Updated on 2024/10/09

Information

 

写真a

 
SANUI TERUKAZU
 
Organization
Kyushu University Hospital Periodontics Lecturer
School of Dentistry Department of Dentistry(Joint Appointment)
Graduate School of Dental Science (Joint Appointment)
Graduate School of Dental Science Department of Dental Science(Joint Appointment)
Title
Lecturer
Contact information
メールアドレス
Tel
0926426358
Profile
・研究活動 歯周炎における病態とその後に起こる歯周組織修復・再生を分子生物学レベルで解明する研究を行っている。 ・教育活動 歯学部4年生の臨床基礎実習における講義および指導、同5年生の臨床予備実習および臨床実習における指導、同6年生の臨床実習およびリサーチエクスポージャーにおける指導を行っている。 ・診療活動 九州大学病院歯周病科で、歯周病の治療を中心に、齲蝕の保存修復治療、歯髄炎・感染根管の治療を行っている。
External link

Degree

  • Doctor of Philosophy for Dentistry

Research Interests・Research Keywords

  • Research theme:Complex of amelogenin and GRP78 promotes periodontal tissue regeneration.

    Keyword:periodontitis amelogenin GRP78

    Research period: 2017.4 - 2022.3

  • Research theme:Antagonists of growth factor receptors, Sproutys, could be a therapeutic target for periodontitis.

    Keyword:periodontal disease, regenerative therapy, growth factor

    Research period: 2008.4 - 2010.3

  • Research theme:Analysis of the relationship between periodntal disease and cytoskelton of T lymphocytes.

    Keyword:periodontal disease, cytoskelton, T lymphocyte

    Research period: 2005.4 - 2008.3

Awards

  • 第17回(2017年度)日本歯周病学会学術賞

    2017.12   日本歯周病学会   細胞骨格制御分子を標的とした新規歯周治療法の開発に関する基礎的研究

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    細胞骨格制御分子を標的とした新規歯周治療法の開発に関する基礎的研究

  • 財団法人武田科学振興財団医学系研究奨励<臨床>助成金受賞

    2017.11   財団法人武田科学振興財団   炎症終焉と組織再構築を誘導する次世代歯周組織再生治療薬の発明

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    炎症終焉と組織再構築を誘導する次世代歯周組織再生治療薬の発明

  • 平成26年度学術研究振興基金助成金

    2014.4   久留米大学   FGF抑制因子Sprouty/Spred によるエナメル上皮腫増殖制御機構の解明

  • 2011年度上原記念生命科学財団研究奨励金受賞

    2011.12   上原記念生命科学財団   PGRP-Sによる粘膜免疫制御機構の解明

  • ICPF 2010 Best Paper Award, Co-researcher

    2010.6   International Cleft Palate Foundation  

  • 第64回学会賞優秀発表賞 共同研究者

    2010.6   日本口腔科学会   Sprouty2 KO マウスが口蓋裂を呈することから、その発症メカニズムと役割について、シグナル伝達機構を中心に解析した。

  • 財団法人武田科学振興財団医学系研究奨励<生活習慣病>助成金受賞

    2009.8   財団法人武田科学振興財団   塩基性線維芽細胞成長因子(bFGF)シグナルのアンタゴニストを標的とした歯周組織再生療法の開発

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Papers

  • Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells. Reviewed International journal

    Yamato H, Sanui T, Yotsumoto K, Nakao Y, Watanabe Y, Hayashi C, Aihara R, Iwashita M, Tanaka U, Taketomi T, Fukuda T, Nishimura F.

    Journal of Cellular Biochemistry   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/jcb.29903.

  • Amelogenin downregulates interferon gamma-induced major histocompatibility complex class II expression through suppression of euchromatin formation in the class II transactivator promoter IV region in macrophages. Reviewed International journal

    Yotsumoto K, Sanui T, Tanaka U, Yamato H, Alshargabi R, Shinjo T, Nakao Y, Watanabe Y, Hayashi C, Taketomi T, Fukuda T, Nishimura F

    Frontiers in Immunology   11   709 - 709   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.3389/fimmu.2020.00709

  • Sprouty2 Inhibition Resolves Inflammation in Periodontal Disease and Creates a Suitable Environment for Periodontal Tissue Regeneration. Reviewed

    Sanui T, Fukuda T, Tanaka U, Toyoda K, Yotsumoto K, Nakao Y, Yamato H, Taketomi T, Nishimura F

    Journal of Cell Biology & Immunology   1   101 - 101   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Roles of serum in innate immune responses of human leukocytes to synthetic lipopeptide Reviewed

    Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura

    International Immunopharmacology   50   61 - 68   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.intimp.2017.06.006

  • Adhesion attenuates respiratory burst induced by different modes of triggering in resting or LPS-primed neutrophils Reviewed

    Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura

    Immunobiology   222 ( 8-9 )   865 - 871   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.imbio.2017.05.001

  • Microarray analysis of the effects of amelogenin on U937 monocytic cells. Reviewed International journal

    American Journal of Molecular Biology   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Anti-CD14 Antibody-treated Neutrophils Respond to LPS Possible Involvement of CD14 Upregulated by Anti-CD14 Antibody Binding Reviewed

    Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Akira Haraguchi, Yoshitomi Aida, Fusanori Nishimura

    Immunological Investigations   46 ( 2 )   190 - 200   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/08820139.2016.1238925

  • Biological effects of Sprouty2 inhibition in periodontal ligament cells. Reviewed International journal

    Journal of Cell Signaling   1 ( 117 )   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4172/jcs.1000117

  • Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts but Inhibits Proliferation of Gingival Epithelial Cells Reviewed

    Terukazu Sanui, Urara Tanaka, Takao Fukuda, Kyousuke Toyoda, Takaharu Taketomi, Ryo Atomura, Kensuke Yamamichi, Fusanori Nishimura

    Journal of Cellular Biochemistry   116 ( 4 )   628 - 639   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcb.25014

  • Spry2 is a novel therapeutic target for periodontal tissue regeneration through fibroblast growth factor receptor signaling and epidermal growth factor signaling Invited Reviewed International journal

    Receptors & Clinical Investigation   e597 - e597   2015.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.14800/rci.597

  • Analysis of Streptococcus mutans biofilm proteins recognized by salivary immunoglobulin A Reviewed

    Terukazu Sanui, R. L. Gregory

    Molecular Oral Microbiology   24 ( 5 )   361 - 368   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1399-302X.2009.00523.x

  • DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1 Reviewed

    Terukazu Sanui, Ayumi Inayoshi, Mayuko Noda, Eiko Iwata, Jens V. Stein, Takehiko Sasazuki, Yoshinori Fukui

    Blood   102 ( 8 )   2948 - 2950   2003.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2003-01-0173

  • DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, in T cells Reviewed

    19 ( 1 )   119 - 129   2003.7

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    DOCK2 is a mammalian homolog of Caenorhabditis elegans CED-5 and Drosophila melanogaster Myoblast City which are known to regulate actin cytoskeleton. DOCK2 is critical for lymphocyte migration, yet the role of DOCK2 in TCR signaling remains unclear. We show here that DOCK2 is essential for TCR-mediated Rac activation and immunological synapse formation. In DOCK2-deficient T cells, antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, to the APC interface was severely impaired, resulting in a significant reduction of antigen-specific T cell proliferation. In addition, we found that the efficacy of both positive and negative selection was reduced in DOCK2-deficient mice. These results suggest that DOCK2 regulates T cell responsiveness through remodeling of actin cytoskeleton via Rac activation.

    DOI: 10.1016/S1074-7613(03)00169-9

  • Preoperative endovascular arterial embolization to avoid maxillary artery injury in maxillary gingival cancer surgery

    Taketomi T., Sanui T., Fukuda T., Takeshita G., Nojiri J.

    Radiology Case Reports   19 ( 8 )   3561 - 3568   2024.8   ISSN:1930-0433

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    For maxillary gingival carcinomas, especially those in the molar region, surgical resection is often performed beyond the maxillary tuberosity. Bleeding from the posterior superior alveolar or maxillary artery into the pterygoid process is difficult to stop during partial maxillary resection. Advances in catheterization and materials have enabled the embolization of various vessels. In this report, we describe two cases of maxillary gingival cancer in which preoperative endovascular arterial embolization prevented bleeding due to unexpected vascular injury, allowing for a safe surgery with minimal blood loss. This technique effectively avoids emergency hemostasis for unexpected bleeding when resecting gingival cancers in the maxillary molar region.

    DOI: 10.1016/j.radcr.2024.05.052

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  • An 84-Year-Old Man with a History of Myeloma and Biphosphonate-Related Osteonecrosis of the Jaw Treated with Preoperative Vascular Embolization Before Partial Maxillectomy

    Taketomi, T; Fukuda, T; Nojiri, J; Sanui, T

    AMERICAN JOURNAL OF CASE REPORTS   25   e943807   2024.7   eISSN:1941-5923

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    Language:English   Publisher:American Journal of Case Reports  

    Objective: Rare disease Background: Bisphosphonates and anti-receptor activator of nuclear factor kappa B antibodies are used to treat bone diseases associated with increased osteoclast activity, including myeloma. However, they can cause osteonecrosis of the jaw, known as medication-related osteonecrosis of the jaw. This report presents a case of a patient with a history of myeloma who required posterior maxilla resection for bisphosphonate-related osteonecrosis of the jaw, in which preoperative embolization prevented unexpected bleeding related to vascular injury and allowed for a safe procedure with minimal bleeding. Case Report: An 84-year-old man presented to our department with a 3-year history of purulent drainage and bone exposure in the right maxilla. Based on the clinical findings at the initial visit, the clinical diagnosis was bisphosphonate-related osteonecrosis of the jaw, and the patient underwent a partial right maxillary osteotomy. This surgery was associated with a risk of unexpected bleeding from a branch of the maxillary artery during the posterior maxilla resection. A catheter-based embolization of the maxillary artery was performed the day before performing a partial maxillectomy to avoid unexpected bleeding risk. Thus, no abnormal bleeding occurred during partial maxillectomy, and no postoperative complications occurred for 3 years. Conclusions: In the surgical treatment of medication-related osteonecrosis of the jaw, preoperative vascular embolization of the peripheral maxillary artery beyond the middle meningeal artery bifurcation is a valuable technique for safe maxillectomy involving the posterior maxilla.

    DOI: 10.12659/AJCR.943807

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  • Scaffold-free bone-like 3D structure established through osteogenic differentiation from human gingiva-derived stem cells. Reviewed International journal

    Toyoda M, Fukuda T, Fujimoto R, Kawakami K, Hayashi C, Nakao Y, Watanabe Y, Aoki T, Shida M, Sanui T, Taguchi M, Yamamichi K, Okabe A, Okada T, Oka K, Nakayama K, Nishimura F, Kajioka S.

    Biomed Res Int   15 ( 38 )   101656 - 101656   2024.2   ISSN:2405-5808

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    DOI: 10.1016/j.bbrep.2024.101656

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  • Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation

    Kawakami Kentaro, Fukuda Takao, Toyoda Masaaki, Nakao Yuki, Hayashi Chikako, Watanabe Yukari, Aoki Tsukasa, Shinjo Takanori, Iwashita Misaki, Yamashita Akiko, Shida Miyu, Sanui Terukazu, Uchiumi Takeshi, Nishimura Fusanori

    BioMed Research International   2024   8864513   2024.1   ISSN:23146133 eISSN:23146141

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    Aim. The present study evaluated the therapeutic effects of luteolin in alleviating pulpitis of dental pulp- (DP-) derived microvesicles (MVs) via the inhibition of protein kinase R- (PKR-) mediated inflammation. Methodology. Proteomic analysis of immortalized human dental pulp (DP-1) cell-derived MVs was performed to identify PKR-associated molecules. The effect of luteolin on PKR phosphorylation in DP-1 cells and the expression of tumor necrosis factor-α (TNF-α) in THP-1 macrophage-like cells were validated. The effect of luteolin on cell proliferation was compared with that of chemical PKR inhibitors (C16 and 2-AP) and the unique commercially available sedative guaiacol-parachlorophenol. In the dog experimental pulpitis model, the pulps were treated with (1) saline, (2) guaiacol-parachlorophenol, and (3) luteolin. Sixteen teeth from four dogs were extracted, and the pulp tissues were analyzed using hematoxylin and eosin staining. Immunohistochemical staining was performed to analyze the expression of phosphorylated PKR (pPKR), myeloperoxidase (MPO), and CD68. Experimental endodontic-periodontal complex lesions were established in mouse molar through a silk ligature and simultaneous MV injection. MVs were prepared from DP-1 cells with or without pretreatment with 2-AP or luteolin. A three-dimensional microcomputed tomography analysis was performed on day 7 (n=6). Periodontal bone resorption volumes were calculated for each group (nonligated–ligated), and the ratio of bone volume to tissue volume was measured. Results. Proteomic analysis identified an endogenous PKR activator, and a protein activator of interferon-induced PKR, also known as PACT, was included in MVs. Luteolin inhibited the expressions of pPKR in DP-1 cells and TNF-α in THP-1 cells with the lowest suppression of cell proliferation. In the dog model of experimental pulpitis, luteolin treatment suppressed the expression of pPKR-, MPO-, and CD68-positive cells in pulp tissues, whereas guaiacol-parachlorophenol treatment caused coagulative necrosis and disruption. In a mouse model of endodontic-periodontal complex lesions, luteolin treatment significantly decreased MV-induced alveolar bone resorption. Conclusion. Luteolin is an effective and safe compound that inhibits PKR activation in DP-derived MVs, enabling pulp preservation.

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  • Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation. Reviewed International journal

    Kawakami K, Fukuda T, Toyoda M, Nakao Y, Hayashi C, Watanabe Y, Aoki T, Shinjo T, Iwashita M, Yamashita A, Shida M, Sanui T, Uchiumi T, Nishimura F.

    Biomed Res Int   2024   8864513 - 8864513   2024.1   ISSN:2314-6133 eISSN:2314-6141

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    DOI: 10.1155/2024/8864513

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  • Luteolin, chemical feature and potential use for oral disease

    Fukuda T., Kawakami K., Toyoda M., Hayashi C., Sanui T., Uchiumi T.

    Current Oral Health Reports   2024

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    Publisher:Current Oral Health Reports  

    Purpose of Review: Luteolin, a natural polyphenolic flavone, is a bioactive compound with high thermal stability. Owing to its prominent antioxidant activity, luteolin has been reported to exert therapeutic effects on inflammation-associated diseases. This review discusses the therapeutic potential of luteolin for treating dental diseases. Recent Findings: Luteolin has multifaceted pharmacological activities, including anti-inflammatory, neuroprotective, anticancer, and cardioprotective effects. Furthermore, the antibacterial effects of luteolin are accompanied by an anti-biofilm effect. More recently, luteolin has been identified as an inhibitor of protein kinase R (PKR), which plays an essential role in inflammasome activation. In this regard, we demonstrated the potential of luteolin as a pulp sedation compound for pulpitis that acts by suppressing PKR-mediated inflammation in dental pulp cells. Summary: Although conventional dental treatments for dental caries or periodontitis largely depend on cause-related therapy, disruption of biofilms and regulation of inflammation are prerequisites for a favorable prognosis. Together with its superior anti-inflammatory and antibacterial effects, the biocompatible features of luteolin make it a promising candidate for treating dental diseases with fewer side effects.

