Updated on 2026/08/04

Information

 

写真a

 
MIYAWAKI KOHTA
 
Organization
Kyushu University Hospital Center for Cellular and Molecular Medicine Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425947
Profile
Hematology Practice Basic research related to hematopoietic malignancies
Homepage
External link

Research Areas

  • Life Science / Hematology and medical oncology

Degree

  • Ph.D.

  • M.D.

Research Interests・Research Keywords

  • Research theme: Pathobiology of relapse after CAR-T cell therapy

    Keyword: CAR-T細胞療法; 治療抵抗性; 空間的single-cell解析

    Research period: 2023.4

  • Research theme: Pathophysiology of hematopoietic tumors

    Keyword: hematologic malignancies, lymphoma, leukemia

    Research period: 2021.4 - 2022.7

  • Research theme: Tumor immune microenvironment of malignant lymphoma

    Keyword: びまん性大細胞型B細胞リンパ腫; 腫瘍免疫微小環境; DMSスコア; 空間トランスクリプトーム

    Research period: 2018.4

  • Research theme: Differentiation hierarchy of hematopoietic stem and progenitor cells

    Keyword: 造血幹細胞; 巨核球前駆細胞; 分化階層

    Research period: 2010.4

Awards

  • 奨励賞(第40回日本造血細胞移植学会総会)

    2019.3   日本造血細胞移植学会  

     More details

    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 奨励賞

    2018.10   日本血液学会  

     More details

    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 優秀賞(第6回日本血液学会国際シンポジウム)

    2015.5   日本血液学会  

     More details

    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  • ASH Abstract Achievement Award

    2012.12   American Society of Hematology  

     More details

    Award type:Award from international society, conference, symposium, etc.  Country:United States

Papers

  • Engraftment syndrome after PD-1 blockade in classical Hodgkin lymphoma treated by autologous stem cell transplantation. Reviewed

    Choi H, Yamauchi T, Mori Y, Matsuo C, Nishihara H, Irifune H, Nakao F, Ishihara D, Imanaga H, Sasaki K, Sakoda T, Jinnouchi F, Miyawaki K, Shima T, Kikushige Y, Akashi K, Kato K

    Int J Hematol   123 ( 1 )   135 - 140   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-025-04094-x

  • Real-World Safety and Efficacy of Pola-R-CHP in Previously Untreated DLBCL: POLASTAR Interim Analysis of 500 Patients. Reviewed

    Kumode T, Sawa H, Miyawaki K, Satake A, Kanemura N, Suzuki R, Fujiwara Y, Nagate Y, Ota S, Fujino T, Goto H, Fukuhara N, Sakata-Yanagimoto M, Izutsu K, Nishikori M, Shibayama H, Ennishi D, Shimose T, Asai M, Matsumura I, Akashi K, Kato K

    Cancer Sci   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.70484

  • Early prediction of ICANS using CRS characteristics in B-cell lymphoma patients receiving CAR-T therapy. Reviewed

    Nishihara H, Jinnouchi F, Ishihara D, Imanaga H, Sasaki K, Sakoda T, Yamauchi T, Miyawaki K, Shima T, Shimo M, Henzan T, Kunisaki Y, Kikushige Y, Mori Y, Akashi K, Kato K

    Int J Hematol   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-026-04257-4

  • Gene expression profile of adult T-cell leukemia/lymphoma with human T-cell lymphotropic virus type 1-infected Hodgkin and Reed-Sternberg-like cells is more similar to classic Hodgkin lymphoma than typical adult T-cell leukemia/lymphoma. Reviewed

    Miyagi S, Mori K, Miyawaki K, Shimo M, Tamaki T, Sakihama S, Takatori M, Akashi K, Karube K, Kato K

    Haematologica   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3324/haematol.2025.289270

  • p62/SQSTM1 Accumulation Defines an Epithelial-Mesenchymal Transition (EMT)/Twist1-Associated Infiltrative Phenotype in Pancreatic Neuroendocrine Tumors. Reviewed

    Matsumoto T, Yamamoto T, Osajima S, Nakanishi Y, Noguchi S, Mizuuchi Y, Murakami M, Ueda K, Takigawa K, Shimo M, Miyawaki K, Kato K, Fujimori N, Nakata K, Aishima S, Oda Y

    Mod Pathol   39 ( 6 )   101001   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.modpat.2026.101001

  • Safety and effectiveness of lisocabtagene maraleucel following PD-1 blockade in relapsed or refractory PMBCL. Reviewed

    Yamaguchi K, Yamauchi T, Hirakawa S, Nakagaki H, Nishihara H, Shimo M, Sasaki K, Sakoda T, Jinnouchi F, Miyawaki K, Shima T, Kikushige Y, Mori Y, Akashi K, Kato K

    Int J Hematol   123 ( 5 )   737 - 745   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-025-04148-0

  • Preliminary analysis of a multicenter study of Pola-R-CHP in untreated Japanese patients with DLBCL (POLASTAR). Reviewed

    Satake A, Nagate Y, Miyawaki K, Fujiwara Y, Ota S, Muta T, Rai S, Tsurumi H, Suzuki R, Miyake T, Goto H, Fukuhara N, Sakata-Yanagimoto M, Izutsu K, Nishikori M, Shibayama H, Kumode T, Ennishi D, Shimose T, Inubashiri N, Matsumura I, Akashi K, Kato K

    Int J Hematol   123 ( 3 )   404 - 411   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-025-04122-w

  • Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T-Cell Exhaustion in Dysgerminoma. Reviewed

    Nakashima M, Iwasaki T, Katayama Y, Shimo M, Takigawa K, Shimada N, Matsushita M, Kuwamoto S, Sato S, Toya M, Miyawaki K, Akashi K, Kato K, Oda Y

    Cancer Sci   117 ( 2 )   566 - 575   2026

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.70281

  • Burkitt in disguise: clonal transformation of incidentally detected gallbladder diffuse large B-cell lymphoma in a liver transplant recipient. Reviewed

    Miyawaki K, Nakagaki H, Mori Y, Semba Y, Hirakawa S, Yamaguchi K, Nishihara H, Sasaki K, Sakoda T, Jinnouchi F, Yamauchi T, Shima T, Maeda T, Akashi K, Kato K

    Int J Hematol   122 ( 6 )   911 - 916   2025

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-025-04078-x

  • The effective and safe administration of Epcoritamab in relapsed CD19-CD5+ DLBCL following CAR-T therapy. Reviewed

    Shimakawa T, Kawano N, Semba Y, Mori Y, Takigawa K, Yamauchi T, Miyawaki K, Jinnouchi F, Sakoda T, Mori K, Shimo M, Otsu M, Ikeda R, Shiraishi S, Nakaike T, Yamashita K, Mashiba K, Kikuchi I, Marutsuka K, Ohshima K, Matsuzaki S, Karube K, Kato K, Maeda T, Akashi K

    Blood Cell Ther   8 ( 3 )   244 - 249   2025

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.31547/bct-2024-037

  • Objective quantification of pre-CAR-T EEG abnormalities for ICANS prognosis: insights from GTE scoring. Reviewed

