Updated on 2024/11/28

Information

 

写真a

 
MURAYAMA KEITARO
 
Organization
Kyushu University Hospital Neuro-Psychiatry Lecturer
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Title
Lecturer
Profile
強迫症および強迫関連症に関する治療ならびに生物学的病態の研究を行っている。 2020年度からはCOVID-19に関連したメンタルヘルスの研究を実施している。
External link

Degree

  • Ph.D.

Research Interests・Research Keywords

  • Research theme:psychiatric symptom after COVID-19

    Keyword:post COVID-19 condition, mental health, psychological first aid

    Research period: 2022.4 - 2025.3

  • Research theme:Biophysiology of Obsessive-Compulsive Disorder

    Keyword:Obsessive-Compulsive Disorder

    Research period: 2018.4 - 2021.3

  • Research theme:Biophysiology of Obsessive-Compulsive Disorder

    Keyword:Obsessive-Compulsive Disorder

    Research period: 2017.4 - 2018.3

  • Research theme:Biophysiology of Obsessive-Compulsive Disorder

    Keyword:Obsessive-Compulsive Disorder

    Research period: 2016.4 - 2017.3

  • Research theme:Biophysiology of Obsessive-Compulsive Disorder

    Keyword:Obsessive-Compulsive Disorder

    Research period: 2010.4 - 2015.6

Awards

  • 2023年度日本認知・行動療法学会 内山記念賞

    2023.10   日本認知・行動療法学会  

  • 第4回日本不安症学会学術大会若手演題優秀賞

    2012.2   日本不安症学会  

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    強迫性障害における症状亜型の違いに関連する神経基盤の違いについてfMRIを用いて調査した。

Papers

  • Aberrant resting-state cerebellar-cerebral functional connectivity in unmedicated patients with obsessive-compulsive disorder Reviewed International journal

    Murayama K, Tomiyama H, Tsuruta S, Ohono A, Kang M, Hasuzawa S, Mizobe T, Kato K, Togao O, Hiwatashi A, Nakao T

    Frontiers in Psychiatry   23 ( 12 )   2021.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fpsy.2021.659616

  • Impacts of Stressful Life Events and Traumatic Experiences on Onset of Obsessive-Compulsive Disorder. Reviewed International journal

    Keitaro Murayama, Tomohiro Nakao, Aikana Ohono, Sae Tsuruta, Hirofumi Tomiyama, Suguru Hasuzawa, Taro Mizobe, Kenta Kato and Sigenobu Kanba

    Frontiers in Psychiatry   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder. Reviewed International journal

    Keitaro Murayama, Tomohiro Nakao, Sanematsu Hirokuni, Kayo Okada, Takashi Yoshiura, Mayumi Tomita, Yusuke Masuda, Kayoko Isomura, Akiko Nakagawa, Shigenobu Kanba

    Progess in Neuropsychopharmacolgy & Biological Psychiatry   10 ( 40 )   160 - 166   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Gender differences and mental distress during COVID-19: a cross-sectional study in Japan

    Kanata, T; Takeda, K; Fujii, T; Iwata, R; Hiyoshi, F; Iijima, Y; Nakao, T; Murayama, K; Watanabe, K; Kikuchi, T; Mimura, M; Yoshimi, A; Hishimoto, A; Hirata, H; Ozaki, N; Kito, S; Kuga, H; Oba, M; Oi, H; Nakagome, K

    BMC PSYCHIATRY   24 ( 1 )   776   2024.11   eISSN:1471-244X

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    Language:English   Publisher:BMC Psychiatry  

    Background: To identify risk factors for mental distress and investigate whether the factors were different between men and women during the coronavirus disease 2019 (COVID-19), using KOKOROBO data, which is an online platform that aims to facilitate access to mental health services. Methods: We used baseline data on KOKOROBO users 13 years of age or older in Japan who accessed it from October 11, 2021, to April 6, 2023, excluding those receiving treatment for mental health problems. Global severity, based on the most severe measure on Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Insomnia Severity Index (ISI), was analyzed using multivariable logistic regression with baseline characteristics for each gender, and for under 30 and 30 years of age or older in women. We conducted the same analysis of suicidal ideation for each gender. Results: In the 686 men and 1274 women, 117 (17.1%) and 100 (7.8%) had minimal global severity respectively, and the rest suffered from mental distress to some extent. For women, ages under 30 years (adjusted OR (aOR): 0.352, 95%CI: 0.231–0.539, P < 0.001), marriage (aOR: 0.453, 95%CI: 0.274–0.746, P = 0.002), and concerns about COVID-19 infection were associated with global severity, while having children (aOR: 0.509, 95% CI: 0.284–0.909, P = 0.023) and decrease of going out during the COVID-19 pandemic had a protective effect on global severity and suicidal ideation for men, respectively. Living with family was a risk factor for mental distress in unmarried women over 30 years of age. Less communication with family or others and responding to the questionnaire late at night (00:00–05:59) were associated with severe global severity in both genders. Conclusions: Age, living arrangement, marriage, having children, concerns about COVID-19 infection, and lifestyle changes during the COVID-19 pandemic had gender-specific effects on mental distress, while frequent communication and regular life rhythm maintained mental health in both genders. Young women and, unmarried middle-aged women living with their families tended to experience mental distress during the COVID-19 pandemic. Trial registration: The Ethics Committee of the National Center of Neurology and Psychiatry approved this study (approval number B2020141) on April 15, 2021.

    DOI: 10.1186/s12888-024-06200-5

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  • No significant alteration in white matter microstructure in first-degree relatives of patients with obsessive-compulsive disorder

    Tomiyama, H; Murayama, K; Nemoto, K; Kato, K; Matsuo, A; Kang, MG; Sashikata, K; Togao, O; Nakao, T

    PSYCHIATRY RESEARCH-NEUROIMAGING   344   111884   2024.10   ISSN:0925-4927 eISSN:1872-7506

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    Language:English   Publisher:Psychiatry Research - Neuroimaging  

    Obsessive-compulsive disorder (OCD) is characterized by structural alteration within white matter tissues of cortico-striato-thalamo-cortical, temporal and occipital circuits. However, the presence of microstructural changes in the white matter tracts of unaffected first-degree relatives of patients with OCD as a vulnerability marker remains unclear. Therefore, here, diffusion-tensor magnetic resonance imaging (DTI) data were obtained from 29 first-degree relatives of patients with OCD and 59 healthy controls. We investigated the group differences in FA using whole-brain analysis (DTI analysis). For additional regions of interest (ROI) analysis, we focused on the posterior thalamic radiation and sagittal stratum, shown in recent meta-analysis of patients with OCD. In both whole-brain and ROI analyses, using a strict statistical threshold (family-wise error rate [FWE] corrected p<.05 for whole-brain analyses, and p<.0125 (0.05/4) with Bonferroni correction for ROI analyses), we found no significant group differences in FA. Subtle reductions were observed in the anterior corona radiata, forceps minor, cingulum bundle, and corpus callosum only when a lenient statistical was applied (FWE corrected p<.20). These findings suggest that alterations in the white matter microstructure of first-degree relatives, as potential vulnerability markers for OCD, are likely subtle.

    DOI: 10.1016/j.pscychresns.2024.111884

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  • Psychological treatments for mental health symptoms associated with COVID-19 infection: A scoping review

    Sugita, S; Hata, K; Kodaiarasu, K; Takamatsu, N; Kimura, K; Miller, C; Gonzalez, L; Umemoto, I; Murayama, K; Nakao, T; Kito, S; Ito, M; Kuga, H

    PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS   3 ( 3 )   e223   2024.9   ISSN:2769-2558

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    Language:English   Publisher:Psychiatry and Clinical Neurosciences Reports  

    The aim of this scoping review was to synthesize published studies and ongoing clinical trials of psychological interventions for mental health problems associated with COVID-19 infection. The study protocol was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. We conducted systematic searches for studies published or registered between January 2020 and October 2022 using eight scientific databases and clinical trial registries, which identified 40 complete published studies and 53 ongoing clinical trials. We found that most studies were randomized controlled trials (74%) while the remaining used study designs of lower methodological quality. Most studies investigated interventions for acute COVID-19 patients (74%) and others explored post-COVID conditions (PCC) or recovered patients. Cognitive and behavioral therapies were the main intervention approaches (31%), followed by multidisciplinary programs (21%) and mindfulness (17%). The most frequently evaluated outcomes were anxiety (33%), depression (26%), quality of life (13%), and insomnia (10%). No studies on youths, older people, or marginalized communities were found. These findings summarize the burgeoning research on a range of psychological interventions for individuals infected with COVID-19. However, the field is in its infancy and further research to develop an evidence base for targeted care is necessary. The gaps identified in the current study also highlight the need for more research on youths, older people, and members of marginalized communities, and PCC patients. It is important to ascertain interventions and delivery strategies that are not only effective and affordable but also allow high scalability and accessibility.

