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写真a

ジンノ ヨウヘイ
神野 洋平
JINNO YOHEI
所属
九州大学病院 義歯補綴科 講師
歯学部 歯学科(併任)
歯学府 歯学専攻(併任)
職名
講師
電話番号
0926426441
プロフィール
補綴歯科治療に関する研究、教育、臨床に携わっている。 研究に関しては、特に歯科インプラント 治療に関する研究を長年行っており、材料学的視点、生物学的視点の双方から歯科インプラント 治療の成功率のさらなる向上への貢献を目指している。 教育に関しては、大学院生に上記の研究について指導を行なっている。学部学生への臨床実習等での指導も行なっている。 特に歯科インプラント治療、顎補綴治療を専門としている。
外部リンク

研究分野

  • ライフサイエンス / 補綴系歯学

  • ライフサイエンス / 口腔再生医学、歯科医用工学

学位

  • 博士(歯学)

経歴

  • 九州大学 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴学分野 助教 

    2020年4月 - 現在

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    国名:日本国

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  • スウェーデン・マルメ大学 歯学部 補綴学教室・顎顔面口腔外科学教室   

研究テーマ・研究キーワード

  • 研究テーマ: 骨造成

    研究キーワード: 骨造成

    研究期間: 2024年

  • 研究テーマ: 歯科インプラント

    研究キーワード: 歯科インプラント

    研究期間: 2024年

  • 研究テーマ: PEEK材料の生体適合性向上に関する研究

    研究キーワード: PEEK

    研究期間: 2020年9月 - 2024年4月

  • 研究テーマ: エビデンスベースのインプラント埋入手術時の注意点

    研究キーワード: インプラント手術、 埋入トルク、 コンタミネーション

    研究期間: 2020年4月 - 2025年3月

  • 研究テーマ: 上顎洞底挙上術用のスポンジ状新規骨補填材の開発

    研究キーワード: PLLA PLGA 高分子 βTCP HA

    研究期間: 2011年8月 - 2013年3月

  • 研究テーマ: 新規ドラッグデリバリーシステムを用いた高脂血症治療薬スタチンによる骨増生

    研究キーワード: 骨補填材 スタチン 骨増生

    研究期間: 2011年2月 - 2013年1月

受賞

  • 学術研究賞

    2008年3月   九州大学学生後援会  

  • 課題口演優秀発表賞

    2007年9月   日本口腔インプラント学会  

  • 最優秀発表賞

    2007年9月   公益社団法人日本口腔インプラント学会  

論文

  • Synergistic Effect of Nano Strontium Titanate Coating and Ultraviolet C Photofunctionalization on Osteogenic Performance and Soft Tissue Sealing of poly(ether-ether-ketone)

    Chen, T; Jinno, Y; Atsuta, I; Tsuchiya, A; Obinata, S; Iimori, R; Kimura, T; Ayukawa, Y

    ACS BIOMATERIALS SCIENCE & ENGINEERING   10 ( 2 )   825 - 837   2024年1月   ISSN:2373-9878 eISSN:2373-9878

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACS Biomaterials Science and Engineering  

    This study aimed to evaluate the bioactivity of poly(ether ether ketone) (PEEK) after surface modification by persistent photoconductive strontium titanate (SrTiO3) magnetron sputtering and ultraviolet (UV) C irradiation. According to the different modifications, the PEEK specimens were randomly divided into five groups (n = 38/group): PEEK, Sr100-PEEK, Sr200-PEEK, UV/PEEK, and UV/Sr200-PEEK. Then, the specimens of Sr100-PEEK and Sr200-PEEK groups were, respectively, coated with 100 and 200 nm thickness photocatalyst SrTiO3 on the PEEK surface by magnetron sputtering. Subsequently, UV-C light photofunctionalized the specimens of PEEK and Sr200-PEEK groups to form UV/PEEK and UV/Sr200-PEEK groups. The specimens were characterized by a step meter, scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive X-ray spectroscopy (EDX), and a water contact angle meter. The release test of the Sr ion was performed by inductively coupled plasma mass spectrometry (ICP-MS). In vitro study, osteogenic activity (MC3T3-E1 osteoblast-like cells) and epithelial and connective tissue attachment (gingival epithelial cells GE1 and fibroblasts NIH3T3) were analyzed in five groups. Surface morphology of the specimens was changed after coating, and the Sr content on the Sr-PEEK surface was increased with increasing coating thickness. In addition, the contact angle was increased significantly after magnetron sputtering. After UV-C photofunctionalization, the content of surface elements changed and the contact angle was decreased. The release of Sr ion was sustained, and the final cumulative release amount did not exceed the safety limit. In vitro experiments showed that SrTiO3 improved the cell activity of MC3T3-E1 and UV-C irradiation further enhanced the osteogenic performance of PEEK. Besides, UV-C irradiation also significantly promoted the cell viability, development, and expression of adhesion proteins of GE1 and NIH3T3 on PEEK. The present investigation demonstrated that nano SrTiO3 coating with UV-C photofunctionalization synergistically enhanced the osteogenic properties and soft tissue sealing function of PEEK in vitro.

    DOI: 10.1021/acsbiomaterials.3c01684

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  • インプラント体周囲硬組織を理解し評価するために:臨床論文からみえてくるもの,基礎研究からわかること

    神野 洋平

    日本口腔インプラント学会誌   36 ( 4 )   218 - 223   2023年12月   ISSN:09146695 eISSN:21879117

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    記述言語:日本語   出版者・発行元:公益社団法人 日本口腔インプラント学会  

    <p>インプラント体周囲硬組織の評価は,治療計画の立案から経過観察に至るまでのすべてのタイミングにおいて治療の成功・失敗に直結する重要事項である.臨床現場における主な硬組織評価法はエックス線診断・埋入トルク値の計測・共振周波数解析であり,非常に有効な評価方法であることがすでに多くの基礎研究・臨床研究で示されている.さらなるインプラント治療の高い成功率の達成のためには,これらの硬組織評価方法では評価できない骨内変化を理解することが必要であると考えている.本論文では主に埋入術式の違い,荷重負荷の有無による骨内変化に焦点を当てて解説する.</p><p>研究データの積み重ねにより,解剖学的なリスクの回避,適切な部位への埋入といった従来の評価基準に加え,適切な埋入術式,適切な荷重負荷開始時期,さらには周囲骨吸収の予測などが術前に評価可能となるオーダーメイド型の硬組織評価法が構築されていくことを期待している.</p>

    DOI: 10.11237/jsoi.36.218

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  • Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review

    Chen T., Jinno Y., Atsuta I., Tsuchiya A., Stocchero M., Bressan E., Ayukawa Y.

    Journal of Prosthodontic Research   67 ( 3 )   337 - 347   2023年7月   ISSN:18831958 eISSN:2212-4632

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Prosthodontic Research  

    PURPOSE: The aim of this study was to review the literature on current surface modification strategies used to improve the binding efficiency of an emerging biological material, polyetheretherketone (PEEK), with bone and soft tissues. STUDY SELECTION: This review was based on articles retrieved from PubMed, Google Scholar, Web of Science, and ScienceDirect databases. The main keywords used during the search were "polyetheretherketone (PEEK)," "implant," "surface modification," "biomaterials," "bone," "osseointegration," and "soft tissue." RESULTS: The suitability of PEEK surface modification strategies has been critically analyzed and summarized here. Many cell and in vivo experiments in small animals have shown that the use of advanced modification technologies with appropriate surface modification strategies can effectively improve the surface inertness of PEEK, thereby improving its binding efficiency with bone and soft tissues. CONCLUSIONS: Surface modifications of PEEK have revealed new possibilities for implant treatment; however, most results are based on in vitro or short-term in vivo evaluations in small animals. To achieve a broad application of PEEK in the field of oral implantology, more in vivo experiments and long-term clinical evaluations are needed to investigate the effects of various surface modifications on the tissue integration ability of PEEK to develop an ideal implant material.

    DOI: 10.2186/jpr.JPR_D_22_00138

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  • Effect of Drilling Preparation on Immediately Loaded Implants: An In Vivo Study in Sheep

    Stocchero, M; Jinno, Y; Toia, M; Ahmad, M; Galli, S; Papia, E; Herath, M; Becktor, JP

    INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS   38 ( 3 )   607 - 618   2023年5月   ISSN:0882-2786 eISSN:1942-4434

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    出版者・発行元:International Journal of Oral and Maxillofacial Implants  

    Purpose: To determine the biologic and biomechanical effects of two implant drilling protocols on the cortical bone around implants subjected to immediate loading. Materials and Methods: A total of 48 implants were inserted into the mandibles of six sheep following one of two drilling protocols: undersized preparation (US; n = 24) and nonundersized preparation (NUS; n = 24). Immediately after implant insertion, an abutment was placed on each implant and 36 implants were subjected to 10 sessions of dynamic vertical loads (1,500 cycles, 1 Hz) of 25 N or 50 N. Insertion torque value (ITV) was recorded at implant installation. Resonance frequency analysis (RFA) was measured at implant insertion and at each loading session. Fluorochrome was administered at day 17, and the animals were euthanized after 5 weeks. The removal torque values (RTVs) were measured, and samples underwent histomorphometric, μCT (microcomputed tomography), and fluorescence image acquisition analyses. The bone volume density (BV/TV), bone-to-implant contact (BIC), bone area fraction occupancy (BAFO), and fluorochrome stained bone surface (MS) were calculated. A linear mixed model analysis was performed, and Pearson paired correlation was calculated. Results: Five implants from the NUS group failed, with a mean ITV of 8.8 Ncm and an RFA value of 57. The mean ITVs for US group and NUS group were 80.5 (± 14) Ncm and 45.9 (± 25) Ncm, respectively (P <.001). No differences were noted in the RFA values from the time of implant insertion until the end of the study. No differences in RTV, BV/TV, BAFO, or MS were observed between the groups. Intense new bone formation took place in the NUS group implants that were subjected to load. Conclusions: Undersized preparation of cortical bone ensured a greater BIC compared to a nonundersized preparation. Moreover, this study demonstrated that immediate loading did not interfere with the osseointegration process, but loading induced intense new bone formation in the NUS group. It is not recommended to immediately load the implants when the clinically perceived primary stability is lower than an ITV of 10 Ncm and an RFA value of 60. Int J Oral Maxillofac Implants 2023;38:607–618.