    Nakagaki H, Yamauchi T, Mukaino T, Sakata A, Watanabe E, Watanabe M, Ishihara D, Imanaga H, Sasaki K, Sakoda T, Jinnouchi F, Miyawaki K, Shima T, Kikushige Y, Mori Y, Hotta T, Kunisaki Y, Shigeto H, Isobe N, Akashi K, Kato K

    Bone Marrow Transplant   60 ( 7 )   1076 - 1078   2025

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-025-02616-z

  • Indirect presentation of mismatched human leukocyte antigen-B associates with outcomes of cord blood transplantation. Reviewed

    Sugio T, Miyawaki K, Uchida N, Niemann M, Spierings E, Mori K, Ohno Y, Eto T, Mori Y, Yoshimoto G, Kikushige Y, Kunisaki Y, Mizuno S, Nagafuji K, Iwasaki H, Kamimura T, Ogawa R, Miyamoto T, Taniguchi S, Akashi K, Kato K

    Br J Haematol   206 ( 5 )   1406 - 1417   2025

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bjh.20035

  • Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy. Reviewed

    Nomiyama T, Setoyama D, Yamanaka I, Shimo M, Miyawaki K, Yamauchi T, Jinnouchi F, Sakoda T, Sasaki K, Shima T, Kikushige Y, Mori Y, Akashi K, Kato K, Kunisaki Y

    Leukemia   39 ( 4 )   983 - 987   2025

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41375-025-02541-6

  • Distinct leukemogenic mechanism of acute promyelocytic leukemia based on genomic structure of PML::RARα. Reviewed

    Minami M, Sakoda T, Kawano G, Kochi Y, Sasaki K, Sugio T, Jinnouchi F, Miyawaki K, Kunisaki Y, Kato K, Miyamoto T, Akashi K, Kikushige Y

    Leukemia   39 ( 4 )   844 - 853   2025

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41375-025-02530-9

  • 再発リンパ腫組織内のCAR-T細胞の姿を捉える Reviewed

    瀧川 健, 宮脇 恒太, 谷口 志保, 福島 伯泰, 岩崎 健, 加藤 光次, 赤司 浩一

    臨床血液   66 ( 4 )   303 - 304   2025

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • A Case of Intractable Lower Leg Ulcer with Idiopathic Multicentric Castleman's Disease

    SUGI Yuta, YAMAMURA Kazuhiko, TAKEI Itsuki, NAKAHARA Makiko, ICHIKI Toshio, MIYAWAKI Kota, YAMAMOTO Hidetaka, YAMAMURA Mika, NAKAHARA Takeshi

    The Nishinihon Journal of Dermatology   86 ( 3 )   233 - 237   2024.6   ISSN:03869784 eISSN:18804047

     More details

    Language:Japanese   Publisher:Western Division of Japanese Dermatological Association  

    <p>47 歳,男性。約 2 年前より左下腿に潰瘍が出現し,拡大傾向であったため約 1 年前に前医を受診した。 外用治療を行われるも難治であり,潰瘍は徐々に拡大したため当科を紹介され受診し,精査加療目的に入院となった。入院時,左下腿の腫脹とほぼ全周にわたる潰瘍に加え,発熱,全身倦怠感,貧血,低栄養を認めた。背景の基礎疾患を検索したところ,血清 IL-6 値の上昇と CT 検査上,左鼠径部から傍大動脈周囲にかけて多発するリンパ節腫大を認めた。左鼠径部リンパ節生検を施行したところ,病理組織学的に硝子血管型 Castleman 病が疑われ,ほかの所見と合わせて特発性多中心性 Castleman 病と診断した。プレドニゾロン(PSL)15 mg/ 日の内服を開始し,発熱と全身倦怠感は改善傾向となった。潰瘍に対しては感染のコントロールを行い,デブリードマンおよび分層植皮術を施行した。2 回の分層植皮術と局所の圧迫,外用治療で潰瘍はほぼ上皮化し,PSL は徐々に減量した。Castleman 病と下腿潰瘍の合併は比較的稀ではあるが,全身症状を伴う難治性の下腿潰瘍に対しては本症を疑う必要があると考えた。</p>

    DOI: 10.2336/nishinihonhifu.86.233

    Scopus

    CiNii Research

  • Reply to "Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis". Reviewed

    Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T

    J Gastroenterol   59 ( 1 )   77 - 78   2024

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-023-02064-w

  • Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome. Reviewed

    Ono-Minagi H, Nohno T, Takabatake K, Tanaka T, Katsuyama T, Miyawaki K, Wada J, Ibaragi S, Iida S, Yoshino T, Nagatsuka H, Sakai T, Ohuchi H

    BMC Oral Health   24 ( 1 )   1099   2024

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12903-024-04869-4

  • A case of successful CAR-T cell therapy for early isolated CNS recurrence of DLBCL with persistent CAR-T cells. Reviewed

    Takigawa K, Kawano N, Mori Y, Yamauchi T, Tochigi T, Miyawaki K, Mori K, Shimo M, Nakaike T, Yamashita K, Mashiba K, Kikuchi I, Marutsuka K, Ohshima K, Kato K, Akashi K

    Blood Cell Ther   7 ( 2 )   37 - 40   2024

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.31547/bct-2023-032

  • Co-expression of regulatory B-cell markers, transforming growth factor β and interleukin-10 as a prognostic factor in diffuse large B-cell lymphoma. Reviewed

    Mishina T, Miyoshi H, Takeuchi M, Miyawaki K, Nakashima K, Yamada K, Moritsubo M, Inoue-Mitsuyama K, Shimasaki Y, Imamoto T, Kawamoto K, Furuta T, Kohno K, Kato K, Akashi K, Ohshima K

    Pathol Res Pract   254   155117   2024

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2024.155117

  • Prognostic impact of HLA supertype mismatch in single-unit cord blood transplantation. Reviewed

    Sugio T, Uchida N, Miyawaki K, Ohno Y, Eto T, Mori Y, Yoshimoto G, Kikushige Y, Kunisaki Y, Mizuno S, Nagafuji K, Iwasaki H, Kamimura T, Ogawa R, Miyamoto T, Taniguchi S, Akashi K, Kato K

    Bone Marrow Transplant   59 ( 4 )   466 - 472   2024

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41409-023-02183-1

  • Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance

    Nakao Fumihiko, Setoguchi Kiyoko, Semba Yuichiro, Yamauchi Takuji, Nogami Jumpei, Sasaki Kensuke, Imanaga Hiroshi, Terasaki Tatsuya, Miyazaki Manaka, Hirabayashi Shigeki, Miyawaki Kohta, Kikushige Yoshikane, Masuda Takeshi, Akashi Koichi, Maeda Takahiro

    Leukemia   37 ( 5 )   1028 - 1038   2023.3   ISSN:08876924 eISSN:14765551

     More details

    Language:English   Publisher:Springer  

    To identify molecules/pathways governing Venetoclax (VEN) sensitivity, we performed genome-wide CRISPR/Cas9 screens using a mouse AML line insensitive to VEN-induced mitochondrial apoptosis. Levels of sgRNAs targeting March5, Ube2j2 or Ube2k significantly decreased upon VEN treatment, suggesting synthetic lethal interaction. Depletion of either Ube2j2 or Ube2k sensitized AML cells to VEN only in the presence of March5, suggesting coordinate function of the E2s Ube2j2 and Ube2k with the E3 ligase March5. We next performed CRISPR screens using March5 knockout cells and identified Noxa as a key March5 substrate. Mechanistically, Bax released from Bcl2 upon VEN treatment was entrapped by Mcl1 and Bcl-XL and failed to induce apoptosis in March5 intact AML cells. By contrast, in March5 knockout cells, liberated Bax did not bind to Mcl1, as Noxa likely occupied Mcl1 BH3-binding grooves and efficiently induced mitochondrial apoptosis. We reveal molecular mechanisms underlying AML cell-intrinsic VEN resistance and suggest a novel means to sensitize AML cells to VEN.

