Updated on 2024/12/03

Information

 

写真a

 
ISODA TAKURO
 
Organization
Kyushu University Hospital Radiology Center Lecturer
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Title
Lecturer
Tel
0926425695
Profile
(研究) ①放射性ヨウ素内用療法の効果予測、副作用低減 (教育) [医学部生] 医学部2年生の医工学入門 医学部3年生 系統講義「神経」核医学 医学部4年生 系統医学II 放射線医学 核医学 医学部4-5年生の核医学実習:核医学検査の基礎、画像評価 医学部5-6年生の核医学実習:読影実習にて核医学検査の原理、正常像、読影法等を指導。 [臨床研修医] 核医学検査・治療に関して原理・方法、適応、読影について指導 放射線科病棟業務の指導 (診療) 九州大学病院にて放射線診断専門医、核医学専門医として核医学検査、アイソトープ治療に携わる。 放射線科外来にて甲状腺癌患者および甲状腺機能亢進症患者、前立腺癌骨転移の診療(アイソトープ治療関連) 放射線科病棟においては放射性ヨウ素内用療法を受ける甲状腺癌患者の診療 アイソトープセンターおよび核医学・PETセンターの運営に携わる。
External link

Degree

  • ,

Research History

  • 福岡市立こども病院 福岡県済生会福岡総合病院

    福岡市立こども病院 福岡県済生会福岡総合病院

  • 札幌医科大学附属病院

Research Interests・Research Keywords

  • Research theme:Analysis of non-pathological FDG accumulaiton

    Keyword:FDG, physiological uptake

    Research period: 2022.1 - 2024.1

  • Research theme:Evaluation of inflammatory lesions with FDG

    Keyword:FDG, inflammatory lesion

    Research period: 2018.1 - 2024.12

  • Research theme:Analysis of salivary gland disorder caused by radioiodine therapy for thyroid cancer

    Keyword:salivary gland disorder, radioiodine therapy, thyroid cancer

    Research period: 2014.7 - 2020.12

  • Research theme:Prediction of effectiveness of radioiodine therapy for thyroid cancer

    Keyword:Thyroid cancer, radioiodine therapy, treatment effect prediction

    Research period: 2014.6 - 2022.6

Awards

  • Poster Award Bronze

    2018.6   Society of Nuclear Medicine and Molecular Imaging Annual Meeting   FDG-PET of drive line infection and non-pathological uptake in or around a ventricular assist device

Papers

  • Different Impact of Immunosuppressive Therapy on Cardiac Outcomes in Systemic Versus Isolated Cardiac Sarcoidosis

    Masunaga Tomoka, Hashimoto Toru, Fujino Takeo, Ohtani Kisho, Ishikawa Yusuke, Yoshitake Tomoaki, Shinohara Keisuke, Matsushima Shouji, Ide Tomomi, Yamasaki Yuzo, Isoda Takuro, Baba Shingo, Ishigami Kousei, Tsutsui Hiroyuki, Kinugawa Shintaro

    International Heart Journal   65 ( 5 )   856 - 865   2024.9   ISSN:13492365 eISSN:13493299

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    <p>Isolated cardiac sarcoidosis (iCS) is increasingly recognized; however, its prognosis and the efficacy of immunosuppressive therapy remain undetermined. We aimed to compare the prognosis of iCS and systemic sarcoidosis including cardiac involvement (sCS) under immunosuppressive therapy.</p><p>We retrospectively reviewed the clinical data of 42 patients with sCS and 30 patients with iCS diagnosed at Kyushu University Hospital from 2004 through 2022. We compared the characteristics and the rate of adverse cardiac events including cardiac death, fatal ventricular tachyarrhythmia, and heart failure hospitalization between the 2 groups. The median follow-up time was 1535 [interquartile range, 630-2555] days, without a significant difference between the groups. There were no significant differences in gender, NYHA class, or left ventricular ejection fraction. Immunosuppressive agents were administered in 86% of sCS and in 73% of iCS patients (<i>P</i> = 0.191). When analyzed only with patients receiving immunosuppressive therapy (sCS, <i>n</i> = 36; iCS, <i>n</i> = 21), the cardiac event-free survival was significantly lower in iCS than sCS (37% versus 79%, <i>P</i> = 0.002). Myocardial LGE content at the initial diagnosis was comparable in both groups. The disease activity was serially evaluated in 26 sCS and 16 iCS patients by quantitative measures of FDG-PET including cardiac metabolic volume and total lesion glycolysis, representing 3-dimensional distribution and intensity of inflammation in the entire heart. Although iCS patients had lower baseline disease activity than sCS patients, immunosuppressive therapy did not attenuate disease activity in iCS in contrast to sCS.</p><p>iCS showed a poorer response to immunosuppressive therapy and a worse cardiac prognosis compared to sCS despite lower baseline disease activity.</p>

    DOI: 10.1536/ihj.24-166

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  • Right Ventricular to Pulmonary Artery Uncoupling Is Associated With Impaired Exercise Capacity in Patients With Transthyretin Cardiac Amyloidosis

    Hashimoto Toru, Ikuta Kei, Yamamoto Shoei, Yoshitake Tomoaki, Suenaga Tomoyasu, Nakashima Shunsuke, Kai Takashi, Misumi Kayo, Fujino Takeo, Shinohara Keisuke, Matsushima Shouji, Atsumi Rina, Isoda Takuro, Kinugawa Shintaro, Abe Kohtaro

    Circulation Journal   advpub ( 0 )   2024.9   ISSN:13469843 eISSN:13474820

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    Language:English   Publisher:The Japanese Circulation Society  

