro Hirakawa, Tomoyuki Ohara, Naoko Mukai, Daigo Yoshida, Koji Yonemoto, Motohiro Esaki, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Gastric Cancer   21 ( 3 )   383 - 390   2018.5

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    DOI: 10.1007/s10120-017-0768-8

  • Development and validation of a risk assessment tool for gastric cancer in a general Japanese population Reviewed

    Masahiro Iida, Fumie Ikeda, Jun Hata, Yoichiro Hirakawa, Tomoyuki Ohara, Naoko Mukai, Daigo Yoshida, Koji Yonemoto, Motohiro Esaki, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Gastric Cancer   21 ( 3 )   383 - 390   2018.5

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    DOI: 10.1007/s10120-017-0768-8

  • 地域住民における糖尿病有病率の時代的変化、1988-2012年 久山町研究

    向井 直子, 秦 淳, 平川 洋一郎, 小原 知之, 吉田 大悟, 中村 宇大, 北園 孝成, 二宮 利治

    糖尿病   61 ( Suppl.1 )   S - 376   2018.4

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  • Association of sarcopenic obesity predicted by anthropometric measurements and 24-y all-cause mortality in elderly men The Kuakini Honolulu Heart Program Reviewed

    Kiyoshi Sanada, Randi Chen, Bradley Willcox, Tomoyuki Ohara, Aida Wen, Cody Takenaka, Kamal Masaki

    Nutrition   46   97 - 102   2018.2

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    DOI: 10.1016/j.nut.2017.09.003

  • Association of sarcopenic obesity predicted by anthropometric measurements and 24-y all-cause mortality in elderly men: The Kuakini Honolulu Heart Program Reviewed

    Kiyoshi Sanada, Randi Chen, Bradley Willcox, Tomoyuki Ohara, Aida Wen, Cody Takenaka, Kamal Masaki

    Nutrition   46   97 - 102   2018.2

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    DOI: 10.1016/j.nut.2017.09.003

  • Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly The hisayama study Reviewed

    Keita Takae, Jun Hata, Tomoyuki Ohara, Daigo Yoshida, Mao Shibata, Naoko Mukai, Yoichiro Hirakawa, Hiro Kishimoto, Kazuhiko Tsuruya, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Journal of the American Heart Association   7 ( 2 )   2018.1

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    DOI: 10.1161/JAHA.117.006693

  • Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: The hisayama study Reviewed

    Keita Takae, Jun Hata, Tomoyuki Ohara, Daigo Yoshida, Mao Shibata, Naoko Mukai, Yoichiro Hirakawa, Hiro Kishimoto, Kazuhiko Tsuruya, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Journal of the American Heart Association   7 ( 2 )   2018.1

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    DOI: 10.1161/JAHA.117.006693

  • Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation Reviewed

    Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Sakumi Kunihiko, Frank M. Laferla, Yusaku Nakabeppu

    Scientific Reports   7 ( 1 )   2017.12

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    DOI: 10.1038/s41598-017-17999-3

  • The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: The Hisayama Study. Reviewed

    27 ( 12 )   578 - 583   2017.12

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    DOI: 10.1016/j.je.2017.01.004

  • Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation Reviewed

    Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Kunihiko Sakumi, Frank M. LaFerla, Yusaku Nakabeppu

    SCIENTIFIC REPORTS   7 ( 1 )   17762   2017.12

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    DOI: 10.1038/s41598-017-17999-3

  • Author response Trends in dementia prevalence, incidence, and survival rate in a Japanese community Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya

    Neurology   89 ( 18 )   1930 - 1931   2017.10

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    DOI: 10.1212/WNL.0000000000004590

  • AUTHOR RESPONSE: TRENDS IN DEMENTIA PREVALENCE, INCIDENCE, AND SURVIVAL RATE IN A JAPANESE COMMUNITY Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya

    NEUROLOGY   89 ( 18 )   1930 - 1931   2017.10

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    DOI: 10.1212/WNL.0000000000004590

  • Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population - The Hisayama Study - Reviewed

    Kaoru Umehara, Naoko Mukai, Jun Hata, Yoichiro Hirakawa, Tomoyuki Ohara, Daigo Yoshida, Hiro Kishimoto, Takanari Kitazono, Sumio Hoka, Yutaka Kiyohara, Toshiharu Ninomiya

    CIRCULATION JOURNAL   81 ( 9 )   1315 - +   2017.9

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    DOI: 10.1253/circj.CJ-16-0954

  • Alternative measures of hyperglycemia and risk of Alzheimer's disease in the community The hisayama study Reviewed

    Naoko Mukai, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Masafumi Koga, Udai Nakamura, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Journal of Clinical Endocrinology and Metabolism   102 ( 8 )   3002 - 3010   2017.8

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    DOI: 10.1210/jc.2017-00439

  • Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population The Hisayama Study Reviewed

    Emi Oishi, Tomoyuki Ohara, Satoko Sakata, Masayo Fukuhara, Jun Hata, Daigo Yoshida, Mao Shibata, Toshio Ohtsubo, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    CIRCULATION   136 ( 6 )   516 - +   2017.8

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    DOI: 10.1161/CIRCULATIONAHA.116.025667

  • Alternative Measures of Hyperglycemia and Risk of Alzheimer's Disease in the Community: The Hisayama Study Reviewed

    Naoko Mukai, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Masafumi Koga, Udai Nakamura, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   102 ( 8 )   3002 - 3010   2017.8

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    DOI: 10.1210/jc.2017-00439

  • Dietary Protein Intake and Stroke Risk in a General Japanese Population The Hisayama Study Reviewed

    Mio Ozawa, Daigo Yoshida, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Mao Shibata, Kazuhiro Uchida, Masashi Nagata, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Stroke   48 ( 6 )   1478 - 1486   2017.6

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    DOI: 10.1161/STROKEAHA.116.016059

  • The changing prevalence and incidence of dementia over time - current evidence (vol 13, pg 327, 2017) Reviewed

    Yu-Tzu Wu, Alexa S. Beiser, Monique M. B. Breteler, Laura Fratiglioni, Catherine Helmer, Hugh C. Hendrie, Hiroyuki Honda, M. Arfan Ikram, Kenneth M. Langa, Antonio Lobo, Fiona E. Matthews, Tomoyuki Ohara, Karine Peres, Chengxuan Qiu, Sudha Seshadri, Britt-Marie Sjolund, Ingmar Skoog, Carol Brayne

    NATURE REVIEWS NEUROLOGY   13 ( 6 )   339 - 339   2017.6

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    DOI: 10.1038/nrneurol.2017.63

  • Dietary Protein Intake and Stroke Risk in a General Japanese Population The Hisayama Study Reviewed

    Mio Ozawa, Daigo Yoshida, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Mao Shibata, Kazuhiro Uchida, Masashi Nagata, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    STROKE   48 ( 6 )   1478 - +   2017.6

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    DOI: 10.1161/STROKEAHA.116.016059

  • Tooth Loss and Risk of Dementia in the Community the Hisayama Study Reviewed

    Kenji Takeuchi, Tomoyuki Ohara, Michiko Furuta, Toru Takeshita, Yukie Shibata, Jun Hata, Daigo Yoshida, Yoshihisa Yamashita, Toshiharu Ninomiya

    Journal of the American Geriatrics Society   65 ( 5 )   e95 - e100   2017.5

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    DOI: 10.1111/jgs.14791

  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community Reviewed

    Tomoyuki Ohara, Jun Hata, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Toru Iwaki, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara, Toshiharu Ninomiya

    NEUROLOGY   88 ( 20 )   1925 - 1932   2017.5

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    DOI: 10.1212/WNL.0000000000003932

  • Tooth Loss and Risk of Dementia in the Community: the Hisayama Study Reviewed

    Kenji Takeuchi, Tomoyuki Ohara, Michiko Furuta, Toru Takeshita, Yukie Shibata, Jun Hata, Daigo Yoshida, Yoshihisa Yamashita, Toshiharu Ninomiya

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   65 ( 5 )   E95 - E100   2017.5

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    DOI: 10.1111/jgs.14791

  • Association between serum vitamin D and All-Cause and Cause-Specific death in a general Japanese population ― the hisayama study ― Reviewed

    81 ( 9 )   1315 - 1321   2017.1

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    Background: Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations. Methods and Results: We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002-2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)2D levels (HR 1.54 [95% confidence interval, 1.18-2.01] for the lowest quartile, 1.31 [0.99-1.73] for the 2nd quartile, 0.94 [0.70-1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than in those with eGFR ≥60 mL/min/1.73 m2; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). Conclusions: The findings suggested that a lower serum 1,25(OH)2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.