    DOI: 10.1038/s41375-023-01879-z

    Web of Science

    Scopus

    PubMed

    CiNii Research

  • Human acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function. Reviewed

    Kikushige Y, Miyamoto T, Kochi Y, Semba Y, Ohishi M, Irifune H, Hatakeyama K, Kunisaki Y, Sugio T, Sakoda T, Miyawaki K, Kato K, Soga T, Akashi K

    Blood Adv   7 ( 14 )   3592 - 3603   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/bloodadvances.2022008242

  • Impact of a third dose of anti-SARS-CoV-2 vaccine in hematopoietic cell transplant recipients: A Japanese multicenter observational study. Reviewed

    Mori Y, Uchida N, Wake A, Miyawaki K, Eto T, Nakamura T, Iwasaki H, Ito Y, Tanimoto K, Katayama Y, Imamura Y, Takahashi T, Fujisaki T, Kamimura T, Choi I, Ishitsuka K, Yoshimoto G, Ogawa R, Sugita J, Takamatsu Y, Tanimoto K, Hidaka T, Miyamoto T, Akashi K, Nagafuji K

    Vaccine   41 ( 47 )   6899 - 6903   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.vaccine.2023.08.066

  • Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis. Reviewed

    Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T

    J Gastroenterol   58 ( 9 )   868 - 882   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-023-02016-4

  • RHAMM marks proliferative subpopulation of human colorectal cancer stem cells. Reviewed

    Nakano M, Taguchi R, Kikushige Y, Isobe T, Miyawaki K, Mizuno S, Tsuruta N, Hanamura F, Yamaguchi K, Yamauchi T, Ariyama H, Kusaba H, Nakamura M, Maeda T, Kuo CJ, Baba E, Akashi K

    Cancer Sci   114 ( 7 )   2895 - 2906   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15795

  • Five-year follow-up of a phase II study of DA-EPOCH-R with high-dose MTX in CD5-positive DLBCL. Reviewed

    Miyazaki K, Sakai R, Iwaki N, Yamamoto G, Murayama K, Nishikori M, Sunami K, Yoshida I, Yano H, Takahashi N, Okamoto A, Munemoto S, Sawazaki A, Suehiro Y, Fukuhara N, Wake A, Arai A, Masaki Y, Toyama K, Yokoyama A, Tsunemine H, Hasegawa Y, Matsumoto K, Yamada T, Nishimura Y, Tamaru S, Asano N, Miyawaki K, Izutsu K, Kinoshita T, Suzuki R, Ohshima K, Kato K, Katayama N, Yamaguchi M

    Cancer Sci   114 ( 6 )   2689 - 2691   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15784

  • Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus. Reviewed

    Fujimoto S, Arinobu Y, Miyawaki K, Ayano M, Mitoma H, Kimoto Y, Ono N, Akashi K, Horiuchi T, Niiro H

    Rheumatology (Oxford)   62 ( 10 )   3480 - 3489   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/rheumatology/kead082

  • Successful pseudo-autologous stem cell transplantation for donor-derived Burkitt lymphoma occurring 9 years after allogeneic transplantation. Reviewed

    Taniguchi S, Utsumi S, Kochi Y, Taya Y, Mori Y, Semba YI, Sugio T, Miyawaki K, Kikushige Y, Kunisaki Y, Yoshimoto G, Numata A, Kato K, Uchida N, Maeda T, Miyamoto T, Taniguchi S, Akashi K

    Int J Hematol   117 ( 2 )   287 - 292   2023

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-022-03458-x

  • Prognostic value of pre-transplantation total metabolic tumor volume on (18)fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography in relapsed and refractory aggressive lymphoma Invited Reviewed International journal

    Sugio, Takeshi; Baba, Shingo; Mori, Yasuo; Yoshimoto, Goichi; Kamesaki, Kenjiro; Takashima, Shuichiro; Urata, Shingo; Shima, Takahiro; Miyawaki, Kohta; Kikushige, Yoshikane; Kunisaki, Yuya; Numata, Akihiko; Takenaka, Katsuto; Iawasaki, Hiromi; Miyamoto, Toshihiro; Ishigami, Kousei; Akashi, Koichi; Kato, Koji

    INTERNATIONAL JOURNAL OF HEMATOLOGY   116 ( 4 )   603 - 611   2022.6   ISSN:0925-5710 eISSN:1865-3774

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:International Journal of Hematology  

    Relapsed and refractory aggressive lymphoma have a poor prognosis. High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) is effective in chemosensitive patients. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is among the few options for non-chemosensitive patients. <sup>18</sup>Fluoro-2-deoxy-d-glucose positron emission tomography–computed tomography (<sup>18</sup>FDG-PET/CT) is the standard tool for evaluating response to chemotherapy and residual tumor volume. However, accurate assessment of residual tumor volume is not currently being achieved in clinical practice, and its value in prognostic and therapeutic stratification remains unclear. To answer this question, we investigated the efficacy of quantitative indicators, including total metabolic tumor volume (TMTV), in predicting prognosis after auto-HSCT and allo-HSCT. We retrospectively analyzed 39 patients who received auto-HSCT and 28 who received allo-HSCT. In the auto-HSCT group, patients with a higher TMTV had a poor prognosis due to greater risk of relapse. In the allo-HSCT group, patients with a higher TMTV had a lower progression-free survival rate and a significantly higher relapse rate. Neither Deauville score nor other clinical parameters were associated with prognosis in either group. Therefore, pre-transplant TMTV on PET is effective for prognostic prediction and therapeutic decision-making for relapsed or refractory aggressive lymphoma.