    <p><b><i>Background:</i></b> Exercise capacity is related to mortality and morbidity in heart failure (HF) patients. Determinants of exercise capacity in transthyretin cardiac amyloidosis (ATTR-CA) have not been established.</p><p><b><i>Methods and Results:</i></b> This single-center study retrospectively evaluated ATTR-CA patients and patients with non-amyloidosis HF with preserved/mildly reduced ejection fraction (HFpEF/HFmrEF) (n=32 and n=51, respectively). In the ATTR-CA group, the median age was 75.5 years (interquartile range [IQR] 71.3–78.8 years), 90.6% were male, and the median left ventricular (LV) ejection fraction was 53.5% (IQR 41.4–65.6%). Cardiopulmonary exercise tests revealed a median peak oxygen consumption and anaerobic threshold of 15.9 (IQR 11.6–17.4) and 10.6 (IQR 8.5–12.0] mL/min/kg, respectively, and ventilatory efficiency (minute ventilation/carbon dioxide production [V̇<sub>E</sub>/V̇<sub>CO2</sub>] slope) of 35.5 (IQR 32.0–42.5). Among exercise variables, V̇<sub>E</sub>/V̇<sub>CO2</sub>slope has the greatest prognostic value. Univariate analysis revealed a significant correlation between V̇<sub>E</sub>/V̇<sub>CO2</sub>slope and age, LV global longitudinal strain, tricuspid annular plain systolic excursion/pulmonary arterial systolic pressure (TAPSE/PASP) ratio, and mixed venous oxygen saturation. In multivariate analyses, the TAPSE/PASP ratio was an independent predictor of V̇<sub>E</sub>/V̇<sub>CO2</sub>slope (95% confidence interval −44.5, −10.8; P=0.0067). In non-amyloidosis HFpEF/HFmrEF patients, the TAPSE/PASP ratio was not independently correlated with V̇<sub>E</sub>/V̇<sub>CO2</sub>slope.</p><p><b><i>Conclusions:</i></b> Right ventricular–pulmonary artery coupling estimated by the TAPSE/PASP ratio determines exercise capacity in ATTR-CA patients. This highlights the importance of early therapeutic intervention against underappreciated right ventricular dysfunction associated with ATTR-CA.</p>

    DOI: 10.1253/circj.cj-24-0402

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  • Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function

    Kikuchi, K; Togao, O; Yamashita, K; Isoda, T; Nishimura, A; Arimura, K; Nakamizo, A; Yoshimoto, K; Ishigami, K

    SCIENTIFIC REPORTS   14 ( 1 )   5468   2024.3   ISSN:2045-2322

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    Moyamoya disease (MMD) is characterized by progressive arterial occlusion, causing chronic hemodynamic impairment, which can reduce brain volume. A novel quantitative technique, synthetic magnetic resonance imaging (SyMRI), can evaluate brain volume. This study aimed to investigate whether brain volume measured with SyMRI correlated with cerebral blood flow (CBF) and brain function in adult MMD. In this retrospective study, 18 adult patients with MMD were included. CBF was measured using iodine-123-N-isopropyl-p-iodoamphetamine single photon emission computed tomography. Cerebrovascular reactivity (CVR) to acetazolamide challenge was also evaluated. Brain function was measured using the Wechsler Adult Intelligence Scales (WAIS)-III/IV and the WAIS-R tests. Gray matter (GM), white matter, and myelin-correlated volumes were evaluated in six areas. Resting CBF was positively correlated with GM fractions in the right anterior cerebral arterial and right middle cerebral arterial (MCA) territories. CVR was positively correlated with GM fraction in the right posterior cerebral arterial (PCA) territory. Full-Scale Intelligence Quotient and Verbal Comprehension Index scores were marginally positively correlated with GM fractions in the left PCA territory. Processing Speed Index score was marginally positively correlated with GM fraction in the right MCA territory. The SyMRI-measured territorial GM fraction correlated with CBF and brain function in patients with MMD.

    DOI: 10.1038/s41598-024-56210-2

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  • Dynamic chest radiography for pulmonary vascular diseases: clinical applications and correlation with other imaging modalities

    Yamasaki Yuzo, Kamitani Takeshi, Sagiyama Koji, Hino Takuya, Kisanuki Megumi, Tabata Kosuke, Isoda Takuro, Kitamura Yoshiyuki, Abe Kohtaro, Hosokawa Kazuya, Toyomura Daisuke, Moriyama Shohei, Kawakubo Masateru, Yabuuchi Hidetake, Ishigami Kousei

    Japanese Journal of Radiology   42 ( 2 )   126 - 144   2023.8   ISSN:18671071 eISSN:1867108X

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    Dynamic chest radiography (DCR) is a novel functional radiographic imaging technique that can be used to visualize pulmonary perfusion without using contrast media. Although it has many advantages and clinical utility, most radiologists are unfamiliar with this technique because of its novelty. This review aims to (1) explain the basic principles of lung perfusion assessment using DCR, (2) discuss the advantages of DCR over other imaging modalities, and (3) review multiple specific clinical applications of DCR for pulmonary vascular diseases and compare them with other imaging modalities.

    DOI: 10.1007/s11604-023-01483-2

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  • Predicting value of 11C-methionine PET/CT in gliomas based on the 2021 WHO classification.