    DOI: 10.1253/circj.CJ-16-0954

  • The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community The Hisayama Study Reviewed

    Masaharu Nagata, Jun Hata, Yoichiro Hirakawa, Naoko Mukai, Daigo Yoshida, Tomoyuki Ohara, Hiro Kishimoto, Hiroyuki Kawano, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Journal of Epidemiology   27 ( 12 )   578 - 583   2017.1

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    DOI: 10.1016/j.je.2017.01.004

  • Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population The Hisayama Study Reviewed

    Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Sachiko Koyama, Satoshi Suzuki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Toru Iwaki

    Journal of Alzheimer's Disease   55 ( 2 )   613 - 624   2017.1

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    DOI: 10.3233/JAD-160521

  • Day-to-day blood pressure variability and dementia Reviewed

    Tomoyuki Ohara, Emi Oishi, Toshiharu Ninomiya

    Oncotarget   8 ( 70 )   114416 - 114417   2017.1

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    DOI: 10.18632/oncotarget.22993

  • Combination of Helicobacter pylori Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study Reviewed

    Fumie Ikeda, Kentaro Shikata, Jun Hata, Masayo Fukuhara, Yoichiro Hirakawa, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Daigo Yoshida, Koji Yonemoto, Motohiro Esaki, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    JOURNAL OF EPIDEMIOLOGY   26 ( 12 )   629 - 636   2016.12

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    DOI: 10.2188/jea.JE20150258

  • Association between diabetes and hippocampal atrophy in Elderly Japanese The Hisayama study Reviewed

    Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Gotoh, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya

    Diabetes Care   39 ( 9 )   1543 - 1549   2016.9

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    DOI: 10.2337/dc15-2800

  • Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study Reviewed

    Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Gotoh, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya

    DIABETES CARE   39 ( 9 )   1543 - 1549   2016.9

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    DOI: 10.2337/dc15-2800

  • Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community Reviewed

    Jun Hata, Naoko Mukai, Masaharu Nagata, Tomoyuki Ohara, Daigo Yoshida, Hiro Kishimoto, Mao Shibata, Yoichiro Hirakawa, Motoyoshi Endo, Tetsuro Ago, Takanari Kitazono, Yuichi Oike, Yutaka Kiyohara, Toshiharu Ninomiya

    Arteriosclerosis, Thrombosis, and Vascular Biology   36 ( 8 )   1686 - 1691   2016.8

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    DOI: 10.1161/ATVBAHA.116.307291

  • Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study Reviewed

    36 ( 4 )   383 - 387   2016.8

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    DOI: 10.1111/neup.12298

  • Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study. Reviewed

    36 ( 4 )   383 - 387   2016.8

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    DOI: 10.1111/neup.12298

  • Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community: The Hisayama Study Reviewed

    Jun Hata, Naoko Mukai, Masaharu Nagata, Tomoyuki Ohara, Daigo Yoshida, Hiro Kishimoto, Mao Shibata, Yoichiro Hirakawa, Motoyoshi Endo, Tetsuro Ago, Takanari Kitazono, Yuichi Oike, Yutaka Kiyohara, Toshiharu Ninomiya

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   36 ( 8 )   1686 - 1691   2016.8

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    DOI: 10.1161/ATVBAHA.116.307291

  • Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study Reviewed

    36 ( 4 )   383 - 387   2016.8

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    We investigated the trends in dementia over the past 29 years in the town of Hisayama, Japan using 1266 autopsy specimens. The Hisayama study is a prospective cohort study of lifestyle-related diseases that was started in 1961. Clinical examination of dementia was started in 1985 with five detailed cross-sectional assessments conducted in 1985, 1992, 1998, 2005 and 2012. To examine the trends in dementia, we divided the 1266 autopsy samples into five groups according to the year of death: I (1986–1991, 257 cases), II (1992–1997, 268 cases), III (1998–2004, 318 cases), IV (2005–2011, 296 cases) and V (2012–2014, 127 cases). The prevalence of all-cause dementia significantly increased over time (28.4% in group I, 22.4% in group II, 32.1% in group III, 30.1% in group IV, 51.2% in group V; P for trend <0.001). A similar trend was observed for Alzheimer's disease (AD) (15.2%, 11.9%, 17.3%, 20.6% and 33.1%, respectively; P for trend <0.001). A significant increasing trend was observed in both men and women. A rapid increase in senile dementia of the NFT type (SD-NFT) in recent years was notable. Vascular dementia was the most common type of dementia in men prior to 2004; however, its prevalence decreased over time. Our study revealed that tauopathies, including AD and SD-NFT, significantly increased in the aged Japanese population over the course of this study. The neuritic plaque pathology of AD was associated with metabolic disorders such as insulin resistance and abnormal lipid metabolism, whereas the risk factors for tau pathology remain unclear. Although aging is considered one of the important risk factors accelerating tau pathology, there could be other risk factors associated with lifestyle diseases.

    DOI: 10.1111/neup.12298

  • Epidemiology of diabetes and risk of Dementia Reviewed

    Tomoyuki Ohara

    Brain and Nerve   68 ( 7 )   719 - 727   2016.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11477/mf.1416200500

  • Elevated 2-Hour Post-load Glucose Levels and Longer Duration of Diabetes Are Risk Factors for Hippocampal Atrophy in Elderly Japanese: The Hisayama Study Reviewed

    Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Goto, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya

    DIABETES   65   A361 - A361   2016.6

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    Language:English  

    DOI: 10.2337/dc15-2800

  • 認知症の危険因子と防御因子 (特集 認知症の診断と治療 : 最近の進歩)

    小原 知之, 神庭 重信

    臨床精神医学   45 ( 4 )   411 - 418   2016.4

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    Language:Japanese  

  • The long-term association between physical activity and risk of dementia in the community the Hisayama Study Reviewed

    Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara

    European Journal of Epidemiology   31 ( 3 )   267 - 274   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10654-016-0125-y

  • The long-term association between physical activity and risk of dementia in the community: the Hisayama Study Reviewed

    Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara

    EUROPEAN JOURNAL OF EPIDEMIOLOGY   31 ( 3 )   267 - 274   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10654-016-0125-y

  • Type 2diabetes as a risk factor for dementia in women compared with men A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia Reviewed

    Diabetes Care   39 ( 2 )   300 - 307   2016.2

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    DOI: 10.2337/dc15-1588

  • Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia Reviewed

    Saion Chatterjee, Sanne A. E. Peters, Mark Woodward, Silvia Mejia Arango, G. David Batty, Nigel Beckett, Alexa Beiser, Amy R. Borenstein, Paul K. Crane, Mary Haan, Linda B. Hassing, Kathleen M. Hayden, Yutaka Kiyohara, Eric B. Larson, Chung-Yi Li, Toshiharu Ninomiya, Tomoyuki Ohara, Ruth Peters, Tom C. Russ, Sudha Seshadri, Bjorn H. Strand, Rod Walker, Weili Xu, Rachel R. Huxley

    DIABETES CARE   39 ( 2 )   300 - 307   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc15-1588

  • Combination of helicobacter pylori antibody and serum pepsinogen as a good predictive tool of gastric cancer incidence 20-year prospective data from the hisayama study Reviewed

    Fumie Ikeda, Kentaro Shikata, Jun Hata, Masayo Fukuhara, Yoichiro Hirakawa, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Daigo Yoshida, Koji Yonemoto, Motohiro Esaki, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Journal of Epidemiology   26 ( 12 )   629 - 636   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea. JE20150258

  • Combination of helicobacter pylori antibody and serum pepsinogen as a good predictive tool of gastric cancer incidence 20-year prospective data from the hisayama study Reviewed

    Fumie Ikeda, Kentaro Shikata, Jun Hata, Masayo Fukuhara, Yoichiro Hirakawa, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Daigo Yoshida, Koji Yonemoto, Motohiro Esaki, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

    Journal of epidemiology   26 ( 12 )   629 - 636   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20150258

  • Midlife and Late-Life Smoking and Risk of Dementia in the Community: The Hisayama Study Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya, Jun Hata, Mio Ozawa, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Toru Iwaki, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   63 ( 11 )   2332 - 2339   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.13794

  • A genome-wide association study of late-onset Alzheimer's disease in a Japanese population Reviewed

    Atsushi Hirano, Tomoyuki Ohara, Atsushi Takahashi, Masayuki Aoki, Yuta Fuyuno, Kyota Ashikawa, Takashi Morihara, Masatoshi Takeda, Kouzin Kamino, Etsuko Oshima, Yuko Okahisa, Nobuto Shibata, Heii Arai, Hiroyasu Akatsu, Masashi Ikeda, Nakao Iwata, Toshiharu Ninomiya, Akira Monji, Takanari Kitazono, Yutaka Kiyohara, Michiaki Kubo, Shigenobu Kanba

