Updated on 2024/11/21

Information

 

写真a

 
KISHIMOTO JUNJI
 
Organization
Kyushu University Hospital Center for Clinical and Translational Research Information Counter Associate Professor
School of Medicine Department of Medicine(Concurrent)
Title
Associate Professor
Contact information
メールアドレス
Tel
0926426730
Profile
Joint research in various area of medicine as a biostatistician. CAMIT committee member. Part-time lecturer of "Multivariate Analysis" and "SAS introduction" at The University of Tokyo. Chief statistician of clinical trials.
External link

Degree

  • Master of Arts in Behavioral Sciences

Research History

  • 1988-1999: SAS Institute Japan

    1988-1999: SAS Institute Japan

  • 1999-2002: 慶應義塾大学湘南藤沢キャンパス 専任講師 2003-2006: 東京大学医学系研究科 クリニカルバイオインフォマティクス 科学技術振興特任教員

Research Interests・Research Keywords

  • Research theme:QOLデータの多変量解析

    Keyword:QOL Multivariate-Analysis

    Research period: 2003.1 - 2006.10

  • Research theme:Data analysis of PTSD/DV

    Keyword:PTSD DV

    Research period: 1999.4 - 2006.3

Papers

  • Atezolizumab and Platinum Plus Pemetrexed With or Without Bevacizumab for Metastatic Nonsquamous Non-Small Cell Lung Cancer: A Phase 3 Randomized Clinical Trial. Reviewed International journal

    Shiraishi, Yoshimasa Kishimoto, Junji Sugawara, Shunichi Mizutani, Hideaki Daga, Haruko Azuma, Koichi Matsumoto, Hirotaka Hataji, Osamu Nishino, Kazumi Mori, Masahide Shukuya, Takehito Saito, Haruhiro Tachihara, Motoko Hayashi, Hidetoshi Tsuya, Asuka Wakuda, Kazushige Yanagitani, Noriko Sakamoto, Tomohiro Miura, Satoru Hata, Akito Okada, Morihito Kozuki, Toshiyuki Sato, Yuki Harada, Taishi Takayama, Koichi Yamamoto, Nobuyuki Nakagawa, Kazuhiko Okamoto, Isamu

    JAMA oncology   10 ( 3 )   315 - 324   2024.4   ISSN:2374-2437 eISSN:2374-2445

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    DOI: 10.1001/jamaoncol.2023.5258

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  • Assessment of Pediatric Admissions for Kawasaki Disease or Infectious Disease During the COVID-19 State of Emergency in Japan Invited Reviewed International journal

    Hara, T Furuno, K Yamamura, K Kishimoto, J Mizuno, Y Murata, K Onoyama, S Hatae, K Takemoto, M Ishizaki, Y Kanno, S Sato, K Motomura, Y Sakai, Y Ohga, S Yashiro, M Nakamura, Y Hara, T

    JAMA NETWORK OPEN   4 ( 4 )   2021.4

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    DOI: 10.1001/jamanetworkopen.2021.4475

  • Amlodipine versus angiotensin II receptor blocker; control of blood pressure evaluation trial in diabetics (ADVANCED-J) Reviewed

    Ryuzo Kawamori, Hiroyuki Daida, Yasushi Tanaka, Katsumi Miyauchi, Akira Kitagawa, Dobun Hayashi, Junji Kishimoto, Shunya Ikeda, Yutaka Imai, Tsutomu Yamazaki

    BMC Cardiovascular Disorders   6   2006.10

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    DOI: 10.1186/1471-2261-6-39

  • Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes Reviewed

    Tsuguharu Takahashi, Toru Ogasawara, Junji Kishimoto, Guangyao Liu, Hirotaka Asato, Takashi Nakatsuka, Eijyu Uchinuma, Kozo Nakamura, Hiroshi Kawaguchi, Tsuyoshi Takato, Kazuto Hoshi

    Cell Transplantation   14 ( 9 )   683 - 693   2005.12

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    DOI: 10.3727/000000005783982675

  • The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations Reviewed

    Keisuke Maruyama, Nobutaka Kawahara, Masahiro Shin, Masao Tago, Junji Kishimoto, Hiroki Kurita, Shunsuke Kawamoto, Akio Morita, Takaaki Kirino

    New England Journal of Medicine   352 ( 2 )   146 - 153   2005.1

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    DOI: 10.1056/NEJMoa040907

  • Reliability and validity of the Japanese-language version of the Impact of Event Scale-Revised (IES-R-J) Four studies of different traumatic events Reviewed

    Nozomu Asukai, Hiroshi Kato, Noriyuki Kawamura, Yoshiharu Kim, Kohei Yamamoto, Junji Kishimoto, Yuko Miyake, Aya Nishizono-Maher

    Journal of Nervous and Mental Disease   190 ( 3 )   175 - 182   2002.4

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    DOI: 10.1097/00005053-200203000-00006

  • Respiratory viral infections and Kawasaki disease: A molecular epidemiological analysis

    Marutani, K; Murata, K; Mizuno, Y; Onoyama, S; Hoshina, T; Yamamura, K; Furuno, K; Sakai, Y; Kishimoto, J; Kusuhura, K; Hara, T

    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION   57 ( 5 )   691 - 699   2024.10   ISSN:1684-1182 eISSN:1995-9133

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    Background/Purpose: Recent large-scale epidemiological studies have revealed significant temporal associations between certain viral infections and the subsequent development of Kawasaki disease (KD). Despite these associations, definitive laboratory evidence linking acute or recent viral infections to KD cases remains elusive. The objective of this study is to employ a molecular epidemiological approach to investigate the temporal association between viral infections and the development of KD. Methods: We analyzed 2460 patients who underwent the FilmArray® Respiratory Panel test between April 2020 and September 2021. Results: Following the application of inclusion criteria, 2402 patients were categorized into KD (n = 148), respiratory tract infection (n = 1524), and control groups (n = 730). The KD group exhibited higher positive rates for respiratory syncytial virus (RSV), human rhinovirus/enterovirus (hRV/EV), parainfluenza virus (PIV) 3, and adenovirus (AdV) compared to the control group. Additionally, coinfections involving two or more viruses were significantly more prevalent in the KD group. Notably, RSV-positive, hRV/EV-positive, and PIV3-positive KD patients exhibited a one-month delay in peak occurrence compared to non-KD patients positive for corresponding viruses. In contrast, AdV-positive KD cases did not show a one-month delay in peak occurrence. Moreover, anti-RSV, anti-PIV3, and anti-AdV antibody-positive rates or antibody titers were higher in RSV-, PIV3-, and AdV-positive KD cases, respectively, compared to non-KD cases with the same viral infections. Conclusion: Recent infection with RSV, PIV3, or AdV, occasionally in conjunction with other viruses, may contribute to the pathogenesis of KD as infrequent complications.

    DOI: 10.1016/j.jmii.2024.07.001

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  • Safety and efficacy of ripasudil eye drops in preterm infants with retinopathy of prematurity: phase 1/2, open label, single-arm trial

    Arima, M; Inoue, H; Misumi, A; Tsukamoto, S; Matsushita, I; Araki, S; Ohta, M; Takahashi, K; Imazato, M; Goto, T; Aoki, Y; Tagawa, K; Hirose, M; Fujita, Y; Yoshida, N; Nakao, S; Kondo, H; Kusuhara, K; Kimura, K; Hasegawa, S; Ikeda, Y; Kodama, Y; Moritake, H; Ochiai, M; Ohga, S; Kishimoto, J; Todaka, K; Ieiri, I; Sonoda, KH

    JAPANESE JOURNAL OF OPHTHALMOLOGY   68 ( 5 )   490 - 499   2024.9   ISSN:0021-5155 eISSN:1613-2246

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    Language:English   Publisher:Japanese Journal of Ophthalmology  

    Purpose: To assess the safety and efficacy of ripasudil for retinopathy of prematurity (ROP). Study design: Phase 1/2, multicenter, open-label, single-arm, 12-week clinical trial. Methods: Infants born with gestational age (GA) of ≤ 32 weeks or weight of ≤ 1500 g with zone I or II, ≥ stage 1, ROP in both eyes were enrolled. Ripasudil eye drops were administered to patients in both eyes. Phase 1 was a dose-escalation study (once daily for 1 week, then twice daily for 2 weeks); an additional dosing up to 9 weeks was allowed if no safety issues occurred. In phase 2, ripasudil was administered twice daily for up to 12 weeks. Adverse events were assessed. The proportion of patients with type 1 ROP progression, number of days for type 1 ROP progression, and progression to the most advanced ROP stage were estimated. Results: Twenty-four infants were enrolled (phase 1, n = 3; phase 2, n = 21). Nineteen and four patients experienced systemic and ocular adverse events, respectively. Efficacy endpoints were not different between the ripasudil and historical control groups. However, in the GA ≤ 27 weeks subgroup, fewer patients progressed to type 1 ROP in the ripasudil than in the historical control group (P = 0.09). In the GA ≤ 27 weeks subgroups, the 25th percentile for the number of days for type 1 ROP progression was 22 days in the historical control group and 44 days in the ripasudil group. Conclusion: Ripasudil was safe and inhibited/delayed type 1 ROP progression, especially in infants with short GA.

    DOI: 10.1007/s10384-024-01100-3

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  • Changing trends in traumatic spinal cord injury in an aging society: Epidemiology of 1152 cases over 15 years from a single center in Japan

    Yokota, K; Sakai, H; Kawano, O; Morishita, Y; Masuda, M; Hayashi, T; Kubota, K; Ideta, R; Ariji, Y; Koga, R; Murai, S; Ifuku, R; Uemura, M; Kishimoto, J; Watanabe, H; Nakashima, Y; Maeda, T

    PLOS ONE   19 ( 5 )   e0298836   2024.5   ISSN:1932-6203

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    Traumatic spinal cord injury (TSCI) causes an insult to the central nervous system, often resulting in devastating temporary or permanent neurological impairment and disability, which places a substantial financial burden on the health-care system. This study aimed to clarify the up-to-date epidemiology and demographics of patients with TSCI treated at the largest SCI center in Japan. Data on all patients admitted to the Spinal Injuries Center with TSCI between May 2005 and December 2021 were prospectively collected using a customized, locally designed SCI database named the Japan Single Center Study for Spinal Cord Injury Database (JSSCI-DB). A total of 1152 patients were identified from the database. The study period was divided into the four- or five-year periods of 2005–2009, 2010–2013, 2014–2017, and 2018–2021 to facilitate the observation of general trends over time. Our results revealed a statistically significant increasing trend in age at injury. Since 2014, the average age of injury has increased to exceed 60 years. The most frequent spinal level affected by the injury was high cervical (C1-C4: 45.8%), followed by low cervical (C5-C8: 26.4%). Incomplete tetraplegia was the most common cause or etiology category of TSCI, accounting for 48.4% of cases. As the number of injuries among the elderly has increased, the injury mechanisms have shifted from high-fall trauma and traffic accidents to falls on level surfaces and downstairs. Incomplete tetraplegia in the elderly due to upper cervical TSCI has also increased over time. The percentage of injured patients with an etiology linked to alcohol use ranged from 13.2% (2005–2008) to 19% (2014–2017). Given that Japan has one of the highest aging populations in the world, epidemiological studies in this country will be very helpful in determining health insurance and medical costs and deciding strategies for the prevention and treatment of TSCI in future aging populations worldwide.