    Kitamura, Y; Baba, S; Isoda, T; Maruoka, Y; Togao, O; Kuga, D; Sasaki, M; Ishigami, K

    JOURNAL OF NUCLEAR MEDICINE   64   2023.6   ISSN:0161-5505 eISSN:1535-5667

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  • Impacts of Clinical and Imaging Factors on the Outcome of Radioiodine Therapy for the Patients with Bone Metastasis from Thyroid Cancer

    Isoda, T; Baba, S; Maruoka, Y; Kitamura, Y; Sasaki, M; Ishigami, K

    JOURNAL OF NUCLEAR MEDICINE   64   2023.6   ISSN:0161-5505 eISSN:1535-5667

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  • Efficacy of Dynamic Chest Radiography for Chronic Thromboembolic Pulmonary Hypertension

    Yamasaki, Y; Abe, K; Kamitani, T; Hosokawa, K; Hida, T; Sagiyama, K; Matsuura, Y; Baba, S; Isoda, T; Maruoka, Y; Kitamura, Y; Moriyama, S; Yoshikawa, H; Fukumoto, T; Yabuuchi, H; Ishigami, K

    RADIOLOGY   306 ( 3 )   e220908   2023.3   ISSN:0033-8419

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    Language:English   Publisher:Radiology  

    Background: While current guidelines require lung ventilation-perfusion (V/Q) scanning as the first step to diagnose chronic pulmonary embolism in pulmonary hypertension (PH), its use may be limited by low availability and/or exposure to ionizing radiation. Purpose: To compare the performance of dynamic chest radiography (DCR) and lung V/Q scanning for detection of chronic thromboembolic PH (CTEPH). Materials and Methods: Patients with PH who underwent DCR and V/Q scanning in the supine position from December 2019 to July 2021 were retrospectively screened. The diagnosis of CTEPH was confirmed with right heart catheterization and invasive pulmonary angiography. Observer tests were conducted to evaluate the diagnostic accuracy of DCR and V/Q scanning. The lungs were divided into six areas (upper, middle, and lower for both) in the anteroposterior image, and the number of lung areas with thromboembolic perfusion defects was scored. Diagnostic performance was compared between DCR and V/Q scanning using the area under the receiver operating characteristic curve. Agreement between the interpretation of DCR and that of V/Q scanning was assessed using the Cohen kappa coefficient and percent agreement. Results: A total of 50 patients with PH were analyzed: 29 with CTEPH (mean age, 64 years ± 15 [SD]; 19 women) and 21 without CTEPH (mean age, 61 years ± 22; 14 women). The sensitivity, specificity, and accuracy of DCR were 97%, 86%, and 92%, respectively, and those of V/Q scanning were 100%, 86%, and 94%, respectively. Areas under the receiver operating characteristic curve for DCR and V/Q scanning were 0.92 (95% CI: 0.79, 0.97) and 0.93 (95% CI: 0.78, 0.98). Agreement between the consensus interpretation of DCR and that of V/Q scanning was substantial (κ = 0.79 [95% CI: 0.61, 0.96], percent agreement = 0.9 [95% CI: 0.79, 0.95]). Conclusion: Dynamic chest radiography had similar efficacy to ventilation-perfusion scanning in the detection of chronic thromboembolic pulmonary hypertension.

    DOI: 10.1148/radiol.220908

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  • Clinical Implications of FDG-PET in Pancreatic Ductal Adenocarcinoma Patients Treated with Neoadjuvant Therapy

    Ikenaga, N; Nakata, K; Hayashi, M; Nakamura, S; Abe, T; Ideno, N; Murakami, M; Fujimori, N; Fujita, N; Isoda, T; Baba, S; Ishigami, K; Oda, Y; Nakamura, M

    JOURNAL OF GASTROINTESTINAL SURGERY   27 ( 2 )   337 - 346   2023.2   ISSN:1091-255X eISSN:1873-4626

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    Purpose: To evaluate the clinical significance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with pancreatic ductal adenocarcinoma who underwent neoadjuvant therapy. Methods: Among 285 consecutive patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma between 2015 and 2021, 86 who underwent preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography after completion of neoadjuvant treatment were reviewed. Among preoperative factors, including post-treatment maximum standardized uptake value, predictors of early recurrence and poor prognosis were identified using multivariate analysis for decision making in surgery. Results: Nineteen (22%) patients with pancreatic ductal adenocarcinoma demonstrated high maximum standardized uptake (≥ 4.5). High post-treatment maximum standardized uptake (≥ 4.5) predicted early recurrence within 6 months after surgery and correlated with shorter recurrence-free survival. Elevated post-treatment CA19-9 level (> 37 U/ml) and maximum standardized uptake ≥ 4.5 were independent prognostic factors. Post-treatment, a high maximum standardized uptake value indicated a poorer prognosis than a low maximum standardized uptake value in both patients with elevated CA19-9 and normal CA19-9 levels. The median overall survival in patients with elevated post-treatment CA19-9 and high maximum standardized uptake was only 17 months; 67% experienced early recurrence. Dynamic changes in maximum standardized uptake during neoadjuvant therapy were correlated with pathological response to neoadjuvant therapy, but not with radiological response or change in CA19-9 level. Conclusions: Post-treatment assessment using maximum standardized uptake value is useful for stratifying patients with pancreatic ductal adenocarcinoma who will benefit from surgery. Instead of subsequent curative resection, additional neoadjuvant therapy should be considered in patients with a persistently high maximum standardized uptake value.

