Updated on 2024/11/11

Information

 

写真a

 
FUKUDA TAKAO
 
Organization
Kyushu University Hospital Periodontics Lecturer
School of Dentistry Department of Dentistry（Concurrent）
Graduate School of Dental Science （Concurrent）
Graduate School of Dental Science Department of Dental Science（Concurrent）
Title
Lecturer
Contact information
メールアドレス
Tel
0926426358
Profile
・研究活動 歯周炎における病態とその後に起こる歯周組織修復・再生を分子生物学レベルで解明する研究を行っている。 ・教育活動 歯学部４年生の臨床基礎実習における講義および指導、同５年生の臨床予備実習および臨床実習における指導、同６年生の臨床実習およびリサーチエクスポージャーにおける指導を行っている。 ・診療活動 九州大学病院歯周病科で、歯周病の治療を中心に、齲蝕の保存修復治療、歯髄炎・感染根管の治療を行っている。
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Degree

  • Doctor of Philosophy in Dentistry (Kyushu University)

Research Interests・Research Keywords

  • Research theme：New therapeutic strategies for periodontal disease using exosome from GMSCs

    Keyword：GMSC, exosome

    Research period： 2017.4

  • Research theme：The development of regenerative periodontal therapy targetting for the new amelogenin binding proteins

    Keyword：periodontal disease, regenerative therapy,　amelogenin

    Research period： 2008.4 - 2013.3

Awards

  • 日本歯周病学会学術賞

    2021.10   日本歯周病学会   題目「歯肉幹細胞由来エクソソームのM2マクロファアージ誘導を介した革新的歯周治療の開発」に関する一連の学術論文を発表し、国際的に評価される多大の成果を挙げたと日本歯周病学会から評価された。

  • 日本歯科保存学会奨励賞

    2014.6   日本歯科保存学会  

Papers

  • Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss Reviewed International journal

    122   306 - 324   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.actbio.2020.12.046.

    Other Link： https://www.sciencedirect.com/science/article/pii/S0006291X20318830

  • Grp78 Is Critical for Amelogenin-Induced Cell Migration in a Multipotent Clonal Human Periodontal Ligament Cell Line Reviewed International journal

    Kyousuke Toyoda, Takao Fukuda, Terukazu Sanui, Urara Tanaka, Kensuke Yamamichi, Ryo Atomura, Hidefumi Maeda, Atsushi Tomokiyo, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura

    Journal of Cellular Physiology   231 ( 2 )   414 - 427   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jcp.25087

  • Identification of Novel Amelogenin-Binding Proteins by Proteomics Analysis Reviewed International journal

    Takao Fukuda, Terukazu Sanui, Kyousuke Toyoda, Urara Tanaka, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura

    PLoS One   8 ( 10 )   2013.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0078129

  • Characterization of the 5′-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein Reviewed International journal

    32 ( 2 )   611 - 622   2004.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/nar/gkh223

  • Luteolin, chemical feature and potential use for oral disease

    Fukuda T., Kawakami K., Toyoda M., Hayashi C., Sanui T., Uchiumi T.

    Current Oral Health Reports   11 ( 4 )   290 - 296   2024.12

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    Publisher：Current Oral Health Reports  

    Purpose of Review: Luteolin, a natural polyphenolic flavone, is a bioactive compound with high thermal stability. Owing to its prominent antioxidant activity, luteolin has been reported to exert therapeutic effects on inflammation-associated diseases. This review discusses the therapeutic potential of luteolin for treating dental diseases. Recent Findings: Luteolin has multifaceted pharmacological activities, including anti-inflammatory, neuroprotective, anticancer, and cardioprotective effects. Furthermore, the antibacterial effects of luteolin are accompanied by an anti-biofilm effect. More recently, luteolin has been identified as an inhibitor of protein kinase R (PKR), which plays an essential role in inflammasome activation. In this regard, we demonstrated the potential of luteolin as a pulp sedation compound for pulpitis that acts by suppressing PKR-mediated inflammation in dental pulp cells. Summary: Although conventional dental treatments for dental caries or periodontitis largely depend on cause-related therapy, disruption of biofilms and regulation of inflammation are prerequisites for a favorable prognosis. Together with its superior anti-inflammatory and antibacterial effects, the biocompatible features of luteolin make it a promising candidate for treating dental diseases with fewer side effects.

    DOI： 10.1007/s40496-024-00389-w

    Scopus

  • An 84-Year-Old Man with a History of Myeloma and Biphosphonate-Related Osteonecrosis of the Jaw Treated with Preoperative Vascular Embolization Before Partial Maxillectomy

    Taketomi, T; Fukuda, T; Nojiri, J; Sanui, T

    AMERICAN JOURNAL OF CASE REPORTS   25   e943807   2024.7   （ eISSN:1941-5923 ）

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    Language：English   Publisher：American Journal of Case Reports  

    Objective: Rare disease Background: Bisphosphonates and anti-receptor activator of nuclear factor kappa B antibodies are used to treat bone diseases associated with increased osteoclast activity, including myeloma. However, they can cause osteonecrosis of the jaw, known as medication-related osteonecrosis of the jaw. This report presents a case of a patient with a history of myeloma who required posterior maxilla resection for bisphosphonate-related osteonecrosis of the jaw, in which preoperative embolization prevented unexpected bleeding related to vascular injury and allowed for a safe procedure with minimal bleeding. Case Report: An 84-year-old man presented to our department with a 3-year history of purulent drainage and bone exposure in the right maxilla. Based on the clinical findings at the initial visit, the clinical diagnosis was bisphosphonate-related osteonecrosis of the jaw, and the patient underwent a partial right maxillary osteotomy. This surgery was associated with a risk of unexpected bleeding from a branch of the maxillary artery during the posterior maxilla resection. A catheter-based embolization of the maxillary artery was performed the day before performing a partial maxillectomy to avoid unexpected bleeding risk. Thus, no abnormal bleeding occurred during partial maxillectomy, and no postoperative complications occurred for 3 years. Conclusions: In the surgical treatment of medication-related osteonecrosis of the jaw, preoperative vascular embolization of the peripheral maxillary artery beyond the middle meningeal artery bifurcation is a valuable technique for safe maxillectomy involving the posterior maxilla.

    DOI： 10.12659/AJCR.943807

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  • Therapeutic strategy for periodontitis using GMSCs-derived extracellular vesicles

    Fukuda Takao, Nishimura Fusanori

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)   66 ( 1 )   1 - 8   2024.3   （ ISSN:03850110 eISSN:1880408X ）

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    Language：Japanese   Publisher：JAPANESE SOCIETY OF PERIODONTOLOGY  

    DOI： 10.2329/perio.66.1

    CiNii Research

  • Scaffold-free bone-like 3D structure established through osteogenic differentiation from human gingiva-derived stem cells Reviewed International journal

    Masaaki Toyoda, Takao Fukuda, Ryota Fujimoto, Kentaro Kawakami, Chikako Hayashi, Yuki Nakao, Yukari Watanabe, Tsukasa Aoki, Miyu Shida, Terukazu Sanui, Masahide Taguchi, Kensuke Yamamichi, Ayami Okabe, Tatsunori Okada, Kyoko Oka,Koichi Nakayam, Fusanori Nishimura, Shunichi Kajioka

    Biochemistry and Biophysics Reports   38   101656   2024.2   （ ISSN:2405-5808 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrep.2024.101656

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  • Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation

    Kawakami Kentaro, Fukuda Takao, Toyoda Masaaki, Nakao Yuki, Hayashi Chikako, Watanabe Yukari, Aoki Tsukasa, Shinjo Takanori, Iwashita Misaki, Yamashita Akiko, Shida Miyu, Sanui Terukazu, Uchiumi Takeshi, Nishimura Fusanori

    BioMed Research International   2024   8864513   2024.1   （ ISSN:23146133 eISSN:23146141 ）

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    Language：English  

    Aim. The present study evaluated the therapeutic effects of luteolin in alleviating pulpitis of dental pulp- (DP-) derived microvesicles (MVs) via the inhibition of protein kinase R- (PKR-) mediated inflammation. Methodology. Proteomic analysis of immortalized human dental pulp (DP-1) cell-derived MVs was performed to identify PKR-associated molecules. The effect of luteolin on PKR phosphorylation in DP-1 cells and the expression of tumor necrosis factor-α (TNF-α) in THP-1 macrophage-like cells were validated. The effect of luteolin on cell proliferation was compared with that of chemical PKR inhibitors (C16 and 2-AP) and the unique commercially available sedative guaiacol-parachlorophenol. In the dog experimental pulpitis model, the pulps were treated with (1) saline, (2) guaiacol-parachlorophenol, and (3) luteolin. Sixteen teeth from four dogs were extracted, and the pulp tissues were analyzed using hematoxylin and eosin staining. Immunohistochemical staining was performed to analyze the expression of phosphorylated PKR (pPKR), myeloperoxidase (MPO), and CD68. Experimental endodontic-periodontal complex lesions were established in mouse molar through a silk ligature and simultaneous MV injection. MVs were prepared from DP-1 cells with or without pretreatment with 2-AP or luteolin. A three-dimensional microcomputed tomography analysis was performed on day 7 (n=6). Periodontal bone resorption volumes were calculated for each group (nonligated–ligated), and the ratio of bone volume to tissue volume was measured. Results. Proteomic analysis identified an endogenous PKR activator, and a protein activator of interferon-induced PKR, also known as PACT, was included in MVs. Luteolin inhibited the expressions of pPKR in DP-1 cells and TNF-α in THP-1 cells with the lowest suppression of cell proliferation. In the dog model of experimental pulpitis, luteolin treatment suppressed the expression of pPKR-, MPO-, and CD68-positive cells in pulp tissues, whereas guaiacol-parachlorophenol treatment caused coagulative necrosis and disruption. In a mouse model of endodontic-periodontal complex lesions, luteolin treatment significantly decreased MV-induced alveolar bone resorption. Conclusion. Luteolin is an effective and safe compound that inhibits PKR activation in DP-derived MVs, enabling pulp preservation.