    DOI: 10.1002/pcn5.223

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  • Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder

    Kato, K; Tomiyama, H; Murayama, K; Mizobe, T; Matsuo, A; Nishida, N; Matukuma, K; Kang, MG; Sashikata, K; Kikuchi, K; Togao, O; Nakao, T

    FRONTIERS IN PSYCHIATRY   15   1399062   2024.6   ISSN:1664-0640

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    Language:English   Publisher:Frontiers in Psychiatry  

    Background: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear. Methods: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels. Results: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms. Conclusions: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.

    DOI: 10.3389/fpsyt.2024.1399062

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  • Incidence of post-COVID psychiatric disorders according to the periods of SARS-CoV-2 variant dominance: The LIFE study

    Murata, F; Maeda, M; Murayama, K; Nakao, T; Fukuda, H

    JOURNAL OF PSYCHIATRIC RESEARCH   174   12 - 18   2024.6   ISSN:0022-3956 eISSN:1879-1379

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    Language:English   Publisher:Journal of Psychiatric Research  

    This retrospective cohort study examined the incidence of post-COVID psychiatric disorders in older adults according to hospitalization status and SARS-CoV-2 variant period in Japan. Claims data, COVID-19 case-related information, and vaccination records were obtained from three Japanese municipalities. We identified individuals aged ≥65 years who had COVID-19 or other respiratory tract infection (RTI) between March 2021 and December 2022. Participants were categorized into non-hospitalized and hospitalized patients, and the study period was divided into the Alpha (March to May 2021), Delta (June to December 2021), Omicron BA.1/BA.2 (January to June 2022), and Omicron BA.5 (July to December 2022) periods. Modified Poisson regression analyses were performed to estimate the incidence rate ratios (IRRs) for the occurrence of psychiatric disorders (organic mental disorders, psychotic disorders, mood disorders, anxiety disorders, and insomnia) three months after COVID-19 (reference: other RTI). For overall psychiatric disorders, we analyzed 19,489 non-hospitalized patients (COVID-19: 6,728, Other RTI: 12,761) and 2925 hospitalized patients (COVID-19: 1,036, Other RTI: 1889). When compared with other RTI cases, COVID-19 cases had significantly lower IRRs for overall psychiatric disorders in both non-hospitalized (IRR: 0.59, P < 0.001) and hospitalized cases (IRR: 0. 83, P = 0.045) during the Omicron BA.1/BA.2 period, but only in non-hospitalized cases (IRR: 0.45, P < 0.001) during the Omicron BA.5 period. The incidences of the individual post-COVID psychiatric disorders varied according to disorder type, hospitalization status, and SARS-CoV-2 variant period. These findings provide a foundation for further research to explore these variations and improve the provision of psychiatric care in future epidemics.

    DOI: 10.1016/j.jpsychires.2024.04.010

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  • 特集 よくわかる! 精神疾患対応 これ1冊-内科医と精神科医の連携のために 第4部 知っておきたい精神疾患 各論2:不安症・強迫症・ストレス性疾患 4 強迫症

    村山 桂太郎, 中尾 智博

    診断と治療   112 ( 13 )   159 - 161   2024.3   ISSN:0370999X

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    Publisher:診断と治療社  

    DOI: 10.34433/dt.0000000674

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  • Associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough SARS-CoV-2 infection: The VENUS Study. Invited Reviewed International journal

    Murata F, Maeda M, Murayama K, Nakao T, Fukuda H.

    Brain Behavior and Immunity   2024.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough SARS-CoV-2 infection: The VENUS Study

    Murata, F; Maeda, M; Murayama, K; Nakao, T; Fukuda, H

    BRAIN BEHAVIOR AND IMMUNITY   117   521 - 528   2024.3   ISSN:0889-1591 eISSN:1090-2139

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    Language:English   Publisher:Brain, Behavior, and Immunity  

    Background: The associations between COVID-19 vaccination and post-COVID psychiatric disorders are unclear. Furthermore, it is uncertain if these associations differ depending on the dominant SARS-CoV-2 variant at the time of infection. This retrospective cohort study aimed to clarify the associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough infection according to the different variant periods in Japan. Methods: Medical claims data, COVID-19 case-related information, and vaccination records were collected from three Japanese municipalities. The study population comprised public insurance enrollees aged ≥65 years who developed COVID-19 between June 2021 and December 2022. The study exposure was each participant's vaccination status 14 days before infection, and the outcomes were the occurrence of psychiatric disorders within three months of infection. Multivariable logistic regression analyses were performed to calculate the odds ratios (ORs) and 95 % confidence intervals (CIs) of vaccination for the occurrence of psychiatric disorders. Analyses were conducted for the Delta period (June to December 2021), Omicron BA.1/BA.2 period (January to June 2022), and Omicron BA.5 period (July to December 2022). Results: We analyzed 270 participants (vaccinated: 149) in the Delta period, 2,963 participants (vaccinated: 2,699) in the Omicron BA.1/BA.2 period, and 7,723 participants (vaccinated: 7,159) in the Omicron BA.5 period. During the Delta period, vaccinated participants had significantly lower odds for psychotic disorders (OR: 0.23, 95 % CI: 0.06–0.88, P = 0.032) than unvaccinated participants. During the Omicron BA.5 period, vaccinated participants had significantly lower odds for organic mental disorders (OR: 0.54, 95 % CI: 0.30–0.95, P = 0.033), psychotic disorders (OR: 0.31, 95 % CI: 0.19–0.53, P < 0.001), mood disorders (OR: 0.53, 95 % CI: 0.29–0.99, P = 0.046), and insomnia (OR: 0.48, 95 % CI: 0.32–0.72, P < 0.001) than unvaccinated participants. There were no significant differences in psychiatric disorders between the vaccinated and unvaccinated groups during the Omicron BA.1/BA.2 period. Conclusions: This is the first study to demonstrate that the associations between COVID-19 vaccination and post-COVID psychiatric disorders vary among the different variant periods. Future studies on these associations should be conducted with consideration to the prevalent circulating variants.

    DOI: 10.1016/j.bbi.2024.02.018

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  • Posterior cingulate cortex spontaneous activity associated with motor response inhibition in patients with obsessive-compulsive disorder: A resting-state fMRI study. Invited Reviewed International journal

    Hirofumi Tomiyama, Keitaro Murayama , Kiyotaka Nemoto , Mayumi Tomita, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Akira Matsuo 1, Aikana Ohno, Mingi Kang, Osamu Togao, Akio Hiwatashi, Kousei Ishigami, Tomohiro Nakao

    Psychiatry Research Neuroimaging.   334   111669   2023.9   ISSN:0925-4927 eISSN:1872-7506

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pscychresns.2023.111669

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  • Gyrification of the medial and lateral orbitofrontal cortex in first-degree relatives of patients with obsessive-compulsive disorder

    Tomiyama, H; Murayama, K; Nemoto, K; Kato, K; Matsuo, A; Ohno, A; Kang, M; Togao, O; Ishigami, K; Nakao, T

    CEREBRAL CORTEX   33 ( 14 )   8913 - 8920   2023.7   ISSN:1047-3211 eISSN:1460-2199

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    Language:English   Publisher:Cerebral Cortex  

    Gyrification patterns ref lect early neurodevelopment and could be highly heritable. While some discrepant results have been reported, the most consistent finding was that patients with obsessive-compulsive disorder showed altered gyrification patterns in the orbitofrontal cortex. Nevertheless, no study has investigated the alterations in gyrification in unaffected first-degree relatives of patients with obsessive-compulsive disorder. We measured local gyrification by the FreeSurfer software in 23 unaffected first-degree relatives of patients with obsessive-compulsive disorder and 52 healthy control participants. We explored differences in the local gyrification index using vertex-wise whole-brain analysis and a region of interest-based approach in the medial and lateral orbitofrontal cortex. There was no significant difference in the local gyrification index between the 2 groups in the vertex-wise whole-brain analysis. Region of interest analyses showed that, compared with healthy controls, first-degree relatives showed significantly reduced local gyrification index in the left medial and lateral orbitofrontal cortex. A negative correlation was observed between the reduced local gyrification index in lateral orbitofrontal cortex and the subclinical anxiety scores of first-degree relatives. Our results showed that first-degree relatives of patients with obsessive-compulsive disorder had an altered local gyrification index in the orbitofrontal cortex. Especially, reduced local gyrification index in lateral orbitofrontal cortex associated with subclinical anxiety symptom could be a potential neurodevelopmental marker for the illness onset.