    Psychiatric Genetics   25 ( 4 )   139 - 146   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/YPG.0000000000000090

  • A genome-wide association study of late-onset Alzheimer's disease in a Japanese population Reviewed

    Atsushi Hirano, Tomoyuki Ohara, Atsushi Takahashi, Masayuki Aoki, Yuta Fuyuno, Kyota Ashikawa, Takashi Morihara, Masatoshi Takeda, Kouzin Kamino, Etsuko Oshima, Yuko Okahisa, Nobuto Shibata, Heii Arai, Hiroyasu Akatsu, Masashi Ikeda, Nakao Iwata, Toshiharu Ninomiya, Akira Monji, Takanari Kitazono, Yutaka Kiyohara, Michiaki Kubo, Shigenobu Kanba

    PSYCHIATRIC GENETICS   25 ( 4 )   139 - 146   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/YPG.0000000000000090

  • DIETARY FACTORS AND INCIDENCE OF DEMENTIA: COX REGRESSION ANALYSIS WITH SPECIAL EMPHASIS ON THE NUMBER OF EVENTS RESPONSE Reviewed

    Mio Ozawa, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   62 ( 12 )   2467 - 2468   2014.12

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    Language:English  

    DOI: 10.1111/jgs.13163

  • Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study Reviewed

    Masaaki Hokama, Sugako Oka, Julio Leon, Toshiharu Ninomiya, Hiroyuki Honda, Kensuke Sasaki, Toru Iwaki, Tomoyuki Ohara, Tomio Sasaki, Frank M. LaFerla, Yutaka Kiyohara, Yusaku Nakabeppu

    CEREBRAL CORTEX   24 ( 9 )   2476 - 2488   2014.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bht101

  • Milk and Dairy Consumption and Risk of Dementia in an Elderly Japanese Population: The Hisayama Study Reviewed

    Mio Ozawa, Tomoyuki Ohara, Toshiharu Ninomiya, Jun Hata, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Kazuhiro Uchida, Tomoko Shirota, Takanari Kitazono, Yutaka Kiyohara

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   62 ( 7 )   1224 - 1230   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.12887

  • Altered expression of diabetes-related genes in Alzheimer's disease brains The Hisayama study Reviewed

    Masaaki Hokama, Sugako Oka, Julio Leon, Toshiharu Ninomiya, Hiroyuki Honda, Kensuke Sasaki, Toru Iwaki, Tomoyuki Ohara, Tomio Sasaki, Frank M. LaFerla, Yutaka Kiyohara, Yusaku Nakabeppu

    Cerebral Cortex   24 ( 9 )   2476 - 2488   2014.1

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    DOI: 10.1093/cercor/bht101

  • Response Letter Reviewed

    Mio Ozawa, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara

    Journal of the American Geriatrics Society   62 ( 12 )   2467 - 2468   2014.1

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    DOI: 10.1111/jgs.13163

  • Milk and dairy consumption and risk of dementia in an elderly Japanese population The hisayama study Reviewed

    Mio Ozawa, Tomoyuki Ohara, Toshiharu Ninomiya, Jun Hata, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Kazuhiro Uchida, Tomoko Shirota, Takanari Kitazono, Yutaka Kiyohara

    Journal of the American Geriatrics Society   62 ( 7 )   1224 - 1230   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.12887

  • Corrigendum to "Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease The Hisayama Study" [Atherosclerosis 231 (2) (2013) 261-267] Reviewed

    Toshiharu Ninomiya, Masaharu Nagata, Jun Hata, Yoichiro Hirakawa, Mio Ozawa, Daigo Yoshida, Tomoyuki Ohara, Hiro Kishimoto, Naoko Mukai, Masayo Fukuhara, Takanari Kitazono, Yutaka Kiyohara

    Atherosclerosis   234 ( 2 )   344 - 345   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2014.03.033

  • A case of late-onset bipolar disorder with severely abnormal behavior and neuroimaging observations very similar to those of frontotemporal dementia Reviewed

    Akira Monji, Keisuke Motomura, Yoshito Mizoguchi, Tomoyuki Ohara, Shingo Baba, Takashi Yoshiura, Shigenobu Kanba

    Journal of Neuropsychiatry and Clinical Neurosciences   26 ( 1 )   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1176/appi.neuropsych.13020031

  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease The Hisayama Study Reviewed

    Toshiharu Ninomiya, Masaharu Nagata, Jun Hata, Yoichiro Hirakawa, Mio Ozawa, Daigo Yoshida, Tomoyuki Ohara, Hiro Kishimoto, Naoko Mukai, Masayo Fukuhara, Takanari Kitazono, Yutaka Kiyohara

    Atherosclerosis   231 ( 2 )   261 - 267   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2013.09.023

  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study Reviewed

    Toshiharu Ninomiya, Masaharu Nagata, Jun Hata, Yoichiro Hirakawa, Mio Ozawa, Daigo Yoshida, Tomoyuki Ohara, Hiro Kishimoto, Naoko Mukai, Masayo Fukuhara, Takanari Kitazono, Yutaka Kiyohara

    Atherosclerosis   231 ( 2 )   261 - 267   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2013.09.023

  • Automated measurement of cerebral cortical thickness based on fuzzy membership map derived from MR images for evaluation of Alzheimer's disease

    Hidetaka Arimura, Chiaki Tokunaga, Takashi Yoshiura, Tomoyuki Ohara, Yasuo Yamashita, Fukai Toyofuku

    2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013   7116 - 7119   2013.10

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    Language:English   Publishing type:Research paper (other academic)  

    DOI: 10.1109/EMBC.2013.6611198

  • Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men A cross-sectional study Reviewed

    Atsuko Sekita, Hisatomi Arima, Toshiharu Ninomiya, Tomoyuki Ohara, Yasufumi Doi, Yoichiro Hirakawa, Masayo Fukuhara, Jun Hata, Koji Yonemoto, Yukiko Ga, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara

    BMC Public Health   13 ( 1 )   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-2458-13-862

  • Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Reviewed

    Atsuko Sekita, Hisatomi Arima, Toshiharu Ninomiya, Tomoyuki Ohara, Yasufumi Doi, Yoichiro Hirakawa, Masayo Fukuhara, Jun Hata, Koji Yonemoto, Yukiko Ga, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara

    BMC PUBLIC HEALTH   13   862   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-2458-13-862

  • FTD with catatonia-like signs that temporarily resolved with zolpidem Reviewed

    Shuichi Isomura, Akira Monji, Kensuke Sasaki, Shingo Baba, Toshiaki Onitsuka, Tomoyuki Ohara, Yoshito Mizoguchi, Takahiro Kato, Hideki Horikawa, Yoshihiro Seki, Shigenobu Kanba

    Neurology: Clinical Practice   3 ( 4 )   354 - 357   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/CPJ.0b013e3182a1ba12

  • Dietary patterns and risk of dementia in an elderly Japanese population The hisayama Study1-3 Reviewed

    Mio Ozawa, Toshiharu Ninomiya, Tomoyuki Ohara, Yasufumi Doi, Kazuhiro Uchida, Tomoko Shirota, Koji Yonemoto, Takanari Kitazono, Yutaka Kiyohara

    American Journal of Clinical Nutrition   97 ( 5 )   1076 - 1082   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3945/ajcn.112.045575

  • Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study Reviewed

    Mio Ozawa, Toshiharu Ninomiya, Tomoyuki Ohara, Yasufumi Doi, Kazuhiro Uchida, Tomoko Shirota, Koji Yonemoto, Takanari Kitazono, Yutaka Kiyohara

    AMERICAN JOURNAL OF CLINICAL NUTRITION   97 ( 5 )   1076 - 1082   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3945/ajcn.112.045575

  • Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya, Yoichiro Hirakawa, Kyota Ashikawa, Akira Monji, Yutaka Kiyohara, Shigenobu Kanba, Michiaki Kubo

    PSYCHIATRIC GENETICS   22 ( 6 )   290 - 293   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/YPG.0b013e3283586215

  • Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese The hisayama study Reviewed

    Mio Ozawa, Toshiharu Ninomiya, Tomoyuki Ohara, Yoichiro Hirakawa, Yasufumi Doi, Jun Hata, Kazuhiro Uchida, Tomoko Shirota, Takanari Kitazono, Yutaka Kiyohara

    Journal of the American Geriatrics Society   60 ( 8 )   1515 - 1520   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1532-5415.2012.04061.x

  • 糖尿病と認知症の疫学 : 久山町研究 (特集 糖尿病患者における認知症 : 基礎と臨床の最新知見) -- (疫学)

