WAKIYAMA HIROAKI
Organization
Kyushu University Hospital Radiology Assistant Professor
Title
Assistant Professor
Profile
放射線腫瘍学および治療学全般
定位放射線治療
強度変調放射線治療
External link
Degree
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Phd
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MD
Research Interests・Research Keywords
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Research theme：Developing a novel radiosensitizer inhibiting ROS suppression by drug repositioning
Keyword：ROS radiosensitizer
Research period： 2022.4 - 2025.3
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Research theme：Development of new radiotherapy in combination with inhibitors of cancer stem cells
Keyword：radiotherapy
Research period： 2018.4 - 2018.6
Awards
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奨励賞
2018.5 癌免疫外科研究会 胃癌及び肝細胞癌におけるCytolytic activity (CYT)の臨床的意義
Papers
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Efficacy and Safety of Adjuvant Radiotherapy for Soft Tissue Sarcoma: A Two-Institution Retrospective Observational Study
Hisano O, Yoshitake T, Nomoto S, Matsumoto K, Wakiyama H,Uehara R, Takaki M, Matsumoto Y, Endo M, Nabeshima A, MatsunobuT, Maekawa A, Ishigami K
1900
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Additional radiotherapy following endoscopic submucosal dissection for T1a-MM/T1b-SM esophageal squamous cell carcinoma improves locoregional control.
Hisano O, Nonoshita T, Hirata H, Sasaki T, Watanabe H, Wakiyama H, Ono M, Ohga S, Honda H
1900
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Cytolytic Activity (CYT) Score Is a Prognostic Biomarker Reflecting Host Immune Status in Hepatocellular Carcinoma (HCC).
Wakiyama H, Masuda T, Motomura Y, Hu Q, Tobo T, Eguchi H, Sakamoto K, Hirakawa M, Honda H, Mimori K.
1900
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Real-Time Fluorescence Imaging Using Indocyanine Green to Assess Therapeutic Effects of Near-Infrared Photoimmunotherapy in Tumor Model Mice.
Rosenberg A, Fujimura D, Okada R, Furusawa A, Inagaki F, Wakiyama H, Kato T, Choyke PL, Kobayashi H.
1900
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KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma
Kitagawa A, Masuda T, Takahashi J, Tobo T, Noda M, Kuroda Y, Hu Q, Kouyama Y, Kobayashi Y, Kuramitsu S, Sato K, Fujii A, Yoshikawa Y, Wakiyama H, Shimizu D, Tsuruda Y, Eguchi H, Doki Y, Mori M, Mimori K.
1900
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Combined CD44- and CD25-Targeted Near-Infrared Photoimmunotherapy Selectively Kills Cancer and Regulatory T Cells in Syngeneic Mouse Cancer Models.
Maruoka Y, Furusawa A, Okada R, Inagaki F, Fujimura D, Wakiyama H, Kato T, Nagaya T, Choyke PL, Kobayashi H.
1900
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Wound healing after excision of subcutaneous tumors treated with near-infrared photoimmunotherapy
Rosenberg A, Inagaki F, Kato T, Okada R, Wakiyama H, Furusawa A, Choyke PL, Kobayashi H.
1900
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Interleukin-15 after Near-Infrared Photoimmunotherapy (NIR-PIT) Enhances T Cell Response against Syngeneic Mouse Tumors.
Maruoka Y, Furusawa A, Okada R, Inagaki F, Wakiyama H, Kato T, Nagaya T, Choyke PL, Kobayashi H.
1900
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Near-Infrared Photoimmunotherapy Combined with CTLA4 Checkpoint Blockade in Syngeneic Mouse Cancer Models.
Maruoka Y, Furusawa A, Okada R, Inagaki F, Fujimura D, Wakiyama H, Kato T, Nagaya T, Choyke PL, Kobayashi H.
1900
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Increased Immunogenicity of a Minimally Immunogenic Tumor after Cancer-Targeting Near Infrared Photoimmunotherapy
Wakiyama H, Furusawa A, Okada R, Inagaki F, Kato T, Maruoka Y, Choyke PL, Kobayashi H.
1900
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Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity
Okada R, Kato T, Furusawa A, Inagaki F, Wakiyama H, Choyke PL, Kobayashi H.
1900
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Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer
Hu Q, Nonaka K, Wakiyama H, Miyashita Y, Fujimoto Y, Jogo T, Hokonohara K, Nakanishi R, Hisamatsu Y, Ando K, Kimura Y, Masuda T, Oki E, Mimori K, Oda Y, Mori M.