    DOI: 10.1007/s40496-024-00389-w

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  • Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development

    Imagawa Mio, Shinjo Takanori, Sato Kohei, Kawakami Kentaro, Zeze Tatsuro, Nishimura Yuki, Toyoda Masaaki, Chen Shuang, Ryo Naoaki, Ahmed Al-kafee, Iwashita Misaki, Yamashita Akiko, Fukuda Takao, Sanui Terukazu, Nishimura Fusanori

    Frontiers in Physiology   14   2023.12   eISSN:1664042X

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    Drug-induced gingival overgrowth (DIGO), induced by certain immunosuppressive drugs, antihypertensive agents, and antiepileptic drugs, may contribute to the formation of deeper periodontal pockets and intractableness in periodontitis. To date, multiple factors such as enhanced matrix production, inflammation, and reduced matrix degradation might be involved in the pathogenesis of DIGO. We have previously reported that SPOCK-1, a heparan sulfate proteoglycan, could affect gingival thickening by promoting epithelial-to-mesenchymal transition (EMT) in gingival keratinocytes. However, few studies have investigated whether a combination of these factors enhances the DIGO phenotype in animal models. Therefore, we investigated whether SPOCK-1, periodontal inflammation, and cyclosporin-A (CsA) could cooperatively promote gingival overgrowth. We first confirmed that Spock-1 overexpressing (Spock1-Tg) mice showed significantly thicker gingiva and greater alveolar bone loss than WT mice in response to ligature-induced experimental periodontitis. DIGO was induced by the combination of CsA administration and experimental periodontitis was significantly enhanced in Spock1-Tg mice compared to that in WT mice. Ligature-induced alveolar bone loss in CsA-treated Spock1-Tg mice was also significantly greater than that in CsA-treated WT mice, while being accompanied by an increase in Rankl and Col1a1 levels and a reduction in matrix metalloprotease expression. Lastly, SPOCK-1 promoted RANKL-induced osteoclast differentiation in both human peripheral blood mononuclear cells and murine macrophages, while peritoneal macrophages from Spock1-Tg mice showed less TNFα and IL-1β secretion than WT mice in response to Escherichia coli lipopolysaccharide. These results suggest that EMT, periodontal inflammation, and subsequent enhanced collagen production and reduced proteinase production contribute to CsA-induced DIGO pathogenesis.

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  • Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development. Reviewed International journal

    Imagawa M, Shinjo T, Sato K, Kawakami K, Zeze T, Nishimura Y, Toyoda M, Chen S, Ryo N, Ahmed AK, Iwashita M, Yamashita A, Fukuda T, Sanui T, Nishimura F.

    Front Physiol   13 ( 14 )   1298813 - 1298813   2023.12   ISSN:1664-042X eISSN:1664-042X

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    DOI: 10.3389/fphys.2023.1298813

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  • A Case of a Dentigerous Cyst in the Maxillary Sinus Treated Preoperatively with Vascular Embolization to Avoid Intraoperative Abnormal Bleeding. Reviewed International journal

    Taketomi T, Fukuda T, Takeshita G, Sanui T.

    Cureus   15 ( 12 )   e50228 - e50228   2023.12   ISSN:2168-8184 eISSN:2168-8184

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    DOI: 10.7759/cureus.50228

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  • Endothelial Insulin Resistance Exacerbates Experimental Periodontitis. Reviewed International journal

    Zeze T, Shinjo T, Sato K, Nishimura Y, Imagawa M, Chen S, Ahmed A-K, Iwashita M, Yamashita A, Fukuda T, Sanui T, Park K, King GL, Nishimura F.

    J Dent Res   102 ( 10 )   1152 - 1161   2023.9   ISSN:0022-0345 eISSN:1544-0591

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    DOI: 10.1177/00220345231181539

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  • miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation. Reviewed International journal

    Li, RZ; Sano, T; Mizokami, A; Fukuda, T; Shinjo, T; Iwashita, M; Yamashita, A; Sanui, T; Nakatsu, Y; Sotomaru, Y; Asano, T; Kanematsu, T; Nishimura, F

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   15 ( 734 )   109501 - 109501   2023.1   ISSN:0003-9861 eISSN:1096-0384

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Archives of Biochemistry and Biophysics  

    A well-tuned inflammatory response is crucial for an effective immune process. Nuclear factor-kappa B (NF-κB) is a key mediator of inflammatory and innate immunity responses, and its dysregulation is closely associated with immune-related diseases. MicroRNAs (miRNAs) are important inflammation modulators. However, miRNA-regulated mechanisms that implicate NF-κB activity are not fully understood. This study aimed to identify a potential miRNA that could modulate the dysregulated NF-κB signaling during inflammation. We identified miR-582-5p that was significantly downregulated in inflamed murine adipose tissues and RAW264.7 cells. S-phase kinase-associated protein 1 (SKP1), a core component of an E3 ubiquitin ligase that regulates the NF-κB pathway, was proposed as a biological target of miR-582-5p by using TargetScan. The binding of miR-582-5p to a 3′-untranslated region site on Skp1 was confirmed using a dual-luciferase reporter assay; in addition, transfection with a miR-582-5p mimic suppressed SKP1 expression in RAW264.7 cells. Importantly, exogenous miR-582-5p attenuated the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 through suppressing the degradation of the NF-κB inhibitor alpha, followed by the nuclear translocation of NF-κB. Therefore, exogenously applied miR-582-5p can attenuate the NF-κB signaling pathway via targeting Skp1; this provides a prospective therapeutic strategy for treating inflammatory and immune diseases.

    DOI: 10.1016/j.abb.2022.109501

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  • miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress

    Hayashi Chikako, Fukuda Takao, Kawakami Kentaro, Toyoda Masaaki, Nakao Yuki, Watanabe Yukari, Shinjo Takanori, Sano Tomomi, Iwashita Misaki, Yotsumoto Karen, Shida Miyu, Taketomi Takaharu, Sanui Terukazu, Uchiumi Takeshi, Kanematsu Takashi, Nishimura Fusanori

    Frontiers in Cell and Developmental Biology   10   1061216   2022.11   ISSN:2296-634X eISSN:2296634X

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    The expression profiles of exosomal microRNAs (miRNAs) are regulated by the microenvironment, and appropriate priming with mesenchymal stem cells (MSCs) is one of the strategies to enhance the paracrine potency of MSCs. Our previous work demonstrated that exosomes from tumor necrosis factor (TNF)-α-primed human gingiva-derived MSCs (GMSCs) could be a therapeutic tool against periodontitis, and that TNFα-inducible exosomal miR-1260b is essential for the inhibition of alveolar bone loss. However, the precise molecular mechanism underlying miR-1260b-mediated inhibition of osteoclastogenesis is not yet fully understood. Here, we found that the activating transcription factor (ATF)-6β, a novel miR-1260b-targeting gene, is critical for the regulation of osteoclastogenesis under endoplasmic reticulum (ER) stress. An experimental periodontal mouse model demonstrated that induction of ER stress was accompanied by enhanced ATF6β expression, and local administration of miR-1260b and ATF6β siRNA using polyethylenimine nanoparticles (PEI-NPs) significantly suppressed the periodontal bone resorption. In periodontal ligament (PDL) cells, the ER stress inducer, tunicamycin, enhanced the expression of the receptor activator of NF-κB ligand (RANKL), while miR-1260b-mediated downregulation of ATF6β caused RANKL inhibition. Furthermore, the secretome from miR-1260b/ATF6β-axis-activated PDL cells inhibited osteoclastogenesis in human CD14^+ peripheral blood-derived monocytes. These results indicate that the miR-1260b/ATF6β axis mediates the regulation of ER stress, which may be used as a novel therapeutic strategy to treat periodontal disease.

    DOI: 10.3389/fcell.2022.1061216

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  • miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress

    Hayashi, C; Fukuda, T; Kawakami, K; Toyoda, M; Nakao, Y; Watanabe, Y; Shinjo, T; Sano, T; Iwashita, M; Yotsumoto, K; Shida, M; Taketomi, T; Sanui, T; Uchiumi, T; Kanematsu, T; Nishimura, F

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   10   2022.11   ISSN:2296-634X

  • miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress. Reviewed International journal

    30 ( 10 )   1061216. - 1061216.   2022.11

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    DOI: doi: 10.3389/fcell.2022.1061216. eCollection 2022.

  • XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis. Reviewed International journal

    59 ( 10 )   1275 - 1286   2022.10

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    DOI: doi: 10.1007/s00592-022-01930-y.

  • XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis

    Nishimura, Y; Iwashita, M; Hayashi, M; Shinjo, T; Watanabe, Y; Zeze, T; Yamashita, A; Fukuda, T; Sanui, T; Sano, T; Asano, T; Nishimura, F

    ACTA DIABETOLOGICA   59 ( 10 )   1275 - 1286   2022.10   ISSN:0940-5429 eISSN:1432-5233

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    Language:English   Publisher:Acta Diabetologica  

    Aims: Pancreatic β-cell apoptosis may be involved in the onset and progression of type 2 diabetes mellitus, although its mechanism remains unclear. We previously demonstrated that macrophage-derived interferon (IFN) β induced X-linked inhibitor of apoptosis–associated factor 1 (XAF1) expression in β-cells and accelerated β-cell apoptosis in vitro. Here, we explored the effects of XAF1 on β-cell function and progression of diabetes in vivo. Methods: Pancreatic β-cell-selective XAF1 overexpressing (Xaf1 Tg) mice were generated. Xaf1 Tg mice and their wild-type (WT) littermates were fed either a normal diet or a 40% or 60% high-fat diet (HFD). The effects of β-cell XAF1 on β-cell apoptosis and exacerbation of diabetes were investigated. Results: Palmitic acid induced IFNβ expression in macrophages, and HFD intake promoted macrophage infiltration in pancreatic islets, both of which cooperatively upregulated XAF1 expression in mouse islets. Furthermore, HFD-fed Xaf1 Tg mice demonstrated increased β-cell apoptosis, lowered insulin expression, and impaired glucose tolerance compared with WT mice fed the same diet. These effects were more pronounced in the 60%HFD group than in the 40%HFD group. Conclusions: Pancreatic β-cell XAF1 expression was enhanced via HFD-induced, macrophage-derived IFNβ, which promoted β-cell apoptosis and led to a reduction in insulin secretion and progression of diabetes. To our knowledge, this is the first report to demonstrate an association between pancreatic β-cell XAF1 overexpression and exacerbation of diabetes, thus providing insight into the mechanism of β-cell mass reduction in diabetes.

    DOI: 10.1007/s00592-022-01930-y

    Web of Science

    Scopus

    PubMed

  • Basal cell adenoma of the minor salivary glands in the buccal mucosa: A case report and literature review: Basal cell adenoma of the minor salivary glands

    Taketomi T., Nakamura K., Sanui T., Fukuda T., Tominaga Y., Takase Y., Kusukawa J.

    Oral and Maxillofacial Surgery Cases   8 ( 3 )   2022.9

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    Publisher:Oral and Maxillofacial Surgery Cases  

    Basal cell adenoma (BCA) is a relatively rare benign tumor of the salivary glands. However, BCA rarely occurs in the minor salivary glands. Herein, we report a rare case of BCA that originated in the left buccal mucosa of a 47-year-old female. Magnetic resonance imaging revealed a mass with a diameter of 1.5 cm and a well-defined periphery in a high-signal area on a T2-weighted image. The mass was located between the buccal and masseter muscles on the left side of the face. A biopsy was performed, and the results indicated a pathological diagnosis of BCA. Thereafter, excision of the mass was performed under local anesthesia. Histopathological examination showed that the tumor was covered with a fibrous capsule and filled with basal cell-like cells that proliferated in a solid, tubular, and trabecular pattern, with no cellular atypia or infiltrative growth. Immunohistochemistry analysis revealed that the tumor cells inside the luminal-tubular structure showed positive immunoreactivity for CK1/3, whereas those outside expressed αSMA and vimentin. However, most of the tumor cells were p63-positive. The Ki-67 labeling index of the tumor was 3%. In addition to this report, we present a review of cases of salivary gland tumors reported from 1991 to date. The review of the 20 cases (including the present case) indicated that the most common sites of occurrence were the upper lip and palate (7 [35%] cases), buccal mucosa (4 [20%] cases), and alveolar region (2 [10%] cases). The most common histopathological type was the solid type (12 cases).

    DOI: 10.1016/j.omsc.2022.100276

    Scopus

  • Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression

    Watanabe Yukari, Fukuda Takao, Hayashi Chikako, Nakao Yuki, Toyoda Masaaki, Kawakami Kentaro, Shinjo Takanori, Iwashita Misaki, Yamato Hiroaki, Yotsumoto Karen, Taketomi Takaharu, Uchiumi Takeshi, Sanui Terukazu, Nishimura Fusanori

    Scientific Reports   12 ( 1 )   13344   2022.8   ISSN:2045-2322 eISSN:20452322

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    Language:English  

    Immunoregulatory properties of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique immunoregulatory capacity and secrete large amounts of EVs. Recent findings suggest that priming MSCs with inflammatory stimuli is an effective strategy for cell-free therapy. However, the precise mechanism by which the contents of EVs are customized has not been fully elucidated. Here, we show that EVs derived from GMSCs primed with a combination of two pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interferon-α (IFN-α), synergistically promote anti-inflammatory M2 macrophage polarization by increasing the expression of cluster of differentiation 73 (CD73) and CD5 molecule-like (CD5L). Expression of CD73 by TNF-α/IFN-α stimulation was transcriptionally upregulated by the activation of mammalian target of rapamycin signaling and nuclear translocation of hypoxia-inducible factor 1α in GMSCs. TNF-α/IFN-α treatment also significantly increased the expression of CD5L mRNA via the transcription factor DNA-binding protein inhibitor ID3 and liver X receptor. Interestingly, exosomal CD5L is a prerequisite for the synergistic effect of EVs-mediated M2 macrophage polarization. These results indicate that combined pre-licensing with TNF-α and IFN-α in GMSCs is ideal for enhancing the anti-inflammatory function of EVs, which contributes to the establishment of a therapeutic tool.

    DOI: 10.1038/s41598-022-17692-0

    Web of Science

    Scopus

    PubMed

    CiNii Research

  • Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression. Reviewed International journal

    12 ( 1 )   13344. - 13344.   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41598-022-17692-0.

  • Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain. Reviewed International journal

    Hayashi M, Iwashita M, Nishimura Y, Shinjo T, Sano T, Yamashita A, Fukuda T, Sanui T, Asano T, Nishimura F.