    小原 知之, 清原 裕

    糖尿病   4 ( 9 )   12 - 20   2012.8

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    Language:Japanese  

  • Self-Reported Dietary Intake of Potassium, Calcium, and Magnesium and Risk of Dementia in the Japanese: The Hisayama Study Reviewed

    Mio Ozawa, Toshiharu Ninomiya, Tomoyuki Ohara, Yoichiro Hirakawa, Yasufumi Doi, Jun Hata, Kazuhiro Uchida, Tomoko Shirota, Takanari Kitazono, Yutaka Kiyohara

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   60 ( 8 )   1515 - 1520   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1532-5415.2012.04061.x

  • Glucose tolerance status and risk of dementia in the community The Hisayama Study Reviewed

    T. Ohara, Y. Doi, T. Ninomiya, Y. Hirakawa, J. Hata, T. Iwaki, S. Kanba, Y. Kiyohara

    NEUROLOGY   77 ( 12 )   1126 - 1134   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Midlife and late-life blood pressure and dementia in japanese elderly The hisayama study Reviewed

    Toshiharu Ninomiya, Tomoyuki Ohara, Yoichiro Hirakawa, Daigo Yoshida, Yasufumi Doi, Jun Hata, Shigenobu Kanba, Toru Iwaki, Yutaka Kiyohara

    Hypertension   58 ( 1 )   22 - 28   2011.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/HYPERTENSIONAHA.110.163055

  • Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly The Hisayama Study Reviewed

    Toshiharu Ninomiya, Tomoyuki Ohara, Yoichiro Hirakawa, Daigo Yoshida, Yasufumi Doi, Jun Hata, Shigenobu Kanba, Toru Iwaki, Yutaka Kiyohara

    HYPERTENSION   58 ( 1 )   22 - U58   2011.7

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    DOI: 10.1161/HYPERTENSIONAHA.110.163055

  • Apolipoprotein Genotype for Prediction of Alzheimer's Disease in Older Japanese: The Hisayama Study Reviewed

    Tomoyuki Ohara, Toshiharu Ninomiya, Michiaki Kubo, Yoichiro Hirakawa, Yasufumi Doi, Jun Hata, Toru Iwaki, Shigenobu Kanba, Yutaka Kiyohara

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   59 ( 6 )   1074 - 1079   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1532-5415.2011.03405.x

  • Interictal psychosis after stroke with forced normalization [6] Reviewed

    Tomoyuki Ohara, Akira Monji, Toshiaki Onitsuka, Toshihiko Maekawa, Yoji Hirano, Shogo Hirano, Sadayuki Hashioka, Takahiro Kato, Ichiro Yoshida, Shigenobu Kanba

    Journal of Neuropsychiatry and Clinical Neurosciences   18 ( 4 )   557 - 559   2006.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1176/appi.neuropsych.18.4.557

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Books

  • 認知症のリスク低減 <医師・看護師のための 認知症プライマリケアまるごとガイド 最新知識に基づくステージアプローチ>

    小原知之( Role: Joint author)

    中央法規出版  2024.3 

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    Language:Japanese   Book type:Scholarly book

  • 軽度認知障害 <医師・看護師のための 認知症プライマリケアまるごとガイド 最新知識に基づくステージアプローチ>

    小原知之( Role: Joint author)

    中央法規出版  2024.3 

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    Language:Japanese   Book type:Scholarly book

  • 精神・心理機能評価ハンドブック 「GDS]

    小原 知之( Role: Joint author)

    2015.6 

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    Language:Japanese   Book type:Scholarly book

  • 血管性認知症の疫学 (特集 老年期精神疾患の臨床像に与える血管障害の影響)

    小原 知之, 清原 裕

    老年精神医学雑誌  2015.1 

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    Responsible for pages:Vol.26, No.1, pp.11-18   Language:Japanese  

  • うつ病の疫学とその課題 (特集 日常診療に役立つうつ病の知識)

    小原 知之, 神庭 重信

    臨牀と研究  2014.5 

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    Responsible for pages:Vol.91, No.5, pp.585-587   Language:Japanese  

  • 最新臨床脳卒中学 (下) (80(増刊2) XXI血管性認知症 1.病態と病因

    小原知之( Role: Sole author)

    日本臨牀社 

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    Language:Japanese   Book type:Scholarly book

  • 精神・神経の治療薬辞典―専門医からのアドバイス 2014-2015<持続性製剤>

    小原 知之

    総合医学社 

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    Language:Japanese   Book type:Scholarly book

  • 精神医学領域の論文を読みこなすキーワード100! 総論 6. 疫学.

    小原知之( Role: Sole author)

    新興医学出版社 

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    Language:Japanese   Book type:Scholarly book

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Presentations

  • 地域高齢者における認知症の実態:久山町研究

    小原知之、二宮利治、神庭重信、清原 裕

    日本生物学的精神医学会  2011.5 

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    Event date: 2011.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 地域住民における耐糖能レベルが認知症発症におよぼす影響:久山町研究

    小原知之,土井康文,二宮利治,谷崎弓裕,秦淳,福原正代、清原裕

    日本老年医学会  2010.6 

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    Event date: 2010.6

    Presentation type:Oral presentation (general)  

    Venue:兵庫県神戸市   Country:Japan  

  • 地域住民における糖尿病/耐糖能異常が認知症発症におよぼす影響:久山町研究

    小原知之,関田敦子,門司 晃,清原 裕,神庭重信

    日本精神神経学会  2010.5 

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    Event date: 2010.5

    Presentation type:Oral presentation (general)  

    Venue:広島県広島市   Country:Japan  

  • 地域一般住民における耐糖能レベルと認知症発症の関係:久山町研究

    小原知之、関田敦子、谷崎弓裕、土井康文、秦淳、二宮利治、清原裕、神庭重信

    日本社会精神医学会  2010.2 

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    Event date: 2010.2

    Presentation type:Oral presentation (general)  

    Venue:島根県松江市   Country:Japan  

  • 血管肉腫の腫瘍塞栓により脳梗塞再発を繰り返した一例

    小原知之、谷崎弓裕、今村剛、土井康文、山口浩、薛宇孝、小田義直、住田英二、恒吉正澄、清原裕

    日本老年医学会九州地方会  2009.3 

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    Event date: 2009.3

    Presentation type:Oral presentation (general)  

    Venue:宮崎県宮崎市   Country:Japan  

  • 糖尿病と認知症の疫学

    小原 知之

    第1回糖尿病と認知症研究会  2013.12 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 久山町研究-生活習慣病と認知症- Invited

    小原 知之, 二宮 利治, 神庭 重信, 清原 裕

    日本認知症学会  2012.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:つくば国際会議場   Country:Japan  

  • 糖尿病と脳血管性認知症:久山町研究 Invited

    小原 知之, 清原 裕

    第27回日本糖尿病合併症学会  2012.11 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:アクロス福岡国際会議場   Country:Japan  

  • 認知症の実態とその治療

    小原 知之

    第35回Primary Health Care研修会  2013.1 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡   Country:Japan  

  • 糖尿病と認知症

    小原 知之

    糖尿病と認知症を考える会  2013.2 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:松山市   Country:Japan  

  • 認知症の危険因子・防御因子 <ワークショップ17>認知症の臨床―予防、診断、治療のコツ―

    小原 知之, 二宮 利治, 神庭 重信, 清原 裕

    第109回日本精神神経学会  2013.5 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 認知症の危険因子・防御因子 Invited

    小原 知之, 二宮 利治, 神庭 重信, 清原 裕

    第109回日本精神神経学会  2013.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡国際会議場   Country:Japan  

  • 認知症の実態とBPSDに対するメマリーの位置づけ

    小原 知之

    第5回東部認知症医療連携勉強会  2013.6 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民におけるうつ状態の実態:久山町研究

    小原 知之, 二宮 利治, 清原 裕, 神庭 重信

    第10回日本うつ病学会  2013.7 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州国際会議場   Country:Japan  

  • 糖尿病と認知症:久山町研究

    小原 知之

    福岡認知症診療を考える会  2013.7 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 生活習慣病と認知症:久山町研究 Invited

    小原 知之, 二宮 利治, 神庭 重信, 清原 裕

    第27回老年期認知症研究会  2013.7 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:コクヨショールーム   Country:Japan  

  • 久山町研究からみた血管性認知症の疫学 Invited

    小原 知之

    第4回血管性認知症外研究会  2013.8 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京カンファレンスセンター品川   Country:Japan  

  • 認知症の有病率:最近の久山研究から

    小原 知之

    第74回福岡認知症研究会  2013.9 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 疫学的視点からみた血管性認知症の危険因子と防御因子