    DOI: 10.1371/journal.pone.0298836

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  • 進行性ホルモン感受性前立腺癌に対するGnRHアンタゴニスト単独療法とGnRHアゴニスト+ビカルタミド併用療法 KYUCOG-1401試験(GnRH antagonist monotherapy versus a GnRH agonist plus bicalutamide for advanced hormone-sensitive prostate cancer: KYUCOG-1401)

    Yokomizo Akira, Shiota Masaki, Morokuma Futoshi, Eto Masatoshi, Matsuyama Hideyasu, Matsumoto Hiroaki, Kamoto Toshiyuki, Terada Naoki, Kawahara Kazuya, Enokida Hideki, Tatarano Shuichi, Fujimoto Naohiro, Higashijima Katsuyoshi, Sakai Hideki, Hakariya Tomoaki, Igawa Tsukasa, Suekane Shigetaka, Kamba Tomomi, Sugiyama Yutaka, Kishimoto Junji, Naito Seiji

    International Journal of Urology   31 ( 4 )   362 - 369   2024.4   ISSN:0919-8172

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    進行性ホルモン感受性前立腺癌(HSPC)に対するゴナドトロピン放出ホルモン(GnRH)アンタゴニスト単独療法と、GnRHアゴニストとビカルタミド併用による複合アンドロゲン遮断療法(CAB)の有効性と安全性を、無作為化非盲検多施設共同試験(KYUCOG-1401試験)で比較した。患者200例を登録し、A群(GnRHアンタゴニスト単独療法後にビカルタミドを追加)またはB群(GnRHアゴニストとビカルタミド併用によるCAB)に無作為化した。A群100例、B群98例を解析した。主要評価項目の前立腺特異抗原(PSA)無増悪生存期間(PFS)はB群で有意に長かった(ハザード比:1.40、95%CI:1.01~1.95、p=0.041)。副次評価項目のCAB治療不成功までの期間はA群の方がわずかに長かった(ハザード比:0.80、95%CI:0.59~1.08、p=0.146)。X線画像上のPFSおよび全生存期間に有意な群間差は認められなかった。60週時に血清テストステロン値が去勢レベルに達しなかった患者の割合はA群の方が高かった(p=0.046)。血清骨代謝マーカー値や脂質マーカー値に有意な群間差はなかった。注射部位反応の発生率はA群の方が高かった。以上より、進行性HSPCに対するGnRHアゴニストとビカルタミドを併用したCABは、GnRHアンタゴニスト単独療法よりも有効な治療法である可能性が示唆された。

  • Development of deep-learning models for real-time anaerobic threshold and peak VO2 prediction during cardiopulmonary exercise testing Reviewed International journal

    Watanabe, Tatsuya Tohyama, Takeshi Ikeda, Masataka Fujino, Takeo Hashimoto, Toru Matsushima, Shouji Kishimoto, Junji Todaka, Koji Kinugawa, Shintaro Tsutsui, Hiroyuki Ide, Tomomi

    EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY   31 ( 4 )   448 - 457   2024.3   ISSN:2047-4873 eISSN:2047-4881

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    DOI: 10.1093/eurjpc/zwad375

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  • Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population Reviewed International journal

    Ikeda, Shota Shinohara, Keisuke Tagawa, Koshiro Tohyama, Takeshi Kishimoto, Junji Kazurayama, Masaya Tanaka, Shinji Yamaizumi, Masamitsu Nagayoshi, Hirokazu Toyama, Kensuke Matsushima, Shouji Tsutsui, Hiroyuki Kinugawa, Shintaro

    SCIENTIFIC REPORTS   14 ( 1 )   301   2024.1   ISSN:2045-2322

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    DOI: 10.1038/s41598-023-51085-1

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  • CD14 down-modulation as a real-time biomarker in Kawasaki disease Reviewed International journal

    Inada, Yutaro Sonoda, Motoshi Mizuno, Yumi Yamamura, Kenichiro Motomura, Yoshitomo Takuma, Aoba Murata, Kenji Furuno, Kenji Tezuka, Junichiro Sakai, Yasunari Ohga, Shouichi Kishimoto, Junji Hosaka, Koki Sakata, Satomi Hara, Toshiro

    CLINICAL & TRANSLATIONAL IMMUNOLOGY   13 ( 1 )   e1482   2024.1   ISSN:2050-0068 eISSN:2050-0068

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    DOI: 10.1002/cti2.1482

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  • A Multicenter, Randomized, Warfarin-Controlled Trial of Edoxaban in Patients With Chronic Thromboembolic Pulmonary Hypertension: KABUKI Trial

    Hosokawa, K; Kishimoto, J; Taniguchi, Y; Ikeda, N; Inami, T; Yasuda, S; Murohara, T; Hatano, M; Tamura, Y; Yamashita, J; Tatsumi, K; Tsujino, I; Kobayakawa, Y; Adachi, S; Yaoita, N; Minatsuki, S; Todaka, K; Fukuda, K; Tsutsui, H; Abe, K

    CIRCULATION   148 ( 25 )   E309 - E309   2023.12   ISSN:0009-7322 eISSN:1524-4539

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  • GnRH antagonist monotherapy versus a GnRH agonist plus bicalutamide for advanced hormone-sensitive prostate cancer; KYUCOG-1401 Reviewed International journal

    Yokomizo, Akira Shiota, Masaki Morokuma, Futoshi Eto, Masatoshi Matsuyama, Hideyasu Matsumoto, Hiroaki Kamoto, Toshiyuki Terada, Naoki Kawahara, Kazuya Enokida, Hideki Tatarano, Shuichi Fujimoto, Naohiro Higasijima, Katsuyoshi Sakai, Hideki Hakariya, Tomoaki Igawa, Tsukasa Suekane, Shigetaka Kamba, Tomomi Sugiyama, Yutaka Kishimoto, Junji Naito, Seiji

    INTERNATIONAL JOURNAL OF UROLOGY   31 ( 4 )   362 - 369   2023.12   ISSN:0919-8172 eISSN:1442-2042

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    DOI: 10.1111/iju.15371

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  • スタチンおよびエゼチミブによる脂質低下療法中の血清オキシステロールと冠動脈プラーク退縮との関連性 CuVIC試験からの知見(Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial)

    Nakano Yasuhiro, Yamamoto Mitsutaka, Matoba Tetsuya, Katsuki Shunsuke, Nakashiro Soichi, Takase Susumu, Akiyama Yusuke, Nagata Takuya, Mukai Yasushi, Inoue Shujiro, Oi Keiji, Higo Taiki, Takemoto Masao, Suematsu Nobuhiro, Eshima Kenichi, Miyata Kenji, Usui Makoto, Sadamatsu Kenji, Kadokami Toshiaki, Hironaga Kiyoshi, Ichi Ikuyo, Todaka Koji, Kishimoto Junji, Tsutsui Hiroyuki

    Journal of Atherosclerosis and Thrombosis   30 ( 8 )   907 - 918   2023.8   ISSN:1340-3478

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    冠動脈ステント留置術を受けた冠動脈疾患の患者をスタチン(S)またはSとエゼチミブの併用(S+E)で治療するCuVIC試験から、治療前と6~8ヵ月追跡調査後の非責任病変の血管内超音波(IVUS)画像が得られた79症例(S群39名、S+E群40名)を抽出し解析した。治療期間後のS+E群のLDL-コレステロール(LDL-C)値はS群と比べて有意に低かった。S+E群ではコレステロール吸収のマーカーであるcampesterol、オキシステロール(β-epoxycholesterol、4β-hydroxycholesterol、27-hydroxycholesterol)も低かった。IVUS解析でS+E群のプラーク退縮率はS群と比べて大きかった。campesterolおよび27-hydroxycholesterolの低下はプラーク退縮と正相関し、LDL-Cの低下は相関しなかった。

  • Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial Reviewed International journal

    Esaki, Mitsuru Ihara, Eikichi Manabe, Noriaki Kawami, Noriyuki Iwakiri, Katsuhiko Akiyama, Junichi Kuribayashi, Shiko Uraoka, Toshio Ogino, Haruei Chinen, Takatoshi Misumi, Akiko Watanabe, Hiroko Suzuki, Maya Kishimoto, Junji Ogawa, Yoshihiro

    TRIALS   24 ( 1 )   459   2023.7   eISSN:1745-6215

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    DOI: 10.1186/s13063-023-07468-w

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  • Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis Reviewed International journal

    Akiyama, Yusuke Katsuki, Shunsuke Matoba, Tetsuya Nakano, Yasuhiro Takase, Susumu Nakashiro, Soichi Yamamoto, Mitsutaka Mukai, Yasushi Inoue, Shujiro Oi, Keiji Higo, Taiki Takemoto, Masao Suematsu, Nobuhiro Eshima, Kenichi Miyata, Kenji Usui, Makoto Sadamatsu, Kenji Kadokami, Toshiaki Hironaga, Kiyoshi Ichi, Ikuyo Todaka, Koji Kishimoto, Junji Tsutsui, Hiroyuki

    NUTRIENTS   15 ( 13 )   2023.7   eISSN:2072-6643

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    DOI: 10.3390/nu15132997

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  • 【アジアにおける高血圧症管理に関する現在のエビデンスと展望】心血管疾患の既往がない2型糖尿病患者において安静時心拍数高値は心血管イベントリスクと関連する(【Current evidence and perspectives for hypertension management in Asia】A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease)

    Ikeda Shota, Shinohara Keisuke, Enzan Nobuyuki, Matsushima Shouji, Tohyama Takeshi, Funakoshi Kouta, Kishimoto Junji, Itoh Hiroshi, Komuro Issei, Tsutsui Hiroyuki

    Hypertension Research   46 ( 5 )   1090 - 1099   2023.5   ISSN:0916-9636

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    安静時心拍数(RHR)と心血管イベント(心、脳、腎血管疾患または関連死)の関連について検討した。EMPATHY(The standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY)試験に参加した網膜症合併2型糖尿病患者4746名を、ベースライン時のRHR(中央値76、四分位範囲69~85bpm)で4群に分け、心血管イベントの発生率を比較した。RHR高値群ほど低年齢であり、BMI、血圧、HbA1c、eGFR、喫煙率、糖尿病合併症の有病率が高かった。Cox比例ハザードモデルによる解析の結果、RHR高値は心血管イベントと有意に関連し、RHR 60~69bpm群に対する70~79bpm群および≧80bpm群の多変量調整ハザード比は、それぞれ1.50(95%CI 1.03~2.20)および1.62(1.11~2.36)であった(P<0.05)。心血管イベントリスクはRHRが70bpm以上であれば同様に高い傾向にあり、両者間に線形関係はみられなかった。

  • A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease

    Ikeda, S; Shinohara, K; Enzan, N; Matsushima, S; Tohyama, T; Funakoshi, K; Kishimoto, J; Itoh, H; Komuro, I; Tsutsui, H

    HYPERTENSION RESEARCH   46 ( 5 )   1090 - 1099   2023.5   ISSN:0916-9636 eISSN:1348-4214

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    A higher resting heart rate (RHR) is associated with an increased risk of cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and cardiovascular diseases. The aim of this study was to investigate the association between RHR and cardiovascular events in T2DM patients with diabetic retinopathy and without known cardiovascular disease. We analyzed the association between RHR and cardiovascular events, including coronary, cerebral, renal and vascular events or cardiovascular death in T2DM patients with retinopathy and hyperlipidemia without prior cardiovascular events who were enrolled in the EMPATHY study. Data from 4746 patients were analyzed. The median RHR was 76 bpm. Patients were divided into four groups based on their baseline RHR (< 60, 60–69, 70–79, and ≥80 bpm). Patients with a higher RHR were more likely to be younger and had a higher body mass index, blood pressure value, HbA1c value, and estimated glomerular filtration rate and a lower B-type natriuretic peptide value; they also had a higher proportion of current smoking status, neuropathy, and nephropathy. After adjusting for confounders, including the aforementioned risk factors, a RHR of 70–79 bpm and a RHR ≥ 80 bpm were significantly associated with cardiovascular events (hazard ratio 1.50, 95% CI 1.03–2.20; and hazard ratio 1.62, 95% CI 1.11–2.36; respectively) compared to a RHR of 60–69 bpm. The analysis using restricted cubic splines indicated that the cardiovascular risk seemed to be similarly high when the RHR range was ≥70 bpm. In conclusion, in T2DM patients with diabetic retinopathy and without known cardiovascular disease, a high RHR, particularly ≥70 bpm, was associated with the risk of cardiovascular events compared to a RHR of 60–69 bpm. [Figure not available: see fulltext.].

    DOI: 10.1038/s41440-023-01178-1

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  • 引きこもり者の家族に対する3日間の介入プログラムの開発(Development of a 3-Day Intervention Program for Family Members of Hikikomori Sufferers)

    Kubo Hiroaki, Urata Hiromi, Sakai Motohiro, Nonaka Shunsuke, Kishimoto Junji, Saito Kazuhiko, Tateno Masaru, Kobara Keiji, Fujisawa Daisuke, Hashimoto Naoki, Suzuki Yuriko, Honda Yoko, Otsuka Kotaro, Kanba Shigenobu, Kuroki Toshihide, Kato Takahiro A.

    Japanese Psychological Research   65 ( 2 )   190 - 199   2023.4   ISSN:0021-5368

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  • Deep Learning of ECG for the Prediction of Postoperative Atrial Fibrillation Reviewed International journal

    Tohyama, Takeshi; Ide, Tomomi; Ikeda, Masataka; Nagata, Takuya; Tagawa, Koshiro; Hirose, Masayuki; Funakoshi, Kouta; Sakamoto, Kazuo; Kishimoto, Junji; Todaka, Koji; Nakashima, Naoki; Tsutsui, Hiroyuki

    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY   16 ( 2 )   110 - 112   2023.2   ISSN:1941-3149 eISSN:1941-3084

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  • A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease Reviewed International journal

    Ikeda, Shota; Shinohara, Keisuke; Enzan, Nobuyuki; Matsushima, Shouji; Tohyama, Takeshi; Funakoshi, Kouta; Kishimoto, Junji; Itoh, Hiroshi; Komuro, Issei; Tsutsui, Hiroyuki

    HYPERTENSION RESEARCH   46 ( 5 )   1090 - 1099   2023.1

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  • EFFECTIVENESS OF STATIN INTENSIVE THERAPY IN TYPE 2 DIABETES WITH HIGH VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY Reviewed International journal

    Ikeda, Shota; Shinohara, Keisuke; Enzan, Nobuyuki; Matsushima, Shouji; Tohyama, Takeshi; Funakoshi, Kouta; Kishimoto, Junji; Itoh, Hiroshi; Komuro, Issei; Tsutsui, Hiroyuki

    JOURNAL OF HYPERTENSION   41   E44 - E45   2023.1

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  • 3-day intervention program for family members of hikikomori sufferers: A pilot randomized controlled trial Reviewed International journal

    Kubo, Hiroaki; Urata, Hiromi; Sakai, Motohiro; Nonaka, Shunsuke; Kishimoto, Junji; Saito, Kazuhiko; Tateno, Masaru; Kobara, Keiji; Fujisawa, Daisuke; Hashimoto, Naoki; Suzuki, Yuriko; Honda, Yoko; Nakao, Tomohiro; Otsuka, Kotaro; Kanba, Shigenobu; Kuroki, Toshihide; Kato, Takahiro A. A.