    DOI: 10.1007/s11605-023-05591-2

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  • Utility of FDG PET at the Initial Radioiodine Therapy in Differentiated Thyroid Cancer

    Matsuo, M; Baba, S; Hashimoto, K; Isoda, T; Kitamura, Y; Kogo, R; Jiromaru, R; Hongo, T; Manako, T; Nakagawa, T

    ANTICANCER RESEARCH   43 ( 1 )   183 - 190   2023.1   ISSN:0250-7005 eISSN:1791-7530

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    Background/Aim: Differentiated thyroid cancer (DTC) has a good prognosis, except in the case of patients with radioiodine therapy (RIT)-refractory cancer. However, since DTC is essentially a slowly progressing cancer, it is usually judged to be a DTC with a poor prognosis after multiple RITs and yearly follow-up with echo, computed tomography (CT), and serum thyroglobulin values. This study investigated whether fluorodeoxyglucose-positron emission tomography/CT (FDG PET/CT) combined with initial RIT could identify early-stage patients with poor prognosis. Patients and Methods: We evaluated 100 patients with high-risk DTC who underwent total thyroidectomy and received RIT at our institution. We analyzed the clinical outcomes of patients and 18F-FDG accumulation using univariate and multivariate Cox proportional hazards regression models. Results: The 10-year overall survival (OS) was 87.9%, with no significant difference in OS between 18F-FDG accumulation at pre-total or near-total thyroidectomy (NTT) (p=0.180) and 131I accumulation at initial RIT (p=0.577). However, 18F-FDG positive patients had a significantly worse prognosis than negative patients (p=0.005) at initial RIT. Conclusion: 18F-FDG PET/CT plays an important role in both the diagnosis and prognostic prediction of RIT refractory disease in DTC patients. 18F-FDG PET/CT can be a useful tool particularly at the time of initial RIT since the 18F-FDG accumulation enables the screening of high-risk DTC with poor prognosis at a very early time stage.

    DOI: 10.21873/anticanres.16148

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  • Prediction of pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma using 2-[<SUP>18</SUP>F]-fluoro-2-deoxy-D-glucose positron-emission tomography

    Tabata, K; Nishie, A; Shimomura, Y; Isoda, T; Kitamura, Y; Nakata, K; Yamada, Y; Oda, Y; Ishigami, K; Baba, S

    CLINICAL RADIOLOGY   77 ( 6 )   436 - 442   2022.6   ISSN:0009-9260 eISSN:1365-229X

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    AIM: To determine whether the pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) can be predicted using 2-[18F]-fluoro-2-deoxy-D-glucose positron-emission tomography (F-18 FDG-PET). MATERIALS AND METHODS: Twenty-eight patients with PDAC who underwent only neoadjuvant chemotherapy (NAC) before surgery were enrolled in the study. All patients had F-18 FDG-PET examinations before NAC. The resected specimen was pathologically evaluated according to the Classification of Pancreatic Carcinoma (7th edn). Patients were categorised into a non-response group and a response group based on the pathological findings. The non-response group (Grades 1a and 1b) showed ≤50% necrosis in the specimen, while the specimens of the response group (Grades 2–3) showed >50% necrosis. The maximum standardised uptake values (SUVmax) of the tumours on F-18 FDG-PET were measured. The mean values of SUVmax were compared between the two groups. The diagnostic performance of SUVmax in distinguishing the two groups was also evaluated using receiver operating characteristic analysis. RESULTS: The mean SUVmax of the response group was higher than that of the non-response group (9.00 ± 1.78 versus 4.26 ± 2.35; p<0.001). The optimal cut-off value of SUVmax was 9.28 for distinguishing the two groups. The sensitivity, specificity, and accuracy for the prediction in the response group were 80%, 95.7%, and 92.9%, respectively. CONCLUSIONS: SUVmax on F-18 FDG-PET may be useful as a biomarker to predict the pathological response to NAC in patients with PDAC.

    DOI: 10.1016/j.crad.2022.03.001

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  • 褐色細胞腫と副腎皮質腺腫の鑑別に、123IメタヨードベンジルグアニジンSPECT/CTによる半定量分析の有用性(Usefulness of semi-quantitative analysis in 123I metaiodobenzylguanidine SPECT/CT for the differentiation of pheochromocytoma and cortical adenoma)

    Kitamura Yoshiyuki, Baba Shingo, Isoda Takuro, Maruoka Yasuhiro, Sasaki Masayuki, Nishie Akihiro, Ishigami Kousei

    Annals of Nuclear Medicine   36 ( 1 )   95 - 102   2022.1   ISSN:0914-7187

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    2011年1月~2015年2月までの期間内に、当院で123I MIBG SPECT/CT検査を受けた、褐色細胞腫(PHEO)患者21例(男性10例、女性11例、年齢24~80歳)と、副腎皮質腺腫(CA)患者23例(男性15例、女性8例、年齢30~78歳)を対象に調査した。123Iメタヨードベンジルグアニジン(MIBG) SPECT/CT所見から、腫瘍と肝臓へ集積最大値の比(T/Lmax)、腫瘍と肝臓への集積平均値の比(T/Lmean)、腫瘍と骨格筋への集積最大値の比(T/Mmax)、腫瘍と骨格筋への集積平均値の比(T/Mmean)について、半定量的に解析した。その結果、ROC解析によるAUCでは、123I MIBGのプラナー画像の視覚スコアが0.833、SPECT画像の視覚スコアが0.813で、T/Lmaxが0.986、T/Lmeanが0.975、T/Mmaxが0.955、T/Mmeanが0.933であった。なかでも、T/MmaxのAUCでは、123I MIBGのプラナー画像の視覚スコアや、SPECT画像の視覚スコアに比べ、有意に高値が検出された。以上の解析結果から、PHEOとCAの鑑別に、123I MIBG SPECT/CTによる半定量分析が有用と判断された。

