Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia. Invited Reviewed International journal

Yamaguchi M, @Nakao S, Arita R, Kaizu Y, @Arima M, Zhou Y, Kita T, Yoshida S, Kimura K, Isobe T, Kaneko Y, @Sonoda KH, @Ishibashi T.

Invest Ophthalmol Vis Sci.   2016.4

ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function. Invited Reviewed International journal

Cui D, @Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, Matsuda S, Ikeda E.

Sci Rep.   2015.8

Involvement of periostin in regression of hyaloidvascular system during ocular development. Invited Reviewed International journal

@Arima M, Yoshida S, Nakama T, @Ishikawa K, @Nakao S, Yoshimura T, Asato R, Sassa Y, Kita T, Enaida H, Oshima Y, Matsuda A, Kudo A, @Ishibashi T.

Invest Ophthalmol Vis Sci.   2012.9

Intravitreal anti-VEGF therapy blocks inflammatory cell infiltration and re-entry into the circulation in retinal angiogenesis. Invited Reviewed International journal

@Nakao S, @Arima M, @Ishikawa K, Kohno R, Kawahara S, Miyazaki M, Yoshida S, Enaida H, Hafezi-Moghadam A, Kono T, @Ishibashi T.

Invest Ophthalmol Vis Sci.   2012.6

Microaneurysm Imaging using Multiple En Face Optical Coherence Tomography Angiography Image Averaging: Morphology and Visualization Invited Reviewed International journal

@Yoshihiro Kaizu,@Shintaro Nakao,@Iori Wada,@Mitsuru Arima,@Muneo Yamaguchi,@Keijiro Ishikawa,@Masato Akiyama,@Junji Kishimoto,@Toshio Hisatomi,@Koh-Hei Sonoda

Ophthalmology Retina.   2019.9

調節麻痺屈折検査後に閉塞隅角緑内障を発症した小児網膜疾患の2例 Reviewed

#石龍悠,@村上祐介,@有馬充,@塚本晶子,@池田康博,@園田康平

あたらしい眼科   ３６ ( 8 )   1065 - 1069   2019.8

Flow Density in Optical Coherence Tomography Angiography is Useful for Retinopathy Diagnosis in Diabetic Patients Reviewed International journal

@Yoshihiro Kaizu,@Shintaro Nakao,@Mitsuru Arima,@Takehito Hayami,@Iori Wada,@Muneo Yamaguchi,@Haruka Sekiryu,@Keijiro Ishikawa,@Yasuhiro Ikeda,@Koh-Hei Sonoda

Sci Rep.   9 ( 1 )   8668   2019.6

The utility of a new fundus camera using a portable slit lamp combined with a smartphone. Reviewed International journal

@Arima M,@Majima T,@Tsukamoto S,@Hara T,@Wada I,@Nakao S,@Sonoda KH

Acta Ophthalmol.   2019.2

Ocular findings in a case of Pierson syndrome with a novel mutation in laminin ß2 gene. Reviewed International journal

@Arima M,@Tsukamoto S,@Akiyama R,@Nishiyama K,@Kohno RI,@Tachibana T,@Hayashida A,@Murayama M,@Hisatomi T,@Nozu K,@Iijima K,@Ohga S,@Sonoda KH

J AAPOS   2018.10

Interleukin-6 plays a crucial role in the development of subretinal fibrosis in a mouse model. Reviewed International journal

@Sato K,@Takeda A,@Hasegawa E,@Jo YJ,@Arima M,@Oshima Y,@Ryoji Y,@Nakazawa T,@Yuzawa M,@Nakashizuka H,@Shimada H,@Kimura K,@Ishibashi T,@Sonoda KH

Immunol Med   2018.3

Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis. Invited Reviewed International journal

Takeda A, Yamada H, @Hasegawa E, @Arima M, @Notomi S, Myojin S, Yoshimura T, @Hisatomi T, Enaida H, Yanai R, Kimura K, @Ishibashi T, @Sonoda KH.

Jpn J Ophthalmol.   2018.3

Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy. Invited Reviewed International journal

Kaizu Y, @Nakao S, Yoshida S, Hayami T, @Arima M, Yamaguchi M, Wada I, @Hisatomi T, @Ikeda Y, @Ishibashi T, @Sonoda KH.