    FRONTIERS IN PSYCHIATRY   13   1029653   2023.1   ISSN:1664-0640

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  • EFFECTIVENESS OF STATIN INTENSIVE THERAPY IN TYPE 2 DIABETES WITH HIGH VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY

    Ikeda, S; Shinohara, K; Enzan, N; Matsushima, S; Tohyama, T; Funakoshi, K; Kishimoto, J; Itoh, H; Komuro, I; Tsutsui, H

    JOURNAL OF HYPERTENSION   41   E44 - E45   2023.1   ISSN:0263-6352 eISSN:1473-5598

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  • A predictive score for detecting vesicoureteral reflux in children with their first Escherichia coli-induced urinary tract infection Reviewed International journal

    Kurokawa, Mari; Murata, Kenji; Hoshina, Takayuki; Furuno, Kenji; Kaku, Yoshitsugu; Kishimoto, Junji; Ohga, Shouichi

    INTERNATIONAL JOURNAL OF UROLOGY   29 ( 12 )   1543 - 1550   2022.12   ISSN:0919-8172 eISSN:1442-2042

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    DOI: 10.1111/iju.15041

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  • Nintedanib plus chemotherapy for nonsmall cell lung cancer with idiopathic pulmonary fibrosis: a randomised phase 3 trial Reviewed International journal

    Otsubo, Kohei; Kishimoto, Junji; Ando, Masahiko; Kenmotsu, Hirotsugu; Minegishi, Yuji; Horinouchi, Hidehito; Kato, Terufumi; Ichihara, Eiki; Kondo, Masashi; Atagi, Shinji; Tamiya, Motohiro; Ikeda, Satoshi; Harada, Toshiyuki; Takemoto, Shinnosuke; Hayashi, Hidetoshi; Nakatomi, Keita; Kimura, Yuichiro; Kondoh, Yasuhiro; Kusumoto, Masahiko; Ichikado, Kazuya; Yamamoto, Nobuyuki; Nakagawa, Kazuhiko; Nakanishi, Yoichi; Okamoto, Isamu

    EUROPEAN RESPIRATORY JOURNAL   60 ( 6 )   2022.12

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    DOI: 10.1183/13993003.00380-2022

  • Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial Reviewed International journal

    Nakano, Yasuhiro; Yamamoto, Mitsutaka; Matoba, Tetsuya; Katsuki, Shunsuke; Nakashiro, Soichi; Takase, Susumu; Akiyama, Yusuke; Nagata, Takuya; Mukai, Yasushi; Inoue, Shujiro; Oi, Keiji; Higo, Taiki; Takemoto, Masao; Suematsu, Nobuhiro; Eshima, Kenichi; Miyata, Kenji; Usui, Makoto; Sadamatsu, Kenji; Kadokami, Toshiaki; Hironaga, Kiyoshi; Ichi, Ikuyo; Todaka, Koji; Kishimoto, Junji; Tsutsui, Hiroyuki

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   30 ( 8 )   907 - 918   2022.12   ISSN:13403478 eISSN:18803873

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    <p> <b>Aim:</b> Several clinical trials using intravascular ultrasound (IVUS) evaluation have demonstrated that intensive lipid-lowering therapy by statin or a combination therapy with statin and ezetimibe results in significant regression of coronary plaque volume. However, it remains unclear whether adding ezetimibe to statin therapy affects coronary plaque composition and the molecular mechanisms of plaque regression. We conducted this prospective IVUS analysis in a subgroup from the CuVIC trial.</p><p><b>Methods:</b> The CuVIC trial was a prospective randomized, open, blinded-endpoint trial conducted among 11 cardiovascular centers, where 260 patients with coronary artery disease who received coronary stenting were randomly allocated into either the statin group (S) or the combined statin and ezetimibe group (S+E). We enrolled 79 patients (S group, 39 patients; S+E group, 40 patients) in this substudy, for whom serial IVUS images of nonculprit lesion were available at both baseline and after 6–8 months of follow-up.</p><p><b>Results:</b> After the treatment period, the S+E group had significantly lower level of low-density lipoprotein cholesterol (LDL-C; 80.9±3.7 vs. 67.7±3.8 mg/dL, <i>p</i>=0.0143). Campesterol, a marker of cholesterol absorption, and oxysterols (β-epoxycholesterol, 4β-hydroxycholesterol, and 27-hydroxycholesterol) were also lower in the S+E group. IVUS analyses revealed greater plaque regression in the S+E group than in the S group (−6.14% vs. −1.18% for each group, <i>p</i>=0.042). It was noteworthy that the lowering of campesterol and 27-hydroxycholesterol, but not LDL-C, had a significant positive correlation with plaque regression.</p><p><b>Conclusions:</b> Compared with statin monotherapy, ezetimibe in combination with statin achieved significantly lower LDL-C, campesterol, and 27-hydroxycholesterol, which resulted in greater coronary plaque regression.</p>

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  • 大腸菌による初回尿路感染症の患児における膀胱尿管逆流症検出のための予測スコア(A predictive score for detecting vesicoureteral reflux in children with their first Escherichia coli-induced urinary tract infection)

    Kurokawa Mari, Murata Kenji, Hoshina Takayuki, Furuno Kenji, Kaku Yoshitsugu, Kishimoto Junji, Ohga Shouichi

    International Journal of Urology   29 ( 12 )   1543 - 1550   2022.12   ISSN:0919-8172

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    大腸菌による初回発熱性尿路感染症(fUTI)の患児に対し排尿時膀胱尿道造影(VCUG)を適切に行う目的で、膀胱尿管逆流症(VUR)の予測スコアの構築を試みた。全例にVCUGを行った期間(2007~2014年)ならびにVURを疑う腎・膀胱超音波(RBUS)所見を認める場合にのみVCUGを行った期間(2016~2019年)に初回fUTIにより入院した2歳未満の患児それぞれ111例(非選択群)、102例(選択群)を対象とした。非選択群では32例(29%)がVURと診断された。選択群ではVCUGを行った45例中20例(44%)がVURと診断され、VCUGを行わなかった57例中8例がfUTI再発をきたし、うち3例がVURと診断された。非選択群でVURと診断された患児のうち9例は、RBUS所見に基づいた現在のVCUG実施基準を満たさなかった。非選択群のデータを用いた多変量ロジスティック回帰分析により6因子(低年齢、女性、発熱の持続、低タンパク血症、低ナトリウム血症、高血糖)を選択し、VUR予測スコアを作成した。その結果、現在のVCUG実施基準に比べてVUR検出の感度および特異度が高かった。

  • A novel quantitative indicator for disease progression rate in amyotrophic lateral sclerosis

    Kobayakawa, Y; Todaka, K; Hashimoto, Y; Ko, S; Shiraishi, W; Kishimoto, J; Kira, J; Yamasaki, R; Isobe, N

    JOURNAL OF THE NEUROLOGICAL SCIENCES   442   120389   2022.11   ISSN:0022-510X eISSN:1878-5883

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    Objective: The current study sought to develop a new indicator for disease progression rate in amyotrophic lateral sclerosis (ALS). Methods: We used a nonparametric method to score diverse patterns of decline in the percentage of predicted forced vital capacity (%FVC) in patients with ALS. This involved 6317 longitudinal %FVC data sets from 920 patients in the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database volunteered by PRO-ACT Consortium members. To assess the utility of the derived scores as a disease indicator, we examined changes over time, the association with prognosis, and correlation with the Risk Profile of the Treatment Research Initiative to Cure ALS (TRICALS). Our local cohort (n = 92) was used for external validation. Results: We derived scores ranging from 35 to 106 points to construct the FVC Decline Pattern scale (FVC-DiP). Individuals' FVC-DiP scores were determined from a single measurement of %FVC and disease duration at assessment. Although the %FVC declined over the disease course (p < 0.0001), the FVC-DiP remained relatively stable. Low FVC-DiP scores were associated with rapid disease progression. Using our cohort, we demonstrated an association between FVC-DiP and the survival prognosis, the stability of the FVC-DiP per individual, and a correlation between FVC-DiP scores and the TRICALS Risk Profile (r2 = 0.904, p < 0.0001). Conclusions: FVC-DiP scores reflected patterns of declining %FVC over the natural course of ALS and indicated the disease progression rate. The FVC-DiP may enable easy assessment of disease progression patterns and could be used for assessing treatment efficacy.

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  • ASXL1 mutations with serum EPO levels predict poor response to darbepoetin alfa in lower-risk MDS: W-JHS MDS01 trial Reviewed International journal

    Morita, Yasuyoshi; Nannya, Yasuhito; Ichikawa, Motoshi; Hanamoto, Hitoshi; Shibayama, Hirohiko: Maeda, Yoshinobu; Hata, Tomoko; Miyamoto, Toshihiro; Kawabata, Hiroshi; Takeuchi, Kazuto; Tanaka, Hiroko; Kishimoto, Junji; Miyano, Satoru; Matsumura, Itaru; Ogawa, Seishi; Akashi, Koichi; Kanakura, Yuzuru; Mitani, Kinuko

    INTERNATIONAL JOURNAL OF HEMATOLOGY   116 ( 5 )   659 - 668   2022.11   ISSN:0925-5710 eISSN:1865-3774

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  • A novel quantitative indicator for disease progression rate in amyotrophic lateral sclerosis Reviewed International journal

    Kobayakawa, Yuko; Todaka, Koji; Hashimoto, Yu; Ko, Senri; Shiraishi, Wataru; Kishimoto, Junji; Kira, Jun-ichi; Yamasaki, Ryo; Isobe, Noriko

    JOURNAL OF THE NEUROLOGICAL SCIENCES   442   2022.11

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  • A Phase II Trial on Osimertinib as a First-Line Treatment for EGFR Mutation-Positive Advanced NSCLC in Elderly Patients: The SPIRAL-0 Study Reviewed International journal

    Chihara, Yusuke; Takeda, Takayuki; Goto, Yasuhiro; Nakamura, Yoichi; Tsuchiya-Kawano, Yuko; Nakao, Akira; Onoi, Keisuke; Hibino, Makoto; Fukuda, Minoru; Honda, Ryoichi; Yamada, Takahiro; Taniguchi, Ryusuke; Sakamoto, Sinjiro; Date, Koji; Nagashima, Seiji; Tanzawa, Shigeru; Minato, Koichi; Nakatani, Koichi; Izumi, Miiru; Shimose, Takayuki; Kishimoto, Junji; Uchino, Junji; Takayama, Koichi

    ONCOLOGIST   27 ( 11 )   903 - E834   2022.11   ISSN:1083-7159 eISSN:1549-490X

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  • Nab-Paclitaxel for Previously Treated Advanced Non-Small Cell Lung Cancer: Analysis of Safety and Efficacy for Patients With Renal Impairment Reviewed International journal

    Yoneshima, Yasuto; Morita, Satoshi; Ando, Masahiko; Nakamura, Atsushi; Iwasawa, Shunichiro; Yoshioka, Hiroshige; Goto, Yasuhiro; Takeshita, Masafumi; Harada, Toshiyuki; Hirano, Katsuya; Oguri, Tetsuya; Kondo, Masashi; Miura, Satoru; Hosomi, Yukio; Kato, Terufumi; Kubo, Toshio; Kishimoto, Junji; Yamamoto, Nobuyuki; Nakanishi, Yoichi; Okamoto, Isamu

    CLINICAL LUNG CANCER   23 ( 7 )   585 - 592   2022.11   ISSN:1525-7304 eISSN:1938-0690

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    DOI: 10.1016/j.cllc.2022.08.011

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  • ASXL1変異と血清EPO値は低リスクMDSにおけるダルベポエチンアルファへの不良な反応を予測する W-JHS MDS01試験(ASXL1 mutations with serum EPO levels predict poor response to darbepoetin alfa in lower-risk MDS: W-JHS MDS01 trial)

