MIYAWAKI KOHTA
Organization
Kyushu University Hospital Center for Cellular and Molecular Medicine Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
Tel
0926425947
Profile
Hematology Practice
Basic research related to hematopoietic malignancies
Homepage
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https://precision.kyushu-u.ac.jp/en/
Kyushu University School of Medicine Division of Precision Medicine
Degree
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Ph.D.
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M.D.
Research Interests・Research Keywords
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Research theme：Pathophysiology of hematopoietic tumors
Keyword：hematologic malignancies, lymphoma, leukemia
Research period： 2021.4 - 2022.7
Papers
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Prognostic value of pre-transplantation total metabolic tumor volume on (18)fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography in relapsed and refractory aggressive lymphoma Invited Reviewed International journal
Sugio, Takeshi; Baba, Shingo; Mori, Yasuo; Yoshimoto, Goichi; Kamesaki, Kenjiro; Takashima, Shuichiro; Urata, Shingo; Shima, Takahiro; Miyawaki, Kohta; Kikushige, Yoshikane; Kunisaki, Yuya; Numata, Akihiko; Takenaka, Katsuto; Iawasaki, Hiromi; Miyamoto, Toshihiro; Ishigami, Kousei; Akashi, Koichi; Kato, Koji
INTERNATIONAL JOURNAL OF HEMATOLOGY 2022.6
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A germinal center-associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL Invited Reviewed International journal
Miyawaki, Kohta; Kato, Koji; Sugio, Takeshi; Sasaki, Kensuke; Miyoshi, Hiroaki; Semba, Yuichiro; Kikushige, Yoshikane; Mori, Yasuo; Kunisaki, Yuya; Iwasaki, Hiromi; Miyamoto, Toshihiro; Kuo, Frank C.; Aster, Jon C.; Ohshima, Koichi; Maeda, Takahiro; Akashi, Koichi
BLOOD ADVANCES 6 ( 7 ) 2388 - 2402 2022.4
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Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions Invited Reviewed International journal
Ito, Mamoru; Nakano, Michitaka; Ariyama, Hiroshi; Yamaguchi, Kyoko; Tanaka, Risa; Semba, Yuichiro; Sugio, Takeshi; Miyawaki, Kohta; Kikushige, Yoshikane; Mizuno, Shinichi; Isobe, Taichi; Tanoue, Kenro; Taguchi, Ryosuke; Ueno, Shohei; Kawano, Takahito; Murata, Masaharu; Baba, Eishi; Akashi, Koichi
CANCER LETTERS 532 2022.4
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Targeting leukemia-specific dependence on the de novo purine synthesis pathway Invited Reviewed International journal
Yamauchi, Takuji; Miyawaki, Kohta; Semba, Yuichiro; Takahashi, Masatomo; Izumi, Yoshihiro; Nogami, Jumpei; Nakao, Fumihiko; Sugio, Takeshi; Sasaki, Kensuke; Pinello, Luca; Bauer, Daniel E.; Bamba, Takeshi; Akashi, Koichi; Maeda, Takahiro
LEUKEMIA 36 ( 2 ) 383 - 393 2022.2
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Ustekinumab Improves Active Crohn's Disease by Suppressing the T Helper 17 Pathway Invited Reviewed International journal
Ihara, Yutaro; Torisu, Takehiro; Miyawaki, Kohta; Umeno, Junji; Kawasaki, Keisuke; Hirano, Atsushi; Fujioka, Shin; Fuyuno, Yuta; Matsuno, Yuichi; Sugio, Takeshi; Sasaki, Kensuke; Moriyama, Tomohiko; Akashi, Koichi; Kitazono, Takanari
DIGESTION 102 ( 6 ) 946 - 955 2021.11
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Anti-GPRC5D/CD3 T cell-redirecting bispecific antibody with potent in vitro and in vivo antitumor efficacy against multiple myeloma. Invited Reviewed International journal
Kodama, Tatsushi; Kochi, Yu; Nakai, Waka; Mizuno, Hideaki; Baba, Takeshi; Habu, Kiyoshi; Sawada, Noriaki; Tsunoda, Hiroyuki; Shima, Takahiro; Miyawaki, Kohta; Kikushige, Yoshikane; Mori, Yasuo; Miyamoto, Toshihiro; Maeda, Takahiro; Akashi, Koichi
CANCER RESEARCH 81 ( 13 ) 2021.7
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Long-term follow-up results of a phase II study of dose-adjusted (DA)-EPOCH-R with high-dose methotrexate (HD-MTX) for newly diagnosed stage IIIV CD5-positive diffuse large B-cell lymphoma (CD5+DLBCL). Invited Reviewed International journal
Miyazaki, Kana; Sakai, Rika; Iwaki, Noriko; Yamamoto, Go; Yamada, Tomomi; Nishimura, Yuki; Tamaru, Satoshi; Asano, Naoko; Miyawaki, Kohta; Izutsu, Koji; Kinoshita, Tomohiro; Suzuki, Ritsuro; Ohshima, Koichi; Kato, Koji; Katayama, Naoyuki; Yamaguchi, Motoko
JOURNAL OF CLINICAL ONCOLOGY 39 ( 15 ) 2021.5