    BMJ Open Diabetes Res Care   9 ( 1 )   e001871. - e001871.   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1136/bmjdrc-2020-001871.

  • Exosomes from TNF-α-treated human gingiva-drived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Reviewed International journal

    122   306 - 324   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.actbio.2020.12.046.

  • SPOCK1 induces adipose tissue maturation: New insights into the function of SPOCK1 in metabolism. Reviewed International journal

    Alshargabi R, Shinjo T, Iwashita M, Yamashita A, Sano T, Nishimura Y, Hayashi M, Zeze T, Fukuda T, Sanui T, Nishimura F.

    Biochemical and Biophysical Research Communications   533 ( 4 )   1076 - 1082   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.bbrc.2020.09.129.

  • SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth. Reviewed International journal

    Alshargabi R, Sano T, Yamashita A, Takano A, Sanada T, Iwashita M, Shinjo T, Fukuda T, Sanui T, Kishida S, Nishimura F.

    Scientific Reports   10 ( 1 )   9785 - 9785   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1038/s41598-020-66660-z.

  • Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure. Reviewed International journal

    Sano T, Sanada T, Sotomaru Y, Shinjo T, Iwashita M, Yamashita A, Fukuda T, Sanui T, Asano T, Kanematsu T, Nishimura F

    Nutrition & Metabolism   4 ( 16 )   43 - 43   2019.7

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  • Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways. Reviewed International journal

    Taketomi T, Onimura T, Yoshiga D, Muratsu D, Sanui T, Fukuda T, Kusukawa J, Nakamura S

    Cell Biology International   42 ( 9 )   1106 - 1114   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbin.10876.

  • Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway Reviewed

    Kensuke Yamamichi, Takao Fukuda, Terukazu Sanui, Kyousuke Toyoda, Urara Tanaka, Yuki Nakao, Karen Yotsumoto, Hiroaki Yamato, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura

    Archives of Oral Biology   83   241 - 251   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.archoralbio.2017.08.005

  • Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation Reviewed

    Aiko Takano, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Etsuko Matsuzaki, Kensuke Yamamichi, Masaaki Takeshita, Terukazu Sanui, Fusanori Nishimura

    Metabolism: Clinical and Experimental   69   157 - 170   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.metabol.2017.01.006

  • Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance Reviewed

    Tomomi Sano, S. Nagayasu, S. Suzuki, Misaki Iwashita, Akiko Yamashita, T. Shinjo, Terukazu Sanui, A. Kushiyama, T. Kanematsu, T. Asano, Fusanori Nishimura

    Nutrition, Metabolism and Cardiovascular Diseases   27 ( 3 )   249 - 259   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.numecd.2016.11.008

  • The influence of periodontal burden on metabolic control of diabetes - Myth or reality? From a nutritional perspective - Invited Reviewed International journal

    Fusanori Nishimura, Tomomi Sano, Terukazu Sanui,

    Current Oral Health Reports   4   59 - 63   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi:10.1007/s.40496-017-0136-0

  • Innate immune-stimulatory activity of Porphyromonas gingivalis fimbriae is eliminated by phase separation using Triton X-114 Reviewed

    Kohji Nozoe, Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Akira Haraguchi, Yoshitomi Aida, Fusanori Nishimura

    Journal of Immunological Methods   441   31 - 38   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jim.2016.11.012

  • Antibiotic effects against periodontal bacteria in organ cultured tissue Reviewed

    Masaaki Takeshita, Akira Haraguchi, Mayumi Miura, Takafumi Hamachi, Takao Fukuda, Terukazu Sanui, Aiko Takano, Fusanori Nishimura

    Clinical and Experimental Dental Research   3 ( 1 )   5 - 12   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cre2.48

  • Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways Reviewed

    Takaharu Taketomi, Tomohiro Onimura, Daigo Yoshiga, Daichi Muratsu, Terukazu Sanui, Takao Fukuda, Jingo Kusukawa, Seiji Nakamura

    Cell Biology International   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbin.10876

  • IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes Reviewed

    477 ( 2 )   241 - 246   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Interleukin-17A (IL-17A) is known to induce inflammatory responses and to be involved in the pathogenesis of not only autoimmune diseases, but also several metabolic and infectious diseases. In this study, IL-17A is shown to induce IL-6 expression in 3T3-L1 mature adipocytes. Interestingly, we found that IL-17A synergistically amplified TNFα-induced secretion of IL-6 and upregulation of IL-17RA expression in 3T3-L1 adipocytes. Its synergistic effects on IL-6 production were inhibited by pre-treatment with inhibitors of IκBα and JNK. Furthermore, IL-17A cooperatively enhanced LPS-mediated IL-6 production in 3T3-L1 adipocytes co-cultured with RAW264.7 macrophages. In addition, IL-17A also enhanced CCL20 production in 3T3-L1 adipocytes stimulated with TNFα or co-cultured with LPS-stimulated RAW macrophages. In high-fat diet-fed mouse epididymal adipose tissues, IL-17RA and RORγt mRNA levels were significantly increased and the serum level of CCL20 was also upregulated. Taken together, these data show that, in adipose tissues, IL-17A contributes to exacerbating insulin resistance-enhancing IL-6 production and promotes the infiltration of Th17 cells in cooperation with TNFα; these findings represent a novel hypothesis for the association between IL-17A-producing cells and type 2 diabetes.

    DOI: 10.1016/j.bbrc.2016.06.049

  • Mechanisms of the Macrolide-Induced Inhibition of Superoxide Generation by Neutrophils Reviewed

    Kohji Nozoe, Yoshitomi Aida, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura

    Inflammation   39 ( 3 )   1039 - 1048   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10753-016-0333-3

  • Disaggregation of lipopolysaccharide by albumin, hemoglobin or high-density lipoprotein, forming complexes that prime neutrophils for enhanced release of superoxide Reviewed

    Toshiya Komatsu, Yoshitomi Aida, Takao Fukuda, Terukazu Sanui, Shunji Hiratsuka, Michael J. Pabst, Fusanori Nishimura

    Pathogens and Disease   74 ( 3 )   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/femspd/ftw003

  • Inhibition of Sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide. Reviewed International journal

    後村 亮, 讃井 彰一, 福田 隆男, 田中 麗, 豊田 敬介, 山道 研介, 武富 孝治, 西村 英紀

    26 ( 4 )   98 - 110   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/iid3.99

  • Grp78 Is Critical for Amelogenin-Induced Cell Migration in a Multipotent Clonal Human Periodontal Ligament Cell Line Reviewed

    Kyousuke Toyoda, Takao Fukuda, Terukazu Sanui, Urara Tanaka, Kensuke Yamamichi, Ryo Atomura, Hidefumi Maeda, Atsushi Tomokiyo, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura

    Journal of Cellular Physiology   231 ( 2 )   414 - 427   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.25087

  • Sprouty2 inhibition promotes proliferation and migration of periodontal ligament cells Reviewed

    Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyousuke Toyoda, T. Taketomi, R. Atomura, K. Yamamichi, Hidefumi Maeda, Fusanori Nishimura

    Oral Diseases   21 ( 8 )   977 - 986   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/odi.12369

  • Identification of Novel Amelogenin-Binding Proteins by Proteomics Analysis Reviewed

    Takao Fukuda, Terukazu Sanui, Kyousuke Toyoda, Urara Tanaka, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura

    PLoS One   8 ( 10 )   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0078129

  • Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling Reviewed

    Kaori Matsumura, Takaharu Taketomi, Keigo Yoshizaki, Shinsaku Arai, Terukazu Sanui, Daigo Yoshiga, Akihiko Yoshimura, Seiji Nakamura

    Biochemical and Biophysical Research Communications   404 ( 4 )   1076 - 1082   2011.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2010.12.116

  • DOCK2 is required in T cell precursors for development of Vα14 NK T cells Reviewed

    176 ( 8 )   4640 - 4645   2006.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    Mouse CD1d-restricted Vα14 NKT cells are a unique subset of lymphocytes, which play important roles in immune regulation, tumor surveillance and host defense against pathogens. DOCK2, a mammalian homolog of Caenorhabditis elegans CED-5 and Drosophila melanogaster myoblast city, is critical for lymphocyte migration and regulates T cell responsiveness through immunological synapse formation, yet its role in Vα14 NKT cells remains unknown. We found that DOCK2 deficiency causes marked reduction of Vα14 NKT cells in the thymus, liver, and spleen. When α-galactesylceramide (α-GalCer), a ligand for Vα14 NKT cells, was administrated, cytokine production was scarcely detected in DOCK2-deficient mice, suggesting that DOCK2 deficiency primarily affects generation of Vα14 NKT cells. Supporting this idea, staining with CD1d/α-GalCer tetramers revealed that CD44 -NK1.1- Vα14 NKT cell precursors are severely reduced in the thymuses of DOCK2-deficient mice. In addition, studies using bone marrow chimeras indicated that development of Vα14 NKT cells requires DOCK2 expression in T cell precursors, but not in APCs. These results indicate that DOCK2 is required for positive selection of Vα14 NKT cells in a cell-autonomous manner, thereby suggesting that avidity-based selection also governs development of this unique subset of lymphocytes in the thymus.

  • Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection Reviewed

    Hongsi Jiang, Fan Pan, Laurie M. Erickson, Mei Shiang Jang, Terukazu Sanui, Yuya Kunisaki, Takehiko Sasazuki, Masakazu Kobayashi, Yoshinori Fukui

    Journal of Experimental Medicine   202 ( 8 )   1121 - 1130   2005.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20050911

  • Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor Reviewed

    Yuya Kunisaki, Sadahiko Masuko, Mayuko Noda, Ayumi Inayoshi, Terukazu Sanui, Mine Harada, Takehiko Sasazuki, Yoshinori Fukui

    Blood   103 ( 9 )   3362 - 3364   2004.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2003-09-3245

  • Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide Reviewed

    T. Oono, Yoshinori Fukui, S. Masuko, O. Hashimoto, T. Ueno, Terukazu Sanui, A. Inayoshi, Mami Noda, M. Sata, T. Sasazuki

    Journal of Clinical Investigation   108 ( 11 )   1589 - 1596   2001.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/JCI200113256

  • Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration Reviewed

    Yoshinori Fukui, Osamu Hashimoto, Terukazu Sanui, Takamasa Oono, Hironori Koga, Masaaki Abe, Ayumi Inayoshi, Mayuko Noda, Masahiro Oike, Toshikazu Shirai, Takehiko Sasazuki

    Nature   412 ( 6849 )   826 - 831   2001.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/35090591

  • Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its acid residue at a T cell receptor contact Reviewed

    Yoshinori Fukui, Takamasa Oono, Jean Pierre Cabaniols, Kazuki Nakao, Katsuiku Hirokawa, Ayumi Inayoshi, Terukazu Sanui, Jean Kanellopoulos, Eiko Iwata, Mayuko Noda, Motoya Katsuki, Philippe Kourilsky, Takehiko Sasazuki

    Proceedings of the National Academy of Sciences of the United States of America   97 ( 25 )   13760 - 13765   2000.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.250470797

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Books

  • ザ・ペリオドントロジー第4版 第4章 歯周病の検査、診断と治療 2.歯周病の検査

    讃井彰一( Role: Joint author)

    永末書店  2023.2 

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    Responsible for pages:p99-102   Language:Japanese   Book type:Scholarly book

  • ミニレビュー 組織再生を目的としたアメロジェニン研究の現在

    讃井彰一、西村英紀( Role: Sole author)

    日本歯周病学会誌  2019.8 

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    Responsible for pages:p100-102   Language:Japanese   Book type:Scholarly book

  • 第4章 歯周病の検査・診断と治療 ザ・ペリオドントロジー 第3版2019.2.20

    讃井彰一( Role: Joint author)

    永末書店  2019.2 

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    Responsible for pages:p100-102   Language:Japanese   Book type:Scholarly book

  • 「bFGFシグナルのアンタゴニストを標的とした歯周組織再生療法の開発」 歯界展望 特別号2013

    讃井 彰一, 田中麗, 豊田敬介, 福田隆男, 後村亮, 濱地 貴文, 前田 勝正( Role: Joint author)

    医歯薬出版株式会社  2013.5 

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    Language:Japanese   Book type:Scholarly book

  • 「医局紹介:研究プロジェクトの精鋭たち/わが医局のエース」

    讃井彰一、前田勝正( Role: Joint author)

    2011.5 

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    Responsible for pages:ザ・クインテッセンス;30 (5), 200-201   Language:Japanese   Book type:General book, introductory book for general audience

  • DOCK2によるT細胞機能の制御 :臨床免疫

    讃井彰一,福井宣規( Role: Joint author)

    科学評論社  2004.3 

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    Responsible for pages:41巻3号,243-247頁   Language:Japanese   Book type:General book, introductory book for general audience

  • CDMファミリー分子DOCK2による免疫シナプス形成の制御 :細胞工学

    讃井彰一,福井宣規( Role: Joint author)

    秀潤社  2003.8 

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    Responsible for pages:22巻11号,1204-1207頁   Language:Japanese   Book type:General book, introductory book for general audience

  • 免疫応答におけるリンパ球の動態-HCH欠損マウスの情報-.:感染・炎症・免疫

    讃井彰一,福井宣規( Role: Joint author)

    2003.3 

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    Responsible for pages:医薬の門社   Language:Japanese   Book type:General book, introductory book for general audience

  • CDMファミリー分子DOCK2によるリンパ球遊走の制御.:メディカル・サイエンス・ダイジェスト臨時増刊号

    讃井彰一,福井宣規,笹月健彦( Role: Joint author)

    ニューサイエンス社  2002.4 

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    Responsible for pages:33巻1号,52-54頁   Language:Japanese   Book type:General book, introductory book for general audience

  • 日本歯周病学会編 糖尿病患者に対する歯周治療ガイドライン改定第3版

    西村英紀, 青山典生, 稲垣幸司, 梅﨑陽二朗, 讃井彰一, 白方良典, 鈴木茂樹, 高橋慶壮, 富田幸代, 内藤徹, 中川種昭, 長澤敏行, 中島貴子, 二宮雅美, 沼部幸博, 林丈一朗, 水谷幸嗣, 水野智仁, 三辺正人, 山下明子, 山本直史.( Role: Joint author)

    医歯薬出版株式会社  2023.6 

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    Responsible for pages:p102-106   Language:Japanese   Book type:Scholarly book

  • 「Y-box結合タンパク質の骨芽細胞における動態解析」 歯界展望 特別号2013

    福田隆男, 田中麗, 豊田敬介, 讃井 彰一, 武富 孝治, 後村亮, 濱地 貴文, 前田 勝正, 西村 英紀( Role: Joint author)

    医歯薬出版株式会社  2013.5 

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    Language:Japanese   Book type:Scholarly book

  • 「歯周組織細胞群における新規アメロジェニン結合タンパク質のプロテオーム解析」 歯界展望 特別号2013

    田中麗, 豊田敬介, 福田隆男, 讃井 彰一, 後村亮, 濱地 貴文, 前田 勝正( Role: Joint author)