    DOI: 10.1093/cercor/bhad170

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  • The impact of gender and age differences and infectious disease symptoms on psychological distress in quarantined asymptomatic or mildly ill COVID-19 patients in Japan. Reviewed International journal

    Keitaro Murayama, Hideharu Tatebayashi, Takako Kawaguchi, Kousuke Fujita, Kenta Sashikata and Tomohiro Nakao.

    International Journal of Environmental Research and Public Health.   2023.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijerph19159083.

  • Functional connectivity between pre-supplementary motor area and inferior parietal lobule associated with impaired motor response inhibition in first-degree relatives of patients with obsessive-compulsive disorder

    Tomiyama, H; Murayama, K; Nemoto, K; Tomita, M; Kato, K; Matsuo, A; Ohno, A; Kang, MG; Togao, O; Ishigami, K; Nakao, T

    CEREBRAL CORTEX   33 ( 12 )   7531 - 7539   2023.6   ISSN:1047-3211 eISSN:1460-2199

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    Previous studies have suggested that specific fronto-striatal circuits are associated with impaired motor response inhibition in patients with obsessive-compulsive disorder (OCD) and their relatives. However, no study has investigated the underlying resting-state network associated with motor response inhibition in the unaffected first-degree relatives of patients with OCD. We measured motor response inhibition using stop-signal task, and obtained resting-state fMRI in 23 first-degree relatives and 52 healthy control participants. We explored the group differences in the functional network from seed regions-of-interest (ROIs) associated with motor response inhibition abilities. We used the inferior frontal gyrus (IFG) and pre-supplementary motor area (pre-SMA) as seed-ROIs. A significant group difference was observed in functional connectivity between the pre-SMA and inferior parietal lobule. In the relative group, reduced functional connectivity between these areas was associated with a longer stop-signal reaction time. Additionally, relatives showed significantly greater functional connectivity between the IFG and SMA, precentral, and postcentral areas. Our results could provide new insights into the resting-state neural activity of the pre-SMA underlying impaired motor response inhibition of unaffected first-degree relatives. In addition, our results suggested that relatives have an altered connectivity of the sensorimotor region, similar to that of patients with OCD shown in previous literature.

    DOI: 10.1093/cercor/bhad058

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  • Decision-making deficits in obsessive-compulsive disorder are associated with abnormality of recency and response consistency parameter in prospect valence learning model. Invited Reviewed International journal

    Keitaro Murayama, Hirofumi Tomiyama, Aikana Ohno, Kenta Kato, Akira Matsuo, Suguru Hasuzawa, Kenta Sashikata, Mingi Kang, Tomohiro Nakao

    Frontiers in Psychiatry   14   1227057   2023.5   ISSN:1664-0640

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    DOI: 10.3389/fpsyt.2023.1227057

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  • Survey of psychiatric symptoms among inpatients with COVID-19 using the Diagnosis Procedure Combination data and medical records in Japan. Invited Reviewed International journal

    NAKAO Tomohiro, MURAYAMA Keitaro, FUKUDA Haruhisa, ETO Nobuaki, FUJITA Kousuke, IGATA Ryohei, ISHIKAWA Kensuke, ISOMURA Shuichi, KAWAGUCHI Takako, MAEDA Megumi, MITSUYASU Hiroshi, MURATA Fumiko, NAKAMURA Tomoyuki, NISHIHARA Tomoe, OHASHI Ayako, SATO Mamoru, YOSHIDA Yuj, KAWASAKI Hiroaki, OZONE Motohiro, YOSHIMURA Reij, TATEBATASHI Hideharu

    29   100615   2023.5   ISSN:2666-3546

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbih.2023.100615

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  • Gyrification of the medial and lateral orbitofrontal cortex in first-degree relatives of patients with obsessive-compulsive disorder. Invited Reviewed International journal

    Hirofumi Tomiyama, Keitaro Murayama , Kiyotaka Nemoto , Kenta Kato, Akira Matsuo , Aikana Ohno, Mingi Kang, Osamu Togao, Kousei Ishigami, Tomohiro Nakao

    Cerebral Cortex.   2023.5

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    DOI: 10.1093/cerecor/bhad170.

  • 特集 災害精神医学-自然災害,人為災害,感染症パンデミックとこころのケア 新型コロナウイルス感染による罹患後症状

    中尾 智博, 村山 桂太郎

    精神医学   65 ( 3 )   369 - 376   2023.3   ISSN:04881281 eISSN:1882126X

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1405206876

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  • Functional connectivity between pre-supplementary motor area and inferior parietal lobule associated with impaired motor response inhibition in first-degree relatives of patients with obsessive-compulsive disorder. Invited Reviewed International journal

    Hirofumi Tomiyama, Keitaro Murayama , Kiyotaka Nemoto , Mayumi Tomita , Kenta Kato, Akira Matsuo 1, Aikana Ohno, Mingi Kang, Osamu Togao, Kousei Ishigami, Tomohiro Nakao.

    Cerebral Cortex   2023.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bhad058.

  • Psychological treatments for the mental health symptoms among individuals infected with COVID-19: a scoping review protocol. Reviewed International journal

    So Sugita, Kotone Hata, Naoki Takamatsu, KentaroKimura, Lecsy Gonzalez, Krandhasi Kodaiarasu, Christian Miller, Ikue Umemoto, Keitaro Murayama, Tomohiro Nakao, Shinsuke Kito, Masaya Ito, Hironori Kuga.

    BMJ Open.   13 ( 3 )   e069386   2023.3   ISSN:2044-6055

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2022-069386

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  • ためこみ症の発症に関連する臨床因子の調査及び予防・治療介入に対する考察

    加藤 研太, 村山 桂太郎, 豊見山 泰史, 蓮澤 優, 溝部 太郎, 松尾 陽, 指方 賢太, 中尾 智博

    メンタルヘルス岡本記念財団研究助成報告集   ( 34 )   17 - 22   2023.3   ISSN:0916-9156

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    Language:Japanese   Publisher:(公財)メンタルヘルス岡本記念財団  

    2019年4月から2022年3月に九州大学病院精神科神経科を受診した、ためこみ症(Hoarding disorder:HD)患者で、研究に参加協力が可能な患者にHD発症前のライフイベントについて調査した。対象者を募り、同意を得た上で詳細な生育環境・生活環境について面接による調査を行った。さらにSocial Readjustment Rating Scale(SRRS)を用いて、ためこみ症発症前に認めたライフイベントを網羅的に調査した。対象となった患者は21名(男性6名、女性15名、平均年齢45.6±11.1歳、発症平均年齢19.9±8.38歳)、併存症はADHD 13名、気分障害12名(大うつ病性障害11名、双極性1型障害1名)などであった。発症前のライフイベントに関する調査では、分離に合致するライフイベントを認めた割合は21名中18名であった。発症前のネガティブなライフイベントとしての「児童青年期のライフイベント」と所有物への信念としての「感傷的な価値」間にのみ有意な関連が認められた。

  • Applied Tension法の施行時に生理学的指標を測定し、患者と共有したことが治療の進展に寄与したと考えられた血液・注射・外傷型の限局性恐怖症の一症例. Reviewed

    村山桂太郎

    認知行動療法研究.   2022.9

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  • Applied Tension法の施行時に生理的指標を測定し、患者と共有したことが治療の進展に寄与したと考えられた血液・注射・外傷型の限局性恐怖症の一症例

    村山 桂太郎

    認知行動療法研究   48 ( 3 )   273 - 284   2022.9   ISSN:2433-9075

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    注射恐怖症の患者に対してApplied Tension法(ApT)を施行した際、患者の生理学的指標を継時的に測定しそれを共有した事が、治療の進展に寄与したと考えられたため報告する。患者は20歳代の女性で、採血や点滴時に気分不良が生じるため、病院受診を長期間回避していた。治療は曝露法と筋緊張法を組み合わせたApTを用いた。治療者は、気分不良の原因である循環動態の変化を脈拍数と血圧値という客観的なデータとして測定した。測定は曝露前、曝露時、筋緊張法施行時と継時的に行い、ApT後にその推移を患者と共有した。12セッションを経て採血時の気分不良は生じなくなり、採血に対する患者の不安は消退した。10週間後のフォローアップセッションでも気分不良の再燃はなかった。ApTにおいて脈拍数と血圧値の推移を患者と共有することで患者自身が病態と治療の仕組みについて理解が進み、治療の進展に寄与できたと考えられた。(著者抄録)

  • The Impact of Gender and Age Differences and Infectious Disease Symptoms on Psychological Distress in Quarantined Asymptomatic or Mildly Ill COVID-19 Patients in Japan

    Murayama, K; Tatebayashi, H; Kawaguchi, T; Fujita, K; Sashikata, K; Nakao, T

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   19 ( 15 )   2022.8   ISSN:16617827 eISSN:1660-4601

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    Quarantine imposed due to COVID-19 infection can exacerbate psychological distress, and it is important for a public mental health agency to identify factors that are predictive of high psychological distress in such situation. The aim of this study was to investigate whether gender, age, and the presence or absence of infectious disease symptoms affected psychological distress among asymptomatic or mildly ill COVID-19 patients who were quarantined. Participants were 436 asymptomatic or mildly symptomatic COVID-19-infected patients who were quarantined in a treatment facility between 1 May 2020 and 30 September 2021. We used Quantification Theory I analysis to investigate the effects of gender, age, and the nature of infectious disease symptoms on psychological distress. The results of the analysis showed that the contribution rate was 0.06. Among gender, age, presence of symptoms, and the nature of symptoms, age had the greatest effect on psychological distress, and being in one’s teens to thirties was considered to exacerbate psychological distress the most. According to the results, the psychological distress of asymptomatic and mildly symptomatic COVID-19 patients isolated was affected by gender, age, and symptomology, especially due to age differences. However, the impact of these items on psychological distress was not considered significant.