  • Usefulness of semi-quantitative analysis in <SUP>123</SUP>I metaiodobenzylguanidine SPECT/CT for the differentiation of pheochromocytoma and cortical adenoma

    Kitamura, Y; Baba, S; Isoda, T; Maruoka, Y; Sasaki, M; Nishie, A; Ishigami, K

    ANNALS OF NUCLEAR MEDICINE   36 ( 1 )   95 - 102   2022.1   ISSN:0914-7187 eISSN:1864-6433

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    Objective: 123I metaiodobenzylguanidine (MIBG) scintigraphy is a useful tool for the diagnosis of pheochromocytomas (PHEOs), but some PHEOs are difficult to differentiate from cortical adenoma (CA) or normal adrenal uptake by visual evaluation alone. A new semi-quantitative analysis using 123I MIBG SPECT/CT is thus expected. Herein, we introduce the tumor-to-liver count ratio (T/L) and the tumor-to-muscle count ratio (T/M). Methods: We examined the cases of 21 patients with PHEOs (10 males, 11 females; age 24–80, median 61 years) and 23 patients with CA (15 males and 8 females, age 30–78, median 58 years). The visual scoring based on 123I MIBG planar images (planar score) and SPECT images (SPECT score) was used as the conventional evaluation. Using 123I MIBG SPECT/CT findings, we calculated the semi-quantitative values of the count ratio using the maximum or mean count of the tumor and the liver or muscle as the reference organ (T/Lmax, T/Lmean, T/Mmax and T/Mmean). Each evaluation of the PHEOs and CAs was compared, and the diagnosing performance was evaluated based on an ROC analysis. Results: The area under curve (AUC) values were as follows: the planar score, 0.833; SPECT score, 0.813; T/Lmax, 0.986; T/Lmean, 0.975; T/Mmax, 0.955; and T/Mmean, 0.933. The AUC for T/Mmax was significantly higher than those of the planar score, and SPECT score by ROC analysis (p < 0.01 each). Conclusion: The semi-quantitative value of 123I MIBG SPECT/CT is more useful than the conventional visual evaluation for differentiating PHEOs from CAs.

    DOI: 10.1007/s12149-021-01690-9

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  • A functional scoring system based on salivary gland scintigraphy for evaluating salivary gland dysfunction secondary to 131I therapy in patients with differentiated thyroid carcinoma Reviewed

    Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Horoshi Honda

    Journal of Clinical and Diagnostic Research   11 ( 8 )   TC23 - TC28   2017.8

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    DOI: 10.7860/JCDR/2017/27340.10431

  • Association between volumetric analysis of lung metastases on F-18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography and short-term progression after i-131 therapy for differentiated thyroid carcinoma Reviewed

    Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda

    Indian Journal of Nuclear Medicine   32 ( 3 )   167 - 172   2017.7

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    DOI: 10.4103/ijnm.IJNM_43_17

  • Three-dimensional fractal analysis of 99m Tc-MAA SPECT images in chronic thromboembolic pulmonary hypertension for evaluation of response to balloon pulmonary angioplasty Association with pulmonary arterial pressure Reviewed

    Yasuhiro Maruoka, Michinobu Nagao, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Yuzo Yamazaki, Koichiro Abe, Masayuki Sasaki, Kotaro Abe, Hiroshi Honda

    Nuclear Medicine Communications   38 ( 6 )   480 - 486   2017.5

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    DOI: 10.1097/MNM.0000000000000673

  • Metabolic Tumor Volume by (18)F-FDG PET/CT Can Predict the Clinical Outcome of Primary Malignant Spine/Spinal Tumors Reviewed

    Yoshihiro Matsumoto, Shingo Baba, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Jun-Ichi Fukushi, Kenichi Kawaguchi, Seiji Okada, Hirofumi Bekki, Takuro Isoda, Yoshiyuki Kitamura, Hiroshi Honda, Yasuharu Nakashima

    BioMed Research International   2017   8132676   2017

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    DOI: 10.1155/2017/8132676

  • Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme Reviewed

    Koji Yamashita, Hiwatashi Akio, Osamu Togao, kazufumi kikuchi, Yoshiyuki Kitamura, Masahiro Mizoguchi, Koji Yoshimoto, Daisuke Kuga, Satoshi Suzuki, Shingo Baba, Takuro Isoda, Toru Iwaki, Koji Iihara, Hiroshi Honda

    Journal of Magnetic Resonance Imaging   44 ( 5 )   1256 - 1261   2016.11

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    DOI: 10.1002/jmri.25261

  • Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System, BONENAVI, on Bone Scintigraphy Images Reviewed International journal

    Takuro Isoda T, Shingo BaBa, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Masayuki Sasaki , Masamitsu Hatakenaka, Hiroshi Honda

    Asia Oceania Journal of Nuclear Medicine and Biology   2016.10

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  • Impact of patient age on the iodine/FDG “flip-flop” phenomenon in lung metastasis from thyroid cancer Reviewed