    DOI: 10.1007/s12185-022-03394-w

    Web of Science

    Scopus

    PubMed

  • A germinal center-associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL Invited Reviewed International journal

    Miyawaki, Kohta; Kato, Koji; Sugio, Takeshi; Sasaki, Kensuke; Miyoshi, Hiroaki; Semba, Yuichiro; Kikushige, Yoshikane; Mori, Yasuo; Kunisaki, Yuya; Iwasaki, Hiromi; Miyamoto, Toshihiro; Kuo, Frank C.; Aster, Jon C.; Ohshima, Koichi; Maeda, Takahiro; Akashi, Koichi

    BLOOD ADVANCES   6 ( 7 )   2388 - 2402   2022.4   ISSN:2473-9529 eISSN:2473-9537

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Blood Advances  

    Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell malignancy, with varying prognosis after the gold standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Several prognostic models have been established by focusing primarily on characteristics of lymphoma cells themselves, including cell-of-origin (COO), genomic alterations, and gene/protein expressions. However, the prognostic impact of the lymphoma microenvironment and its association with characteristics of lymphoma cells are not fully understood. Using the nCounter-based gene expression profiling of untreated DLBCL tissues, we assess the clinical impact of lymphoma microenvironment on the clinical outcomes and pathophysiological, molecular signatures in DLBCL. The presence of normal germinal center (GC)-microenvironmental cells, including follicular T cells, macrophage/dendritic cells, and stromal cells in lymphoma tissue indicates a positive therapeutic response. Our prognostic model, based on quantitation of transcripts from distinct GC-microenvironmental cell markers, clearly identified patients with graded prognosis independently of existing prognostic models. We observed increased incidences of genomic alterations and aberrant gene expression associated with poor prognosis in DLBCL tissues lacking GC-microenvironmental cells relative to those containing these cells. These data suggest that the loss of GC-associated microenvironmental signature dictates clinical outcomes of DLBCL patients reflecting the accumulation of “unfavorable” molecular signatures.

    DOI: 10.1182/bloodadvances.2021004618

    Web of Science

    Scopus

    PubMed

  • Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions Invited Reviewed International journal

    Ito, Mamoru; Nakano, Michitaka; Ariyama, Hiroshi; Yamaguchi, Kyoko; Tanaka, Risa; Semba, Yuichiro; Sugio, Takeshi; Miyawaki, Kohta; Kikushige, Yoshikane; Mizuno, Shinichi; Isobe, Taichi; Tanoue, Kenro; Taguchi, Ryosuke; Ueno, Shohei; Kawano, Takahito; Murata, Masaharu; Baba, Eishi; Akashi, Koichi

    CANCER LETTERS   532   215597   2022.4   ISSN:0304-3835 eISSN:1872-7980

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Cancer Letters  

    Cancer-associated fibroblasts (CAFs) play an important role in cancer progression. However, the origin of CAFs remains unclear. This study shows that macrophages in malignant ascites and pleural effusions (cavity fluid-associated macrophages: CAMs) transdifferentiate into fibroblast-like cells. CAMs obtained from gastrointestinal cancer patients were sorted by flow cytometry and cultured in vitro. CD45<sup>+</sup>CD14<sup>+</sup> CAMs transdifferentiated into CD45<sup>−</sup>CD90<sup>+</sup> fibroblast-like cells that exhibited spindle shapes. Then, cDNA microarray analysis showed that the CD45<sup>−</sup>CD90<sup>+</sup> fibroblast-like cells (macrophage-derived CAFs: MDCAFs) had a fibroblast-specific gene expression signature and produced growth factors for epithelial cell proliferation. Human colon cancer cells transplanted into immunodeficient mice with MDCAFs formed larger tumors than cancer cells alone. Gene ontology analyses showed the involvement of TGFβ signaling and cell-matrix adhesion in MDCAFs, and transdifferentiation of CAMs into MDCAFs was canceled by inhibiting TGFβ and cell adhesion. Furthermore, the acquired genetic alterations in hematopoietic stem cells (HSCs) were shared in CAMs and MDCAFs. Taken together, CAMs could be a source of CAFs and might originate from HSCs. We propose the transdifferentiation process of CAMs into MDCAFs as a new therapeutic target for fibrosis associated with gastrointestinal cancer.

    DOI: 10.1016/j.canlet.2022.215597

    Web of Science

    Scopus

    PubMed

  • Targeting leukemia-specific dependence on the de novo purine synthesis pathway Invited Reviewed International journal

    Yamauchi, Takuji; Miyawaki, Kohta; Semba, Yuichiro; Takahashi, Masatomo; Izumi, Yoshihiro; Nogami, Jumpei; Nakao, Fumihiko; Sugio, Takeshi; Sasaki, Kensuke; Pinello, Luca; Bauer, Daniel E.; Bamba, Takeshi; Akashi, Koichi; Maeda, Takahiro

    LEUKEMIA   36 ( 2 )   383 - 393   2022.2   ISSN:0887-6924 eISSN:1476-5551

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Leukemia  

    Acute myeloid leukemia (AML) is a devastating disease, and clinical outcomes are still far from satisfactory. Here, to identify novel targets for AML therapy, we performed a genome-wide CRISPR/Cas9 screen using AML cell lines, followed by a second screen in vivo. We show that PAICS, an enzyme involved in de novo purine biosynthesis, is a potential target for AML therapy. AML cells expressing shRNA-PAICS exhibited a proliferative disadvantage, indicating a toxic effect of shRNA-PAICS. Treatment of human AML cells with a PAICS inhibitor suppressed their proliferation by inhibiting DNA synthesis and promoting apoptosis and had anti-leukemic effects in AML PDX models. Furthermore, CRISPR/Cas9 screens using AML cells in the presence of the inhibitor revealed genes mediating resistance or synthetic lethal to PAICS inhibition. Our findings identify PAICS as a novel therapeutic target for AML and further define components of de novo purine synthesis pathway and its downstream effectors essential for AML cell survival.

    DOI: 10.1038/s41375-021-01369-0

    Web of Science

    Scopus

    PubMed

  • Lymphoma Microenvironment in DLBCL and PTCL-NOS: the key to uncovering heterogeneity and the potential for stratification

    Miyawaki Kohta, Sugio Takeshi

    Journal of Clinical and Experimental Hematopathology   62 ( 3 )   127 - 135   2022   ISSN:13464280 eISSN:18809952

     More details

    Language:English   Publisher:Japanese Society of Lymphoma Research  

    <p>Diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) are the most common subtypes of mature B cell neoplasm and T/NK cell lymphoma, respectively. They share a commonality in that they are, by definition, highly heterogeneous populations. Recent studies are revealing more about the heterogeneity of these diseases, and at the same time, there is an active debate on how to stratify these heterogeneous diseases and make them useful in clinical practice. The various immune cells and non-cellular components surrounding lymphoma cells, i.e., the lymphoma microenvironment, have been the subject of intense research since the late 2000s, and much knowledge has been accumulated over the past decade. As a result, it has become clear that the lymphoma microenvironment, despite its paucity in tissues, significantly impacts the lymphoma pathogenesis and clinical behavior, such as its prognosis and response to therapy. In this article, we review the role of the lymphoma microenvironment in DLBCL and PTCL-NOS, with particular attention given to its impact on the prognosis and stratification.</p>

    DOI: 10.3960/jslrt.22027

    Web of Science

    Scopus

    PubMed

    CiNii Research

  • Ustekinumab Improves Active Crohn's Disease by Suppressing the T Helper 17 Pathway Invited Reviewed International journal