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  • Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation

    Kawakami, K; Fukuda, T; Toyoda, M; Nakao, Y; Hayashi, C; Watanabe, Y; Aoki, T; Shinjo, T; Iwashita, M; Yamashita, A; Shida, M; Sanui, T; Uchiumi, T; Nishimura, F

    BIOMED RESEARCH INTERNATIONAL   2024   8864513   2024.1   （ ISSN:2314-6133 eISSN:2314-6141 ）

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    Language：English   Publisher：BioMed Research International  

    Aim. The present study evaluated the therapeutic effects of luteolin in alleviating pulpitis of dental pulp- (DP-) derived microvesicles (MVs) via the inhibition of protein kinase R- (PKR-) mediated inflammation. Methodology. Proteomic analysis of immortalized human dental pulp (DP-1) cell-derived MVs was performed to identify PKR-associated molecules. The effect of luteolin on PKR phosphorylation in DP-1 cells and the expression of tumor necrosis factor-α (TNF-α) in THP-1 macrophage-like cells were validated. The effect of luteolin on cell proliferation was compared with that of chemical PKR inhibitors (C16 and 2-AP) and the unique commercially available sedative guaiacol-parachlorophenol. In the dog experimental pulpitis model, the pulps were treated with (1) saline, (2) guaiacol-parachlorophenol, and (3) luteolin. Sixteen teeth from four dogs were extracted, and the pulp tissues were analyzed using hematoxylin and eosin staining. Immunohistochemical staining was performed to analyze the expression of phosphorylated PKR (pPKR), myeloperoxidase (MPO), and CD68. Experimental endodontic-periodontal complex lesions were established in mouse molar through a silk ligature and simultaneous MV injection. MVs were prepared from DP-1 cells with or without pretreatment with 2-AP or luteolin. A three-dimensional microcomputed tomography analysis was performed on day 7 (n=6). Periodontal bone resorption volumes were calculated for each group (nonligated-ligated), and the ratio of bone volume to tissue volume was measured. Results. Proteomic analysis identified an endogenous PKR activator, and a protein activator of interferon-induced PKR, also known as PACT, was included in MVs. Luteolin inhibited the expressions of pPKR in DP-1 cells and TNF-α in THP-1 cells with the lowest suppression of cell proliferation. In the dog model of experimental pulpitis, luteolin treatment suppressed the expression of pPKR-, MPO-, and CD68-positive cells in pulp tissues, whereas guaiacol-parachlorophenol treatment caused coagulative necrosis and disruption. In a mouse model of endodontic-periodontal complex lesions, luteolin treatment significantly decreased MV-induced alveolar bone resorption. Conclusion. Luteolin is an effective and safe compound that inhibits PKR activation in DP-derived MVs, enabling pulp preservation.

    DOI： 10.1155/2024/8864513

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  • Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation Reviewed International journal

    Kentaro Kawakami, Takao Fukuda, Masaaki Toyoda, Yuki Nakao, Chikako Hayashi, Yukari Watanabe, Tsukasa Watanabe, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Miyu Shida, Takaharu Taketomi, Terukazu Sanui, Takeshi Uchiumi, Fusanori Nishimura

    BioMed Research International   2024   8864513   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1155/2024/8864513.

    Other Link： https://www.hindawi.com/journals/bmri/2024/8864513/

  • Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development

    Imagawa Mio, Shinjo Takanori, Sato Kohei, Kawakami Kentaro, Zeze Tatsuro, Nishimura Yuki, Toyoda Masaaki, Chen Shuang, Ryo Naoaki, Ahmed Al-kafee, Iwashita Misaki, Yamashita Akiko, Fukuda Takao, Sanui Terukazu, Nishimura Fusanori

    Frontiers in Physiology   14   2023.12   （ eISSN:1664042X ）

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    Drug-induced gingival overgrowth (DIGO), induced by certain immunosuppressive drugs, antihypertensive agents, and antiepileptic drugs, may contribute to the formation of deeper periodontal pockets and intractableness in periodontitis. To date, multiple factors such as enhanced matrix production, inflammation, and reduced matrix degradation might be involved in the pathogenesis of DIGO. We have previously reported that SPOCK-1, a heparan sulfate proteoglycan, could affect gingival thickening by promoting epithelial-to-mesenchymal transition (EMT) in gingival keratinocytes. However, few studies have investigated whether a combination of these factors enhances the DIGO phenotype in animal models. Therefore, we investigated whether SPOCK-1, periodontal inflammation, and cyclosporin-A (CsA) could cooperatively promote gingival overgrowth. We first confirmed that Spock-1 overexpressing (Spock1-Tg) mice showed significantly thicker gingiva and greater alveolar bone loss than WT mice in response to ligature-induced experimental periodontitis. DIGO was induced by the combination of CsA administration and experimental periodontitis was significantly enhanced in Spock1-Tg mice compared to that in WT mice. Ligature-induced alveolar bone loss in CsA-treated Spock1-Tg mice was also significantly greater than that in CsA-treated WT mice, while being accompanied by an increase in Rankl and Col1a1 levels and a reduction in matrix metalloprotease expression. Lastly, SPOCK-1 promoted RANKL-induced osteoclast differentiation in both human peripheral blood mononuclear cells and murine macrophages, while peritoneal macrophages from Spock1-Tg mice showed less TNFα and IL-1β secretion than WT mice in response to Escherichia coli lipopolysaccharide. These results suggest that EMT, periodontal inflammation, and subsequent enhanced collagen production and reduced proteinase production contribute to CsA-induced DIGO pathogenesis.

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  • A Case of a Dentigerous Cyst in the Maxillary Sinus Treated Preoperatively With Vascular Embolization to Avoid Intraoperative Abnormal Bleeding

    Taketomi, T; Fukuda, T; Takeshita, G; Sanui, T

    CUREUS JOURNAL OF MEDICAL SCIENCE   15 ( 12 )   e50228   2023.12   （ ISSN:2168-8184 eISSN:2168-8184 ）

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  • Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development Reviewed International journal

    Mio Imagawa, Takanori Shinjo, Kohei Sato, Kentaro Kawakami, Tatsuro Zeze, Yuki Nishimura, Masaaki Toyoda, Shuang Chen, Naoaki Ryo, Al-kafee Ahmed, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura,

    Frontiers in Physiology   14   1298813   2023.12   （ ISSN:1664-042X eISSN:1664-042X ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fphys.2023.1298813

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  • A Case of a Dentigerous Cyst in the Maxillary Sinus Treated Preoperatively With Vascular Embolization to Avoid Intraoperative Abnormal Bleedin Reviewed International journal

    Takaharu Taketomi, Takao Fukuda, Terukazu Sanui

    Cureus   15 ( 12 )   e50228   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.7759/cureus.50228.

  • Endothelial Insulin Resistance Exacerbates Experimental Periodontitis Reviewed International journal

    Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Yuki Nishimura, Mio Imagawa, Shuang Chen, Al-kafee Ahmed, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Kyoungmin Park, George L King, Fusanori Nishimura,

    Journal of Dental Research   102 ( 10 )   1152 - 1161   2023.9   （ ISSN:0022-0345 eISSN:1544-0591 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/00220345231181539

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  • miR-582-5p targets<i> Skp1</i> and regulates NF-ΚB signaling-mediated inflammation

    Li, RZ; Sano, T; Mizokami, A; Fukuda, T; Shinjo, T; Iwashita, M; Yamashita, A; Sanui, T; Nakatsu, Y; Sotomaru, Y; Asano, T; Kanematsu, T; Nishimura, F

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   734   109501   2023.1   （ ISSN:0003-9861 eISSN:1096-0384 ）

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    Language：English   Publisher：Archives of Biochemistry and Biophysics  

    A well-tuned inflammatory response is crucial for an effective immune process. Nuclear factor-kappa B (NF-κB) is a key mediator of inflammatory and innate immunity responses, and its dysregulation is closely associated with immune-related diseases. MicroRNAs (miRNAs) are important inflammation modulators. However, miRNA-regulated mechanisms that implicate NF-κB activity are not fully understood. This study aimed to identify a potential miRNA that could modulate the dysregulated NF-κB signaling during inflammation. We identified miR-582-5p that was significantly downregulated in inflamed murine adipose tissues and RAW264.7 cells. S-phase kinase-associated protein 1 (SKP1), a core component of an E3 ubiquitin ligase that regulates the NF-κB pathway, was proposed as a biological target of miR-582-5p by using TargetScan. The binding of miR-582-5p to a 3′-untranslated region site on Skp1 was confirmed using a dual-luciferase reporter assay; in addition, transfection with a miR-582-5p mimic suppressed SKP1 expression in RAW264.7 cells. Importantly, exogenous miR-582-5p attenuated the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 through suppressing the degradation of the NF-κB inhibitor alpha, followed by the nuclear translocation of NF-κB. Therefore, exogenously applied miR-582-5p can attenuate the NF-κB signaling pathway via targeting Skp1; this provides a prospective therapeutic strategy for treating inflammatory and immune diseases.

    DOI： 10.1016/j.abb.2022.109501

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  • miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation. Reviewed International journal

    734   109501   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.abb.2022.109501.

    Other Link： https://www.sciencedirect.com/science/article/pii/S0003986122003873?via%3Dihub

  • Development of a novel therapeutic approach for periodontitis that utilizes GMSCs-derived exosome through induction of M2 macrophage

    Fukuda Takao

    Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)   64 ( 4 )   109 - 115   2022.12   （ ISSN:03850110 eISSN:1880408X ）

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    Language：Japanese   Publisher：JAPANESE SOCIETY OF PERIODONTOLOGY  

    <p>Periodontitis is one of the most common osteolytic inflammatory diseases in humans. Formation of a periodontal bacteria-associated biofilm is thought to be a trigger for the development of periodontitis, but it is not believed to be sufficient by itself to sustain the disease, as compromise of the host immune response is critical for inflammatory tissue breakdown and disease progression. Macrophages play an important role in the immune response both during the initiation and resolution of the inflammation. Macrophages are broadly classified into two phenotypes, pro-inflammatory M1 and wound-healing M2 cells. Since M2 macrophages contribute to the tissue-remodeling process, effective M2 macrophage induction would provide a favorable environment for resolution of the inflammation and tissue regeneration.</p><p>Mesenchymal stem cell (MSCs) have been applied for the purpose of inducing tissue regeneration and treating autoimmune disorders. Specifically, MSC-derived exosomes have attracted much attention for cell-free MSC therapy, because of their ability to transport vesicular cargo molecules, including growth factors and regulatory miRNAs, which mediate cell-to-cell communication. As compared with other somatic MSCs, gingival tissue-derived MSCs (GMSCs) have the unique capacity for pronounced immunoregulation and secrete large amount of exosomes. Recent studies have indicated that appropriate preconditioning of MSCs with disease-related stimuli can optimize the contents of the exosomes to efficiently support the repair of specific diseases.</p><p>In this review, we report the therapeutic effects of TNF-α-preconditioned-GMSC-derived exosomes on periodontal disease and discuss the underlying molecular mechanisms. Our study revealed that TNF-α-enhanced exosomal CD73 expression leading to anti-inflammatory M2 macrophage polarization and exosomal miR-1260b is an important negative regulator of osteoclastogenesis. Accordingly, our findings may pave the way for the development of a novel therapeutic strategy for patients with periodontitis.</p>

    DOI： 10.2329/perio.64.109

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  • miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress

    Hayashi, C; Fukuda, T; Kawakami, K; Toyoda, M; Nakao, Y; Watanabe, Y; Shinjo, T; Sano, T; Iwashita, M; Yotsumoto, K; Shida, M; Taketomi, T; Sanui, T; Uchiumi, T; Kanematsu, T; Nishimura, F

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   10   2022.11   （ ISSN:2296-634X ）

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  • miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress Reviewed International journal