    30 ( 8 )   518 - 524   2016.10

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    Objectives: Radioiodine therapy is an effective treatment for lung metastasis from thyroid cancer. However, cases of lung metastasis without iodine uptake are often encountered. In such cases, FDG accumulation in lung lesions is often observed. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called “flip-flop” phenomenon. The aim of this study was to assess the relationship between patient age and the occurrence of the flip-flop phenomenon. Methods: Eighty-six patients who underwent radioiodine therapy for lung metastasis were studied retrospectively (age 17–73 years; median 60 years; males:females 22:64). We compared the clinical data and imaging findings (size and FDG uptake of lung nodules) between patients with (n = 44) and without (n = 42) iodine uptake in lung metastasis. Results: Significantly more young patients showed iodine accumulation in lung metastasis than old patients (p = 0.0025). Lung metastases with larger size or greater FDG uptake showed no iodine uptake more frequently with significant difference (p = 0.015 and <0.001, respectively). Among patients with FDG uptake in the lung metastasis, 57.1 % of young patients (<60 years) and 24.3 % of the old patients (≥60 years) showed iodine uptake (p = 0.0029). Conclusions: Higher patient age and lung nodules with large size or FDG accumulation are negative factors for iodine accumulation in lung metastases from thyroid cancer. In addition, our results show that young patients have a greater likelihood of iodine uptake even when FDG accumulates in lung metastasis, in contrast to old patients.

    DOI: 10.1007/s12149-016-1104-9

  • Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice. Reviewed International journal

    International Journal of Biological Sciences   10 ( 8 )   940 - 947   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7150/ijbs.9241. eCollection 2014.

  • Nabothian Cyst a Predominant Cause of False-Positive Iodine Uptake in Uterus Comparison of SPECT/CT and Pelvic MRI

    CLINICAL NUCLEAR MEDICINE   39 ( 8 )   2014.8

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    Language:English  

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Books

  • 核医学検査技術第4版

    佐々木雅之、馬場眞吾、藤淵俊王、山田明史、赤松剛、北村宜之、丸岡保博、磯田拓郎( Role: Joint author)

    2021.11 

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    Language:Japanese   Book type:Scholarly book

  • 核医学検査技術第3版

    磯田 拓郎( Role: Joint author)

    南山堂  2015.2 

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    Language:Japanese   Book type:General book, introductory book for general audience

Presentations

  • Deep Learningを用いた再構成法に影響する患者要因の検討

    磯田拓郎, 北村宜之, 楠正興, 三道幹大, 馬場眞吾, 石神康生

    日本核医学会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • Impacts of clinical and imaging factors on the outcomes of radioiodine therapy for the patients with bone metastasis from thyroid cancer International conference

    Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Kosei Ishigami

    Society of Nuclear Medicine and Molecular Imaging  2023.6 

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    Event date: 2024.4

    Language:English  

    Country:United States  

  • 甲状腺癌肺転移に対する放射性ヨウ素内用療法:治療効果が良好な症例の特徴

    磯田拓郎、馬場眞吾、丸岡保博、北村宜之、佐々木雅之、石神康生

    日本核医学会学術総会  2021.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市   Country:Japan  

  • ヨウ素の唾液腺集積と放射性ヨウ素内用療法の前処置の関係

    磯田拓郎、馬場眞吾、北村宜之、真鍋裕介、佐々木雅之、西江昭弘

    日本核医学会総会  2019.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛媛県松山市   Country:Japan  

  • Interval change in the degree of iodine uptake in lung metastasis from thyroid cancer between first and second radioiodine therapy; pulmonary uptake first emerges at the second radioiodine therapy in some patients International conference

    Takuro Isoda, Shingo Baba, Yoshiyuki Kitamura, Ryo Somehara, Masayuki Sasaki, Hiroshi Honda

    Society of Nuclear Medicine and Molecular Imaging 2019 Annual Meeting  2019.6 

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    Event date: 2020.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 131I/18FDG Flip-Flop Phenomenon in the Bone Metastasis from Differentiated Thyroid Cancer International conference

    Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Kousei Ishigami

    Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting  2020.7 

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    Event date: 2020.5 - 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 99mTc-macroaggregated albumin (MAA)を用いた肺血流シンチグラフィにて椎体に高集積を示した上大静脈症候群の1例

    磯田拓郎、馬場眞吾、丸岡保博、北村宜之、眞鍋裕介、佐々木雅之、西江昭弘

    日本核医学会九州地方会  2020.2 

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    Event date: 2020.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀市   Country:Japan  

  • FDG-PET of drive line infection and non-pathological uptake in or around a ventricular assist device International conference

    Takuro Isoda, Shingo Baba, Yoshiyuki Kitamura, Ryo Somehara, Keiichiro Tahara, Masayuki Sasaki, Hiroshi Honda

    SNMMI2018  2018.6 

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    Event date: 2019.6

    Language:Japanese  

    Country:United States  

  • Occurrence rate of pulmonary uptake which first emerges in the second radioiodine therapy

    2018.11 

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    Event date: 2019.6

    Language:Japanese  

    Country:Japan  

  • Prediction of salivary gland disorder after radioiodine therapy with the evaluation of iodine uptake in salivary glands on iodine scintigraphy International conference

    Takuro Isoda, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Masayuki Sasaki, Masasmitsu Hatakenaka, Hiroshi Honda

    SNMMI2016  2016.6 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • FDGの肝・縦隔の集積と年齢の関係