    Ihara, Yutaro; Torisu, Takehiro; Miyawaki, Kohta; Umeno, Junji; Kawasaki, Keisuke; Hirano, Atsushi; Fujioka, Shin; Fuyuno, Yuta; Matsuno, Yuichi; Sugio, Takeshi; Sasaki, Kensuke; Moriyama, Tomohiko; Akashi, Koichi; Kitazono, Takanari

    DIGESTION   102 ( 6 )   946 - 955   2021.11

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000518103

  • Anti-GPRC5D/CD3 T cell-redirecting bispecific antibody with potent in vitro and in vivo antitumor efficacy against multiple myeloma. Invited Reviewed International journal

    Kodama, Tatsushi; Kochi, Yu; Nakai, Waka; Mizuno, Hideaki; Baba, Takeshi; Habu, Kiyoshi; Sawada, Noriaki; Tsunoda, Hiroyuki; Shima, Takahiro; Miyawaki, Kohta; Kikushige, Yoshikane; Mori, Yasuo; Miyamoto, Toshihiro; Maeda, Takahiro; Akashi, Koichi

    CANCER RESEARCH   81 ( 13 )   2021.7

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Long-term follow-up results of a phase II study of dose-adjusted (DA)-EPOCH-R with high-dose methotrexate (HD-MTX) for newly diagnosed stage IIIV CD5-positive diffuse large B-cell lymphoma (CD5+DLBCL). Invited Reviewed International journal

    Miyazaki, Kana; Sakai, Rika; Iwaki, Noriko; Yamamoto, Go; Yamada, Tomomi; Nishimura, Yuki; Tamaru, Satoshi; Asano, Naoko; Miyawaki, Kohta; Izutsu, Koji; Kinoshita, Tomohiro; Suzuki, Ritsuro; Ohshima, Koichi; Kato, Koji; Katayama, Naoyuki; Yamaguchi, Motoko

    JOURNAL OF CLINICAL ONCOLOGY   39 ( 15 )   2021.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.2021.39.15_suppl.7551

  • Autoimmune manifestations associated with myelodysplastic syndrome predict a poor prognosis Invited Reviewed International journal

    Arinobu, Yojiro; Kashiwado, Yusuke; Miyawaki, Kohta; Ayano, Masahiro; Kimoto, Yasutaka; Mitoma, Hiroki; Akahoshi, Mitsuteru; Miyamoto, Toshihiro; Horiuchi, Takahiko; Akashi, Koichi; Niiro, Hiroaki

    MEDICINE   100 ( 13 )   2021.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000025406

  • Type 1 helper T cells generate CXCL9/10-producing T-bet(+) effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Invited Reviewed International journal

    Nakayama, Tsuyoshi; Yoshimura, Motoki; Higashioka, Kazuhiko; Miyawaki, Kohta; Ota, Yuri; Ayano, Masahiro; Kimoto, Yasutaka; Mitoma, Hiroki; Ono, Nobuyuki; Arinobu, Yojiro; Kikukawa, Makoto; Yamada, Hisakata; Akashi, Koichi; Horiuchi, Takahiko; Niiro, Hiroaki

    CELLULAR IMMUNOLOGY   360   2021.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cellimm.2020.104263

  • Identification of RHAMM positive proliferative subpopulation within colorectal cancer stem cells Invited Reviewed International journal

    Nakano, Michitaka; Kikushige, Yoshikane; Miyawaki, Kohta; Mizuno, Shinichi; Tsuruta, Nobuhiro; Hanamura, Fumiyasu; Yamaguchi, Kyoko; Yamauchi, Takuji; Isobe, Taichi; Ariyama, Hiroshi; Kusaba, Hitoshi; Nakamura, Masafumi; Maeda, Takahiro; Baba, Eishi; Akashi, Koichi

    CANCER SCIENCE   112   165 - 165   2021.2

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma. Reviewed

    Torisu T, Kawano S, Miyawaki K, Yamamoto H, Ihara Y, Matsuno Y, Torisu K, Sugio T, Sasaki K, Shimakawa T, Kato K, Akashi K, Nakamura S, Kitazono T

    Hematol Oncol   39 ( 1 )   145 - 147   2021

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hon.2816

  • A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells. Reviewed

    Jinnouchi F, Yamauchi T, Yurino A, Nunomura T, Nakano M, Iwamoto C, Obara T, Miyawaki K, Kikushige Y, Kato K, Maeda T, Miyamoto T, Baba E, Akashi K, Takenaka K

    Blood   135 ( 19 )   1661 - 1672   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood.2019002194

  • DA-EPOCH-R combined with high-dose methotrexate in patients with newly diagnosed stage II-IV CD5-positive diffuse large B-cell lymphoma: a single-arm, open-label, phase II study. Reviewed

    Miyazaki K, Asano N, Yamada T, Miyawaki K, Sakai R, Igarashi T, Nishikori M, Ohata K, Sunami K, Yoshida I, Yamamoto G, Takahashi N, Okamoto M, Yano H, Nishimura Y, Tamaru S, Nishikawa M, Izutsu K, Kinoshita T, Suzumiya J, Ohshima K, Kato K, Katayama N, Yamaguchi M

    Haematologica   105 ( 9 )   2308 - 2315   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3324/haematol.2019.231076

  • Combination of CD47 and signal-regulatory protein-α constituting the "don't eat me signal" is a prognostic factor in diffuse large B-cell lymphoma. Reviewed

    Kazama R, Miyoshi H, Takeuchi M, Miyawaki K, Nakashima K, Yoshida N, Kawamoto K, Yanagida E, Yamada K, Umeno T, Suzuki T, Kato K, Takizawa J, Seto M, Akashi K, Ohshima K

    Cancer Sci   111 ( 7 )   2608 - 2619   2020

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14437

  • Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. Reviewed

    Mori Y, Yoshimoto G, Yuda JI, Hayashi M, Odawara J, Kuriyama T, Sugio T, Miyawaki K, Kamezaki K, Kato K, Takenaka K, Iwasaki H, Maeda T, Miyamoto T, Akashi K

    Leuk Lymphoma   60 ( 1 )   271 - 273   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/10428194.2018.1466295

  • CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines. Reviewed

    Takaki-Kuwahara A, Arinobu Y, Miyawaki K, Yamada H, Tsuzuki H, Irino K, Ayano M, Kimoto Y, Mitoma H, Akahoshi M, Tsukamoto H, Horiuchi T, Niiro H, Akashi K

    Arthritis Res Ther   21 ( 1 )   198   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-019-1984-x

  • Anti-GPRC5D/CD3 Bispecific T-Cell-Redirecting Antibody for the Treatment of Multiple Myeloma. Reviewed

    Kodama T, Kochi Y, Nakai W, Mizuno H, Baba T, Habu K, Sawada N, Tsunoda H, Shima T, Miyawaki K, Kikushige Y, Mori Y, Miyamoto T, Maeda T, Akashi K

    Mol Cancer Ther   18 ( 9 )   1555 - 1564   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1535-7163.MCT-18-1216

  • Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma. Reviewed

    Shimono J, Miyoshi H, Arakawa F, Yamada K, Sugio T, Miyawaki K, Eto T, Miyagishima T, Kato K, Nagafuji K, Akashi K, Teshima T, Ohshima K