1900
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Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials
Okada R, Furusawa A, Vermeer DW, Inagaki F, Wakiyama H, Kato T, Nagaya T, Choyke PL, Spanos WC, Allen CT, Kobayashi H
1900
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The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer
Fujii A, Masuda T, Iwata M, Tobo T, Wakiyama H, Koike K, Kosai K, Nakano T, Kuramitsu S, Kitagawa A, Sato K, Kouyama Y, Shimizu D, Matsumoto Y, Utsunomiya T, Ohtsuka T, Yamanishi Y, Nakamura M, Mimori K.
1900
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Diagnostic imaging in near-infrared photoimmunotherapy using a commercially available camera for indocyanine green
Inagaki FF, Fujimura D, Furusawa A, Okada R, Wakiyama H, Kato T, Choyke PL, Kobayashi H.
1900
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Fluorescence Imaging of Tumor-Accumulating Antibody-IR700 Conjugates Prior to Near-Infrared Photoimmunotherapy (NIR-PIT) Using a Commercially Available Camera Designed for Indocyanine Green.
Inagaki FF, Fujimura D, Furusawa A, Okada R, Wakiyama H, Kato T, Choyke PL, Kobayashi H.
1900
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Endoscopic near-infrared photoimmunotherapy in an orthotopic head and neck cancer model
Okada R, Furusawa A, Inagaki F, Wakiyama H, Kato T, Okuyama S, Furumoto H, Fukushima H, Choyke PL, Kobayashi H.
1900
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CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model
Furusawa A, Okada R, Inagaki F, Wakiyama H, Kato T, Furumoto H, Fukushima H, Okuyama S, Choyke PL, Kobayashi H.
1900
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Selection of antibody and light exposure regimens alters therapeutic effects of EGFR-targeted near-infrared photoimmunotherapy.
Okada R, Kato T, Furusawa A, Inagaki F, Wakiyama H, Fujimura D, Okuyama S, Furumoto H, Fukushima H, Choyke PL, Kobayashi H.
1900
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GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein
Koike K, Masuda T, Sato K, Fujii A, Wakiyama H, Tobo T, Takahashi J, Motomura Y, Nakano T, Saito H, Matsumoto Y, Otsu H, Takeishi K, Yonemura Y, Mimori K, Nakagawa T.
1900
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Opening up new VISTAs: V-domain immunoglobulin suppressor of T cell activation (VISTA) targeted near-infrared photoimmunotherapy (NIR-PIT) for enhancing host immunity against cancers
Wakiyama H, Furusawa A, Okada R, Inagaki F, Kato T, Furumoto H, Fukushima H, Okuyama S, Choyke PL, Kobayashi H.
1900
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Simultaneously Combined Cancer Cell- and CTLA4-Targeted NIR-PIT Causes a Synergistic Treatment Effect in Syngeneic Mouse Models.
Kato T, Okada R, Furusawa A, Inagaki F, Wakiyama H, Furumoto H, Okuyama S, Fukushima H, Choyke PL, Kobayashi H.
1900
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Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy.
Kato T, Okada R, Goto Y, Furusawa A, Inagaki F, Wakiyama H, Furumoto H, Daar D, Turkbey B, Choyke PL, Takakura H, Inanami O, Ogawa M, Kobayashi H.
1900
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Near-infrared photoimmunotherapy induced tumor cell death enhances tumor dendritic cell migration.
Moriya T, Hashimoto M, Matsushita H, Masuyama S, Yoshida R, Okada R, Furusawa A, Fujimura D, Wakiyama H, Kato T, Choyke PL, Kusumoto Y, Chtanova T, Kobayashi H, Tomura M.
1900
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Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer.
Fukushima H, Kato T, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S, Kondo E, Choyke PL, Kobayashi H.
1900
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Comparison of the Effectiveness of IgG Antibody versus F(ab')2 Antibody Fragment in CTLA4-Targeted Near-Infrared Photoimmunotherapy.
Kato T, Okada R, Furusawa A, Wakiyama H, Furumoto H, Fukushima H, Okuyama S, Choyke PL, Kobayashi H.
1900
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Selection of antibody and light exposure regimens alters therapeutic effects of EGFR-targeted near-infrared photoimmunotherapy
Okada R, Kato T, Furusawa A, Inagaki F, Wakiyama H, Fujimura D, Okuyama S, Furumoto H, Fukushima H, Choyke PL, Kobayashi H.
1900
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Optimal Light Dose for hEGFR-Targeted Near-Infrared Photoimmunotherapy
Furumoto H, Okada R, Kato T, Wakiyama H, Inagaki F, Fukushima H, Okuyama S, Furusawa A, Choyke PL, Kobayashi H.
1900
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Disialoganglioside GD2-Targeted Near-Infrared Photoimmunotherapy (NIR-PIT) in Tumors of Neuroectodermal Origin
Inagaki FF, Kato T, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S, Choyke PL, Kobayashi H.