    Chikako Hayashi, Takao Fukuda, Kentaro Kawakami, Masaaki Toyoda, Yuki Nakao, Yukari Watanabe, Takanori Shinjo, Tomomi Sano, Misaki Iwashita, Karen Yotsumoto, Miyu Shida, Takaharu Taketomi, Terukazu Sanui, Takeshi Uchiumi, Takashi Kanematsu, Fusanori Nishimura

    Frontiers in Cell and Developmental Biology   10   1061216   2022.11   （ ISSN:2296-634X eISSN:2296634X ）

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    The expression profiles of exosomal microRNAs (miRNAs) are regulated by the microenvironment, and appropriate priming with mesenchymal stem cells (MSCs) is one of the strategies to enhance the paracrine potency of MSCs. Our previous work demonstrated that exosomes from tumor necrosis factor (TNF)-α-primed human gingiva-derived MSCs (GMSCs) could be a therapeutic tool against periodontitis, and that TNFα-inducible exosomal miR-1260b is essential for the inhibition of alveolar bone loss. However, the precise molecular mechanism underlying miR-1260b-mediated inhibition of osteoclastogenesis is not yet fully understood. Here, we found that the activating transcription factor (ATF)-6β, a novel miR-1260b-targeting gene, is critical for the regulation of osteoclastogenesis under endoplasmic reticulum (ER) stress. An experimental periodontal mouse model demonstrated that induction of ER stress was accompanied by enhanced ATF6β expression, and local administration of miR-1260b and ATF6β siRNA using polyethylenimine nanoparticles (PEI-NPs) significantly suppressed the periodontal bone resorption. In periodontal ligament (PDL) cells, the ER stress inducer, tunicamycin, enhanced the expression of the receptor activator of NF-κB ligand (RANKL), while miR-1260b-mediated downregulation of ATF6β caused RANKL inhibition. Furthermore, the secretome from miR-1260b/ATF6β-axis-activated PDL cells inhibited osteoclastogenesis in human CD14^+ peripheral blood-derived monocytes. These results indicate that the miR-1260b/ATF6β axis mediates the regulation of ER stress, which may be used as a novel therapeutic strategy to treat periodontal disease.

    DOI： 10.3389/fcell.2022.1061216

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    Other Link： https://www.frontiersin.org/articles/10.3389/fcell.2022.1061216/full

  • Basal cell adenoma of the minor salivary glands in the buccal mucosa: A case report and literature review Reviewed International journal

    Takaharu Taketomi, Ken Nakamura, Terukazu Sanui, Takao Fukuda, Yukiko Tominaga, Yukari Takase, Jingo Kusukawa

    Oral and Maxillofacial Surgery Cases   8 ( 3 )   100276   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.omsc.2022.100276

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    Other Link： https://www.sciencedirect.com/science/article/pii/S2214541922000359?via%3Dihub

  • Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression

    Watanabe Yukari, Fukuda Takao, Hayashi Chikako, Nakao Yuki, Toyoda Masaaki, Kawakami Kentaro, Shinjo Takanori, Iwashita Misaki, Yamato Hiroaki, Yotsumoto Karen, Taketomi Takaharu, Uchiumi Takeshi, Sanui Terukazu, Nishimura Fusanori

    Scientific Reports   12 ( 1 )   13344   2022.8   （ ISSN:2045-2322 eISSN:20452322 ）

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    Immunoregulatory properties of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique immunoregulatory capacity and secrete large amounts of EVs. Recent findings suggest that priming MSCs with inflammatory stimuli is an effective strategy for cell-free therapy. However, the precise mechanism by which the contents of EVs are customized has not been fully elucidated. Here, we show that EVs derived from GMSCs primed with a combination of two pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interferon-α (IFN-α), synergistically promote anti-inflammatory M2 macrophage polarization by increasing the expression of cluster of differentiation 73 (CD73) and CD5 molecule-like (CD5L). Expression of CD73 by TNF-α/IFN-α stimulation was transcriptionally upregulated by the activation of mammalian target of rapamycin signaling and nuclear translocation of hypoxia-inducible factor 1α in GMSCs. TNF-α/IFN-α treatment also significantly increased the expression of CD5L mRNA via the transcription factor DNA-binding protein inhibitor ID3 and liver X receptor. Interestingly, exosomal CD5L is a prerequisite for the synergistic effect of EVs-mediated M2 macrophage polarization. These results indicate that combined pre-licensing with TNF-α and IFN-α in GMSCs is ideal for enhancing the anti-inflammatory function of EVs, which contributes to the establishment of a therapeutic tool.

    DOI： 10.1038/s41598-022-17692-0

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  • Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression Reviewed International journal

    12 ( 1 )   13344   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-022-17692-0.

    Other Link： https://www.nature.com/articles/s41598-022-17692-0

  • XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis Reviewed International journal

    Nishimura, Y; Iwashita, M; Hayashi, M; Shinjo, T; Watanabe, Y; Zeze, T; Yamashita, A; Fukuda, T; Sanui, T; Sano, T; Asano, T; Nishimura, F

    ACTA DIABETOLOGICA   59 ( 10 )   1275 - 1286   2022.7   （ ISSN:0940-5429 eISSN:1432-5233 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Acta Diabetologica  

    Aims: Pancreatic β-cell apoptosis may be involved in the onset and progression of type 2 diabetes mellitus, although its mechanism remains unclear. We previously demonstrated that macrophage-derived interferon (IFN) β induced X-linked inhibitor of apoptosis–associated factor 1 (XAF1) expression in β-cells and accelerated β-cell apoptosis in vitro. Here, we explored the effects of XAF1 on β-cell function and progression of diabetes in vivo. Methods: Pancreatic β-cell-selective XAF1 overexpressing (Xaf1 Tg) mice were generated. Xaf1 Tg mice and their wild-type (WT) littermates were fed either a normal diet or a 40% or 60% high-fat diet (HFD). The effects of β-cell XAF1 on β-cell apoptosis and exacerbation of diabetes were investigated. Results: Palmitic acid induced IFNβ expression in macrophages, and HFD intake promoted macrophage infiltration in pancreatic islets, both of which cooperatively upregulated XAF1 expression in mouse islets. Furthermore, HFD-fed Xaf1 Tg mice demonstrated increased β-cell apoptosis, lowered insulin expression, and impaired glucose tolerance compared with WT mice fed the same diet. These effects were more pronounced in the 60%HFD group than in the 40%HFD group. Conclusions: Pancreatic β-cell XAF1 expression was enhanced via HFD-induced, macrophage-derived IFNβ, which promoted β-cell apoptosis and led to a reduction in insulin secretion and progression of diabetes. To our knowledge, this is the first report to demonstrate an association between pancreatic β-cell XAF1 overexpression and exacerbation of diabetes, thus providing insight into the mechanism of β-cell mass reduction in diabetes.

    DOI： 10.1007/s00592-022-01930-y

    Web of Science

    Scopus

    PubMed

    Other Link： https://link.springer.com/article/10.1007/s00592-022-01930-y

  • Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain Reviewed International journal

    Masato Hayashi, Misaki Iwashita, Yuki Nishimura, Takanori Shinjo, Tomomi Sano, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomoichiro Asano, Fusanori Nishimura

    BMJ Open Diabetes Research and Care   9 ( 1 )   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/bmjdrc-2020-001871

  • Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells Reviewed International journal

    Hiroaki Yamato, Terukazu Sanui, Karen Yotsumoto, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Ryosuke Aihara, Misaki Iwashita, Urara Tanaka, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura.

    Journal of Cellular Biochemistry   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jcb.29903

    Other Link： https://www.sciencedirect.com/science/article/pii/S0006291X20318830

  • SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism Reviewed International journal

    Rehab Alshargabi, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Tomomi Sano, Yuki Nishimura, Masato Hayashi, Tatsuro Zeze, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.

    Biochem Biophys Res Commun.   533 ( 4 )   1076 - 1082   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2020.09.129.

    Other Link： https://www.sciencedirect.com/science/article/pii/S0006291X20318830

  • SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth Reviewed International journal

    Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Aiko Takano, Taiki Sanada, Misaki Iwashita, Takanori Shinjo, Takao Fukuda, Terukazu Sanui, Shosei Kishida, Fusanori Nishimura

    Scientific Reports   10 ( 1 )   9785   2020.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-020-66660-z

  • Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages Reviewed International journal

    Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura

    Frontiers in immunology   10 ( 11 )   709   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2020.00709

  • Ccr7 Null Mice Are Protected Against Diet-Induced Obesity via Ucp1 Upregulation and Enhanced Energy Expenditure Reviewed International journal

    Tomomi Sano, Taiki Sanada, YUsuke Sotomaru, Takanori Shinjyo, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Takanori Shinjo, Terukazu Sanui, Tomoichiro Asano, Takashi Kanematsu, Fusanori Nishimura

    Nutrition & metabolism   69   2019.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12986-019-0372-5.

  • Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles Invited Reviewed International journal

    9 ( 1 )   2019.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-019-40046-2

  • Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways Reviewed International journal

    @Takaharu Taketomi, Tomohiro Onimura, @Daigo Yoshiga, Daichi Muratsu, @Terukazu Sanui, @Takao Fukuda, @Jingo Kusukawa, Seiji Nakamura

    Cell Biology International   42 ( 9 )   1106 - 1114   2018.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cbin.10876. Epub 2017 Oct 12.

  • Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway Reviewed International journal

    Kensuke Yamamichi, Takao Fukuda, Terukazu Sanui, Kyousuke Toyoda, Urara Tanaka, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura

    Archives of Oral Biology   83   241 - 251   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.archoralbio.2017.08.005

  • Sprouty2 Inhibition Resolves Inflammation in Periodontal Disease and Creates a Suitable Environment for Periodontal Tissue Regeneration Reviewed International journal

    Sanui Terukazu, Fukuda Takao, Tanaka Urara, Toyoda Kyosuke, Yotsumoto Karen, Nakao Yuki, Yamato Hiroaki, Taketomi Takaharu, Nishimura Fusanori

    Journal of Cell Biology & Immunology   1 ( 1 )   101 - 101   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Roles of serum in innate immune responses of human leukocytes to synthetic lipopeptide Reviewed International journal

    Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura

    International Immunopharmacology   50   61 - 68   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.intimp.2017.06.006

  • Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways Reviewed International journal

    Takaharu Taketomi, Tomohiro Onimura, Daigo Yoshiga, Daichi Muratsu, Terukazu Sanui, Takao Fukuda, Jingo Kusukawa, Seiji Nakamura

    Cell Biology International   in press   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cbin.10876

  • Adhesion attenuates respiratory burst induced by different modes of triggering in resting or LPS-primed neutrophils Reviewed International journal

    Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura

    Immunobiology   222 ( 8-9 )   865 - 871   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.imbio.2017.05.001

  • Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation Reviewed International journal

    Aiko Takano, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Etsuko Matsuzaki, Kensuke Yamamichi, Masaaki Takeshita, Terukazu Sanui, Fusanori Nishimura