    小原 知之

    2013.10 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • ADL障害と認知症:疫学的視点から

    小原 知之

    2013.10 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 糖尿病と認知症の疫学:久山町研究

    小原 知之

    第2回Fukuoka Life Science研究会  2013.10 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 認知症の治療で必要なもの Invited

    小原知之

    第26回日本臨床脳神経外科学会  2023.7 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 血漿認知症バイオマーカーと認知症発症の関係:地域前向きコホート研究の成績より

    小原知之、秦 淳、徳田隆彦、本田貴紀、柴田舞欧、中路重之、前田哲也、小野賢二郎、三村 將、中島健二、伊賀淳一、竹林 実、二宮利治

    第38回日本老年精神医学会秋季大会  2023.10 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • フレイルや認知症の合併を考慮した不眠症の治療戦略

    小原知之

    第42回日本認知症学会  2023.11 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 認知症の血漿バイオマーカーと認知症発症の関係

    小原知之、二宮利治

    第42回日本認知症学会  2023.11 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 久山町コホートからみた生活習慣病・生活習慣と脳画像との関連

    小原知之、二宮利治

    第42回日本認知症学会  2023.11 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 地域高齢住民における認知症有病率の時代的変化:久山町研究

    小原知之、二宮利治

    第42回日本認知症学会  2023.11 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 安全性に配慮した不眠症の治療に必要なもの Invited

    小原知之

    第74回九州精神神経学会  2022.11 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 認知症の早期発見と診断精度の向上に必要なもの Invited

    小原知之

    第41回日本認知症学会/第37回日本老年精神医学会  2022.11 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 地域高齢住民における認知症の実態とその危険因子:久山町研究

    小原知之、二宮利治

    第118回日本精神神経学会  2022.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知症の危険因子・防御因子.

    小原知之、二宮利治

    第41回日本認知症学会/第37回日本老年精神医学会  2022.11 

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    Event date: 2022.6 - 2023.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知症発症の血液バイオマーカー探索:久山町研究

    小原知之、二宮利治

    第117回日本精神神経学会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都市   Country:Japan  

  • 疫学研究からみた認知症の危険因子・防御因子とその対応

    小原知之、二宮利治

    第63回日本老年医学会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋市   Country:Japan  

  • 慢性腎臓病と認知症 Invited

    小原知之、二宮利治

    第66回日本透析医学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜市   Country:Japan  

  • 糖尿病と認知症の地域疫学研究:久山町研究

    小原知之、二宮利治

    第63回日本老年医学会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋市   Country:Japan  

  • アルツハイマー型認知症の血管性危険因子の検討:久山町研究 Invited

    小原知之、二宮利治

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • WHO ガイドライン「認知機能低下および認知症のリスク軽減」について Invited

    小原知之

    第35回日本老年精神医学会  2020.12 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 安全性を重視した不眠症の治療戦略-高齢者の不眠を中心に- Invited

    小原知之

    第41回日本臨床薬理学会  2020.12 

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    Event date: 2020.12

    Language:Japanese  

    Country:Japan  

  • 久山町研究の知見からみた認知症予防の可能性

    小原知之、二宮利治

    第39回日本認知症学会  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • WHO の予防ガイドラインについて Invited

    小原知之

    第62回日本老年医学会  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知症にどう立ち向かうか:久山町研究 Invited

    小原知之、二宮利治

    第26回日本心臓リハビリテーション学会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 血清sTREM2と認知症発症:久山町研究

    小原 知之, 二宮 利治

    第26回日本未病システム学会  2019.11 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 認知症コホート研究から (1) : 久山町研究 Invited

    小原 知之, 二宮 利治

    第116回日本内科学会  2019.4 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 血清sTREM2と認知症発症の関係:久山町研究

    小原 知之, 二宮 利治

    第34回日本老年精神医学会  2019.6 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 地域高齢住民における認知症の実態とその危険因子:久山町研究 Invited

    小原 知之, 二宮 利治

    第9回認知症予防学会学術集会  2019.10 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 疫学の視点からみた睡眠障害と認知症発症

    小原知之

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 久山町研究からみたアルツハイマー型認知症の血管性危険因子

    小原 知之, 二宮 利治

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 久山町における認知症コホート研究

    小原 知之, 二宮 利治

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 認知症診療のコツ-気づきから予防まで- Invited

    小原 知之

    第68回九州精神神経学会  2015.11 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀市   Country:Japan  

  • 糖尿病と認知症の疫学:久山町研究 Invited

    小原 知之

    第49回糖尿病学の進歩  2015.2 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:岡山市   Country:Japan  

  • 久山町研究からみた認知症予防 Invited

    小原 知之

    第29回日本老年学会総会  2015.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Epidemiology of dementia in an elderly Japanese population: the Hisayama Study Invited International conference

    Tomoyuki Ohara

    9th International Congress of Asian Society Against Dementia  2015.9 

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    Event date: 2016.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 地域高齢住民における認知症の実態と予防:久山町研究 Invited

    小原 知之

    第5回日本認知症予防学会学術集会  2015.9 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Epidemiology of dementia in the community-dwelling Japanese elderly: the Hisayama Study. Invited

    2015.10 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. Invited International conference

    14th Inernational College of Geriatric Psychoneuropharmacology  2014.10 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Epidemiology of senile dementia in Japan. Invited International conference

    5th World Congress of Asian Psychiatry  2015.3 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

▼display all

MISC

  • 疫学_糖尿病と認知症の疫学:久山町研究

    小原知之、清原 裕

    月刊糖尿病   2012.8

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  • 糖尿病は、アルツハイマー病のリスクとなりますか?また、どんな機序が関与しているか教えてください。

    小原 知之、清原 裕

    循環器医から寄せられる「糖尿病と血管合併症」に関する100の質問   2012.5

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  • 認知症の有病率:久山町研究

    小原知之

    TEXT精神医学   2012.4

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  • 認知症の症状とそのケアについて

    小原知之

    福岡市芙蓉会健康講座   2012.3

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  • 糖尿病と認知症

    小原知之、清原裕

    2009.10

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  • わが国における認知症の実態 ‐久山町研究から-

    小原知之、清原裕

    2009.2

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  • 新時代の認知症疫学研究

    小原 知之, 清原 裕

    1900

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  • 糖尿病と脳血管性認知症:久山町研究

    小原 知之

    糖尿病合併症   1900

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  • 入院患者さんの不眠症治療薬はどの様に選択していますか? Reviewed

    小原知之

    臨牀と研究   2023.8

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  • アルツハイマー病の疫学 Reviewed

    小原知之

    臨床精神医学   2023.8

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  • 認知症のリスク低減に関するエビデンス Reviewed

    小原知之

    老年精神医学雑誌   2023.7

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  • 認知機能障害 Reviewed

    小原知之

    日本臨床   2023.6

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  • アルツハイマー型認知症の診断能の向上を目指して Reviewed

    小原知之

    老年精神医学雑誌   2023.4

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  • アルツハイマー型認知症の診断能の向上を目指して Reviewed

    小原知之

    老年精神医学雑誌   2023.2

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  • 軽度認知障害の疫学 Reviewed

    小原知之、三原 茜、中尾智博

    老年精神医学雑誌   2022.12

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  • 久山町研究における認知症の疫学研究 Reviewed

    小原知之、二宮 利治

    精神科   2022.10

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  • 生活習慣病と認知症:久山町研究 Reviewed

    小原 知之, 二宮 利治

    老年期認知症研究会誌   2021.8

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  • 睡眠と認知症の疫学 Reviewed

    小原 知之, 二宮 利治

    精神科臨床Legato   2021.7

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  • アルツハイマー型認知症の血管性危険因子 久山町研究 Reviewed

    小原 知之, 二宮 利治

    2021.5

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  • アルツハイマー病発症の危険因子とそのリスク低減 Reviewed

    小原知之

    医学と薬学   2021.1

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  • :久山町の認知症コホート研究 Reviewed

    小原知之,二宮利治

    2020.11

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  • βアラニン血中濃度と認知症発症の関連 久山町研究

    秦 淳, 小原 知之, 片倉 喜範, 清水 邦義, 山下 俊太郎, 吉田 大悟, 本田 貴紀, 平川 洋一郎, 柴田 舞欧, 坂田 智子, 北園 孝成, 久原 哲, 二宮 利治

    日本未病システム学会学術総会抄録集   2018.10

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  • 血圧変動評価と臓器障害 家庭血圧の日間変動と認知症との関連 久山町研究