Invest Ophthalmol Vis Sci.   2017.9

Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV. Invited Reviewed International journal

Kobayashi Y, Yoshida S, Zhou Y, Nakama T, @Ishikawa K, Kubo Y, @Arima M, @Nakao S, @Hisatomi T, @Ikeda Y, Matsuda A, @Sonoda KH, @Ishibashi T.

Lab Invest.   2016.11

High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates. Invited Reviewed International journal

Yamaguchi M, @Nakao S, Kaizu Y, Kobayashi Y, Nakama T, @Arima M, Yoshida S, Oshima Y, Takeda A, @Ikeda Y, Mukai S, @Ishibashi T, @Sonoda KH.

Sci Rep.   2016.9

Tenascin-C promotes angiogenesis in fibrovascular membranes in eyes with proliferative diabetic retinopathy. Invited Reviewed International journal

Kobayashi Y, Yoshida S, Zhou Y, Nakama T, @Ishikawa K, @Arima M, @Nakao S, Sassa Y, Takeda A, @Hisatomi T, @Ikeda Y, Matsuda A, @Sonoda KH, @Ishibashi T.

Mol Vis.   2016.4

Antiangiogenic shift in vitreous after vitrectomy in patients with proliferative diabetic retinopathy. Invited Reviewed International journal

Yoshida S, Nakama T, @Ishikawa K, @Arima M, Tachibana T, @Nakao S, Sassa Y, Yasuda M, Enaida H, Oshima Y, Kono T, @Ishibashi T.

Invest Ophthalmol Vis Sci.   2012.10

Post-treatment change in the localization of recurrent or persistent macular edema secondary to branch retinal vein occlusion. Invited Reviewed International journal

@Arima M, Miyazaki M, Arakawa S, Mochizuki Y, @Ishibashi T.

Ophthalmologica.   2012.5

Bone marrow-derived monocyte lineage cells recruited by MIP-1β promote physiological revascularization in mouse model of oxygen-induced retinopathy. Invited Reviewed International journal

@Ishikawa K, Yoshida S, @Nakao S, Sassa Y, Asato R, Kohno R, @Arima M, Kita T, Yoshida A, Ohuchida K, @Ishibashi T.

Lab Invest.   2012.1

Increased expression of periostin in vitreous and fibrovascular membranes obtained from patients with proliferative diabetic retinopathy. Invited Reviewed International journal

Yoshida S, @Ishikawa K, Asato R, @Arima M, Sassa Y, Yoshida A, Yoshikawa H, Narukawa K, Obika S, Ono J, Ohta S, Izuhara K, Kono T, @Ishibashi T.

Invest Ophthalmol Vis Sci.   2011.7

A case of metastatic choroidal tumor simulating a choroidal melanoma. Invited Reviewed International journal

@Arima M, Yoshikawa H, Kagimoto T, @Kohno RI, @Ishibashi T.

Jpn J Ophthalmol.   2011.5

An early "reopening" case of idiopathic macular hole; supportive usefulness of fundus autofluorescence. Invited Reviewed International journal

@Arima M, Miyazaki M, @Kohno R, Hata Y, @Ishibashi T.

Graefes Arch Clin Exp Ophthalmol.   2009.5

糖尿病網膜症の網膜血管における claudin-5 発現調節機構

@有馬 充, @園田 康平

日本眼循環学会  2017.7 

網膜光凝固後の未熟児網膜症患児における1歳時の屈折値関連因子

#森雄二郎,@有馬充,@上田瑛美,@塚本晶子,@藤原康太,@秋山雅人,@園田康平

日本小児眼科学会総会  2019.6 

内頸動脈ステント留置術後に血管新生緑内障が増悪した眼虚血症候群の1例

#森賢一郎,@武田篤信,@納富昭司,@有馬充,@石川桂二郎,@園田康平

日本眼循環学会  2019.7 

加算平均OCT angiographyを用いた糖尿病網膜症における毛細血管瘤の形態解析

@福田洋輔,@中尾新太郎,@海津嘉弘,@有馬充,@和田伊織,@山口宗男,@秋山雅人,@石川桂二郎,@下川桜子,@園田康平

日本眼循環学会  2019.7 

Refractive outcomes after laser photocoagulation for retinopathy of prematurity International conference