    DOI: 10.11607/jomi.9949

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  • Impact of salivary contamination during implant placement with different surface characteristics in native and augmented bone: An in vivo study in sheep calvaria model

    Jinno, Y; Stocchero, M; Toia, M; Papia, E; Ahmad, M; Becktor, JP

    CLINICAL ORAL IMPLANTS RESEARCH   34 ( 3 )   254 - 262   2023年1月   ISSN:0905-7161 eISSN:1600-0501

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    記述言語:その他   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Oral Implants Research  

    Objectives: The aim of this study was to evaluate whether salivary contamination during placement of implants with different surface characteristics affects osseointegration in native and in augmented bone areas. Materials and Methods: Forty eight implants with machined surface (MS) and 48 implants with moderately rough surface (RS) were tested in the calvaria of 12 sheep. At the first surgery, 64 bony critical defects were randomly created and were subsequently augmented with two materials (autogenous or bovine bone). After 5 weeks of graft healing, 8 implants were placed per sheep, in native bone and in the centre of the augmented defects. Forty eight implants were soaked with saliva before placement (contaminated group [CG]), while 48 implants were not (non-contaminated group [NCG]). Five weeks after implant placement, bone-to-implant contact (BIC) and bone material area fraction occupancy (BMAFO) were calculated histomorphometrically. Results: Saliva contamination showed a significant negative effect (p =.000) on BIC, especially in augmented areas. RS showed significant positive effect on BIC, compared to MS (p =.000), while there were no significant differences for different bone conditions (p =.103). For BMAFO, the contamination showed a significantly negative affect (p =.000), while there were no significant differences for surface characteristics (p =.322) and for bone condition (p =.538). Conclusion: Saliva contamination during dental implant placement has a negative effect on osseointegration in augmented areas. Moderately rough surface has a possible advantage in the aspect of initial bone to implant contact. However, it seems to be advisable to avoid saliva contamination especially for implants placed in augmented bone areas.

    DOI: 10.1111/clr.14038

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  • 骨密度の違いに基づき判定した、インプラント部位のドリルプレパレーションが通常の場合と少なめの場合で得られる臨床効果 系統的レビューとメタアナリシス(Clinical effects of conventional and underprepared drilling preparation of the implant site based on bone density: A systematic review and meta-regression)

    Antonacci Donato, Del Fabbro Massimo, Bollero Patrizio, Stocchero Michele, Jinno Yohei, Canullo Luigi

    Journal of Prosthodontic Research   67 ( 1 )   23 - 34   2023年1月   ISSN:1883-1958

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    記述言語:英語   出版者・発行元:(公社)日本補綴歯科学会  

    インプラント部位へドリルプレパレーション処置を行う場合、特に同部位の骨密度が低い症例では、プレパレーション寸法を小さめにとることがある(underpreparation;アンダー処置)。こうしたドリルプレパレーションのアンダー処置と通常の処置の違いが臨床成功率に及ぼす影響を、骨密度の点で区別しつつ調査する系統的レビューとメタアナリシスを施行した。3種のデータベースの全登録文献を対象に関連キーワードでの検索を行った。適格とする研究は、少なくとも症例10名の転帰を評価していたランダム化または非ランダム化での臨床試験、および後方視的コホート研究とした。最終的に14報をメタ回帰分析に組み入れた。算出された骨吸収量は、ドリルプレパレーションの通常処置群では平均-0.43±0.28mm、アンダー処置群では平均-0.80±0.37mmとなった。骨密度が高い群から低い群まで4群に分けてインプラント周囲骨レベル(MBL)を比較した本メタ回帰分析から、MBLはドリルプレパレーションの種類および骨密度によって影響されることが示された。特に骨密度が最も高い群では、アンダー処置群よりも通常処置群の方がMBLは低くなっていた。骨密度が最も低い群を除いた3群においては、骨削除部位に対しインプラントがより大きくミスマッチであることがMBL上昇と正に関連していた。

  • Clinical effects of conventional and underprepared drilling preparation of the implant site based on bone density: A systematic review and meta-regression

    Antonacci, D; Del Fabbro, M; Bollero, P; Stocchero, M; Jinno, Y; Canullo, L

    JOURNAL OF PROSTHODONTIC RESEARCH   67 ( 1 )   23 - 34   2023年   ISSN:18831958 eISSN:18839207

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:公益社団法人 日本補綴歯科学会  

    Purpose: There is no clinical consensus to determine the right balance between underpreparation and marginal bone level changes. The purpose of this systematic review and meta-regression was to investigate the influence of the type of drilling preparation of the implant site in relation to the bone mineral density on the clinical success, expressed in terms of the MBL and implant failure rate. Study Selection: A thorough search was performed using the digital databases MEDLINE PubMed, EMBASE, and Co-chrane Central Register of Controlled Trials by entering research lines or various combinations of free words. The main keywords used were “dental implants”, “bone density”, and “torque”. Results: The mean bone resorption in the conventional preparation group was-0.43 (± 0.28) mm, whereas it was-0.80 (± 0.37) mm in the underprepared group. For the D1/D2/D3 bone group, the slope was significantly different from zero and linearity; the D4 bone group slope was not significantly different from zero and was almost parallel, although it was significantly different from linearity. The box and whiskers plot shows that the MBL in underprepared sites tended to be significantly higher with a higher variation than that in conventionally prepared sites. Conclusions: Within its limits, our meta-regression analysis showed that MBL is influenced by the type of drilling preparation and bone mineral density. In particular, a lower MBL was observed in the D1 bone with conventional preparation than with underpreparation. Moreover, a greater implant-to-osteotomy site mismatch was positively associated with greater MBLs in the bone densities of D1/D2/D3.

    DOI: 10.2186/jpr.jpr_d_21_00275

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  • Synergistic Effect of Carbonate Apatite and Autogenous Bone on Osteogenesis 国際誌

    Atsuta, I; Mizokami, T; Jinno, Y; Ji, B; Xie, TY; Ayukawa, Y

    MATERIALS   15 ( 22 )   2022年11月   ISSN:1996-1944 eISSN:1996-1944

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Materials  

    Bone augmentation using artificial bone is an important option in dental defect prostheses. A bone substitute using carbonate apatite (CO3Ap), an inorganic component of bone, was reported to have promising bone formation and bone replacement ability. However, the osteoinductivity of artificial bone is less than autogenous bone (AB). In this study, CO3Ap with AB is demonstrated as a clinically effective bone substitute. For in vitro experiments, an osteoclast-like cell (RAW-D) was cultured in the presence of AB, CO3Ap, or both (Mix), and the number of osteoclasts was evaluated. Osteoblasts were also cultured under the same conditions, and the number of adherent cells was evaluated. For in vivo experiments, a few holes were created in the rat tibia and AB, CO3Ap, or Mix were added. At 0, 14, and 21 days, the tissue morphology of the wound area was observed, and the thickness of the cortical bone was measured. In vitro, Mix did not increase the number of osteoclasts or osteoblasts. However, in vivo, the rate of bone replacement remarkably increased with Mix on dome-shape. A bone-grafting material combining osteoinductive AB with abundant artificial bone is expected to be clinically easy to use and able to form bone.

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  • Localization of Integrin Beta-4 Subunit at Soft Tissue–Titanium or Zirconia Interface 国際誌

    Yasunori Ayukawa, Ikiru Atsuta, Yasuko Moriyama, Yohei Jinno, Kiyoshi Koyano

    Journal of Clinical Medicine   9 ( 10 )   3331 - 3331   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Currently, along with titanium (Ti), zirconia is widely used as an abutment material for dental implants because it makes it possible to avoid gingival discoloration; however, the epithelial sealing capability of zirconia remains unknown. The purpose of the present study is to elucidate the localization of integrin β4 subunit (Inβ4), one of the main proteins in the attachment structure between gingival junctional epithelial (JE) cells and substrata. Maxillary first molars were extracted from rats, and implants were placed with Ti or zirconia transgingival parts; then, the localization of Inβ4 was observed. Morphological and functional changes in rat oral epithelial cells (OECs) cultured on a culture dish (Dish) and Ti and zirconia plates were also evaluated with Inβ4 immunofluorescence histochemistry and Western blotting. After four weeks of implant placement, the morphology of the peri-implant epithelium (PIE) and the localization of Inβ4 around the Ti and zirconia transgingival parts were similar. However, both exhibited markedly shorter Inβ4-positive bands in the PIE than in the JE around natural teeth. Decreased expression levels of Inβ4 were observed in OECs cultured on Ti and zirconia plates compared with those cultured on Dish. In conclusion, although inferior to natural teeth, zirconia implants are thought to have epithelial sealing properties comparable to those of titanium.

    DOI: 10.3390/jcm9103331

  • Impact of a hydrophilic dental implant surface on osseointegration: biomechanical results in rabbit. 査読 国際誌

    Jinno Y, Stocchero M, Galli S, Toia M, Becktor JP

    The Journal of oral implantology   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study aimed to evaluate the effect of surface hydrophilicity on the biomechanical aspects of osseointegration of dental implants in the tibia and femur of rabbits. Forty-eight mature female New Zealand White rabbits were included, and 96 commercially pure, Grade 4, titanium dental implants (control group), and 96 implants of same macro geometry with the hydrophilic surface (test group) were used in this study. One osteotomy was performed in each tibia and femur on both sides of the rabbit, and four implants were placed in each rabbit. Control and test groups were randomly allocated on the left and right sides. During surgery, insertion torque (ITQ) value of the complete implant placement was recorded. After healing periods of 0, 2, 4, and 8 weeks after surgery, Implant Stability Quotient (ISQ) value, and removal torque (RTQ) values were measured. No statistical difference was observed for ITQ, for ISQ and for RTQ between the control group and test group in tibia/femur for all time periods. The effect of hydrophilic properties on moderately roughened surfaces has no impact in terms of biomechanical outcomes (ISQ values and RTQ values) after a healing period of 2 to 8 weeks in rabbit tibias /femurs.

    DOI: 10.1563/aaid-joi-d-19-00217

  • In silico multi-scale analysis of remodeling peri-implant cortical bone: a comparison of two types of bone structures following an undersized and non-undersized technique 査読 国際誌

    M. Stocchero, Y. Jinno, M. Toia, R. Jimbo, C. Lee, S. Yamaguchi, S. Imazato, J.P. Becktor

    Journal of the mechanical behavior of biomedical materials 103   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • In silico multi-scale analysis of remodeling peri-implant cortical bone: a comparison of two types of bone structures following an undersized and non-undersized technique. 査読 国際誌

    Stocchero M, Jinno Y, Toia M, Jimbo R, Lee C, Yamaguchi S, Imazato S, Becktor JP

    Journal of the mechanical behavior of biomedical materials   103   103598 - 103598   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The aim of this multi-scale in silico study was to evaluate the influence of resorption cavities on the mechanical properties and load distribution in cortical bone after implant placement with two different drilling protocols. MATERIAL AND METHODS: Two different micro-scale bone structures were assessed: cortical bone models with cavities (test) and without cavities (control) were designed from μCT data. In a macro-scale model, representing a mandibular ridge, oblique load of 150 N was applied on the implant-abutment. Maximum principal stress/strain, and shear stress/strain were calculated in the macro- and micro-scale models. RESULTS: Test presented anisotropic material properties. In tests, significantly greater maximum values of Maximum principal stress/strain were calculated in micro-scale model. These values were located at the implant neck area in the macro-scale model and in the proximity of cavities in the micro-scale model respectively. Greater values of shear stress/strain were found in the test along the mandibular horizontal plane. CONCLUSIONS: Cortical bone with resorption cavities following undersized drilling showed an impaired load distribution compared with bone without cavities. Subsequently, stress/strain distribution suggests that this bone model is more prone to microdamage, thus delaying the healing process.