    大石 絵美, 小原 知之, 坂田 智子, 福原 正代, 秦 淳, 吉田 大悟, 柴田 舞欧, 大坪 俊夫, 北園 孝成, 清原 裕, 二宮 利治

    日本高血圧学会総会プログラム・抄録集   2018.9

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    Language:Japanese  

  • 高血圧は認知症の成因になりうるのか? 地域高齢住民における臥位高血圧と認知症発症の関連 久山町研究

    坂田 智子, 大石 絵美, 小原 知之, 秦 淳, 大坪 俊夫, 北園 孝成, 二宮 利治

    日本高血圧学会総会プログラム・抄録集   2018.9

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  • 地域高齢住民における認知症の有病率・発症率・予後の時代的変化 久山町研究

    小原 知之, 二宮 利治

    老年期認知症研究会誌   2018.7

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  • 連続剖検例にて神経原線維変化型認知症と診断された認知症例の臨床的特徴 久山町研究

    畑部 暢三, 小原 知之, 本田 裕之, 岩城 徹, 神庭 重信, 二宮 利治

    精神神経学雑誌   2018.6

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    Language:Japanese  

  • 認知症の新規発症を減らすためにできることは何か? 生活習慣病や生活習慣との関連 久山町研究

    小原 知之, 神庭 重信, 二宮 利治

    精神神経学雑誌   2018.6

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  • 地域住民における糖尿病有病率の時代的変化、1988-2012年 久山町研究

    向井 直子, 秦 淳, 平川 洋一郎, 小原 知之, 吉田 大悟, 中村 宇大, 北園 孝成, 二宮 利治

    糖尿病   2018.4

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  • 【実施診療のための最新認知症学-検査・治療・予防・支援-】 認知症予防 久山町研究から考える認知症予防

    小原 知之, 二宮 利治

    日本臨床   2018.1

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  • 地域在住非糖尿病者における座位時間とインスリン抵抗性の関連 久山町研究

    本田 貴紀, 岸本 裕歩, 向井 直子, 秦 淳, 吉田 大悟, 平川 洋一郎, 柴田 舞欧, 小原 知之, 熊谷 秋三, 二宮 利治

    日本未病システム学会学術総会抄録集   2017.10

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  • 地域高齢者における中年期から老年期の握力低下と認知症発症の関連 久山町研究

    畑部 暢三, 柴田 舞欧, 小原 知之, 大石 絵美, 岸本 裕歩, 本田 貴紀, 吉田 大悟, 秦 淳, 神庭 重信, 二宮 利治

    2017.10

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  • 地域高齢者における中年期から老年期までの握力変化と認知症発症の関連 久山町研究

    畑部 暢三, 柴田 舞欧, 小原 知之, 大石 絵美, 岸本 裕歩, 本田 貴紀, 吉田 大悟, 秦 淳, 神庭 重信, 二宮 利治

    日本未病システム学会学術総会抄録集   2017.10

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  • 老年期の脂肪量および除脂肪体重が認知症発症におよぼす影響 久山町研究

    小原 知之, 神庭 重信, 二宮 利治

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集   2017.9

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  • 久山町研究からみた認知症の予防

    小原 知之, 清原 裕, 二宮 利治

    老年期認知症研究会誌   2017.7

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  • 地域住民におけるNT-proBNPの変化率と総死亡および死因別死亡との関連 久山町研究

    梅原 薫, 平川 洋一郎, 秦 淳, 向井 直子, 小原 知之, 吉田 大悟, 岸本 裕歩, 北園 孝成, 外 須美夫, 清原 裕, 二宮 利治

    日本循環器病予防学会誌   2017.5

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  • 地域住民における血糖関連指標とアルツハイマー病発症との関連 久山町研究

    向井 直子, 小原 知之, 秦 淳, 平川 洋一郎, 吉田 大悟, 岸本 裕歩, 古賀 正史, 中村 宇大, 北園 孝成, 清原 裕, 二宮 利治

    糖尿病   2017.4

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  • 剖検にて神経原線維変化型認知症が判明した老年期認知症の1例

    畑部 暢三, 小原 知之, 秦 淳, 橋迫 美貴子, 小田 義直, 本田 裕之, 北園 孝成, 清原 裕, 二宮 利治

    日本老年医学会雑誌   2016.10

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  • 未病予防の幹となる生活のなかの運動の包括的位置づけ 地域住民における運動と生活習慣病の疫学 久山町研究

    岸本 裕歩, 秦 淳, 小原 知之, 吉田 大悟, 二宮 利治

    日本未病システム学会学術総会抄録集   2016.10

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  • 未病と認知症の一次予防 福岡県久山町における認知症の疫学 久山町研究

    小原 知之, 二宮 利治

    日本未病システム学会学術総会抄録集   2016.10

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  • 地域高齢者における歯の喪失が認知症発症に及ぼす影響の検討 久山町研究

    竹内 研時, 古田 美智子, 山下 喜久, 二宮 利治, 小原 知之

    日本公衆衛生学会総会抄録集   2016.10

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  • 地域高齢住民における微小脳出血の有病率とその危険因子 久山町研究

    由比 智裕, 秦 淳, 向井 直子, 小原 知之, 平林 直樹, 古田 芳彦, 吾郷 哲朗, 北園 孝成, 清原 裕, 二宮 利治

    日本未病システム学会学術総会抄録集   2016.10

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  • 地域住民における座位時間と糖尿病の関連 久山町研究

    本田 貴紀, 岸本 裕歩, 向井 直子, 秦 淳, 吉田 大悟, 平川 洋一郎, 柴田 舞欧, 小原 知之, 熊谷 秋三, 清原 裕, 二宮 利治

    日本未病システム学会学術総会抄録集   2016.10

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  • Epidemiology of diabetes and risk of Dementia Reviewed

    Tomoyuki Ohara

    Brain and Nerve   2016.7

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  • 【アルツハイマー型認知症診療のBreakthrough】 生活習慣病とアルツハイマー型認知症

    小原 知之, 二宮 利治

    2016.7

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  • 一般住民におけるアルブミン尿と認知症発症の関係 久山町研究

    高江 啓太, 永田 雅治, 小原 知之, 秦 淳, 鶴屋 和彦, 北園 孝成, 清原 裕, 二宮 利治

    日本腎臓学会誌   2016.5

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  • 地域高齢者における野菜・果実の摂取と認知機能の関係 久山町研究

    吉田 大悟, 津野崎 希, 小原 知之, 岸本 裕歩, 秦 淳, 柴田 舞欧, 向井 直子, 北園 孝成, 清原 裕, 二宮 利治

    日本老年医学会雑誌   2016.5

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  • 【認知症】 疫学 Alzheimer病の危険因子・防御因子

    小原 知之, 二宮 利治, 清原 裕

    最新医学   2016.3

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    Alzheimer病(AD)は加齢と密接に関連する神経変性疾患である.久山町研究を含む国内外の追跡調査の成績によると,アポリポタンパクE(APOE-ε4),糖尿病,喫煙,うつ症状はAD発症の有意な危険因子であった.一方,運動および和食+野菜+牛乳・乳製品という食事パターンとAD発症の間に,有意な負の関連が存在した.つまり,加齢や遺伝的要因に基づくADのリスクは,生活習慣病の予防や生活習慣の是正によって軽減できる可能性がある.(著者抄録)

  • 【認知症の早期発見と予防・治療-認知症500万人時代に求められるもの】 ライフスタイルと認知症

    小原 知之, 二宮 利治

    カレントテラピー   2016.3

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  • 運動疫学研究の今とこれから 久山町研究における運動疫学

    岸本 裕歩, 秦 淳, 小原 知之, 清原 裕, 二宮 利治

    体力科学   2016.2

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    DOI: 10.7600/jspfsm.65.50

  • 生活習慣病と認知症

    小原 知之

    臨牀と研究   2016.1

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  • 【生活習慣病-新しい展開】 見直された生活習慣病と疾患 生活習慣病と認知症

    小原 知之, 二宮 利治

    臨牀と研究   2016.1

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  • これからの認知症治療を考える(基礎・臨床) 家庭血圧の日間変動と認知症発症との関連 久山町研究

    大石 絵美, 小原 知之, 福原 正代, 坂田 智子, 秦 淳, 大坪 俊夫, 松村 潔, 北園 孝成, 清原 裕, 二宮 利治

    日本高血圧学会総会プログラム・抄録集   2015.10

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  • 地域高齢住民における認知症の疫学 久山町研究

    小原 知之, 清原 裕, 二宮 利治

    日本高血圧学会総会プログラム・抄録集   2015.10

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  • 地域高齢者における糖尿病と頭部MRI上の海馬萎縮との関係 久山町研究