    医歯薬出版株式会社  2013.5 

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    Language:Japanese   Book type:Scholarly book

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Presentations

  • 細胞骨格制御分子を標的とした新規歯周治療法の開発に関する基礎的研究 Invited

    讃井彰一

    第61回春季日本歯周病学会学術大会  2018.6 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:京王プラザホテル、東京都   Country:Japan  

    細胞骨格制御分子を標的とした新規歯周治療法の開発に関する基礎的研究

  • 限局性侵襲性歯周炎患者にエナメルマトリックスデリバティブによる歯周組織再生療法を行った一症例

    讃井彰一,四本かれん,豊田敬介,福田隆男,田中麗,山道研介,西村英紀

    第60回春季日本歯周病学会学術大会  2017.5 

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    Event date: 2017.5

    Language:Japanese  

    Venue:福岡国際会館、福岡市   Country:Japan  

  • Spry2 Downregulation Shifts Macrophages Toward an M2 Phenotype by Stimulation with Interferon γ and Porphyromonas gingivalis Lipopolysaccharide. International conference

    2016.6 

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    Event date: 2016.6 - 2018.6

    Language:English  

    Venue:Seoul, South Korea   Country:Japan  

  • Spry2 Downregulation Shifts Macrophages Toward an M2 Phenotype by Stimulation with Interferon γ and Porphyromonas Gingivalis Lipopolysaccharide. International conference

    讃井 彰一, 福田隆男, 田中麗, 豊田敬介, 山道研介, 西村 英紀

    2016.6 

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    Event date: 2016.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Seoul   Country:Korea, Republic of  

  • Symposium 1: Spry2 is a new therapeutic target for periodontal tissue regeneration. International conference

    The 63rd Annual Meeting of Japanese Association for Dental Research  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • The Effects of Spry2 in Osteoblasts and Gingival Epithelial Cells. International conference

    93rd General Session & Exhibition of the International Association for Dental Research  2015.3 

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    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Sprouty2 regulates cell proliferation and migration in periodontal ligament cells International conference

    93rd General Session & Exhibition of the International Association for Dental Research  2015.3 

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    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Tyrosine 55 Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts through bFGF and EGF Stimulation but Inhibits Proliferation of Gingival Epithelial Cells: Implications for Novel Biological Approach to Periodontal Regeneration.

    62nd Annual Meeting of Japanese Association for Dental Research  2014.12 

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    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 根分岐部病変を伴う慢性歯周炎患者に対し歯根分離および自然挺出にて対応した一症例

    讃井 彰一, 田中麗, 豊田敬介, 福田隆男, 後村亮, 山道研介, 西村 英紀

    第56回 秋季日本歯周病学会学術大会  2013.9 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:前橋市   Country:Japan  

  • Inhibition of Spry2 decreased EGF receptors in gingival epithelial cells. International conference

    10th Asian Pacific Society of Periodontology Meeting  2013.9 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Sprouty2 regulates degradation of EGF receptors in gingival epithelial cells. International conference

    2nd meeting of IADR-APR  2013.8 

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • Sprouty2 regulates osteoblastogenesis via Runx2 signaling. International conference

    Sanui Terukazu, Tanaka Urara, Toyoda Kyosuke, Fukuda Takao, Takaharu Taketomi, Atomura Ryo, Hamachi Takafumi, Maeda Katsumasa

    91nd General Session & Exhibition of the IADR  2013.3 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Inhibition of Sprouty2 Polarizes Macrophages toward M2 Phenotype in Periodontitis Invited International conference

    Terukazu Sanui, Urara Tanaka, Kyosuke Toyoda, Takao Fukuda, Ryo Atomura, Takafumi Hamachi, and Katsumasa Maeda

    2013.3 

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    Event date: 2013.3

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • bFGFシグナルのアンタゴニストを標的とした歯周組織再生療法の開発

    讃井彰一、田中麗、福田隆男、豊田敬介、後村亮、濱地貴文、前田勝正

    第22 回日本歯科医学会総会  2012.11 

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    Event date: 2012.11

    Venue:大阪国際会議場   Country:Japan  

  • YB-1 regulates cell proliferation and differentiation in osteoblasts. International conference

    Terukazu Sanui, Kyosuke Toyoda, Takao Fukuda, Urara Tanaka, Ryou Atomura, Takafumi Hamachi, Katsumasa Maeda

    98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology  2012.9 

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    Event date: 2012.10 - 2012.9

    Country:United States  

  • Periodontal Regenerative Effect by Inhibition of Sprouty2 Protein. International conference

    T. SANUI, U. TANAKA, T. FUKUDA, K. TOYODA, T. TAKETOMI, R. ATOMURA, T. HAMACHI, and K. MAEDA

    2012.9 

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    Event date: 2012.9

    Country:Finland  

  • Suppression of Sprouty2 Induces Periodontal Tissue Regeneration. International conference

    T. SANUI, T. FUKUDA, T. TAKETOMI, T. HAMACHI, and K. MAEDA

    2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Spain  

  • Analysis of Streptococcus mutans Biofilm Proteins Recognized by Salivary IgA. International conference

    Terukazu Sanui and Richard L. Gregory

    The 87th International Association for Dental Research (IADR)  2009.4 

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    Event date: 2009.4

    Country:United States  

    Analysis of Streptococcus mutans Biofilm Proteins Recognized by Salivary IgA.

  • Tリンパ球の細胞高次機能制御におけるCDMファミリー分子DOCK2の役割

    讃井彰一、笹月健彦、福井宣規

    日本免疫学会  2002.12 

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    Presentation type:Oral presentation (general)  

    Venue:第32回日本免疫学会総会・学術集会 東京   Country:Japan  

  • 高親和性科可溶性TCRの樹立とその未知抗原ペプチド同定への応用

    讃井彰一、福井宣規、大野隆真、笹月健彦

    日本免疫学会  2000.11 

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    Venue:第30回日本免疫学会総会・学術集会 仙台   Country:Japan  

  • リンパ球の運動性を制御する分子の同定

    讃井彰一、福井宣規、橋本修、白井俊一、笹月健彦

    日本免疫学会  2001.12 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Fabrication of Gingiva-Derived Stem Cell-Based Scaffold-Free Bone-Like 3D Structures International conference

    Masaaki Toyoda, Shunichi Kajioka, Takao Fukuda, Kentaro Kawakami, Miyu Shida, Chikako Hayashi, Tsukasa Aoki, Tatsuro Zeze, Yuki Nakao, Terukazu Sanui, Fusanori Nishimura

    2024 IADR/AADOCR/CADR General Session & Exhibition  2024.3 

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    Event date: 2024.3

    Language:English  

    Country:United States  

  • Endothelial insulin resistance contributes to the pathogenesis of diabetes-related periodontitis. International conference

    Chikako Hayashi, Masaaki Toyoda, Kentaro Kawakami, Yuki Nakao, Miyu Shida, Takanori Shinjo, Terukazu Sanui, Takao Fukuda, Fusanori Nishimura

    2024 IADR/AADOCR/CADR General Session & Exhibition  2024.3 

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    Event date: 2024.3

    Language:English  

    Country:United States  

  • ヒト歯肉由来幹細胞を用いて作製した骨様立方構造体の解析.

    豊田真顕、梶岡俊一、福田隆男、藤本亮太、川上賢太郎、信太実有、李金鳳、林千華子、中尾雄紀、讃井彰一、中山功一、西村英紀

    第66回秋季日本歯周病学会学術大会  2023.12 

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    Event date: 2023.12

    Language:Japanese  

    Venue:アバンセホール、 佐賀市   Country:Japan  

  • バイオ3Dプリンターを用いた歯肉幹細胞由来骨様立体構造物の作製方法の確立と骨分化能、石灰化度に関する解析.

    豊田真顕、梶岡俊一、福田隆男、川上賢太郎、信太実有、李金鳳、林千華子、中尾雄紀、讃井彰一、西村英紀

    第66回秋季日本歯周病学会学術大会  2023.10 

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    Event date: 2023.10

    Language:Japanese  

    Venue:出島メッセ長崎、 長崎市   Country:Japan  

  • miR-582-5p, that targets Skp1 and suppresses NF-kB signaling-mediated inflammation, is down-regulated in periodontitis and obesity.

    Li Rongzhi, Tomomi Sano, Takao Fukuda, Takanori Shinjyo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Fusanori Nishimura.

    2023.6 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

  • バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦

    豊田真顕、梶岡俊一、川上賢太郎、林千華子、渡邊ゆかり、中尾雄紀、四本かれん、讃井彰一、福田隆男、西村英紀

    令和4年度日本歯周病学会九州五大学 日本臨床歯周病学会九州支部合同研究会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて

    川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀

    令和4年度日本歯周病学会九州五大学 日本臨床歯周病学会九州支部合同研究会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • Endothelial insulin resistance contributes to the exacerbation of diabetes-related periodontitis. International conference

    Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.

    The 108th Annual Meeting of the American Academy of Periodontology  2022.10 

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    Event date: 2022.10

    Language:English  

    Country:United States  

  • Fabrication of stem cell-based scaffold-free bone-like 3D structures. International conference

    Toyoda M, Kajioka S, Fujimoto R, Hayashi C, Kawakami K, Watanabe Y, Nakao Y, Yotsumoto K, Sanui T, Fukuda T, Nakayama K, Nishimura. F.

    The 108th Annual Meeting of the American Academy of Periodontology  2022.10 

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    Event date: 2022.10

    Language:English  

    Country:United States  

  • miR-1260b inhibits periodontal bone loss by targeting ATF6β. International conference

    2022.10 

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    Event date: 2022.10

    Language:English  

    Venue:Phoenix, AZ   Country:United States  

  • Endothelial insulin resistance contributes to the pathogenesis of diabetes-related periodontitis. International conference

    Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Mio Imagawa, Yuki Nishimura, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura.

    2022 IADR/APR General Session & Exhibition  2022.6 

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    Event date: 2022.6

    Language:English  

    Country:China  

  • TNF-a/IFN-a共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する

    渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、中尾雄紀、大和寛明、四本かれん、新城尊徳、岩下未咲、讃井彰一、福田隆男、西村英紀

    2022年度日本歯科保存学会春季学術大会(第156回)  2022.6 

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    Event date: 2022.6

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて

    川上賢太郎、渡邊ゆかり、林千華子、豊田真顕、新城尊徳、讃井彰一、福田隆男、西村英紀

    2022年度日本歯科保存学会春季学術大会(第156回)  2022.6 

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    Event date: 2022.6

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立法構造物作製への挑戦

    豊田真顕、梶岡俊一、福田隆男、渡辺ゆかり、林千華子、川上賢太郎、中尾雄紀、四本かれん、大和寛明、讃井彰一、西村英紀

    第65回春季日本歯周病学会学術大会  2022.6 

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    Event date: 2022.6

    Language:Japanese  

    Venue:東京京王プラザホテル   Country:Japan  

  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果

    林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀

    第65回春季日本歯周病学会学術大会  2022.6 

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    Event date: 2022.6

    Language:Japanese  

    Venue:東京京王プラザホテル   Country:Japan  

  • Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. International conference

    2021.11 

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    Event date: 2021.11

    Language:English  

    Venue:九州大学歯学部   Country:Japan  

  • Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress. International conference

    2021.11 

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    Event date: 2021.11

    Language:English  

    Venue:九州大学歯学部   Country:Japan  

  • 肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯槽骨吸収抑制作用.

    林千華子, 福田隆男, 渡邊ゆかり, 川上賢太郎, 豊田真顕, 中尾雄紀, 四本かれん, 大和寛明,新城尊徳,讃井彰一,西村英紀.

    2021年度日本歯科保存学会秋季学術大会(第155回)  2021.10 

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    Event date: 2021.10 - 2021.11

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • Exosomal miR-1260b derived from TNF-α-treated hGMSCs inhibits periodontal bone loss by targeting ATF6β-mediated regulation of ER stress. International conference

    2021.10 

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    Event date: 2021.10

    Language:English  

    Venue:九州大学医学部百年講堂   Country:Japan  

  • High-fat diet-induced XAF1 exacerbates diabetes by promoting pancreatic β-cell apoptosis. International conference

    2021.10 

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    Event date: 2021.10

    Language:English  

    Venue:九州大学医学部百年講堂   Country:Japan  

  • Exosomes derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression. International conference

    2021.10 

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    Event date: 2021.10

    Language:English  

    Venue:九州大学医学部百年講堂   Country:Japan  

  • ゲラニルゲラニルアセトンとアメロジェニンの歯周組織再生への複合的効果

    大和寛明、讃井彰一、四本かれん、中尾雄紀、渡邊ゆかり、林千華子、相原良亮、岩下未咲、田中麗、福田隆男、西村英紀

    2021年度日本歯科保存学会春季学術大会(第154回)  2021.6 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した抗炎症作用.

    林千華子、福田隆男、渡邊ゆかり、川上賢太郎、豊田真顕、中尾雄紀、四本かれん、大和寛明、新城尊徳、讃井彰一、西村英紀.

    第64回春季日本歯周病学会学術大会  2021.5 

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    Event date: 2021.5 - 2021.6

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • 歯肉幹細胞GMSC由来エクソソームによるCD73を介した免疫制御機構

    渡邊ゆかり、福田隆男、中尾雄紀、林千華子、川上賢太郎、豊田真顕、四本かれん、大和寛明、讃井彰一、西村英紀

    第153回日本歯科保存学会2020年度秋季学術大会  2020.11 

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    Event date: 2020.11

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • 歯肉幹細胞由来エクソソームは、miR-1260bによるRANKL阻害により歯槽骨吸収を抑制する

    中尾雄紀、福田隆男、渡邊ゆかり、林千華子、川上賢太郎、豊田真顕、四本かれん、大和寛明、新城尊徳、田中麗、讃井彰一、西村英紀

    第153回日本歯科保存学会2020年度秋季学術大会  2020.11 

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    Event date: 2020.11

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • Amelogenin down-regulates MHC class II antigen presentation on macrophages. International conference

    Karen Yotsumoto, Terukazu Sanui, Hiroaki Yamato, Urara Tanaka, Yuki Nakao, Chikako Hayashi, Hiroaki Yamato, Yukari Watanabe, Takao Fukuda, Fusanori Nishimura

    JADR, The 68th annual meeting  2020.11 

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    Event date: 2020.11

    Language:English  

    Country:Japan  

  • Exosomes from TNF-α-treated human gingiva-derived MSCs inhibit periodontal bone loss via miR-1260b-mediated RANKL inhibition. International conference

    2020.11 

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    Event date: 2020.11

    Language:English  

    Venue:WEB開催   Country:Japan  

  • Amelogenin suppresses IFNγ-induced MHC class II expression in macrophages. International conference

    2020.11 

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    Event date: 2020.11

    Language:English  

    Venue:WEB開催   Country:United States  

  • Therapeutic potential of exosomes derived from GMSCs in periodontal disease. International conference

    Yuki Nakao, Takao Fukuda, Yukari Watanabe, Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjyo, Urara Tanaka, Terukazu Sanui, Fusanori Nishimura.