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Autoimmune manifestations associated with myelodysplastic syndrome predict a poor prognosis Invited Reviewed International journal
Arinobu, Yojiro; Kashiwado, Yusuke; Miyawaki, Kohta; Ayano, Masahiro; Kimoto, Yasutaka; Mitoma, Hiroki; Akahoshi, Mitsuteru; Miyamoto, Toshihiro; Horiuchi, Takahiko; Akashi, Koichi; Niiro, Hiroaki
MEDICINE 100 ( 13 ) 2021.4
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Type 1 helper T cells generate CXCL9/10-producing T-bet(+) effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Invited Reviewed International journal
Nakayama, Tsuyoshi; Yoshimura, Motoki; Higashioka, Kazuhiko; Miyawaki, Kohta; Ota, Yuri; Ayano, Masahiro; Kimoto, Yasutaka; Mitoma, Hiroki; Ono, Nobuyuki; Arinobu, Yojiro; Kikukawa, Makoto; Yamada, Hisakata; Akashi, Koichi; Horiuchi, Takahiko; Niiro, Hiroaki
CELLULAR IMMUNOLOGY 360 2021.2
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Identification of RHAMM positive proliferative subpopulation within colorectal cancer stem cells Invited Reviewed International journal
Nakano, Michitaka; Kikushige, Yoshikane; Miyawaki, Kohta; Mizuno, Shinichi; Tsuruta, Nobuhiro; Hanamura, Fumiyasu; Yamaguchi, Kyoko; Yamauchi, Takuji; Isobe, Taichi; Ariyama, Hiroshi; Kusaba, Hitoshi; Nakamura, Masafumi; Maeda, Takahiro; Baba, Eishi; Akashi, Koichi
CANCER SCIENCE 112 165 - 165 2021.2
Presentations
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「病理診断とゲノム診断の融合 ーリンパ腫診断のパラダイムシフト−」 リンパ系腫瘍におけるゲノム異常の総論 Invited
宮脇恒太
第62回日本リンパ網内系学会学術集会・総会／第25回日本血液病理研究会 2022.6
MISC
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Lymphoma Microenvironment in DLBCL and PTCL-NOS: the key to uncovering heterogeneity and the potential for stratification Reviewed
Kohta Miyawaki
The Journal of Clinical and Experimental Hematopathology 2022.8
Industrial property rights
| Patent | Number of applications: 1 | Number of registrations: 0 |
| Utility model | Number of applications: 0 | Number of registrations: 0 |
| Design | Number of applications: 0 | Number of registrations: 0 |
| Trademark | Number of applications: 0 | Number of registrations: 0 |
Professional Memberships
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The Japanese Society for Lymphoreticular Tissue Research
Research Projects
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ゲノム解析やオミクス解析データの蓄積から、がんにおける遺伝子変異やゲノム再構成が明らかにされてきた。一方で腫瘍組織はがん細胞だけではなく、線維芽細胞や間質、血管内皮細胞や壁細胞、腫瘍関連マクロファージやリンパ球をはじめとする免疫担当細胞等と共に極めて複雑な相互作用からなる腫瘍生態系（エコシステム）を形成しており、がん細胞単独のゲノム解析で発がんやがんの進展を理解するという従来の研究手法には限界がある。本研究では、転座腎細胞癌マウスモデル及びヒト臨床検体において、組織内の位置情報を保持したオミクス解析（空間的オミクス解析）を行う事で、腫瘍組織の複雑な細胞間相互作用ネットワークを紐解く。
2022.4 - 2025.3
Grant type：Other funds from industry-academia collaboration
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びまん性大細胞型B細胞リンパ腫（DLBCL）は、最も頻度の高い悪性リンパ腫でありながら、約5割の患者が亡くなっており、これら難治性DLBCLの治療法開発は急務である。癌原遺伝子であるc-MYC（MYC）の過剰発現や変異を有するMYC関連DLBCLは、難治性DLBCLの多くを占めるが、MYC自体に対する創薬は困難とされている。そこで本研究では、大規模な臨床検体の解析を通じて、MYCの制御下においてDLBCLの増殖に不可欠な働きを有する代謝関連分子を同定し、難治性DLBCLに対する新たな標的治療の有効性、実現可能性を検証する。
2021 - 2024
科学研究費補助金 (文部科学省）
Authorship：Principal investigator Grant type：Contract research
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MYC関連難治性びまん性大細胞型B細胞リンパ腫に対する新規治療標的の開発
Grant number：21K08429 2021 - 2023
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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DLBCLの周囲微小環境による予後決定メカニズムの解明と新規治療標的の探索
2018 - 2020
日本学術振興会 特別研究員
Authorship：Principal investigator Grant type：Joint research
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巨核球・血小板系造血の分化機構の解明（lncRNAに注目して）
Grant number：16K19578 2016 - 2017
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
Media Coverage
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気鋭の群像 (Young Japanese Hematologist) にて特集記事。 https://hematopaseo.jp/younghematologist/17_miyawaki_01/ https://hematopaseo.jp/younghematologist/17_miyawaki_02/ https://hematopaseo.jp/younghematologist/17_miyawaki_0３/ Newspaper, magazine
2021.7
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Hematology
Clinician qualification
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Specialist
The Japanese Society of Hematology
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Certifying physician
The Japanese Society of Internal Medicine（JSIM）
Year of medical license acquisition
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2006