    平林 直樹, 秦 淳, 小原 知之, 向井 直子, 永田 雅治, 柴田 舞欧, 後藤 聖司, 古田 芳彦, 山下 典生, 吉原 一文, 北園 孝成, 須藤 信行, 清原 裕, 二宮 利治

    日本未病システム学会学術総会抄録集   2015.9

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  • [特集]認知症疾患医療センターがリードする認知症への包括ケア 鼎談 機動力のある認知症疾患医療センターを目指す

    小原 知之

    2015.8

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  • 血管性認知症の疫学

    小原 知之

    2015.6

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  • 握力の経年変化が総死亡および死因別死亡に与える影響 久山町研究

    岸本 裕歩, 秦 淳, 吉田 大悟, 池田 文恵, 向井 直子, 永田 雅治, 小原 知之, 二宮 利治, 北園 孝成, 清原 裕

    日本循環器病予防学会誌   2015.6

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  • 地域高齢住民における認知症発症率の時代的変化とその要因の検討 久山町研究

    小原 知之, 二宮 利治, 秦 淳, 吉田 大悟, 向井 直子, 永田 雅治, 岸本 裕歩, 北園 孝成, 神庭 重信, 清原 裕

    老年精神医学雑誌   2015.5

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  • 地域高齢者における乳・乳製品摂取が生活機能障害と日常生活動作障害の発生に及ぼす影響 久山町研究

    吉田 大悟, 二宮 利治, 小原 知之, 岸本 裕歩, 秦 淳, 福原 正代, 永田 雅治, 北園 孝成, 清原 裕

    日本老年医学会雑誌   2015.5

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  • Response Letter

    Mio Ozawa, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara

    Journal of the American Geriatrics Society   2014.12

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    DOI: 10.1111/jgs.13163

  • 歯周病・糖尿病・アルツハイマー病の負のスパイラルを断ち切る 口腔からの健康寿命延伸戦略 アルツハイマー病脳における糖尿病関連遺伝子の発現異常とその意義 久山町研究

    外間 政朗, 岡 素雅子, Leon Julio, 二宮 利治, 本田 裕之, 佐々木 健介, 岩城 徹, 小原 知之, 清原 裕, 中別府 雄作

    2014.9

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  • 地域住民におけるヘマトクリットレベルが心血管病発症に及ぼす影響 久山町研究

    後藤 聖司, 秦 淳, 二宮 利治, 福原 正代, 永田 雅治, 向井 直子, 池田 文恵, 小原 知之, 吉田 大悟, 岸本 裕歩, 吾郷 哲朗, 北園 孝成, 清原 裕

    日本循環器病予防学会誌   2014.7

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  • 地域住民におけるヘモグロビンA1cレベルと心血管病発症の関係 久山町研究

    池田 文恵, 秦 淳, 二宮 利治, 福原 正代, 向井 直子, 永田 雅治, 小原 知之, 吉田 大悟, 岸本 裕歩, 北園 孝成, 清原 裕

    日本循環器病予防学会誌   2014.7

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  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study (Vol 231, pg 261, 2013)

    Toshiharu Ninomiya, Masaharu Nagata, Jun Hata, Yoichiro Hirakawa, Mio Ozawa, Daigo Yoshida, Tomoyuki Ohara, Hiro Kishimoto, Naoko Mukai, Masayo Fukuhara, Takanari Kitazono, Yutaka Kiyohara

    ATHEROSCLEROSIS   2014.6

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    DOI: 10.1016/j.atherosclerosis.2014.03.033

  • 地域高齢住民における食事パターンが認知症発症に与える影響 久山町研究

    小澤 未央, 二宮 利治, 小原 知之, 秦 淳, 内田 和宏, 城田 知子, 清原 裕

    日本未病システム学会学術総会抄録集   2013.10

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  • 蛋白質エネルギー比率と脳卒中発症との関連 久山町研究

    小澤 未央, 二宮 利治, 秦 淳, 小原 知之, 平川 洋一郎, 福原 正代, 内田 和宏, 城田 知子, 北園 孝成, 清原 裕

    日本循環器病予防学会誌   2013.5

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  • わが国の地域一般住民における耐糖能レベルと認知症発症リスク : 久山町研究

    小原 知之

    精神神經學雜誌 = Psychiatria et neurologia Japonica   2013.1

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  • わが国において継続中の認知症疫学研究 久山町研究 生活習慣病と認知症

    小原 知之, 二宮 利治, 神庭 重信, 清原 裕

    2012.10

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  • 生活習慣病と認知症 久山町研究

    小原 知之, 二宮 利治, 神庭 重信, 清原 裕

    老年期認知症研究会誌   2012.8

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  • 地域住民における乳・乳製品の摂取量と認知症発症との関連 久山町研究

    小澤 未央, 小原 知之, 二宮 利治, 内田 和宏, 福原 正代, 清原 裕

    日本老年医学会雑誌   2012.5

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  • 地域高齢者が生涯に認知症を発症する確率の検討 久山町研究

    二宮 利治, 小原 知之, 福原 正代, 神庭 重信, 北園 孝成, 清原 裕

    日本老年医学会雑誌   2012.5

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  • 定期的な運動習慣が認知症発症に及ぼす影響 久山町研究

    野藤 悠, 岸本 裕歩, 小原 知之, 二宮 利治, 熊谷 秋三, 清原 裕

    体力科学   2011.12

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  • 地域一般住民におけるカルシウム、マグネシウム、カリウムの摂取量と認知症発症の関連 久山町研究

    小澤 未央, 二宮 利治, 小原 知之, 内田 和宏, 福原 正代, 清原 裕

    日本老年医学会雑誌   2011.5

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  • 地域一般住民における耐糖能レベルと認知症発症の関係 久山町研究

    小原 知之, 関田 敦子, 谷崎 弓裕, 土井 康文, 秦 淳, 二宮 利治, 清原 裕, 神庭 重信

    日本社会精神医学会雑誌   2010.7

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  • 地域住民における耐糖能レベルが認知症発症におよぼす影響 久山町研究

    小原 知之, 土井 康文, 二宮 利治, 谷崎 弓裕, 秦 淳, 福原 正代, 清原 裕

    日本老年医学会雑誌   2010.5

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Professional Memberships

  • 九州精神神経学会

  • 日本児童青年精神医学会

  • 日本生物学的精神医学会

  • 日本老年医学会

  • 日本精神神経学会

Academic Activities

  • Psychogeriatrics International contribution

    2022.10 - 2030.4

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  • Psychiatry and Clinical Nerurosciences International contribution

    2021.4 - 2025.3

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    Type:Academic society, research group, etc. 

  • シンポジウム

    第4回血管性認知症外研究会  ( 東京カンファレンスセンター品川 ) 2013.8

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  • 地区推薦

    第27回老年期認知症研究会  ( コクヨショールーム ) 2013.7

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  • 司会(Moderator)

    第109回日本精神神経学会  ( 福岡国際会議場 ) 2013.5 - 2013.8

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  • ワークショップ

    第109回日本精神神経学会  ( 福岡国際会議場 ) 2013.5

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  • シンポジウム

    第27回糖尿病合併症学会  ( アクロス福岡国際会議場 ) 2012.11

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  • シンポジウム

    第31回日本認知症学会  ( つくば国際会議場 ) 2012.10

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  • シンポジウム、演者

    日本生物学的精神医学会  ( 東京都 ) 2011.5 - 2011.10

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Research Projects

  • アルツハイマー病疾患修飾薬全国臨床レジストリーの構築と解析

    2024.4 - 2026.3

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    Authorship:Coinvestigator(s) 

  • 認知症予防に関わる民間ソリューション(非薬物的アプローチ)の効果検証および質の評価の在り方に関する検討会

    2021.12 - 2023.3

    日本総研 

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    Authorship:Coinvestigator(s) 

  • 大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究

    2021.4 - 2026.3

    九州大学 

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    Authorship:Coinvestigator(s) 

    全国8カ所の地域高齢住民を対象に生活習慣病・生活習慣・脳画像・ゲノムと認知症発症の関係を検討する

  • 久山町高齢住民における認知症の実態とその時代的変化の解明に関する横断・縦断研究

    2021.4 - 2024.3

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    Authorship:Principal investigator 

    久山町地域住民の疫学調査の成績を用いて、認知症者の有病率・発症率・予後の時代的変化と認知症発症の危険因子を明らかにすることを目的とする

  • 久山町高齢住民における認知症の実態とその時代的変化の解明に関する横断・縦断研究

    Grant number:21K07522  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 久山町高齢住民における認知症の実態とその時代的変化の解明に関する横断・縦断研究

    Grant number:2 1 K 0 7 5 2 2  2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 認知症に関する血液・髄液バイオマーカーの適正使用のための研究