    Morita Yasuyoshi, Nannya Yasuhito, Ichikawa Motoshi, Hanamoto Hitoshi, Shibayama Hirohiko, Maeda Yoshinobu, Hata Tomoko, Miyamoto Toshihiro, Kawabata Hiroshi, Takeuchi Kazuto, Tanaka Hiroko, Kishimoto Junji, Miyano Satoru, Matsumura Itaru, Ogawa Seishi, Akashi Koichi, Kanakura Yuzuru, Mitani Kinuko

    International Journal of Hematology   116 ( 5 )   659 - 668   2022.11   ISSN:0925-5710

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    低リスク骨髄異形成症候群(MDS)の貧血に対する持続型赤血球造血刺激因子製剤ダルベポエチンアルファ(DA)の効果を予測するための遺伝子変異について検討した。主要評価項目は、DA(240μg/週)投与開始後16週目の高頻度(10%以上)遺伝子変異と国際ワーキンググループクライテリア2006による血液学的改善-赤血球反応の相関であった。低リスクMDS患者79例(年齢29~90歳)を対象とした。頻繁に変異していた(10%以上)遺伝子は、SF3B1(24例、30.4%)、TET2(20例、25.3%)、SRSF2(10例、12.7%)、ASXL1(9例、11.4%)、DNMT3A(8例、10.1%)であった。DAに対する全奏効率は70.9%であった。ベースラインの血清エリスロポエチン(EPO)値および赤血球輸血量を変数として含む多変量解析の結果、EPO値およびASXL1遺伝子の変異は、奏効率の悪化と有意に関連していた(オッズ比0.146、95%CI 0.042~0.503、p=0.0023;オッズ比0.175、95%CI 0.033~0.928、p=0.0406)。以上より、EPO濃度が高く、ASXL1遺伝子変異を保有する貧血のMDS患者は、DAに対する反応性が不良である可能性が示された。

  • Reliability, validity, and responsiveness of the Japanese version of the EORTC QLQ-ELD14 in evaluating the health-related quality of life of elderly patients with cancer Invited Reviewed International journal

    Kinoshita, Yumiko; Izukura, Rieko; Kishimoto, Junji; Kanaoka, Maki; Fujita, Hayato; Ando, Koji; Nagai, Shuntaro; Akiyoshi, Sayuri; Tagawa, Tetsuzo; Kubo, Makoto; Inokuchi, Junichi; Ohuchida, Kenoki; Oki, Eiji; Tanaka, Kentaro; Eto, Masatoshi; Yoshizumi, Tomoharu; Nakamura, Masafumi; Chishaki, Akiko

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   149 ( 8 )   4899 - 4914   2022.10   ISSN:0171-5216 eISSN:1432-1335

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  • Association of thyroid transcription factor-1 (TTF-1) expression with efficacy of PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in advanced non-squamous non-small cell lung cancer Reviewed International journal

    Ibusuki, Ritsu; Yoneshima, Yasuto; Hashisako, Mikiko; Matsuo, Norikazu; Harada, Taishi; Tsuchiya-Kawano, Yuko; Kishimoto, Junji; Ota, Keiichi; Shiraishi, Yoshimasa; Iwama, Eiji; Tanaka, Kentaro; Oda, Yoshinao; Okamoto, Isamu

    TRANSLATIONAL LUNG CANCER RESEARCH   11 ( 11 )   2208 - 2215   2022.9   ISSN:2218-6751 eISSN:2226-4477

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  • 医療刑務所における神経症やせ症女性患者に関する研究 ー 第一報:特徴的な諸群への分類 ー Reviewed

    瀧井正人, 岸本淳司, 遠山岳詩, 海原美香, 須藤信之, 迎伸彦

    精神神経学雑誌   124 ( 9 )   601 - 622   2022.9

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  • Phase II study of carboplatin/nab-paclitaxel/atezolizumab combination therapy for advanced nonsquamous non-small cell lung cancer patients with impaired renal function: RESTART trial Reviewed International journal

    Shiraishi, Yoshimasa; Kishimoto, Junji; Shimose, Takayuki; Toi, Yukihiro; Sugawara, Shunichi; Okamoto, Isamu

    BMC CANCER   22 ( 1 )   964   2022.9   eISSN:1471-2407

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  • 医療刑務所における神経性やせ症女性患者に関する研究(第一報) 特徴的な諸群への分類

    瀧井 正人, 岸本 淳司, 遠山 岳詩, 海原 美香, 須藤 信行, 迎 伸彦

    精神神経学雑誌   124 ( 9 )   601 - 622   2022.9   ISSN:0033-2658

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    わが国の矯正施設では近年摂食障害(ED)の受刑者が増加し,女子刑務所などの現場では対応に大変苦慮している.重篤で一般刑務所では対応困難な症例は,医療刑務所に移送される.北九州医療刑務所(以下,当所)では,患者の受け入れを2012年5月より開始し集約的な治療を行ってきた.【目的】当所に入所した100人の神経性やせ症(AN)女性患者を分類し比較することにより,その病態理解を進める.【方法】矯正施設初回入所以前の,EDの病歴と覚醒剤乱用歴の有無により,「ED病歴(+)覚醒剤歴(-)」群,「ED病歴(-)覚醒剤歴(-)」群,「覚醒剤歴(+)ED病歴(+)」群,「覚醒剤歴(+)ED病歴(-)」群に分類し,人口統計学的,臨床的,心理社会的データの比較を行った.【結果】大多数を占めたのは「ED病歴(+)覚醒剤歴(-)」群(n=74)であり,若くして典型的なEDを発症しきわめて長い病歴をもった,重症遷延性神経性やせ症(SEAN)であった.「ED病歴(-)覚醒剤歴(-)」群(n=13)は,中高年になり逮捕や収容を契機にEDを出現させていた.「覚醒剤歴(+)ED病歴(-)」群(n=9)は,矯正施設収容以後に,ほぼ矯正施設内限定でEDの症状を出現させていた.「ED病歴(-)覚醒剤歴(-)」群と「覚醒剤歴(+)ED病歴(-)」群は非典型的なEDの病像を示し,やせ願望は比較的軽度であった.重篤で長いED病歴をもつ「ED病歴(+)覚醒剤歴(-)」群においても,矯正施設初回入所以前にED治療を受けた者は,約半数にすぎなかった.【考察】ANの女性受刑者は均一の集団ではなく,治療や対応はそれぞれの病態に適合させる必要があるため,これらの分類は治療のために有益である.「ED病歴(+)覚醒剤歴(-)」群は,数の多さからもEDの典型性や重篤性からも臨床的に特に重要である.医療刑務所のAN患者の病態や治療について,今後も系統的多面的に研究を進め,報告する予定である.(著者抄録)

  • Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study (vol 6, 100191, 2021)

    Hotta, K; Saeki, S; Yamaguchi, M; Harada, D; Bessho, A; Tanaka, K; Inoue, K; Gemba, K; Shiojiri, M; Kato, Y; Ninomiya, T; Kubo, T; Kishimoto, J; Shioyama, Y; Katsui, K; Sasaki, J; Kiura, K; Sugio, K

    ESMO OPEN   7 ( 4 )   100532   2022.8   eISSN:2059-7029

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    The authors regret that despite our best care and attention, we have discovered one error in text and corresponding errors in Table 3 and Supplementary Table S2. 1) One error, placed in the “Toxicity” paragraph in Results section has now been corrected as follows:“Radiation pneumonitis, the most clinically important toxicity, occurred in 14 (82%; grade 1) and 2 (12%; grade 2) patients; …”. 2) In Table 3, number and proportion of those with any grade radiation pneumonitis in CRT phase have also been corrected as “16 (94)”.3) Supplementary Table S2 has also been corrected, according to the former correction of number of patients who had pneumonitis events from 14 to 16.The authors would like to apologize for any inconvenience caused.

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  • Efficacy and Safety of Sitafloxacin in Treating Low-risk Febrile Neutropenia in Patients with Lung Cancer

    On Rintaro, Matsumoto Takemasa, Ebi Noriyuki, Doi Seiji, Ishii Hiroshi, Furugen Makoto, Fujita Jiro, Ide Maako, Kishimoto Junji, Okamoto Isamu, Fujita Masaki, Lung Oncology Group in Kyushu (LOGIK)

    JMA Journal   5 ( 3 )   334 - 340   2022.7   ISSN:2433328X eISSN:24333298

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    <p><b>Introduction:</b> Febrile episodes in patients with cancer and chemotherapy-induced neutropenia can be life-threatening and generally require prompt administration of broad-spectrum antimicrobials. However, little evidence exists for treating patients with solid tumors and febrile neutropenia (FN) with oral antimicrobials.</p><p><b>Methods:</b> In this prospective study, we aimed to determine the efficacy and safety of sitafloxacin (STFX) for treating FN in lung cancer patients. In this prospective study, low-risk FN patients with lung cancer received STFX. The primary endpoint was response rate, defined as 5 sequential days of absence of fever without adverse events. The study was registered as UMIN000010911.</p><p><b>Results:</b> As a result, STFX was administered to 26 patients, all of whom survived during its administration. Of the 26, 14 completed primary endpoint (53.85%). The low response rate was attributed to occurrence of fevers of unknown cause rather than failure of FN treatment. Only two patients received antibacterial agents other than STFX. If response rate omitted absence of fever and been defined only as recovery from FN without changing microbial agents or serious complications, the response rate would have been 91.67%. Adverse events occurred in eight patients, none of which were serious.</p><p><b>Conclusions:</b> In conclusion, STFX might be used to treat low-risk FN in patients with lung cancer; however, a more detailed study will be required in future.</p>

    DOI: 10.31662/jmaj.2021-0227

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  • Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial-KABUKI trial Reviewed International journal

    Hosokawa, Kazuya; Abe, Kohtaro; Kishimoto, Junji; Kobayakawa, Yuko; Todaka, Koji; Tamura, Yuichi; Tatsumi, Koichiro; Inami, Takumi; Ikeda, Nobutaka; Taniguchi, Yu; Minatsuki, Shun; Murohara, Toyoaki; Yasuda, Satoshi; Fukuda, Keiichi; Tsutsui, Hiroyuki

    BMJ OPEN   12 ( 7 )   e061225   2022.7   ISSN:2044-6055

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    DOI: 10.1136/bmjopen-2022-061225

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  • Efficacy and Safety of Sitafloxacin in Treating Low-risk Febrile Neutropenia in Patients with Lung Cancer. Reviewed International journal

    On, Rintaro; Matsumoto, Takemasa; Ebi, Noriyuki; Doi, Seiji; Ishii, Hiroshi; Furugen, Makoto; Fujita, Jiro; Ide, Maako; Kishimoto, Junji; Okamoto, Isamu; Fujita, Masaki

    JMA Journal   5 ( 3 )   334 - 340   2022.7

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  • 肺癌患者の低リスク発熱性好中球減少症に対するシタフロキサシンの有効性および安全性(Efficacy and Safety of Sitafloxacin in Treating Low-risk Febrile Neutropenia in Patients with Lung Cancer)

    On Rintaro, Matsumoto Takemasa, Ebi Noriyuki, Doi Seiji, Ishii Hiroshi, Furugen Makoto, Fujita Jiro, Ide Maako, Kishimoto Junji, Okamoto Isamu, Fujita Masaki

    JMA Journal   5 ( 3 )   334 - 340   2022.7   ISSN:2433-328X

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    肺癌患者を対象とした前向き研究を実施し、発熱性好中球減少症に対するシタフロキサシン(STFX)の有効性および安全性について検討した。低リスク(MASCCスコア>21)発熱性好中球減少症肺癌患者26例(男性19例、中央値70.0歳)を対象にSTFXを投与した。主要評価項目は奏効率(有害事象を伴わない連続5日間の発熱停止と定義)、副次評価項目は72時間後、7日目、14日目での発熱の有無および安全性とした。その結果、14例(53.85%)で主要評価項目の達成が認められた。STFX以外の抗菌薬投与は2例でのみ認められた。奏効率を微生物変化や重篤な合併症を伴わない発熱性好中球減少症からの回復と定義した場合の奏効率は91.67%であった。72時間後、7日後、14日後に発熱が認められなかった割合は、それぞれ53.84%、86.36%、77.78%であった。有害事象は8例に認められたが、いずれも重篤ではなかった。以上から、STFX投与が肺癌患者における低リスク発熱性好中球減少症に対して有用である可能性が示唆された。

  • Serial measurement of B-type natriuretic peptide and future cardiovascular events in patients with type 2 diabetes mellitus without known cardiovascular disease Reviewed International journal

    Ikeda, S; Shinohara, K; Enzan, N; Matsushima, S; Tohyama, T; Funakoshi, K; Kishimoto, J; Itoh, H; Komuro, I; Tsutsui, H

    INTERNATIONAL JOURNAL OF CARDIOLOGY   356   98 - 104   2022.6   ISSN:0167-5273 eISSN:1874-1754

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  • Safety, tolerability, and anti-fibrotic efficacy of the CBP/beta-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study. Reviewed International journal

    Kimura, Kiminori; Kanto, Tatsuya; Shimoda, Shinji; Harada, Kenichi; Kimura, Masamichi; Nishikawa, Koji; Imamura, Jun; Ogawa, Eiichi; Saio, Masanao; Ikura, Yoshihiro; Okusaka, Takuji; Inoue, Kazuaki; Ishikawa, Tetsuya; Ieiri, Ichiro; Kishimoto, Junji; Todaka, Koji; Kamisawa, Terumi.