    DOI: 10.1016/j.jmbbm.2019.103598

  • Impact of salivary contamination during placement of implants with simultaneous bony augmentation in iliac bone in sheep. 査読 国際誌

    Jinno Y, Johansson K, Stocchero M, Toia M, Galli S, Stavropoulos A, Becktor JP

    The British journal of oral & maxillofacial surgery   57 ( 10 )   1131 - 1136   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Our aim was to investigate the possible impact of contamination with saliva on osseointegration during placement of implants with simultaneous bone augmentation. Six hemispheric shape bone defects (8mm in diameter×4mm deep) were prepared in each iliac bone of six sheep. A dental implant (2.9mm in diameter×10mm long) was placed in the centre of each defect, and then pairs of defects were filled with one of the following bone augmentation materials: autogenous bone, autogenous bone plus bovine bone, or resorbable biphasic ceramic bone substitute. One site in each augmentation group was impregnated with saliva (contaminated group), while the other was not (non-contaminated group). Bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) within implant threads were measured after a healing period of five weeks, both in respect of the implant inserted in the augmented bone and in that inserted in the residual bone. Overall results showed that there was a significant difference between the contaminated and non-contaminated group for BIC in the augmented implant (p=0.028), while there were no significant differences in the implant in residual bone (p=0.722). For BAFO, there were no significant differences between the contaminated and non-contaminated groups among the different augmentation materials. The results showed that contamination with saliva during placement of an implant with simultaneous bone augmentation had a serious deleterious effect on osseointegration of the aspect of the implant within the augmented defect. Contamination with saliva during placement of an implant with simultaneous bone augmentation should therefore be avoided.

    DOI: 10.1016/j.bjoms.2019.10.302

  • Long Term Retention of Gingival Sealing around Titanium Implants with CaCl2 Hydrothermal Treatment: A Rodent Study. 査読 国際誌

    Ayukawa Y, Oshiro W, Atsuta I, Furuhashi A, Kondo R, Jinno Y, Koyano K

    Journal of clinical medicine   8 ( 10 )   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We previously reported that CaCl2 hydrothermal-treated (Ca-HT) titanium (Ti) implants induced a tight sealing at the interface between the implant and peri-implant epithelium (PIE) after implantation. However, it is not clear how long this improved epithelium sealing can be maintained. We subsequently investigated whether the positive effect of Ca-HT to promote sealing between the PIE and implant was sustained longer term. Maxillary molars were extracted from rats and replaced with either Ca-HT implants (Ca-HT group), distilled water-HT implants (DW-HT group) or non-treated implants (control group). After 16 weeks, the majority of implants in the Ca-HT group remained at the maxillary with no apical extension of the PIE. Conversely, half the number of control implants was lost following down-growth of the PIE. The effect of Ca-HT on migration and proliferation of rat oral epithelial cells (OECs) was also investigated. In OECs cultured on Ca-HT Ti plates, protein expression in relation to cell migration decreased, and proliferation was higher than other groups. Surface analysis indicated HT enhanced the formation of surface TiO2 layer without altering surface topography. Consequently, Ca-HT of Ti reduced PIE down-growth via tight epithelial attachment to the surface, which may enhance implant capability for a longer time post-implantation.

    DOI: 10.3390/jcm8101560

  • Intraosseous Temperature Change during Installation of Dental Implants with Two Different Surfaces and Different Drilling Protocols: An In Vivo Study in Sheep. 査読 国際誌

    Stocchero M, Jinno Y, Toia M, Ahmad M, Papia E, Yamaguchi S, Becktor JP

    Journal of clinical medicine   8 ( 8 )   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The intraosseous temperature during implant installation has never been evaluated in an in vivo controlled setup. The aims were to investigate the influence of a drilling protocol and implant surface on the intraosseous temperature during implant installation, to evaluate the influence of temperature increase on osseointegration and to calculate the heat distribution in cortical bone. METHODS: Forty Brånemark implants were installed into the metatarsal bone of Finnish Dorset crossbred sheep according to two different drilling protocols (undersized/non-undersized) and two surfaces (moderately rough/turned). The intraosseous temperature was recorded, and Finite Element Model (FEM) was generated to understand the thermal behavior. Non-decalcified histology was carried out after five weeks of healing. The following osseointegration parameters were calculated: Bone-to-implant contact (BIC), Bone Area Fraction Occupancy (BAFO), and Bone Area Fraction Occupancy up to 1.5 mm (BA1.5). A multiple regression model was used to identify the influencing variables on the histomorphometric parameters. RESULTS: The temperature was affected by the drilling protocol, while no influence was demonstrated by the implant surface. BIC was positively influenced by the undersized drilling protocol and rough surface, BAFO was negatively influenced by the temperature rise, and BA1.5 was negatively influenced by the undersized drilling protocol. FEM showed that the temperature at the implant interface might exceed the limit for bone necrosis. CONCLUSION: The intraosseous temperature is greatly increased by an undersized drilling protocol but not from the implant surface. The temperature increase negatively affects the bone healing in the proximity of the implant. The undersized drilling protocol for Brånemark implant systems increases the amount of bone at the interface, but it negatively impacts the bone far from the implant.

    DOI: 10.3390/jcm8081198

  • Bone-forming effect of a static magnetic field in rabbit femurs 査読

    Naito, Y., Yamada, S., Jinno, Y., Arai, K., Galli, S., Ichikawa, T., Jimbo, R.

    International Journal of Periodontics and Restorative Dentistry   39 ( 2 )   259 - 264   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    © 2019 by Quintessence Publishing Co Inc. This study investigated the level of magnetic energy around implants possessing a static magnetic field (SMF) and assessed the in vivo influence of SMF on bone regeneration. Implants possessing a sintered neodymium magnet internally were placed in a rabbit femur. An implant without SMF was placed as control. After 12 weeks of healing in vivo, the bone samples were subjected to histologic/histomorphometric evaluation. The bone-toimplant contact for the test group and the control group were 32.4 ± 13.6&#37; and 17.1 ± 4.5&#37;, respectively, and the differences were statistically significant (P < .05). The results suggested that the SMF promoted new bone apposition.

    DOI: 10.11607/prd.3220

  • Effect of misfit at implant-level framework and supporting bone on internal connection implants: Mechanical and finite element analysis 査読

    Toia, M., Stocchero, M., Jinno, Y., Wennerberg, A., Becktor, J.P., Jimbo, R., Halldin, A.

    International Journal of Oral and Maxillofacial Implants   34 ( 2 )   320 - 328   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    © 2019 by Quintessence Publishing Co Inc. Purpose: To evaluate the effect of misfit at implant-level fixed partial dentures (ILFPDs) and marginal bone support on the generation of implant cracks. Materials and Methods: This in vitro study included a mechanical fatigue test and finite element analysis. A mechanical cycling loading test was performed using 16 experimental models, each consisting of two parallel implants subdivided into four groups based on the misfit and the supporting bone condition. The framework, firmly seated at implants, was dynamically loaded vertically with a force of 1,600/160 N and 15 Hz for 1 × 10 6 cycles. Optical microscope, scanning electron microscope (SEM), and computed tomography three-dimensional (CT-3D) analyses were performed to detect impairments. Finite element models, representing the setups in the mechanical fatigue test, were used to represent the fatigue life. Results: None of the mechanical components presented distortion or fracture at the macroscopic level during the test. In a microscopy evaluation, the fatigue test revealed scratches visible in the inner part of the conical portion of the implants regardless of the groups. SEM and CT-3D analysis revealed one implant from the misfit/no bone loss group with a microfracture in the inner part of the conical interface. The simulated effective stress levels in the coronal body were higher in the misfit groups compared with the no misfit groups. The misfit groups presented effective stress levels, above 375 MPa, that penetrated the entire wall thickness. The no bone loss group presented an effective stress level above 375 MPa along its axial direction. In the no misfit group, the area presenting effective stress levels above 375 MPa in the conical connection was larger for the bone loss group compared with the no bone loss group. Conclusion: This study confirmed that implant fracture is an unlikely adverse event. A clear pattern of effective distribution greater than fatigue limit stresses could be noticed when the misfit was present. The dynamic load simulation demonstrated that the crack is more likely to occur when implants are fully supported by marginal bone compared with a bone loss scenario. Within the limitations of this study, it is speculated that marginal bone loss might follow the appearance of an undetected crack. Further research is needed to develop safe clinical protocols with regard to ILFPD.

    DOI: 10.11607/jomi.6965

  • Impact of surface contamination of implants with saliva during placement in augmented bone defects in sheep calvaria 査読 国際誌

    Jinno, Y., Jimbo, R., Hjalmarsson, J., Johansson, K., Stavropoulos, A., Becktor, J.P.

    British Journal of Oral and Maxillofacial Surgery   57 ( 1 )   41 - 46   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Our aim was to try and find out whether contamination with saliva during insertion of dental implants affects osseointegration in bone that has been augmented with different grafts. Six bony defects were created in each of the calvaria of six sheep, and then augmented with three different materials (autogenous bone, bovine bone, and resorbable biphasic ceramic bone substitute) After five weeks of healing, three implants contaminated with saliva (contaminated group) and three not contaminated (uncontaminated group) were placed in the centre of the augmented areas. For histomorphometric analysis, bone implant contact, bone area fraction occupancy, bone and material area, and bony area were measured after a healing period of five weeks. There was a significant difference between the contaminated and uncontaminated groups (p=0.036) for bone implant contact only in the augmented areas, but there were no significant differences in bone area fraction occupancy, bone and material area, and bony area. We conclude that contamination with saliva during placement of dental implants can significantly compromise bone implant contact in augmented areas, but had no significant effect on the formation of bone in areas more distant from the surface of the implant. We suggest that salivary contamination should be avoided during placement of dental implants in augmented areas.

    DOI: 10.1016/j.bjoms.2018.11.014

  • Controlled release of clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects 査読 国際誌

    Alenezi, A., Naito, Y., Terukina, T., Prananingrum, W., Jinno, Y., Tagami, T., Ozeki, T., Galli, S., Jimbo, R.

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   106 ( 1 )   201 - 208   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study evaluated the sustained release effect of clarithromycin-loaded in PLGA microspheres in a rabbit calvaria defect model. Four bone defects (ø5.0) were created in the calvaria of New Zealand White rabbits (n = 21, n = 7/time point). The defects were randomly designated to four groups. Group 1: No augmentation (sham), Group 2: beta-tricalcium phosphate (β-TCP), Group 3: β-TCP with 0.12 µg clarithromycin, and Group 4: β-TCP with 6.12 µg PLGA microspheres loaded with 0.12 µg Clarithromycin. After 2, 4, and 12 weeks of healing, bone regeneration was evaluated using micro-computed tomography (µCT) and histology. Clarithromycin release from PLGA microspheres revealed sustained release for around 4 weeks with ∼50&#37; release during the first week. Histologically, new bone formation was evident at 2 and 4 weeks of healing in all groups and bone formation increased as a function of healing time. At 12 weeks, Group 4 showed significantly higher amount of newly formed bone compared to Group 1. The µCT showed that Group 4 expressed significantly higher bone formation compared to Group 1 at all time points. The in vivo findings showed that β-TCP with clarithromycin-loaded microspheres can enhance bone formation in bone defects. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 201-208, 2018.