    Metabolism: Clinical and Experimental   69   157 - 170   2017.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.metabol.2017.01.006

  • Microarray analysis of the effects of amelogenin on U937 monocytic cells Reviewed International journal

    Sanui Terukazu, Fukuda Takao, Yamamichi Kensuke, Toyoda Kyosuke, Tanaka Urara, Yotsumoto Karen, Taketomi Takaharu, Nishimura Fusanori

    American Journal of Molecular Biology   7 ( 2 )   107 - 122   2017.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.4236/ajmb.2017.72009

  • Anti-CD14 Antibody-treated Neutrophils Respond to LPS Possible Involvement of CD14 Upregulated by Anti-CD14 Antibody Binding Reviewed International journal

    Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Akira Haraguchi, Yoshitomi Aida, Fusanori Nishimura

    Immunological Investigations   46 ( 2 )   190 - 200   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/08820139.2016.1238925

  • Innate immune-stimulatory activity of Porphyromonas gingivalis fimbriae is eliminated by phase separation using Triton X-114 Reviewed International journal

    Kohji Nozoe, Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Akira Haraguchi, Yoshitomi Aida, Fusanori Nishimura

    Journal of Immunological Methods   441   31 - 38   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jim.2016.11.012

  • Glucose-Regulated Protein 78: A Novel Therapeutic Target for Amelogenin- Induced Periodontal Tissue Regeneration Reviewed International journal

    Fukuda Takao, Sanui Terukazu, Toyoda Kyosuke, Tanaka Urara, Yamamichi Kensuke, Taketomi Takaharu, Nishimura Fusanori

    Single Cell Biology   5 ( 2 )   137   2016.11

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.4172/2168-9431.1000137

  • Antibiotic effects against periodontal bacteria in organ cultured tissue Reviewed International journal

    Masaaki Takeshita, Akira Haraguchi, Mayumi Miura, Takafumi Hamachi, Takao Fukuda, Terukazu Sanui, Aiko Takano, Fusanori Nishimura

    Clinical and Experimental Dental Research   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • New Therapeutic Strategy for Regenerating Periodontal Tissue Based on the Combination of Amelogenin and Reapplications of Existing Grp78 Inducer. Reviewed International journal

    Fukuda Takao, Sanui Terukazu, Toyoda Keisuke, Tanaka Urara, Yamamichi Kensuke, Taketomi Takaharu, Nishimura Fusanori

    Journal of Cell Signaling   1 ( 3 )   118   2016.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.4172/jcs.1000118

  • Mechanisms of the Macrolide-Induced Inhibition of Superoxide Generation by Neutrophils Reviewed

    Kohji Nozoe, Yoshitomi Aida, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura

    Inflammation   39 ( 3 )   1039 - 1048   2016.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10753-016-0333-3

  • Biological Effects of Sprouty2 Inhibition in Periodontal Ligament Cells Reviewed International journal

    Sanui Terukazu, Fukuda Takao, Tanaka Urara, Toyoda Kyosuke, Yamamichi Kensuke, Taketomi Takaharu, Nishimura Fusanori

    Journal of Cell Signaling   1 ( 3 )   117   2016.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.4172/jcs.1000117

  • Disaggregation of lipopolysaccharide by albumin, hemoglobin or high-density lipoprotein, forming complexes that prime neutrophils for enhanced release of superoxide Reviewed International journal

    Toshiya Komatsu, Yoshitomi Aida, Takao Fukuda, Terukazu Sanui, Shunji Hiratsuka, Michael J. Pabst, Fusanori Nishimura

    Pathogens and Disease   74 ( 3 )   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/femspd/ftw003

  • Inhibition of Sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide. Invited Reviewed International journal

    26 ( 4 )   98 - 110   2016.2

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/iid3.99

  • Sprouty2 inhibition promotes proliferation and migration of periodontal ligament cells Reviewed International journal

    Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyousuke Toyoda, T. Taketomi, R. Atomura, K. Yamamichi, Hidefumi Maeda, Fusanori Nishimura

    Oral Diseases   21 ( 8 )   977 - 986   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/odi.12369

  • Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts but Inhibits Proliferation of Gingival Epithelial Cells Reviewed International journal

    Terukazu Sanui, Urara Tanaka, Takao Fukuda, Kyousuke Toyoda, Takaharu Taketomi, Ryo Atomura, Kensuke Yamamichi, Fusanori Nishimura

    Journal of Cellular Biochemistry   116 ( 4 )   628 - 639   2015.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jcb.25014

  • Spry2 is a novel therapeutic target for periodontal tissue regeneration through fibroblast growth factor receptor signaling and epidermal growth factor signaling Reviewed International journal

    Sanui Terukazu, Fukuda Takao, Tanaka Urara, Toyoda Kyousuke, Taketomi Takaharu, Nishimura Fusanori

    Receptors & Clinical Investigation   628 - 639   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.14800/rci.597

  • YB-1 is important for an early stage embryonic development Neural tube formation and cell proliferation Reviewed International journal

    Takeshi Uchiumi, Abbas Fotovati, Takakazu Sasaguri, Kohtaro Shibahara, Tatsuo Shimada, Takao Fukuda, Takanori Nakamura, Hiroto Izumi, Teruhisa Tsuzuki, Michihiko Kuwano, Kimitoshi Kohno

    Journal of Biological Chemistry   281 ( 52 )   40440 - 40449   2006.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M605948200

  • Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C Reviewed International journal

    Kotaro Shibahara, Takeshi Uchiumi, Takao Fukuda, Shinobu Kura, Yohei Tominaga, Yoshihiko Maehara, Kimitoshi Kohno, Yusaku Nakabeppu, Teruhisa Tsuzuki, Michihiko Kuwano

    Cancer Science   95 ( 4 )   348 - 353   2004.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1349-7006.2004.tb03214.x

  • Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine Reviewed International journal

    Hiroshi Hayakawa, Takeshi Uchiumi, Takao Fukuda, Megumi Ashizuka, Kimitoshi Kohno, Michihiko Kuwano, Mutsuo Sekiguchi

    Biochemistry   41 ( 42 )   12739 - 12744   2002.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/bi0201872

  • Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 Reviewed International journal

    Megumi Ashizuka, Takao Fukuda, Takanori Nakamura, Kanemitsu Shirasuna, Kazuhiro Iwai, Hiroto Izumi, Kimitoshi Kohno, Michihiko Kuwano, Takeshi Uchiumi

    Molecular and Cellular Biology   22 ( 18 )   6375 - 6383   2002.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/MCB.22.18.6375-6383.2002

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Books

  • 幹細胞由来EV~治療,診断,化粧品への展開~第2回 歯肉幹細胞由来エクソソームを応用した歯周炎治療の開発に向けて

    福田 隆男

    和光純薬時報　巻： 90 号： 4 ページ： 10-11 発行年： 2022年10月15日  2022 

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    Total pages：28  

    CiNii Research

  • 「Y-box結合タンパク質の骨芽細胞における動態解析」　歯界展望　特別号2013

    福田 隆男, 田中 麗, 豊田 敬介, 讃井 彰一, 武富 孝治, 後村 亮, 濱地 貴文, 西村 英紀, 前田 勝正（ Role： Joint author）

    医歯薬出版株式会社  2013.5 

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    Language：Japanese   Book type：Scholarly book

  • 「bFGFシグナルのアンタゴニストを標的とした歯周組織再生療法の開発」　歯界展望　特別号2013

    讃井 彰一, 田中 麗, 豊田 敬介, 福田 隆男, 後村 亮, 濱地 貴文, 前田 勝正（ Role： Joint author）

    医歯薬出版株式会社  2013.5 

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    Language：Japanese   Book type：Scholarly book

  • 「歯周組織細胞群における新規アメロジェニン結合タンパク質のプロテオーム解析」　歯界展望　特別号2013

    田中 麗, 豊田 敬介, 福田 隆男, 讃井 彰一, 後村 亮, 濱地 貴文, 前田 勝正（ Role： Joint author）

    医歯薬出版株式会社  2013.5 

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    Language：Japanese   Book type：Scholarly book

Presentations

  • Fabrication of Gingiva-Derived Stem Cell-Based Scaffold-Free Bone-Like 3D Structures International conference

    Masaaki Toyoda, Shunichi Kajioka, Takao Fukuda, Kentaro Kawakami, Miyu Shida, Chikako Hayashi, Tsukasa Aoki, Tatsuro Zeze, Yuki Nakao, Terukazu Sanui, Fusanori Nishimura

    2024 IADR/AADOCR/CADR General Session & Exhibition  2024.3 

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    Event date： 2024.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • MiR-1260b Promotes M2 Macrophage Polarization by Targeting NFAT5 and NLRP3 International conference

    Chikako Hayashi, Masaaki Toyoda, Kentaro Kawakami, Yuki Nakao, Miyu Shida, Takanori Shinjo, Terukazu Sanui, Takao Fukuda, Fusanori Nishimura

    2024 IADR/AADOCR/CADR General Session & Exhibition  2024.3 

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    Event date： 2024.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • バイオ３Dプリンターを用いた歯肉幹細胞由来骨様立体構造物の作製方法の確立と骨分化能、石灰化度に関する解析.

    豊田真顕、梶岡俊一、福田隆男、川上賢太郎、信太実有、李金鳳、林千華子、中尾雄紀、讃井彰一、西村英紀

    第９回細胞凝集研究会  2023.12 

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    Event date： 2023.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：佐賀アバンセホール   Country：Japan  

  • バイオ３Dプリンターを用いた歯肉幹細胞由来骨様立体構造物の作製方法の確立と骨分化能、石灰化度に関する解析

    豊田真顕、梶岡俊一、福田隆男、川上賢太郎、信太実有、李金鳳、林千華子、中尾雄紀、讃井彰一、西村英紀,

    第66回秋季日本歯周病学会学術大会  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：出島メッセ長崎   Country：Japan  

  • miR-582-5p, that targets Skp1 and suppresses NF-kB signaling-mediated inflammation, is down-regulated in periodontitis and obesity.

    Li Rongzhi, Tomomi Sano, Takao Fukuda, Takanori Shinjyo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Fusanori Nishimura.

    2023.6 

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    Event date： 2023.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 歯肉幹細胞由来エクソソームを応用した歯周炎治療の開発に向けて Invited

    福田隆男

    第45回日本分子生物学会  2022.12 

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    Event date： 2022.11 - 2022.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：幕張メッセ   Country：Japan  

  • バイオ３Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦

    豊田真顕、梶岡俊一 、川上賢太郎 、林千華子 、渡邊ゆかり 、中尾雄紀 、四本かれん 、讃井彰一 、福田隆男 、西村英紀

    令和4年度日本歯周病学会九州五大学 日本臨床歯周病学会九州支部合同研修会  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長崎県歯科医師会館   Country：Japan  

  • ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて

    7. 川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀　ヒ川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀

    2022年度日本歯科保存学会秋季学術大会(第157回)  2022.11 

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    Event date： 2022.11 - 2022.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：岡山コンベンションセンター   Country：Japan  

  • miR-1260b inhibits periodontal bone loss by targeting ATF6β. International conference

    2022.10 

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    Event date： 2022.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Phoenix Convention Center   Country：United States  

  • Endothelial insulin resistance contributes to the exacerbation of diabetes-related periodontitis International conference

    Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.

