Updated on 2024/11/13

Information

 

写真a

 
FUJIMOTO NORIKO
 
Organization
Kyushu University Hospital Cardiovascular Surgery Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425557
Profile
診療業務 ・定例手術他緊急手術多数 ・術前術後管理 ・毎日の病棟回診、教室内カンファレンスによる症例検討 ・合同カンファレンスによる症例検討 ・再来患者診察 教育業務 ・学生実習指導
External link

Degree

  • Medical Doctor

Research Interests・Research Keywords

  • Research theme:Cardiovascular Surgery Congenital Heart Disease

    Keyword:Cardiovascular Surgery Congenital Heart Disease

    Research period: 2016.9

Papers

  • Acute Dapagliflozin Administration Ameliorates Cardiac Surgery-Associated Acute Kidney Injury in a Rabbit Model Reviewed International journal

    Matsuda Kensaku, Mitsuo Hiroshi, Nishijima Takuya, Uchiyama Hikaru, Nita Tobuhiro, Matsunaga Shogo, Fujimoto Noriko, Ushijima Tomoki, Ando Yusuke, Kan-o Meikun, Shinohara Gen, Kimura Satoshi, Sonoda Hiromichi, Shiose Akira

    Circulation Journal   88 ( 9 )   1488 - 1498   2024.8   ISSN:13469843 eISSN:13474820

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Circulation Society  

    <p><b><i>Background:</i></b>  Several studies have shown that sodium-glucose cotransporter-2 inhibitors have a renoprotective effect on acute kidney injury (AKI), but their effect on cardiac surgery-associated AKI is unknown.</p><p><b><i>Methods and Results:</i></b>  AKI was induced in 25 rabbits without diabetes mellitus by cardiopulmonary bypass (CPB) for 2 h and they were divided into 5 groups: sham; dapagliflozin-treated sham; CPB; dapagliflozin-treated CPB; and furosemide-treated CPB (n=5 in each group). Dapagliflozin was administered via the femoral vein before initiating CPB. Kidney tissue and urine and blood samples were collected after the surgical procedure. There were no differences in the hemodynamic variables of each group. Dapagliflozin reduced serum creatinine and blood urea nitrogen concentrations, and increased overall urine output (all P<0.05). Hematoxylin and eosin staining showed that the tubular injury score was improved after dapagliflozin administration (P<0.01). Dapagliflozin administration mitigated reactive oxygen species and kidney injury molecule-1 as assessed by immunohistochemistry (both P<0.0001). Protein expression analysis showed improvement of inflammatory cytokines and apoptosis, and antioxidant enzyme expression was elevated (all P<0.05) through activation of the nuclear factor erythroid 2-related factor 2 pathway (P<0.01) by dapagliflozin.</p><p><b><i>Conclusions:</i></b>  Acute intravenous administration of dapagliflozin protects against CPB-induced AKI. Dapagliflozin may have direct renoprotective effects in renal tubular cells.</p>

    DOI: 10.1253/circj.cj-23-0864

    PubMed

    CiNii Research

  • Acute Dapagliflozin Administration Ameliorates Cardiac Surgery-Associated Acute Kidney Injury in a Rabbit Model(タイトル和訳中) Reviewed

    Matsuda Kensaku, Mitsuo Hiroshi, Nishijima Takuya, Uchiyama Hikaru, Nita Tobuhiro, Matsunaga Shogo, Fujimoto Noriko, Ushijima Tomoki, Ando Yusuke, Kan-o Meikun, Shinohara Gen, Kimura Satoshi, Sonoda Hiromichi, Shiose Akira

    Circulation Journal   88 ( 9 )   1488 - 1498   2024.8   ISSN:1346-9843

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    Language:English   Publisher:(一社)日本循環器学会  

  • 高度漏斗胸を有する急性A型大動脈解離に対してL字切開アプローチによる弓部置換術を施行した1例 Reviewed

    藤本 智子, 土居 雄太, 橋野 朗, 梅末 正芳

    日本心臓血管外科学会雑誌   52 ( 2 )   123 - 127   2023.3   ISSN:0285-1474

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:(NPO)日本心臓血管外科学会  

    症例は65歳女性.以前より胸部大動脈瘤を指摘されていた.自宅で倒れているところを家人に発見され救急搬送された.搬送時の意識レベルはJCS200で左共同偏視と右半身完全麻痺を認めた.頭部CT検査にて左大脳半球に皮髄境界不明瞭の領域を認めた.造影CT検査にて大動脈基部から腹部大動脈末梢に至る広範な偽腔開存型の大動脈解離,右内頸動脈閉塞,左内頸動脈狭窄および高度漏斗胸を認めた.搬送後経時的な神経学的症状の改善を認め,搬送3時間後の頭部CT検査で新たな梗塞および出血所見を認めなかったため,緊急手術を行う方針とした.高度漏斗胸に伴い心臓および大血管は左胸腔内に位置しており,胸骨正中切開および左第5肋間開胸によるL字切開でアプローチした.右大腿および右腋窩動脈送血,右房脱血で人工心肺を確立し,中等度低体温循環停止,選択的脳灌流併用下に手術を施行した.腕頭動脈-左総頸動脈間の小彎側にentryを認めたため,左総頸動脈-左鎖骨下動脈間で大動脈を離断し,4分枝付き人工血管を用いて部分弓部置換術を行った.術後右不全麻痺が残存し,術後45日目にリハビリ病院へ転移となった.高度漏斗胸合併患者に対する開心術を行う際のアプローチ選択について一定のコンセンサスは存在しない.本症例のように救命を第一とした高度漏斗胸患者に対しL字切開アプローチを選択することは,良好な視野のもとに安全な手術を行う上で妥当な選択であると考える.(著者抄録)

  • Transgenic expression of the Formin protein Fhod3 selectively in the embryonic heart : Role of actin-binding activity of Fhod3 and its sarcomeric localization during myofibrillogenesi Reviewed International journal

    PLoS One   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

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Other educational activity and Special note

  • 2016  Special Affairs