#Yujiro Mori,@Mitsuru Arima,@Emi Ueda E,@Kohta Fujiwara,@Shoko Tsukamoto,@Masato Akiyama,@Koh-Hei Sonoda

The 12th Joint Meeting of Chinese-Japanese-Korean Ophthalmologist  2019.9 

Microaneurysm Imaging using Multiple En Face OCTA Image Averaging: Morphology and Visualization International conference

@Shintaro Nakao,@Yoshihiro Kaizu,@Iori Wada,@Mitsuru Arima,@Muneo Yamaguchi,@Keijiro Ishikawa,@Masato Akiyama,@Koh-Hei Sonoda

Retina Society Meeting  2019.9 

糖尿病網膜症における血管透過性亢進が網膜感度に及ぼす影響

@有馬充,@中尾新太郎,@海津嘉弘,@和田伊織,@山口宗男,@藤原康太,@園田康平

日本糖尿病眼学会総会  2019.9 

超高分解能OCTによるDME網膜硝子体界面所見と抗VEGF療法反応性の検討

@和田伊織,@中尾新太郎,@有馬充,@海津嘉弘,@山口宗男,@石川桂二郎,@園田康平

日本臨床眼科学会  2019.10 

OCT angiographyにおけるInterscan time変更による網膜血管検出能の検討

@海津嘉弘,@中尾新太郎,@有馬充,@和田伊織,@山口宗男,@森賢一郎,@秋山雅人,@石川桂二郎,@園田康平

日本網膜硝子体学会総会  2019.12 

AMDにおける抗VEGF療法後のCNV消退メカニズム

@和田伊織,@中尾新太郎,@海津嘉弘,@山口宗男,@森賢一郎,@石川桂二郎,@有馬充,@塩瀬聡美,@園田康平

日本眼科学会総会  2020.4 

ベバシズマブ硝子体注射を受けた未熟児網膜症患児の中枢神経発達

#森雄二郎,@有馬充,@秋山雅人,@藤原康太,@井上普介,@関瑛子,@中間崇仁,@塚本晶子,@落合正行,@大賀正一,@園田康平

日本眼科学会総会  2020.4 

ROCK inhibitor Ripasudil reverses phenotype from EMT to MET in subretinal fibrosis International conference

@Iori Wada,@Shintaro Nakao,@Muneo Yamaguchi,@Mitsuru Arima,@Ken-ichiro Mori,@Yoshihiro kaizu,@Tatsuro Ishibashi,@Koh-Hei Sonoda

Association for Research in Vision and Ophthalmology  2019.5 

The direct reprogramming of retinal astrocytes into neurons with small-molecule compounds International conference

@Yuya Fujii,@Mitsuru Arima,@Shotaro Shimokawa,@Yusuke Murakami,@Koh-Hei Sonoda

The Association for Research in Vision and Ophthalmology  2019.5 

A photographing device for ocular fundus and fluorescein angiography using a portable slit lamp International conference

@Misturu Arima,@Takuya Majima,@Shoko Tsukamoto,@Takuya Hara,@Iori Wada,@Shintaro Nakao,@Koh-Hei Sonoda

The Association for Research in Vision and Ophthalmology  2019.4 

Local Proliferation of CD206+ CX3CR1+ Macrophages at the Vitreoretinal Interface in Diabetic Retinopathy International conference

@Shintaro Nakao,@Muneo Yamaguchi,@Iori Wada,@Yoshihiro Kaizu,@Mitsuru Arima,@Keijiro Ishikawa,@Takahito Nakama,@Wataru Shiraishi,@Ryo Tamasaki,@Jun-ichi Kiram,@Tatsuro Ishibashi,@Koh-Hei Sonoda

Association of Research in Vision and Ophthalmology  2019.5 

Measurement of Vessel Tortuosity in Epiretinal Membrane in Optical Coherence Tomography Angiography International conference