    EBioMedicine   80   104069   2022.3   ISSN:2352-3964

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  • Nintedanib plus chemotherapy for non-small cell lung cancer with IPF: a randomized phase 3 trial. Reviewed International journal

    Otsubo, Kohei; Kishimoto, Junji; Ando, Masahiko; Kenmotsu, Hirotsugu; Minegishi, Yuji; Horinouchi, Hidehito; Kato, Terufumi; Ichihara, Eiki; Kondo, Masashi; Atagi, Shinji; Tamiya, Motohiro; Ikeda, Satoshi; Harada, Toshiyuki; Takemoto, Shinnosuke; Hayashi, Hidetoshi; Nakatomi, Keita; Kimura, Yuichiro; Kondoh, Yasuhiro; Kusumoto, Masahiko; Ichikado, Kazuya; Yamamoto, Nobuyuki; Nakagawa, Kazuhiko; Nakanishi, Yoichi; Okamoto, Isamu

    The European respiratory journal   2022.3

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    DOI: 10.1183/13993003.00380-2022

  • Trastuzumab emtansine for patients with non-small cell lung cancer positive for human epidermal growth factor receptor 2 exon-20 insertion mutations Reviewed International journal

    Iwama, E; Zenke, Y; Sugawara, S; Daga, H; Morise, M; Yanagitani, N; Sakamoto, T; Murakami, H; Kishimoto, J; Matsumoto, S; Nakanishi, Y ; Goto, K; Okamoto, I

    EUROPEAN JOURNAL OF CANCER   162   99 - 106   2022.2   ISSN:0959-8049 eISSN:1879-0852

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  • Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study Reviewed International journal

    Shinohara, K; Ikeda, S; Enzan, N; Matsushima, S; Tohyama, T; Funakoshi, K; Kishimoto, J; Itoh, H; Komuro, I; Tsutsui, H

    HYPERTENSION RESEARCH   44 ( 12 )   1606 - 1616   2021.12

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    DOI: 10.1038/s41440-021-00734-x

  • An Open-label Phase I/IIa Clinical Trial of 11 beta-HSD1 Inhibitor for Cushing's Syndrome and Autonomous Cortisol Secretion Reviewed International journal

    Oda, S; Ashida, K; Uchiyama, M; Sakamoto, S; Hasuzawa, N; Nagayama, A; Wang, LX; Nagata, H; Sakamoto, R; Kishimoto, J; Todaka, K; Ogawa, Y; Nakanishi, Y; Nomura, M

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   106 ( 10 )   E3865 - E3880   2021.10

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    DOI: 10.1210/clinem/dgab450

  • Machine learning-based model for predicting 1 year mortality of hospitalized patients with heart failure Reviewed International journal

    Tohyama, T; Ide, T; Ikeda, M; Kaku, H; Enzan, N; Matsushima, S; Funakoshi, K; Kishimoto, J; Todaka, K; Tsutsui, H

    ESC HEART FAILURE   8 ( 5 )   4077 - 4085   2021.10

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  • Study protocol for a multicentre, open-label, single-arm phase I/II trial to evaluate the safety and efficacy of ripasudil 0.4% eye drops for retinopathy of prematurity Reviewed International journal

    Arima, Mitsuru Inoue, Hirosuke Nakao, Shintaro Misumi, Akiko Suzuki, Maya Matsushita, Itsuka Araki, Shunsuke Yamashiro, Chiemi Takahashi, Kazumasa Ochiai, Masayuki Yoshida, Noriko Hirose, Masayuki Kishimoto, Junji Todaka, Koji Hasegawa, Shunji Kimura, Kazuhiro Kusuhara, Koichi Kondo, Hiroyuki Ohga, Shouichi Sonoda, Koh-Hei

    BMJ OPEN   11 ( 7 )   2021.9

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    DOI: 10.1136/bmjopen-2020-047003

  • Phase 3 Trial Comparing Nanoparticle Albumin-Bound Paclitaxel With Docetaxel for Previously Treated Advanced NSCLC Reviewed International journal

    Yoneshima, Y; Morita, S; Ando, M; Nakamura, A; Iwasawa, S; Yoshioka, H; Goto, Y; Takeshita, M; Harada, T; Hirano, K; Oguri, T; Kondo, M; Miura, S; Hosomi, Y; Kato, T; Kubo, T; Kishimoto, J; Yamamoto, N; Nakanishi, Y; Okamoto, I

    JOURNAL OF THORACIC ONCOLOGY   16 ( 9 )   1523 - 1532   2021.9

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    DOI: 10.1016/j.jtho.2021.03.027

  • Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study Reviewed International journal

    Hotta, K; Saeki, S; Yamaguchi, M; Harada, D; Bessho, A; Tanaka, K; Inoue, K; Gemba, K; Shiojiri, M; Kato, Y; Ninomiya, T; Kubo, T; Kishimoto, J; Shioyama, Y; Katsui, K; Sasaki, J; Kiura, K; Sugio, K

    ESMO OPEN   6 ( 4 )   2021.8

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  • Development of Quality of Life Questionnaire for Patients with Parkinson's Disease Undergoing STN-DBS Reviewed International journal

    Kawaguchi, M; Miyagi, Y; Kishimoto, J; Samura, K; Tokunaga, Y; Watari, M; Eguchi, H; Ueda, S; Iihara, K

    NEUROLOGIA MEDICO-CHIRURGICA   61 ( 8 )   475 - 483   2021.8

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    DOI: 10.2176/nmc.oa.2020-0388

  • Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan Reviewed International journal

    Murata, K; Onoyama, S; Yamamura, K; Mizuno, Y; Furuno, K; Matsubara, K; Hatae, K; Masuda, K; Nomura, Y; Ohno, T; Kinumaki, A; Miura, M; Sakai, Y ; Ohga, S; Fukushima, W; Kishimoto, J; Nakamura, Y; Hara, T

    VACCINES   9 ( 8 )   2021.8

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    DOI: 10.3390/vaccines9080839

  • Effectiveness of statin intensive therapy in type 2 diabetes mellitus with high visit-to-visit blood pressure variability Invited Reviewed International journal

    Ikeda, S Shinohara, K Enzan, N Matsushima, S Tohyama, T Funakoshi, K Kishimoto, J Itoh, H Komuro, I Tsutsui, H

    JOURNAL OF HYPERTENSION   39 ( 7 )   1435 - 1443   2021.7

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    DOI: 10.1097/HJH.0000000000002823

  • Development of a 3-Day Intervention Program for Family Members of Hikikomori Sufferers Invited Reviewed International journal

    Kubo, H Urata, H Sakai, M Nonaka, S Kishimoto, J Saito, K Tateno, M Kobara, K Fujisawa, D Hashimoto, N Suzuki, Y Honda, Y Otsuka, K Kanba, S Kuroki, T Kato, TA

    JAPANESE PSYCHOLOGICAL RESEARCH   65 ( 2 )   190 - 199   2021.6   ISSN:0021-5368 eISSN:1468-5884

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    DOI: 10.1111/jpr.12368

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  • Original Research Osimertinib versus osimertinib plus chemotherapy for non-small cell lung cancer with EGFR (T790M)-associated resistance to initial EGFR inhibitor treatment: An open-label, randomised phase 2 clinical trial Invited Reviewed International journal

    Tanaka, K Asahina, H Kishimoto, J Miyata, Y Uchida, T Watanabe, K Hamai, K Harada, T Tsubata, Y Sugawara, S Kobayashi, K Sugio, K Oizumi, S Okamoto, I

    EUROPEAN JOURNAL OF CANCER   149   14 - 22   2021.5

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    DOI: 10.1016/j.ejca.2021.02.019

  • Effects of Medications and Subthalamic Nucleus-Deep Brain Stimulation on the Cutaneous Silent Period in Patients With Parkinson's Disease Invited Reviewed International journal

    Urasaki, E Miyagi, Y Kishimoto, J

    NEUROMODULATION   25 ( 6 )   854 - 865   2021.5   ISSN:10947159

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  • Clinical Trial of a Cancer Vaccine Targeting VEGF and KIF20A in Advanced Biliary Tract Cancer Invited Reviewed International journal

    Murahashi, M Tsuruta, T Yamada, K Hijikata, Y Ogata, H Kishimoto, J Yoshimura, S Hikichi, T Nakanishi, Y Tani, K

    ANTICANCER RESEARCH   41 ( 3 )   1485 - 1496   2021.3

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    DOI: 10.21873/anticanres.14907

  • Mechanisms of acquired resistance to osimertinib in advanced NSCLC with EGFR T790M mutation (LOGIK1607) Invited Reviewed International journal

    Yamaguchi, M Osoegawa, A Nakamura, T Morinaga, R Tanaka, K Kashiwabara, K Miura, T Suetsugu, T Taguchi, K Nabeshima, K Kishimoto, J Sakai, K Nishio, K Sugio, K

    CANCER SCIENCE   112   567 - 567   2021.2

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  • ASXL1 Mutations Predict a Poor Response to Darbepoetin Alfa in Anemic Patients with Low-Risk MDS: A Multicenter, Phase II Study Invited Reviewed International journal

    Hanamoto, H Morita, Y Ichikawa, M Nannya, Y Shibayama, H Maeda, Y Hata, T Miyamoto, T Kawabata, H Takeuchi, K Tanaka, H Kishimoto, J Miyano, S Matsumura, I Ogawa, S Akashi, K Kanakura, Y Mitani, K

    BLOOD   136   2020.11

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    DOI: 10.1182/blood-2020-134483

  • Plasma B-type Natriuretic Peptide Levels Are Associated With Future Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Known Cardiovascular Disease Invited Reviewed International journal

    Ikeda, S Shinohara, K Enzan, N Matsushima, S Tohyama, T Funakoshi, K Kishimoto, J Itoh, H Komuro, I Tsutsui, H

    CIRCULATION   142   2020.11

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  • Myeloablative intravenous busulfan-containing regimens for allo-HSCT in AML or MDS patients over 54 years old: combined results of three phase II studies Invited Reviewed International journal

    Uchida, N Matsumoto, K Sakura, T Hidaka, M Miyamoto, T Eto, T Maeda, Y Murayama, T Fujishima, N Yoshimoto, G Morita, K Kishimoto, J Teshima, T Taniguchi, S Yamashita, T Mori, S Akashi, K Harada, M

    INTERNATIONAL JOURNAL OF HEMATOLOGY   112 ( 4 )   510 - 523   2020.10

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    DOI: 10.1007/s12185-020-02941-7

  • Safety and efficacy of brilliant blue g250 (BBG) for lens capsular staining: a phase III physician-initiated multicenter clinical trial Invited Reviewed International journal

    Hisatomi, T Enaida, H Yoshida, S Hirakata, A Ohji, M Nishida, K Kubota, T Ogata, N Matsui, T Kimura, K Sonoda, KH Uchiyama, M Kishimoto, J Todaka, K Nakanishi, Y Ishibashi, T

    JAPANESE JOURNAL OF OPHTHALMOLOGY   64 ( 5 )   455 - 461   2020.9

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  • Treatment Rationale and Design for APPLE (WJOG11218L): A Multicenter, Open-Label, Randomized Phase 3 Study of Atezolizumab and Platinum/Pemetrexed With or Without Bevacizumab for Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer Invited Reviewed International journal

    Shiraishi, Y Kishimoto, J Tanaka, K Sugawara, S Daga, H Hirano, K Azuma, K Hataji, O Hayashi, H Tachihara, M Mitsudomi, T Seto, T Nakagawa, K Yamamoto, N Okamoto, I

    CLINICAL LUNG CANCER   21 ( 5 )   472 - 476   2020.9

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  • Effectiveness Of Intensive Lipid-lowering Therapy With Statins In Type 2 Diabetes Mellitus Patients With Poorly Controlled Blood Pressure Invited Reviewed International journal

    Ikeda, S Shinohara, K Enzan, N Matsushima, S Tohyama, T Funakoshi, K Kishimoto, J Itoh, H Komuro, I Tsutsui, H

    HYPERTENSION   76   2020.9

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  • Effects of intensive exercise, combined with dapagliflozin on body composition in type 2 diabetes: a randomised controlled trial Invited Reviewed International journal

    Bouchi, R Sonoda, N Itoh, J Ono, Y Fukuda, T Takeuchi, T Kishimoto, J Yamada, T Ogawa, Y

    DIABETOLOGIA   63 ( SUPPL 1 )   S275 - S275   2020.9

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  • Randomised phase II study of panitumumab plus irinotecan versus cetuximab plus irinotecan in patients with KRAS wild-type metastatic colorectal cancer refractory to fluoropyrimidine, irinotecan and oxaliplatin (WJOG 6510G) Invited Reviewed International journal

