Updated on 2024/10/01

Information

 

写真a

 
KIKUCHI KAZUFUMI
 
Organization
Kyushu University Hospital Radiology Assistant Professor
Kyushu University Hospital Radiology(Joint Appointment)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425695
Profile
(研究) 1. Chemical Exchange Saturation Transfer (CEST)を含むmultiparameterによるMRIを用いた小児脳腫瘍の定量的診断法の確立 2. Intravoxel incoherent motion (IVIM) imagingの小児脳腫瘍の拡散および灌流画像として有用性の検討 3. FDG-PET/MRを用いたてんかん焦点検出の有用性の検討 4. Synthetic MRIを用いたgliomaの診断法の確立 (教育) <医学部生> 医用画像の基礎と実際を質疑形式にて説明する。CT, MRI, Angiographyの基本原理、装置の特徴、医療現場で用いられている代表的な撮像法などを説明する。 神経領域のCT, MRI, Angiographyの読影と指導; 代表的な疾患について、ティーチングファイルを用いた読影実習を通じて、基本的な画像読影法を教育する。詳細な読影所見の拾い上げとその解釈、鑑別診断、最終診断、治療法について説明する。 クリニカルクラークシップにおいては、約40例の中枢神経疾患を実際に読影させ、レポート作成実習を行う。その添削・解説を通じて、実地医療現場での読影法について指導する。 <研修医> 実際の患者のCT, MRI, Angiographyを読影させ、それを添削、指導することで読影についての基本から実際までを指導する。 Angiographyにおいては、基本手技、読影について指導する。 <大学院生> 研究のプランニング、デザイン、画像解析、統計解析、学会発表、論文作成について指導する。 各種画像診断法の読影に関する専門的知識の指導を行う。 脳血管造影や経皮的椎体形成術の実地での指導を行う。 (臨床) 九州大学病院においては放射線診断専門医として、中枢神経疾患の画像診断を専門的に携わる。 中央診療として、各科からの検査依頼の計画、実施と読影について携わる。 放射線科病棟においては、脳血管造影、経皮的生検術、経皮的椎体形成術などの患者の診療を行う。

Research Areas

  • Life Science / Radiological sciences

Research Interests・Research Keywords

  • Research theme:1. Diagnostic utility of synthetic MRI for glioma 2. Diagnostic utility of synthetic MRI for Moyamoya disease 3. Brain metastasis detection using AI

    Keyword:Chemical Exchange Saturation Transfer (CEST), Intravoxel incoherent motion (IVIM) imaging, FDG-PET/MR, Synthetic MRI

    Research period: 2018.4 - 2025.3

Awards

  • 第83回 日本医学放射線学会 総会 CyPos賞 Silver Medal

    2024.4   日本医学放射線学会   AI-VISIBLEを用いた脳転移診断の有用性

     More details

  • CyPos Award Bronze Medal

    2023.5   Japan Radiological Society  

     More details

  • The 35th Excellent Paper Award

    2023.4   Quantitative relaxometry using synthetic MRI could be better than T2‐FLAIR mismatch sign for differentiation of IDH‐mutant gliomas: a pilot study

     More details

  • Joint Annual Meeting ISMRM-ESMRMB 2018/06/16-06/21 Paris, France, Stipend受賞

    2018.6   Joint Annual Meeting ISMRM-ESMRMB 2018/06/16-06/21 Paris, France, Stipend

Papers

  • Improvement of image quality for bright-blood image in VISIBLE (volume isotropic simultaneous interleaved bright- and black-blood examination) by using k-space reordering and startup echoes. International journal

    Tatsuhiro Wada, Kazufumi Kikuchi, Makoto Obara, Chiaki Tokunaga, Koji Yamashita, Koji Kobayashi, Toyoyuki Kato, Kousei Ishigami, Osamu Togao

    Magnetic resonance imaging   112   144 - 150   2024.10   ISSN:0730-725X eISSN:1873-5894

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: A volume isotropic simultaneous interleaved bright- and black-blood examination (VISIBLE) can simultaneously acquire images with suppressed vascular signals (black-blood images) and images without suppression (bright-blood images). We aimed to improve of the bright-blood images by adjusting the k-space filling and using startup echo. METHODS: The k-space arrangement of bright-blood images in the conventional VISIBLE followed a low-to-high frequency order, whereas that in the proposed VISIBLE sequence was in the reversed order, and a startup echo was added. The effects of startup echo on the signal-to-noise ratio (SNR) were evaluated using phantoms, considering both white matter (WM) and post-contrast blood. Data from copper sulfate phantoms were acquired in 1D Fourier transform mode using both the conventional and proposed methods of the two VISIBLE sequences. The signal behavior with each sequence was evaluated. Fourteen patients with a total of 21 metastases were included in the study. For each patient, VISIBLE images of both conventional and proposed methods were obtained consecutively after the contrast agent administration. Using clinical images, we conducted a comparison of the SNR and contrast-to-noise ratio (CNR) for tumors, normal WM, and blood vessels between the conventional and proposed VISIBLE sequences. RESULTS: There was no significant difference in SNRs for both black- and bright-blood images between the conventional sequence and the proposed sequence with different number of startup echoes, however, the SNR of the proposed sequence decreased with increasing number of startup echoes in both black- and bright-images. The signal behavior of the bright-blood image reached a "steady state" when the startup echo exceeded 20. The SNRs of blood vessels in the bright-blood images did not differ significantly between conventional and proposed VISIBLE sequences. The SNRs of WM in the bright-blood images was significantly larger in the conventional sequence than in the proposed sequence. The SNRs of tumors in bright blood images was significantly larger in the proposed sequence than in the conventional sequence. The CNRs between tumors and WM, vessels and WM in the bright-blood images were significantly higher in the proposed sequence than in the conventional sequence. CONCLUSION: The use of the startup echo in combination with the high-to-low frequency k-space ordering method resulted in improved CNR of the bright-blood images in the VISIBLE sequence.

    DOI: 10.1016/j.mri.2024.07.011

    Web of Science

    Scopus

    PubMed

    researchmap

  • Artificial intelligence-assisted volume isotropic simultaneous interleaved bright- and black-blood examination for brain metastases. International journal

    Kazufumi Kikuchi, Osamu Togao, Yoshitomo Kikuchi, Koji Yamashita, Daichi Momosaka, Kazunori Fukasawa, Shunsuke Nishimura, Hiroyuki Toyoda, Makoto Obara, Akio Hiwatashi, Kousei Ishigami

    Neuroradiology   2024.8   ISSN:0028-3940 eISSN:1432-1920

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: To verify the effectiveness of artificial intelligence-assisted volume isotropic simultaneous interleaved bright-/black-blood examination (AI-VISIBLE) for detecting brain metastases. METHODS: This retrospective study was approved by our institutional review board and the requirement for written informed consent was waived. Forty patients were included: 20 patients with and without brain metastases each. Seven independent observers (three radiology residents and four neuroradiologists) participated in two reading sessions: in the first, brain metastases were detected using VISIBLE only; in the second, the results of the first session were comprehensively evaluated by adding AI-VISIBLE information. Sensitivity, diagnostic performance, and false positives/case were evaluated. Diagnostic performance was assessed using a figure-of-merit (FOM). Sensitivity and false positives/case were evaluated using McNemar and paired t-tests, respectively. RESULTS: The McNemar test revealed a significant difference between VISIBLE with/without AI information (P < 0.0001). Significantly higher sensitivity (94.9 ± 1.7% vs. 88.3 ± 5.1%, P = 0.0028) and FOM (0.983 ± 0.009 vs. 0.972 ± 0.013, P = 0.0063) were achieved using VISIBLE with AI information vs. without. No significant difference was observed in false positives/case with and without AI information (0.23 ± 0.19 vs. 0.18 ± 0.15, P = 0.250). AI-assisted results of radiology residents became comparable to results of neuroradiologists (sensitivity, FOM: 85.9 ± 3.4% vs. 90.0 ± 5.9%, 0.969 ± 0.016 vs. 0.974 ± 0.012 without AI information; 94.8 ± 1.3% vs. 95.0 ± 2.1%, 0.977 ± 0.010 vs. 0.988 ± 0.005 with AI information, respectively). CONCLUSION: AI-VISIBLE improved the sensitivity and performance for diagnosing brain metastases.

    DOI: 10.1007/s00234-024-03454-4

    Web of Science

    Scopus

    PubMed

    researchmap

  • Performance Evaluation of Commonly Used Portable Hemoglobin Sensors in Comparison to Clinical Test Results.

    Islam R, To S, Izukura R, Sato Y, Nishikitani M, Kikuchi K, Yokota F, Ikeda S, Jahan N, Ahmed A, Miyazaki M, Nakashima N

    Studies in health technology and informatics   316   416 - 417   2024.8   ISSN:0926-9630

     More details

    Language:English  

    DOI: 10.3233/SHTI240436

    PubMed

  • Hybrid Multi-Delay PCASL of Time-Encoded and Variable-TR Schemes for the Assessment of Cerebral Perfusion in Moyamoya Disease [Presidential Award Proceedings]

    TOGAO Osamu, OBARA Makoto, YAMASHITA Koji, KIKUCHI Kazufumi, WADA Tatsuhiro, TOKUNAGA Chiaki, MIKAYAMA Ryoji, ISHIDA Shota, VAN CAUTEREN Marc, ISHIGAMI Kousei

    Japanese Journal of Magnetic Resonance in Medicine   44 ( 3 )   93 - 100   2024.8   ISSN:09149457 eISSN:24340499

     More details

    Language:English   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    <p> Multi-delay PCASL acquisition with a hybrid scheme that combines time-encoded and variable-TR schemes was developed. This hybrid scheme combines the advantages of a high signal-to-noise ratio (SNR) obtained using a time-encoded scheme with the timing flexibility of a variable-TR scheme. This study aimed to investigate the ability of a hybrid scheme for cerebral blood flow (CBF) and arterial transit time (ATT) quantification in patients with Moyamoya disease. A total of 13 patients with Moyamoya disease were included in the present study. The MRI protocol included a variable TR scheme with 12 delays (vTR12), a time-encoded scheme with seven delays (TEnc7), and a hybrid scheme with 4×3 delays (Hyb12). The temporal SNR (tSNR), CBF, and ATT were measured using a vascular atlas template. The tSNR of Hyb12 was significantly higher than those of vTR12 (P<0.0001) and TEnc7 (P<0.0001). The CBF of Hyb12 was significantly lower than that of vTR12 (P=0.0186) and TEnc7 (P=0.0005). The ATT of Hyb12 was significantly shorter than those of vTR12 (P<0.0001) and TEnc7 (P<0.0001). CBF measured with Hyb12 showed significant correlations and excellent agreement with those measured with vTR12 (r=0.8269, ICC=0.8966) and TEnc7 (r=0.8586, ICC=0.9585). The quantitative capability of CBF and ATT in the hybrid scheme was confirmed in the assessment of cerebral perfusion in Moyamoya disease.</p>

    DOI: 10.2463/jjmrm.2024-1813

    CiNii Research

  • Infants' early recovery from sleep disturbance is associated with a lower risk of developmental delay in the Japan Environment and Children's Study

    Kikuchi, K; Michikawa, T; Morokuma, S; Hamada, N; Ikeda, S; Shimada, Y; Kato, K; Ochiai, M; Tsuji, M; Shimono, M; Yoshino, K; Suga, R; Kawamoto, T; Ohga, S; Kamijima, M; Yamazaki, S; Ohya, Y; Kishi, R; Yaegashi, N; Hashimoto, K; Mori, C; Ito, S; Yamagata, Z; Inadera, H; Nakayama, T; Sobue, T; Shima, M; Kageyama, S; Suganuma, N; Katoh, T

    SCIENTIFIC REPORTS   14 ( 1 )   17773   2024.8   ISSN:2045-2322

     More details

  • Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder. International journal

    Kenta Kato, Hirofumi Tomiyama, Keitaro Murayama, Taro Mizobe, Akira Matsuo, Nami Nishida, Kou Matukuma, Mingi Kang, Kenta Sashikata, Kazufumi Kikuchi, Osamu Togao, Tomohiro Nakao

    Frontiers in psychiatry   15   1399062 - 1399062   2024.6   ISSN:1664-0640

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear. METHODS: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels. RESULTS: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms. CONCLUSIONS: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.

    DOI: 10.3389/fpsyt.2024.1399062

    Web of Science

    Scopus

    PubMed

    researchmap

  • Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation

    Kamikawa, T; Hashimoto, A; Yamazaki, N; Adachi, J; Matsushima, A; Kikuchi, K; Hori, Y

    CHEMICAL SCIENCE   15 ( 21 )   8097 - 8105   2024.5   ISSN:2041-6520 eISSN:2041-6539

     More details

  • Focal 18F-fluorodeoxyglucose uptake in spinal dural arteriovenous fistula: A report of two cases(タイトル和訳中)

    Hayashida Hitoshi, Masaki Katsuhisa, Ogata Hidenori, Yamaguchi Takahiro, Tanaka Koji, Arimura Koichi, Maruoka Yasuhiro, Kikuchi Kazufumi, Togao Osamu, Yamasaki Ryo, Isobe Noriko

    Neurology and Clinical Neuroscience   12 ( 3 )   201 - 204   2024.5

     More details

    Language:English   Publisher:(一社)日本神経学会  

  • Focal <sup>18</sup>F‐fluorodeoxyglucose uptake in spinal dural arteriovenous fistula: A report of two cases

    Hitoshi Hayashida, Katsuhisa Masaki, Hidenori Ogata, Takahiro Yamaguchi, Koji Tanaka, Koichi Arimura, Yasuhiro Maruoka, Kazufumi Kikuchi, Osamu Togao, Ryo Yamasaki, Noriko Isobe

    Neurology and Clinical Neuroscience   12 ( 3 )   201 - 204   2024.5   ISSN:2049-4173 eISSN:2049-4173

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Magnetic resonance imaging of spinal dural arteriovenous fistula (SDAVF) shows longitudinally extensive spinal cord lesions mimicking neoplastic or inflammatory myelopathy. On positron emission tomography/computed tomography (PET/CT), we report two patients who showed focal <sup>18</sup>F‐fluorodeoxyglucose (FDG) uptake in longitudinally extensive spinal cord lesions. These lesions were indistinguishable from tumors or myelitis but were finally diagnosed as SDAVF. Although PET/CT availability may be limited, in cases of myelopathy with diagnostic challenges, it is important to recognize that focal FDG uptake can be observed in SDAVF.