    DOI: 10.1002/jbm.b.33844

  • Influence of different drilling preparation on cortical bone: A biomechanical, histological, and micro-CT study on sheep 査読 国際誌

    Stocchero, M., Toia, M., Jinno, Y., Cecchinato, F., Becktor, J.P., Naito, Y., Halldin, A., Jimbo, R.

    Clinical Oral Implants Research   29 ( 7 )   707 - 715   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The aim of this study was to investigate the extent of cortical bone remodeling between two different drilling protocols by means of histomorphometric, µ-CT, and biomechanical analyses. MATERIAL AND METHODS: A total of 48 implants were inserted into the mandible of six sheep following two drilling protocols: Group A (Test, n = 24), undersized preparation; Group B (Control, n = 24), non-undersized preparation. The animals were euthanatized to obtain 5 and 10 weeks of implantation time. Removal torque (RTQ) was measured on 12 implants of each group and the peri-implant bone was µ-CT scanned. Bone volume density (BV/TV) was calculated in pre-determined cylindrical volumes, up to 1.5 mm from implant surface. Non-decalcified histology was prepared on the remaining 12 implants from each group, where total bone-to-implant contact (totBIC) and newly-formed BIC (newBIC) was measured. Bone Area Fraction Occupancy (BAFO) was determined in pre-determined areas up to 1.5 mm from implant surface. Paired sample t test or Wilcoxon signed-rank test was used to investigate differences between the groups. RESULTS: Group A presented significantly increased RTQ value at 5 weeks, while no difference was observed at 10 weeks. Group B presented increased BV/TV value at 5 weeks. Both groups showed comparable values for totBIC at both time-points. However, Group A presented significantly lower newBIC at 5 weeks. Higher BAFO was observed in Group B at 5 weeks. CONCLUSIONS: Implants inserted into undersized sites has an increased biomechanical performance, but provoked major remodeling of the cortical bone during the early healing period compared to non-undersized preparations. After 10 weeks, no difference was observed.

    DOI: 10.1111/clr.13262

  • Vertical bone augmentation using ring technique with three different materials in the sheep mandible bone 査読

    Jinno, Y., Jimbo, R., Lindström, M., Sawase, T., Lilin, T., Becktor, J.P.

    International Journal of Oral and Maxillofacial Implants   33 ( 5 )   1057 - 1063   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    © 2018 by Quintessence Publishing Co Inc. Purpose: The purpose of this study was to examine the volumetric alterations and osseointegration properties in the augmented area of the ring technique using different types of bone graft material in sheep mandible bone. Materials and Methods: Three different materials (columnar forms, 7-mm diameter, 3-mm height) were stabilized using dental implants with a turned surface in the mandible bone of Finnish Dorset cross-bred sheep: group A, autogenous bone; group B, bovine bone; group C, biphasic bone substitute. Animals were euthanized after 5 weeks (N = 6). Three-dimensional image data by digital oral scanner were taken at the surgery and sacrifice, and the volume alteration of the material was calculated. The bone samples were fixed in formalin and dehydrated in ethanol. Resin-embedded samples were subjected to non-decalcified ground sectioning, and histologic and histomorphometric analysis (bone and material area alteration, bone-to-implant contact [BIC]) were done. Results: In three-dimensional (3D) image analysis, group A showed a statistically higher percentage of remaining materials compared with groups B and C. The histologic observation showed no new bone formations around the implants in all groups, especially at the maxillary site of the implant in the augmented area. In histomorphometric analysis, group A showed a statistically higher percentage of bone area (BA) compared with groups B and C; however, in all groups, bone-to-implant contact (BIC) showed low values, and there were no statistical differences between groups. Conclusion: The results of this study suggested that the autogenous bone maintained bone volume around the dental implant using the ring technique, and the impact of surface properties was of some importance; osseointegration with the turned surface in the augmented area showed low BIC values in all groups.

    DOI: 10.11607/jomi.6278

  • Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone. 査読 国際誌

    Galli, S., Andersson, M., Jinno, Y., Karlsson, J., He, W., Xue, Y., Mustafa, K., Wennerberg, A., Jimbo, R.

    Journal of Biomedical Materials Research - Part B Applied Biomaterials   105 ( 7 )   2118 - 2125   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: The release of magnesium ions (Mg2+ ) from titanium surfaces has been shown to boost the initial biological response of peri-implant bone and to increase the biomechanical strength of osseointegration. The objective of the present paper was to investigate if the initial improvement in osseointegration would influence the bone remodeling also during the maturation stage of bone healing. METHODS: Titanium implants were coated with mesoporous titania layers and either loaded with Mg2+ (test group) or left untreated (control group). The implants were inserted in the tibiae of 10 New Zealand White rabbits. Osseointegration was assessed after 6 weeks by means of biomechanical testing (RTQ), non-decalcified histology and histomorphometry (BIC&#37;, BA&#37;, NBA&#37;). The expression of genes involved in the bone formation and remodeling was quantified using qPCR. RESULTS: Mg2+ releasing mesoporous titania coatings showed, on average, higher removal torques and histomorphometrical outcomes (RTQ: 17.2 Ncm vs. 15 Ncm; BIC: 38.8&#37; vs. 32.1&#37;; BA&#37;: 71.6&#37; vs. 64&#37;; NBA&#37; 62.5&#37; vs. 54&#37; for the tests vs the controls); however, the differences were not statistically significant. Three osteogenic markers, osteocalcin (OC), collagen 1 alpha 1 (COL1A1), and alkalin phosphatase (ALPL), were respectively 2-fold, 1.53-fold, and 1.13-fold up-regulated in the control group compared to the test. The expression of COL1A1 was particularly high in both groups, while the biomarkers for remodeling and inflammation showed a low expression in both groups. SIGNIFICANCE: The results suggested that the initial enhancement in osseointegration induced by magnesium release from mesoporous titania coatings has no detrimental effects during bone maturation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2118-2125, 2017.

    DOI: 10.1002/jbm.b.33752

  • Micro-computed tomography analysis of early stage bone healing using micro-porous titanium mesh for guided bone regeneration: preliminary experiment in a canine model 査読

    Rakhmatia, Y.D., Ayukawa, Y., Jinno, Y., Furuhashi, A., Koyano, K.

    Odontology   105 ( 4 )   408 - 417   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to evaluate the amount of bone formation beneath a defect area after treatment with titanium mesh membranes with different thicknesses and pore sizes alone or in combination with bone graft to induce bone formation during the early stage of healing time. The mandibular premolars were extracted bilaterally from three adult beagle dogs, and 8-mm-diameter bone defects were created on the buccal site of the premolar regions. Hydroxyapatite bone graft substitute was applied in the defect site unilaterally, and other site was left empty. Then, a novel micro-porous mesh (50 μm in pore diameter) or commercially available macro-porous titanium mesh (1700 μm in pore diameter) was placed on the defect and secured with screws. After 4 weeks, the mandibles were harvested, imaged using micro-computed tomography, and prepared for histological and morphometric evaluation. Higher new bone volumes (mm3), percentage of new bone volumes in the total defect volumes (bone ratio: &#37;), and new bone area (mm2) through morphometric evaluation were found on the novel membranes with 50-μm-diameter pores compared to the commercial titanium mesh. Moreover, experiment sites without bone graft were observed with higher new bone volume and bone ratio compared with sites with bone graft. However, bone mineral density of novel mesh was observed to be lower compared with other experimental sites. Under the experimental condition, the result of this study suggests that titanium meshes with 50-μm-diameter pores were effective for guided bone regeneration in the early stage of healing.

    DOI: 10.1007/s10266-017-0298-1

  • In vivo evaluation of dual acid-etched and grit-blasted/acid-etched implants with identical macrogeometry in high-density bone 査読 国際誌

    Jinno, Y., Jimbo, R., Tovar, N., Teixeira, H.S., Witek, L., Coelho, P.G.

    Implant Dentistry   26 ( 6 )   815 - 819   2017年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Based on the current evidence, the effect of implant macrogeometry has a significant influence on osseointegration. Thus, this study evaluated histomorphometrically and histologically the bone response to acid-etched in comparison to grit-blasted/acid-etched (GB) and machined control (C) surfaced implants possessing identical macrogeometry placed in high-density bone. MATERIALS AND METHODS: Implant surface topography of the 3 different surfaced implants has previously been characterized. The macrogeometry of the implants were conical, and healing chambers were created in the cortical regions. The 3 groups were placed in the external mandibular body of adult male sheep (n = 5). After 6 weeks in vivo, all samples were retrieved for histologic observation and histomorphometry (eg, bone-to-implant contact [BIC] and bone area fraction occupancy [BAFO]). RESULTS: No statistical difference was observed for BIC and for BAFO, although there was a tendency that the mean values for BAFO was higher for the textured surface groups. CONCLUSIONS: It is suggested that the effect of surface topography is minimal in high-density bone and osseointegration seemed to be macrogeometry dependent.

    DOI: 10.1097/ID.0000000000000672

  • Bone Ingrowth to Ti Fibre Knit Block with High Deformability. 査読

    Henmi Y, Naito Y, Jimbo R, Jinno Y, Sekine K, Hamada K

    Journal of oral & maxillofacial research   7 ( 4 )   2016年10月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5037/jomr.2016.7402

  • Tissue Reaction to a Novel Bone Substitute Material Fabricated with Biodegradable Polymer-Calcium Phosphate Nanoparticle Composite 査読 国際誌

    Shimizu, H., Jinno, Y., Ayukawa, Y., Atsuta, I., Arahira, T., Todo, M., Koyano, K.

    Implant Dentistry   25 ( 5 )   567 - 74   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: The aim of this study was to evaluate the effectiveness of a novel bone substitute material fabricated using a biodegradable polymer-calcium phosphate nanoparticle composite. METHODS: Porous structured poly-L-lactic acid (PLLA) and hydroxyapatite (HA) nanoparticle composite, which was fabricated using solid-liquid phase separation and freeze-drying methods, was grafted into bone defects created in rat calvarium or tibia. Rats were killed 4 weeks after surgery, and histological analyses were performed to evaluate new bone formation. RESULTS: Scanning electron microscopic observation showed the interconnecting pores within the material and the pore diameter was approximately 100 to 300 μm. HA nanoparticles were observed to be embedded into the PLLA beams. In the calvarial implantation model, abundant blood vessels and fibroblastic cells were observed penetrating into pores, and in the tibia model, newly formed bone was present around and within the composite. CONCLUSIONS: The PLLA-HA nanoparticle composite bone substitute developed in this study showed biocompatibility, elasticity, and operability and thus has potential as a novel bone substitute.