    The 108th Annual Meeting of the American Academy of Periodontology  2022.10 

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    Event date： 2022.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • Fabrication of stem cell-based scaffold-free bone-like 3D structures. International conference

    Toyoda M, Kajioka S, Fujimoto R, Hayashi C, Kawakami K, Watanabe Y, Nakao Y, Yotsumoto K, Sanui T, Fukuda T, Nakayama K, Nishimura. F.

    The 108th Annual Meeting of the American Academy of Periodontology  2022.10 

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    Event date： 2022.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • Endothelial insulin resistance contributes to the pathogenesis of diabetes-related periodontitis. International conference

    Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.

    2022 IADR/APR General Session & Exhibition  2022.6 

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    Event date： 2022.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 歯肉幹細胞由来エクソソームのM2マクロファージ誘導を介した革新的歯周治療の開発 Invited

    福田隆男

    第65回春季日本歯周病学会学術大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：京王プラザホテル   Country：Japan  

  • TNF-α/IFN-α共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する

    渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、中尾雄紀、大和寛明、四本かれん、新城尊徳、岩下未咲、讃井彰一、福田隆男、西村英紀

    2022年度日本歯科保存学会春季学術大会(第156回)  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Web開催   Country：Japan  

  • 間葉系幹細胞からの骨様立法構造物作製への挑戦

    豊田真顕、梶岡俊一、福田隆男、渡辺ゆかり、林千華子、川上賢太郎、中尾雄紀、四本かれん、大和寛明、讃井彰一、西村英紀

    第65回春季日本歯周病学会学術大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京王プラザホテル   Country：Japan  

  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果

    林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀

    第65回春季日本歯周病学会学術大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京王プラザホテル   Country：Japan  

  • ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて

    川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀

    2022年度日本歯科保存学会春季学術大会(第156回)  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Web開催   Country：Japan  

  • Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress International conference

    2021.11 

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    Event date： 2021.11

    Language：English   Presentation type：Oral presentation (general)  

    Venue：福岡市   Country：Japan  

  • Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. International conference

    2021.11 

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    Event date： 2021.11

    Language：English   Presentation type：Oral presentation (general)  

    Venue：福岡市   Country：Japan  

  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用

    林千華子, 福田隆男, 渡邊ゆかり, 川上賢太郎, 豊田真顕, 中尾雄紀, 四本かれん， 大和寛明，新城尊徳，讃井彰一，西村英紀

    2021年度日本歯科保存学会秋季学術大会(第155回)  2021.10 

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    Event date： 2021.10 - 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Web開催   Country：Japan  

  • Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress International conference

    2021.10 

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    Event date： 2021.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡市   Country：Japan  

  • High-fat diet-induced XAF1 exacerbates diabetes by promoting pancreatic β-cell apoptosis International conference

    2021.10 

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    Event date： 2021.10

    Language：English   Presentation type：Oral presentation (general)  

    Venue：福岡市   Country：Japan  

  • Exosomes derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression International conference

    2021.10 

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    Event date： 2021.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡市   Country：Japan  

  • ゲラニルゲラニルアセトンとアメロジェニンの歯周組織再生への複合的効果

    大和寛明、讃井彰一、四本かれん、中尾雄紀、渡邊ゆかり、林千華子、相原良亮、岩下未咲、田中麗、福田隆男、西村英紀

    2021年度日本歯科保存学会春季学術大会(第154回)  2021.5 

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    Event date： 2021.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：Web開催   Country：Japan  

  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用

    林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀

    第64回春季日本歯周病学会学術大会  2021.5 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Exosomes from TNF-α-treated human gingiva-derived MSCs inhibit periodontal bone loss via miR-1260b-mediated RANKL inhibition International conference

    2020.11 

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    Event date： 2020.11

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Virtual Meeting   Country：Japan  

  • Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells. International conference

    Hiroaki Yamato, Terukazu Sanui, Karen Yotsumoto, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takao Fukuda, Urara Tanaka, Fusanori Nishimura.

    American Academy of Periodontology (AAP), 106th Annual meeting  2020.11 

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    Event date： 2020.11

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Amelogenin suppresses IFNγ-induced MHC class II expression in macrophages International conference

    2020.11 

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    Event date： 2020.11

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Therapeutic potential of exosomes derived from GMSCs in periodontal disease International conference

    Yuki Nakao, Takao Fukuda, Yukari Watanabe, Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjyo, Urara Tanaka, Terukazu Sanui, Fusanori Nishimura.

    American Academy of Periodontology (AAP), 106th Annual meeting  2020.11 

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    Event date： 2020.11

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Amelogenin down-regulates MHC class II antigen presentation on macrophages International conference

    Karen Yotsumoto, Terukazu Sanui, Hiroaki Yamato, Urara Tanaka, Yuki Nakao, Chikako Hayashi, Hiroaki Yamato, Yukari Watanabe, Takao Fukuda, Fusanori Nishimura

    JADR, The 68th annual meeting  2020.11 

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    Event date： 2020.11

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • SPOCK-1 is a novel epithelial mesenchymal transition (EMT) inducer in drug induced gingival overgrowth. International conference

    Korean Academy of Periodontology (KAP)  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Korea, Republic of  

  • 胃潰瘍治療薬テプレノンとアメロジェニンによる歯周組織再生誘導の可能性

    大和 寛明，讃井 彰一，四本 かれん, 中尾 雄紀，渡邊 ゆかり，福田 隆男，田中 麗， 西村 英紀

    令和元年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：アクロス福岡   Country：Japan  

  • アメロジェニンはマクロファージによるIFNγ誘導性MHCクラスⅡの抗原提示を抑制する

    四本かれん, 田中 麗，讃井 彰一，大和 寛明，中尾 雄紀，渡邊 ゆかり，林千華子, 福田 隆男，西村 英紀

    令和元年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：アクロス福岡   Country：Japan  

  • 歯肉幹細胞由来エクソソームによる炎症制御 Invited

    福田 隆男

    第151回秋季日本歯科保存学会 2019年度秋季学術大会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：福岡国際会議場   Country：Japan  

  • 歯肉幹細胞由来エクソソーム由来 miR-1260bはWnt5aを介して歯根膜細胞におけるRANKL発現を抑制する

    中尾 雄紀，福田 隆男，渡邊 ゆかり，林千華子, 四本 かれん,大和 寛明， 田中 麗，讃井 彰一，西村 英紀

    第151回秋季日本歯科保存学会 2019年度秋季学術大会  2019.11 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡国際会議場   Country：Japan  

  • アメロジェニンはマクロファージにおけるIFNγ誘導性MHCクラスⅡ分子の発現を抑制する

    四本 かれん, 田中 麗，讃井 彰一，大和 寛明，中尾 雄紀，渡邊 ゆかり，林千華子, 福田 隆男, 西村 英紀

    第62回秋季日本歯周病学会学術大会  2019.10 

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    Event date： 2019.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：西日本総合展示場・北九州国際会議場   Country：Japan  

  • アメロジェニンおよび胃潰瘍治療薬テプレノンが歯根膜細胞機能に与える影響

    大和 寛明，讃井 彰一， 四本 かれん, 中尾 雄紀，渡邊 ゆかり，福田 隆男，田中 麗， 西村 英紀

    第150回日本歯科保存学会2019年度春季学術大会  2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石川県立音楽堂   Country：Japan  

  • アメロジェニンはマクロファージによる抗原提示を抑制させる

    四本 かれん, 田中 麗，讃井 彰一，大和 寛明，中尾 雄紀，渡邊 ゆかり，福田 隆男, 西村 英紀

    第150回日本歯科保存学会2019年度春季学術大会  2019.6 

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：石川県立音楽堂   Country：Japan  

  • SPOCK-1 upregulation is a novel epithelial mesenchymal transition（EMT）inducer in calcium channel blocker-induced gingival overgrowth

    Alshargabi Yahya Fara Sallam Rehab，Tomomi Sano，Akiko Yamashita， Misaki Iwashita, Taiki Sanada，Takao Fukuda, Terukazu Sanui, Fusanori Nishimura

    第62回 日本歯周病学会春季学術大会  2019.5 

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：神奈川県民ホール   Country：Japan  

  • 歯肉幹細胞由来エクソソームは歯根膜細胞のRANKL発現を抑制する

    中尾 雄紀，福田 隆男，讃井 彰一，田中 麗，渡邊 ゆかり，大和 寛明， 四本 かれん, 西村 英紀

    第62回 日本歯周病学会春季学術大会  2019.5 

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    Event date： 2019.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：神奈川県民ホール   Country：Japan  

  • SPOCK-1 is a novel epithelial mesenchymal transition (EMT) inducer in calcium channel blocker-induced gingival overgrowth. International conference

    Kyudai Oral Bioscience & OBT Research Center Joint International Symposium  2019.3 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • 歯周組織再生療法の変遷と展望 Invited

    福田隆男

    日本歯周病学会第 1 回佐賀地区臨床研修会  2019.2 

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    Event date： 2019.2

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：佐賀県歯科医師会館   Country：Japan  

  • 歯肉幹細胞由来エクソソームによる抗炎症性マクロファージ誘導機序の検討

    #中尾 雄紀,@福田 隆男, @讃井 彰一, @田中 麗, #渡邊 ゆかり、#大和 寛明、#四本 かれん、@西村 英紀

    平成30年度日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研修会  2018.11 

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    Event date： 2018.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：アクロス福岡   Country：Japan  

  • 歯肉幹細胞由来エクソソームによる抗炎症性マクロファージ誘導機序の検討

    #中尾 雄紀,@福田 隆男, @讃井 彰一, @田中 麗, #渡邊 ゆかり、#大和 寛明、#四本 かれん、@西村 英紀

    第61回秋季日本歯周病学会学術大会  2018.10 

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    Event date： 2018.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：リーガロイヤルホテル大阪   Country：Japan  

  • 炎症脂肪/歯周組織における抗炎症分子の検索研究

    眞田 大樹, 佐野 朋美, 福田 隆男, 岩下 未咲, 山下 明子, 藤田 剛, 讃井 彰一, 栗原 英見, 西村 英紀

    日本歯科保存学会2018年度春季学術大会  2018.6 

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：横浜みなとみらいホール   Country：Japan  

  • Theroleofproteoglycansinthepathogenesisof druginducedgingivalovergrowth（DIGO）

    第61回春季日本歯周病学会学術大会  2018.6 

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京王プラザホテル   Country：Japan  

  • 広汎性侵襲性歯周炎患者に歯周組織再生療法を含む包括的治療を行った一症例

    福田 隆男, 中尾 雄紀, 讃井 彰一, 豊田 敬介, 田中 麗, 西村 英紀

    日本歯周病学会60周年記念京都大会  2017.12 

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    Event date： 2017.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都国際会館   Country：Japan  