    DOI: 10.1111/ncn3.12794

    Web of Science

    Scopus

    researchmap

  • Advantages of 3D High-Resolution Vessel Wall Imaging in a Patient With Blood Blister-Like Aneurysm: A Case Report and Literature Review. International journal

    Toru Otsuka, Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Soh Takagishi, Koichi Arimura, Akira Nakamizo, Kousei Ishigami

    Cureus   16 ( 4 )   e58376   2024.4   ISSN:2168-8184 eISSN:2168-8184

     More details

    Language:English  

    Blood blister-like aneurysms (BBAs) are rare and challenging intracranial aneurysms. They pose significant diagnostic and surgical risks due to their delicate walls. Accounting for a small percentage of intracranial aneurysms, BBAs are pathologically pseudoaneurysms, often resulting from arterial dissection, with a high tendency to rupture. This report underscores the critical nature of BBAs by reviewing a case in which subarachnoid hemorrhage caused by a BBA rupture was difficult to diagnose with conventional imaging. We highlight the efficacy of three-dimensional (3D) high-resolution vessel wall imaging (VWI) in discerning the subtle vascular abnormality of BBAs. The integration of the black-blood imaging technique within VWI provides superior contrast between the aneurysm and surrounding tissues, facilitating clearer visualization of the aneurysmal wall. The use of 3D T1-weighted imaging provides intricate details of the vessel wall including its contrast enhancement, which is crucial for a comprehensive assessment of a ruptured aneurysm. This case is consistent with the existing literature, supporting the role of VWI in the identification of ruptured BBAs, an area with limited but growing information on its diagnostic value. VWI is precise and accurate in the preoperative diagnosis of BBAs, emphasizing its potential to improve patient management and outcomes, especially in conditions with high risks of morbidity and mortality.

    DOI: 10.7759/cureus.58376

    Web of Science

    PubMed

    researchmap

  • Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function. International journal

    Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Takuro Isoda, Ataru Nishimura, Koichi Arimura, Akira Nakamizo, Koji Yoshimoto, Kousei Ishigami

    Scientific reports   14 ( 1 )   5468 - 5468   2024.3   ISSN:2045-2322

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Moyamoya disease (MMD) is characterized by progressive arterial occlusion, causing chronic hemodynamic impairment, which can reduce brain volume. A novel quantitative technique, synthetic magnetic resonance imaging (SyMRI), can evaluate brain volume. This study aimed to investigate whether brain volume measured with SyMRI correlated with cerebral blood flow (CBF) and brain function in adult MMD. In this retrospective study, 18 adult patients with MMD were included. CBF was measured using iodine-123-N-isopropyl-p-iodoamphetamine single photon emission computed tomography. Cerebrovascular reactivity (CVR) to acetazolamide challenge was also evaluated. Brain function was measured using the Wechsler Adult Intelligence Scales (WAIS)-III/IV and the WAIS-R tests. Gray matter (GM), white matter, and myelin-correlated volumes were evaluated in six areas. Resting CBF was positively correlated with GM fractions in the right anterior cerebral arterial and right middle cerebral arterial (MCA) territories. CVR was positively correlated with GM fraction in the right posterior cerebral arterial (PCA) territory. Full-Scale Intelligence Quotient and Verbal Comprehension Index scores were marginally positively correlated with GM fractions in the left PCA territory. Processing Speed Index score was marginally positively correlated with GM fraction in the right MCA territory. The SyMRI-measured territorial GM fraction correlated with CBF and brain function in patients with MMD.

    DOI: 10.1038/s41598-024-56210-2

    Web of Science

    Scopus

    PubMed

    researchmap

  • Recent advancements of fluorescent biosensors using semisynthetic probes

    Reja, SI; Minoshima, M; Hori, Y; Kikuchi, K

    BIOSENSORS & BIOELECTRONICS   247   115862   2024.3   ISSN:0956-5663 eISSN:1873-4235

     More details

  • Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted. International journal

    Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Yoshitomo Kikuchi, Daisuke Kuga, Sangatsuda Yuhei, Yutaka Fujioka, Fumiya Narutomi, Makoto Obara, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology   66 ( 3 )   333 - 341   2024.3   ISSN:0028-3940 eISSN:1432-1920

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: This study aimed to compare assessments by radiologists, artificial intelligence (AI), and quantitative measurement using synthetic MRI (SyMRI) for differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, and IDH-mutant and 1p/19q-codeleted and to identify the superior method. METHODS: Thirty-three cases (men, 14; women, 19) comprising 19 astrocytomas and 14 oligodendrogliomas were evaluated. Four radiologists independently evaluated the presence of the T2-FLAIR mismatch sign. A 3D convolutional neural network (CNN) model was trained using 50 patients outside the test group (28 astrocytomas and 22 oligodendrogliomas) and transferred to evaluate the T2-FLAIR mismatch lesions in the test group. If the CNN labeled more than 50% of the T2-prolonged lesion area, the result was considered positive. The T1/T2-relaxation times and proton density (PD) derived from SyMRI were measured in both gliomas. Each quantitative parameter (T1, T2, and PD) was compared between gliomas using the Mann-Whitney U-test. Receiver-operating characteristic analysis was used to evaluate the diagnostic performance. RESULTS: The mean sensitivity, specificity, and area under the curve (AUC) of radiologists vs. AI were 76.3% vs. 94.7%; 100% vs. 92.9%; and 0.880 vs. 0.938, respectively. The two types of diffuse gliomas could be differentiated using a cutoff value of 2290/128 ms for a combined 90th percentile of T1 and 10th percentile of T2 relaxation times with 94.4/100% sensitivity/specificity with an AUC of 0.981. CONCLUSION: Compared to the radiologists' assessment using the T2-FLAIR mismatch sign, the AI and the SyMRI assessments increased both sensitivity and objectivity, resulting in improved diagnostic performance in differentiating gliomas.

    DOI: 10.1007/s00234-024-03288-0

    Web of Science

    Scopus

    PubMed

    researchmap

  • Pediatric Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With Combined Central and Peripheral Demyelination

    Horiguchi, A; Kikuchi, K; Horita, H; Ogata, H; Hamano, SI

    PEDIATRIC NEUROLOGY   152   30 - 33   2024.3   ISSN:0887-8994 eISSN:1873-5150

     More details

  • Refresher Course 脳神経関連で役立つMRI撮像技術:arterial spin labeling(ASL)

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   44 ( 3 )   361 - 373   2024.2   ISSN:02850524 eISSN:24321281

     More details

    Publisher:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000005316

    CiNii Research

  • Transclival arteryと左椎骨動脈瘤およびKlippel-Feil症候群を合併した1例

    中村 勇星, 菊地 一史, 樋渡 昭雄, 石神 康生, 栂尾 理, 西村 中, 有村 公一, 吉本 幸司

    Japanese Journal of Radiology   42 ( Suppl. )   49 - 49   2024.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • The cortical high-flow sign of oligodendroglioma, IDH-mutant and 1p/19q-codeleted: comparison between arterial spin labeling and dynamic susceptibility contrast methods. International journal

    Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Yuhei Sangatsuda, Yutaka Fujioka, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology   66 ( 2 )   187 - 192   2024.2   ISSN:0028-3940 eISSN:1432-1920

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: The cortical high-flow sign with the non-enhancing area was reportedly found to be more frequent with oligodendroglioma, IDH-mutant and 1p/19q codeleted (ODG IDHm-codel) than with IDH-wildtype or astrocytoma, IDH-mutant on arterial spin labeling (ASL) in diffuse gliomas. This study aimed to compare the identification rate of the cortical high-flow sign on ASL in patients with ODG IDHm-codel to that on dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI). METHODS: Participants consisted of 32 adult ODG IDHm-codel patients with pathologically confirmed. Subtraction images were generated from paired control and label images on ASL. For DSC, dynamic T2*-weighted perfusion weighted images were obtained after pre-bolus of gadolinium-based contrast agent. Regional cerebral blood flow/volume maps were generated based on the concentration-time curve and arterial input function. Tumor-affecting cortices without contrast enhancement on conventional MR imaging were targeted. The identification rate of the cortical high-flow sign was compared between ASL and DSC using the Pearson's Chi-Square test. RESULTS: Frequency of the cortical high-flow sign was significantly higher on ASL (18/32, 56.3%; p < 0.001) than on DSC (5/32, 15.6%). All cases with the positive cortical high-flow sign on DSC were identified on ASL. CONCLUSION: ASL effectively identifies the cortical high-flow sign in ODG IDHm-codel, surpassing DSC in identification rates.

    DOI: 10.1007/s00234-023-03267-x

    Web of Science

    Scopus

    PubMed

    researchmap

  • Refresher Course 脳神経関連で役立つMRI撮像技術 arterial spin labeling(ASL)

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   44 ( 3 )   361 - 373   2024.2   ISSN:0285-0524 ISBN:9784055200639 eISSN:2432-1281

     More details

    Language:Japanese   Publisher:(株)Gakken  

    本稿では,ASLの原理と臨床応用について概説する.ASLは,動脈血を内因性トレーサーとして使用して脳灌流を画像化する非侵襲的手法であり,脳虚血,脳腫瘍,急性脳炎,脳症など様々な疾患の診断に有用である.また,脳血流量などの脳循環指標の定量化を行うことも可能である他,MRA技術として用いることもできる.

    researchmap

  • Refresher Course 脳神経関連で役立つMRI撮像技術 arterial spin labeling(ASL)

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   44 ( 3 )   361 - 373   2024.2   ISSN:0285-0524 ISBN:9784055200639 eISSN:2432-1281

     More details

    Language:Japanese   Publisher:(株)Gakken  

    本稿では,ASLの原理と臨床応用について概説する.ASLは,動脈血を内因性トレーサーとして使用して脳灌流を画像化する非侵襲的手法であり,脳虚血,脳腫瘍,急性脳炎,脳症など様々な疾患の診断に有用である.また,脳血流量などの脳循環指標の定量化を行うことも可能である他,MRA技術として用いることもできる.

    researchmap

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J00235&link_issn=&doc_id=20240301020020&doc_link_id=10.15105%2FGZ.0000005316&url=https%3A%2F%2Fdoi.org%2F10.15105%2FGZ.0000005316&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Desmoplastic infantile gangliogliomaの1例

    菊地 一史, 石神 康生, 栂尾 理, 山下 孝二, 秦 暢宏, 吉本 幸司

    Japanese Journal of Radiology   42 ( Suppl. )   59 - 59   2024.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • No-wash fluorogenic labeling of proteins for reversible photoswitching in live cells

    Torii, K; Benson, S; Hori, Y; Vendrell, M; Kikuchi, K

    CHEMICAL SCIENCE   15 ( 4 )   1393 - 1401   2024.1   ISSN:2041-6520 eISSN:2041-6539

     More details

  • Performance Evaluation of the Commonly Used Portable Cholesterol Sensors for Telehealth Services in the Unreached Communities

    Islam, R; To, S; Izukura, R; Sato, Y; Nishikitani, M; Kikuchi, K; Yokota, F; Ikeda, S; Islam, R; Ahmed, A; Miyazaki, M; Nakashima, N

    MEDINFO 2023 - THE FUTURE IS ACCESSIBLE   310   309 - 313   2024   ISSN:0926-9630 ISBN:978-1-64368-456-7 eISSN:1879-8365

     More details

  • Diagnostic MR imaging features of hypomyelination of early myelinating structures: A case report. International journal

    Tokiko Abe, Koji Yamashita, Kazufumi Kikuchi, Eriko Hatai, Fumihiko Fujii, Pin Fee Chong, Yasunari Sakai, Hirotomo Saitsu, Ken Inoue, Osamu Togao, Kousei Ishigami

    The neuroradiology journal   19714009231224419 - 19714009231224419   2023.12   ISSN:1971-4009 eISSN:2385-1996

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Hypomyelination of early myelinating structures (HEMS) has recently been defined as a new genetic disorder accompanied by clinical and MR imaging characteristics. However, no studies have focused on diffusion-weighted imaging (DWI) findings of HEMS. We would like to propose a "sheep sign," which is formed by DWI hyperintensity in the medial medullary lamina along with alternating high-low-high (HLH) intensity stripes in the posterior limb of the internal capsule. We believe the presence of the "sheep sign" on DWI in combination with alternating HLH intensity stripes may be a valuable tool for diagnosing HEMS.