    DOI: 10.1097/ID.0000000000000447

  • Implant vertical fractures provoked by laboratory procedures: A finite element analysis inspired from clinical cases 査読 国際誌

    Takeshita, K., Toia, M., Jinno, Y., Sumi, T., Takahashi, T., Halldin, A., Jimbo, R.

    Implant Dentistry   25 ( 3 )   361 - 6   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To investigate the causes for internal implant fractures, which is suggested to be one of the reasons for marginal bone loss. MATERIALS AND METHODS: From a 14-year database of 6051 implants, 10 single implant vertical fractures were identified and the abutments were all castable abutments. The abutments presented contamination and irregularities at the internal connecting areas. The hypothesis was that perfect fit was disturbed by laboratory polishing procedures, and finite element analysis (FEA) using overcorrected and undercorrected castable abutment models were created and tested against a perfect fit model. RESULTS: The results from the FEA presented that both overcorrected and undercorrected models presented nonuniform excessive plastic strain distribution in the neck portion of the implants where clinically an implant fracture was noted. CONCLUSIONS: The results suggested that laboratory procedures could induce plastic strain of the implant-abutment complex, which increases the risk of fracture.

    DOI: 10.1097/ID.0000000000000392

  • Implant stability and bone remodeling up to 84 days of implantation with an initial static strain. An in vivo and theoretical investigation 査読 国際誌

    Halldin, A., Jinno, Y., Galli, S., Ander, M., Jacobsson, M., Jimbo, R.

    Clinical Oral Implants Research   27 ( 10 )   1310 - 1316   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: When implants are inserted, the initial implant stability is dependent on the mechanical stability. To increase the initial stability, it was hypothesized that bone condensation implants will enhance the mechanical stability initially and that the moderately rough surface will further contribute to the secondary stability by enhanced osseointegration. It was further hypothesized that as the healing progresses the difference in removal torque will diminish. In addition, a 3D model was developed to simulate the interfacial shear strength. This was converted to a theoretical removal torque that was compared to the removal torque obtained in vivo. MATERIAL AND METHODS: Condensation implants, inducing bone strains of 0.015, were installed into the left tibia of 24 rabbits. Non-condensation implants were installed into the right tibia. All implants had a moderately rough surface. The implants had an implantation time of 7, 28, or 84 days before the removal torque was measured. The interfacial shear strength at different healing time was estimated by the means of finite element method. RESULTS: At 7 days of healing, the condensation implant had an increased removal torque compared to the non-bone-condensation implant. At 28 and 84 days of healing, there was no difference in removal torque. The simulated interfacial shear strength ratios of bone condensation implants at different implantation time were in line with the in vivo data. CONCLUSIONS: Moderately rough implants that initially induce bone strain during installation have increased stability during the early healing period. In addition, the finite element method may be used to evaluate differences in interlocking capacity.

    DOI: 10.1111/clr.12748

  • Is china’s eight-year stomatology medical doctor program feasible? Comparison of comprehensive quality between doctoral dental students in China and Japan 査読

    Zhang, X., Yan, X., Shen, Y., Jinno, Y., Jiang, X., Koyano, K., Ai, H.

    International Journal of Clinical and Experimental Medicine   9 ( 1 )   448 - 454   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    © 2016, International Journal of Clinical and Experimental Medicine. All rights reserved. Objective: To compare the comprehensive quality between eight-year Stomatology Medical Doctor (S.M.D) Program students of China and doctoral dental students of Japan, hoping to provide some references for improving dental education in China. Methods and materials: Data were collected from self-answered scoring questionnaires, answered by participants from China and Japan. Results: The study showed Chinese student got higher scores in fields of basic knowledge, basic medical knowledge and basic legal knowledge, although their knowledge still needed improving. Chinese students also got higher scores in dental professional quality items, except for teaching capability. They should improve scientific research ability and teaching capability as well. Japanese students got lower scores in items of oral professional diagnosis, treatment level and professional foreign language proficiency. Conclusion: For general quality, Chinese students got higher scores except for social acceptability. Innovation capability and international communication skills were shortcomings for both Chinese and Japanese students. The comparison provides insight of this new dental education program and the program requires further reform in the future.

  • Different study conditions between dental students in China and Japan. 査読 国際誌

    Yan X, Yi Z, Wang X, Jinno Y, Zhang X, Koyano K, Ai H

    International journal of clinical and experimental medicine   8 ( 7 )   11396 - 403   2015年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The purpose of this study was to compare the study conditions of dental students towards dental education in China and Japan. METHODS: 60 students from the Stomatology School of China Medical University and 51 students from the Dental Faculty of Kyushu University, Japan, participated in this study. Information was derived from a self-answered questionnaire consisting of 10 items. RESULTS: More Japanese students (60&#37;) compared to Chinese students (28&#37;) were satisfied with their lives in dental school. For the main reason of discontent, 23.5&#37; of the Japanese students attributed to busy study and lacking of spare time, while 38.3&#37; of the Chinese students indicated small campus lacking of infrastructure. CONCLUSIONS: Both students of two countries think they were in big pressure. The main stressor of Japanese students was the examination, but that of Chinese students was anxiety of their future and obtains employment. The main source of tuition and maintenance was family in the both countries, but more Japanese students (25.5&#37;) were dependent on scholarship compared with Chinese students (3.3&#37;). CLINICAL IMPLICATIONS: The findings from this study enhance our understanding of study conditions among dental students and help to define strategies to improve student management in both Japan and China.

  • Anodized surface and its clinical performance 査読

    Koyano, K., Atsuta, I., Jinno, Y.

    Implant Surfaces and their Biological and Clinical Impact   137 - 145   2015年5月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    © Springer-Verlag Berlin Heidelberg 2015. Many implant surfaces and surface-modification techniques have been examined, and anodized surface on dental implant has been in continued clinical use and has demonstrated good stability during the healing phase. This proof has provided the basis for treatment modality of immediate function. In this chapter, the evidences based on the clinical and basic study reporting the success of osseointegrated implants regarding anodized surface will be reviewed. An understanding of the current evidence may facilitate the most appropriate utilization of this important dental resource.

    DOI: 10.1007/978-3-662-45379-7_10

  • Comparison of attitudes towards dental education among dental students in Japan and China 査読 国際誌

    Yan, X., Zhang, X., Jinno, Y., Tachibana, K., Gao, J., Koyano, K., Shen, Y., Ai, H.

    International Dental Journal   64 ( 2 )   76 - 82   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to identify and compare the attitudes of dental students towards dental education in Japan and China. Fifty-four dental students from the Stomatology School of China Medical University and 51 dental students from the Dental Faculty of Kyushu University, Japan, participated in this study. Information was derived from a self-answered questionnaire consisting of 11 items. Significant differences in the responses of the participants from the two countries were detected for 10 of the questionnaire items (P < 0.05). Nearly three-quarters of the Japanese students were satisfied with the teaching faculties of their schools, while only a quarter of the Chinese students indicated satisfaction. A total of 69&#37; of Chinese students thought that learning a foreign language wasted too much time compared with none of the Japanese students. A student-oriented teaching mode was not well accepted by either of the groups, and 62&#37; of Chinese students and 53&#37; of Japanese students wanted to increase the duration of the clinical practice stage of education. The findings from this study enhance our understanding of differences and/or similarities among dental students in the two nations. This information may help to define strategies to improve the quality of dental education, and especially exchange programmes of international students.

    DOI: 10.1111/idj.12065

  • Career choice and future design of dental students in China and Japan 査読 国際誌

    Yan, X., Zhang, X., Jinno, Y., Tachibana, K., Gao, J., Koyano, K., Ai, H., Shen, Y.

    International Dental Journal   64 ( 2 )   68 - 75   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The purpose of this study was to compare career choice and future plans of dental students in China and Japan. Information was derived from a self-answered questionnaire. Significant differences were detected for eight items between the two countries. Regarding motivation towards career choice, 41&#37; of Japanese students indicated positive motives related to helping others, achieving self-worth and health-care related interests, whereas Chinese students indicated that their choice was mainly for financial and prestige reasons, and for 32&#37; of them, dentistry was a passive choice. More Chinese dental students (74&#37;) wanted further education compared with Japanese students (22&#37;). The majority of Japanese students (56.9&#37;) planned to work as general dentists. Conversely, Chinese students were more likely to specialise (50&#37;). More than 50&#37; of Japanese students wanted to work in dental offices, but the majority of Chinese students (65&#37;) preferred university hospital. We found it is strange that nearly one-fourth of the Chinese students did not want to be a clinical dentist mainly because of the poor health-care environment. This study provides a description of the perspectives of Japanese and Chinese dental students and enables a better understanding of career choices and future course design issues.

    DOI: 10.1111/idj.12064

  • Evaluations of epithelial sealing and peri-implant epithelial down-growth around "step-type" implants 査読 国際誌

    Atsuta, I., Ayukawa, Y., Ogino, Y., Moriyama, Y., Jinno, Y., Koyano, K.

    Clinical Oral Implants Research   23 ( 4 )   459 - 66   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Implant designs that can stimulate and integrate with an epithelial wound-healing process may significantly enhance the efficacy of dental implants. Here, we evaluated the potential of "step-type" implant systems to improve the sealing between the peri-implant epithelium (PIE) and the implant surface, and investigated the effect of implant structure on PIE down-growth. MATERIALS AND METHODS: Right maxillary first molars were extirpated from rats and implanted with either a straight-type or a step-type implant varying in step height and/or width (N(s): 0.8 mm height, 0.1 mm width; W(s): 0.8 mm height, 0.2 mm width; H(s): 0.4 mm height, 0.1 mm width). Maxillae were harvested at various time points over 16 weeks to evaluate laminin-5 distribution as an indicator of wound healing and PIE formation, horse-radish peroxidase (HRP) penetration as a measurement of epithelial sealing, and PIE down-growth formation. RESULTS: In all implant models, the PIE formed from the oral sulcular epithelium and spread apically along the implant surface. In the W(s) group, HRP penetration was detected only in the coronal region of the PIE at 4 weeks, whereas in the straight-type, it was observed in the apical region and the connective tissue. At 16 weeks, the W(s) implants exhibited markedly less PIE down-growth than the Con, N(s) or H(s) implants, and were equivalent to that observed in natural teeth. CONCLUSION: The step-type implant system may have the potential for improving epithelial sealing at the tissue-implant interface, as well as reducing apical PIE down-growth, thus enhancing dental implant efficacy.

    DOI: 10.1111/j.1600-0501.2011.02163.x

  • Simvastatin enhances bone formation around titanium implants in rat tibiae 査読 国際誌

    Ayukawa, Y., Ogino, Y., Moriyama, Y., Atsuta, I., Jinno, Y., Kihara, M., Tsukiyama, Y., Koyano, K.