    Sakai, D Taniguchi, H Sugimoto, N Tamura, T Nishina, T Hara, H Esaki, T Denda, T Sakamoto, T Okuda, H Satoh, T Tsushima, T Makiyama, A Tsuda, T Hosokawa, A Kuramochi, H Tokunaga, S Moriwaki, T Yasui, H Ishida, H Tsuji, A Otsu, S Shimokawa, H Baba, E Sato, M Matsumoto, S Ozaki, Y Shinozaki, K Tamagawa, H Goto, M Kadowaki, S Fujii, H Koh, Y Yamazaki, K Hironaka, S Kishimoto, J Boku, N Hyodo, I Muro, K

    EUROPEAN JOURNAL OF CANCER   135   11 - 21   2020.8

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  • Phase II trial of adjuvant mFOLFOX6 after metastasectomy for pulmonary metastasis of colorectal cancer: WJOG5810G. Invited Reviewed International journal

    Machida, N Okumura, T Kishimoto, J Boku, N Nishina, T Suyama, K Ohde, Y Shinozaki, K Baba, H Tokunaga, S Kawakami, H Tsuda, T Kotaka, M Okuda, H Yasui, H Denda, T Yamazaki, K Hironaka, S Muro, K Hyodo, I

    JOURNAL OF CLINICAL ONCOLOGY   38 ( 15 )   2020.5

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  • Exploratory retrospective study of risk factors for thromboembolism treated with multi-kinase inhibitor pazopanib or Lenvatinib. Invited Reviewed International journal

    Nio, K Tsuchihashi, K Taguchi, K Yoshihiro, T Yamaguchi, K Ito, M Moriyama, S Fukata, M Fujiwara, T Setsu, N Endo, M Matsumoto, Y Nakashima, Y Wakasaki, T Yasumatsu, R Ariyama, H Kusaba, H Kishimoto, J Akashi, K Baba, E

    International Journal of Surgery Oncology   5   e89   2020.5

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  • An Observational Study of Team Management Approach for CapeOX Therapy in Patients with Advanced and Recurrent Colorectal Cancer: SMILE Study (The Study of Metastatic colorectal cancer to investigate the Impact of Learning Effect) Reviewed International journal

    Matsuoka, H Ogata, Y Nakamura, M Shibata, Y Munemoto, Y Bando, H Nishijima, K Okuda, H Terada, I Shiroiwa, T Kishimoto, J Maeda, K

    JOURNAL OF THE ANUS RECTUM AND COLON   4 ( 2 )   79 - 84   2020.4

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  • Mallampati test with phonation, tongue protrusion and supine position is most correlated with Cormack-Lehane test Reviewed International journal

    Ouchi, K Hosokawa, R Yamanaka, H Nakajima, Y Nakamura, Y Kishimoto, J

    ODONTOLOGY   2020.2

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  • Development of 5-day hikikomori intervention program for family members: A single-arm pilot trial Reviewed International journal

    Kubo, H Urata, H Sakai, M Nonaka, S Saito, K Tateno, M Kobara, K Hashimoto, N Fujisawa, D Suzuki, Y Otsuka, K Kamimae, H Muto, Y Usami, T Honda, Y Kishimoto, J Kuroki, T Kanba, S Kato, TA

    HELIYON   6 ( 1 )   2020.1

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  • Revealing the mechanisms of acquired resistance to osimertinib from re-biopsy specimens in advanced non-small cell lung cancer with EGFR T790M mutation (LOGIK1607) Reviewed International journal

    Osoegawa, A Yamaguchi, M Nakamura, T Morinaga, R Tanaka, K Kashiwabara, K Taguchi, K Nabeshima, K Kishimoto, J Sugio, K

    MOLECULAR CANCER THERAPEUTICS   18 ( 12 )   2019.12

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  • Longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor-tyrosine kinase inhibitors Reviewed International journal

    Iwama, E Sakai, K Hidaka, N Inoue, K Fujii, A Nakagaki, N Ota, K Toyozawa, R Azuma, K Nakatomi, K Harada, T Hisasue, J Sakata, S Shimose, T Kishimoto, J Nakanishi, Y Nishio, K Okamoto, I

    CANCER   2019.9

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  • Updated Survival Data for a Phase I/II Study of Carboplatin plus Nab-Paclitaxel and Concurrent Radiotherapy in Patients with Locally Advanced Non-Small Cell Lung Cancer Reviewed International journal

    Tsuchiya-Kawano, Y Sasaki, T Yamaguchi, H Hirano, K Horiike, A Satouchi, M Hosokawa, S Morinaga, R Komiya, K Inoue, K Fujita, Y Toyozawa, R Kimura, T Takahashi, K Nishikawa, K Kishimoto, J Nakanishi, Y Okamoto, I

    ONCOLOGIST   25 ( 6 )   475   2019.6

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  • Randomized phase II study of pemetrexed or pemetrexed plus bevacizumab for elderly patients with previously untreated non-squamous non-small cell lung cancer Results of the Lung Oncology Group in Kyushu (LOGIK1201) Reviewed

    Minoru Fukuda, Takeshi Kitazaki, Daiki Ogawara, Masao Ichiki, Hiroshi Mukae, Riichiroh Maruyama, Noriaki Nakagaki, Midori Shimada, Takaya Ikeda, Junji Kishimoto, Taishi Harada, Takashi Seto, Noriyuki Ebi, Koichi Takayama, Isamu Okamoto, Yukito Ichinose, Kenji Sugio

    Lung Cancer   132   1 - 8   2019.6

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    DOI: 10.1016/j.lungcan.2019.01.008

  • Promoting Patient Care Through Communication Training in a Pre-clerkship Pharmacy Education Course in Japan Reviewed International journal

    Epp, DA Kubota, T Yoshida, M Kishimoto, J Kobayashi, D Shimazoe, T

    AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION   83 ( 5 )   2019.6

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  • Updated survival date of phase I/II study of carboplatin plus nab-paclitaxel and concurrent radiotherapy for patients with locally advanced non-small cell lung cancer. Reviewed International journal

    Horiike, A Kawano, Y Sasaki, T Yamaguchi, H Hirano, K Satouchi, M Hosokawa, S Morinaga, R Komiya, K Inonue, K Fujita, Y Toyozawa, R Kimura, T Takahashi, K Nishikawa, K Kishimoto, J Nakanishi, Y Okamoto, I

    JOURNAL OF CLINICAL ONCOLOGY   37 ( 15 )   2019.5

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  • T-bet + lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer Reviewed

    Hitomi Mori, Makoto Kubo, Masaya Kai, Mai Yamada, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Tomofumi Osako, Reiki Nishimura, Nobuyuki Arima, Masayuki Okido, Junji Kishimoto, Yoshinao Oda, Masafumi Nakamura

    Breast Cancer Research and Treatment   2019.1

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    DOI: 10.1007/s10549-019-05256-2

  • Role of Predictive Value of the Modified Glasgow Prognostic Score for Later-line Chemotherapy in Patients With Metastatic Colorectal Cancer Reviewed

    Kenji Tsuchihashi, Mamoru Ito, Toshikazu Moriwaki, Shota Fukuoka, Hiroya Taniguchi, Atsuo Takashima, Yosuke Kumekawa, Takeshi Kajiwara, Kentaro Yamazaki, Taito Esaki, Akitaka Makiyama, Tadamichi Denda, Hironaga Satake, Takeshi Suto, Naotoshi Sugimoto, Kenji Katsumata, Toshiaki Ishikawa, Tomomi Kashiwada, Eiji Oki, Yoshito Komatsu, Hiroyuki Okuyama, Daisuke Sakai, Hideki Ueno, Takao Tamura, Kimihiro Yamashita, Junji Kishimoto, Yasuhiro Shimada, Eishi Baba

    Clinical Colorectal Cancer   17 ( 4 )   e687 - e697   2018.12

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    DOI: 10.1016/j.clcc.2018.07.004

  • Retinal flow density by optical coherence tomography angiography is useful for detection of nonperfused areas in diabetic retinopathy Reviewed

    Yoshihiro Kaizu, shintaro nakao, Haruka Sekiryu, Iori Wada, Muneo Yamaguchi, Toshio Hisatomi, Yasuhiro Ikeda, Junji Kishimoto, Kohei Sonoda

    Graefe's Archive for Clinical and Experimental Ophthalmology   256 ( 12 )   2275 - 2282   2018.12

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    DOI: 10.1007/s00417-018-4122-6

  • Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing Reviewed

    Eiji Iwama, Kazuko Sakai, Koichi Azuma, Daijiro Harada, Kaname Nosaki, Katsuyuki Hotta, Makoto Nishio, Takayasu Kurata, Tatsuro Fukuhara, Hiroaki Akamatsu, Koichi Goto, Takayuki Shimose, Junji Kishimoto, Yoichi Nakanishi, Kazuto Nishio, Isamu Okamoto

    Cancer Science   109 ( 12 )   3921 - 3933   2018.12

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    DOI: 10.1111/cas.13820

  • Blood biomarkers of Hikikomori, a severe social withdrawal syndrome Reviewed

    Kohei Hayakawa, Takahiro Kato, Motoki Watabe, Alan R. Teo, Hideki Horikawa, Nobuki Kuwano, Norihiro Shimokawa, Mina Sato-Kasai, Hiroaki Kubo, Masahiro Ohgidani, Noriaki Sagata, Hiroyuki Toda, Masaru Tateno, Naotaka Shinfuku, Junji Kishimoto, Shigenobu Kanba

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-21260-w

  • A rightward saccade to an unexpected stimulus as a marker for lateralised visuospatial attention /631/378/2649/1310 /631/378/2617/1795 /631/477/2811 article Reviewed

    Masafumi Sanefuji, Hiroshi Yamashita, Michiko Torio, Daisuke Katsuki, Satoshi Akamine, Yoshito Ishizaki, Junji Kishimoto, Yasunari Sakai, Hidetoshi Takada, Keiko Yoshida, Shoichi Ohga

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-25890-y

  • Phase I/II study of carboplatin plus nab-paclitaxel and concurrent radiotherapy for patients with locally advanced non–small cell lung cancer Reviewed

    125   136 - 141   2018.11

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    Objectives: Chemoradiation regimens of greater efficacy are needed for patients with locally advanced non–small cell lung cancer (NSCLC). Patients and methods: In a phase I study, escalating doses of weekly nab-paclitaxel (40 or 50 mg/m
    2
    ) were administered along with weekly carboplatin at an area under the curve (AUC) of 2 mg mL
    –1
    min and concurrent radiotherapy with 60 Gy in 30 fractions to patients with locally advanced NSCLC. This concurrent phase was followed by a consolidation phase consisting of two 3-week cycles of nab-paclitaxel plus carboplatin. In a phase II study, nab-paclitaxel was administered at the recommended dose (RD) together with carboplatin and radiation. Results: In the phase I study, one of six patients experienced dose-limiting toxicity (leukopenia of grade 3 requiring a second consecutive skip in the administration of weekly chemotherapy) with nab-paclitaxel at 50 mg/m
    2
    , which was therefore determined to be the RD. Fifty-six patients treated at the RD were evaluable for safety and efficacy. Common toxicities of grade 3 or 4 in the concurrent phase included leukopenia (60.7%) and neutropenia (28.6%). No treatment-related deaths occurred during the study period. The objective response rate was 76.8% (95% confidence interval [CI], 64.2–85.9%), median progression-free survival was 11.8 months (60% CI, 10.6–16.2 months; 95% CI, 8.2–20.8 months), and median overall survival was not reached. Conclusion: Our results reveal encouraging feasibility and activity for concurrent chemoradiation with nab-paclitaxel at 50 mg/m
    2
    and carboplatin at an AUC of 2 in patients with locally advanced NSCLC.

    DOI: 10.1016/j.lungcan.2018.09.014

  • Nab-paclitaxel maintenance therapy following carboplatin + nab-paclitaxel combination therapy in chemotherapy naïve patients with advanced non-small cell lung cancer multicenter, open-label, single-arm phase II trial Reviewed

    36 ( 5 )   903 - 910   2018.10

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    Background A global multicenter study demonstrated superiority of carboplatin + nab-paclitaxel (PTX) therapy compared to carboplatin + PTX in terms of response rate (RR) and non-inferiority in terms of progression free survival (PFS) and overall survival (OS) in untreated patients with stage IIIB/IV non-small cell lung cancer; no clinical findings have so far been reported on maintenance therapies with nab-PTX. The aim of this study was to determine the efficacy and safety of maintenance therapy with nab-PTX following carboplatin + nab-PTX combination therapy. Methods Carboplatin (AUC 6) was administered on Day 1; and nab-PTX 100 mg/m2 on Days 1, 8, and 15, and dosing was repeated in 4 courses of 4 weeks each. In patients with clinical response was observed at the end of the 4th course, nab-PTX maintenance therapy was repeated. Results Out of 39 patients included in the efficacy analysis, 19 (48.7%) patients completed the induction therapy and 15 (38.5%) were transitioned to maintenance therapy. The median PFS in the maintenance phase was 6.5 (90%CI 1.4–11.4) months. The median OS in 15 patients was 12.6 (95%CI: 7.4-not reached). Grade ≥ 3 toxicities observed in more than 5% of patients were neutropenia (55.0%), anemia (15.0%), and febrile neutropenia (5.0%), with no increase during the maintenance phase. Conclusions Although statistically significance was not demonstrated presumably due to a limited transition rate from induction to maintenance phase, nab-PTX was suggested to be a useful treatment option following the induction therapy with nab-PTX in patients with advanced NSCLC.