  • Angiopietin-like protein2とSP7および下流ALP遺伝子発現の関連性の解析

    #桃谷 勇太郎, #設楽 沙月, @高野 愛子, @福田 隆男, #黒木 慎太郎, #設楽 沙月, #Rehab Alshargabi, @西村 英紀

    日本歯周病学会60周年記念京都大会  2017.12 

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    Event date： 2017.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都国際会館   Country：Japan  

  • ST2細胞の骨芽細胞分化におけるAngiopietin-like protein2の役割

    #設楽 沙月, @高野 愛子, @福田 隆男, #黒木 慎太郎, #桃谷 勇太郎, #Rehab Alshargabi, @西村 英紀

    日本歯周病学会60周年記念京都大会  2017.12 

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    Event date： 2017.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都国際会館   Country：Japan  

  • 間葉系幹細胞の恒常性維持におけるAngptl2の役割

    #黒木 慎太郎, @高野 愛子, @福田 隆男, #設楽 沙月, #桃谷 勇太郎, #Rehab Alshargabi, @西村 英紀

    日本歯周病学会60周年記念京都大会  2017.12 

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    Event date： 2017.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都国際会館   Country：Japan  

  • アンギオポエチン様タンパク質2は骨芽細胞分化のpositive regulatorとして機能する

    高野 愛子, 福田 隆男, 新城 尊徳, 岩下 未咲, 竹下 正章, Rehab Alshargabin, 讃井 彰一, 西村 英紀

    日本歯周病学会60周年記念京都大会  2017.12 

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    Event date： 2017.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都国際会館   Country：Japan  

  • Microarray analysis of U937 monocytic cells stimulated with amelogenin International conference

    Penn Periodontal Conference 2017  2017.6 

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    Event date： 2017.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • 歯周炎モデルマウスにおける歯槽骨吸収および破骨細胞分化へのDecitabineの高価

    田中 麗, 讃井 彰一, 福田 隆男, 西村 英紀

    第146回 日本歯科保存学会 2017年度 春季学術大会  2017.6 

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    Event date： 2017.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：リンクステーションホール青森   Country：Japan  

  • 限局性侵襲性歯周炎患者にエナメルマトリックスデリバティブによる歯周組織再生療法を行った一症例

    讃井 彰一, 四本 かれん, 豊田 敬介, 福田 隆男, 田中 麗, 山道 研介, 西村 英紀

    第60回 日本歯周病学会春季学術大会  2017.5 

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    Event date： 2017.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡国際会議場   Country：Japan  

  • プロテオーム解析と歯肉幹細胞エクソソームを応用した新規歯周病治療の分子基盤構築 Invited

    福田 隆男

    第60回 日本歯周病学会春季学術大会  2017.5 

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    Event date： 2017.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡国際会議場   Country：Japan  

  • Exosomes From TNF-alpha-treated GMSCs Induce M2 Macrophage Polarization International conference

    2017 IADR/AADR/CADR General Session & Exhibition  2017.3 

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    Event date： 2017.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：United States  

  • アメロジェニンが有する抗炎症効果の機序解明

    山道 研介, 福田 隆男, 讃井 彰一, 豊田 敬介, 田中 麗, 西村 英紀

    平成28年度日本臨床歯周病学会九州支部・日本歯周病学会九州五大学合同研修会  2016.11 

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    Event date： 2016.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長崎県歯科医師会館   Country：Japan  

  • 骨組織におけるアンジオポエチン様タンパク質2の役割の機能解析

    高野 愛子, 福田 隆男, 新城 尊徳, 岩下 未咲, 讃井 彰一, 山道 研介, 竹下 正章, 西村 英紀

    第145回 日本歯科保存学会2016年度秋季学術大会  2016.10 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：キッセイ文化ホール、松本市   Country：Japan  

  • Decitabineによる歯周炎モデルマウスにおける歯槽骨吸収抑制効果の検討

    田中 麗, 讃井 彰一, 福田 隆男, 西村 英紀

    第59回秋季日本歯周病学会学術大会  2016.10 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：朱鷺メッセ 新潟コンベンションセンター   Country：Japan  

  • Spry2 Downregulation Shifts Macrophages Toward an M2 Phenotype by Stimulation with Interferon γ and Porphyromonas gingivalis Lipopolysaccharide. International conference

    讃井 彰一, 秋山 元, 福田 隆男, 田中 麗, 豊田 敬介, 武富孝治, 西村 英紀

    2016.6 

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    Event date： 2016.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Seoul   Country：Korea, Republic of  

  • Spry2 knockdown enhances proliferation and migration but reduces differentiation of periodontal ligament cells through bFGF and EGF stimulation. International conference

    94th General Session & Exhibition of the International Association for Dental Research  2016.6 

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    Event date： 2016.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Korea, Republic of  

  • Amelogenin Modulates Macrophage Phenotype During Inflammatory Responses. International conference

    94th General Session & Exhibition of the International Association for Dental Research  2016.6 

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    Event date： 2016.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Korea, Republic of  

  • Grp78 is crucial for cell migration induced by amelogenin in a human periodontal ligament cells. International conference

    94th General Session & Exhibition of the International Association for Dental Research  2016.6 

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    Event date： 2016.6

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Korea, Republic of  

  • 骨組織におけるアンジオポエチン様タンパク質2の役割の解明

    高野 愛子, 福田 隆男, 新城 尊徳, 岩下 未咲, 讃井 彰一, 山道 研介, 竹下 正章, 西村 英紀

    第144回 日本歯科保存学会2016年度春季学術大会  2014.6 

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    Event date： 2016.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：栃木総合文化センター   Country：Japan  

  • 歯周病感染器官培養モデルを用いた抗菌薬の効果に関する研究

    竹下 正章, 原口　晃, 三浦　真由美, 濱地 貴文, 福田 隆男, 讃井 彰一, 西村 英紀

    第59回 日本歯周病学会春季学術大会  2016.5 

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    Event date： 2016.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：かごしま県民交流センター・宝山ホール   Country：Japan  

  • Molecular basis of amelogenin-induced periodontal tissue regeneration International conference

    2016.2 

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    Event date： 2016.2

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Spry2抑制によるM1マクロファージへの分化抑制メカニズムの解析

    後村 亮, 讃井 彰一, 福田 隆男, 豊田 敬介, 山道 研介, 秋山　元, 西村 英紀

    日本歯科保存学会 2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会  2015.11 

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    Event date： 2015.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：文京シビックホール   Country：Japan  

  • アメロジェニンが炎症過程におけるマクロファージの形質転換におよぼす影響

    山道 研介, 福田 隆男, 讃井 彰一, 豊田 敬介, 後村 亮, 西村 英紀

    日本歯科保存学会 2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会  2015.11 

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    Event date： 2015.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：文京シビックホール   Country：Japan  

  • アメロジェニンが有する抗炎症効果の機序解明

    山道 研介, 福田 隆男, 讃井 彰一, 豊田 敬介, 後村 亮, 秋山　元, 田中 麗, 西村 英紀

    平成27年度日本臨床歯周病学会九州支部・日本歯周病学会九州五大学合同研修会  2015.11 

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    Event date： 2015.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：アクロス福岡   Country：Japan  

  • Grp78 Is Critical For Amelogenin-induced Cell Migration In PDLSCs International conference

    The 63rd Annual Meeting of Japanese Association for Dental Research  2015.10 

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    Event date： 2015.10

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Inhibition of Sprouty2 Regulates Cell Functions in Periodontal Ligament Cells International conference

    Penn Periodontal Conference 2015  2015.7 

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    Event date： 2015.6 - 2015.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Grp78 is critical for amelogenin-induced cell migration in PDL cells International conference

    Penn Periodontal Conference 2015  2015.6 

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    Event date： 2015.6 - 2015.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Spry2がPorphyromonas gingivalis LPS刺激マクロファージの分化に及ぼす影響について

    後村 亮, 讃井 彰一, 福田 隆男, 豊田 敬介, 山道 研介, 西村 英紀

    第142回日本歯科保存学会2015年度春季学術大会  2015.6 

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    Event date： 2015.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州国際会議場   Country：Japan  

  • マクロファージにおけるアメロジェニン刺激の影響の網羅的遺伝子解析

    山道 研介, 福田 隆男, 讃井 彰一, 豊田 敬介, 後村 亮, 西村 英紀

    第142回日本歯科保存学会2015年度春季学術大会  2015.6 

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    Event date： 2015.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州国際会議場   Country：Japan  

  • 歯周病感染器官培養モデルを用いた抗菌薬の効果に関する研究

    竹下 正章, 讃井 彰一, 福田 隆男, 濱地 貴文, 西村 英紀

    第142回日本歯科保存学会2015年度春季学術大会  2015.6 

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    Event date： 2015.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州国際会議場   Country：Japan  

  • 新規に同定したアメロジェニン会合蛋白Grp78がヒト歯根膜幹細胞/前駆細胞株の機能に及ぼす役割の検討

    豊田 敬介, 福田 隆男, 讃井 彰一, 後村 亮, 山道 研介, 田中 麗, 西村 英紀

    第58回春季日本歯周病学会学術大会  2015.5 

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    Event date： 2015.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：幕張メッセ 国際会議場   Country：Japan  

  • The Effects of Spry2 in Osteoblasts and Gingival Epithelial Cells. International conference

    93rd General Session & Exhibition of the International Association for Dental Research  2015.3 

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    Event date： 2015.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Grp78 is Essential for Amelogenin-Induced Cell Migration in PDLSCs. International conference

    93rd General Session & Exhibition of the International Association for Dental Research  2015.3 

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    Event date： 2015.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Sprouty2 regulates cell proliferation and migration in periodontal ligament cells International conference

    93rd General Session & Exhibition of the International Association for Dental Research  2015.3 

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    Event date： 2015.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：United States  

  • Grp78 is critical for amelogenin-induced cell migration in a human periodontal ligament stem/progenitor cell line. International conference

    Kyudai Oral Bioscience (KOB)  2015.2 

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    Event date： 2015.2

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Sprouty2 Regulates Cell Proliferation and Migration in Periodontal Ligament Cells. International conference

    2015.2 

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    Event date： 2015.2

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Amelogenin induces cell migration via Grp78 in PDL cells International conference

    62nd Annual Meeting of Japanese Association for Dental Research  2014.12 

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    Event date： 2014.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Tyrosine 55 Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts through bFGF and EGF Stimulation but Inhibits Proliferation of Gingival Epithelial Cells: Implications for Novel Biological Approach to Periodontal Regeneration. International conference

    62nd Annual Meeting of Japanese Association for Dental Research  2014.12 

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    Event date： 2014.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • フレアーアウトを伴う歯周炎患者に歯周矯正を行った一症例