    Journal of Oral Rehabilitation   37 ( 2 )   123 - 30   2010年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Statins are cholesterol-lowering drugs that have been reported to promote bone formation. The purpose of this study was to investigate the effect of simvastatin on the enhancement of bone formation around titanium implants. Thirty-week-old female rats received pure titanium implants in both tibiae. The animals were intra-peritoneally administered 0, 0.125, 1, 5 or 10 mg kg(-1) of simvastatin daily. After 30 days, the animals were sacrificed, and specimens were prepared. The bone contact ratio of the implant, bone density in the medullary canal and percentage of cortical bone were obtained. Markers for bone turnover were also measured using sera collected at the time of euthanasia. In the medullary canal, a scanty amount of bone was observed in the 0, 0.125 and 1 mg kg(-1) groups. In contrast, in both the 5 and 10 mg kg(-1) groups, thicker bone trabeculae were abundant. Histometric observations showed that the bone contact ratio and the bone density of both groups were significantly greater than those of the other groups (anova, P < 0.01). However, no significant difference in the percentage of cortical bone was found between groups. Serum chemistry showed that statin increased bone formation markers and decreased bone resorption markers. In conclusion, although the dose equivalent to that used in human patients with hypercholesterolemia was not effective, a simvastatin dose of 5 mg kg(-1) or higher increased medullary bone formation around the titanium. In contrast, no effect of simvastatin on pre-existing cortical bone was indicated.

    DOI: 10.1111/j.1365-2842.2009.02011.x

  • The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia. 査読 国際誌

    Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino Y, Koyano K.

    Biomaterials,31,12,3327-3334,2010.04.   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia 査読 国際誌

    Masuzaki, T., Ayukawa, Y., Moriyama, Y., Jinno, Y., Atsuta, I., Ogino, Y., Koyano, K.

    Biomaterials   31 ( 12 )   3327 - 34   2010年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone.

    DOI: 10.1016/j.biomaterials.2010.01.016

  • Simvastatin enhances bone formation around titanium implants in rat tibiae. 査読 国際誌

    Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K.

    Journal of Oral Rehabilitation,37,2,123-130,2009.11.   2009年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Vertical bone augmentation with fluvastatin in an injectable delivery system: A rat study 査読 国際誌

    Jinno, Y., Ayukawa, Y., Ogino, Y., Atsuta, I., Tsukiyama, Y., Koyano, K.

    Clinical Oral Implants Research   20 ( 8 )   756 - 60   2009年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: HMG-CoA reductase inhibitors (statins) are widely used for hyperlipidemia. Previous studies demonstrate that statins stimulate bone morphogenetic protein-2 (BMP-2) expression and lead to bone formation. The aim of this study was to evaluate whether percutaneously injected statin with a novel statin delivery system achieved vertical bone augmentation. MATERIAL AND METHODS: As experimental groups, atelocollagen-alpha-tricalcium phosphate (alphaTCP) composites containing 3.3 mg (low dose) or 6.7 mg (high dose) of fluvastatin were injected (one shot) subcutaneously over the calvarial periosteum of rats. The animals were then sacrificed 1, 2, and 4 weeks after injection. Vertically augmented bone was assessed by histomorphometric procedures, i.e., by measuring new bone thickness (NBT) and bone density (BD). RESULTS: In control groups, no newly formed bone could be seen over the calvarial bone. In the experimental groups, in contrast, a large amount of newly formed bone could be seen over the preexisting calvarial bone. The newly formed bone was seen to be in direct contact with the preexisting bone. During the entire observation, significant NBT was observed in the experimental groups (P<0.05). At the final stage of observation (4 weeks), NBT was 66.7&#37; (low-dose group) and 59.7&#37; (high-dose group), while they were from 1&#37; to 16.3&#37; in the control groups. In the experimental groups, BD significantly increased in a time-dependent manner. CONCLUSION: Percutaneously applied fluvastatin (one shot) with a composite of alphaTCP and collagen has great potential to augment the height of the bone.

    DOI: 10.1111/j.1600-0501.2008.01665.x

  • Vertical bone augmentation with fluvastatin in an injectable delivery system: a rat study. 査読 国際誌

    Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyama Y, Koyano K.

    Clinical Oral Implants Research,20,8,756-760,2009.05   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 北欧モデル スウェーデン歯科医療のホントのところ インプラント周囲炎の捉え方

    内藤 禎人, 神野 洋平, 西 真紀子, Klinge Bjoern, Birkhed Dowen

    歯界展望   144 ( 3 )   569 - 574   2024年9月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • 北欧モデル スウェーデン歯科医療のホントのところ 補綴学的観点からインプラント治療の発展と現状

    神野 洋平, 西 真紀子, 内藤 禎人, Birkhed Dowen, Klinge Bjoern

    歯界展望   144 ( 2 )   403 - 407   2024年8月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • 北欧モデル スウェーデン歯科医療のホントのところ 歯周炎治療 スウェーデンの視点

    Klinge Bjoern, 西 真紀子, 内藤 禎人, 神野 洋平, Birkhed Dowen

    歯界展望   144 ( 1 )   156 - 161   2024年7月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • スウェーデンの小児歯科学と矯正歯科学

    Birkhed Dowen, 西 真紀子, 内藤 禎人, 神野 洋平, Klinge Bjoern

    歯界展望   143 ( 6 )   1186 - 1191   2024年6月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • 北欧モデル スウェーデン歯科医療のホントのところ カリオロジー 食物と微生物

    Birkhed Dowen, 西 真紀子, 内藤 禎人, 神野 洋平, Klinge Bjoern

    歯界展望   143 ( 5 )   986 - 989   2024年5月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • 北欧モデル スウェーデン歯科医療のホントのところ カリオロジー 背景とフッ化物

    Birkhed Dowen, 西 真紀子, 内藤 禎人, 神野 洋平, Klinge Bjoern

    歯界展望   143 ( 4 )   775 - 780   2024年4月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • 北欧モデル スウェーデン歯科医療のホントのところ 歯科医療費と報酬のしくみ

    西 真紀子, 内藤 禎人, 神野 洋平, Klinge Bjoern, Birkhed Dowen

    歯界展望   143 ( 3 )   569 - 574   2024年3月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • 北欧モデル スウェーデン歯科医療のホントのところ 歯科医療サービスの実際

    西 真紀子, 内藤 禎人, 神野 洋平, Klinge Bjoern, Birkhed Dowen

    歯界展望   143 ( 2 )   372 - 376   2024年2月   ISSN:0011-8702

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    記述言語:日本語   出版者・発行元:医歯薬出版(株)  

  • IOS最前線 臨床アプローチの実際 概論

    鮎川 保則, 神野 洋平, 安波 礼之

    日本歯科評論   84 ( 1 )   9 - 13   2024年1月   ISSN:0289-0909

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    記述言語:日本語   出版者・発行元:(株)ヒョーロン・パブリッシャーズ  

  • 【長期予後を見据えたインプラント周囲の硬・軟組織の評価法を考える】インプラント体周囲硬組織を理解し評価するために 臨床論文からみえてくるもの,基礎研究からわかること

    神野 洋平

    日本口腔インプラント学会誌   36 ( 4 )   218 - 223   2023年12月   ISSN:0914-6695

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    記述言語:日本語   出版者・発行元:(公社)日本口腔インプラント学会  

    インプラント体周囲硬組織の評価は,治療計画の立案から経過観察に至るまでのすべてのタイミングにおいて治療の成功・失敗に直結する重要事項である.臨床現場における主な硬組織評価法はエックス線診断・埋入トルク値の計測・共振周波数解析であり,非常に有効な評価方法であることがすでに多くの基礎研究・臨床研究で示されている.さらなるインプラント治療の高い成功率の達成のためには,これらの硬組織評価方法では評価できない骨内変化を理解することが必要であると考えている.本論文では主に埋入術式の違い,荷重負荷の有無による骨内変化に焦点を当てて解説する.研究データの積み重ねにより,解剖学的なリスクの回避,適切な部位への埋入といった従来の評価基準に加え,適切な埋入術式,適切な荷重負荷開始時期,さらには周囲骨吸収の予測などが術前に評価可能となるオーダーメイド型の硬組織評価法が構築されていくことを期待している.(著者抄録)

  • 新たに登場した生体材料のポリエーテルエーテルケトン(PEEK)による骨・軟組織との結着効率改善を目的とした現行の表面改質戦略 文献レビュー(Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone(PEEK) with bone and soft tissue: A literature review)

    Chen Tianjie, Jinno Yohei, Atsuta Ikiru, Tsuchiya Akira, Stocchero Michele, Bressan Eriberto, Ayukawa Yasunori

    Journal of Prosthodontic Research   67 ( 3 )   337 - 347   2023年7月   ISSN:1883-1958

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    記述言語:英語   出版者・発行元:(公社)日本補綴歯科学会  

  • Current surface modification strategies to improve the binding efficiency of emerging biomaterial polyetheretherketone (PEEK) with bone and soft tissue: A literature review

    Tianjie Chen, Yohei Jinno, Ikiru Atsuta, Akira Tsuchiya, Michele Stocchero, Eriberto Bressan, Yasunori Ayukawa

    Journal of Prosthodontic Research   67 ( 3 )   337 - 347   2023年   ISSN:1883-1958

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    掲載種別:書評論文,書評,文献紹介等  

    Purpose: The aim of this study was to review the literature on current surface modification strategies used to improve the binding efficiency of an emerging biological material, polyetheretherketone (PEEK), with bone and soft tissues. Study selection: This review was based on articles retrieved from PubMed, Google Scholar, Web of Science, and Scien-ceDirect databases. The main keywords used during the search were “polyetheretherketone (PEEK),” “implant,” “surface modification,” “biomaterials,” “bone,” “osseointegration,” and “soft tissue.” Results: The suitability of PEEK surface modification strategies has been critically analyzed and summarized here. Many cell and in vivo experiments in small animals have shown that the use of advanced modification technologies with appropriate surface modification strategies can effectively improve the surface inertness of PEEK, thereby improving its binding efficiency with bone and soft tissues. Conclusions: Surface modifications of PEEK have revealed new possibilities for implant treatment; however, most results are based on in vitro or short-term in vivo evaluations in small animals. To achieve a broad application of PEEK in the field of oral implantology, more in vivo experiments and long-term clinical evaluations are needed to investigate the effects of various surface modifications on the tissue integration ability of PEEK to develop an ideal implant material.

    DOI: 10.2186/jpr.JPR_D_22_00138

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  • 各種骨補填材料を用いたリングテクニックによるインプラント体周囲における垂直的骨増生

    神野 洋平

    日本口腔インプラント学会誌   2019年6月

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    記述言語:日本語  

  • 【海外の基礎研究はインプラント治療をどう変えたか?:From Bench to Clinic】アンダーサイズドリリングテクニックがインプラント体周囲骨組織に与える影響

    神野 洋平, Stocchero Michele, Toia Marco, Becktor Jonas P.