    DOI: 10.1177/19714009231224419

    Web of Science

    Scopus

    PubMed

    researchmap

  • Genomic landscape of introgression from the ghost lineage in a gobiid fish uncovers the generality of forces shaping hybrid genomes

    Kato, S; Arakaki, S; Nagano, AJ; Kikuchi, K; Hirase, S

    MOLECULAR ECOLOGY   2023.12   ISSN:0962-1083 eISSN:1365-294X

     More details

  • 【臨床脳腫瘍学-最新の診断・治療と病態-】脳腫瘍の検査・診断 画像診断各論 MRI 代謝画像(CEST)

    栂尾 理, 山下 孝二, 菊地 一史

    日本臨床   81 ( 増刊9 臨床脳腫瘍学 )   168 - 173   2023.12   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

    researchmap

  • 【Neuroradiology Frontier 2024 中枢神経の画像診断最前線 最先端技術で広がる臨床の可能性】脳腫瘍における画像診断技術と臨床の最前線 脳腫瘍における画像診断の最前線 装置,撮像法など技術を中心に

    山下 孝二, 栂尾 理, 菊地 一史, 石神 康生

    INNERVISION   39 ( 1 )   37 - 39   2023.12   ISSN:0913-8919 ISBN:9784910561387

     More details

    Language:Japanese   Publisher:(株)インナービジョン  

    2021年に,WHO中枢神経系腫瘍分類第5版が出版された。最大の特徴として,組織学的所見と比べた分子遺伝学的情報の診断への寄与度が,2016年出版の改訂第4版以上に顕著となっており,腫瘍型分類にも反映されている。これは,主に分子遺伝学的所見による分類が,生命予後や治療反応性と相関することがエビデンスとして示されたことによる。画像診断学は病理組織所見との対比により発展してきたが,今回の腫瘍型分類改訂に伴い,従来の方法では術前の腫瘍型推定が困難な症例にも直面している。それでも,WHO中枢神経系腫瘍分類第5版では,発生部位,組織学的グレーディングおよび分子遺伝学的所見の組み合わせによる統合診断・層別化が重視されており,信号パターン以外にも,局在や広がりが非侵襲的に評価できる画像情報が術前診断に果たす役割は大きい。本稿では,腫瘍の縦緩和時間(T1値),横緩和時間(T2値),プロトン密度(PD)を同時取得する手法として,synthetic MRIの二次元Quantification of Relaxation Times and Proton Density by Multi-Echo acquisition of a saturation-recovery using Turbo spin-Echo Read-out(2D-QRAPMASTER)および3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse(3D-QALAS)法について概説し,pseudo-3D DWI using echo planar imaging with compressed SENSE(EPICS-DWI)を用いたapparent diffusion coefficient(ADC)定量法,最後に,MR spectroscopy(MRS)を用いた分子遺伝学的所見検出の可能性について紹介する。(著者抄録)

    researchmap

  • Reproducibility of quantitative ADC, T1, and T2 measurement on the cerebral cortex: Utility of whole brain echo-planar DWI with compressed SENSE (EPICS-DWI): A pilot study. International journal

    Koji Yamashita, Masami Yoneyama, Kazufumi Kikuchi, Tatsuhiro Wada, Hiroo Murazaki, Hiroaki Watanuki, Ryoji Mikayama, Kousei Ishigami, Osamu Togao

    European journal of radiology open   11   100516 - 100516   2023.12   ISSN:2352-0477 eISSN:2352-0477

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: To assess the reproducibility of ADC, T1, T2, and proton density (PD) measurements on the cortex across the entire brain using high-resolution pseudo-3D diffusion-weighted imaging using echo-planar imaging with compressed SENSE (EPICS-DWI) and 3D quantification with an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) in normal healthy adults. METHODS: Twelve healthy participants (median age, 33 years; range, 28-51 years) were recruited to evaluate the reproducibility of whole-brain EPICS-DWI and synthetic MRI. EPICS-DWI utilizes a compressed SENSE reconstruction framework while maintaining the EPI sampling pattern. The 3D-QALAS sequence is based on multi-acquisition 3D gradient echo, with five acquisitions equally spaced in time, interleaved with a T2 preparation pulse and an inversion pulse. EPICS-DWI (b values, 0 and 1000 s/mm2) and 3D-QALAS sequence with identical voxel size on a 3.0-T MR system were performed twice (for test-retest scan). Intraclass correlation coefficients (ICCs) for ADC, T1, T2, and PD for all parcellated volume of interest (VOI) per subject on scan-rescan tests were calculated to assess reproducibility. Bland-Altman plots were used to investigate discrepancies in ADCs, T1s, T2s, and PDs obtained from the two MR scans. RESULTS: The ICC of ADCs was 0.785, indicating "good" reproducibility. The ICCs of T1s, T2s, and PDs were 0.986, 0.978, and 0.968, indicating "excellent" reproducibility. CONCLUSION: The combination of EPICS-DWI and 3D-QALAS sequences with identical voxel size could reproducible ADC, T1, T2, and PD measurements for the cortex across the entire brain in healthy adults.

    DOI: 10.1016/j.ejro.2023.100516

    Web of Science

    Scopus

    PubMed

    researchmap

  • Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity

    Ochiai, T; Inukai, T; Akiyama, M; Furui, K; Ohue, M; Matsumori, N; Inuki, S; Uesugi, M; Sunazuka, T; Kikuchi, K; Kakeya, H; Sakakibara, Y

    COMMUNICATIONS CHEMISTRY   6 ( 1 )   249   2023.11   ISSN:2399-3669

     More details

  • Arterial Spin Labeling-Based MR Angiography for Cerebrovascular Diseases: Principles and Clinical Applications. International journal

    Osamu Togao, Makoto Obara, Koji Yamashita, Kazufumi Kikuchi, Tatsuhiro Wada, Hiroo Murazaki, Koichi Arimura, Ataru Nishimura, Nobutaka Horie, Kim van de Ven, Marc Van Cauteren, Kousei Ishigami

    Journal of magnetic resonance imaging : JMRI   2023.11   ISSN:1053-1807 eISSN:1522-2586

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Arterial spin labeling (ASL) is a noninvasive imaging technique that labels the proton spins in arterial blood and uses them as endogenous tracers. Brain perfusion imaging with ASL is becoming increasingly common in clinical practice, and clinical applications of ASL for intracranial magnetic resonance angiography (MRA) have also been demonstrated. Unlike computed tomography (CT) angiography and cerebral angiography, ASL-based MRA does not require contrast agents. ASL-based MRA overcomes most of the disadvantages of time-of-flight (TOF) MRA. Several schemes have been developed for ASL-based MRA; the most common method has been pulsed ASL, but more recently pseudo-continuous ASL, which provides a higher signal-to-noise ratio (SNR), has been used more frequently. New methods that have been developed include direct intracranial labeling methods such as velocity-selective ASL and acceleration-selective ASL. MRA using an extremely short echo time (eg, silent MRA) or ultrashort echo-time (TE) MRA can suppress metal susceptibility artifacts and is ideal for patients with a metallic device implanted in a cerebral vessel. Vessel-selective 4D ASL MRA can provide digital subtraction angiography (DSA)-like images. This review highlights the principles, clinical applications, and characteristics of various ASL-based MRA techniques. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 2.

    DOI: 10.1002/jmri.29119

    Web of Science

    Scopus

    PubMed

    researchmap

  • Correction to: Cortical high‑flow sign on arterial spin labeling: a novel biomarker for IDH‑mutation and 1p/19q‑codeletion status in diffuse gliomas without intense contrast enhancement. International journal

    Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Yuhei Sangatsuda, Yutaka Fujioka, Izumi Kinoshita, Makoto Obara, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology   65 ( 11 )   1675 - 1676   2023.11   ISSN:0028-3940 eISSN:1432-1920

  • Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study

    Motomura, Y; Fukuzaki, A; Eto, S; Hirabayashi, N; Gondo, M; Izuno, S; Togao, O; Yamashita, K; Kikuchi, K; Sudo, N; Yoshihara, K

    JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY   42 ( 1 )   18   2023.9   ISSN:1880-6805

     More details

    Language:English   Publisher:Journal of Physiological Anthropology  

    Background: Alexithymia, a personality trait characterized by difficulties in identifying and expressing their emotions despite having a range of emotional experiences, can impact individuals’ stress coping mechanisms. While many studies have investigated brain functions associated with specific tasks in relation to emotion processing, research focusing on resting-state brain functions has been limited. Thus, the aim of this study was to investigate the relationship between alexithymia and brain function by analyzing arterial spin labeling (ASL) data obtained during the resting state. Methods: A brain structural and functional imaging study was conducted on 42 healthy adult men and women using ASL and the 20-item Toronto Alexithymia Scale (TAS-20) questionnaire survey. Cerebral blood flow and functional connectivity values were calculated for regions of interest in the default mode network, saliency network, and central executive network from the ASL data. Correlation analysis was performed with TAS20 scores, and partial correlation analysis was conducted to control for anxiety and depression. Results: The functional connectivity analysis revealed a negative correlation between the functional connectivity of the right insular cortex and left anterior cingulate cortex and the total score of TAS, as well as difficulty identifying feelings and difficulty describing feeling subscores, indicating that the higher the scores, the weaker the functional connectivity between these regions (T = -3.830, p = 0.0013, R = -0.5180). This correlation remained significant even after controlling for anxiety and depression using partial correlation analysis. Conclusion: The present study revealed differences in the activity of the Saliency Network at rest as measured by ASL, which were independent of anxiety and depression, and varied depending on the severity of alexithymia. This functional change may underlie the neural basis of decreased emotional processing observed in alexithymia. These findings may contribute to the elucidation of the neural mechanisms of alexithymia, which can lead to social impairments, and suggest the usefulness of ASL measurement as a biomarker of alexithymia.

    DOI: 10.1186/s40101-023-00336-1

    Web of Science

    Scopus

    PubMed

  • 健常者における失感情症の特徴はsalience network活動性と関連する 動脈スピンラベリング研究(Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study)

    Motomura Yuki, Fukuzaki Ayaka, Eto Sanami, Hirabayashi Naoki, Gondo Motoharu, Izuno Satoshi, Togao Osamu, Yamashita Koji, Kikuchi Kazufumi, Sudo Nobuyuki, Yoshihara Kazufumi

    Journal of Physiological Anthropology   42   1 of 13 - 13 of 13   2023.9   ISSN:1880-6791

     More details

    Language:English   Publisher:(一社)日本生理人類学会  

    失感情症と脳機能の関係について安静時に取得した動脈スピンラベリング(ASL)データの解析による検討を行った。健常成人42人(男性14人、女性28人、平均31.2±9.5歳)を対象として、ASLと20-item Toronto Alexithymia Scale(TAS-20)アンケート調査を用いて脳の構造及び機能イメージング研究を行った。ASLデータから、デフォルトモードネットワーク、salience network及びセントラルエグゼクティブネットワークにおける関心領域に対する脳血流及び機能的結合の値を算出した。機能的結合分析により、右島皮質及び左前帯状皮質の機能的結合と、TAS-20のトータルスコア、感情を特定することの困難さ、感情を語ることの困難さのサブスコアに負の相関がみられた。これらのスコアが高いほどこれらの領域間の機能的結合は弱くなった。この相関は偏相関分析を用いて不安及び抑鬱を調整した後でも有意であった。

  • Cortical high-flow sign on arterial spin labeling: a novel biomarker for IDH-mutation and 1p/19q-codeletion status in diffuse gliomas without intense contrast enhancement. International journal

    Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Yuhei Sangatsuda, Yutaka Fujioka, Izumi Kinoshita, Makoto Obara, Koji Yoshimoto, Kousei Ishigami

    Neuroradiology   65 ( 9 )   1415 - 1418   2023.9   ISSN:0028-3940 eISSN:1432-1920

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This study aimed to investigate whether arterial spin labeling (ASL) features allow differentiation of oligodendroglioma, IDH-mutant and 1p/19q-codeleted (IDHm-codel) from diffuse glioma with IDH-wildtype (IDHw) or astrocytoma, IDH-mutant (IDHm-noncodel). Participants comprised 71 adult patients with pathologically confirmed diffuse glioma, classified as IDHw, IDHm-noncodel, or IDHm-codel. Subtraction images were generated from paired-control/label images on ASL and used to assess the presence of a cortical high-flow sign. The cortical high-flow sign was defined as increased ASL signal intensity within the tumor-affecting cerebral cortex compared with normal-appearing cortex. Regions without contrast enhancement on conventional MR imaging were targeted. The frequency of the cortical high-flow sign on ASL was compared among IDHw, IDHm-noncodel, and IDHm-codel. As a result, the frequency of the cortical high-flow sign was significantly higher for IDHm-codel than for IDHw or IDHm-noncodel. In conclusion, the cortical high-flow sign could represent a hallmark of oligodendroglioma, IDH-mutant, and 1p/19q-codeleted without intense contrast enhancement.

    DOI: 10.1007/s00234-023-03186-x

    Web of Science

    Scopus

    PubMed

    researchmap

  • 特集 WHO脳腫瘍分類 第5版 徹底解説 Case-based review 4. Diffuse hemispheric glioma, H3 G34-mutant

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   43 ( 10 )   988 - 992   2023.8   ISSN:02850524 eISSN:24321281

     More details

    Publisher:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000004785

    CiNii Research

  • 特集 WHO脳腫瘍分類 第5版 徹底解説 Case-based review 7. High-grade astrocytoma with piloid features

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生, 黒川 遼, 森谷 聡男

    画像診断   43 ( 10 )   998 - 1000   2023.8   ISSN:02850524 eISSN:24321281

     More details

    Publisher:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000004788

    CiNii Research

  • Predicting TERT promoter mutation status using 1H-MR spectroscopy and stretched-exponential model of diffusion-weighted imaging in IDH-wildtype diffuse astrocytic glioma without intense enhancement. International journal

    Koji Yamashita, Ryusuke Hatae, Kazufumi Kikuchi, Daisuke Kuga, Nobuhiro Hata, Hidetaka Yamamoto, Makoto Obara, Koji Yoshimoto, Kousei Ishigami, Osamu Togao

    Neuroradiology   65 ( 8 )   1205 - 1213   2023.8   ISSN:0028-3940 eISSN:1432-1920

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Isocitrate dehydrogenase (IDH)-wildtype diffuse astrocytic glioma with telomerase reverse transcriptase (TERT) promoter mutation is defined as glioblastoma by the WHO 2021 criteria, revealing that TERT promotor mutation is highly associated with tumor aggressiveness. The aim of this study was to identify features from MR spectroscopy (MRS) and multi-exponential models of DWI distinguishing wild-type TERT (TERTw) from TERT promoter mutation (TERTm) in IDH-wildtype diffuse astrocytic glioma. METHODS: Participants comprised 25 adult patients with IDH-wildtype diffuse astrocytic glioma. Participants were classified into TERTw and TERTm groups. Point-resolved spectroscopy sequences were used for MRS data acquisition. DWI was performed with 13 different b-factors. Peak height ratios of NAA/Cr and Cho/Cr were calculated from MRS data. Mean apparent diffusion coefficient (ADC), perfusion fraction (f), diffusion coefficient (D), pseudo-diffusion coefficient (D*), distributed diffusion coefficient (DDC), and heterogeneity index (α) were obtained using multi-exponential models from DWI data. Each parameter was compared between TERTw and TERTm using the Mann-Whitney U test. Correlations between parameters derived from MRS and DWI were also evaluated. RESULTS: NAA/Cr and Cho/Cr were both higher for TERTw than for TERTm. The α of TERTw was smaller than that of TERTm, while the f of TERTw was higher than that of TERTm. NAA/Cr correlated negatively with α, but not with other DWI parameters. Cho/Cr did not show significant correlations with any DWI parameters. CONCLUSION: The combination of NAA/Cr and α may have merit in clinical situation to predict the TERT mutation status of IDH-wildtype diffuse astrocytic glioma without intense enhancement.