    DOI: 10.3390/ijerph19159083

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  • Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder. Reviewed International journal

    Hirofumi Tomiyama, Keitaro Murayama, Kiyotaka Nemoto, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Akira Matsuo, Aikana Ohno, Mingi Kang, Osamu Togao, Akio Hiwatashi, Kousei Ishigami, Tomohiro Nakao.

    Progress in Neuro-Psychopharmacology and Biological Psychiatry   2022.6

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    DOI: 10.1016/j.pnpbp.2022.110516

  • Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects

    Hasuzawa, S; Tomiyama, H; Murayama, K; Ohno, A; Kang, MG; Mizobe, T; Kato, K; Matsuo, A; Kikuchi, K; Togao, O; Nakao, T

    FRONTIERS IN PSYCHIATRY   13   836965   2022.5   ISSN:1664-0640

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    Language:English   Publisher:Frontiers in Psychiatry  

    Background: Symptoms of obsessive-compulsive disorder (OCD) have been conceptualized as manifestations of decision-making deficits. Patients with OCD exhibit impairment during the decision-making process, as assessed by the Iowa Gambling Task (IGT). This impairment is independent of clinical severity and disease progression. However, the association between the decision-making deficit and resting-state brain activity of patients with OCD has not been examined. Methods: Fifty unmedicated patients with OCD and 55 matched control subjects completed IGT. Resting-state brain activity was examined using the fractional amplitude of low-frequency fluctuations (fALFFs). fALFF analysis focused on the slow-4 and 5 bands. Group comparisons were performed to determine the association between IGT performance and fALFFs. Results: There was a significant group difference in the association between the IGT total net score and slow-4 fALFFs in the left putamen (voxel height threshold of p < 0.001; cluster size threshold of p < 0.05; family wise error-corrected). Higher putamen slow-4 fALFFs were correlated with lower IGT scores for OCD patients (r = −0.485; p < 0.0005) and higher IGT scores for control subjects (r = 0.402; p < 0.005). There was no group difference in the association between the IGT total net score and slow-5 fALFFs. Conclusions: These findings in unmedicated patients demonstrate the importance of resting-state putamen activity for decision-making deficit associated with OCD, as measured by IGT. The inverse correlation may be explained by the hypersensitive response of the putamen in patients with OCD.

    DOI: 10.3389/fpsyt.2022.836965

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  • Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects. Reviewed International journal

    Hasuzawa S, Tomiyama H, Murayama K, Ohno A, Kang M, Mizobe T, Kato K, Matuso A, Kikuchi K, Togao O, Nakao T.

    Front Psychiatry. 2022 May 13;13:836965.   2022.5

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    DOI: 10.3389/fpsyt.2022.836965. eCollection 2022.

  • Abnormal white matter structure in hoarding disorder

    Mizobe, T; Ikari, K; Tomiyama, H; Murayama, K; Kato, K; Hasuzawa, S; Togao, O; Hiwatashi, A; Nakao, T

    JOURNAL OF PSYCHIATRIC RESEARCH   148   1 - 8   2022.4   ISSN:0022-3956 eISSN:1879-1379

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    Language:English   Publisher:Journal of Psychiatric Research  

    Although preliminary neuroimaging research suggests that patients with hoarding disorder (HD) show widespread abnormal task-related activity in the brain, there has been no research on alterations in the white matter tracts in these patients. The aim of this study was to investigate the characteristics of the major white matter tracts in patients with HD. Tract-based spatial statistics were used to search for white matter tract abnormalities throughout the brain in 25 patients with HD and 36 healthy controls. Post hoc analysis of regions of interest was performed to detect correlations with clinical features. Compared with the controls, patients with HD showed decreased fractional anisotropy and increased radial diffusivity in anatomically widespread white matter tracts. Post hoc analysis of regions of interest revealed a significant negative correlation between the severity of hoarding symptoms and fractional anisotropy in the left anterior limb of the internal capsule and a positive correlation between the severity of these symptoms and radial diffusivity in the right anterior thalamic radiation. Patients with HD showed a broad range of alterations in the frontal white matter tracts, including the frontothalamic circuit, frontoparietal network, and frontolimbic pathway. The findings of this study indicate associations between frontal white matter abnormalities related to the severity of hoarding symptoms in HD and the cortical regions involved in cognitive dysfunction. The insights provided would be useful for understanding the neurobiological basis of HD.

    DOI: 10.1016/j.jpsychires.2022.01.031

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  • Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive-compulsive disorder

    Tomiyama, H; Murayama, K; Nemoto, K; Tomita, M; Hasuzawa, S; Mizobe, T; Kato, K; Ohno, A; Tsuruta, S; Togao, O; Hiwatashi, A; Nakao, T

    HUMAN BRAIN MAPPING   43 ( 3 )   974 - 984   2022.2   ISSN:1065-9471 eISSN:1097-0193

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    Language:English   Publisher:Human Brain Mapping  

    Recent evidence suggests that presupplementary motor area (pre-SMA) and inferior frontal gyrus (IFG) play an important role in response inhibition. However, no study has investigated the relationship between these brain networks at resting-state and response inhibition in obsessive–compulsive disorder (OCD). We performed resting-state functional magnetic resonance imaging scans and then measured the response inhibition of 41 medication-free OCD patients and 49 healthy control (HC) participants by using the stop-signal task outside the scanner. We explored the differences between OCD and HC groups in the functional connectivity of pre-SMA and IFG associated with the ability of motor response inhibition. OCD patients showed a longer stop-signal reaction time (SSRT). Compared to HC, OCD patients exhibit different associations between the ability of motor response inhibition and the functional connectivity between pre-SMA and IFG, inferior parietal lobule, dorsal anterior cingulate cortex, insula, and anterior prefrontal cortex. Additional analysis to investigate the functional connectivity difference from the seed ROIs to the whole brain voxels revealed that, compared to HC, OCD exhibited greater functional connectivity between pre-SMA and IFG. Also, this functional connectivity was positively correlated with the SSRT score. These results provide additional insight into the characteristics of the resting-state functional connectivity of the regions belonging to the cortico-striato-thalamo-cortical circuit and the cingulo-opercular salience network, underlying the impaired motor response inhibition of OCD. In particular, we emphasize the importance of altered functional connectivity between pre-SMA and IFG for the pathophysiology of motor response inhibition in OCD.

    DOI: 10.1002/hbm.25699

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  • Mental health problems and countermeasures during the coronavirus disease pandemic in Japan: a nationwide questionnaire survey of mental health and psychiatric institutions. Reviewed International journal

    Tomohiro Nakao, Keitaro Murayama, Sho Takahashi, Mami Kayama, Daisuke Nishi, Toru Horinouchi, Hironori Kuga

    International Journal of Environmental Research and Public Health.   8 ( 14 )   2021.7

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    DOI: 10.3390/ikerph18147318

  • Abnormal white matter structure in hoarding disorder. Reviewed International journal

    Mizobe T, Ikari K, Tomiyama H, Murayama K, Kato K, Hasuzawa S, Togao O, Hiwatashi A, Nakao T

    Journal of Psychiatric Research. 2022 Jan 18;148:1-8.   2021.1

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    DOI: 10.1016/jpsychires.202201031.