    日本口腔インプラント学会誌   2019年6月

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    記述言語:日本語  

    インプラント治療は,口腔内欠損補綴治療になくてはならない治療オプションの一つである.初期固定はオッセオインテグレーション獲得の必要条件であり,即時負荷・早期負荷が一般的な術式になるに従い,より安定した初期固定が要求されるようになってきた.高い初期固定値獲得のため,インプラント体のマクロ・マイクロレベルのデザインの変更,新しい術式など多くの工夫が紹介されてきた.アンダーサイズドリリングテクニックは最も一般的に臨床採用されているインプラント外科手技である.埋入するインプラント体の直径より小さな径の埋入窩を形成することにより,インプラント体と骨の界面で生じる圧縮応力に期待し初期固定を得る術式である.外科医は,埋入トルク値としてその効果を感じることができる.アンダーサイズドリリングは広く普及した術式であるが,まだまだ解明されていない側面も多い.インプラント体埋入時の大きな圧縮力が周囲骨組織の微小損傷を惹起し,治癒期間中にネガティブな影響を与える.すなわち骨の材料特性の低下・インプラント体の安定の低下・周囲骨の吸収・そして最悪の場合インプラント体の喪失につながる可能性があるという仮説のもと,アンダーサイズドリリングテクニックについてさらなる理解を深めることが本論文の目的である.われわれの研究の着想に至った背景および,第48回日本口腔インプラント学会学術大会・シンポジウム10で発表した研究結果を紹介する.(著者抄録)

  • 海外の基礎研究はインプラント治療をどう変えたか? From Bench to Clinic インプラント体周囲組織の反応 種々の検討から見えてくるもの

    神野 洋平

    日本口腔インプラント学会学術大会抄録集   2018年9月

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    記述言語:日本語  

  • 3次元多孔性チタン織物の変形能とin vivoにおける骨伝導能

    邉見 蓉子, 内藤 禎人, 神保 良, 神野 洋平, 関根 一光, 浜田 賢一

    日本バイオマテリアル学会大会予稿集   2016年11月

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    記述言語:日本語  

  • インプラント体周囲骨を考える インテグレーションとその安定に及ぼす因子

    神野 洋平

    日本口腔インプラント学会誌   2016年8月

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    記述言語:日本語  

  • インプラント最先端表面改質の可能性と臨床応用への課題

    神保 良, 神野 洋平, 柴原 清隆, 内藤 禎人

    Japanese Journal of Maxillo Facial Implants   2015年4月

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    記述言語:日本語  

    インプラントの表面性状に関する研究は過去20年間活発に行われている。開発当初のインプラント体表面は滑面であったが、治療期間の短縮と、より強固なオッセオインテグレーション獲得を目指して、様々な粗面性状の研究がなされてきた。これまでのインプラント表面改質に関する研究の変遷と現状、さらに今後の展望について解説した。

  • 【補綴臨床イノベーションのための若手研究者の挑戦1】バイオマテリアルエンジニアリングの新たな展開 スタチンの局所投与による新しい骨増生術式および骨補填材料の開発

    神野 洋平, 古谷野 潔

    歯界展望   2014年4月

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    記述言語:日本語  

  • インプラント支持可撤性ブリッジの適用による下顎部分欠損症例の補綴治療

    神野 洋平

    日本補綴歯科学会誌   2014年1月

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    記述言語:日本語  

    症例の概要:患者は初診時61歳の男性。悪性リンパ腫に対する放射線治療後の部分無歯顎に対する補綴治療の症例である。右下顎歯7、6、5部にインプラントを埋入し、コーヌス型オーバーデンチャーで補綴を行った。考察:インプラント体埋入位置が限定され、最終補綴装置の設計も力学的に問題のある設計となった。しかし、最終補綴装置装着後の定期的なメインテナンスによりインプラント体自体に大きな問題は生じていない。今後さらに経過を観察していく必要がある。結論:放射線治療後の下顎部分無歯顎症例に対し、インプラントを用いたコーヌス型オーバーデンチャーで咬合支持を再建することができた。(著者抄録)

  • 【臨床イノベーションのための若手研究者の挑戦 バイオマテリアル・エンジニアリングの新たな展開】新しい骨増生術式および骨補填材料の開発 スタチンの局所投与

    神野 洋平

    日本補綴歯科学会誌   2013年10月

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    記述言語:日本語  

    インプラント治療において、骨量不足症例への挑戦が増加し、骨増生の重要性が高まっている。骨増生に関する我々の研究を紹介する。(1)骨増生の簡便化を目指し新術式の開発を行っている。単回のスタチン注射投与による無切開・非侵襲的骨増生を提案する。スタチンの骨形成作用に関する研究から、今回の開発に至った経緯について解説する。(2)"骨を模倣する"というコンセプトで骨補填材料の開発を行っている。組織再生に必要な要素として、細胞、成長因子、足場、血流が知られており、骨とりわけ海綿骨はすべての要素を含んでいる。合成高分子化合物をスタート材料とした、海綿骨を模倣した自己細胞侵入型骨補填材を紹介する。(著者抄録)

  • 生体内分解性高分子化合物を用いた骨組織再生用新規マテリアルの開発

    清水 秀夫, 神野 洋平, 鮎川 保則, 熱田 生, 古谷野 潔

    日本口腔インプラント学会誌   2013年9月

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    記述言語:日本語  

  • 臨床イノベーションのための若手研究者の挑戦 バイオマテリアル・エンジニアリングの新たな展開 新しい骨増生術式および骨補填材料の開発 スタチンの局所投与

    神野 洋平

    日本補綴歯科学会誌   2013年5月

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    記述言語:日本語  

  • インプラントの撤去を訴えた患者に補綴と心理面の両面から対処した1症例

    松下 恭之, 木原 優文, 神野 洋平, 江崎 大輔, 古谷野 潔

    日本口腔インプラント学会誌   2012年9月

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    記述言語:日本語  

  • 検査用グミゼリーを用いた咀嚼能率評価法と粒度解析法の関係

    橋本 恵, 杉本 恭子, 稲田 絵美, 覺道 昌樹, 神野 洋平, 田中 恭恵, 田中 睦都, 中村 真弓, 林 亜紀子, 星野 正憲, 美甘 真, 宮嶋 隆一郎, 李 強, 佐々木 啓一, 沖 和広, 山本 雅章, 近藤 重悟, 小野 高裕, 野首 孝祠, 皆木 省吾

    日本顎口腔機能学会雑誌   2012年2月

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    記述言語:日本語  

  • グミゼリーを用いた咀嚼能率評価法における視覚判定、成分溶出および粒度解析の関係

    杉本 恭子, 橋本 恵, 稲田 絵美, 覺道 昌樹, 神野 洋平, 田中 恭恵, 田中 睦都, 中村 真弓, 林 亜紀子, 星野 正憲, 美甘 真, 宮嶋 隆一郎, 李 強, 佐々木 啓一, 沖 和広, 山本 雅章, 近藤 重悟, 小野 高裕, 野首 孝祠, 皆木 省吾

    日本顎口腔機能学会雑誌   2012年2月

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    記述言語:日本語  

    咀嚼能力はその評価すべき特性の多面性からこれまでに直接的及び間接的な評価法が多数検討されており、グミゼリーを被験食品とした研究では、成分の溶出計測や粉砕状況に応じたスコア化など種々の評価法を用いた報告がなされている。しかし、グミゼリー食塊粒子の詳細な粒度解析と成分溶出との関係についてはいまだ明らかになっていない。そこで本研究は、検査用グミゼリーを被験食品として含有β-カロチンの溶出量と、視覚判定による咀嚼能率スコアならびに画像解析による粒度解析との比較を行うことを目的とした。被験者は、成人健常有歯顎者17名(男性9名、女性8名、25~53歳、平均30.8±6.9歳)とした。粒度計測はデジタル画像解析にて行い、β-カロチンは35℃の水に対する規定条件下での溶出量を評価した。咀嚼能率スコアは標準画像との比較により視覚的に決定した。咀嚼能率スコアと被験食塊中の最大粒子面積との間には有意の負の相関関係(p<0.001)が認められた。また1mm2~50mm2の面積をもつ粒子の合計面積が咀嚼塊総面積に占める比率と溶出評価用センサ出力電圧との間に有意の負の相関関係(p<0.001)が認められた。以上の結果より、検査用グミゼリーからのβ-カロチン溶出量、目視による咀嚼能率スコアならびに粒度解析の結果は互いに相関関係が認められることが示された。(著者抄録)

  • エレクトロフォーミングシステムを用いたインプラント支持可撤性ブリッジ(コーヌス型オーバーデンチャー)の適用による下顎部分欠損症例の補綴治療

    神野 洋平

    日本補綴歯科学会誌   2012年1月

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    記述言語:日本語  

  • アテロコラーゲンをキャリアとして用いたスタチン局所投与によるインプラント周囲骨形成促進作用の検討

    益崎 与泰, 鮎川 保則, 森山 泰子, 神野 洋平, 古谷野 潔

    日本口腔インプラント学会誌   2011年8月

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    記述言語:日本語  

  • 下顎片側臼歯部欠損に対してインプラント補綴治療を行った1症例

    神野 洋平

    日本口腔インプラント学会誌   2011年3月

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    記述言語:日本語  

  • チタンインプラントに対する口腔粘膜上皮細胞接着 : PI3-kinase の役割について

    熱田 生, 鮎川 保則, 荻野 洋一郎, 森山 泰子, 神野 洋平, 古谷野 潔

    日本補綴歯科学会誌. 特別号, 社団法人日本補綴歯科学会学術大会プログラム・抄録集 = Program and abstracts, the ... scientific meeting of Japan Prosthodontic Society   2010年8月

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    記述言語:日本語  

    The Adhesion of Oral Epithelial Cells to the Titanium Implant : The Role of Phosphatidylinositol 3-Kinase

  • インプラント周囲骨形成に対するスタチン遠隔単回投与の効果 骨粗鬆症モデルラットを用いた組織学的研究

    益崎 与泰, 鮎川 保則, 森山 泰子, 熱田 生, 神野 洋平, 古谷野 潔

    日本再生歯科医学会誌   2009年12月

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    記述言語:日本語  

  • 長期徐放性キャリアを用いたフルバスタチン遠隔単回投与がインプラント周囲骨に与える影響

    益崎 与泰, 鮎川 保則, 森山 泰子, 神野 洋平, 熱田 生, 築山 能大, 古谷野 潔

    日本口腔インプラント学会誌   2009年8月

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    記述言語:日本語  

  • 高脂血症治療薬statinの局所投与による骨増生

    神野 洋平, 鮎川 保則, 荻野 洋一郎, 熱田 生, 古谷野 潔

    日本再生歯科医学会誌   2008年12月

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    記述言語:日本語  

  • プラットホームスイッチングシステムは上皮封鎖性の向上に有効か?