    DOI: 10.1007/s00234-023-03177-y

    Web of Science

    Scopus

    PubMed

    researchmap

  • 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】High-grade astrocytoma with piloid features

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生, 黒川 遼, 森谷 聡男

    画像診断   43 ( 10 )   998 - 1000   2023.8   ISSN:0285-0524 ISBN:9784055200103 eISSN:2432-1281

     More details

    Language:Japanese   Publisher:(株)Gakken  

    researchmap

  • 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】Diffuse hemispheric glioma, H3 G34-mutant

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   43 ( 10 )   988 - 992   2023.8   ISSN:0285-0524 ISBN:9784055200103 eISSN:2432-1281

     More details

    Language:Japanese   Publisher:(株)Gakken  

    researchmap

  • Supramaximal resectionは皮質神経膠腫患者の生存期間を延長させる 容積測定による研究(Supramaximal Resection Can Prolong the Survival of Patients with Cortical Glioblastoma: A Volumetric Study)

    Otsuji Ryosuke, Hata Nobuhiro, Funakoshi Yusuke, Kuga Daisuke, Togao Osamu, Hatae Ryusuke, Sangatsuda Yuhei, Fujioka Yutaka, Takigawa Kosuke, Sako Aki, Kikuchi Kazufumi, Yoshitake Tadamasa, Yamamoto Hidetaka, Mizoguchi Masahiro, Yoshimoto Koji

    Neurologia medico-chirurgica   63 ( 8 )   364 - 374   2023.8   ISSN:0470-8105

     More details

    Language:English   Publisher:(一社)日本脳神経外科学会  

    膠芽腫患者を対象とした後ろ向き研究を実施し、FLAIR病変切除率を評価することで、supramaximal resection(SMR)の臨床効果について検討した。2006年12月~2018年8月に神経膠腫と診断された成人患者のうち、肉眼的全切除(GTR)が施行された成人33例(年齢中央値64歳、男性19例)を対象とした。評価項目は腫瘍切除率(手術前後のFLAIRおよびガドリニウム強調T1強調画像の腫瘍体積を3D画像体積分析装置により測定)、SMR率(0%から10%刻み)などとした。腫瘍を皮質灰白質との接触により、皮質群23例(SMR 8例、GTR 15例)、深在性群10例(SMR 4例、全切除6例)に分けて検討した。その結果、SMR閾値が30%以上の場合に全生存期間の改善が観察された。皮質群ではGTRと比較してSMRで全生存期間が延長する傾向が認められた(69.6ヵ月対22.1ヵ月)。一方、深在群ではGTRと比較してSMRで全生存期間が有意に短縮していた(10.2ヵ月対27.9ヵ月、p=0.0221)。以上から、FLAIR病変のsupramaximal resectionは神経膠腫患者の生存期間を延長可能であることが示された。

  • Supramaximal Resection Can Prolong the Survival of Patients with Cortical Glioblastoma: A Volumetric Study

    Ryosuke Otsuji, Nobuhiro Hata, Yusuke Funakoshi, Daisuke Kuga, Osamu Togao, Ryusuke Hatae, Yuhei Sangatsuda, Yutaka Fujioka, Kosuke Takigawa, Aki Sako, Kazufumi Kikuchi, Tadamasa Yoshitake, Hidetaka Yamamoto, Masahiro Mizoguchi, Koji Yoshimoto

    NEUROLOGIA MEDICO-CHIRURGICA   63 ( 8 )   364 - 374   2023.7   ISSN:04708105 eISSN:13498029

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japan Neurosurgical Society  

    <p>We aimed to retrospectively determine the resection rate of fluid-attenuated inversion recovery (FLAIR) lesions to evaluate the clinical effects of supramaximal resection (SMR) on the survival of patients with glioblastoma (GBM). Thirty-three adults with newly diagnosed GBM who underwent gross total tumor resection were enrolled. The tumors were classified into cortical and deep-seated groups according to their contact with the cortical gray matter. Pre- and postoperative FLAIR and gadolinium-enhanced T1-weighted imaging tumor volumes were measured using a three-dimensional imaging volume analyzer, and the resection rate was calculated. To evaluate the association between SMR rate and outcome, we subdivided patients whose tumors were totally resected into the SMR and non-SMR groups by moving the threshold value of SMR in 10% increments from 0% and compared their overall survival (OS) change. An improvement in OS was observed when the threshold value of SMR was 30% or more. In the cortical group (n = 23), SMR (n = 8) tended to prolong OS compared with gross total resection (GTR) (n = 15), with the median OS of 69.6 and 22.1 months, respectively (p = 0.0945). Contrastingly, in the deep-seated group (n = 10), SMR (n = 4) significantly shortened OS compared with GTR (n = 6), with median OS of 10.2 and 27.9 months, respectively (p = 0.0221). SMR could help prolong OS in patients with cortical GBM when 30% or more volume reduction is achieved in FLAIR lesions, although the impact of SMR for deep-seated GBM must be validated in larger cohorts.</p>

    DOI: 10.2176/jns-nmc.2022-0351

    Web of Science

    Scopus

    PubMed

    CiNii Research

    researchmap

  • The T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase wild-type A case report. International journal

    Shunsuke Nishimura, Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Hidetaka Yamamoto, Koji Yoshimoto, Kousei Ishigami

    Acta radiologica open   12 ( 6 )   20584601231184565 - 20584601231184565   2023.6   ISSN:2058-4601 eISSN:2058-4601

     More details

    Language:English  

    We present a case of the T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase (IDH)-wild type. The T2-FLAIR mismatch sign is known as a highly specific imaging finding of astrocytoma, IDH-mutant. Meanwhile, IDH-wildtype diffuse astrocytic gliomas with telomerase reverse transcriptase (TERT) promoter mutation in adults are defined as glioblastoma in the 2021 World Health Organization Classification of Tumors of the Central Nervous System, fifth edition (2021 WHO classification), which underscores the importance of molecular information in central nervous system tumors. This indicates even glioblastoma, IDH-wild type may be masquerading as lower-grade glioma in histology. The reasons for the discrepancy between tumors with less aggressive histology and poor prognosis caused by telomerase reverse transcriptase promoter mutation of IDH-wildtype diffuse glioma remain unclear. However, glioblastoma, IDH-wildtype should be considered as a potential differential diagnosis even in patients with the T2-FLAIR mismatch sign in diffuse gliomas.

    DOI: 10.1177/20584601231184565

    Web of Science

    PubMed

    researchmap

  • Sleep quality and temperament in association with autism spectrum disorder among infants in Japan

    Kikuchi, K; Michikawa, T; Morokuma, S; Hamada, N; Suetsugu, Y; Ikeda, S; Nakahara, K; Kato, K; Ochiai, M; Shibata, E; Tsuji, M; Shimono, M; Kawamoto, T; Ohga, S; Kusuhara, K

    COMMUNICATIONS MEDICINE   3 ( 1 )   82   2023.6   ISSN:2730-664X

     More details

  • Editorial: Challenges of maternal and child health after the COVID-19 pandemic

    Kikuchi, K; Nanishi, K; Yi, SY; Yasuoka, J

    FRONTIERS IN PUBLIC HEALTH   11   1224093   2023.6   eISSN:2296-2565

     More details

  • Visualization of multiple localizations of GLUT4 by fluorescent probes of PYP-tag with designed unnatural warhead

    Nishiura, M; Hori, Y; Umeno, M; Kikuchi, K

    CHEMICAL SCIENCE   14 ( 22 )   5925 - 5935   2023.6   ISSN:2041-6520 eISSN:2041-6539

     More details

  • Persistent Fluorescence Switching of a Probe Using a Photochromic Quencher with High Photostability Assisted by Protein-Surface Modification

    Torii, K; Hori, Y; Kikuchi, K

    ANALYTICAL CHEMISTRY   95 ( 23 )   8834 - 8841   2023.5   ISSN:0003-2700 eISSN:1520-6882

     More details

  • Impact of oral intervention on the oral and overall health of children living with HIV in Cambodia: a randomized controlled trial

    Kikuchi, K; Tuot, S; Yasuoka, J; Murayama, M; Okawa, S; Shibanuma, A; Nanishi, K; Eng, S; Huot, C; Yi, SY

    BMC MEDICINE   21 ( 1 )   162   2023.4   ISSN:1741-7015

     More details

  • 膿瘍を伴った小児発生のPapillary Craniopharyngiomaの1例

    高木 勝弘, 菊地 一史, 樋渡 昭雄, 石神 康生, 栂尾 理, 空閑 太亮, 溝口 昌弘, 山元 英崇, 岩城 徹

    Japanese Journal of Radiology   41 ( Suppl. )   56 - 56   2023.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • 膿瘍を伴った小児発生のPapillary Craniopharyngiomaの1例

    高木 勝弘, 菊地 一史, 樋渡 昭雄, 石神 康生, 栂尾 理, 空閑 太亮, 溝口 昌弘, 山元 英崇, 岩城 徹

    Japanese Journal of Radiology   41 ( Suppl. )   56 - 56   2023.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • 左眼窩内alveolar soft part sarcomaの1例

    小田 剛, 菊地 一史, 樋渡 昭雄, 馬場 眞吾, 石神 康生, 栂尾 理, 田邉 美香, 溝口 昌弘, 山元 英崇

    Japanese Journal of Radiology   41 ( Suppl. )   65 - 65   2023.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • 左眼窩内alveolar soft part sarcomaの1例

    小田 剛, 菊地 一史, 樋渡 昭雄, 馬場 眞吾, 石神 康生, 栂尾 理, 田邉 美香, 溝口 昌弘, 山元 英崇

    Japanese Journal of Radiology   41 ( Suppl. )   65 - 65   2023.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • Atomically Resolved Scanning Tunneling Microscopy of Cleaved Chalcopyrite Surface

    Kikuchi, K; Kurokawa, S; Taninouchi, YK

    MATERIALS TRANSACTIONS   64 ( 12 )   2748 - 2753   2023   ISSN:1345-9678 eISSN:1347-5320

  • 特集 ビギナーのための頭部画像診断 -Q&Aアプローチ- 2023 解剖・正常変異-部位別の鑑別診断- 硬膜外腔,硬膜下腔,くも膜下腔はそれぞれMRIでどのように描出されますか?

    菊地 一史

    画像診断   43 ( 1 )   48 - 49   2022.12   ISSN:02850524 eISSN:24321281

     More details

    Publisher:学研メディカル秀潤社  

    DOI: 10.15105/gz.0000004316

    CiNii Research

  • Grading of gliomas using 3D CEST imaging with compressed sensing and sensitivity encoding. International journal

    Tatsuhiro Wada, Osamu Togao, Chiaki Tokunaga, Masahiro Oga, Kazufumi Kikuchi, Koji Yamashita, Hidetaka Yamamoto, Masami Yoneyama, Koji Kobayashi, Toyoyuki Kato, Kousei Ishigami, Hidetake Yabuuchi

    European journal of radiology   158   110654 - 110654   2022.12   ISSN:0720-048X eISSN:1872-7727

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: We evaluated the usefulness of three-dimensional (3D) chemical exchange saturation transfer (CEST) imaging with compressed sensing and sensitivity encoding (CS-SENSE) for differentiating low-grade gliomas (LGGs) from high-grade gliomas (HGGs). METHODS: We evaluated 28 patients (mean age 51.0 ± 13.9 years, 13 males, 15 females) including 12 with LGGs and 16 with HGGs, all acquired using a 3 T magnetic resonance (MR) scanner. Nine slices were acquired for 3D CEST imaging, and one slice was acquired for two-dimensional (2D) CEST imaging. Two radiological technologists each drew a region of interest (ROI) surrounding the high-signal-intensity area(s) on the fluid-attenuated inversion recovery image of each patient. We compared the magnetization transfer ratio asymmetry (MTRasym) at 3.5 ppm in the tumors among the (i) single-slice 2D CEST imaging ("2D"), (ii) all tumor slices of the 3D CEST imaging (3Dall), and (iii) a representative tumor slice of 3D CEST imaging (maximum signal intensity [3Dmax]). The relationship between the MTRasym at 3.5 ppm values measured by these three methods and the Ki-67 labeling index (LI) of the tumors was assessed. Diagnostic performance was evaluated with a receiver operating characteristic analysis. The Ki-67LI and MTRasym at 3.5 ppm values were compared between the LGGs and HGGs. RESULTS: A moderate positive correlation between the MTRasym at 3.5 ppm and the Ki-67LI was observed with all three methods. All methods proved a significantly larger MTRasym at 3.5 ppm for the HGGs compared to the LGGs. All methods showed equivalent diagnostic performance. The signal intensity varied depending on the slice position in each case. CONCLUSIONS: The 3D CEST imaging provided the MTRasym at 3.5 ppm for each slice cross-section; its diagnostic performance was also equivalent to that of 2D CEST imaging.