    American Academy of Periodontology (AAP), 106th Annual meeting  2020.11 

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    Event date: 2020.11

    Language:English  

    Country:United States  

  • Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells. International conference

    Hiroaki Yamato, Terukazu Sanui, Karen Yotsumoto, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takao Fukuda, Urara Tanaka, Fusanori Nishimura.

    American Academy of Periodontology (AAP), 106th Annual meeting  2020.11 

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    Event date: 2020.11

    Language:English  

    Country:United States  

  • アメロジェニンはマクロファージにおけるCIITAのプロモーターIV領域のユークロマチン化を阻害しIFNγ誘導性誘導性のMHCクラスII抗原提示を抑制する.

    四本かれん、田中麗、讃井彰一、大和寛明、中尾雄紀、渡邊ゆかり、林千華子、福田隆男、西村英紀

    第63回秋季日本歯周病学会春季学術大会  2020.10 

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    Event date: 2020.10

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  • Amelogenin inhibits IFNγ-induced MHC class II expression in macrophages. International conference

    2020.3 

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    Event date: 2020.3

    Language:English  

    Venue:Washington D.C., USA(誌上開催)   Country:United States  

  • Therapeutic potential of exosomes derived from GMSCs in periodontal disease. International conference

    Yuki Nakao, Takao Fukuda, Yukari Watanabe, Chikako Hayashi, Kentaro Kawakami, Masaaki Toyoda, Karen Yotsumoto, Hiroaki Yamato, Takanori Shinjo, Urara Tanaka, Terukazu Sanui, Fusanori Nishimura.

    IADR General Session & Exhibition  2020.3 

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    Event date: 2020.3

    Language:English  

    Country:United States  

  • 胃潰瘍治療薬テプレノンとアメロジェニンによる歯周組織再生誘導の可能性

    大和寛明,讃井彰一,四本かれん,中尾雄紀,渡邊ゆかり,福田隆男,田中麗,西村英紀

    令和元年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:アクロス福岡、福岡市   Country:Japan  

  • アメロジェニンはマクロファージによるIFNγ誘導性MHCクラスⅡの抗原提示を抑制する

    四本かれん、田中麗、讃井彰一、大和寛明、中尾雄紀、渡邊ゆかり、林千華子、福田隆男、西村英紀

    令和元年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:アクロス福岡、福岡市   Country:Japan  

  • 歯肉幹細胞由来エクソソーム由来miR-1260bはWnt5aを介して歯根膜細胞におけるRANKL発現を抑制する。

    中尾雄紀、福田隆男、渡邊ゆかり、林千華子、四本かれん、大和寛明、田中麗、讃井彰一、西村英紀

    第151回秋季日本歯科保存学会秋季学術大会  2019.11 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡国際会議場、福岡市   Country:Japan  

  • アメロジェニンはマクロファージにおけるIFNγ誘導性MHCクラスⅡ分子の発現を抑制する。

    四本かれん、田中麗、讃井彰一、大和寛明、中尾雄紀、渡邊ゆかり、林千華子、福田隆男、西村英紀

    第62回秋季日本歯周病学会学術大会  2019.10 

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    Event date: 2019.10 - 2019.6

    Language:Japanese  

    Venue:西日本総合展示場・北九州国際会議場、北九州市   Country:Japan  

  • アメロジェニンはマクロファージによる抗原提示を抑制させる。

    四本かれん、田中麗、讃井彰一、大和寛明、中尾雄紀、渡邊ゆかり、福田隆男、西村英紀

    第150回日本歯科保存学会春季学術大会  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Venue:石川県立音楽堂、金沢市   Country:Japan  

  • アメロジェニンおよび胃潰瘍治療薬テプレノンが歯根膜細胞機能に与える影響

    大和寛明、讃井彰一、四本かれん、中尾雄紀、渡邊ゆかり、福田隆男、田中麗、西村英紀

    第150回日本歯科保存学会春季学術大会  2019.6 

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    Event date: 2019.6

    Language:Japanese  

    Venue:石川県立音楽堂、金沢市   Country:Japan  

  • 歯肉幹細胞由来エクソソームは歯根膜細胞の RANKL 発現を抑制する。

    中尾雄紀、福田隆男、渡邊ゆかり、林千華子、四本かれん、大和寛明、田中麗、讃井彰一、西村英紀

    第62回春季日本歯周病学会学術大会  2019.5 

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    Event date: 2019.5

    Language:Japanese  

    Venue:神奈川県民ホール、横浜市   Country:Japan  

  • SPOCK-1 upregulation is a novel epithelial mesenchymal transition (EMT) inducer in calcium channel blocker-induced gingival overgrowth.

    Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Taiki Sanada, Takao Fukuda, Misaki Iwashita, Terukazu Sanui, Fusanori Nishimura

    2019.5 

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    Event date: 2019.5

    Language:English  

    Country:Japan  

  • SPOCK-1 is a novel epithelial mesenchymal transition (EMT) inducer in calcium channel blocker-induced gingival overgrowth. International conference

    Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Taiki Sanada, Takao Fukuda, Misaki Iwashita, Terukazu Sanui, Fusanori Nishimura

    Kyudai Oral Bioscience & OBT Research Center Joint International Symposium  2019.3 

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    Event date: 2019.3

    Language:English  

    Country:Japan  

  • SPOCK-1 is a novel epithelial mesenchymal transition (EMT) inducer in drug induced gingival overgrowth. International conference

    Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Taiki Sanada, Takao Fukuda, Misaki Iwashita, Terukazu Sanui, Fusanori Nishimura

    Korean Academy of Periodontology (KAP)  2019.3 

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    Event date: 2019.3

    Language:English  

    Country:Korea, Republic of  

  • 歯肉幹細胞由来エクソソームによる抗炎症性マクロファージ誘導機序の検討 ~間葉系幹細胞培養上清の有する抗炎症作用に注目して~

    中尾雄紀,福田隆男,讃井彰一,田中麗,渡邊ゆかり,大和寛明,四本かれん,西村英紀

    平成30年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:アクロス福岡、福岡市   Country:Japan  

  • The Role of Proteoglycans in Drug Induced Gingival Overgrowth (DIGO)

    Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Taiki Sanada, Takao Fukuda, Misaki Iwashita, Terukazu Sanui, Fusanori Nishimura

    2018.11 

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    Event date: 2018.11

    Language:English  

    Country:Japan  

  • 歯肉幹細胞由来エクソソームによる抗炎症性マクロファージ誘導機序の検討

    中尾雄紀,福田隆男,讃井彰一,田中麗,渡邊ゆかり,大和寛明,四本かれん,西村英紀

    第61回秋季日本歯周病学会学術大会  2018.7 

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    Event date: 2018.7

    Language:Japanese  

    Venue:リーガロイヤルホテル大阪、大阪市   Country:Japan  

  • Effect of amelogenin on antigen presentation in macrophages. International conference

    Urara Tanaka, Karen Yotsumoto, Terukazu Sanui, Takao Fukuda, Hiroaki Yamato, Yuki Nakao, Fusanori Nishimura

    96th General Session & Exhibition of the IADR  2018.7 

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    Event date: 2018.7

    Language:English  

    Country:United Kingdom  

  • 炎症脂肪/歯周組織における抗炎症分子の探索研究

    眞田大樹、佐野朋美、福田隆男、岩下未咲、山下明子、藤田剛、讃井彰一、栗原英見、西村英紀

    第148回日本歯科保存学会2018年度春季学術大会  2018.6 

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    Event date: 2018.6

    Language:Japanese  

    Venue:横浜みなとみらいホール、横浜市   Country:Japan  

  • The role of proteoglycans in the pathogenesis of drug induced gingival overgrowth (DIGO).

    Rehab Alshargabi, Aiko Takano, Akiko Yamashita, Misaki Iwashita, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura

    2018.6 

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    Event date: 2018.6

    Language:Japanese  

    Country:Japan  

  • アンジオポエチン様タンパク質2は骨芽細胞分化のpositive regulatorとして機能する。

    高野愛子、福田隆男、新城尊徳、岩下未咲、竹下正章、Rehab Alshargabi、讃井彰一、西村英紀

    日本歯周病学会60周年記念京都大会  2017.12 

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    Event date: 2017.12

    Language:Japanese  

    Venue:国立京都国際会館、京都市   Country:Japan  

  • The role of SPOCK-1 in Drug induced gingival overgrowth (DIGO)

    2017.12 

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    Event date: 2017.12

    Language:English  

    Country:Japan  

  • Microarray analysis of U937 monocytic cells stimulated with amelogenin. International conference

    Urara Tanaka, Karen Yotsumoto, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Fusanori Nishimura

    Penn Periodontal Conference 2017  2017.6 

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    Event date: 2017.6

    Language:English  

    Country:Japan  

  • 歯周炎モデルマウスにおける歯槽骨吸収及び破骨細胞分化へのDecitabineの効果

    田中麗、讃井彰一、福田隆男、西村英紀

    第146回日本歯科保存学会2017年度春季学術大会  2017.6 

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    Event date: 2017.6

    Language:Japanese  

    Venue:リンクステーションホール青森 青森市   Country:Japan  

  • アメロジェニンが有する抗炎症効果の機序解明

    山道研介、福田隆男、讃井彰一、豊田敬介、田中麗、西村英紀

    平成28年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会  2016.10 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎県歯科医師会館、長崎市   Country:Japan  

  • 骨組織におけるアンジオポエチン様タンパク質2の役割の機能解析

    高野愛子、福田隆男、新城尊徳、岩下未咲、讃井彰一、山道研介、竹下正章、西村英紀

    第145回日本歯科保存学会2016年度秋季学術大会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:キッセイ文化ホール、松本市   Country:Japan  

  • IL-17Aは3T3-L1脂肪細胞におけるTNF-α誘導性IL-6・CCL20産生を相乗的に増強する。

    佐野朋美、新城尊徳、岩下未咲、山下明子、讃井彰一、西村英紀

    第145回日本歯科保存学会2016年度秋季学術大会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:キッセイ文化ホール、松本市   Country:Japan  

  • Decitabineによる歯周炎モデルマウスにおける歯槽骨吸収抑制効果の検討

    田中麗、讃井彰一、福田隆男、西村英紀

    第59回秋季日本歯周病学会学術大会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:朱鷺メッセ 新潟コンベンションセンター、新潟市   Country:Japan  

  • Spry2 knockdown enhances proliferation and migration but reduces differentiation of periodontal ligament cells through bFGF and EGF stimulation. International conference

    Hajime Akiyama, Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Kensuke Yamamichi, Takaharu Taketomi, Fusanori Nishimura.

    94th General Session & Exhibition of the International Association for Dental Research  2016.6 

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    Event date: 2016.6 - 2018.6

    Language:English  

    Country:Japan  

  • Grp78 is crucial for cell migration induced by amelogenin in a human periodontal ligament cells. International conference

    Kyosuke Toyoda, Hajime Akiyama, Takao Fukuda, Terukazu Sanui, Urara Tanaka, Takaharu Taketomi, Fusanori Nishimura

    94th General Session & Exhibition of the International Association for Dental Research  2016.6 

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    Event date: 2016.6 - 2018.6

    Language:English  

    Country:Japan  

  • Amelogenin Modulates Macrophage Phenotype During Inflammatory Responses. International conference

    Kensuke Yamamichi, Hajime Akiyama, Takao Fukuda, Terukazu Sanui, Kyosuke Toyoda, Urara Tanaka, Takaharu Taketomi, Fusanori Nishimura

    94th General Session & Exhibition of the International Association for Dental Research  2016.6 

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    Event date: 2016.6 - 2018.6

    Language:English  

    Country:Japan  

  • 骨組織におけるアンジオポエチン様タンパク質2の役割の解明

    高野愛子、福田隆男、新城尊徳、岩下未咲、讃井彰一、山道研介、竹下正章、西村英紀

    第144回日本歯科保存学会2016年度春季学術大会  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:栃木県総合文化センター   Country:Japan  

  • 歯周病感染器官培養モデルを用いた抗菌薬の効果に関する研究

    竹下正章、原口晃、三浦真由美、濱地貴文、福田隆男、讃井彰一、西村英紀

    第59回春季日本歯周病学会学術大会  2016.5 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:かごしま県民交流センター、鹿児島市   Country:Japan  

  • Molecular basis of amelogenin-induced periodontal tissue regeneration. Invited International conference

    Takao Fukuda, Terukazu Sanui, Kyosuke Toyoda, Urara Tanaka, Kensuke Yamamichi, Ryo Atomura, Hajime Akiyama, Fusanori Nishimura

    2016.2 

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    Event date: 2016.2 - 2018.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Molecular basis of amelogenin-induced periodontal tissue regeneration International conference

    2016.2 

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    Event date: 2016.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • ヒト歯根膜幹細胞/前駆細胞株の細胞遊走時に及ぼす分子機構

    豊田敬介, 福田隆男, 讃井 彰一, 山道研介, 後村亮, 西村 英紀

    2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会  2015.11 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:文京シビックホール、東京都   Country:Japan  

  • アメロジェニンが炎症過程におけるマクロファージの形質転換におよぼす影響

    山道研介, 福田隆男, 讃井 彰一, 豊田敬介, 後村亮, 西村 英紀

    2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会  2015.11 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:文京シビックホール、東京都   Country:Japan  

  • Spry2抑制によるM1マクロファージへの分化抑制メカニズムの解析

    後村亮, 讃井 彰一, 福田隆男, 豊田敬介, 山道研介, 西村 英紀

    2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会  2015.11 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:文京シビックホール、東京都   Country:Japan  

  • アメロジェニンが有する抗炎症効果の機序解明

    山道研介, 福田隆男, 讃井 彰一, 豊田敬介, 後村亮, 西村 英紀

    平成27年度日本臨床歯周病学会九州支部・日本歯周病学会九州五大学合同研修会  2015.11 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:アクロス福岡、福岡市   Country:Japan  

  • Grp78 Is Critical For Amelogenin-induced Cell Migration In PDLSCs International conference

    The 63rd Annual Meeting of Japanese Association for Dental Research  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Inhibition of Sprouty2 Regulates Cell Functions in Periodontal Ligament Cells International conference

    Penn Periodontal Conference 2015  2015.6 

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    Event date: 2015.6 - 2015.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Grp78 is critical for amelogenin-induced cell migration in PDL cells International conference

    Penn Periodontal Conference 2015  2015.6 

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    Event date: 2015.6 - 2015.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Spry2がPorphyromonas gingivalis LPS刺激マクロファージの分化に及ぼす影響について

    後村亮, 讃井 彰一, 福田隆男, 豊田敬介, 山道研介, 田中麗, 西村 英紀

    日本歯科保存学会 2015年度春季学術大会  2015.6 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州国際会議場、北九州市   Country:Japan  

  • Spry2がPorphyromonas gingivalis LPS刺激マクロファージの分化に及ぼす影響について

    後村亮, 讃井 彰一, 福田隆男, 豊田敬介, 山道研介, 田中麗, 西村 英紀

    日本歯科保存学会 2015年度春季学術大会  2015.6 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州国際会議場、北九州市   Country:Japan  

  • 歯周病感染器官培養モデルを用いた抗菌薬の効果に関する研究

    竹下正章, 讃井 彰一, 西村 英紀

    第142回日本歯科保存学会 2015年度春季学術大会  2015.6 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州国際会議、北九州市   Country:Japan  

  • マクロファージにおけるアメロジェニン刺激の影響の網羅的遺伝子解析

    山道研介, 福田隆男, 讃井 彰一, 後村亮, 豊田敬介, 田中麗, 西村 英紀

    日本歯科保存学会 2015年度春季学術大会  2015.6 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州国際会議場、北九州市   Country:Japan  

  • 新規に同定したアメロジェニン会合蛋白Grp78がヒト歯根膜幹細胞/前駆細胞株の機能に及ぼす役割の検討

    豊田敬介, 後村亮, 福田隆男, 讃井 彰一, 山道研介, 田中麗, 西村 英紀

    平成27年度 第58回春季日本歯周病学会学術大会  2015.5 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:幕張メッセ 国際会議場、千葉市   Country:Japan  

  • Grp78 is Essential for Amelogenin-Induced Cell Migration in PDLSCs. International conference

    93rd General Session & Exhibition of the International Association for Dental Research  2015.3 

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    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Grp78 is critical for amelogenin-induced cell migration in a human periodontal ligament stem/progenitor cell line.