    DOI: 10.1007/s10637-018-0617-6

  • Postmortem interval estimation using the animal model of postmortem gas volume changes Reviewed

    Chika Iwamoto, Kenoki Ouchida, Miki Okumura, Yosuke Usumoto, Junji Kishimoto, Masaharu Murata, Noriaki Ikeda, Makoto Hashizume

    Legal Medicine   32   66 - 70   2018.5

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    DOI: 10.1016/j.legalmed.2017.12.010

  • Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder An exploratory pilot case-control study Reviewed

    231   74 - 82   2018.4

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    Background: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. Methods: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis. Results: Plasma tryptophan and kynurenine levels were significantly lower in MDD group (N = 15) compared to healthy controls (HC) group (N = 19), and plasma tryptophan was the significant biomarker to identify MDD group (area under the curve = 0.740). Lower serum high density lipoprotein-cholesterol (HDL-C) was the predictive biomarker for severity of depression in MDD group (R2 = 0.444). Interestingly, depressive symptoms were variously correlated with plasma tryptophan-kynurenine and lipid related metabolites. Moreover, plasma tryptophan-kynurenine metabolites and cholesteryl esters (CEs) were significantly correlated in MDD group, but not in HC group. Limitations: This study had small sample size, and we did not use the multiple test correction. Conclusions: This is the first study to suggest that not only tryptophan-kynurenine metabolites but also HDL-C and CEs are important blood biomarkers for first-episode drug-naïve MDD patients. The present study sheds new light on early intervention in clinical practice in depression, and further clinical studies especially large-scale prospective studies are warranted.

    DOI: 10.1016/j.jad.2018.01.014

  • Treatment Rationale and Design for J-SONIC A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non–Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis Reviewed

    19 ( 1 )   e5 - e9   2018.1

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    We describe the treatment rationale and procedure for a randomized study (J-SONIC; University Hospital Medical Information Network Clinical Trials Registry identification no., UMIN000026799) of carboplatin plus nanoparticle albumin-bound paclitaxel (nab-paclitaxel) with or without nintedanib for patients with advanced non–small cell lung cancer (NSCLC) and idiopathic pulmonary fibrosis (IPF). The study was designed to examine the efficacy and safety of nintedanib administered with carboplatin plus nab-paclitaxel versus carboplatin plus nab-paclitaxel alone in chemotherapy-naive patients with advanced NSCLC associated with IPF. Eligible patients (enrollment target, n = 170) will be randomized at a 1:1 ratio to receive 4 cycles of carboplatin (area under the curve, 6 on day 1) plus nab-paclitaxel (100 mg/m
    2
    on days 1, 8, and 15) administered every 3 weeks either without (arm A) or with (arm B) nintedanib (150 mg twice daily), to be followed in arm B by single-agent administration of nintedanib (150 mg twice daily). The present trial is the first randomized controlled study for the treatment of NSCLC associated with IPF. The goal of the study is to demonstrate that nintedanib combined with carboplatin plus nab-paclitaxel prolongs the interval to acute exacerbation of IPF compared with carboplatin plus nab-paclitaxel alone.

    DOI: 10.1016/j.cllc.2017.06.003

  • Safety, tolerability, and pharmacokinetics of NK-104-NP a multicenter, randomized, placebo-controlled phase I investigator-initiated trial for intravenous administration of pitavastatin-loaded plga nanoparticles (Nk-104-NP) in healthy Japanese male subjects Reviewed

    Kaku Nakano, Tetsuya Matoba, Jun Ichiro Koga, Yushi Kashihara, Masato Fukae, Ichiro Ieiri, Masanari Shiramoto, Shin Irie, Junji Kishimoto, Koji Todaka, Kensuke Egashira

    International heart journal   59 ( 5 )   1015 - 1025   2018.1

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    DOI: 10.1536/ihj.17-555

  • A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors Reviewed

    Yasuki Hijikata, Toshihiko Okazaki, Yoshihiro Tanaka, Mutsunori Murahashi, Yuichi Yamada, Kazunari Yamada, Atsushi Takahashi, Hiroyuki Inoue, Junji Kishimoto, Yoichi Nakanishi, Yoshinao Oda, Yusuke Nakamura, Kenzaburo Tani

    PloS one   13 ( 1 )   2018.1

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    DOI: 10.1371/journal.pone.0187878

  • Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer Reviewed

    Kohei Otsubo, Kaname Nosaki, Chiyo K. Imamura, Hiroaki Ogata, Akitaka Fujita, Shinya Sakata, Fumihiko Hirai, Gouji Toyokawa, Eiji Iwama, Taishi Harada, Takashi Seto, Mitsuhiro Takenoyama, Takeshi Ozeki, Taisei Mushiroda, Mieko Inada, Junji Kishimoto, Kenji Tsuchihashi, Kentaro Suina, Osamu Nagano, Hideyuki Saya, Yoichi Nakanishi, Isamu Okamoto

    Cancer Science   108 ( 9 )   1843 - 1849   2017.9

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    DOI: 10.1111/cas.13309

  • Clarithromycin plus intravenous immunoglobulin therapy can reduce the relapse rate of Kawasaki disease A phase 2, open-label, randomized control study Reviewed

    Etsuro Nanishi, Hisanori Nishio, Hidetoshi Takada, Kenichiro Yamamura, Mitsuharu Fukazawa, Kenji Furuno, Yumi Mizuno, Kenjiro Saigo, Ryo Kadoya, Noriko Ohbuchi, Yasuhiro Onoe, Hironori Yamashita, Hideki Nakayama, Takuya Hara, Takuro Ohno, Yasuhiko Takahashi, Ken Hatae, Tatsuo Harada, Takayuki Shimose, Junji Kishimoto, Shoichi Ohga, Toshiro Hara

    Journal of the American Heart Association   6 ( 7 )   2017.7

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    DOI: 10.1161/JAHA.116.005370

  • Neurocognitive profile of euthymic Japanese patients with bipolar disorder Reviewed

    Nozomi Ishisaka, Satomi Shimano, Tomofumi Miura, Keisuke Motomura, Machiko Horii, Hisako Imanaga, Junji Kishimoto, Yasuhiro Kaneda, Ichiro Sora, Shigenobu Kanba

    Psychiatry and Clinical Neurosciences   71 ( 6 )   373 - 382   2017.6

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    DOI: 10.1111/pcn.12500

  • Longitudinal assessment of pain management with the pain management index in cancer outpatients receiving chemotherapy Reviewed

    Akiko Fujii, Yu Yamada, Koichi Takayama, Takako Nakano, Junji Kishimoto, Tatsuya Morita, Yoichi Nakanishi

    Supportive Care in Cancer   25 ( 3 )   925 - 932   2017.3

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    DOI: 10.1007/s00520-016-3482-x

  • Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting the CuVIC trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial Reviewed

    Susumu Takase, Tetsuya Matoba, Soichi Nakashiro, Yasushi Mukai, Shuujirou Inoue, Keiji Oi, Taiki Higo, Shunsuke Katsuki, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Mitsutaka Yamamoto, Makoto Usui, Kenji Sadamatsu, Shinji Satoh, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Kensuke Egashira, Kenji Sunagawa

    Arteriosclerosis, thrombosis, and vascular biology   37 ( 2 )   350 - 358   2017.2

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    DOI: 10.1161/ATVBAHA.116.308388

  • Early tumor shrinkage indicates a favorable response to bevacizumab-based first-line chemotherapy for metastatic colorectal cancer Reviewed

    Mamoru Ito, Hitoshi Kusaba, Satomi Mukaide, Junji Kishimoto, Hozumi Shimokawa, Shingo Tamura, Akitaka Makiyama, Gen Hirano, Hisanobu Oda, Tsuyoshi Shirakawa, Masato Komoda, Keita Uchino, Risa Tanaka, Kenji Mitsugi, Taito Esaki, Shuji Arita, hiroshi ariyama, Koichi Akashi, Eishi Baba

    Anti-cancer drugs   28 ( 10 )   1166 - 1173   2017.1

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    DOI: 10.1097/CAD.0000000000000562

  • Treatment Rationale and Design for J-AXEL A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer Reviewed

    18 ( 1 )   100 - 103   2017.1

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    Background Nanoparticle albumin-bound (nab) paclitaxel is a promising new therapeutic agent for all histologic types of non–small-cell lung cancer (NSCLC). We recently performed a phase 2 study of weekly nab-paclitaxel in patients with previously treated advanced NSCLC, finding promising activity and acceptable toxicity for this regimen. We have now designed a randomized phase 3 intergroup study (J-AXEL, UMIN000017487) to examine the clinical benefit and safety of nab-paclitaxel compared to docetaxel in patients with previously treated advanced NSCLC. Patients and Methods Patients are randomized to receive either docetaxel (60 mg/m2 on day 1 every 3 weeks, control arm) or nab-paclitaxel (100 mg/m2 on days 1, 8, and 15 every 3 weeks, experimental arm), with each drug being administered until disease progression or unacceptable toxicity. The study will evaluate the noninferiority of nab-paclitaxel relative to docetaxel for the primary end point of overall survival. Conclusion If the primary objective is achieved, this study will provide evidence for a new alternative treatment option for patients with previously treated advanced NSCLC.

    DOI: 10.1016/j.cllc.2016.08.003

  • The combination of PD-L1 expression and decreased tumorinfiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer Reviewed

    Hitomi Mori, Makoto Kubo, Rin Yamaguchi, Reiki Nishimura, Tomofumi Osako, Nobuyuki Arima, Yasuhiro Okumura, Masayuki Okido, Mai Yamada, Masaya Kai, Junji Kishimoto, Yoshinao Oda, Masafumi Nakamura

    Oncotarget   8 ( 9 )   15584 - 15592   2017.1

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    DOI: 10.18632/oncotarget.14698

  • Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations Reviewed

    Eiji Iwama, K. Sakai, K. Azuma, T. Harada, D. Harada, K. Nosaki, K. Hotta, F. Ohyanagi, T. Kurata, T. Fukuhara, H. Akamatsu, K. Goto, T. Shimose, Junji Kishimoto, Yoichi Nakanishi, K. Nishio, Isamu Okamoto

    Annals of Oncology   28 ( 1 )   136 - 141   2017.1

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    DOI: 10.1093/annonc/mdw531

  • Impact of Risk-Benefit Perception and Trust on Medical Technology Acceptance in Relation to Drug and Device Lag A Tripartite Cross-Sectional Survey Reviewed

    Koji Todaka, Junji Kishimoto, Masayuki Ikeda, Koji Ikeda, Haruko Yamamoto

    Therapeutic Innovation and Regulatory Science   52 ( 5 )   629 - 640   2017.1

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    DOI: 10.1177/2168479017739267

  • BRCAness as a biomarker for predicting prognosis and response to anthracycline-based adjuvant chemotherapy for patients with triple-negative breast cancer Reviewed

    Hitomi Mori, Makoto Kubo, Reiki Nishimura, Tomofumi Osako, Nobuyuki Arima, Yasuhiro Okumura, Masayuki Okido, Mai Yamada, Masaya Kai, Junji Kishimoto, Tetsuyuki Miyazaki, Yoshinao Oda, Takao Otsuka, Masafumi Nakamura

    PloS one   11 ( 12 )   2016.12

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    DOI: 10.1371/journal.pone.0167016

  • Prospective study of the UGT1A1*27 gene polymorphism during irinotecan therapy in patients with lung cancer Results of Lung Oncology Group in Kyusyu (LOGIK1004B) Reviewed

    Minoru Fukuda, Takayuki Suetsugu, Midori Shimada, Takeshi Kitazaki, Kohji Hashiguchi, Junji Kishimoto, Taishi Harada, Takashi Seto, Noriyuki Ebi, Koichi Takayama, Kenji Sugio, Hiroshi Semba, Yoichi Nakanishi, Yukito Ichinose

    Thoracic Cancer   7 ( 4 )   467 - 472   2016.7

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    DOI: 10.1111/1759-7714.12360

  • Sequential morphological change of Chiari malformation type II following surgical repair of myelomeningocele Reviewed

    Kimiaki Hashiguchi, Takato Morioka, Nobuya Murakami, Osamu Togao, Hiwatashi Akio, Masayuki Ochiai, Goki Eriguchi, Junji Kishimoto, Koji Iihara