    DOI: 10.1016/j.ejrad.2022.110654

    Web of Science

    Scopus

    PubMed

    researchmap

  • Telehealth Care for Mothers and Infants to Improve the Continuum of Care: Protocol for a Quasi-Experimental Study

    Kikuchi, K; Islam, R; Sato, Y; Nishikitani, M; Izukura, R; Jahan, N; Yokota, F; Ikeda, S; Sultana, N; Nessa, M; Nasir, M; Ahmed, A; Kato, K; Morokuma, S; Nakashima, N

    JMIR RESEARCH PROTOCOLS   11 ( 12 )   e41586   2022.12   ISSN:1929-0748

     More details

    Language:English  

    DOI: 10.2196/41586

    Web of Science

    PubMed

  • Assessment of cerebral perfusion in moyamoya disease with dynamic pseudo-continuous arterial spin labeling using a variable repetition time scheme with optimized background suppression. Reviewed International journal

    Osamu Togao, Makoto Obara, Koji Yamashita, Kazufumi Kikuchi, Koichi Arimura, Ataru Nishimura, Akira Nakamizo, Tatsuhiro Wada, Chiaki Tokunaga, Ryoji Mikayama, Yasuo Yamashita, Hiroshi Hamano, Marc Van Cauteren, Kousei Ishigami, Shingo Baba

    Neuroradiology   65 ( 3 )   529 - 538   2022.11   ISSN:0028-3940 eISSN:1432-1920

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Accurate assessment of cerebral perfusion in moyamoya disease is necessary to determine the indication for treatment. We aimed to investigate the usefulness of dynamic PCASL using a variable TR scheme with optimized background suppression in the evaluation of cerebral perfusion in moyamoya disease. METHODS: We retrospectively analyzed the images of 24 patients (6 men and 18 women, mean age 31.4 ± 18.2 years) with moyamoya disease; each of whom was imaged with both dynamic PCASL using the variable-TR scheme and 123IMP SPECT with acetazolamide challenge. ASL dynamic data at 10 phases are acquired by changing the LD and PLD. The background suppression timing was optimized for each phase. CBF and ATT were measured with ASL, and CBF and CVR to an acetazolamide challenge were measured with SPECT. RESULTS: A significant moderate correlation was found between the CBF measured by dynamic PCASL and that by SPECT (r = 0.53, P < 0.001). The CBF measured by dynamic PCASL (52.5 ± 13.3 ml/100 mg/min) was significantly higher than that measured by SPECT (43.0 ± 12.6 ml/100 mg/min, P < 0.001). The ATT measured by dynamic PCASL showed a significant correlation with the CVR measured by SPECT (r = 0.44, P < 0.001). ATT was significantly longer in areas where the CVR was impaired (CVR < 18.4%, ATT = 1812 ± 353 ms) than in areas where it was preserved (CVR > 18.4%, ATT = 1301 ± 437 ms, P < 0.001). The ROC analysis showed a moderate accuracy (AUC = 0.807, sensitivity = 87.7%, specificity = 70.4%) when the cutoff value of ATT was set at 1518 ms. CONCLUSION: Dynamic PCASL using this scheme was found to be useful for assessing cerebral perfusion in moyamoya disease.

    DOI: 10.1007/s00234-022-03095-5

    Web of Science

    Scopus

    PubMed

    researchmap

  • Association of sleep quality with temperament among one-month-old infants in The Japan Environment and Children's Study

    Kikuchi, K; Michikawa, T; Morokuma, S; Hamada, N; Suetsugu, Y; Nakahara, K; Kato, K; Sanefuji, M; Shibata, E; Tsuji, M; Shimono, M; Kawamoto, T; Ohga, S; Kusuhara, K

    PLOS ONE   17 ( 9 )   e0274610   2022.9   ISSN:1932-6203

     More details

  • 'Paradoxical'cortical high-flow sign Oligodendroglioma検出の新たな指標

    山下 孝二, 栂尾 理, 菊地 一史, 空閑 太亮, 吉本 幸司, 石神 康生

    日本医学放射線学会秋季臨床大会抄録集   59回   S357 - S357   2022.9   ISSN:0048-0428 eISSN:1347-7951

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • Salivary gland polymorphous adenocarcinoma: Clinicopathological features and gene alterations in 36 Japanese patients

    Fukumura, M; Ishibashi, K; Nakaguro, M; Nagao, T; Saida, K; Urano, M; Tanigawa, M; Hirai, H; Yagyuu, T; Kikuchi, K; Yada, N; Sugita, Y; Miyabe, M; Hasegawa, S; Goto, M; Yamamoto, H; Ohuchi, T; Kusafuka, K; Ogawa, I; Suzuki, H; Notohara, K; Shimoda, M; Tada, Y; Kirita, T; Takata, T; Morinaga, S; Maeda, H; Warnakulasuriya, S; Miyabe, S; Nagao, T

    JOURNAL OF ORAL PATHOLOGY & MEDICINE   51 ( 8 )   710 - 720   2022.9   ISSN:0904-2512 eISSN:1600-0714

     More details

  • EPICS-DWIおよびsynthetic MR画像を用いた全脳皮質領域のADC、T1およびT2値の再現性

    山下 孝二, 栂尾 理, 米山 正己, 菊地 一史, 石神 康生

    断層映像研究会雑誌   49 ( 2 )   37 - 37   2022.9   ISSN:0914-8663 eISSN:2187-0489

     More details

    Language:Japanese   Publisher:断層映像研究会  

    researchmap

  • 【Step up MRI 2022 MRI研究の最新動向&領域別MRI技術の臨床応用とトピックス】MRI研究の最新動向 Arterial spin labeling MRI技術の最新動向

    栂尾 理, 山下 孝二, 菊地 一史, 小原 真, 石神 康生

    INNERVISION   37 ( 9 )   4 - 8   2022.8   ISSN:0913-8919 ISBN:9784910561172

     More details

    Language:Japanese   Publisher:(株)インナービジョン  

    arterial spin labeling(以下、ASL)は動脈血中のプロトンのスピンをラベルし、それを内因性トレーサーとして画像化に利用する非侵襲的手法である。近年、臨床現場では、pseudo-continuous ASL(以下、pCASL)の導入により、ASLを用いた脳灌流画像の使用が普及しつつある。臨床で用いられるASLは、通常1つのlabel duration(以下、LD)と1つのpost-labeling delay(以下、PLD)の組み合わせによる1時相での撮像であるが、ラベルされた血液がラベル面から脳組織に到達するまでの時間(arterial transit time:ATT)が長く、ラベルされた血液が到達していない場合には、正しく脳血流量(cerebral blood flow:CBF)を評価することができない。最近では、多時相撮像を行うことでATTの影響を考慮したCBFの定量化が行われるようになってきている。また、ASLは脳灌流画像のみでなく、MR angiography(以下、MRA)にも応用することができる。臨床で用いられるtime of flight(以下、TOF)-MRAは撮像スラブへのinflow効果に依存しているため、上方向以外の血流、乱流、遅い血流などの描出は不良であることや、時間情報を持っていないという欠点がある。ASLによる4D-MRAは、TOF-MRAの弱点を克服しつつ時間情報を有する画像法である。さらに、血管選択的画像も取得することができ、選択的digital subtraction angiography(以下、DSA)の代替となるような画像も得られる。本稿では、多時相ASL灌流画像とASLを用いた4D-MRAの開発の最近の動向と、それらの臨床的有用性を概説する。(著者抄録)

    researchmap

  • Portable Health Clinic System for Maternal and Child Health Care in COVID-19 Pandemic Situation.

    Islam R, Kikuchi K, Sato Y, Izukura R, Nishikitani M, Jahan N, Nessa M, Yokota F, Ahmed A, Nakashima N

    Studies in health technology and informatics   295   213 - 216   2022.6   ISSN:0926-9630

     More details

    Language:English  

    DOI: 10.3233/SHTI220700

    PubMed

  • Standardization of Personal Health Records in the Portable Health Clinic System.

    Islam R, Yokota F, Kikuchi K, Nishikitani M, Izukura R, Sato Y, Rahman M, Sultana N, Nessa M, Ahmed A, Nakashima N

    Studies in health technology and informatics   290   163 - 167   2022.6   ISSN:0926-9630

     More details

    Language:English  

    DOI: 10.3233/SHTI220053

    PubMed

  • Quantitative relaxometry using synthetic MRI could be better than T2-FLAIR mismatch sign for differentiation of IDH-mutant gliomas: a pilot study Reviewed International journal

    Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Yoshitomo Kikuchi, Daisuke Kuga, Nobuhiro Hata, Masahiro Mizoguchi, Hidetaka Yamamoto, Toru Iwaki, Akio Hiwatashi, Kousei Ishigami

    scientific reports   12 ( 1 )   9197   2022.6   ISSN:2045-2322 eISSN:2045-2322

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This study aimed to determine whether quantitative relaxometry using synthetic magnetic resonance imaging (SyMRI) could differentiate between two diffuse glioma groups with isocitrate dehydrogenase (IDH)-mutant tumors, achieving an increased sensitivity compared to the qualitative T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign. Between May 2019 and May 2020, thirteen patients with IDH-mutant diffuse gliomas, including seven with astrocytomas and six with oligodendrogliomas, were evaluated. Five neuroradiologists independently evaluated the presence of the qualitative T2-FLAIR mismatch sign. Interrater agreement on the presence of the T2-FLAIR mismatch sign was calculated using the Fleiss kappa coefficient. SyMRI parameters (T1 and T2 relaxation times and proton density) were measured in the gliomas and compared by the Mann–Whitney U test. Receiver operating characteristic curve analysis was used to evaluate the diagnostic performance. The sensitivity, specificity, and kappa coefficient were 57.1%, 100%, and 0.60, respectively, for the qualitative T2-FLAIR mismatch sign. The two types of diffuse gliomas could be differentiated using a cutoff value of 178 ms for the T2 relaxation time parameter with 100% sensitivity, specificity, accuracy, and positive and negative predictive values, with an area under the curve (AUC) of 1.00. Quantitative relaxometry using SyMRI could differentiate astrocytomas from oligodendrogliomas, achieving an increased sensitivity and objectivity compared to the qualitative T2-FLAIR mismatch sign.

    DOI: 10.1038/s41598-022-13036-0

    Web of Science

    Scopus

    PubMed

    researchmap

  • Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study.

    Kuroda N, Kubota T, Horinouchi T, Ikegaya N, Kitazawa Y, Kodama S, Kuramochi I, Matsubara T, Nagino N, Neshige S, Soga T, Takayama Y, Sone D, IMPACT-J EPILEPSY (In-depth Multicenter analysis during Pandemic of Covid19 Throughout Japan for Epilepsy practice) study group, Kanemoto K, Ikeda A, Terada K, Goji H, Ohara S, Hagiwara K, Kamada T, Iida K, Ishikawa N, Shiraishi H, Iwata O, Sugano H, Iimura Y, Higashi T, Hosoyama H, Hanaya R, Shimotake A, Kikuchi T, Yoshida T, Shigeto H, Yokoyama J, Mukaino T, Kato M, Sekimoto M, Mizobuchi M, Aburakawa Y, Iwasaki M, Nakagawa E, Iwata T, Tokumoto K, Nishida T, Takahashi Y, Kikuchi K, Matsuura R, Hamano SI, Fujimoto A, Enoki H, Tomoto K, Watanabe M, Takubo Y, Fukuchi T, Nakamoto H, Kubota Y, Kunii N, Shirota Y, Ishikawa E, Nakasato N, Maehara T, Inaji M, Takagi S, Enokizono T, Masuda Y, Hayashi T

    Epilepsia open   7 ( 3 )   431 - 41   2022.5

     More details

    Language:English  

    DOI: 10.1002/epi4.12616

    PubMed

  • Gamma distribution model of diffusion MRI for evaluating the isocitrate dehydrogenase mutation status of glioblastomas

    Hanae Takase, Osamu Togao, Kazufumi Kikuchi, Nobuhiro Hata, Ryusuke Hatae, Toru Chikui, Kenji Tokumori, Yukiko Kami, Daisuke Kuga, Yuhei Sangatsuda, Masahiro Mizoguchi, Akio Hiwatashi, Kousei Ishigami

    British Journal of Radiology   95 ( 1133 )   2022.5

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1259/bjr.20210392

  • A deep convolutional neural network-based automatic detection of brain metastases with and without blood vessel suppression Reviewed International journal

    Kikuchi, Yoshitomo; Togao, Osamu; Kikuchi, Kazufumi; Momosaka, Daichi; Obara, Makoto; Van Cauteren, Marc; Fischer, Alexander; Ishigami, Kousei; Hiwatashi, Akio

    EUROPEAN RADIOLOGY   32 ( 5 )   2998 - 3005   2022.5   ISSN:0938-7994 eISSN:1432-1084

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Objectives: To develop an automated model to detect brain metastases using a convolutional neural network (CNN) and volume isotropic simultaneous interleaved bright-blood and black-blood examination (VISIBLE) and to compare its diagnostic performance with the observer test. Methods: This retrospective study included patients with clinical suspicion of brain metastases imaged with VISIBLE from March 2016 to July 2019 to create a model. Images with and without blood vessel suppression were used for training an existing CNN (DeepMedic). Diagnostic performance was evaluated using sensitivity and false-positive results per case (FPs/case). We compared the diagnostic performance of the CNN model with that of the twelve radiologists. Results: Fifty patients (30 males and 20 females; age range 29–86 years; mean 63.3 ± 12.8 years; a total of 165 metastases) who were clinically diagnosed with brain metastasis on follow-up were used for the training. The sensitivity of our model was 91.7%, which was higher than that of the observer test (mean ± standard deviation; 88.7 ± 3.7%). The number of FPs/case in our model was 1.5, which was greater than that by the observer test (0.17 ± 0.09). Conclusions: Compared to radiologists, our model created by VISIBLE and CNN to diagnose brain metastases showed higher sensitivity. The number of FPs/case by our model was greater than that by the observer test of radiologists; however, it was less than that in most of the previous studies with deep learning. Key Points: • Our convolutional neural network based on bright-blood and black-blood examination to diagnose brain metastases showed a higher sensitivity than that by the observer test. • The number of false-positives/case by our model was greater than that by the previous observer test; however, it was less than those from most previous studies. • In our model, false-positives were found in the vessels, choroid plexus, and image noise or unknown causes.