  • 体重へのこだわりによる生活障害が著しい自閉スペクトラム症の患者に対して森田療法的アプローチにより生活の質が向上した一例 Reviewed

    村山桂太郎

    日本森田療法学会誌   2020.9

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  • A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI. Reviewed International journal

    Momosaka D, Togao O, Hiwatashi A, Yamashita K, Kikuchi K, Tomiyama H, Nakao T, Murayama K, Suzuki Y, Honda H

    PLoS One   2020.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone

  • Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder. Reviewed International journal

    Tomiyama H, Nakao T, Murayama K, Nemoto K, Ikari K, Yamada S, Kuwano M,, Hasuzawa S, Togao O, Hiwatashi A, Kanba S

    Neuroimaging Clin   2020.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nicl.2019

  • Clinical characteristics of hoarding disorder in Japanese patients. Reviewed International journal

    Kuwano M, Nakao T, Yonemoto K, Yamada S, Murayama K, Okada K, Honda S, Ikari K, Tomiyama K, Hasuzawa S, Kanba S

    Heliyon   2020.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.heliyon.2020

  • Autogenous obsessionを有する強迫症に森田療法的アプローチが有効であった一例 Reviewed

    村山桂太郎

    日本森田療法学会雑誌   2019.10

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  • The relationship between seizure in electroconvulsive therapy and pupillary response using an automated pupilometer Reviewed International journal

    Shirozu K, Murayama K, Yamaura K

    Journal of Visualized Experiments   2019.4

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    DOI: 10.3791/59488 2019

  • The relationship between seizure in electroconvulsive therapy and pupillary response using an automated pupilometer. Reviewed International journal

    Shirozu K, Murayama K, Karashima Y, Setoguchi H, Miura T, Hoka S

    Journal of Anesthesia   2018.12

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  • A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder. Reviewed International journal

    Yamada S, Nakao T, Ikari K, Kuwano M, Murayama K, Tomiyama H, Hasuzawa S, Togao O, HIwatashi A, Kanba S

    PLoS One   2018.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0200814

  • A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients Reviewed International journal

    Annals of General Psychiatry   17 ( 16 )   2017.9

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    DOI: 10.1186/s12991-017-0126-6

  • Morphologic and clinical differences between Early- and Late-onset obsessive compulsive disorder: Voxel-based Morphometric study Reviewed International journal

    Ikari K, Nakao T, Nemoto K, Okada K, Murayama K, Honda S, Kuwano M, Yamada S, Tomiyama H, Tomita M, Togao O, Hiwatashi A, Kanba S

    Journal of Obsessive-Compulsive and Related Disorders   13 ( 4 )   35 - 41   2017.4

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  • Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment Invited Reviewed International journal

    Okada K, Nakao T, Sanematsu H, Murayama K, Honda S, Tomita M, Togao O, Yoshiura T, Kanba S

    Psychiatry and Clinical Neuroscience   69 ( 7 )   411 - 421   2015.7

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  • fMRI of patients with social anxiety disorder during a social situation task. Reviewed International journal

    Nakao T, Sanematsu H, Yoshiura T, Togao O, Murayama K, Tomita M, Masuda Y, Kanba S

    Neuroscience Research   2011.1

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Books

  • 認知行動療法の考えに基づく介入法.令和4年度版新型コロナウイルス流行下におけるメンタルヘルス問題への対応マニュアル

    村山桂太郎( Role: Joint author)

    2024.5 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • 認知行動療法の考えに基づく介入法. 新型コロナウイルス流行下におけるメンタルヘルス問題への対応マニュアル.

    村山 桂太郎( Role: Joint author)

    2021.9 

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    Language:Japanese   Book type:General book, introductory book for general audience

  • その他の強迫症または関連症群. 講座精神疾患の臨床3

    村山 桂太郎( Role: Joint author)

    中山書店, 東京,  2021.2 

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    Responsible for pages:pp223-230   Language:Japanese   Book type:Scholarly book

  • 特定の恐怖症. 認知行動療法事典.

    村山 桂太郎( Role: Joint author)

    2019.9 

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    Responsible for pages:pp102-103   Language:Japanese   Book type:Scholarly book

  • 依存性パーソナリティ障害.  別冊日本臨床 精神医学症候群(第2版)-物質関連障害および嗜癖性症候群からてんかんまで−.

    村山 桂太郎( Role: Joint author)

    日本臨床社, 東京  2017.6 

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    Responsible for pages:pp287-290   Language:Japanese   Book type:Scholarly book

  • 依存性パーソナリティ障害.  DSM-5を読み解く5

    村山 桂太郎, 中尾 智博( Role: Joint author)

    中山書店, 東京,  2014.9 

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    Responsible for pages:pp211-216   Language:Japanese   Book type:Scholarly book

  • 強迫性緩慢. 現代精神医学事典(加藤敏・神庭重信・中谷陽二ら編)

    村山桂太郎( Role: Joint author)

    2011.10 

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  • 深部脳刺激[DBS]. 現代精神医学事典(加藤敏・神庭重信・中谷陽二ら編)

    村山 桂太郎( Role: Joint author)

    2011.10 

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Presentations

  • 強迫症患者と第一度親族における意思決定機能〜意思決定機能は強迫症におけるエンドフェノタイプなのか?〜

    村山桂太郎、豊見山泰史、大野愛哉、蓮澤優、溝部太郎、加藤研太、Kang Mingi、松尾陽、中尾智博

    第13回不安症学会  2021.5 

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    Event date: 2021.5 - 2022.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 成人患者に対する薬物療法の導入 Invited

    村山桂太郎

    第15回不安症学会学術大会  2023.5 

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    Event date: 2024.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Measuring Physiological Indices During Applied Tension and Sharing Them with the Patient Contributed to the Efficacy of the Treatment for Blood-Injection-Injury Phobia: A Case Report. International conference

    Keitaro Murayama

    8th Asian Cognitive Behavioral Therapy Congress.  2024.2 

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    Event date: 2024.2

    Language:Japanese  

    Country:India  

  • 不合理感が乏しく治療に難渋している強迫症の一例

    松尾陽, 村山桂太郎, 中尾智博.

    日本認知・行動療法学会第49回大会  2023.10 

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    Event date: 2023.10

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • 強迫症における反応抑制障害は罹病期間と相関を認めるか?〜Stop Signal Taskを用いた反応抑制障害の研究〜

    村山桂太郎, 豊見山泰史, 指方賢太, Kang Mingi, 加藤研太, 松尾陽, 大野愛哉,中尾智博

    日本認知・行動療法学会第49回大会.  2023.10 

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    Event date: 2023.10

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • 強迫症の認知行動療法 Invited

    村山桂太郞、豊見山泰史、加藤研太

    第22回日本認知療法・認知行動療法学術大会  2022.11 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知行動療法の技法に基づく対応とRAPID-PFA(Psychological First Aid)を取り入れた「新型コロナウイルス流行下におけるメンタルヘルス問題への対応マニュアル」の開発

    村山桂太郎, 中尾智博, 高橋晶, 萱間真美, 堀之内透, 西大輔, 久我弘典

    日本認知・行動療法学会 第48回大会  2022.10 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  • A NATIONWIDE QUESTIONNAIRE SURVEY OF MENTAL HEALTH: VIDEO CONFERENCING BY COUNSELORS WITH RAPID-PFA TRAINING DURING THE COVID-19 PANDEMIC IN JAPAN. International conference

    uji Iijima, Asami Komazawa, Ikue Umemoto, Kei Matsuura, Keitaro Murayama, Kazuyuki Nakagome, Tomohiro Nakao, Hironori Kuga.

    World Congress of Psychiatry  2022.8 

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    Event date: 2023.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • ためこみ症発症の臨床因子に関する検討:所有物への信念とライフイベント.

    加藤研太, 村山桂太郎, 豊見山泰史, 松尾陽, 中尾智博.

    日本認知・行動療法学会第48回大会.  2022.10 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  • 療養施設に隔離となった無症状および軽症COVID-19患者の心理的苦痛:感染症状の有無や性別、年代が心理的苦痛に影響を与えたか?

    村山桂太郎, 楯林英晴, 川口貴子, 藤田浩介, 指方賢太, 中尾智博

    日本精神衛生学会第38回大会.  2022.10 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:兵庫   Country:Japan  

  • 入院による認知行動療法及び薬物療法が奏功した強迫症の一例

    森口浩史, 松尾陽, 豊見山泰史, 村山桂太郎, 中尾智博.

    第74回九州精神神経学会  2022.11 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 新しいサイコロジカルファーストエイドとオンラインメンタルヘルスケアシステム「KOKOROBO」 Invited

    村山桂太郎

    第119回日本精神神経学会学術大会  2023.6 

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    Event date: 2023.6 - 2024.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • OCDの多様性〜Sensory Phenomenaの視点から〜 Invited

    村山桂太郎

    第119回日本精神神経学会学術大会  2024.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • COVID-19は感染者の精神面にどのような影響を与えたか Invited

    村山桂太郎

    第118回日本精神神経学会学術総会  2022.6 

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    Event date: 2022.6 - 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 入院治療の意義:心理教育と集中的CBT. 第14回日本不安症学会学術大会, シンポジウム「強迫症に入院治療を必要か、そして有効か」. Invited

    村山桂太郎

    第14回日本不安症学会学術大会  2022.5 

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    Event date: 2022.5 - 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • ためこみ症の安静時脳活動

    加藤研太, 豊見山泰史, 村山桂太郎, 中尾智博

    第14回日本不安症学会学術大会  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • SSRI治療抵抗性OCD患者に対する非定型抗精神病薬による増強療法 Invited

    村山桂太郎

    第14回日本不安症学会学術大会  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • OCDに対するSSRIの有効性の検討 Invited

    村山桂太郎

    第14回日本不安症学会学術大会  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • OCDと曝露露反応妨害法. Invited

    村山桂太郎

    第14回日本不安症学会学術大会  2022.5 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 森田療法の今後の100年〜森田療法に量的エビデンスは必要か〜.