    Ann Hematol   98 ( 5 )   1197 - 1207   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-019-03628-8

  • Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer. Reviewed

    Nakano M, Kikushige Y, Miyawaki K, Kunisaki Y, Mizuno S, Takenaka K, Tamura S, Okumura Y, Ito M, Ariyama H, Kusaba H, Nakamura M, Maeda T, Baba E, Akashi K

    Oncogene   38 ( 6 )   780 - 793   2019

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41388-018-0480-0

  • Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets. Reviewed

    Karube K, Enjuanes A, Dlouhy I, Jares P, Martin-Garcia D, Nadeu F, Ordóñez GR, Rovira J, Clot G, Royo C, Navarro A, Gonzalez-Farre B, Vaghefi A, Castellano G, Rubio-Perez C, Tamborero D, Briones J, Salar A, Sancho JM, Mercadal S, Gonzalez-Barca E, Escoda L, Miyoshi H, Ohshima K, Miyawaki K, Kato K, Akashi K, Mozos A, Colomo L, Alcoceba M, Valera A, Carrió A, Costa D, Lopez-Bigas N, Schmitz R, Staudt LM, Salaverria I, López-Guillermo A, Campo E

    Leukemia   32 ( 3 )   675 - 684   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/leu.2017.251

  • Analysis of GNA13 Protein in Follicular Lymphoma and its Association With Poor Prognosis. Reviewed

    Shimono J, Miyoshi H, Yoshida N, Kato T, Sato K, Sugio T, Miyawaki K, Kurita D, Sasaki Y, Kawamoto K, Imaizumi Y, Kato K, Nagafuji K, Akashi K, Seto M, Teshima T, Ohshima K

    Am J Surg Pathol   42 ( 11 )   1466 - 1471   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/PAS.0000000000000969

  • Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS. Reviewed

    Sugio T, Miyawaki K, Kato K, Sasaki K, Yamada K, Iqbal J, Miyamoto T, Ohshima K, Maeda T, Miyoshi H, Akashi K

    Blood Adv   2 ( 17 )   2242 - 2252   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/bloodadvances.2018018754

  • Epithelial-mesenchymal transition is activated in CD44-positive malignant ascites tumor cells of gastrointestinal cancer. Reviewed

    Nakano M, Ito M, Tanaka R, Ariyama H, Mitsugi K, Makiyama A, Uchino K, Esaki T, Tsuruta N, Hanamura F, Yamaguchi K, Okumura Y, Sagara K, Takayoshi K, Nio K, Tsuchihashi K, Tamura S, Shimokawa H, Arita S, Miyawaki K, Kusaba H, Akashi K, Baba E

    Cancer Sci   109 ( 11 )   3461 - 3470   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13777

  • Human Herpes Virus-6-Associated Encephalitis/Myelitis Mimicking Calcineurin Inhibitor-Induced Pain Syndrome in Allogeneic Stem Cell Transplantation Recipients. Reviewed

    Yoshimoto G, Mori Y, Kato K, Shima T, Miyawaki K, Kikushige Y, Kamezaki K, Numata A, Maeda T, Takenaka K, Iwasaki H, Teshima T, Akashi K, Miyamoto T

    Biol Blood Marrow Transplant   24 ( 12 )   2540 - 2548   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2018.07.017

  • Gastrointestinal Graft-versus-Host Disease Is a Risk Factor for Postengraftment Bloodstream Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients. Reviewed

    Mori Y, Yoshimoto G, Nishida R, Sugio T, Miyawaki K, Shima T, Nagasaki Y, Miyake N, Harada Y, Kunisaki Y, Kamezaki K, Numata A, Kato K, Shiratsuchi M, Maeda T, Takenaka K, Iwasaki H, Shimono N, Akashi K, Miyamoto T

    Biol Blood Marrow Transplant   24 ( 11 )   2302 - 2309   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2018.06.002

  • Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma. Reviewed

    Shimono J, Miyoshi H, Kato T, Sugio T, Miyawaki K, Kamimura T, Miyagishima T, Eto T, Imaizumi Y, Kato K, Nagafuji K, Akashi K, Seto M, Teshima T, Ohshima K

    Oncotarget   9 ( 2 )   1717 - 1725   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.23138

  • Expression of PD-1 and PD-L1 on cytotoxic T lymphocytes and immune deficiency in a patient with adult T cell leukemia/lymphoma. Reviewed

    Yanagihara T, Ikematsu Y, Kato K, Yonekawa A, Ideishi S, Tochigi T, Sugio T, Miyawaki K, Tanaka K, Harada E, Hamada N, Nakanishi Y

    Ann Hematol   97 ( 2 )   359 - 360   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-017-3146-z

  • Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes. Reviewed

    Tsuzuki H, Arinobu Y, Miyawaki K, Takaki A, Ota SI, Ota Y, Mitoma H, Akahoshi M, Mori Y, Iwasaki H, Niiro H, Tsukamoto H, Akashi K

    Immunology   150 ( 1 )   64 - 73   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/imm.12667

  • Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer. Reviewed

    Hidaka N, Iwama E, Kubo N, Harada T, Miyawaki K, Tanaka K, Okamoto I, Baba E, Akashi K, Sasaki H, Nakanishi Y

    Lung Cancer   108   75 - 82   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2017.02.019

  • Identification of unipotent megakaryocyte progenitors in human hematopoiesis. Reviewed

    Miyawaki K, Iwasaki H, Jiromaru T, Kusumoto H, Yurino A, Sugio T, Uehara Y, Odawara J, Daitoku S, Kunisaki Y, Mori Y, Arinobu Y, Tsuzuki H, Kikushige Y, Iino T, Kato K, Takenaka K, Miyamoto T, Maeda T, Akashi K

    Blood   129 ( 25 )   3332 - 3343   2017

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2016-09-741611

  • Graft-versus-host disease targets ovary and causes female infertility in mice. Reviewed

    Shimoji S, Hashimoto D, Tsujigiwa H, Miyawaki K, Kato K, Takahashi S, Ogasawara R, Jiromaru T, Iwasaki H, Miyamoto T, Akashi K, Teshima T

    Blood   129 ( 9 )   1216 - 1225   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2016-07-728337

  • Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease. Reviewed

    Sugio T, Kato K, Aoki T, Ohta T, Saito N, Yoshida S, Kawano I, Henzan H, Kadowaki M, Takase K, Muta T, Miyawaki K, Yamauchi T, Shima T, Takashima S, Mori Y, Yoshimoto G, Kamezaki K, Takenaka K, Iwasaki H, Ogawa R, Ohno Y, Eto T, Kamimura T, Miyamoto T, Akashi K

    Biol Blood Marrow Transplant   22 ( 9 )   1608 - 1614   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2016.05.017

  • Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations. Reviewed

    Yurino A, Takenaka K, Yamauchi T, Nunomura T, Uehara Y, Jinnouchi F, Miyawaki K, Kikushige Y, Kato K, Miyamoto T, Iwasaki H, Kunisaki Y, Akashi K