@Haruka Sekiryu,@Shintaro nakao,@Hayami T,@Yoshihiro Kaizu,@Iori Wada,@Mitsuru Arima,@Keijiro Ishikawa,@Higashijima N,@Morooka K,@Koh-Hei Sonoda

Association of Research in Vision and Ophthalmology  2019.4 

Proximal but not distal retinal ischemia is associated with microaneurysms in diabetic retinopathy International conference

@Yoshihiro Kaizu,@Shintaro Nakao,@Mitsuru Arima,@Iori Wada,@Muneo Yamaguchi,@Masato Akiyama,@Keijiro Ishikawa,@Koh-Hei Sonoda

The Association for Research in Vision and Ophthalmology  2019.5 

Novel predictors of treatment-requiring retinopathy of prematurity Invited

@Mitsuru Arima

日本眼科学会総会  2019.4 

ポータブルスリットランプとスマートフォンを用いた眼底写真撮影と蛍光眼底造影

@有馬 充,@眞島 拓也,@塚本 晶子,@原 拓也,@和田 伊織,@中尾 新太郎,@園田　康平

日本眼科学会総会  2019.4 

糖尿病網膜症におけるCD206+CX3CR1+ 硝子体界面マクロファージ局所増殖

@山口　宗男,@中尾　新太郎,@和田　伊織,@海津　嘉弘,@有馬　充,@石川　桂二郎,@中間　崇仁,@白石　渉,@山崎　亮,@吉良　潤一,@石橋　達朗,@園田　康平

日本眼科学会総会  2019.4 

糖尿病網膜症における網膜血管閉塞と毛細血管瘤の空間的関連

@海津　嘉弘,@中尾　新太郎,@有馬　充,@和田　伊織,@山口　宗男,@石川　桂二郎,@秋山　雅人,@園田　康平

日本眼科学会総会  2019.4 

低分子化合物投与によるアストロサイトから網膜神経細胞へのリプログラミング

#藤井 裕也,@有馬 充,@下川 翔太郎,@村上 祐介,@園田 康平

日本再生医療学会総会  2019.3 

Novel predictors of treatment-requiring retinopathy of prematurity International conference

@Mitsuru Arima,@Shoko Tsukamoto,@Kohta Fujiwara,@Koh-Hei Sonoda

The 34th congress of asia-pacific academy of ophthalmology  2019.3 

The new development quantification system for the evaluation of disease activity in exudative age-related macular degeneration by using en face hyperreflective foci International conference

#Iori Wada,@Shintaro Nakao,@Yoshihiro Kaizu,@Muneo Yamaguchi,@Mitsuru Arima,@Keijiro Ishikawa,@Kumiko Kano,@Satomi Shiose,@Yuji Oshima,@Tatsuro Ishibashi,@Koh-Hei Sonoda

6TH INTERNATIONAL CONGRESS ON OCT ANGIOGRAPHY AND ADVANCES IN OCT  2018.12 

Microaneurysms Imaging in Diabetic Retinopathy using Multiple en face Optical Coherence Tomography Angiography Image Averaging International conference

#Yoshihiro Kaizu,@Shintaro Nakao,@Mitsuru Arima,#Iori Wada,@Keiko Yoshitomi,@Michiko Sugino,@Naoya Hashiguchi,@Kota Hirashima,@Koh-Hei Sonoda

The 11th Joint Meeting of Japan-China-Korea Ophthalmologists  2018.12 

The direct reprogramming of retinal astrocytes into neurons with small-molecule compounds International conference

#Yuya Fujii,@Mitsuru Arima,@Shotaro Shimokawa,@Yusuke Murakami,@Koh-Hei Sonoda

The 11th Joint Meeting of Japan-China-Korea Ophthalmologists  2018.12 

The evaluation of disease activity in exudative age-related macular degeneration using en face hyperreflective foci International conference

#Iori Wada,@Shintaro Nakao,@Satomi Shiose,#Yoshihiro Kaizu,@Muneo Yamaguchi,@Mitsuru Arima,@Keijiro Ishikawa,@Kumiko Kano,@Yuji Oshima,@Tatsuro Ishibashi,@Sonoda Koh-Hei