    村山桂太郎

    日本森田療法学会第38回大会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web   Country:Japan  

  • 「認知行動療法の実践における共感と同盟:実践上の落とし穴や初学者のためのヒント」

    村山桂太郎

    日本認知・行動療法学会第47回大会  2021.10 

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    Event date: 2021.10 - 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web   Country:Japan  

  • 強迫症患者における感覚現象の有無による認知機能の差異

    村山桂太郎, 豊見山泰史, Kang Mingi,、蓮澤優、溝部太郎、加藤研、松尾陽、大野愛哉, 中尾智博

    日本認知・行動療法学会第47回大会  2021.10 

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    Event date: 2021.10

    Language:Japanese  

    Venue:web   Country:Japan  

  • 精神保健福祉センタースタッフによる認知行動療法の考えに基づいた心理的介入マニュアルの概要の紹介.

    村山桂太郎

    第117回日本精神神経学会学術総会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • Is there abnormal functional connectivity between the cerebellum and the cerebrum networks in un-medicated patients with obsessive-compulsive disorder? International conference

    Keitaro Murayama, Tomohiro Nakao, Hirofumi Tomiyama, Sae Tsuruta, Aikana Ohno, Suguru Hasuzawa, Shigenobu Kanba

    18th International Forum on Mood and Anxiety Disorders  2019.6 

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    Event date: 2020.6

    Language:English  

    Country:Austria  

  • こだわりによる生活障害が著しい自閉スペクトラム症に対して森田療法的アプローチにより生活の質が向上した一例.

    村山桂太郎

    第37回日本森田療法学会  2019.10 

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    Event date: 2019.10

    Language:Japanese  

    Venue:浜松   Country:Japan  

  • 先行刺激が不明瞭な強迫症に対して森田療法的アプローチが有効であった一例

    村山桂太郎

    第36回日本森田療法学会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Country:Japan  

  • グルタミン酸受容体機能調整作用を有する薬剤による強迫症治療への期待

    村山 桂太郎

    第9回日本不安症学会学術大会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:九州大学医学部百年講堂   Country:Japan  

    強迫症(Obsessive-Compulsive Disorder : OCD)の生涯有病率は1~3%といわれ、10~20歳代という小児期、青年期で発症することも多く、適切な治療を受けることが無いまま長期間経過してしまうものも少なくない。1960年代に三環系抗うつ薬であるclomipramineが本疾患の治療薬として有効であることが確認され、1990年代には選択的セロトニン取り込み阻害薬(selective serotonin reuptake inhibitor : SSRI)の有効性も確立された。現在ではSSRIによる薬物療法は各種治療ガイドラインにおいて認知行動療法とともにfirst lineの治療法として推奨されている。しかしSSRIによる治療に反応する症例は50~60%で、OCDには難治例が存在している事も事実である。この難治例に対し、近年では高用量SSRIに第二世代抗精神病薬を併用する増強療法の有効性が証明されつつあり、本疾患の病態生理はセロトニン神経系だけではなく、ドパミン機能の障害も推測されるようになった。
     さらに最近の研究により、NMDA受容体のアゴニストの一つであるグルタミン酸に関する知見やNMDA受容体機能調整薬に関する臨床研究の結果も集積してきている。そこで本発表では、これらの知見を中心に紹介し、OCDに対する新たな治療戦略の可能性を考えたい。

  • 薬物療法およびモデリングによる介入が奏功した強迫症の一例

    河村 健太郎, 加藤 研太, 豊見山 泰史, 村山 桂太郎, 中尾 智博

    九州神経精神医学  2023.8  九州精神神経学会

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  • 療養施設に隔離となった無症状および軽症COVID-19患者の心理的苦痛 感染症状の有無や性別、年代が心理的苦痛に影響を与えたか?

    村山 桂太郎, 楯林 英晴, 川口 貴子, 藤田 浩介, 指方 賢太, 中尾 智博

    こころの健康  2023.6  日本精神衛生学会

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  • 森田療法の今後の100年 森田療法に量的エビデンスは必要か

    村山 桂太郎

    日本森田療法学会雑誌  2022.10  日本森田療法学会

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  • 新規強迫症治療の現在とこれから:新たなアプローチの可能性を考える グルタミン酸系作動薬などの新規薬物療法の現在とこれから

    村山 桂太郎

    日本不安症学会/日本認知療法・認知行動療法学会合同開催プログラム・抄録集  2024.7  日本不安症学会

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  • 新型コロナウイルス感染症の罹患後症状における精神症状の病態と治療の最前線 COVID-19罹患後のメンタルヘルスの問題に対する心理社会介入の動向

    杉田 創, 畑 琴音, 高松 直岐, 木村 健太郎, Lecsy Gonzalez, Krandhasi Kodaiarasu, Christian Miller, 梅本 育恵, 村山 桂太郎, 中尾 智博, 鬼頭 伸介, 久我 弘典, 伊藤 正哉

    精神神経学雑誌  2023.6  (公社)日本精神神経学会

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  • 新型コロナウイルス感染症(COVID-19)罹患後精神症状と精神保健施設における対応 オンラインメンタルヘルスケアシステム「KOKOROBO」の概要と社会的実装にむけた課題

    村山 桂太郎

    精神神経学雑誌  2023.6  (公社)日本精神神経学会

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  • 強迫症における反応抑制障害は罹病期間と相関を認めるか? Stop Signal Taskを用いた反応抑制障害の研究

    村山 桂太郎, 豊見山 泰史, 指方 賢太, Kang Mingi, 加藤 研太, 松尾 陽, 大野 愛哉, 中尾 智博

    日本認知・行動療法学会大会プログラム・抄録集  2023.10  (一社)日本認知・行動療法学会

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  • 入院による認知行動療法及び薬物療法が奏功した強迫症の一例

    森口 浩史, 松尾 陽, 豊見山 泰史, 村山 桂太郎, 中尾 智博

    九州神経精神医学  2023.8  九州精神神経学会

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  • 不合理感が乏しく治療に難渋している強迫症の一例

    松尾 陽, 村山 桂太郎, 中尾 智博

    日本認知・行動療法学会大会プログラム・抄録集  2023.10  (一社)日本認知・行動療法学会

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  • サイコロジカル・ファーストエイドを用いたCOVID-19に起因するメンタルヘルス問題への相談システムの構築 メンタルヘルスケアシステムKOKOROBOの現状とオンライン相談の実際

    日吉 史一, 藤井 猛, 竹田 和良, 金田 匠海, 久我 弘典, 小居 秀紀, 鬼頭 伸輔, 飯島 由佳, 岩田 遼, 大庭 真梨, 村山 桂太郎, 吉見 明香, 菊地 俊暁, 中尾 智博, 渡邊 衡一郎, 中込 和幸

    精神神経学雑誌  2024.6  (公社)日本精神神経学会

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  • サイコロジカル・ファーストエイドを用いたCOVID-19に起因するメンタルヘルス問題への相談システムの構築 メンタルヘルスの問題に対応する相談員にむけたRAPID-PFA普及への取り組みとその効果

    村山 桂太郎, 久我 弘典, 大矢 希, 高橋 晶, 萱間 真美, 中尾 智博

    精神神経学雑誌  2024.6  (公社)日本精神神経学会

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  • コロナや災害から見据える今後の心理支援のあり方-誰一人取り残さない被災者支援を目指して- 災害とサイコロジカルファーストエイド・ジョンズホプキンスガイド

    村山 桂太郎

    日本不安症学会/日本認知療法・認知行動療法学会合同開催プログラム・抄録集  2024.7  日本不安症学会

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  • ためこみ症発症の臨床因子に関する検討 所有物への信念とライフイベント