    DOI: 10.1007/s00330-021-08427-2

    Web of Science

    Scopus

    PubMed

    researchmap

  • 【免疫性神経疾患(第2版)-基礎・臨床の最新知見-】診療に役立つ免疫性末梢神経疾患の画像検査とその解釈

    樋渡 昭雄, 栂尾 理, 菊地 一史

    日本臨床   80 ( 増刊5 免疫性神経疾患 )   78 - 82   2022.5   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

    researchmap

  • English version of guidelines for the management of asteatosis 2021 in Japan

    Saeki, H; Tsunemi, Y; Arai, S; Ichiyama, S; Katoh, N; Kikuchi, K; Kubo, A; Terui, T; Nakahara, T; Futamura, M; Murota, H; Igarashi, A

    JOURNAL OF DERMATOLOGY   49 ( 3 )   E77 - E90   2022.3   ISSN:0385-2407 eISSN:1346-8138

     More details

  • Protein Needles Designed to Self-Assemble through Needle Tip Engineering

    Kikuchi, K; Fukuyama, T; Uchihashi, T; Furuta, T; Maeda, YT; Ueno, T

    SMALL   18 ( 10 )   e2106401   2022.3   ISSN:1613-6810 eISSN:1613-6829

     More details

  • 【最新臨床脳卒中学(第2版)下-最新の診断と治療-】脳梗塞総論 脳梗塞の画像診断

    栂尾 理, 樋渡 昭雄, 菊地 一史, 石神 康生

    日本臨床   80 ( 増刊2 最新臨床脳卒中学(下) )   13 - 21   2022.2   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

    researchmap

  • VISIBLE法と深層学習を利用した転移性脳腫瘍の検出

    菊池 嘉朋, 栂尾 理, 菊地 一史, 桃坂 大地, 樋渡 昭雄, 小原 真

    Japanese Journal of Radiology   40 ( Suppl. )   56 - 56   2022.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • VISIBLE法と深層学習を利用した転移性脳腫瘍の検出

    菊池 嘉朋, 栂尾 理, 菊地 一史, 桃坂 大地, 樋渡 昭雄, 小原 真

    Japanese Journal of Radiology   40 ( Suppl. )   56 - 56   2022.2   ISSN:1867-1071 eISSN:1867-108X

     More details

    Language:Japanese   Publisher:(公社)日本医学放射線学会  

    researchmap

  • Portable health clinic COVID-19 system for remote patient follow-up ensuring clinical safety.

    Islam R, Yokota F, Nishikitani M, Kikuchi K, Sato Y, Izukura R, Rahman MM, Chowdhury MR, Ahmed A, Nakashima N

    Computer methods and programs in biomedicine update   2   100061   2022

     More details

    Language:English  

    DOI: 10.1016/j.cmpbup.2022.100061

    PubMed

  • Women's health status before and during the COVID-19 pandemic in rural Bangladesh: A prospective longitudinal study

    Kikuchi, K; Islam, R; Nishikitani, M; Sato, Y; Izukura, R; Yokota, F; Khan, NJ; Nessa, M; Ahmed, A; Morokuma, S; Nakashima, N

    PLOS ONE   17 ( 5 )   e0266141   2022   ISSN:1932-6203

     More details

  • Papillary craniopharyngioma coexisting with an intratumoral abscess in a pediatric patient: A case report and review of the literature. International journal

    Katsuhiro Takagi, Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Yuhei Sangatsuda, Daisuke Kuga, Masahiro Mizoguchi, Hidetaka Yamamoto, Toru Iwaki, Kousei Ishigami

    Acta radiologica open   10 ( 7 )   20584601211030661 - 20584601211030661   2021.7

     More details

    Language:English  

    DOI: 10.1177/20584601211030661

  • Diagnostic accuracy for the epileptogenic zone detection in focal epilepsy could be higher in FDG-PET/MRI than in FDG-PET/CT Reviewed International journal

    Kazufumi Kikuchi 1, Osamu Togao 1, Koji Yamashita 1, Daichi Momosaka 1, Tomohiro Nakayama 2, Yoshiyuki Kitamura 1, Yoshitomo Kikuchi 1, Shingo Baba 1, Koji Sagiyama 1, Keisuke Ishimatsu 1, Ryotaro Kamei 2, Nobutaka Mukae 3, Koji Iihara 3, Satoshi O Suzuki 4, Toru Iwaki 4, Akio Hiwatashi 5 6

    Eur Radiol   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-020-07389-1

  • Correlations of amide proton transferweighted MRI of cerebral infarction with clinico-radiological findings Reviewed

    Daichi Momosaka, Osamu Togao, Kazufumi Kikuchi, Yoshitomo Kikuchi, Yoshinobu Wakisaka, Akio Hiwatashi

    PloS one   15 ( 8 August )   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0237358

  • A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI Reviewed

    Daichi Momosaka, Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Hirofumi Tomiyama, Tomohiro Nakao, Keitaro Murayama, Yuriko Suzuki, Hiroshi Honda

    PloS one   15 ( 7 July )   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0236512

  • Differentiation of high-grade from low-grade diffuse gliomas using diffusion-weighted imaging a comparative study of mono-, bi-, and stretched-exponential diffusion models Reviewed

    Masaoki Kusunoki, Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Daichi Momosaka, Yoshitomo Kikuchi, Daisuke Kuga, Nobuhiro Hata, Masahiro Mizoguchi, Koji Iihara, Satoshi O. Suzuki, Toru Iwaki, Yuta Akamine, Akio Hiwatashi

    Neuroradiology   62 ( 7 )   815 - 823   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00234-020-02456-2

  • Vessel-selective 4D-MR angiography using super-selective pseudo-continuous arterial spin labeling may be a useful tool for assessing brain AVM hemodynamics Reviewed

    Osamu Togao, Makoto Obara, Michael Helle, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Yoshitomo Kikuchi, Ataru Nishimura, Koichi Arimura, Tatsuhiro Wada, Hiroo Murazaki, Koji Iihara, Marc Van Cauteren, Akio Hiwatashi

    European Radiology   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-020-07057-4

  • Differences between primary central nervous system lymphoma and glioblastoma topographic analysis using voxel-based morphometry Reviewed

    K. Yamashita, A. Hiwatashi, O. Togao, K. Kikuchi, D. Momosaka, N. Hata, Y. Akagi, S. O. Suzuki, T. Iwaki, K. Iihara, H. Honda

    Clinical Radiology   74 ( 10 )   816.e1 - 816.e8   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.crad.2019.06.017

  • Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma Reviewed

    K. Yamashita, R. Hatae, Hiwatashi Akio, Osamu Togao, kazufumi kikuchi, D. Momosaka, Y. Yamashita, Daisuke Kuga, Nobuhiro Hata, K. Yoshimoto, S. O. Suzuki, Toru Iwaki, Koji Iihara, Hiroshi Honda

    Diagnostic and Interventional Imaging   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diii.2019.02.010

  • Improved visualization of middle ear cholesteatoma with computed diffusion-weighted imaging Reviewed

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Yamato Shimomiya, Ryotaro Kamei, Daichi Momosaka, Nozomu Matsumoto, Kouji Kobayashi, Atsushi Takemura, Thomas Christian Kwee, Taro Takahara, Hiroshi Honda

    Magnetic Resonance in Medical Sciences   18 ( 3 )   233 - 237   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.tn.2018-0068

  • Simultaneous MR neurography and apparent T2 mapping in brachial plexus Evaluation of patients with chronic inflammatory demyelinating polyradiculoneuropathy Reviewed

    Hiwatashi Akio, Osamu Togao, Koji Yamashita, kazufumi kikuchi, Daichi Momosaka, Hiroshi Nakatake, Ryo Yamasaki, Hidenori Ogata, Masami Yoneyama, Jun-Ichi Kira, Hiroshi Honda

    Magnetic Resonance Imaging   55   112 - 117   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.mri.2018.09.025

  • Clinical efficacy of simplified intravoxel incoherent motion imaging using three b-values for differentiating high- and low-grade gliomas Reviewed

    Takuya Hino, Osamu Togao, Hiwatashi Akio, Koji Yamashita, kazufumi kikuchi, Daichi Momosaka, Hiroshi Honda

    PloS one   13 ( 12 )   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0209796

  • Ultrahigh-resolution CT scan of the temporal bone Reviewed

    Koji Yamashita, Hiwatashi Akio, Osamu Togao, kazufumi kikuchi, Nozomu Matsumoto, Daichi Momosaka, Hiroshi Nakatake, Yuki Sakai, Hiroshi Honda

    European Archives of Oto-Rhino-Laryngology   275 ( 11 )   2797 - 2803   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00405-018-5101-6

  • Arterial spin-labeling is useful for the diagnosis of residual or recurrent meningiomas Reviewed

    kazufumi kikuchi, Hiwatashi Akio, Osamu Togao, Koji Yamashita, Ryotaro Kamei, Koji Yoshimoto, Koji Iihara, Satoshi Suzuki, Toru Iwaki, Yuriko Suzuki, Hiroshi Honda

    European Radiology   28 ( 10 )   4334 - 4342   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-018-5404-4

  • A qualitative and quantitative correlation study of lumbar intervertebral disc degeneration using glycosaminoglycan chemical exchange saturation transfer, pfirrmann grade, and T1- Reviewed

    Osamu Togao, Hiwatashi Akio, T. Wada, Koji Yamashita, kazufumi kikuchi, C. Tokunaga, J. Keupp, M. Yoneyama, Hiroshi Honda

    American Journal of Neuroradiology   39 ( 7 )   1369 - 1375   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3174/ajnr.A5657

  • Diffusion-weighted magnetic resonance imaging of extraocular muscles in patients with Grave's ophthalmopathy using turbo field echo with diffusion-sensitized driven-equilibrium preparation Reviewed

    Hiwatashi Akio, Osamu Togao, Koji Yamashita, kazufumi kikuchi, D. Momosaka, Hiroshi Honda

    Diagnostic and Interventional Imaging   99 ( 7-8 )   457 - 463   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diii.2018.02.007

  • High Resolution Diffusion-Weighted Imaging for Solitary Orbital Tumors 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium (DSDE-TFE) Preparation Technique Reviewed

    Hiwatashi Akio, Osamu Togao, Koji Yamashita, kazufumi kikuchi, Hiroshi Yoshikawa, Makoto Obara, Hiroshi Honda

    Clinical Neuroradiology   28 ( 2 )   261 - 266   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00062-016-0556-6

  • Usefulness of perfusion- and diffusion-weighted imaging to differentiate between pilocytic astrocytomas and high-grade gliomas a multicenter study in Japan Reviewed

    kazufumi kikuchi, Hiwatashi Akio, Osamu Togao, Koji Yamashita, Ryotaro Kamei, Mika Kitajima, Masafumi Kanoto, Hiroto Takahashi, Yusuke Uchiyama, Masafumi Harada, Yuki Shinohara, Takashi Yoshiura, Yuki Wakata, Hiroshi Honda

    Neuroradiology   60 ( 4 )   391 - 401   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00234-018-1991-7

  • Acceleration-selective arterial spin-labeling MR angiography used to visualize distal cerebral arteries and collateral vessels in moyamoya disease Reviewed

    Osamu Togao, Hiwatashi Akio, Makoto Obara, Koji Yamashita, kazufumi kikuchi, Ryotaro Kamei, ataru nishimura, Koichi Arimura, Koji Yoshimoto, Koji Iihara, Marc Van Cauteren, Hiroshi Honda

    Radiology   286 ( 2 )   611 - 621   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1148/radiol.2017162279

  • Diffusivity of intraorbital lymphoma vs. inflammation comparison of single shot turbo spin echo and multishot echo planar imaging techniques Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Ryotaro Kamei, Hiroshi Yoshikawa, Atsushi Takemura, Hiroshi Honda

    European Radiology   28 ( 1 )   325 - 330   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-017-4995-5

  • Presaturation Power Adjusted Pulsed CEST A Method to Increase Independence of Target CEST Signals Reviewed

    Kazufumi Kikuchi, Keisuke Ishimatsu, Shanrong Zhang, Ivan E. Dimitrov, Hiroshi Honda, A. Dean Sherry, Masaya Takahashi

    Contrast Media and Molecular Imaging   2018   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2018/3141789

  • Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging Validation with histopathological vascular density in meningiomas Reviewed

    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Koji Yoshimoto, Daisuke Kuga, Masahiro Mizoguchi, Satoshi O. Suzuki, Toru Iwaki, Marc Van Cauteren, Koji Iihara, Hiroshi Honda

    British Journal of Radiology   91 ( 1085 )   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1259/bjr.20170912