    磯田拓郎、馬場眞吾、北村宜之、染原 涼、田原圭一郎、佐々木雅之、本田 浩

    日本核医学会総会  2017.10 

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    Event date: 2017.7 - 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    悪性リンパ腫のFDG—PET評価でDeauville 5-point score (5-PS)が広く用いられている。小児では肝集積が低いため、この判定法をそのまま当てはめることは難しい。本研究では肝集積と年齢の関係を解析し、Deauville 5-PSへの影響を検証した。【方法】55名の肝のSUVmaxを測定し、11群(0-3、4-6、7-9、10-12、13-15、16-18、19-21、22-24、25-29、30-34、35-39歳)の間で比較した。【結果】肝のSUVmaxの平均値は0-4歳:0.96、4-6歳:1.2、7-19歳:1.6、10-12歳:2.1、13-15歳:2.5、16-18歳:2.9、19-21歳:3.2、22-24歳:3.2、25-29歳:3.3、30-34歳:3.2、35-39歳:3.2であった。【結論】肝のFDG集積は18歳以下の群で低く、Deauville 5-PSでは、治療の対象となるスコア4以上に過大評価される可能性がある。

  • Impact of the patient age on flip-flop phenomenon in lung metastasis from thyroid cancer International conference

    Europian Congress of Radiology  2015.3 

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    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  • 甲状腺癌骨転移病変への放射性ヨウ素集積;FDG集積との関係 Invited

    磯田 拓郎

    日本核医学会総会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

    甲状腺癌病変にFDG集積を認める場合に放射性ヨウ素が集積し難いことは、いわゆるflip-flop 現象として知られている。これまでリンパ節や肺病変でこの現象を確認した。本研究では骨病変で解析した。【方法】甲状腺癌骨転移に対し放射性ヨウ素内用療法を施行し、同時期にFDG-PETを撮影した患者10名(男:女=4:6、29-70歳、中央値;56.5歳)、77病変を対象とした。ヨウ素集積の有無とFDG集積程度を比較した。【結果】8例で骨転移巣にヨウ素の集積を認めた。ヨウ素集積を認めた病変でも比較的高いFDG集積を示した(SUVmax中央値;4.68)。高いFDG集積(SUVmax>5)を示す病変も26病変(43.2%)認めた。ヨウ素集積の無い病変(SUVmax中央値;9.30)は、ヨウ素集積のあった病変に比し、有意に高いFDG異常集積を示した(p<0.00001)。【結論】骨転移においてもヨウ素集積を認めない病変が認める病変に比し高いFDG集積を示すが、高いFDG集積を認めても、骨転移では比較的高い頻度でヨウ素集積を認める。

  • Evaluation of Diagnostic Performance of a Computer-Aided Diagnostic System, BONENAVI, on bone scintigraphy images International conference

    Annual Meeting 2015 of Society of Nuclear Medicine and Molecular Imaging  2014.6 

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    Event date: 2014.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 3D U-netを用いた全身FDG-PET/CTの高精度腫瘍セグメンテーションの自動化(Automated high accuracy tumor segmentation of whole-body FDG-PET/CT using 3D U-net)

    Baba Shingo, Isoda Takuro, Kitamura Yoshiyuki, Kusunoki Masaoki, Sandou Motohiro, Ishii Hideaki, Yamane Toshimizu, Ueno Shunya, Ishigami Kosei

    核医学  2023  (一社)日本核医学会

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  • 99mTc-macroaggregated albumin(MAA)を用いた肺血流シンチグラフィにて椎体に高集積を示した上大静脈症候群の1例

    磯田 拓郎, 馬場 眞吾, 丸岡 保博, 北村 宜之, 眞鍋 裕介, 西江 昭弘, 佐々木 雅之

    Japanese Journal of Radiology  2022.2  (公社)日本医学放射線学会

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  • Analogue PET/CT, Digital PET/CT撮像装置における動脈FDG集積の比較検討

    金子 恒一郎, 馬場 眞吾, 磯田 拓郎, 添田 博康, 花田 清彦, 石岡 久和

    Japanese Journal of Radiology  2022.2  (公社)日本医学放射線学会

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  • Deep Learningを用いた再構成法に影響する患者要因の検討

    磯田 拓郎, 北村 宜之, 楠 正興, 三道 幹大, 吉留 郷志, 馬場 眞吾, 石神 康生

    核医学  2023  (一社)日本核医学会

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  • FDG-PET/CTが診断に寄与したTAFRO症候群の1例

    中村 勇星, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 石神 康生, 陳之内 文昭, 山元 英崇

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • FDG-PETにて高集積を呈したEpithelioid angiomyolipoma(eAML)の1例

    大島 健史, 馬場 眞吾, 北村 宜之, 丸岡 保博, 磯田 拓郎, 石神 康生, 今田 憲二郎, 孝橋 賢一

    Japanese Journal of Radiology  2023.2  (公社)日本医学放射線学会

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  • 体動補正機能を用いたFDG-PET/CT肺病変撮像の有用性 息止め撮像との比較

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 眞鍋 裕介, 神谷 武志, 西江 昭弘, 佐々木 雅之

    Japanese Journal of Radiology  2022.2  (公社)日本医学放射線学会

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  • 前立腺のFDG集積 排尿前撮像による尿中FDG逆流の証明

    磯田 拓郎, 馬場 眞吾, 丸岡 保博, 北村 宜之, 佐々木 雅之, 石神 康生

    核医学  2022.8  (一社)日本核医学会

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  • 心臓移植後左室心筋FDG集積の検討

    北村 宜之, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 石神 康生, 藤野 剛雄, 佐々木 雅之

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • 機械学習を用いた悪性リンパ腫のFDG-PET画像のMTV測定の有用性

    馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 佐々木 雅之, 石神 康生

    核医学  2022.8  (一社)日本核医学会

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  • 甲状腺癌に対する放射性ヨウ素内用療法において子宮筋腫に強いヨウ素集積を認めた1例