    加藤 研太, 村山 桂太郎, 豊見山 泰史, 松尾 陽, 中尾 智博

    日本認知・行動療法学会大会プログラム・抄録集  2022.9  (一社)日本認知・行動療法学会

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  • ためこみ症患者における認知的柔軟性

    松隈 航, 村山 桂太郎, 豊見山 泰史, 指方 賢太, 首藤 愛佳, Kang Minji, 土岩 志保, 加藤 研太, 松尾 陽, 西田 奈美, 中尾 智博

    日本不安症学会/日本認知療法・認知行動療法学会合同開催プログラム・抄録集  2024.7  日本不安症学会

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  • ためこみ症における併存症の調査

    西田 奈美, 村山 桂太郎, 豊見山 泰史, 指方 賢太, 首藤 愛佳, 姜 ミン志, 土岩 志保, 加藤 研太, 松尾 陽, 松隈 航, 中尾 智博

    日本不安症学会/日本認知療法・認知行動療法学会合同開催プログラム・抄録集  2024.7  日本不安症学会

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MISC

  • 【精神疾患の早期発見・早期介入up to date】遠隔対応型メンタルヘルスケアシステムによる早期介入 KOKOROBO

    日吉 史一, 竹田 和良, 金田 匠海, 小居 秀紀, 飯島 由佳, 岩田 遼, 藤井 猛, 鬼頭 伸輔, 久我 弘典, 大庭 真梨, 村山 桂太郎, 中尾 智博, 中込 和幸

    臨床精神医学   53 ( 9 )   1141 - 1148   2024.9   ISSN:0300-032X

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  • 強迫

    村山桂太郎

    日本臨床 特集:メンタルヘルス 一般診療におけるメンタルヘルス問題への対応   2024.5

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  • 強迫症. よくわかる! 精神疾患対応これ一冊〜内科医と精神科医の連携のために〜

    村山桂太郎, 中尾智博

    診断と治療   2024.3

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  • 【よくわかる! 精神疾患対応 これ1冊-内科医と精神科医の連携のために】(第4部)知っておきたい精神疾患 不安症・強迫症・ストレス性疾患 強迫症

    村山 桂太郎, 中尾 智博

    診断と治療   112 ( Suppl. )   159 - 161   2024.3   ISSN:0370-999X

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    Language:Japanese   Publisher:(株)診断と治療社  

    <文献概要>1.強迫症は10~20歳代で発症し,専門医療機関に受診するまでに10年以上経過していることが多い.2.強迫症は未治療期間が長いほど,薬物療法への反応が乏しくなる.3.身体科には過剰な手洗いによる「手荒れ」で受診することがある.4.思春期~壮年期の「手荒れ」が主訴の患者は,強迫症の可能性を考え,その情報を提供することで精神科への早期受診を図ることが重要である.

  • ためこみ症の発症に関連する臨床因子の調査及び予防・治療介入に対する考察

    加藤 研太, 村山 桂太郎, 豊見山 泰史, 松尾 陽, 指方 賢太, 中尾 智博

    メンタルヘルス岡本記念財団研究助成報告集   ( 35 )   25 - 30   2024.3   ISSN:0916-9156

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  • 「不安障害に入院治療は適切か,有効か・・強迫症(OCD)の場合」 入院治療の意義 強迫症に対する心理教育の視点から

    村山 桂太郎

    日本社会精神医学会雑誌   32 ( 4 )   380 - 384   2023.11   ISSN:0919-1372

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    入院治療のメリットは,(1)患者の生活を治療者が直接観察し,認知行動療法を実施する際にどのような技法を用いて介入を行うか決定するための「患者の見立て」をより正確に行うことができること,(2)直接観察で得た情報を繰り返し面接で話題にすることで,患者が病識を得ることが進むこと,(3)強迫症状の悪化維持要因の一つである家族・支援者の「巻き込み」から患者を切り離すことができること,が挙げられる。患者の退院後の病状悪化を防ぐために,外来治療では十分な時間が確保しにくい家族・支援者に対する心理教育に時間をかけて実施できるという利点もある。その結果,強迫症状を患者と家族・支援者から切り離して外在化し,治療者を含むこれら三者が治療チームとして機能することで治療のさらなる進展が期待できる。(著者抄録)

  • 【メンタルヘルス-一般診療におけるメンタルヘルス問題への対応-】さまざまなメンタルヘルス問題とその対応 強迫

    村山 桂太郎

    日本臨床   81 ( 10 )   1524 - 1529   2023.10   ISSN:0047-1852

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  • 精神保健医療者向けの新しいサイコロジカル・ファーストエイド RAPID PFA

    村山 桂太郎

    福岡行動医学雑誌   29 ( 1 )   83 - 87   2023.9

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    深刻なストレスを及ぼす出来事に遭遇した人に対して行う心理的支援にサイコロジカル・ファーストエイド(Psychological First Aid:PFA)という支援法がある。本稿では、Johns Hopkins大学の研究者が開発したRAPID-PFAという新しいPFAの特徴を紹介した。その特徴は、これまでのPFAが、一般人も使用できるように開発されていることに対して、RAPID-PFAは、主として精神保健医療関係者が使用することを想定しており、心理的トリアージと認知再構成の技法が介入として組み込まれていることがその特徴である。今後は、RAPID-PFAをオンラインによるメンタルヘルス相談事業などに実装することで、国民のメンタルヘルスの維持向上に寄与できる可能がある。(著者抄録)

  • 新型コロナウイルス感染症による罹患後症状.

    中尾智博, 村山桂太郎

    精神医学   2023.5

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  • 入院治療の意義~強迫症に対する心理教育の視点から. Reviewed

    村山桂太郎

    日本社会精神医学会雑誌   2023.4

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  • 【災害精神医学-自然災害,人為災害,感染症パンデミックとこころのケア】新型コロナウイルス感染による罹患後症状

    中尾 智博, 村山 桂太郎

    精神医学   65 ( 3 )   369 - 376   2023.3   ISSN:0488-1281

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    <文献概要>新型コロナウイルス感染症(COVID-19)による罹患後症状は,罹患後に発生するさまざまな心身の不調である。罹患後症状には,疲労感や倦怠感,関節痛,筋肉痛,咳や息切れといったものがよくみられるが,不安やうつの出現も報告されている。海外の調査結果から,不安,抑うつといった精神症状の出現頻度はCOVID-19罹患後に高まることが示唆された。一方で長期フォローの結果は,他の呼吸器疾患と同レベルに収束することを示しており,罹患後の精神症状は,感染による心理的側面の要因が強い可能性もある。本邦では精神症状に焦点をあてた罹患後症状の大規模調査の結果はまだ報告されていないが,筆者らが行ったCOVID-19の入院患者の精神症状調査の結果からは,感染期から不安,うつ,不眠,混乱といった症状の出現頻度が増えていることが明らかになった。罹患後症状としての精神症状がウイルスの直接的な影響なのか,心理的要因が大きいかについては,今後の疫学研究や生物学的研究の蓄積が待たれる。

  • 【強迫症 レジデントが知っておきたい診断や治療のコツ!】治療・ケアの基本 強迫症の薬物療法

    村山 桂太郎

    精神科Resident   4 ( 1 )   31 - 33   2023.2   ISSN:2435-8762

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    Language:Japanese   Publisher:(株)先端医学社  

    1 強迫症(OCD)の薬物療法で第一選択薬となるのはどれか.a 抗不安薬 b 非定型抗精神病薬 c 選択的セロトニン再取込み阻害薬(SSRI)d 上記a~cのすべて e 上記a~cのいずれも第一選択薬ではない 2 OCDの薬物療法で正しい選択肢はどれか.2つ選べ.a 我が国で販売されているすべてのSSRIは,OCDに保険適応となっている.b OCDへのSSRIの治療目標用量は,うつ病と比較して高用量である.c OCDへのSSRI治療の効果判定を判断するタイミングは,患者の認容できる最大用量で最低2週間投与した直後に行う.d OCDに対するクロミプラミンの治療効果はSSRIと比較して大きい.e SSRI治療抵抗性OCDに対して非定型抗精神病薬によるSSRI付加療法が検討されることがある.(著者抄録)

  • 【病的な「とらわれ」と「こだわり」の現在形-繰り返し行動などの臨床像や対応を含めて】新型コロナウイルス感染症に関連したとらわれ・こだわり

    村山 桂太郎

    精神科治療学   38 ( 2 )   157 - 161   2023.2   ISSN:0912-1862

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    Language:Japanese   Publisher:(株)星和書店  

    2020年に始まった新型コロナウイルス感染症の世界的流行は人々の生活様式を大きく変化させた。流行初期には,ウイルスや病状に関する情報の少なさにより,人々に「不確かさへの耐性」が求められるのと同時に日常生活での行動制限も課せられ,人々の心理的苦痛が増した。そのような状況下で,一般人口では,臨床閾値下での強迫症状の増加,「食行動」や「運動」へのとらわれの増加,「強迫買い」が増加した。とらわれやこだわりがその病態と関連している強迫症や摂食障害,自閉スペクトラム症においても,それぞれ症状の増悪が報告された。新興感染症の世界的流行は,将来繰り返し発生することが考えられ,今回の知見を活かせる世界的なデータ管理と利用システムの構築が必要と考えられた。(著者抄録)