    熱田 生, 鮎川 保則, 荻野 洋一郎, 森山 泰子, 神野 洋平, 古橋 明大, 古谷野 潔

    日本口腔インプラント学会誌   2008年8月

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    記述言語:日本語  

  • Comparative Studies of the Peri-implant Epithelium of Rat Gingivae between "Step-type" and "Straight-type" Implant System

    ATSUTA I, AYUKAWA Y, OGINO Y, MORIYAMA Y, JINNO Y, KOYANO K

    日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society   2008年6月

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    記述言語:英語  

    Comparative Studies of the Peri-implant Epithelium of Rat Gingivae between "Step-type" and "Straight-type" Implant System

  • 新規ドラッグデリバリーシステムを用いたスタチンによる骨増生

    神野 洋平, 鮎川 保則, 荻野 洋一郎, 熱田 生, 古谷野 潔

    日本口腔インプラント学会誌   2008年3月

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    記述言語:日本語  

  • スタチン含β-TCPの骨補填材としての応用 ラットを用いた組織学的研究

    安川 英輔, 鮎川 保則, 荻野 洋一郎, 熱田 生, 神野 洋平, 森山 泰子, 古谷野 潔

    日本口腔インプラント学会誌   2007年3月

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    記述言語:日本語  

▼全件表示

所属学協会

  • 日本顎顔面補綴学会

  • 日本補綴歯科学会

  • 日本口腔インプラント学会

  • International College of Prosthodontists

  • Europian Association for Osseointeration

  • 一般社団法人日本顎顔面補綴学会

  • 公益社団法人日本口腔インプラント学会

  • 公益社団法人日本補綴歯科学会

  • 公益社団法人日本補綴歯科学会

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  • 公益社団法人日本口腔インプラント学会

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  • 一般社団法人日本顎顔面補綴学会

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委員歴

  • 公益社団法人日本補綴歯科学会   運営委員   国内

    2021年7月 - 2023年6月   

  • 公益社団法人日本補綴歯科学会   国際委員会   国内

    2021年7月 - 2023年6月   

  • 公益社団法人日本補綴歯科学会   渉外委員会委員  

    2021年7月 - 2023年6月   

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    団体区分:学協会

    researchmap

  • 公益社団法人日本口腔インプラント学会   運営委員   国内

    2020年8月 - 2022年7月   

  • 公益社団法人日本口腔インプラント学会   国際渉外委員会   国内

    2020年8月 - 2022年7月   

  • 公益社団法人日本口腔インプラント学会   国際委員会委員  

    2020年6月 - 2024年7月   

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学術貢献活動

  • 座長 国際学術貢献

    日中韓補綴歯科学会  ( 広州 ) 2024年3月

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    種別:大会・シンポジウム等 

  • 学術論文等の審査

    役割:査読

    2022年

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    種別:査読等 

    外国語雑誌 査読論文数:23

    日本語雑誌 査読論文数:0

    国際会議録 査読論文数:0

    国内会議録 査読論文数:15

共同研究・競争的資金等の研究課題

  • 薬剤関連顎骨壊死の粘膜閉鎖不全に対する幹細胞由来ミトコンドリアを用いた新規治療法

    研究課題/領域番号:24K02634  2024年4月 - 2028年3月

    科学研究費助成事業  基盤研究(B)

    熱田 生, 神野 洋平, 上田 将之, 鮎川 保則, 古橋 明大

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    資金種別:科研費

    本研究では3つの「問い」を解明する。すなわち、1)MRONJの病態の一つである口腔粘膜の閉鎖不全は上皮細胞のミトコンドリアの異常によるものか?2)MSCによる不良ミトコンドリアの交換がOECの局所的な異常性も改善し、MRONJの治療に寄与できるか? 3)細胞投与ではなく、ミトコンドリアを直接治療に生かすことができるか?である。

    CiNii Research

  • AIを用いた即時負荷・早期負荷のための歯科インプラント術前診断支援システムの構築

    研究課題/領域番号:22K10103  2022年 - 2024年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    神野 洋平, 山口 哲, 鮎川 保則

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    資金種別:科研費

    歯科インプラント治療の現状の手術支援システムは、CT画像から再構築された3次元モデルで、インプラント体のサイズを決定することを主目的としており、即時・早期負荷の可否の判断に用いることはできない。
    本研究の目的は即時・早期負荷の判断を支援を行うための術前診断システムを構築することである。インプラント体埋入後の周囲骨のマイクロレベルの形態変化、埋入時の周囲骨内温度変化に注目し、動物実験および有限要素解析によりデータ収集を行い、失敗リスクを予測可能なAIアルゴリズムを実装したシステムの開発を目指す。

    CiNii Research

  • 間葉系幹細胞の不良ミトコンドリアを標的とした薬剤関連顎骨壊死の新規治療法の構築

    研究課題/領域番号:23K21491  2021年4月 - 2025年3月

    科学研究費助成事業  基盤研究(B)

    熱田 生, 神野 洋平, 鮎川 保則, 上田 将之, 鬼村 由梨

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    資金種別:科研費

    本研究ではMSCのミトコンドリアに注目し、細胞自体ではなく細胞小器官であるミトコンドリアを対象とした治療の可能性を示すことが目的である。ミトコンドリアに注目してMSCによる疾患の制御を解明すること自体が、学術的独自性や創造性が高いと思われる。また本件研究によって得られた結果は、MRONJに留まらず種々の疾患の新たな治療法として提案できる可能性がある。

    CiNii Research

  • 間葉系幹細胞の不良ミトコンドリアを標的とした薬剤関連顎骨壊死の新規治療法の構築

    研究課題/領域番号:21H03133  2021年 - 2024年

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    資金種別:科研費

  • 埋入時注水冷却で歯科インプラント体の早期脱落を予防する

    研究課題/領域番号:20K23031  2020年 - 2021年

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

    神野 洋平

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    資金種別:科研費

    インプラント補綴治療において即時・早期負荷を選択することが増えており、埋入時の初期固定獲得が治療成功のための必須条件とされている。アンダーサイズドリリングは初期固定獲得のための一般的な術式である。しかし過度のアンダーサイズドリリングによる高トルク埋入は早期失敗の一因とされておりその術式は諸刃の剣である。埋入窩形成時には骨の火傷防止のために注水冷却を行うが、埋入時には一般的ではない。
    高トルク埋入時の周囲骨内の形態変化は、埋入時の周囲骨内温度上昇により惹起されており注水により軽減する事が出来るという仮説の元、埋入時の注水冷却が骨内の形態変化を軽減し骨治癒に影響を及ぼすかどうかを明らかにする。

    CiNii Research

  • 歯科インプラント治療術前リスク診断システム構築のための萌芽的研究

    2020年 - 2021年

    公益財団法人臨床研究奨励基金 臨床研究助成

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    担当区分:研究代表者  資金種別:受託研究

  • 過硝酸溶液を用いた新規殺菌方法のインプラント周囲炎治療法への応用

    研究課題/領域番号:18K09685  2018年 - 2021年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    江崎 大輔, 都留 朋子, 松下 恭之, 鮎川 保則, 古谷野 潔, 神野 洋平

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    資金種別:科研費

    本研究は、titanium 表面に形成されたバイオフィルムに対する過硝酸(HOONO2;PNA(Peroxynitric acid))の殺菌効果について検討した。CFU assayの結果、2.3 mmol/L以上の濃度のPNAでは、菌数が10秒で検出限界以下となった。他の消毒薬と比較し、PNAが、細菌汚染したtitanium表面のバイオフィルムの殺菌に有用であることが示唆された。
    さらにPNAによる歯科用印象材の殺菌効果についても検討した。菌数は10分で検出限界以下となった。

    CiNii Research

  • 自己細胞侵入型新規骨補填材の開発-海綿骨を模倣する-

    研究課題/領域番号:25463005  2013年 - 2016年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    担当区分:研究代表者  資金種別:科研費

  • 自己細胞侵入型新規骨補填材の開発―海綿骨を模倣する―

    研究課題/領域番号:25463005  2013年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      詳細を見る

    資金種別:科研費

  • 骨増生の予知性を高める新規手法の開発とその効果の検討

    研究課題/領域番号:23390445  2011年 - 2013年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      詳細を見る

    資金種別:科研費

  • 補綴前骨増生治療用新規スポンジ状骨補填材の開発—新術式に向けた研究—

    研究課題/領域番号:23792233  2011年 - 2012年

    科学研究費助成事業  若手研究(B)

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    担当区分:研究代表者  資金種別:科研費

  • 補綴前骨増生治療用新規スポンジ状骨補填材の開発-新術式に向けた研究-

    研究課題/領域番号:23792233  2011年 - 2012年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      詳細を見る

    資金種別:科研費

  • 非侵襲的インプラント術前骨増生法の開発-臨床応用に向けた研究-

    研究課題/領域番号:21791907  2009年 - 2010年

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    資金種別:科研費

▼全件表示

教育活動概要

  • 学部学生の基礎実習(4年生)臨床実習(5年生、6年生)に携わっている。
    その他関連コメディカルへの教育も行っている。

    大学院生の、臨床・研究の指導にも携わっており、特に歯科インプラント治療に関連する研究を共に遂行している。

    その他、歯科医師への講演、教育活動も積極的に行なっている。

担当授業科目

  • 部分床義歯補綴学

    2024年10月 - 2025年3月   後期

  • 全部床義歯補綴学

    2024年4月 - 2024年9月   前期

  • 口腔インプラント学

    2023年4月 - 2023年9月   前期

  • 歯科臨床実習

    2011年4月 - 2012年3月   通年

  • 歯科臨床実習

    2010年4月 - 2011年3月   通年

国際教育イベント等への参加状況等

  • 2021年6月

    11 universities from Sweden and 8 universities from JAPAN

    MIRAI 2.0 R&I Week 2021

      詳細を見る

    開催国・都市名:WEB

    参加者数:500

その他教育活動及び特記事項

  • 2020年  その他特記事項  4年次 全部床義歯補綴学基礎実習担当 5年次 補綴学臨床予備実習担当 5年次 6年次 臨床実習担当

     詳細を見る

    4年次 全部床義歯補綴学基礎実習担当
    5年次 補綴学臨床予備実習担当
    5年次 6年次 臨床実習担当

社会貢献・国際連携活動概要

  • 歯科医師をターゲットとしたインプラント治療に関する講演活動も積極的に行なっている。
    その他、留学の経験を踏まえて国際共同研究に関しても精力的に進行中である。

    歯科関連コメディカルへの教育活動も行っている。

海外渡航歴

  • 2014年3月 - 2020年3月

    滞在国名1:スウェーデン王国   滞在機関名1:スウェーデン・マルメ大学歯学部

学内運営に関わる各種委員・役職等

  • 2021年7月 - 2023年6月   その他 渉外委員会委員

  • 2020年6月 - 2024年7月   その他 国際委員会委員

  • 2012年9月 - 2014年2月   その他 学術委員会委員

専門診療領域

  • 生物系/医歯薬学/歯学/補綴理工系歯学

臨床医資格

  • 指導医

    日本補綴歯科学会

  • 認定医

    日本口腔インプラント学会

医師免許取得年

  • 2004年