    福田 隆男, 豊田 敬介, 田中 麗, 讃井 彰一, 後村 亮, 山道 研介　, 西村 英紀

    第56回 秋季日本歯周病学会学術大会  2013.9 

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    Venue：前橋   Country：Japan  

  • Spry2を標的とした歯周組織再生療法確立を目指す基礎研究

    田中 麗, 豊田 敬介, 讃井 彰一, 福田 隆男, 後村 亮, 山道 研介　, 西村 英紀

    第57回 日本歯周病学会春季学術大会  2014.5 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長良川国際会議場、岐阜市   Country：Japan  

  • マクロファージにおけるアメロジェニン刺激が関与するpathwayの検討

    後村 亮, 豊田 敬介, 福田 隆男, 讃井 彰一, 西村 英紀

    第140回 日本歯科保存学会2014年度春季学術大会  2014.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：滋賀県立劇場びわ湖ホール、大津市   Country：Japan  

  • 新規アメロジェニン会合分子GRP78がヒト歯根膜細胞に及ぼす影響

    豊田 敬介, 後村 亮, 福田 隆男, 讃井 彰一, 西村 英紀

    第140回 日本歯科保存学会2014年度春季学術大会  2014.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：滋賀県立劇場びわ湖ホール、大津市   Country：Japan  

  • 歯周病感染器官培養モデルを用いた抗菌療法を目指す基礎研究

    竹下正章, 讃井 彰一, 福田 隆男, 西村 英紀

    第 104 回日本歯科保存学会秋季学術大会  2014.10 

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    Venue：山形テルサ、山形市   Country：Japan  

  • アメロジェニンの生物学的活性の機序解明

    豊田 敬介, 後村 亮, 福田 隆男, 讃井 彰一, 山道 研介　, 田中 麗, 西村 英紀

    平成２６年度 日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研修会  2014.11 

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：アクロス福岡、福岡市   Country：Japan  

  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果

    林 千華子, 福田 隆男, 渡邊 ゆかり, 川上 賢太郎, 豊田 真顕, 中尾 雄紀, 四本 かれん, 大和 寛明, 新城 尊徳, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2022.5  (NPO)日本歯周病学会

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  • 歯肉幹細胞由来エクソソームのM2マクロファージ誘導を介した革新的歯周治療の開発

    福田 隆男

    日本歯周病学会会誌  2022.5  (NPO)日本歯周病学会

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    Language：Japanese  

  • 幹細胞を用いたscaffold freeの骨様組織3D構造体の作製(Fabrication of stem cell-based scaffold-free bone-like 3D structures)

    Toyoda Masaaki, Kajioka Shunichi, Fujimoto Ryota, Hayashi Chikako, Kawakami Kentarou, Watanabe Yukari, Nakao Yuki, Yotumoto Karen, Sanui Terukazu, Fukuda Takao, Nakayama Koichi, Nishimura Fusanori

    日本歯周病学会会誌  2022.12  (NPO)日本歯周病学会

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  • 内皮のインスリン抵抗性は糖尿病関連歯周炎の増悪に関与する(Endothelial insulin resistance contributes to the exacerbation of diabetes-related periodontitis)

    Zeze Tatsuro, Shinjo Takanori, Sato Kohei, Imagawa Mio, Nishimura Yuki, Iwashita Misaki, Fukuda Takao, Sanui Terukazu, Nishimura Fusanori

    日本歯周病学会会誌  2022.12  (NPO)日本歯周病学会

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  • ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて

    川上 賢太郎, 渡邊 ゆかり, 林 千華子, 豊田 真顕, 新城 尊徳, 讃井 彰一, 福田 隆男, 西村 英紀

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2022.5  (NPO)日本歯科保存学会

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  • バイオ3Dプリンターを用いた歯肉幹細胞由来骨様立体構造物の作製方法の確立と骨分化能,石灰化度に関する解析

    豊田 真顕, 梶岡 俊一, 福田 隆男, 川上 賢太郎, 信太 実有, 李 金鳳, 林 千華子, 中尾 雄紀, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2023.10  (NPO)日本歯周病学会

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  • バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立体構造物作製への挑戦

    豊田 真顕, 梶岡 俊一, 福田 隆男, 渡邊 ゆかり, 林 千華子, 川上 賢太郎, 中尾 雄紀, 四本 かれん, 大和 寛明, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2022.5  (NPO)日本歯周病学会

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  • エムドゲインのプロテオミクス

    福田 隆男, 川上 賢太郎, 王 紫瑜, 肖 萌, 豊田 真顕, 林 千華子, 信太 実有, 李 金鳳, Mwannes Ahmad, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2024.4  (NPO)日本歯周病学会

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  • アメロジェニンが他家皮膚移植モデルマウスの拒絶反応に及ぼす影響

    信太 実有, 讃井 彰一, 西村 優輝, 林 千華子, 川上 賢太郎, 豊田 真顕, 新城 尊徳, 福田 隆男, 西村 英紀

    日本歯周病学会会誌  2024.4  (NPO)日本歯周病学会

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  • TNF-α/IFN-α共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する

    渡邊 ゆかり, 林 千華子, 川上 賢太郎, 豊田 真顕, 中尾 雄紀, 大和 寛明, 四本 かれん, 新城 尊徳, 岩下 未咲, 讃井 彰一, 福田 隆男, 西村 英紀

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2022.5  (NPO)日本歯科保存学会

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  • Skp1を標的としNF-κBシグナルを介した炎症を抑制するmiR-582-5pは歯周炎と肥満において抑制されている(miR-582-5p, that targets Skpl and suppresses NF-κB signaling-mediated inflammation, is down-regulated in periodontitis and obesity)

    Li Rongzhi, Sano Tomomi, Fukuda Takao, Shinjo Takanori, Iwashita Misaki, Yamashita Akiko, Sanui Terukazu, Nishimura Fusanori

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2023.5  (NPO)日本歯科保存学会

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  • ATF6βを標的としたmiR-1260bの歯周病による量吸収抑制効果(miR-1260b inhibits periodontal bone loss by targeting ATF6β)

    Hayashi Chikako, Kawakami Kentaro, Toyoda Masaaki, Watanabe Yukari, Nakao Yuki, Yotsumoto Karen, Yamato Hiroaki, Shinjo Takanori, Sanui Terukazu, Fukuda Takao, Nishimura Fusanori

    日本歯周病学会会誌  2022.12  (NPO)日本歯周病学会

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MISC

  • 歯肉幹細胞由来細胞外小胞を利用した歯周炎治療戦略 Reviewed

    福田隆男, 西村英紀

    日本歯周病学会誌　第66巻 1号 p.1-8   2024.4

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： https://doi.org/10.2329/perio.66.1

  • 歯肉幹細胞由来細胞外小胞を利用した歯周炎治療戦略

    福田 隆男, 西村 英紀

    日本歯周病学会会誌   66 ( 1 )   1 - 8   2024.3   （ ISSN:0385-0110 ）

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  • 歯肉幹細胞由来エクソソームのM2マクロファージ誘導を介した革新的歯周治療の開発 Reviewed

    福田隆男

    日本歯周病学会誌　第64 巻 4 号 p.109-115   2022.12

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： https://doi.org/10.2329/perio.64.109

  • 歯肉幹細胞由来エクソソームのM2マクロファージ誘導を介した革新的歯周治療の開発

    福田 隆男

    日本歯周病学会会誌   64 ( 4 )   109 - 115   2022.12   （ ISSN:0385-0110 ）

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    間葉系幹細胞(MCS)は組織再生に必須の多分化能のみならず、抗炎症作用や障害部位への集積能などを有する。障害を受けた組織の再生を強力にサポートするMCSの中心的役割はmiRNAを豊富に含むエクソソームが担っている。歯肉組織に存在する歯肉幹細胞(GMSC)はエクソソームの分泌量が多く、採取が容易である。GMSCへのTNF-α刺激によりエクソソームの抗炎症能が促進され、M2マクロファージが誘導される。この作用を介した歯周治療の開発について述べた。

  • 歯肉幹細胞由来エクソソームを応用した歯周炎治療の開発に向けて

    福田隆男

    和光純薬時報   2022.10

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  • 歯肉幹細胞由来エクソソームによる炎症制御 Reviewed

    福田隆男

    日本歯科保存学雑誌　第63 巻 2 号 p. 140-143   2020.4

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： https://doi.org/10.11471/shikahozon.63.140

  • 新しいがん治療を目指した我々の基礎研究

    芦塚 慈美, 福田 隆男, 桑野 信彦

    口腔組織培養学会誌　第95巻4号，348-353項   2002.10

    　More details

    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Professional Memberships

  • 国際歯科研究学会(IADR)

  • 日本歯科研究学会(JADR)

  • Japanese Association for Oral Biology

  • 日本歯科保存学会

  • 日本歯周病学会

Committee Memberships

  • Councilor   Domestic

    2019.5 - Present   

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2023

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：7

  • シンポジスト

    第65回春季日本歯周病学会学術大会  （ 京王プラザホテル ） 2022.6

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2022

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：8

  • シンポジスト International contribution

    第69回国際歯科研究学会日本部会総会・学術大会(JADR)  （ 九州大学医学部 百年講堂（福岡市） ） 2021.10

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2021

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • Screening of academic papers

    Role(s)： Peer review

    2020

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

  • シンポジスト

    第151回 日本歯科保存学会 2019年度秋季学術大会  （ 福岡国際会議場 ） 2019.11

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    Type：Competition, symposium, etc. 

  • シンポジスト

    日本歯周病学会第1回佐賀地区臨床研修会  （ 佐賀県歯科医師会館 ） 2019.2

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2019

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

  • シンポジスト

    第51回 日本歯周病学会若手研究者の集い  （ 京王プラザホテル ） 2018.5

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

  • シンポジスト

    九州大学歯学部創立50周年記念シンポジウム  （ 九州大学医学部百年講堂 ） 2017.11

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    Type：Competition, symposium, etc. 

  • シンポジスト

    第59回歯科基礎医学会学術大会  （ 松本歯科大学キャンパス ） 2017.9

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    Type：Competition, symposium, etc. 

  • シンポジスト

    第60回春季日本歯周病学会学術大会  （ 福岡国際会議場 ） 2017.5

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    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2017

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

▼display all

Research Projects

  • Spatial transcriptome analysis of GMSC-derived exoxme mediated peridontal tissue regneration

    Grant number：24K02623  2024 - 2028

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    CiNii Research

  • 歯肉幹細胞由来エクソソームによる新規歯周病治療の開発

    2024 - 2025

    AMED 橋渡し研究戦略的推進プログラム　シーズA

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • Challenge to periodontal tissue regeneration and refractory immune diseases based on amelogenin-CRP78 complex

    Grant number：23K27774  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Grant type：Scientific research funding

    CiNii Research

  • アメロジェニン・CRP78複合体を基軸とした歯周組織再生と難治性免疫疾患への挑戦

    Grant number：23H03084  2023 - 2027

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • Sprouty2 による上皮間葉転換制御を介した扁平上皮癌転移抑制機構の解明

    Grant number：20K10173  2020 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    武富 孝治, 讃井 彰一, 福田 隆男

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    近年、癌の分子標的薬の発展は目覚ましく、細胞表層の受容体に対するモノクローナル抗体や MEK 阻害剤に代表されるような細胞内の分子をターゲットとした分子標的薬も次々と開発されている。本研究では、細胞のチロシンキナーゼ型受容体の下流で細胞内シグナル伝達を制御する Sprouty2 に着目し、口腔扁平上皮癌細胞の上皮間葉転換 (EMT) における Sprouty2 の作用を解析する。口腔扁平上皮癌のリンパ行性転移機構において Sprouty2 が E-cadherin などの細胞接着分子の発現変化や、浸潤性発育にどのような影響を与えるかを in vitro の実験で調べる。

    CiNii Research

  • New therapeutic strategy for periodontal disease targeting exosomal miRNA derived from GMSCs.