    Kyudai Oral Bioscience (KOB) 2015  2015.2 

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    Event date: 2015.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Sprouty2 Regulates Cell Proliferation and Migration in Periodontal Ligament Cells.

    2015.2 

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    Event date: 2015.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Kyosuke Toyoda, Takao Fukuda, Ryo Atomura, Terukazu Sanui, Urara Tanaka, Takaharu Taketomi, Kensuke Yamamichi and Fusanori Nishimura Amelogenin induces cell migration via Grp78 in PDL cells.

    62nd Annual Meeting of Japanese Association for Dental Research  2014.12 

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    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 歯周病感染器官培養モデルを用いた抗菌療法確立を目指す基礎研究

    竹下正章, 讃井 彰一, 西村 英紀

    平成 26 年度日本歯周病学会五大学・日本臨床歯周病学会九州支部合同研修会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:アクロス福岡、福岡市   Country:Japan  

  • アメロジェニンの生物学的活性の機序解明

    豊田敬介, 後村亮, 福田隆男, 讃井 彰一, 山道研介, 田中麗, 西村 英紀

    平成26年度 日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研修会  2014.11 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:アクロス福岡、福岡市   Country:Japan  

  • 歯周病感染器官培養モデルを用いた抗菌療法確立を目指す基礎研究

    竹下正章, 讃井 彰一, 西村 英紀

    第 104 回日本歯科保存学会秋季学術大会  2014.10 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山形テルサ、山形市   Country:Japan  

  • Aggregatibacter actinomycetemcomitans は菌体外にDNA-LPS 複合体を産生し、その病原性はLPS単体よりも低い

    竹下正章, 讃井 彰一, 西村 英紀

    第58日本歯周病学会秋季学術大会  2014.10 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸市国際展示場、神戸市   Country:Japan  

  • 新規に同定したアメロジェニン会合分子GRP78がヒト歯根膜細胞機能に果たす役割の検討

    豊田敬介, 後村亮, 福田隆男, 讃井 彰一, 山道研介, 田中麗, 西村 英紀

    第58日本歯周病学会秋季学術大会  2014.10 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸市国際展示場、神戸市   Country:Japan  

  • マクロファージにおけるアメロジェニン刺激が関与するpathwayの検討

    後村亮, 豊田敬介, 福田隆男, 讃井 彰一, 西村 英紀

    140回 日本歯科保存学会2014年度春季学術大会  2014.6 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:滋賀県立劇場びわ湖ホール、大津市   Country:Japan  

  • 新規アメロジェニン会合分子GRP78がヒト歯根膜細胞に及ぼす影響

    豊田敬介, 田中麗, 福田隆男, 讃井 彰一, 後村亮, 山道研介, 西村 英紀

    140回 日本歯科保存学会2014年度春季学術大会  2014.6 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:滋賀県立劇場びわ湖ホール、大津市   Country:Japan  

  • Spry2を標的とした歯周組織再生療法確立を目指す基礎研究

    田中麗, 豊田敬介, 讃井 彰一, 福田隆男, 後村亮, 山道研介, 西村 英紀

    第57日本歯周病学会春季学術大会  2014.5 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長良川国際会議場、岐阜市   Country:Japan  

  • プロテオーム解析によるアメロジェニン会合分子の検討

    福田隆男, 豊田敬介, 田中麗, 讃井 彰一, 後村亮, 山道研介, 西村 英紀

    第139回 日本歯科保存学会 秋季学術大会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:秋田市   Country:Japan  

  • 新規アメロジェニン会合分子Grp78がヒト歯根膜細胞に及ぼす影響

    豊田敬介, 田中麗, 福田隆男, 讃井 彰一, 後村亮, 山道研介, 西村 英紀

    平成25年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会  2013.11 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州市九州歯科大学   Country:Japan  

  • フレアーアウトを伴う歯周炎患者に歯周矯正を行った一症例

    福田隆男, 豊田敬介, 田中麗, 讃井 彰一, 後村亮, 山道研介, 西村 英紀

    第56回 秋季日本歯周病学会学術大会  2013.9 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:前橋市   Country:Japan  

  • Grp78 mediates endocytosis of amelogenin International conference

    10th Asian Pacific Society of Periodontology Meeting  2013.9 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Sprouty2 controls cell proliferation and migration in periodontal ligament cells. International conference

    10th Asian Pacific Society of Periodontology Meeting  2013.9 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Identification of novel ameogenin-binding proteins by proteomics analysis International conference

    10th Asian Pacific Society of Periodontology Meeting  2013.9 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Proteomic approach to identify the receptor for amelogenin. International conference

    2nd meeting of IADR-APR  2013.8 

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • The effect of Grp78 on cellular uptake of amelogenin. International conference

    2nd meeting of IADR-APR  2013.8 

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • Spry2 regulates cell proliferation and migration in periodontal ligament cells. International conference

    2nd meeting of IADR-APR  2013.8 

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  • アメロジェニン会合タンパクのプロテオーム解析

    豊田敬介, 田中麗, 福田隆男, 讃井 彰一, 後村亮, 濱地 貴文, 前田 勝正, 西村 英紀

    第56回春季日本歯周病学会学術大会  2013.5 

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    Event date: 2013.5 - 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:タワーホール船堀   Country:Japan  

  • The effects of Sprouty2 in periodontal ligament cell International conference

    Tanaka Urara, Toyoda Kyosuke, Sanui Terukazu, Fukuda Takao, Takaharu Taketomi, Atomura Ryo, Hamachi Takafumi, Maeda Katsumasa

    91nd General Session & Exhibition of the IADR  2013.3 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • Proteomic approach to understanding endocytosis of amelogenin International conference

    Fukuda Takao, Toyoda Kyosuke, Tanaka Urara, Sanui Terukazu, Takaharu Taketomi, Atomura Ryo, Hamachi Takafumi, Maeda Katsumasa

    91nd General Session & Exhibition of the IADR  2013.3 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • The Role of Sprouty2 Protein in Osteoblasts and Periodontal Ligament Cells International conference

    Urara Tanaka, Kyosuke Toyoda, Terukazu Sanui, Takao Fukuda, Ryo Atomura, Takafumi Hamachi, and Katsumasa Maeda

    2013.3 

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    Event date: 2013.3

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Proteomic Approach to Understanding Endocytosis of Amelogenin International conference

    Kyosuke Toyoda, Urara Tanaka, Takao Fukuda, Terukazu Sanui, Ryo Atomura, Takafumi Hamachi and Katsumasa Maeda

    2013.3 

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    Event date: 2013.3

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • アメロジェニン結合タンパクのプロテオーム解析 International conference

    田中 麗,讃井彰一,福田隆男,豊田敬介,後村 亮,濱地貴文,前田勝正

    第22 回日本歯科医学会総会  2012.11 

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    Event date: 2012.11

    Venue:大阪国際会議場   Country:Japan  

  • Y-box結合タンパク質の骨芽細胞における動態解析

    福田 隆男, 豊田 敬介, 讃井 彰一, 田中 麗, 後村 亮, 濱地 貴文, 前田 勝正

    第22 回日本歯科医学会総会  2012.11 

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    Event date: 2012.11

    Language:Japanese  

    Venue:大阪国際会議場   Country:Japan  

  • Sprouty2 could be new therapeutic targets for periodontal tissue regeneration. International conference

    Kyosuke Toyoda, Urara Tanaka, Terukazu Sanui, Takao Fukuda, Ryou Atomura, Takafumi Hamachi, Katsumasa Maeda

    98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology  2012.9 

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    Event date: 2012.9 - 2012.10

    Country:United States  

  • Proteome analysis of amelogenin-binding proteins. International conference

    Urara Tanaka, Takao Fukuda, Terukazu Sanui, Kyosuke Toyoda, Takaharu Taketomi, Ryo Atomura, Takafumi Hamachi and Katsumasa Maeda

    2012.9 

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    Event date: 2012.9 - 2012.11

    Country:Finland  

  • Knockdown of YB-1 protein induces osteoblastic differentiation. International conference

    Takao Fukuda, Kyousuke Toyoda, Terukazu Sanui, Urara Tanaka, Takaharu Taketomi, Ryou Atomura, Takafumi Hamachi and Katsumasa Maeda

    2012.9 

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    Event date: 2012.9 - 2012.11

    Country:Finland  

  • Zoledronic acids enhance lipopolysaccharide-stimulated pro-inflammatory activation in macrophages. International conference

    D. MURATSU, D. YOSHIGA, T. TAKETOMI, T. ONIMURA, T. SANUI and S. NAKAMURA

    2012.9 

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    Event date: 2012.9

    Country:Finland  

  • Sprouty2 controls osteoblast proliferation and differentiation via FGF signaling. International conference

    T. ONIMURA, T. TAKETOMI, D. YOSHIGA, D. MURATSU, T. SANUI, T. FUKUDA, and S. NAKAMURA

    2012.9 

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    Event date: 2012.9

    Country:Finland  

  • Sprouty2を標的とした歯周組織再生の可能性

    田中麗、讃井彰一、福田隆男、豊田敬介、濱地貴文、前田勝正

    第55回春季日本歯周病学会学術大会  2012.5 

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    Event date: 2012.5

    Presentation type:Oral presentation (general)  

    Venue:札幌コンベンションセンター   Country:Japan  

  • Sprouty2分子を標的とした歯周組織再生の可能性

    田中麗、讃井彰一、福田隆男、豊田敬介、濱地貴文、前田勝正

    平成23年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会  2011.11 

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    Event date: 2011.11

    Presentation type:Oral presentation (general)  

    Venue:長崎県歯科医師会館   Country:Japan  

  • ヒトY-box結合タンパク(YB-1)の骨芽細胞における細胞動態解析

    福田隆男、田中麗、讃井彰一、豊田敬介、久保田祥平、武富孝治、濱地貴文、前田勝正

    第54回日本歯周病学会秋季学術大会  2011.9 

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    Event date: 2011.9

    Presentation type:Oral presentation (general)  

    Venue:海峡メッセ下関   Country:Japan  

  • Sprouty2 controls the palate mesenchymal cell proliferation via FGF signaling. International conference

    K. MATSUMURA, T. TAKETOMI, K. YOSHIZAKI, S. ARAI, M. MORIYAMA, T. MAEHARA, T. SANUI, D. YOSHIGA, A. YOSHIMURA, and S. NAKAMURA.

    The 89th General Session and Exhibition of the IADR  2011.3 

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    Event date: 2011.3

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Characterization of the amelogenin binding proteins. International conference

    Takao Fukuda, Terukazu Sanui, Takaharu Taketomi, Takafumi Hamachi and Katsumasa Maeda

    96th AAP annual meeting  2010.11 

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    Event date: 2010.10 - 2010.11

    Presentation type:Oral presentation (general)  

    Country:United States  

  • YB-1 is important for amelogenin induced periodontal regeneration. International conference

    T. FUKUDA, T. SANUI, T. TAKETOMI, T. HAMACHI and K. MAEDA

    The 88th International Association for Dental Research (IADR)  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Spain  

  • Spry2 deficient mice exhibit cleft palate. International conference

    K. MATSUMURA, T. TAKETOMI, K. YOSHIGA, S. ARAI, T. SANUI and S. NAKAMURA

    The 88th International Association for Dental Research (IADR)  2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Spain  

  • Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation. International conference

    T. TAKETOMI, D. YOSHIGA, K. MITSUYASU, T. SANUI, T. FUKUDA, A. YOSHIMURA and S. NAKAMURA

    2010.7 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Spain  

  • Analysis of the molecular mechanisms of periodontal regeneration by EMD International conference

    Takao Fukuda, Terukazu Sanui, Takaharu Taketomi, Takafumi Hamachi, Katsumasa Maeda

    2010.2 

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    Event date: 2010.2

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Analysis of the novel protein bound to amelogenin in periodontal tissue cells. International conference

    Fukuda, T., Sanui, T., Taketomi, T., Hamachi, T., Maeda, K.