    Stem Cell Reports   7 ( 3 )   425 - 438   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stemcr.2016.07.002

  • CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor. Reviewed

    Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K

    Stem Cells   33 ( 3 )   976 - 987   2015

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/stem.1906

  • A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression. Reviewed

    Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K

    Cell Stem Cell   17 ( 3 )   341 - 352   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stem.2015.07.011

  • M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. Reviewed

    Zhou Y, Yoshida S, Nakao S, Yoshimura T, Kobayashi Y, Nakama T, Kubo Y, Miyawaki K, Yamaguchi M, Ishikawa K, Oshima Y, Akashi K, Ishibashi T

    Invest Ophthalmol Vis Sci   56 ( 8 )   4767 - 4777   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.14-16012

  • Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy. Reviewed

    Nobutani K, Shimono Y, Mizutani K, Ueda Y, Suzuki T, Kitayama M, Minami A, Momose K, Miyawaki K, Akashi K, Azuma T, Takai Y

    PLoS One   10 ( 6 )   e0130032   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0130032

  • Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo. Reviewed

    Fukata M, Ishikawa F, Najima Y, Yamauchi T, Saito Y, Takenaka K, Miyawaki K, Shimazu H, Shimoda K, Kanemaru T, Nakamura K, Odashiro K, Nagafuji K, Harada M, Akashi K

    PLoS One   8 ( 5 )   e62506   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0062506

  • Diagnostic value of serum procalcitonin and C-reactive protein for infections after allogeneic hematopoietic stem cell transplantation versus nontransplant setting. Reviewed

    Mori Y, Miyawaki K, Kato K, Takenaka K, Iwasaki H, Harada N, Miyamoto T, Akashi K, Teshima T

    Intern Med   50 ( 19 )   2149 - 2155   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.50.5798

  • [Clinical profiles of 7 patients with chronic myelogenous leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib]. Reviewed

    Hoshino T, Tahara K, Miyawaki K, Hatsumi N, Takada S, Miyawaki S, Sakura T

    Rinsho Ketsueki   51 ( 3 )   181 - 188   2010

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Pulmonary nocardiosis developed in a hematopoietic stem cell transplant recipient with bronchiolitis obliterans. Reviewed

    Nishida R, Mori Y, Iwasaki H, Tokuyama T, Kamezaki K, Nagasaki Y, Oka H, Miyawaki K, Saito N, Takenaka K, Harada N, Miyamoto T, Teshima T, Akashi K

    Intern Med   49 ( 14 )   1441 - 1444   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.49.3658

▼display all

Presentations

▼display all

MISC

  • Picture in Clinical Hematology(No.172) 再発リンパ腫組織内のCAR-T細胞の姿を捉える

    瀧川 健, 宮脇 恒太, 谷口 志保, 福島 伯泰, 岩崎 健, 加藤 光次, 赤司 浩一

    臨床血液   66 ( 5 )   303 - 304   2025.5   ISSN:0485-1439

     More details

    Language:Japanese   Publisher:(一社)日本血液学会-東京事務局  

  • 潰瘍性大腸炎の治療標的としての結腸上皮細胞におけるフェロトーシス、に対する返信(Reply to "Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis")

    Yokote Akihito, Imazu Noriyuki, Umeno Junji, Kawasaki Keisuke, Fujioka Shin, Fuyuno Yuta, Matsuno Yuichi, Moriyama Tomohiko, Miyawaki Kohta, Akashi Koichi, Kitazono Takanari, Torisu Takehiro

    Journal of Gastroenterology   59 ( 1 )   77 - 78   2024.1   ISSN:0944-1174

     More details

    Language:English   Publisher:シュプリンガー・ジャパン(株)  

  • CD5陽性DLBCLを対象としたDA-EPOCH-Rと高用量MTXを併用した第II相試験による5年間の追跡調査(Five-year follow-up of a phase II study of DA-EPOCH-R with high-dose MTX in CD5-positive DLBCL)

    Miyazaki Kana, Sakai Rika, Iwaki Noriko, Yamamoto Go, Murayama Kayoko, Nishikori Momoko, Sunami Kazutaka, Yoshida Isao, Yano Hiroki, Takahashi Naoki, Okamoto Akinao, Munemoto Saori, Sawazaki Aiko, Suehiro Youko, Fukuhara Noriko, Wake Atsushi, Arai Ayako, Masaki Yasufumi, Toyama Kohtaro, Yokoyama Akihiro, Tsunemine Hiroko, Hasegawa Yuichi, Matsumoto Kenji, Yamada Tomomi, Nishimura Yuki, Tamaru Satoshi, Asano Naoko, Miyawaki Kohta, Izutsu Koji, Kinoshita Tomohiro, Suzuki Ritsuro, Ohshima Koichi, Kato Koji, Katayama Naoyuki, Yamaguchi Motoko

    Cancer Science   114 ( 6 )   2689 - 2691   2023.6   ISSN:1347-9032

     More details

    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

    未治療のCD5陽性びまん性大細胞型B細胞リンパ腫(DLBCL)を対象に、DA-EPOCH-R(用量調整エトポシド/ビンクリスチン/シクロホスファミド/ドキソルビシン/プレドニゾン+リツキシマブ)療法に高用量メトトレキサート(HD-MTX)を併用した、第2相試験を実施した。5年間にわたる追跡調査結果を解析したところ、追跡期間中央値6.0年で評価症例47例の5年無増悪生存率(PFS)と全生存率(OS)は、それぞれ72%および79%であった。なお、一次解析後には頸部リンパ節、ワルダイエル輪、鼻腔再発患者が各1例に認められ、CD5+ABC型DLBCL患者39例の5年PFSとOSは72%および74%で、5年間のCNS再発率は9%であった。だが、一次解析後のCNS再発イベントはみられず、グレード3以上の晩期毒性を生じた患者も0例で、追跡期間中に心血管イベントと白質脳症を発症した患者もみられなかった。なお、二次悪性腫瘍は6例に報告され、うち2例の大腸癌は内視鏡的切除で治療成功が得られていた。以上より、DA-EPOCH-R/HD-MTXの優れた有効性と安全性が、5年以上維持されていることが確認された。

  • DLBCLとPTCL-NOSにおけるリンパ腫の腫瘍内微小環境 腫瘍内不均一性の解明に向けての要点と階層化の可能性について(Lymphoma Microenvironment in DLBCL and PTCL-NOS: the key to uncovering heterogeneity and the potential for stratification)

    Miyawaki Kohta, Sugio Takeshi

    Journal of Clinical and Experimental Hematopathology   62 ( 3 )   127 - 135   2022.9   ISSN:1346-4280

     More details

    Language:English   Publisher:(一社)日本リンパ腫学会  

  • Lymphoma Microenvironment in DLBCL and PTCL-NOS: the key to uncovering heterogeneity and the potential for stratification Reviewed

    Kohta Miyawaki

    The Journal of Clinical and Experimental Hematopathology   2022.8

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    Diffuse large B-cell lymphoma (DLBCL) and Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) are the most common subtypes of mature B cell neoplasm and T/NK cell lymphoma, respectively. They share a commonality in that they are, by definition, highly heterogeneous populations. Recent studies are revealing more about the heterogeneity of these diseases, and at the same time, there is an active debate on how to stratify these heterogeneous diseases and make them useful in clinical practice. The various immune cells and non-cellular components surrounding lymphoma cells, i.e., the lymphoma microenvironment, have been the subject of intense research since the late 2000s, and much knowledge has been accumulated over the past decade. As a result, it has become clear that the lymphoma microenvironment, despite its paucity in tissues, significantly impacts lymphoma pathogenesis and clinical behavior, such as prognosis and response to therapy. In this article, we review the role of the lymphoma microenvironment in DLBCL and PTCL-NOS, with particular attention to its impact on prognosis and stratification.

Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Japanese Society for Lymphoreticular Tissue Research

  • 日本造血・免疫細胞療法学会

  • 日本血液学会

  • 日本内科学会

Committee Memberships

  • 日本血液学会   ゲノム検査ガイドライン データベースキュレーター  

       

  • 日本血液学会   プログラム編成委員  

       

Research Projects

  • Comprehensive analysis of the tumor ecosystem in non-clear cell renal cell carcinoma using spatial omics approaches

    Grant number:23K24474  2024.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Baba Masaya

      More details

    Grant type:Scientific research funding

    We comprehensively analyzed the tumor ecosystem, including cell-cell interactions and tumor cell heterogeneity, in TFE3-rearranged renal cell carcinoma (TFE3-RCC), a subtype of non-clear cell renal cell carcinoma (nccRCC) associated with poor prognosis and lacking established treatments, using spatial transcriptomics and proteomics. Using cultured cells and genetically engineered mouse models, we revealed a novel molecular mechanism wherein fusion TFE3 activates the HIF1α-SREBP1 axis to enhance lipid metabolism and promote tumor growth. We further demonstrated that fusion TFE3 transcriptional activity depends on the CCNC/CDK8 complex, whose inhibition effectively suppressed TFE3-RCC proliferation, and clarified that ARID2 loss also promotes tumor malignancy.

    CiNii Research

  • 腸管GVHDの治療反応性を規定する局所免疫プロファイルの解明と腸内細菌叢の影響

    Grant number:23K07837  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    森 康雄, 宮脇 恒太

      More details

    Grant type:Scientific research funding

    移植片対宿主病 (Graft-versus-host disease: GVHD)は依然として問題となる造血細胞移植後の合併症であり、なかでもステロイド抵抗性の腸管GVHDは予後不良である。腸管GVHDの発症・重症化には、腸幹細胞のダメージや代謝障害に伴う腸管組織恒常性の破綻、腸内細菌叢の乱れなど複合的な要因が関わっていることが知られている。本研究では、GVHD組織内の局所免疫環境も治療反応性の規定因子であるという仮説のもと、診断時の腸管組織を用いた 遺伝子発現解析/多重免疫染色の結果とステロイド治療反応性、腸内細菌叢, 口腔内細菌叢の変化との相関を検証する。

    CiNii Research

  • ゲノム解析やオミクス解析データの蓄積から、がんにおける遺伝子変異やゲノム再構成が明らかにされてきた。一方で腫瘍組織はがん細胞だけではなく、線維芽細胞や間質、血管内皮細胞や壁細胞、腫瘍関連マクロファージやリンパ球をはじめとする免疫担当細胞等と共に極めて複雑な相互作用からなる腫瘍生態系(エコシステム)を形成しており、がん細胞単独のゲノム解析で発がんやがんの進展を理解するという従来の研究手法には限界がある。本研究では、転座腎細胞癌マウスモデル及びヒト臨床検体において、組織内の位置情報を保持したオミクス解析(空間的オミクス解析)を行う事で、腫瘍組織の複雑な細胞間相互作用ネットワークを紐解く。

    2022.4 - 2025.3

      More details

    Grant type:Other funds from industry-academia collaboration

  • びまん性大細胞型B細胞リンパ腫(DLBCL)は、最も頻度の高い悪性リンパ腫でありながら、約5割の患者が亡くなっており、これら難治性DLBCLの治療法開発は急務である。癌原遺伝子であるc-MYC(MYC)の過剰発現や変異を有するMYC関連DLBCLは、難治性DLBCLの多くを占めるが、MYC自体に対する創薬は困難とされている。そこで本研究では、大規模な臨床検体の解析を通じて、MYCの制御下においてDLBCLの増殖に不可欠な働きを有する代謝関連分子を同定し、難治性DLBCLに対する新たな標的治療の有効性、実現可能性を検証する。

    2021 - 2024

    Grants-in-Aid for Scientific Research (Ministry of Education, Culture, Sports, Science and Technology)

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • Development of Novel Therapeutic Targets for MYC-Related Refractory Diffuse Large B-Cell Lymphoma

    Grant number:21K08429  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Miyawaki Kohta

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

    Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma, with a mortality rate of approximately 50%. Among these, MYC-related DLBCL is particularly difficult to treat. This study aimed to develop new therapeutic strategies for MYC-related DLBCL. Through comprehensive gene expression analysis of numerous patient samples, we identified metabolic-related molecules highly expressed in patients with poor clinical prognosis and found that their expression is regulated by MYC. Furthermore, we confirmed that targeting these molecules showed significant therapeutic effects in both in vitro and in vivo models. This study demonstrates the efficacy of a new targeted therapy for MYC-related DLBCL, providing a potential new treatment option for this challenging subtype.

    CiNii Research

  • DLBCLの周囲微小環境による予後決定メカニズムの解明と新規治療標的の探索

    2018 - 2020

    Japan Society for the Promotion of Science  Research Fellowships for Young Scientists

      More details

    Authorship:Principal investigator  Grant type:Joint research

  • 巨核球・血小板系造血の分化機構の解明(lncRNAに注目して)

    Grant number:16K19578  2016 - 2017

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Educational Activities

  • ・医学部学生(ベッドサイド実習)に対する指導・講義
    ・医学部学生(基礎配置)に対する指導・講義

Class subject

  • 血液・免疫

Teaching Student Awards

  • プレナリーセッション

    Year and month of award:2025.3

    Classification of award-winning students:Doctoral student   Name of award-winning student:瀧川健

      More details

    CAR-T細胞療法・ICANS研究

Media Coverage

  • 気鋭の群像 (Young Japanese Hematologist) にて特集記事。 https://hematopaseo.jp/younghematologist/17_miyawaki_01/ https://hematopaseo.jp/younghematologist/17_miyawaki_02/ https://hematopaseo.jp/younghematologist/17_miyawaki_03/ Newspaper, magazine

    Hematopaseo  2021.7

     More details

    気鋭の群像 (Young Japanese Hematologist) にて特集記事。
    https://hematopaseo.jp/younghematologist/17_miyawaki_01/
    https://hematopaseo.jp/younghematologist/17_miyawaki_02/
    https://hematopaseo.jp/younghematologist/17_miyawaki_03/

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Hematology

Clinician qualification

  • Specialist

    The Japanese Society of Hematology

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 2006