    Grant number：20H03865  2020 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

    CiNii Research

  • The development of periodontal and endodontal tissue regenetation targeted amelogenin/GRP78 complex

    Grant number：20K09958  2020 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    CiNii Research

  • 炎症の収束と組織リモデリングを誘導する次世代歯周組織再生治療法の構築

    2017.4 - 2020.3

    　 More details

    Authorship：Coinvestigator(s) 

  • チロシンキナーゼ阻害分子 Sprouty による口腔癌リンパ節転移制御機構の解明

    2017.4 - 2020.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 歯肉幹細胞由来エクソソームを用いた新規歯周病治療の開発

    2017.4 - 2019.3

    　 More details

    Authorship：Principal investigator 

  • チロシンキナーゼ阻害分子 Sprouty による口腔癌リンパ節転移制御機構の解明

    Grant number：17K11692  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    武富 孝治, 讃井 彰一, 福田 隆男

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    Sproutyファミリーは EGF や TGF-βによる刺激よりも FGF により発現誘導されるが、その機能はチロシンキナーゼ型受容体下流のシグナル伝達機構の制御のみならず、上皮間葉転換と深く関わりのある TGF-βシグナル伝達機構における Smad1/5/8 のリン酸化も抑制することが示され、上皮間葉転換を負に制御する可能性を見いだすことができた。また、Raft においてMAPキナーゼ経路のみで作用する Caveolin との結合は、Spry ドメインのシステイン rich な領域が関与しており、TGF-βシグナルの抑制は Caveolin 非依存的に作用することが示唆された。

    CiNii Research

  • 炎症の収束と組織リモデリングを誘導する次世代歯周組織再生治療法の構築

    Grant number：17K11986  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 歯肉幹細胞由来エクソソームを用いた新規歯周病治療の開発

    Grant number：17K11987  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 新規アメロジェニン会合分子を標的とした歯周組織再生療法の発明

    2014.4 - 2017.3

    　 More details

    Authorship：Principal investigator 

  • FGF抑制因子Sprouty/Spred によるエナメル上皮腫増殖制御機構の解明

    2014.4 - 2016.3

    　 More details

    Authorship：Coinvestigator(s) 

  • M2マクロファージ転換技術を応用した新規歯周組織再生療法の開発

    2014.4 - 2016.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 歯髄細胞由来TNF誘導因子（DPTIF)受容体の探索研究

    2014.4 - 2016.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 新規アメロジェニン会合蛋白の分子基盤構築による歯周組織再生の創薬標的分子の同定

    Grant number：26463137  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • M2マクロファージ転換技術を応用した新規歯周組織再生療法の開発

    Grant number：70507780  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 歯髄細胞由来TNF誘導因子（DPTIF)受容体の探索研究

    Grant number：26670824  2014 - 2016

    科学研究費助成事業  挑戦的萌芽研究

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • FGF抑制因子Sprouty/Spred によるエナメル上皮腫増殖制御機構の解明

    Grant number：26462864  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • 平成26年度 学術研究振興基金助成金、FGF抑制因子Sprouty/Spred によるエナメル上皮腫増殖制御機構の解明

    2014

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    Grant type：Donation

  • 新規エナメル基質蛋白会合分子を標的とした歯周組織再生のプロテオーム創薬

    Grant number：23792480  2011 - 2013

    科学研究費助成事業  若手研究(B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • PGRP-Sによる粘膜免疫制御機構の解明

    2011

    　 More details

    Grant type：Donation

  • 新規アメロジェニン会合分子を標的とした歯周組織再生療法の発明

    Grant number：21792124  2009 - 2010

    科学研究費助成事業  若手研究(B)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 2009年度医学系研究奨励金

    2009

    　 More details

    Grant type：Donation

▼display all

Class subject

  • 歯周病学Ⅰ

    2024.10 - 2025.3   Second semester

  • 学生臨床実習

    2024.4 - 2025.3   Full year

  • 歯周病学II（模型基礎実習）

    2024.4 - 2024.9   First semester

  • 臨床予備実習

    2024.4 - 2024.9   First semester

  • 歯周病学Ⅰ

    2023.10 - 2024.3   Second semester

  • 学生臨床実習

    2023.4 - 2024.3   Full year

  • 次世代研究者挑戦的研究プログラム：リサーチプロポーザル

    2023.4 - 2024.3   Full year

  • 歯周病学II（模型基礎実習）

    2023.4 - 2023.9   First semester

  • 臨床予備実習

    2023.4 - 2023.9   First semester

  • 歯周病学Ⅰ

    2022.10 - 2023.3   Second semester

  • 学生臨床実習

    2022.4 - 2023.3   Full year

  • 次世代研究者挑戦的研究プログラム：リサーチプロポーザル

    2022.4 - 2023.3   Full year

  • 臨床予備実習

    2022.4 - 2022.9   First semester

  • 歯周病学II（模型基礎実習）

    2022.4 - 2022.9   First semester

  • 歯周病学Ⅰ

    2021.10 - 2022.3   Second semester

  • 基幹教育セミナー

    2021.6 - 2021.8   Summer quarter

  • 学生臨床実習

    2021.4 - 2022.3   Full year

  • 歯周病学II（模型基礎実習）

    2021.4 - 2021.9   First semester

  • 臨床予備実習

    2021.4 - 2021.9   First semester

  • 歯周病学Ⅰ

    2020.10 - 2021.3   Second semester

  • 学生臨床実習

    2020.4 - 2021.3   Full year

  • 【TBL】歯学総論５・歯学総論６

    2020.4 - 2020.9   First semester

  • 歯周病学II（模型基礎実習）

    2020.4 - 2020.9   First semester

  • 臨床予備実習

    2020.4 - 2020.9   First semester

  • 歯周病学Ⅰ

    2019.10 - 2020.3   Second semester

  • 臨床予備実習

    2019.4 - 2019.9   First semester

  • 歯周病学II（模型基礎実習）

    2019.4 - 2019.9   First semester

  • 歯周病学Ⅰ

    2018.10 - 2019.3   Second semester

  • 学生臨床実習

    2018.4 - 2019.3   Full year

  • 歯周病学II（模型基礎実習）

    2018.4 - 2018.9   First semester

  • 歯周病学Ⅰ

    2017.10 - 2018.3   Second semester

  • 前期, 臨床予備実習.

    2017.4 - 2017.9   First semester

  • 臨床予備見学・シミュレーション実習.

    2017.4 - 2017.9   First semester

  • 歯周病学Ⅰ

    2015.10 - 2016.3   Second semester

  • 学生臨床実習

    2015.4 - 2016.3   Full year

  • 歯周病学II（模型基礎実習）

    2015.4 - 2015.9   First semester

  • 臨床予備見学・シミュレーション実習

    2015.4 - 2015.9   First semester

  • 臨床予備実習

    2015.4 - 2015.9   First semester

  • 歯周病学 I

    2014.10 - 2015.3   Second semester

  • 学生臨床実習

    2014.4 - 2015.3   Full year

  • 歯周病学II（模型基礎実習）

    2014.4 - 2014.9   First semester

▼display all

FD Participation

  • 2023.8   Role：Participation   Title：令和５年度馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.6   Role：Participation   Title：科学研究費補助金採択率向上に向けた工夫

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.7   Role：Participation   Title：科研費申請書ー採択に近づく書き方のコツ

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role：Participation   Title：2022年度CPXの概要と昨年度からの変更点について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.6   Role：Participation   Title：電子ジャーナルをめぐる現状と今後に向けた対応について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.9   Role：Participation   Title：歯学研究院令和元年度第１回FD「科研費申請のススメ！～科学研究費補助金制度と研究計画調書作成時の注意点～」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.5   Role：Participation   Title：一斉技能試験トライアル教員FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2019.3   Role：Participation   Title：2019年度臨床実地試験トライアル説明会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.8   Role：Participation   Title：「歯学研究院の研究力分析と研究力強化に向けたScopus/Scival/Pure活用例」「BIツールを用いた研究力分析の紹介」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.5   Role：Participation   Title：臨床実習御臨床能力試験トライアルの実施に向けて.

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2018.3   Role：Participation   Title：東京医科歯科大学における国家試験対策の実践.

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2017.11   Role：Participation   Title：ARO次世代医療センターの活用方法.

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2016.2   Role：Participation   Title：H28年度課題協学科目FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2015.12   Role：Participation   Title：第二回歯学研究院FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2015.9   Role：Participation   Title：歯学研究院第一回FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2014.9   Role：Participation   Title：科研費獲得のポイント

    Organizer：[Undergraduate school/graduate school/graduate faculty]

▼display all

Other educational activity and Special note

  • 2023  Special Affairs 

  • 2023  Special Affairs 

  • 2022  Special Affairs 

  • 2022  Special Affairs 

  • 2022  Special Affairs 

  • 2022  Special Affairs 

  • 2020  Special Affairs 

  • 2020  Special Affairs 

  • 2019  Special Affairs 

  • 2017  Special Affairs 

  • 2017  Special Affairs 

  • 2017  Special Affairs 

  • 2015  Special Affairs 

  • 2014  Special Affairs 

  • 2014  Special Affairs 

▼display all

Social Activities

  • 歯周外科の基礎と勘所

    ２０２１年度医療法人宝歯会　学術セミナー  宝歯会小倉事務所  2021.9

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • 歯肉幹細胞由来エクソソームを応用した歯周病治療の開発に向けて

    第八回WAKO Web受託セミナー　～間葉系幹細胞研究の最前線～  ウェビナーにて開催  2021.3

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

  • 特別講演 II「歯周組織再生療法の変遷と展望」

    日本歯周病学会第 1 回佐賀地区臨床研修会  佐賀県歯科医師会館  2019.2

    　More details

    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

Travel Abroad

  • 2016.3 - 2017.3

    Staying countory name 1：United States   Staying institution name 1：Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Dentistry / Periodontal Dentistry

Clinician qualification

  • Preceptor

    日本歯周病学会

  • Specialist

    日本歯周病学会

Year of medical license acquisition

  • 2000

Notable Clinical Activities

  • 臨床研究認定歯科医師