1900
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Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy
Wakiyama H, Kato T, Furusawa A, Okada R, Inagaki F, Furumoto H, Fukushima H, Okuyama S, Choyke PL, Kobayashi H.
1900
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Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune response
Kato T, Fukushima H, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S, Takao S, Choyke PL, Kobayashi H.
1900
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Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy
Fukushima H, Furusawa A, Kato T, Wakiyama H, Takao S, Okuyama S, Choyke PL, Kobayashi H
1900
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Near-infrared photoimmunotherapy (NIR-PIT) of bone metastases
Inagaki FF, Wakiyama H, Furusawa A, Okada R, Kato T, Fujimura D, Okuyama S, Fukushima H, Takao S, Choyke PL, Kobayashi H.
1900
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Simultaneous multicolor imaging of lymph node chains using hydroporphyrin-doped near-infrared-emitting polymer dots.
Kato T, Riahin C, Furusawa A, Fukushima H, Wakiyama H, Okuyama S, Takao S, Choyke PL, Ptaszek M, Rosenzweig Z, Kobayashi H.
1900
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Near-Infrared Photoimmunotherapy Targeting Podoplanin-Expressing Cancer Cells and Cancer-Associated Fibroblasts
Kato T, Furusawa A, Okada R, Inagaki F, Wakiyama H, Furumoto H, Fukushima H, Okuyama S, Choyke PL, Kobayashi H.
1900
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Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
Kitagawa A, Osawa T, Noda M, Kobayashi Y, Aki S, Nakano Y, Saito T, Shimizu D, Komatsu H, Sugaya M, Takahashi J, Kosai K, Takao S, Motomura Y, Sato K, Hu Q, Fujii A, Wakiyama H, Tobo T, Uchida H, Sugimachi K, Shibata K, Utsunomiya T, Kobayashi S, Ishii H, Hasegawa T, Masuda T, Matsui Y, Niida A, Soga T, Suzuki Y, Miyano S, Aburatani H, Doki Y, Eguchi H, Mori M, Nakayama KI, Shimamura T, Shibata T, Mimori K.
1900
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Transvaginal approach combined intracavitary and interstitial brachytherapy assisted by transrectal ultrasound: results from 30 patients with locally advanced cervical cancer
Nakashima T, Matsumoto K, Yoshitake T, Wakiyama H, Hisano O, Uehara R, Takaki M, Oshima T, Yahata H, Ishigami K.
1900
Presentations
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Loss of fructose-1,6-bisphosphatase expression induces altering glucose metabolism and tumor progression in hepatocellular carcinoma International conference
Hiroaki Wakiyama, Hidenari Hirata, Keishi Sugimachi, Takaaki Masuda, Naoki Hayashi, Yohsuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Kotaro Terashima, Katsumi Sakamoto, Masakazu Hirakawa, Hiroshi Honda, Koshi Mimori
AACR Annual Meeting 2017 2017.4
Professional Memberships
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Japan Radiological Society
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Japanese Society for Radiation Oncology
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Japan Society of Clinical Oncology
Academic Activities
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Screening of academic papers
Role(s)： Peer review
2023
Research Projects
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食道扁平上皮癌の放射線抵抗性の原因として癌幹細胞がある。放射線による抗腫瘍効果は活性酸素(Reactive oxygen species: ROS)産生によるものが主であるが、癌幹細胞はROSを抑制することで放射線抵抗性を示す。これまで、申請者は食道扁平上皮癌細胞株に対して、ROSを抑制する薬剤のスルファサラジン投与下に放射線を照射することで、相乗効果が出現することを明らかにした。本研究ではスルファサラジンに代わる新たな放射線増感剤を、既存薬剤中より化学構造の類似性や、遺伝子発現プロファイルを用いて探索し、ドラッグリポジショニングを行うことで安全かつ相乗効果の高い放射線増感剤の同定を行う。
Grant number：19K17172 2022 - 2024
日本学術振興会 科学研究費助成事業 若手研究
Authorship：Principal investigator Grant type：Scientific research funding
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癌幹細胞選択的阻害剤とのシナジー効果による食道癌の新規放射線治療法の開発
2017 - 2018
科学研究費助成事業 若手研究(A,B)
Grant type：Scientific research funding
Media Coverage
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大分合同新聞社の朝刊において、「からだを読み解く」という医療に関したコーナーで、放射線治療についての読者向けの紹介記事を書かせていただきました。 Newspaper, magazine
大分合同新聞社 2018.7
Travel Abroad
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2019.4 - 2022.3
Staying countory name 1：United States Staying institution name 1：米国立衛生研究所（NIH）
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Radiology
Clinician qualification
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Specialist
Japanese Society for Radiation Oncology（JASTRO）
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Specialist
Japan Radiological Society（JRS）
Year of medical license acquisition
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2009