    2019.4 - 2021.3

    厚生労働科学研究 

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    Authorship:Coinvestigator(s) 

    認知症バイオマーカーの適正使用のあり方を検討する

  • 海外認知症予防ガイドラインの整理に関する調査研究

    2019.4 - 2020.3

    厚生労働省老人保健健康増進等事業 

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    Authorship:Coinvestigator(s) 

    WHO認知症予防ガイドラインの翻訳と注釈作成

  • 久山町高齢住民における認知症の実態解明に関する横断・縦断研究

    2018.4 - 2021.3

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    Authorship:Principal investigator 

  • 久山町高齢住民における認知症の実態解明に関する横断・縦断研究

    Grant number:1 8 K 0 7 5 6 5  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    2017.4 - 2021.3

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    Authorship:Coinvestigator(s) 

  • 健康長寿社会の実現を目指した大規模認知症コホート研究の創設

    2015.9 - 2016.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 久山町高齢住民における認知症の実態とその危険因子・防御因子の解明に関する縦断研究

    2015.4 - 2018.3

    九州大学 

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    Authorship:Principal investigator 

  • 久山町高齢住民における認知症の実態とその危険因子・防御因子の解明に関する縦断研究

    Grant number:15K09835  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大規模ゲノム疫学共同研究による認知症の危険因子および防御因子の解明

    2013.4 - 2016.3

    九州大学 理化学研究所・統合生命医科学研究センター 筑波大学 金沢医科大学 東北大学 鳥取大学 

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    Authorship:Coinvestigator(s) 

    わが国で進行中の主な認知症の疫学研究を統合するとともに、それに認知症のリスクが高い脳卒中患者および糖尿病患者のコホート研究を加えて大規模ゲノム疫学共同研究を組織し、日本人の認知症の危険因子および防御因子を明らかにする。

  • 地域高齢住民におけるうつ病の実態とその危険因子の解明に関する横断・縦断研究

    2012.4 - 2017.3

    九州大学大学院医学研究院 精神病態医学 九州大学大学院医学研究院 環境医学 

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    Authorship:Principal investigator 

  • 地域高齢住民におけるうつ病の実態とその危険因子の解明に関する横断・縦断研究

    Grant number:24591720  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アルツハイマー病の危険因子の解明と予防に関する大規模ゲノム疫学研究

    2008.4 - 2013.3

    厚生労働省 

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Class subject

  • 心身医学・精神医学概論

    2024.4 - 2024.9   First semester

  • 臨床精神医学特論

    2024.4 - 2024.9   First semester

  • 精神保健・疾病論

    2024.4 - 2024.9   First semester

  • 精神保健・疾病論

    2023.4 - 2023.9   First semester

  • 臨床精神医学特論

    2023.4 - 2023.9   First semester

  • 心身医学・精神医学概論

    2023.4 - 2023.9   First semester

  • 衛生・公衆衛生学

    2022.10 - 2023.3   Second semester

  • 臨床精神医学特論

    2022.4 - 2022.9   First semester

  • 衛生・公衆衛生学

    2022.4 - 2022.9   First semester

  • 精神保健・疾病論

    2022.4 - 2022.9   First semester

  • 心身医学・精神医学概論

    2022.4 - 2022.9   First semester

  • 臨床精神医学特論

    2022.4 - 2022.9   First semester

  • 精神保健・疾病論

    2022.4 - 2022.9   First semester

  • 心身医学・精神医学概論

    2022.4 - 2022.9   First semester

  • 衛生・公衆衛生学

    2021.10 - 2022.3   Second semester

  • 心身医学・精神医学概論

    2021.4 - 2021.9   First semester

  • 精神保健・疾病論

    2021.4 - 2021.9   First semester

  • 臨床精神医学特論

    2021.4 - 2021.9   First semester

  • 臨床精神医学特論

    2020.10 - 2021.3   Second semester

  • 衛生・公衆衛生学

    2020.10 - 2021.3   Second semester

  • 心身医学・精神医学概論

    2020.4 - 2020.9   First semester

  • 精神保健・疾病論

    2020.4 - 2020.9   First semester

  • 臨床精神医学特論

    2019.10 - 2020.3   Second semester

  • 心身医学・精神医学概論

    2019.4 - 2019.9   First semester

  • 精神保健・疾病論

    2019.4 - 2019.9   First semester

  • 心身医学・精神医学概論

    2016.4 - 2016.9   First semester

  • 臨床精神医学特論

    2015.10 - 2016.3   Second semester

  • 心身医学・精神医学概論

    2015.4 - 2015.9   First semester

  • 精神保健・疾病論

    2015.4 - 2015.9   First semester

  • 心身医学・精神医学概論

    2015.4 - 2015.9   First semester

  • 臨床精神医学特論

    2014.4 - 2014.9   First semester

  • 心身医学・精神医学概論

    2014.4 - 2014.9   First semester

  • 精神医学

    2013.4 - 2013.9   First semester

  • 心身医学・精神医学概論

    2013.4 - 2013.9   First semester

  • 精神保健・疾病論

    2013.4 - 2013.9   First semester

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2020  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2017  名古屋市立大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

Social Activities

  • 認知症について学ぼう

    令和5年度九州大学基金相続・遺産セミナー「今から考える相続対策」  大阪府  2023.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症に負けない -認知症のリスク低減に必要なもの-

    令和4年度オレンジ健康フェスタ  久留米市  2023.2

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 認知機能低下をいかに見極めるか

    専門訴訟事件等の特殊事件のための研究会、福岡高等裁判所  福岡市  2015.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Research consultation

  • 認知症をいかに予防するか-久山町研究からのメッセージ-

    九州工業大学、福岡教育大学、九州大学主催市民シンポジウム 高齢化社会に向けた課題への大学の取り組み-認知症予防に関する最新研究などの紹介-  福岡市  2015.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 急増する認知症にどのように立ち向かうか?

    朝倉市健康づくり推進員研修会  朝倉市  2015.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 認知症のヒトに適切なケアを提供するために

    福岡市介護保険事業者研修  福岡市  2015.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症とともに生きる-認知症の症状から予防まで-

    第12回アジアメディカルショー  福岡市  2015.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 生活習慣病と認知症:久山研究

    第7回香川県認知症疾患医療センター研修会  2015.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 認知症はこわくない -正しい知識を持って対応しよう-.

    ひさやま健康セミナー~今日からできる健康づくり~  久山町  2015.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 認知症の実態とその支援

    平成25年度福岡市介護保険事業研修  福岡市  2013.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 疫学的視点からみた認知症の危険因子・防御因子

    早良区薬剤師会研修会  福岡市  2013.9

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • もの忘れ講習会

    南ヶ丘地域健康教室  北九州市  2013.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症の診断基準って?お医者さんはどうやって認知症の診断をしているの??

    福岡市介護実習普及センターフェスタ  福岡市  2013.2

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症の医学的知識とその支援

    糟屋地区ケアマネージャーネットワーク全体研修会  糟屋郡  2013.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症の医学的知識とその支援

    糟屋地区ケアマネージャーネットワーク全体研修会  糟屋郡  2013.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症の危険因子・防御因子

    椿ヶ丘荘勉強会  長崎市  2012.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症を正しく学ぶ

    日本赤十字社 やすらぎの郷  やすらぎの郷  2012.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症の基本的知識

    南ヶ丘地区老人会  南ヶ丘公民館  2012.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症の医学的知識

    認知症キャラバンメイト  糟屋区医師会館  2012.2

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 若年性認知症の医学的知識

    福岡市  福岡市市民福祉プラザ  2012.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

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Media Coverage

  • 認知症キャンペーン「認知症と生活習慣」 TV or radio program

    2015.5

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    認知症キャンペーン「認知症と生活習慣」

  • 認知症キャンペーン「要注意!認知症と生活習慣病」 TV or radio program

    2015.5

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    認知症キャンペーン「要注意!認知症と生活習慣病」

  • 「チョイス@病気になったとき」認知症予防スペシャル TV or radio program

    2015.1

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    「チョイス@病気になったとき」認知症予防スペシャル

  • 喫煙と認知症発症の関係について Newspaper, magazine

    朝日新聞、西日本新聞、読売新聞  2014.6

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    喫煙と認知症発症の関係について

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Psychiatry and Neuroscience

Clinician qualification

  • 精神保健指定医

    厚生労働省

  • Specialist

    The Japanese Society of Psychiatry and Neurology(JSPN)

  • Specialist

    Japanese Psychogeriatric Society

Year of medical license acquisition

  • 2003

Notable Clinical Activities

  • 福岡市認知症疾患医療センターとしての認知症診療