The 11th Join Meeting of Japan-China-Korea Ophthalmologists  2018.12 

Two case reports of Loeys-Dietz syndrome with retinal vascular abnormality similar to familial exudative vitreoretinopathy International conference

@Shinzo Sakisaka,@Shoko Tsukamoto,@Mitsuru Arima,@Riichiro Kono,@Shigeo Yoshida,@Koh-Hei Sonoda

The 11th Joint Meeting of Japan-China-Korea Ophthalmologists  2018.12 

家族性滲出性硝子体網膜症様所見を合併したLoeys-Dietz症候群の2例

@向坂 親蔵,@塚本 晶子,@有馬 充,@向野 利一郎,@吉田 茂生,@園田 康平

日本臨床眼科学会  2018.10 

小児網膜疾患に続発した急性閉塞隅角緑内障に対して周辺部虹彩切除術が有効であった2例

@石龍 悠,@村上 祐介,@有馬 充,@塚本 晶子,@池田 康博,@園田 康平

日本緑内障学会  2018.9 

AMDの活動性マーカーとしての En Face OCTによるhyperreflective foci

#和田 伊織,@中尾 新太郎,@大島 裕司,@海津 嘉弘,@山口 宗男,@有馬　充,@石川 桂二郎,@狩野 久美子,@塩瀬 聡美,@石橋 達朗,@園田 康平

日本眼循環学会  2018.7 

糖尿病網膜症におけるOCT angiographyの 網膜血管描出再現性は病期により異なる

#海津 嘉弘,@中尾 新太郎,@有馬 充,#和田 伊織,@石川 桂二郎,@杉野 迪子,@橋口 直哉,@吉富 景子,@平島 昂太,@園田 康平

日本眼循環学会  2018.7 

Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia

Muneo Yamaguchi, @Shintaro Nakao, Ryoichi Arita, Yoshihiro Kaizu, @Mitsuru Arima, Zhou Yedi, Takeshi Kita, Shigeo Yoshida, Kazuhiro Kimura, Isobe T, Kaneko Y, @Tatsuro Ishibashi, @Koh-Hei Sonoda

The 9th Joint Meeting of Chinese-Japanese-Korean Ophthalmologists  2016.9 

小瞳孔を伴うPierson症候群に対して瞳孔形成術を施行した症例

秋山 瑠美, @塚本 晶子, @有馬 充, 村山 美和, 向野 利一郎, 林田 陽, 園田 康平

日本小児眼科学会  2018.3 

OCTAによる網膜灌流密度は糖尿病網膜症の無灌流領域検出に有用である

石龍 悠, @中尾 新太郎, 海津 嘉弘, 吉田 茂生, @有馬 充, 和田 伊織, 山口 宗男, @石橋 達朗, @園田 康平

日本眼循環学会  2017.7 

OCTAによる網膜灌流密度の空間的パターンは糖尿病網膜症の検出に有用である

海津 嘉弘, @中尾 新太郎, 吉田 茂生, @有馬 充, 藤原 康太, 和田 伊織, 山口 宗男, @岸本 淳司, @石橋 達朗, @園田 康平

日本眼循環学会  2017.7 

中枢神経ループスに合併し，両眼性に閉塞性網膜血管症を発症したSLE網膜症の1例

武田 篤信, @石川 桂二郎, @有馬 充, @久冨 智朗, 末廣 久美子, 疋田 伸一, 森　俊輔, 仙石 昭仁, 宮村　知也, @園田 康平

2017.7 

日本血管生物医学会

ポータブルスリットランプとスマートフォンを用いた非接触式眼底カメラの開発

2018.5 - 2021.3

臨床研究助成／Rhoキナーゼ阻害剤を用いた、未熟児網膜症に対する点眼療法の開発

2018

ふくおか臨床医学研究賞／Rhoキナーゼ阻害剤を用いた、未熟児網膜症 に対する点眼療法の開発

2018

抗VEGF療法に依存しない糖尿病黄斑浮腫根治療法の開発

Grant number：17K16997  2017 - 2018

Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(A)or(B)