    The 50th Anniversary of Korean Academy of Conservative Dentistry, 2009 Autumn Scientific Meeting (the 132nd) and The 11th Joint-Scientific Meeting between KACD & JSCD  2009.11 

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    Event date: 2009.11

    Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  • 歯周組織細胞群における新規アメロジェニン結合タンパク質の検索

    福田隆男、讃井彰一、武富孝治、後藤英文、濱地貴文、前田勝正

    日本歯周病学会  2009.5 

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    Event date: 2009.5

    Venue:岡山コンベンションセンター   Country:Japan  

  • 胸腺でのT細胞レパートリー形成が末梢の免疫応答に及ぼす質的影響

    大野隆真、福井宣規、讃井彰一、笹月健彦

    日本免疫学会  1999.12 

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    Venue:第29回日本免疫学会総会・学術集会 京都   Country:Japan  

  • 選択に関わる抗原ペプチドの構造によって影響されるT細胞レパートリーの多様性と特異性

    福井宣規、大野隆真、讃井彰一、笹月健彦

    日本免疫学会  1999.12 

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    Venue:第29回日本免疫学会総会・学術集会 京都   Country:Japan  

  • 造血系細胞特異的に発現するCDMファミリー遺伝子の単離とその機能解析

    福井宣規、大野隆真、讃井彰一、笹月健彦

    日本免疫学会  2000.11 

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    Venue:第30回日本免疫学会総会・学術集会 仙台   Country:Japan  

  • 自然発症末梢神経特異的自己免疫疾患マウスモデルの樹立とその発症におけるT細胞レパートリー選択の関与

    大野隆真、福井宣規、讃井彰一、笹月健彦

    日本免疫学会  2000.11 

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    Venue:第30回日本免疫学会総会・学術集会 仙台   Country:Japan  

  • 単一MHC/ペプチド複合体上で分化したT細胞が末梢で自己及びアロMHC分子の拘束下で認識する抗原ペプチドの同定

    大野隆真、福井宣規、讃井彰一、笹月健彦

    日本免疫学会  2001.12 

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    Venue:第31回日本免疫学会総会・学術集会 大阪   Country:Japan  

  • DOCK2はNKT細胞の分化に必須である

    國崎祐也、讃井彰一、福井宣規

    日本免疫学会  2003.12 

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    Venue:第33回日本免疫学会総会・学術集会 福岡   Country:Japan  

  • 生物学的歯髄鎮静法確立の試み 炎症惹起分子の同定から歯内-歯周病変モデルでの検証まで

    川上 賢太郎, 渡邊 ゆかり, 林 千華子, 豊田 真顕, 新城 尊徳, 讃井 彰一, 福田 隆男, 西村 英紀

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2022.10  (NPO)日本歯科保存学会

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  • 歯肉幹細胞由来エクソソーム内包miR-1260bによる小胞体ストレス応答制御を介した歯周炎骨吸収抑制効果

    林 千華子, 福田 隆男, 渡邊 ゆかり, 川上 賢太郎, 豊田 真顕, 中尾 雄紀, 四本 かれん, 大和 寛明, 新城 尊徳, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2022.5  (NPO)日本歯周病学会

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  • 幹細胞を用いたscaffold freeの骨様組織3D構造体の作製(Fabrication of stem cell-based scaffold-free bone-like 3D structures)

    Toyoda Masaaki, Kajioka Shunichi, Fujimoto Ryota, Hayashi Chikako, Kawakami Kentarou, Watanabe Yukari, Nakao Yuki, Yotumoto Karen, Sanui Terukazu, Fukuda Takao, Nakayama Koichi, Nishimura Fusanori

    日本歯周病学会会誌  2022.12  (NPO)日本歯周病学会

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  • 内皮のインスリン抵抗性は糖尿病関連歯周炎の増悪に関与する(Endothelial insulin resistance contributes to the exacerbation of diabetes-related periodontitis)

    Zeze Tatsuro, Shinjo Takanori, Sato Kohei, Imagawa Mio, Nishimura Yuki, Iwashita Misaki, Fukuda Takao, Sanui Terukazu, Nishimura Fusanori

    日本歯周病学会会誌  2022.12  (NPO)日本歯周病学会

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  • ヒト歯髄細胞由来マイクロベジクル含有PKRを標的とした歯髄鎮静薬および歯内・歯周病変モデルの作成に向けて

    川上 賢太郎, 渡邊 ゆかり, 林 千華子, 豊田 真顕, 新城 尊徳, 讃井 彰一, 福田 隆男, 西村 英紀

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2022.5  (NPO)日本歯科保存学会

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  • バイオ3Dプリンターを用いた歯肉幹細胞由来骨様立体構造物の作製方法の確立と骨分化能,石灰化度に関する解析

    豊田 真顕, 梶岡 俊一, 福田 隆男, 川上 賢太郎, 信太 実有, 李 金鳳, 林 千華子, 中尾 雄紀, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2023.10  (NPO)日本歯周病学会

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  • バイオ3Dプリンターを用いた、間葉系幹細胞からの骨様立体構造物作製への挑戦

    豊田 真顕, 梶岡 俊一, 福田 隆男, 渡邊 ゆかり, 林 千華子, 川上 賢太郎, 中尾 雄紀, 四本 かれん, 大和 寛明, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2022.5  (NPO)日本歯周病学会

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  • エムドゲインのプロテオミクス

    福田 隆男, 川上 賢太郎, 王 紫瑜, 肖 萌, 豊田 真顕, 林 千華子, 信太 実有, 李 金鳳, Mwannes Ahmad, 讃井 彰一, 西村 英紀

    日本歯周病学会会誌  2024.4  (NPO)日本歯周病学会

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  • アメロジェニンが他家皮膚移植モデルマウスの拒絶反応に及ぼす影響

    信太 実有, 讃井 彰一, 西村 優輝, 林 千華子, 川上 賢太郎, 豊田 真顕, 新城 尊徳, 福田 隆男, 西村 英紀

    日本歯周病学会会誌  2024.4  (NPO)日本歯周病学会

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  • TNF-α/IFN-α共刺激した歯肉幹細胞由来エクソソームはCD73とCD5Lを介して抗炎症性M2マクロファージを誘導する

    渡邊 ゆかり, 林 千華子, 川上 賢太郎, 豊田 真顕, 中尾 雄紀, 大和 寛明, 四本 かれん, 新城 尊徳, 岩下 未咲, 讃井 彰一, 福田 隆男, 西村 英紀

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2022.5  (NPO)日本歯科保存学会

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  • Skp1を標的としNF-κBシグナルを介した炎症を抑制するmiR-582-5pは歯周炎と肥満において抑制されている(miR-582-5p, that targets Skpl and suppresses NF-κB signaling-mediated inflammation, is down-regulated in periodontitis and obesity)

    Li Rongzhi, Sano Tomomi, Fukuda Takao, Shinjo Takanori, Iwashita Misaki, Yamashita Akiko, Sanui Terukazu, Nishimura Fusanori

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集  2023.5  (NPO)日本歯科保存学会

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  • ATF6βを標的としたmiR-1260bの歯周病による量吸収抑制効果(miR-1260b inhibits periodontal bone loss by targeting ATF6β)

    Hayashi Chikako, Kawakami Kentaro, Toyoda Masaaki, Watanabe Yukari, Nakao Yuki, Yotsumoto Karen, Yamato Hiroaki, Shinjo Takanori, Sanui Terukazu, Fukuda Takao, Nishimura Fusanori

    日本歯周病学会会誌  2022.12  (NPO)日本歯周病学会

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MISC

  • 口腔内細菌および腸内細菌が増悪させる全身疾患の新知見

    讃井彰一

    福岡県歯科医師会「歯界時報」学術レポート   2022.9

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  • EMD Science Flash「Emdogain Gelの炎症抑制効果」

    讃井彰一, 四本かれん, 西村英紀.

    ストローマンジャパン   2020.9

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    Language:Japanese  

  • ミニレビュー 組織再生を目的としたアメロジェニン研究の現在

    讃井彰一、西村英紀

    日本歯周病学会誌   2019.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ザ・ペリオドントロジー第3版 第4章 歯周病の検査・診断と治療

    讃井彰一, 四本かれん, 西村英紀.

    永末書店   2019.2

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    Language:Japanese  

  • 細胞骨格制御分子を標的とした新規歯周治療法の開発に関する基礎的研究

    讃井彰一

    日本歯周病学会誌   2018.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: doi.org/10.2329/perio.60.117

  • Diabetes as a risk factor for periodontal disease-plausible mechanisms. Reviewed

    Polak D, Sanui T, Nishimura F, Shapira L.

    Periodontology 2000   2020.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: doi: 10.1111/prd.12298.

  • Glucose-regulated protein78: A therapeutic target for amelogenin-induced periodontal tissue regeneration.

    Fukuda T and Sanui T*, Toyoda K, Tanaka U, Yamamichi K, Taketomi T, Nishimura F.

    Single-Cell Biology   2016.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: doi:10.4172/2168-9431.1000137

  • New therapeutic strategy for regenerating periodontal tissue based on the combination of amelogenin and reapplications of existing Grp78 inducer.

    Fukuda T and Sanui T*, Toyoda K, Tanaka U, Yamamichi K, Taketomi T, Nishimura F.

    Journal of Cell Signaling   2016.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: doi:10.4172/jcs.1000118.

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Professional Memberships

  • Japanese Society for Immunology

  • International Association for Dental Research

  • Japan Asssociation of Dental Research

  • Japanese Society of Periodontology

  • Japanese Society of Conservative Dentistry

Committee Memberships

  • Steering committee member   Domestic

    2023.4 - 2025.3   

  • 日本歯周病学会   国際交流委員   Domestic

    2023.4 - 2025.3   

  • Steering committee member   Domestic

    2021.4 - 2023.3   

  • Steering committee member   Domestic

    2021.4 - 2023.3   

  • 日本歯周病学会   ペリオドンタルメディシン委員   Domestic

    2021.4 - 2023.3   

  • 日本歯周病学会   国際交流委員   Domestic

    2021.4 - 2023.3   

  • Steering committee member   Domestic

    2019.4 - 2021.3   

  • Steering committee member   Domestic

    2019.4 - 2021.3   

  • Steering committee member   Domestic

    2019.4 - 2021.3   

  • 日本歯周病学会   研究委員   Domestic

    2019.4 - 2021.3   

  • 日本歯周病学会   ペリオドンタルメディシン委員   Domestic

    2019.4 - 2021.3   

  • 日本歯周病学会   国際交流委員   Domestic

    2019.4 - 2021.3   

  • Steering committee member   Domestic

    2017.4 - 2019.3   

  • Steering committee member   Domestic

    2017.4 - 2019.3   

  • Steering committee member   Domestic

    2017.4 - 2019.3   

  • 日本歯周病学会   選挙管理委員   Domestic

    2017.4 - 2019.3   

  • 日本歯周病学会   研究委員   Domestic

    2017.4 - 2019.3   

  • 日本歯周病学会   国際交流委員   Domestic

    2017.4 - 2019.3   

  • Councilor   Domestic

    2016.4 - 2029.3   

  • 日本歯科保存学会   編集連絡委員   Domestic

    2015.4 - 2016.5   

  • 日本歯周病学会   編集連絡委員   Domestic

    2015.4 - 2016.5   

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Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

  • 準備委員長 International contribution

    ( 九州大学医学部百年講堂 ) 2021.10

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • 準備委員長

    日本歯周病学会第1回佐賀地区臨床研修会  ( 佐賀県歯科医師会館 ) 2019.2

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    Type:Competition, symposium, etc. 

    Number of participants:50

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • 座長

    日本歯周病学会 若手研究者の集い  ( 東京都新宿区 ) 2018.5

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • 準備委員長

    第60回日本歯周病学会春季学術大会  ( 福岡国際会議場 ) 2017.5

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    Type:Competition, symposium, etc. 

    Number of participants:2,800

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • シンポジスト International contribution

    ( 福岡国際会議場 ) 2015.10

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    Type:Competition, symposium, etc. 

  • 日本歯科保存学会会誌

    2015.4 - 2026.3

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    Type:Academic society, research group, etc. 

  • 日本歯周病学会会誌

    2015.4 - 2026.3

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    Type:Academic society, research group, etc. 

  • シンポジスト International contribution

    Kyudai Oral Bioscience 2013 —7th International Symposium —  2013.3

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    Type:Competition, symposium, etc. 

  • メイン会場責任者

    第52回秋季日本歯周病学会学術大会  ( 宮崎観光ホテル 宮崎市 ) 2009.10

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    Type:Competition, symposium, etc. 

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Research Projects

  • Spatial transcriptome analysis of GMSC-derived exoxme mediated peridontal tissue regneration

    Grant number:24K02623  2024.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Grant type:Scientific research funding

    CiNii Research

  • Challenge to periodontal tissue regeneration and refractory immune diseases based on amelogenin-CRP78 complex

    Grant number:23K27774  2024 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • 歯肉幹細胞由来エクソソームによる新規歯周病治療の開発

    2024 - 2025

    【シーズA310】令和6年度AMED橋渡し研究プログラム シーズA研究開発費

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    Authorship:Coinvestigator(s)  Grant type:On-campus funds, funds, etc.

  • アメロジェニン・CRP78複合体を基軸とした歯周組織再生と難治性免疫疾患への挑戦

    Grant number:23H03084  2023

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • NSKナカニシ財団2023年度研究開発助成

    2023

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    Grant type:Donation

  • 令和5年第12回小林財団研究助成

    2023

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    Grant type:Donation

  • Sprouty2 による上皮間葉転換制御を介した扁平上皮癌転移抑制機構の解明

    Grant number:20K10173  2020.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    武富 孝治, 讃井 彰一, 福田 隆男

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    Grant type:Scientific research funding

    近年、癌の分子標的薬の発展は目覚ましく、細胞表層の受容体に対するモノクローナル抗体や MEK 阻害剤に代表されるような細胞内の分子をターゲットとした分子標的薬も次々と開発されている。本研究では、細胞のチロシンキナーゼ型受容体の下流で細胞内シグナル伝達を制御する Sprouty2 に着目し、口腔扁平上皮癌細胞の上皮間葉転換 (EMT) における Sprouty2 の作用を解析する。口腔扁平上皮癌のリンパ行性転移機構において Sprouty2 が E-cadherin などの細胞接着分子の発現変化や、浸潤性発育にどのような影響を与えるかを in vitro の実験で調べる。

    CiNii Research

  • New therapeutic strategy for periodontal disease targeting exosomal miRNA derived from GMSCs.