  • 新型コロナウイルス感染症に関連したとらわれ・こだわり Reviewed

    村山桂太郎

    精神科治療学   2022.2

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  • 実感と納得にむけた病気と治療の伝え方 強迫症

    村山桂太郎, 中尾智博

    精神医学   2021.11

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  • 嫌悪と強迫症

    村山桂太郎, 中尾智博

    こころの科学   2021.11

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  • ECTを臨床モデルとした生理学的研究:自律神経系での研究例

    白水和宏, 村山桂太郎, 山浦健

    臨床麻酔   2021.3

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  • 月経前不快気分障害

    村山桂太郎, 中尾智博

    精神科   2020.9

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  • 興奮性アミノ酸受容体を介した強迫症の治療メカニズム

    村山桂太郎. 中尾智博

    臨床精神薬理   2020.8

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  • 外来治療

    村山桂太郎

    公認心理師の基礎と実践22   2020.7

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  • 強迫症

    村山桂太郎

    精神科. 特別増刊号 精神科治療マニュアル. 35[suppl.1]   2020.6

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  • 症状評価尺度を再考する−強迫症−

    村山桂太郎, 中尾智博

    精神臨床薬理   2020.5

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  • 強迫症の治療における患者・家族教育

    村山桂太郎・中尾智博

    精神科. Vol.36 No.1 42-47   2020.4

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  • 精神科臨床144のQ&A

    村山桂太郎

    精神科治療学 Vol.33 増刊号   2018.11

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  • 強迫症の薬物療法における治療反応予測因子と治療戦略

    村山桂太郎、中尾智博

    臨床精神薬理   2018.2

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  • 依存性パーソナリティ障害

    村山桂太郎

    別冊日本臨床 精神医学症候群(第2版)Ⅲ   2017.9

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  • 強迫症に対するグルタミン酸神経調整薬による増強療法

    村山 桂太郎

    精神科治療学   2017.4

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  • NMDA受容体機能調整作用を有する新たな強迫症治療薬への期待

    村山 桂太郎, 中尾 智博

    臨床精神医学   2014.11

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  • 強迫性障害における脳画像研究と生物学的病態仮説

    村山 桂太郎, 中尾 智博, 神庭 重信

    福岡医学雑誌   2013.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Professional Memberships

  • 日本東洋医学会

  • 日本スポーツ精神医学会

  • 日本森田療法学会

  • 日本不安症学会

  • 日本認知・行動療法学会

  • 日本精神神経学会

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Committee Memberships

  • Executive   Domestic

    2024.4 - 2025.3   

  • 日本精神神経学会   その他   Domestic

    2015.9   

Academic Activities

  • 不明

    第3回『新型コロナウイルス流行下におけるメンタルヘルス問題への対応マニュアル』を使用するための研修会.  2022.7

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    Type:Competition, symposium, etc. 

  • 講師

    2021年度厚生労働省研修事業「強迫症の認知行動療法研修会」  2022.3

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    Type:Competition, symposium, etc. 

  • 講師

    第二回「新型コロナウイルス流行下におけるメンタルヘルス問題への対応マニュアル」を使用するための研修会  2022.2

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    Type:Competition, symposium, etc. 

    Number of participants:35

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • 講師

    第一回「新型コロナウイルス流行下におけるメンタルヘルス問題への対応マニュアル」を使用するための研修会  2021.9 - 2022.9

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    Type:Competition, symposium, etc. 

    Number of participants:22

  • シンポジスト

    日本精神神経学会学術大会, ワークショップ9-2. 不安の精神療法−日常診療でどう進めるか  2021.6

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    Type:Competition, symposium, etc. 

  • 講師

    認知・行動療法学会第46回大会ワークショップ21. 強迫症の認知行動療法  2020.9

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    Type:Competition, symposium, etc. 

  • 講師

    日本認知・行動療法学会ワークショップ:治療マニュアルを用いた強迫症の認知行動療法  ( 名古屋 ) 2019.8

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    Type:Competition, symposium, etc. 

  • 講師、ファシリテーター

    日本不安症学会主催 強迫性障害への認知行動療法研修会  ( 早稲田大学 ) 2018.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • 講師、ファシリテーター

    日本不安症学会主催 強迫性障害への認知行動療法研修会  ( 九州大学医学部同窓会会館 ) 2017.3

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  • オブザーバー International contribution

    ( 東京 ) 2016.10

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    Type:Competition, symposium, etc. 

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Research Projects

  • Abnormal cortical gyrification and executive function involvement in hoarding disorder.

    Grant number:24K10681  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • チック関連強迫性障害におけるendophenotypeの同定

    Grant number:22K07598  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    村山 桂太郎, 中尾 智博, 豊見山 泰史, 栂尾 理

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    Authorship:Principal investigator  Grant type:Scientific research funding

    強迫性障害(obsessive-compulsive disorder: OCD)の約30%はチック症を併存し、チック症関連のOCDはより遺伝的な要因の影響が強いことが知られている。
    本研究では、遺伝的な要因の関与がより大きいチック関連のOCD患者とその第一度近親者を対象とし、脳画像解析と神経心理機能検査を用いて、endophenotype(中間表現型)の調査を行い、OCDの臨床的異種性および脳画像と神経心理検査を用いた生物学的異種性を明らかにすることが目的である。

    CiNii Research

  • 新型コロナウイルス感染に起因すると考えられる精神症状に関する疫学的検討と支援策の検討に資する研究

    Grant number:22GC1005  2022 - 2024

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • Investigation of the brain structural abnormalities in Hoarding Disorder by using diffusionte

    Grant number:21K07547  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • 「精神保健医療従事者による、新型コロナウイルス感染症や自然災害等に起因した 心のケアに対する心理的アセスメント及び応急処置介入方法の適切な提供体制の構築と、それに伴うメンタルヘルスの維持向上に資する研究」

    Grant number:21GC1014  2021 - 2022

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 新型コロナウイルス感染症罹患後に精神症状が出現した者に関する実態調査

    Grant number:46  2021

    科学研究費助成事業  障害者総合福祉推進事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 精神保健医療従事者による、新型コロナウイルス感染症流行下における不安等のメンタルヘルスへの応急処置介入方法の開発と普及に資する研究

    Grant number:20CA2074  2020

    科学研究費助成事業  厚生労働科学特別研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 児童思春期強迫症における脳画像と認知機能の統合によるエンドフェノタイプの解明

    Grant number:19K08076  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    村山 桂太郎, 中尾 智博, 樋渡 昭雄, 山下 洋

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    Authorship:Principal investigator  Grant type:Scientific research funding

    強迫性障害(obsessive-compulsive disorder:OCD)の半数は児童思春期に発症する。この児童思春期発症OCDは成人期発症OCDとの臨床的異種性から、これまでの臨床研究では成人OCDと区別されて報告さてきた。
    本研究では、特に児童思春期のOCD患者とその第一度近親者(両親や同胞)を対象とし脳画像解析と神経心理機能検査を用いて、endophenotype(中間表現型)の調査を行うことで児童思春期OCDの臨床的な異種性だけではなく、脳画像と神経心理検査という客観的な指標を用いた生物学的異種性を明らかにすることが目的である。

    CiNii Research

  • 認知機能と脳画像、遺伝子の統合的解析による強迫性障害のエンドフェノタイプの解明

    Grant number:16K10253  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Working memoryと神経画像解析による強迫性障害の病態研究

    Grant number:25861017  2013 - 2015

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Class subject

  • 臨床医学Ⅴー③ 精神疾患の治療

    2024.4 - 2024.9   First semester

  • 精神疾病論「不安障害」

    2024.4 - 2024.9   First semester

  • 「パーソナリティ障害、パラフィリア、性同一性障害」

    2020.10 - 2021.3   Second semester

  • 臨床精神医学特論:強迫症と認知行動療法による治療

    2020.4 - 2020.9   First semester

  • 「パーソナリティ障害、パラフィリア、性同一性障害」

    2019.4 - 2019.9   First semester

  • 「パーソナリティ障害、パラフィリア、性同一性障害」

    2018.4 - 2018.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • 福岡県介護保険審査会委員

Social Activities

  • 「止められない〈とらわれ・こだわり〉」

    令和5年度心の健康セミナー  2024.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 災害による心理的変調とサイコロジカルファーストエイド.

    令和5年度宮崎県医師会自殺対策うつ病研修会  宮崎市  2023.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 壱岐病院における家族支援の現状と課題.

    令和2年度精神障害者家族支援強化促進事業  壱岐市  2020.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Psychiatry and Neuroscience

Clinician qualification

  • Preceptor

    The Japanese Society of Psychiatry and Neurology(JSPN)

Year of medical license acquisition

  • 2000

Notable Clinical Activities

  • 精神科外来にて行動療法専門外来を担当している。