  • Lumbar plexus in patients with chronic inflammatory demyelinating polyradiculoneuropathy Evaluation with simultaneous T2 mapping and neurography method with SHINKEI Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Hiroshi Nakatake, Ryo Yamasaki, Hidenori Ogata, Masami Yoneyama, Jun Ichi Kira, Hiroshi Honda

    British Journal of Radiology   91 ( 1092 )   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1259/bjr.20180501

  • Correlation between arterial spin-labeling perfusion and histopathological vascular density of pediatric intracranial tumors Reviewed

    Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi O. Suzuki, Toru Iwaki, Yuriko Suzuki, Hiroshi Honda

    Journal of Neuro-Oncology   135 ( 3 )   561 - 569   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11060-017-2604-8

  • Additive value of "otosclerosis-weighted" images for the CT diagnosis of fenestral otosclerosis Reviewed

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Masatoshi Kondo, Kazufumi Kikuchi, Takashi Inoguchi, Junki Maehara, Yusuke Kyuragi, Hiroshi Honda

    Acta Radiologica   58 ( 10 )   1215 - 1221   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0284185116687172

  • Lumbar plexus in patients with chronic inflammatory demyelinating polyneuropathy Evaluation with 3D nerve-sheath signal increased with inked rest-tissue rapid acquisition of relaxation enhancement imaging (3D SHINKEI) Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Ryotato Kamei, Daichi Momosaka, Hidenori Ogata, Ryo Yamasaki, Masami Yoneyama, Jun ichi Kira, Hiroshi Honda

    European Journal of Radiology   93   95 - 99   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejrad.2017.05.031

  • Amide proton transfer imaging of brain tumors using a self-corrected 3D fast spin-echo dixon method Comparison With separate B0 correction Reviewed

    Osamu Togao, Jochen Keupp, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Masami Yoneyama, Hiroshi Honda

    Magnetic Resonance in Medicine   77 ( 6 )   2272 - 2279   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mrm.26322

  • Cerebral blood flow laterality derived from arterial spin labeling as a biomarker for assessing the disease severity of parkinson's disease Reviewed

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Hiroo Yamaguchi, Yuriko Suzuki, Ryotaro Kamei, Ryo Yamasaki, Jun Ichi Kira, Hiroshi Honda

    Journal of Magnetic Resonance Imaging   45 ( 6 )   1821 - 1826   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jmri.25489

  • Evaluation of chronic inflammatory demyelinating polyneuropathy 3D nerve-sheath signal increased with inked rest-tissue rapid acquisition of relaxation enhancement imaging (3D SHINKEI) Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Hidenori Ogata, Ryo Yamasaki, Masami Yoneyama, Jun ichi Kira, Hiroshi Honda

    European Radiology   27 ( 2 )   447 - 453   2017.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-016-4406-3

  • Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging comparisons with diffusion- and perfusion-weighted imaging Reviewed

    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Jochen Keupp, Koji Yoshimoto, Daisuke Kuga, Masami Yoneyama, Satoshi O. Suzuki, Toru Iwaki, Masaya Takahashi, Koji Iihara, Hiroshi Honda

    European Radiology   27 ( 2 )   578 - 588   2017.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-016-4328-0

  • Primary phosphaturic mesenchymal tumour of the lumbar spine: utility of 68Ga-DOTATOC PET/CT findings

    Junki Maehara, Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Yoshihiro Matsumoto, Kunio Iura, Yoshinao Oda, Isao Ichino, Yuji Nakamoto, Hiroshi Honda

    BJR|case reports   2 ( 4 )   20150497 - 20150497   2016.11

     More details

    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1259/bjrcr.20150497

  • Recurrent Hemorrhagic Venous Infarctions Caused by Thrombosis of a Pontine Developmental Venous Anomaly and Protein S Mutation Reviewed

    Yuri Nakamura, Kei ichiro Takase, Takuya Matsushita, Satoshi Yoshimura, Ryo Yamasaki, Hiroyuki Murai, Kazufumi Kikuchi, Jun ichi Kira

    Journal of Stroke and Cerebrovascular Diseases   25 ( 11 )   e216 - e217   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2016.08.040

  • Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme Reviewed

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Yoshiyuki Kitamura, Masahiro Mizoguchi, Koji Yoshimoto, Daisuke Kuga, Satoshi O. Suzuki, Shingo Baba, Takuro Isoda, Toru Iwaki, Koji Iihara, Hiroshi Honda

    Journal of Magnetic Resonance Imaging   44 ( 5 )   1256 - 1261   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jmri.25261

  • Evaluation of glioblastomas and lymphomas with whole-brain CT perfusion Comparison between a delay-invariant singular-value decomposition algorithm and a Patlak plot Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi O. Suzuki, Takashi Yoshiura, Hiroshi Honda

    Journal of Neuroradiology   43 ( 4 )   266 - 272   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neurad.2016.01.147

  • Prognostic utility of computed tomography histogram analysis in patients with post-cardiac arrest syndrome Evaluation using an automated whole-brain extraction algorithm Reviewed

    Koji Yamashita, Akio Hiwatashi, Masatoshi Kondo, Osamu Togao, Kazufumi Kikuchi, Hiroshi Sugimori, Takashi Yoshiura, Hiroshi Honda

    Journal of Computer Assisted Tomography   40 ( 4 )   612 - 616   2016.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/RCT.0000000000000396

  • MR Imaging Findings of a Leiomyosarcoma of the Thoracic Spine A Case Report Reviewed

    K. Tahara, K. Yamashita, A. Hiwatashi, O. Togao, K. Kikuchi, M. Endo, H. Otsuka, Y. Oda, H. Honda

    Clinical Neuroradiology   26 ( 2 )   229 - 233   2016.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00062-015-0420-0

  • Amide proton transfer imaging of diffuse gliomas Effect of saturation pulse length in parallel transmission-based technique Reviewed

    Osamu Togao, Akio Hiwatashi, Jochen Keupp, Koji Yamashita, Kazufumi Kikuchi, Takashi Yoshiura, Masami Yoneyama, Marijn J. Kruiskamp, Koji Sagiyama, Masaya Takahashi, Hiroshi Honda

    PloS one   11 ( 5 )   2016.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0155925

  • 3D turbo field echo with diffusion-sensitized drivenequilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Hiroshi Yoshikawa, Makoto Obara, Hiroshi Honda

    British Journal of Radiology   89 ( 1067 )   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1259/bjr.20160074

  • MR imaging-based analysis of glioblastoma multiforme Estimation of IDH1 mutation status Reviewed

    K. Yamashita, Akio Hiwatashi, O. Togao, K. Kikuchi, R. Hatae, K. Yoshimoto, M. Mizoguchi, S. O. Suzuki, T. Yoshiura, H. Honda

    American Journal of Neuroradiology   37 ( 1 )   58 - 65   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3174/ajnr.A4491

  • Evaluation of diffusivity in pituitary adenoma 3D turbo field echo with diffusion-sensitized drivenequilibrium preparation Reviewed

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Makoto Obara, Takashi Yoshiura, Hiroshi Honda

    British Journal of Radiology   89 ( 1063 )   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1259/bjr.20150755

  • Differentiation of high-grade and low-grade diffuse gliomas by intravoxel incoherent motion MR imaging Reviewed

    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Masahiro Mizoguchi, Koji Yoshimoto, Satoshi O. Suzuki, Toru Iwaki, Makoto Obara, Marc Van Cauteren, Hiroshi Honda

    Neuro-Oncology   18 ( 1 )   132 - 141   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/neuonc/nov147

  • Arterial spin-labeling in central nervous system infection Reviewed

    Tomoyuki Noguchi, Yusuke Yakushiji, Masashi Nishihara, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Muneaki Matsuo, Shinya Azama, Hiroyuki Irie

    Magnetic Resonance in Medical Sciences   15 ( 4 )   386 - 394   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.mp.2015-0140

  • High-resolution three-dimensional diffusion-weighted MRI/CT image data fusion for cholesteatoma surgical planning a feasibility study Reviewed

    Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Nozomu Matsumoto, Makoto Obara, Takashi Yoshiura, Hiroshi Honda

    European Archives of Oto-Rhino-Laryngology   272 ( 12 )   3821 - 3824   2015.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00405-014-3467-7

  • Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors Reviewed

    Osamu Togao, Akio Hiwatashi, Jochen Keupp, Koji Yamashita, Kazufumi Kikuchi, Takashi Yoshiura, Yuriko Suzuki, Marijn J. Kruiskamp, Koji Sagiyama, Masaya Takahashi, Hiroshi Honda

    Journal of Magnetic Resonance Imaging   42 ( 5 )   1346 - 1353   2015.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jmri.24895

  • 3D MR Sequence Capable of Simultaneous Image Acquisitions with and without Blood Vessel Suppression Utility in Diagnosing Brain Metastases Reviewed

    Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Masami Yoneyama, Makoto Obara, Junji Kishimoto, Takashi Yoshiura, Hiroshi Honda

    European Radiology   25 ( 4 )   901 - 910   2015.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-014-3496-z

  • Minute Subsequent Fracture at Prophylactically Treated Adjacent Vertebra After Percutaneous Vertebroplasty Reviewed

    F. Kanzaki, A. Hiwatashi, T. Yoshiura, O. Togao, K. Yamashita, H. Kamano, K. Kikuchi, H. Honda

    Clinical Neuroradiology   24 ( 4 )   381 - 383   2014.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00062-013-0254-6

  • Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS A case report Reviewed

    Ryuji Uehara, Koji Yamashita, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Jun Yokoyama, Dai Matsuse, Takashi Yoshiura, Hiroshi Honda

    Brain and Behavior   4 ( 6 )   798 - 800   2014.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/brb3.282

  • Volume isotropic simultaneous interleaved black- and bright-blood imaging A novel sequence for contrast-enhanced screening of brain metastasis Reviewed

    Masami Yoneyama, Makoto Obara, Taro Takahara, Kazufumi Kikuchi, Masanobu Nakamura, Satoshi Tatsuno, Seishi Sawano, Tetsuo Ogino, Osamu Togao, Takashi Yoshiura

    Magnetic Resonance in Medical Sciences   13 ( 4 )   277 - 284   2014.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.2013-0065

  • Balloon test occlusion of internal carotid artery: Angiographic findings predictive of results. International journal

    Kazufumi Kikuchi, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Hiroshi Honda

    World journal of radiology   6 ( 8 )   619 - 24   2014.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4329/wjr.v6.i8.619

  • Amide proton transfer imaging of adult diffuse gliomas Correlation with histopathological grades Reviewed

    Osamu Togao, Takashi Yoshiura, Jochen Keupp, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Yuriko Suzuki, Satoshi O. Suzuki, Toru Iwaki, Nobuhiro Hata, Masahiro Mizoguchi, Koji Yoshimoto, Koji Sagiyama, Masaya Takahashi, Hiroshi Honda

    Neuro-Oncology   16 ( 3 )   441 - 448   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/neuonc/not158

  • Diffusivity of intraorbital lymphoma vs. IgG4-related DISEASE 3D turbo field echo with diffusion-sensitised driven-equilibrium preparation technique Reviewed

    Akio Hiwatashi, Takashi Yoshiura, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Yoko Fujita, Hiroshi Yoshikawa, Takaomi Koga, Makoto Obara, Hiroshi Honda

    European Radiology   24 ( 3 )   581 - 586   2014.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00330-013-3058-9

  • Additional MR contrast dosage for radiologists' diagnostic performance in detecting brain metastases A systematic observer study at 3 T Reviewed

    Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Takashi Yoshiura, Hiroshi Honda

    Japanese Journal of Radiology   537 - 544   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11604-014-0342-9

  • Vertebroplasty Up to date Reviewed

    Hiwatashi Akio, Osamu Togao, Koji Yamashita, kazufumi kikuchi, Hiroshi Honda

    Japanese Journal of Clinical Radiology   59 ( 4 )   533 - 539   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • The radiological diagnosis of fenestral otosclerosis the utility of histogram analysis using multidetector row CT Reviewed

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi, Takashi Inoguchi, Seiji Kumazawa, Hiroshi Honda

    European Archives of Oto-Rhino-Laryngology   271 ( 12 )   3277 - 3282   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00405-014-2933-6

  • Evaluation of diffusivity in the anterior lobe of the pituitary gland 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation Reviewed

    Akio Hiwatashi, T. Yoshiura, O. Togao, K. Yamashita, K. Kikuchi, K. Kobayashi, M. Ohga, S. Sonoda, H. Honda, M. Obara

    American Journal of Neuroradiology   35 ( 1 )   95 - 98   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3174/ajnr.A3620

  • High-resolution three-dimensional diffusion-weighted imaging of middle ear cholesteatoma at 3.0 T MRI Usefulness of 3D turbo field-echo with diffusion-sensitized driven-equilibrium preparation (TFE-DSDE) compared to single-shot echo-planar imaging Reviewed

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Makoto Obara, Osamu Togao, Nozomu Matsumoto, Kazufumi Kikuchi, Hiroshi Honda

    European Journal of Radiology   82 ( 9 )   e471 - e475   2013.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejrad.2013.04.018

  • Resolution of epidural hematoma related to osteoporotic fracture after percutaneous vertebroplasty. International journal

    Hidenari Hirata, Akio Hiwatashi, Takashi Yoshiura, Osamu Togao, Koji Yamashita, Hironori Kamano, Kazufumi Kikuchi, Hiroshi Honda

    World journal of radiology   5 ( 8 )   325 - 7   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4329/wjr.v5.i8.325

  • Differentiating primary CNS lymphoma from glioblastoma multiforme Assessment using arterial spin labeling, diffusion-weighted imaging, and 18F-fluorodeoxyglucose positron emission tomography Reviewed