    Grant number:20H03865  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant type:Scientific research funding

    CiNii Research

  • 歯肉幹細胞由来エクソソームmicroRNAを標的とした次世代歯周病治療の構築

    2020 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • The development of periodontal and endodontal tissue regenetation targeted amelogenin/GRP78 complex

    Grant number:20K09958  2020 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • Sprouty2 による上皮間葉転換制御を介した扁平上皮癌転移抑制機構の解明

    2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アメロジェニン・GRP78複合体を標的とした歯周歯髄組織再生技術の創生

    2017.4 - 2022.3

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    Authorship:Principal investigator 

  • 歯肉幹細胞由来エクソソームを用いた新規歯周病治療の開発

    2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • チロシンキナーゼ阻害分子Sproutyによる口腔癌リンパ節転移制御機構の解明

    2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 炎症の収束と組織リモデリングを誘導する次世代歯周組織再生治療法の構築

    Grant number:17K11986  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 財団法人武田科学振興財団 2017年度医学系研究奨励金

    2017

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    Grant type:Donation

  • 歯周医学の新展開~歯周炎症とエネルギー代謝の連関

    2016 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • M2マクロファージ転換技術を応用した新規歯周組織再生療法の開発

    Grant number:26463136  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • FGF抑制因子Sprouty /Spred によるエナメル上皮腫増殖制御機構の解明

    2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 新規アメロジェニン会合蛋白の分子基盤構築による歯周組織再生の創薬標的分子の同定

    2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 歯髄細胞由来TNF誘導因子(DPTIF)受容体の探索研究

    2014 - 2016

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 平成26年度 学術研究振興基金助成金/FGF抑制因子Sprouty/Spred によるエナメル上皮腫増殖制御機構の解明

    2014

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    Grant type:Donation

  • bFGFシグナル伝達のアンタゴニストを標的とした歯周組織再生治療薬の創薬

    Grant number:24792334  2012 - 2013

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • PGRP-Sによる粘膜免疫制御機構の解明

    2011

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    Grant type:Donation

  • Sproutyを分子標的薬とした歯周組織再生療法の発明

    Grant number:22792092  2010 - 2011

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新規アメロジェニン会合分子を標的とした歯周組織再生療法の発明

    2009.4 - 2012.3

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    Authorship:Coinvestigator(s) 

  • 財団法人武田科学振興財団 2009年度医学系研究奨励金

    2009

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    Grant type:Donation

  • 塩基性線維芽細胞成長因子(bFGF)シグナルのアンタゴニストを標的とした歯周組織再生療法の開発

    2009

    平成21年度九州大学教育研究プログラム・研究拠点形成 プロジェクト

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 増殖シグナル制御分子Sproutyを標的とした歯周組織再生療法の開発

    2008.4 - 2012.3

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    Authorship:Principal investigator 

  • 増殖シグナル制御分子Sproutyを標的とした歯周組織再生療法の開発

    Grant number:20890161  2008 - 2009

    科学研究費助成事業  若手研究(スタートアップ)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 歯周疾患における細胞骨格関連分子を標的とした免疫応答制御法の開発

    Grant number:17・5886  2005 - 2007

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • チロシンキナーゼ阻害分子 Sprouty による口腔癌リンパ節転移制御機構の解明

    Grant number:17K11692 

    武富 孝治, 讃井 彰一, 福田 隆男

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    Grant type:Scientific research funding

    Sproutyファミリーは EGF や TGF-βによる刺激よりも FGF により発現誘導されるが、その機能はチロシンキナーゼ型受容体下流のシグナル伝達機構の制御のみならず、上皮間葉転換と深く関わりのある TGF-βシグナル伝達機構における Smad1/5/8 のリン酸化も抑制することが示され、上皮間葉転換を負に制御する可能性を見いだすことができた。また、Raft においてMAPキナーゼ経路のみで作用する Caveolin との結合は、Spry ドメインのシステイン rich な領域が関与しており、TGF-βシグナルの抑制は Caveolin 非依存的に作用することが示唆された。

    CiNii Research

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Class subject

  • 歯周病学Ⅰ

    2023.10 - 2024.3   Second semester

  • 臨床実習

    2023.4 - 2024.3   Full year

  • 臨床予備実習

    2023.4 - 2023.9   First semester

  • 歯周病学Ⅱ

    2023.4 - 2023.9   First semester

  • 歯周病学Ⅰ

    2022.10 - 2023.3   Second semester

  • 臨床実習

    2022.4 - 2023.3   Full year

  • 臨床予備実習

    2022.4 - 2022.9   First semester

  • 歯周病学Ⅱ

    2022.4 - 2022.9   First semester

  • 歯周病学Ⅰ

    2021.10 - 2022.3   Second semester

  • 臨床実習

    2021.4 - 2022.3   Full year

  • 臨床予備実習

    2021.4 - 2021.9   First semester

  • 歯周病学Ⅱ

    2021.4 - 2021.9   First semester

  • 歯周病学Ⅰ

    2020.10 - 2021.3   Second semester

  • 臨床実習

    2020.4 - 2021.3   Full year

  • 臨床予備実習

    2020.4 - 2020.9   First semester

  • 歯周病学Ⅱ

    2020.4 - 2020.9   First semester

  • 歯周病学Ⅰ

    2019.10 - 2020.3   Second semester

  • 臨床実習

    2019.4 - 2020.3   Full year

  • 歯周病学Ⅱ

    2019.4 - 2019.9   First semester

  • 臨床予備実習

    2019.4 - 2019.9   First semester

  • 歯周病学Ⅰ

    2018.10 - 2019.3   Second semester

  • 臨床実習

    2018.4 - 2019.3   Full year

  • 臨床予備実習

    2018.4 - 2018.9   First semester

  • 歯周病学Ⅱ

    2018.4 - 2018.9   First semester

  • 歯周病学Ⅰ

    2017.10 - 2018.3   Second semester

  • 臨床実習

    2017.4 - 2018.3   Full year

  • 臨床予備見学・シミュレーション実習

    2017.4 - 2017.9   First semester

  • 臨床予備実習

    2017.4 - 2017.9   First semester

  • 総合歯科学

    2016.10 - 2017.3   Second semester

  • 基幹教育科目 課題協学A

    2016.10 - 2017.3   Second semester

  • 学生臨床実習

    2016.4 - 2016.9   First semester

  • 臨床予備見学・シミュレーション実習

    2016.4 - 2016.9   First semester

  • 臨床予備実習

    2016.4 - 2016.9   First semester

  • 歯周病学Ⅱ

    2016.4 - 2016.9   First semester

  • 総合歯科学

    2015.10 - 2016.3   Second semester

  • 歯周病学Ⅰ

    2015.10 - 2016.3   Second semester

  • 臨床予備実習

    2015.4 - 2015.9   First semester

  • 学生基礎実習(歯周病学Ⅱ)

    2015.4 - 2015.9   First semester

  • 学生臨床実習

    2015.4 - 2015.9   First semester

  • 歯科総論Ⅲ

    2015.4 - 2015.9   First semester

  • 臨床予備見学・シミュレーション実習

    2015.4 - 2015.9   First semester

  • 歯周病学Ⅰ

    2014.10 - 2015.3   Second semester

  • 臨床予備見学・シミュレーション実習

    2014.4 - 2014.9   First semester

  • 学生臨床実習

    2014.4 - 2014.9   First semester

  • 学生基礎実習

    2014.4 - 2014.9   First semester

  • 歯科総論Ⅲ

    2014.4 - 2014.9   First semester

  • 歯周病学Ⅰ

    2013.10 - 2014.3   Second semester

  • 学生臨床実習

    2013.4 - 2013.9   First semester

  • 歯科総論Ⅲ

    2013.4 - 2013.9   First semester

  • 学生基礎実習

    2013.4 - 2013.9   First semester

  • PBLチュートリアル

    2012.10 - 2013.3   Second semester

  • 学生臨床実習

    2012.4 - 2012.9   First semester

  • 学生基礎実習

    2012.4 - 2012.9   First semester

  • 歯学総論Ⅲ

    2012.4 - 2012.9   First semester

  • 歯学総論Ⅲ

    2011.10 - 2012.3   Second semester

  • 学生臨床実習

    2011.4 - 2011.9   First semester

  • 学生基礎実習

    2011.4 - 2011.9   First semester

  • 学生臨床実習

    2010.4 - 2010.9   First semester

  • 学生基礎実習

    2010.4 - 2010.9   First semester

  • 学生臨床実習

    2009.10 - 2010.3   Second semester

  • 学生基礎実習

    2009.10 - 2010.3   Second semester

▼display all

FD Participation

  • 2023.8   Role:Participation   Title:令和5年度4部局合同男女共同参画FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2023.6   Role:Participation   Title:R6年度科研費獲得セミナー~科研費制度及び研究計画書の書き方~

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.6   Role:Participation   Title:科研費申請書ー採択に近づく書き方のコツ

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role:Participation   Title:2022年度CPXの概要と昨年度からの変更点について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.6   Role:Participation   Title:ジャーナルをめぐる現状と論文の投稿・入手について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2020.4   Role:Participation   Title:CBT問題の作問における注意点ー採択される CBT問題を作成する上でのヒントー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.9   Role:Participation   Title:科研費申請のススメ!〜科学研究費補助金制度と研究計画調書作成時の注意点〜

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2019.3   Role:Participation   Title:2019年度臨床実地試験トライアル説明会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.8   Role:Participation   Title:歯学研究院の研究力分析と研究力強化に向けたScopus/Scival/Pure活用例 BIツールを用いた研究力分析の紹介

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.5   Role:Participation   Title:臨床実習御臨床能力試験トライアルの実施に向けて

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2018.3   Role:Participation   Title:東京医科歯科大学における国家試験対策の実践

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2017.11   Role:Participation   Title:ARO次世代医療センターの活用方法

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.12   Role:Participation   Title:歯学教育の現状と課題/反グローバル化と国際交流

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.6   Role:Participation   Title:国立大学改革プランへの対応・東京医科歯科大学歯学部改革への取り組み

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.5   Role:Participation   Title:CBT問題作成ワークショップ

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2016.2   Role:Participation   Title:H28年度課題協学科目FD

    Organizer:University-wide

  • 2015.12   Role:Participation   Title:医学教育改革の動向と歯学研究改革/歯学教育認証評価の必要性

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.9   Role:Participation   Title:平成27年度歯学研究院第一回FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.3   Role:Participation   Title:Comparisions between US and European Dental Schools - finances, research and clinical experience

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2015.2   Role:Participation   Title:誤飲・誤嚥のセミナー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.10   Role:Participation   Title:プロフェッショナリズム教育ー特に卒前教育について、授業を紹介しながらー

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2014.9   Role:Participation   Title:科研費獲得のポイント

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2013.10   Role:Participation   Title:PBLとチューターの役割―昭和大学の学部連携PBLの紹介―

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.9   Role:Participation   Title:アクティブラーニング とPBLテュートリアル教育

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.9   Role:Participation   Title:PBLチュートリアルにおけるチューター(ファシリテータ)の役割

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2012.1   Role:Participation   Title:日本人歯科医師の海外における活動 ―現状と可能性―

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.9   Role:Participation   Title:PBLチュートリアル教育 チューター講習会

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.9   Role:Participation   Title:東日本大震災 歯科医療従事者派遣活動報告

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.8   Role:Participation   Title:九州大学歯学研究院 FD「カリキュラムプランニングワークショップ」

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:昭和大学におけるPBL-チュートリアルの取り組み

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:歯学教育を取り巻く環境変化と求められる対応 =歯学教育の改善・充実に関する調査研究協力者会議を中心に=

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2011.1   Role:Participation   Title:歯科保健医療対策の動向

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.12   Role:Participation   Title:カリキュラムプランニングの基礎 ―目標・方略・評価―

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.12   Role:Participation   Title:学び方を学ぶPBLチュートリアル―高知大学での実践にもとづいて

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2010.3   Role:Participation   Title:QUEST-MAP次期中期目標・計画

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.12   Role:Participation   Title:演題:化学物質の安全管理対策

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.9   Role:Participation   Title:歯学研究院QUEST-MAPの最終案について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.8   Role:Participation   Title:歯学研究院QUEST-MAPの最終案について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.7   Role:Participation   Title:ニューカッスル大学歯学部を事例とした英国の歯学教育制度の紹介

    Organizer:[Undergraduate school/graduate school/graduate faculty]

  • 2009.4   Role:Participation   Title:歯学研究院のQUEST-MAP(最終版)について

    Organizer:[Undergraduate school/graduate school/graduate faculty]

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2017  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2016  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2015  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2014  釜山大学歯学部  Classification:Faculty conurrently holding another post  Domestic/International Classification:Japan 

  • 2014  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2013  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2013  釜山大学歯学部  Classification:Faculty conurrently holding another post  Domestic/International Classification:Japan 

  • 2012  博多メディカル専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2010  釜山大学歯学部  Domestic/International Classification:Japan 

  • 2009  福岡医科歯科技術専門学校・歯科衛生士科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2008  香港大学歯学部  Domestic/International Classification:Japan 

  • 2008  釜山大学歯学部  Domestic/International Classification:Japan 

▼display all

Other educational activity and Special note

  • 2023  Special Affairs 

  • 2022  Special Affairs 

  • 2021  Special Affairs 

  • 2021  Special Affairs 

  • 2021  Special Affairs 

  • 2020  Special Affairs 

  • 2019  Special Affairs 

  • 2018  Special Affairs 

  • 2017  Special Affairs 

  • 2017  Special Affairs 

  • 2016  Special Affairs 

  • 2016  Special Affairs 

  • 2015  Special Affairs 

  • 2015  Special Affairs 

  • 2014  Special Affairs 

  • 2014  Special Affairs 

  • 2013  Special Affairs 

  • 2013  Special Affairs 

  • 2013  Special Affairs 

  • 2012  Special Affairs 

  • 2012  Special Affairs 

  • 2011  Special Affairs 

  • 2011  Special Affairs 

  • 2011  Special Affairs 

  • 2011  Special Affairs 

  • 2010  Special Affairs 

  • 2010  Special Affairs 

  • 2009  Special Affairs 

  • 2009  Special Affairs 

  • 2009  Special Affairs 

  • 2008  Special Affairs 

  • 2008  Special Affairs 

▼display all

Outline of Social Contribution and International Cooperation activities

  • JICA口腔健康科学教育 
    海外研修生外来見学指導
    九州大学病院国際化担当医師

Social Activities

  • 歯周組織再生治療 エムドゲイン VS リグロス

    熊本歯周病勉強会  熊本県歯科医師会会館  2019.2

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 開業医は歯周組織再生剤「リグロス🄬」を導入すべきか?

    歯誠会  福岡県歯科医師会会館  2018.7

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 第9回歯科臨床セミナー:長寿社会における地域歯科医療の貢献

    九州大学病院歯科部門・九州大学歯学会  福岡県歯科医師会会館  2017.3

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • もっと知りたいペリオ-日々進化する医療を知ろう!-

    福岡県歯科衛生士会  福岡県歯科医師会会館  2016.12

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「九州大学病院の歯科治療紹介」「歯周病と全身疾患の関わり合い」

    主催:若宮ダイヤモンドクラブ 共催:若宮校区ねんりんクラブ  若宮公民館  2011.7

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 福岡市歯科医師会会報(10月号) 「Q&Aお答えします」 歯周組織の再生療法の現状について

    福岡市歯科医師会  2010.10

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

  • アメリカ合衆国における歯周治療の実際

    歯誠会  福岡県歯科医師会会館  2008.10

     More details

    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • これだけは知っておきたい歯周治療の基礎知識

    歯誠会  福岡県歯科医師会会館  2006.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

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Media Coverage

  • 「研究プロジェクトの精鋭たち/わが医局のエース」 Newspaper, magazine

    ザ・クインテッセンス  2011.5

     More details

    「研究プロジェクトの精鋭たち/わが医局のエース」

Educational Activities for Highly-Specialized Professionals in Other Countries

  • 2010.5   JICA

    Main countries of student/trainee affiliation:Chile

  • 2009.5   JICA

    Main countries of student/trainee affiliation:Chile

Travel Abroad

  • 2010.7

    Staying countory name 1:Austria   Staying institution name 1:Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA)

  • 2009.4

    Staying countory name 1:United States   Staying institution name 1:Mount Sinai, School of Medicine

  • 2006.6 - 2007.8

    Staying countory name 1:United States   Staying institution name 1:Indiana University

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Dentistry / Periodontal Dentistry

Clinician qualification

  • Specialist

    日本歯周病学会

  • Preceptor

    日本歯周病学会

  • Certifying physician

    日本歯科保存学会

Year of medical license acquisition

  • 1999

Notable Clinical Activities

  • ・海外からの患者受け入れ相談窓口となる国際医療連携担当医師 ・九州大学病院個人情報保護における歯周病科保護業務責任者 ・臨床研究認定歯科医師 ・高度先進医療センター百人部会委員 ・歯学部サマースクール外来見学説明担当教員