    井上 紗也香, 馬場 眞吾, 磯田 拓郎, 丸岡 保博, 北村 宜之, 牛島 泰宏, 石神 康生, 佐々木 雅之

    Japanese Journal of Radiology  2024.2  (公社)日本医学放射線学会

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  • 脱髄疾患との鑑別にmethionine PETが有用だった脳幹部神経膠腫の一例

    原 佑碩, 近藤 大祐, 園田 和隆, 田中 正人, 野中 崇久, 昇 竜正, 牧園 剛大, 中村 英夫, 磯田 拓郎, 川尻 真和

    臨床神経学  2024.3  (一社)日本神経学会

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    Language:Japanese  

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MISC

Professional Memberships

  • 日本核医学会

  • 日本医学放射線学会

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:6

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

Research Projects

  • Stable manufacture of Radiopharmaceuticals labeled with Cyclotron Produced Gallium-68

    Grant number:24K10839  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • メチオニンPETとAPTイメージングの統合による新たな脳腫瘍診断方法の開発

    Grant number:24K10763  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    楠 正興, 北村 宜之, 三道 幹大, 磯田 拓郎, 栂尾 理, 山田 明史, 石神 康生

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    Grant type:Scientific research funding

    脳腫瘍の特異なアミノ酸代謝を画像化するメチオニンPET(Positron Emission Tomography) は、腫瘍の進展範囲や再発診断などにその有用性が報告されてきた。しかしながら、現時点で主流である静的撮像法(Static Imaging)による術前の腫瘍悪性度の正確な評価は困難とされており、依然発展途上の課題である。本研究では、動的撮像法(Dynamic imaging)により新たな診断パラメータを探索し、これを先進的な分子イメージング技術であるAPT (Amide Proton Transfer)イメージングと統合することで、この課題を克服し悪性度評価の精度向上を目的とする。

    CiNii Research

  • 左心補助人工心臓装着に伴う感染症に対するFDG-PET/CTを用いた新たな診断方法の確立

    Grant number:23K07182  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    北村 宜之, 磯田 拓郎, 楠 正興, 山田 明史, 馬場 眞吾, 石神 康生

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    Grant type:Scientific research funding

    左室補助人工心臓(LVAD)の装着が必要となっている患者さんにおいて、LVAD装着後の合併症の一つである装着部の感染症があるが、CT検査など従来の画像検査ではその診断が困難である。本研究では、核医学を用いた検査の一つで、すでに国内でも広く利用されているFDG(F-18 Fluorodeoxyglucose)を用いた検査(FDG-PET/CT)をLVAD装着後の患者さんに行い、検査結果を詳しく調べることで、LVAD装着後感染症の診断に有用な画像診断法を確立する。

    CiNii Research

  • Novel imaging method for prostate cancer using 89Zr-PSMA-PET

    Grant number:21K07622  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant type:Scientific research funding

    CiNii Research

  • アミノ酸イメージングの拡大を目指した18F標識アミノ酸の新規合成法の確立

    Grant number:19K08100 

    山田 明史, 北村 宜之, 馬場 眞吾, 磯田 拓郎

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    Grant type:Scientific research funding

    18F-FPheおよび18F-FAMTはアミノ酸トレーサーとして脳組織および種々の腫瘍などのアミノ酸輸送過程を、定量的あるいは定性的に診断する薬剤として使用される。現在、18F-FPheおよび18F-FAMTは18F-F2ガスから合成されているが、この方法では1回の合成で得られる放射能量や比放射能が著しく低い。18Fアニオン(18F-)から18F-FPheと18F-FAMTの合成することができれば、この課題は克服できる。

    CiNii Research

Class subject

  • 系統講義「神経」核医学

    2023.10 - 2024.3   Second semester

  • 系統医学「放射線医学」核医学

    2023.10 - 2024.3   Second semester

  • 医工学入門

    2023.4 - 2023.9   First semester

  • 医学部5年生臨床実習

    2022.4 - 2023.3   Full year

  • 医学部6年CCS

    2022.4 - 2022.9   First semester

  • 医工学入門

    2022.4 - 2022.9   First semester

  • 医学部6年生 CCS

    2021.4 - 2022.3   Full year

  • 医学部5年生臨床実習

    2021.4 - 2022.3   Full year

  • 医工学入門

    2021.4 - 2021.9   First semester

  • 医学部5年生臨床実習

    2020.4 - 2021.3   Full year

  • 医学部6年生 CCS

    2020.4 - 2021.3   Full year

  • 医工学入門

    2020.4 - 2020.9   First semester

  • 医学部6年 CCS

    2019.4 - 2020.3   Full year

  • 医学部5年 臨床実習

    2019.4 - 2020.3   Full year

  • 医工学入門

    2019.4 - 2019.9   First semester

  • 医学部5年 臨床実習I

    2018.4 - 2019.3   Full year

  • 医学部6年 CCS

    2018.4 - 2019.3   Full year

  • 医工学入門

    2018.4 - 2018.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • 九州大学病院に甲状腺癌に対するアイソトープ治療を行い、県内外からの患者を受け入れている。また、近年ではアイソトープ治療を受ける外国人患者が増加している。
    放射線診断医、核医学専門医の不足する施設への補助、指導。
    核医学治療に関する情報提供を講演会等で行なっている。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Radiology

Clinician qualification

  • Specialist

    Japan Radiological Society(JRS)

  • Specialist

    Japanese Society of Nuclear Medicine(JSNM)

  • Specialist

    日本核医学会

Year of medical license acquisition

  • 2000