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Koji Yoshimoto, Satoshi O. Suzuki, Koichiro Abe, Kazufumi Kikuchi, Yasuhiro Maruoka, Masahiro Mizoguchi, Toru Iwaki, Hiroshi Honda

    Neuroradiology   55 ( 2 )   135 - 143   2013.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00234-012-1089-6

  • Arterial spin labeling of hemangioblastoma Differentiation from metastatic brain tumors based on quantitative blood flow measurement Reviewed

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Koji Yoshimoto, Satoshi O. Suzuki, Kazufumi Kikuchi, Masahiro Mizoguchi, Toru Iwaki, Hiroshi Honda

    Neuroradiology   54 ( 8 )   809 - 813   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00234-011-0977-5

  • Unusual presentation of an esophageal foreign body granuloma caused by a fish bone Usefulness of multidetector computed tomography Reviewed

    Kazufumi Kikuchi, Daisuke Tsurumaru, Kiyohisa Hiraka, Masahiro Komori, Nobuhiro Fujita, Hiroshi Honda

    Japanese Journal of Radiology   29 ( 1 )   63 - 66   2011.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11604-010-0495-0

  • Laminin peptide YIGSR and its receptor regulate sensory axonal response to the chemoattractive guidance cue in the chick embryo Reviewed

    Tomoyuki Masuda, Chie Sakuma, Kenta Kobayashi, Kazufumi Kikuchi, Emi Soda, Takashi Shiga, Kazuto Kobayashi, Hiroyuki Yaginuma

    Journal of Neuroscience Research   87 ( 2 )   353 - 359   2009.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jnr.21868

▼display all

Presentations

▼display all

MISC

  • Refresher Course 脳神経関連で役立つMRI撮像技術 arterial spin labeling(ASL)

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   44 ( 3 )   361 - 373   2024.2   ISSN:0285-0524

     More details

    Language:Japanese   Publisher:(株)Gakken  

    本稿では,ASLの原理と臨床応用について概説する.ASLは,動脈血を内因性トレーサーとして使用して脳灌流を画像化する非侵襲的手法であり,脳虚血,脳腫瘍,急性脳炎,脳症など様々な疾患の診断に有用である.また,脳血流量などの脳循環指標の定量化を行うことも可能である他,MRA技術として用いることもできる.

  • Cortical high-flow signの有用性:Oligodendroglioma検出能におけるASL法とDSC法の比較

    山下孝二, 栂尾理, 菊地一史, 空閑太亮, 吉本幸司, 石神康生

    日本神経放射線学会プログラム・抄録集   53rd   2024

  • 【臨床脳腫瘍学-最新の診断・治療と病態-】脳腫瘍の検査・診断 画像診断各論 MRI 代謝画像(CEST)

    栂尾 理, 山下 孝二, 菊地 一史

    日本臨床   81 ( 増刊9 臨床脳腫瘍学 )   168 - 173   2023.12   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

  • 【Neuroradiology Frontier 2024 中枢神経の画像診断最前線 最先端技術で広がる臨床の可能性】脳腫瘍における画像診断技術と臨床の最前線 脳腫瘍における画像診断の最前線 装置,撮像法など技術を中心に

    山下 孝二, 栂尾 理, 菊地 一史, 石神 康生

    INNERVISION   39 ( 1 )   37 - 39   2023.12   ISSN:0913-8919

     More details

    Language:Japanese   Publisher:(株)インナービジョン  

    2021年に,WHO中枢神経系腫瘍分類第5版が出版された。最大の特徴として,組織学的所見と比べた分子遺伝学的情報の診断への寄与度が,2016年出版の改訂第4版以上に顕著となっており,腫瘍型分類にも反映されている。これは,主に分子遺伝学的所見による分類が,生命予後や治療反応性と相関することがエビデンスとして示されたことによる。画像診断学は病理組織所見との対比により発展してきたが,今回の腫瘍型分類改訂に伴い,従来の方法では術前の腫瘍型推定が困難な症例にも直面している。それでも,WHO中枢神経系腫瘍分類第5版では,発生部位,組織学的グレーディングおよび分子遺伝学的所見の組み合わせによる統合診断・層別化が重視されており,信号パターン以外にも,局在や広がりが非侵襲的に評価できる画像情報が術前診断に果たす役割は大きい。本稿では,腫瘍の縦緩和時間(T1値),横緩和時間(T2値),プロトン密度(PD)を同時取得する手法として,synthetic MRIの二次元Quantification of Relaxation Times and Proton Density by Multi-Echo acquisition of a saturation-recovery using Turbo spin-Echo Read-out(2D-QRAPMASTER)および3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse(3D-QALAS)法について概説し,pseudo-3D DWI using echo planar imaging with compressed SENSE(EPICS-DWI)を用いたapparent diffusion coefficient(ADC)定量法,最後に,MR spectroscopy(MRS)を用いた分子遺伝学的所見検出の可能性について紹介する。(著者抄録)

  • 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】Diffuse hemispheric glioma, H3 G34-mutant

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生

    画像診断   43 ( 10 )   988 - 992   2023.8   ISSN:0285-0524

     More details

    Language:Japanese   Publisher:(株)Gakken  

  • 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】High-grade astrocytoma with piloid features

    栂尾 理, 山下 孝二, 菊地 一史, 石神 康生, 黒川 遼, 森谷 聡男

    画像診断   43 ( 10 )   998 - 1000   2023.8   ISSN:0285-0524

     More details

    Language:Japanese   Publisher:(株)Gakken  

  • 増強効果の乏しいIDH-wildtype diffuse astrocytic gliomaにおけるTERT遺伝子変異の予測

    山下孝二, 栂尾理, 菊地一史, 石神康生, 空閑太亮, 吉本幸司

    日本神経放射線学会プログラム・抄録集   52nd   2023

  • 【ビギナーのための頭部画像診断-Q&Aアプローチ-2023】解剖・正常変異 部位別の鑑別診断 硬膜外腔,硬膜下腔,くも膜下腔はそれぞれMRIでどのように描出されますか?

    菊地 一史

    画像診断   43 ( 1 )   48 - 49   2022.12   ISSN:0285-0524

     More details

    Language:Japanese   Publisher:(株)Gakken  

  • 【Step up MRI 2022 MRI研究の最新動向&領域別MRI技術の臨床応用とトピックス】MRI研究の最新動向 Arterial spin labeling MRI技術の最新動向

    栂尾 理, 山下 孝二, 菊地 一史, 小原 真, 石神 康生

    INNERVISION   37 ( 9 )   4 - 8   2022.8   ISSN:0913-8919

     More details

    Language:Japanese   Publisher:(株)インナービジョン  

    arterial spin labeling(以下、ASL)は動脈血中のプロトンのスピンをラベルし、それを内因性トレーサーとして画像化に利用する非侵襲的手法である。近年、臨床現場では、pseudo-continuous ASL(以下、pCASL)の導入により、ASLを用いた脳灌流画像の使用が普及しつつある。臨床で用いられるASLは、通常1つのlabel duration(以下、LD)と1つのpost-labeling delay(以下、PLD)の組み合わせによる1時相での撮像であるが、ラベルされた血液がラベル面から脳組織に到達するまでの時間(arterial transit time:ATT)が長く、ラベルされた血液が到達していない場合には、正しく脳血流量(cerebral blood flow:CBF)を評価することができない。最近では、多時相撮像を行うことでATTの影響を考慮したCBFの定量化が行われるようになってきている。また、ASLは脳灌流画像のみでなく、MR angiography(以下、MRA)にも応用することができる。臨床で用いられるtime of flight(以下、TOF)-MRAは撮像スラブへのinflow効果に依存しているため、上方向以外の血流、乱流、遅い血流などの描出は不良であることや、時間情報を持っていないという欠点がある。ASLによる4D-MRAは、TOF-MRAの弱点を克服しつつ時間情報を有する画像法である。さらに、血管選択的画像も取得することができ、選択的digital subtraction angiography(以下、DSA)の代替となるような画像も得られる。本稿では、多時相ASL灌流画像とASLを用いた4D-MRAの開発の最近の動向と、それらの臨床的有用性を概説する。(著者抄録)

  • 【免疫性神経疾患(第2版)-基礎・臨床の最新知見-】診療に役立つ免疫性末梢神経疾患の画像検査とその解釈

    樋渡 昭雄, 栂尾 理, 菊地 一史

    日本臨床   80 ( 増刊5 免疫性神経疾患 )   78 - 82   2022.5   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

  • 【最新臨床脳卒中学(第2版)下-最新の診断と治療-】脳梗塞総論 脳梗塞の画像診断

    栂尾 理, 樋渡 昭雄, 菊地 一史, 石神 康生

    日本臨床   80 ( 増刊2 最新臨床脳卒中学(下) )   13 - 21   2022.2   ISSN:0047-1852

     More details

    Language:Japanese   Publisher:(株)日本臨床社  

  • 皮質下白質の拡散能に高度な左右差を認めた皮質基底核変性症の1例

    菊地 一史, 栂尾 理, 吉浦 敬, 樋渡 昭雄, 山下 孝二, 本田 浩, 大八木 保政, 吉良 潤一

    2013.2

     More details

    Language:Japanese  

▼display all

Professional Memberships

  • Japanese Society of Nuclear Medicine

  • Japanese Society of Magnetic Resonance in Medicine JSMRM

  • Japanese Society of Neuroradiology JSNR

  • Japanese Society of Pediatric Radiology JSPR

  • Japanese Society of Interventional Radiology JSIR

  • ISMRM International Society of Magnetic Resonance in Medicine

  • RSNA Radiological Society of North America

  • ASNR American Society of Neuroradiology

  • Japan Radiological Society

▼display all

Committee Memberships

  • 九州大学病院   保険診療適正化推進委員会委員  

    2024.4 - 2025.3   

      More details

  • 九州大学病院   外来診療部門運営委員会委員  

    2024.4 - 2025.3   

      More details

  • 九州大学病院 放射線科   外来医長  

    2024.4 - 2025.3   

      More details

Academic Activities

  • 不明

    なし  2021.8

     More details

    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2020

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

Research Projects

  • Variable-TR法を用いた4D-ASLによる脳循環パラメータの定量的評価法の開発

    Grant number:23K07137  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    栂尾 理, 菊地 一史, 山下 孝二

      More details

    Grant type:Scientific research funding

    本研究の目的は新たなスキームを用いた4D-ASLを開発し、それによる脳循環パラメータの定量的測定法を確立することである。
    1)ファントム実験による撮像パラメータの最適化を行う。開発したパルスシークエンスの定量性を検討するために複数のラベル時間とpost-labeling delayの組み合わせを用いて撮像を行い、それらの定量性を検討し、最適な条件を決定する。
    2)variable-TR法とtime-encoded法のハイブリッド法を健常者にて撮像し、その定量性を評価する。
    3)脳主幹動脈閉塞性疾患の患者においてハイブリッド撮像を行い、脳血流SPECTと比較し定量性を評価する。

    CiNii Research

  • 深層学習と血管抑制・非抑制画像を利用した新たな転移性脳腫瘍診断法の確立

    Grant number:21K07645  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    樋渡 昭雄, 栂尾 理, 菊地 一史, 石神 康生

      More details

    Grant type:Scientific research funding

    脳転移診断には一般に造影後3DT1WIが用いられるが、増強された血管と微小転移の区別が困難な場合がある。VISIBLE (Volume Isotropic Simultaneous Interleaved Bright- and bLack-blood Examination)法は血管信号抑制画像と非抑制画像を同時取得し、高感度、低偽陽性率で脳転移を診断可能であるが、従来法では撮像に5分程度必要である。そこで本研究はVISIBLE法を応用した新たな短時間の撮像法の開発、脳転移症例を深層学習させたAIシステムによる脳転移の自動検出法、および最適な治療法選択法の開発を行う

    CiNii Research

  • 新たなASLアプローチを用いたMRAおよび灌流画像の開発と臨床応用

    Grant number:20K08111  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    栂尾 理, 菊地 一史, 樋渡 昭雄

      More details

    Grant type:Scientific research funding

    本研究ではこれらの新しいASLアプローチを用いたMRAおよび灌流画像の開発とその臨床応用を目指す。まずAccASLによる脳灌流画像の定量性の検討を行う。SPECTを基準とし定量性を比較する。次に4D-PACKの臨床的有用性を検討する。脳動静脈短絡性疾患の患者において4D-PACKを撮像し、各コンポーネントの描出能についてContrast-to-noise Ratioの測定を行うことで検討する。最後に4D-S-PACKの撮像条件の最適化と後処理法の開発を行う。超選択的ラベルの位置やサイズの最適化、血管選択性の確認を行う。人工知能による自動ラベル位置決定アルゴリズムの開発も行う。

    CiNii Research

  • 小児脳腫瘍のMultiparametric解析によるより高度な診断法の確立

    Grant number:19K21273  2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Grant type:Scientific research funding

Class subject

  • なし

    2021.4 - 2021.9   First semester

FD Participation

  • 2021.8   Title:なし

Outline of Social Contribution and International Cooperation activities

  • 九州大学病院において放射線診断業務に従事
    新たな画像診断法の確立のための研究および成果の報告

Social Activities

  • 不明

    なし  2021.8

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

  • なし

    2021.8

     More details

    Audience: Infants, Schoolchildren, Junior students, High school students

  • なし

    2021

     More details

    なし

Media Coverage

  • なし

    2021.8

     More details

    なし

Educational Activities for Highly-Specialized Professionals in Other Countries

  • 2021.8   なし

    Main countries of student/trainee affiliation:Japan

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Radiology

Clinician qualification

  • Specialist

    Japan Radiological Society(JRS)

  • Preceptor

    Japan Radiological Society(JRS)

Year of medical license acquisition

  • 2006

Notable Clinical Activities

  • 画像誘導下の低侵襲治療 経皮的生検術、経皮的椎体形成術