    Child's Nervous System   32 ( 6 )   1069 - 1078   2016.6

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    DOI: 10.1007/s00381-016-3041-2

  • Phase II trial of erlotinib in elderly patients with previously treated non-small cell lung cancer Results of the lung oncology group in kyushu (LOGiK-0802) Reviewed

    Kazuhiko Yamada, Koichi Azuma, Masafumi Takeshita, Junji Uchino, Chinatsu Nishida, Takayuki Suetsugu, Akira Kondo, Taishi Harada, Hirofumi Eida, Junji Kishimoto, Goki Eriguchi, Koichi Takayama, Yoichi Nakanishi, Kenji Sugio

    Anticancer research   36 ( 6 )   2881 - 2887   2016.6

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  • Efficacy and Safety of A0001 (Brilliant Blue G250) for Internal Limiting Membrane Staining and Peeling Phase III Investigator-initiated Multicenter Clinical Trial Reviewed

    Hiroshi Enaida, Akito Hirakata, Masahito Ohji, Kohji Nishida, Toshiaki Kubota, Nahoko Ogata, Kohei Sonoda, Makiko Uchiyama, Junji Kishimoto, Koji Todaka, Yoichi Nakanishi, Tatsuro Ishibashi

    Nippon Ganka Gakkai zasshi   120 ( 6 )   439 - 448   2016.6

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  • Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors Reviewed

    Mutsunori Murahashi, Yasuki Hijikata, Kazunari Yamada, Yoshihiro Tanaka, Junji Kishimoto, Hiroyuki Inoue, Tomotoshi Marumoto, Atsushi Takahashi, Toshihiko Okazaki, Kazuyoshi Takeda, Masakazu Hirakawa, Hiroshi Fujii, Shinji Okano, Masaru Morita, Eishi Baba, Kazuhiro Mizumoto, Yoshihiko Maehara, Masao Tanaka, Koichi Akashi, Yoichi Nakanishi, Koji Yoshida, Takuya Tsunoda, Kazuo Tamura, Yusuke Nakamura, Kenzaburo Tani

    Clinical Immunology   166-167   48 - 58   2016.5

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    DOI: 10.1016/j.clim.2016.03.015

  • The efficacy and safety of cefepime or meropenem in the treatment of febrile neutropenia in patients with lung cancer. A randomized phase II study Reviewed

    , Masaki Fujita, Takemasa Matsumoto, Yuuichi Inoue, Hiroshi Wataya, Koichi Takayama, Masayuki Ishida, Noriyuki Ebi, Junji Kishimoto, Yukito Ichinose

    Journal of Infection and Chemotherapy   22 ( 4 )   235 - 239   2016.4

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    DOI: 10.1016/j.jiac.2016.01.005

  • Gefitinib Combined with Standard Chemoradiotherapy in EGFR-Mutant Locally Advanced Non-Small-Cell Lung Cancer The LOGIK0902/OLCSG0905 Intergroup Study Protocol Reviewed

    Katsuyuki Hotta, Jiichiro Sasaki, Sho Saeki, Nagio Takigawa, Kuniaki Katsui, Koichi Takayama, Naoyuki Nogami, Yoshiyuki Shioyama, Akihiro Bessho, Junji Kishimoto, Mitsune Tanimoto, Katsuyuki Kiura, Yukito Ichinose

    Clinical Lung Cancer   17 ( 1 )   75 - 79   2016.1

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    DOI: 10.1016/j.cllc.2015.08.004

  • Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer Reviewed

    Koichi Takayama, Shunichi Sugawara, Yasuo Saijo, Makoto Maemondo, Atsushi Sato, Shinzo Takamori, Taishi Harada, Tetsuro Sasada, Tatsuyuki Kakuma, Junji Kishimoto, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Yoichi Nakanishi

    Journal of Immunology Research   2016   2016.1

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    DOI: 10.1155/2016/1745108

  • Prevalence of dyslipidemia in Japanese patients with rheumatoid arthritis and effects of atorvastatin treatment Reviewed

    Mio Akiyama, Taro Mawatari, Yasuharu Nakashima, Hisaaki Miyahara, Hisakata Yamada, Ken Okazaki, Jun-Ichi Fukushi, Masakazu Kondo, Junji Kishimoto, Chinami Hashimura, Yukihide Iwamoto

    Clinical Rheumatology   34 ( 11 )   1867 - 1875   2015.8

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    DOI: 10.1007/s10067-015-3049-0

  • 3D MR Sequence Capable of Simultaneous Image Acquisitions with and without Blood Vessel Suppression Utility in Diagnosing Brain Metastases Reviewed

    kazufumi kikuchi, Hiwatashi Akio, Osamu Togao, Koji Yamashita, Masami Yoneyama, Makoto Obara, Junji Kishimoto, Takashi Yoshiura, Hiroshi Honda

    European Radiology   25 ( 4 )   901 - 910   2015.3

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    DOI: 10.1007/s00330-014-3496-z

  • Neural substrates of species-dependent visual processing of faces Use of morphed faces Reviewed

    Emi Yamada, Katsuya Ogata, Junji Kishimoto, Mutsuhide Tanaka, Tomokazu Urakawa, Takao Yamasaki, Shozo Tobimatsu

    Physiological Reports   3 ( 5 )   2015.1

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    DOI: 10.14814/phy2.12387

  • Highly sensitive and quantitative evaluation of the EGFR T790M mutation by nanofluidic digital PCR Reviewed

    Eiji Iwama, Koichi Takayama, Taishi Harada, Isamu Okamoto, Fumihiko Ookubo, Junji Kishimoto, Eishi Baba, Yoshinao Oda, Yoichi Nakanishi

    Oncotarget   6 ( 24 )   20466 - 20473   2015.1

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    DOI: 10.18632/oncotarget.4058

  • Performance of gadoxetic acid-enhanced MRI for detecting hepatocellular carcinoma in recipients of living-related-liver-transplantation Comparison with dynamic multidetector row computed tomography and angiography-assisted computed tomography Reviewed

    Daisuke Kakihara, Akihiro Nishie, Noboru Harada, Ken Shirabe, Tsuyoshi Tajima, Yoshiki Asayama, Kosei Ishigami, Tomohiro Nakayama, Yukihisa Takayama, Daisuke Okamoto, nobuhiro fujita, Junji Kishimoto, Hiroshi Honda

    Journal of Magnetic Resonance Imaging   40 ( 5 )   1112 - 1120   2014.11

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    DOI: 10.1002/jmri.24454

  • Urinary neutrophil gelatinase-associated lipocalin A useful biomarker for tacrolimus-induced acute kidney injury in liver transplant patients Reviewed

    Ayami Tsuchimoto, Haruka Shinke, Miwa Uesugi, Mio Kikuchi, Emina Hashimoto, Tomoko Sato, Yasuhiro Ogura, Koichiro Hata, Yasuhiro Fujimoto, Toshimi Kaido, Junji Kishimoto, Motoko Yanagita, Kazuo Matsubara, Shinji Uemoto, Satohiro Masuda

    PloS one   9 ( 10 )   2014.10

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    DOI: 10.1371/journal.pone.0110527

  • A feasibility trial of postoperative adjuvant chemotherapy with S-1, an oral fluoropyrimidine, for elderly patients with non-small cell lung cancer A report of the Lung Oncology Group in Kyushu (LOGIK) protocol 0901 Reviewed

    Riichiroh Maruyama, Noriyuki Ebi, Junji Kishimoto, Masato Kato, Tokujiro Yano, Yoshinori Nagamatsu, Shuichi Tsukamoto, Shinji Akamine, Sho Saeki, Yukito Ichinose

    International Journal of Clinical Oncology   19 ( 1 )   57 - 62   2014.2

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    DOI: 10.1007/s10147-013-0516-y

  • Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans Reviewed

    Kazu Kobayakawa, Hiromi Kumamaru, Hirokazu Saiwai, Kensuke Kubota, Yasuyuki Ohkawa, Junji Kishimoto, Kazuya Yokota, Ryosuke Ideta, Keiichiro Shiba, Hidetoshi Saitoh, Kazuhide Inoue, Yukihide Iwamoto, Seiji Okada

    Science Translational Medicine   6 ( 256 )   2014.1

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    DOI: 10.1126/scitranslmed.3009430

  • Can intensive lipid-lowering therapy improve the carotid Intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease? The JART and JART extension subanalysis Reviewed

    Hiroyuki Daida, Ryuji Nohara, Mitsumasa Hata, Kohei Kaku, Ryuzo Kawamori, Junji Kishimoto, Masahiko Kurabayashi, Izuru Masuda, Ichiro Sakuma, Tsutomu Yamazaki, Hiroyoshi Yokoi, Masayuki Yoshida

    Journal of atherosclerosis and thrombosis   21 ( 7 )   739 - 754   2014.1

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    DOI: 10.5551/jat.19109

  • The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment Reviewed

    Chika Iwamoto, Katsuto Takenaka, Shingo Urata, takuji yamauchi, Takahiro Shima, Takuro Kuriyama, Shinya Daitoku, Yasuyuki Saito, Toshihiro Miyamoto, Hiromi Iwasaki, Issay Kitabayashi, Katsuhiko Itoh, Junji Kishimoto, Daisuke Kohda, Takashi Matozaki, Koichi Akashi

    Experimental Hematology   42 ( 3 )   163 - 171.e1   2014.1

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    DOI: 10.1016/j.exphem.2013.11.005

  • Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy A multicenter analysis Reviewed

    Masanori Kobayashi, Shigetaka Shimodaira, Kazuhiro Nagai, Masahiro Ogasawara, Hidenori Takahashi, Hirofumi Abe, Mitsugu Tanii, Masato Okamoto, Sun Ichi Tsujitani, Seiichi Yusa, Takefumi Ishidao, Junji Kishimoto, Yuta Shibamoto, Masaki Nagaya, Yoshikazu Yonemitsu

    Cancer Immunology, Immunotherapy   63 ( 8 )   797 - 806   2014.1

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    DOI: 10.1007/s00262-014-1554-7

  • Close correlation between CXCR4 and VEGF expression and frequent CXCR7 expression in rhabdomyosarcoma Reviewed

    kina miyoshi, Kenichi Kouhashi, Fumiyoshi Fushimi, Hidetaka Yamamoto, Junji Kishimoto, Tomoaki Taguchi, Yukihide Iwamoto, Yoshinao Oda

    Human Pathology   45 ( 9 )   1900 - 1909   2014.1

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    DOI: 10.1016/j.humpath.2014.05.012

  • Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin subanalysis of the JART study Reviewed

    Hiroyoshi Yokoi, Ryuji Nohara, Hiroyuki Daida, Mitsumasa Hata, Kohei Kaku, Ryuzo Kawamori, Junji Kishimoto, Masahiko Kurabayashi, Izuru Masuda, Ichiro Sakuma, Tsutomu Yamazaki, Masayuki Yoshida

    International heart journal   55 ( 2 )   146 - 152   2014.1

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    DOI: 10.1536/ihj.13-216

  • Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling Reviewed

    Jiro Ikeda, Toshihiro Ichiki, Hirohide Matsuura, E. Inoue Eriko, Junji Kishimoto, Aya Watanabe, Chikahiro Sankoda, Shiro Kitamoto, Tomotake Tokunou, Kotaro Takeda, Guo Hua Fong, Kenji Sunagawa

    Journal of the American Heart Association   2 ( 3 )   2013.9

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    DOI: 10.1161/JAHA.113.000174

  • The reliability and validity of a newly developed scale for measuring a negative cognition towards diabetes Reviewed

    Masato Takii, Yasuko Uchigata, Junji Kishimoto, Akira Okada, Masahiro Matsumoto, Chihiro Morita, Tomokazu Hata, Takehiro Nozaki, Keisuke Kawai, Nobuyuki Sudo

    Journal of the Japan Diabetes Society   56 ( 8 )   560 - 569   2013.8

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  • Altered visual information processing systems in bipolar disorder Evidence from visual MMN and P3 Reviewed

    Toshihiko Maekawa, Satomi Katsuki, Junji Kishimoto, Toshiaki Onitsuka, Katsuya Ogata, Takao Yamasaki, Takefumi Ueno, Shozo Tobimatsu, Shigenobu Kanba

    Frontiers in Human Neuroscience   ( JUL )   2013.7

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    DOI: 10.3389/fnhum.2013.00403

  • Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. Reviewed

    Jiro Ikeda, Toshihiro Ichiki, Hirohide Matsuura, Eriko Inoue, Junji Kishimoto, Aya Watanabe, Chikahiro Sankoda, Shiro Kitamoto, Tomotake Tokunou, Kotaro Takeda, Guo Hua Fong, Kenji Sunagawa

    Journal of the American Heart Association   2 ( 3 )   2013.6

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  • Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell lung cancer harboring EGFR mutations Results of lung oncology group in Kyushu (LOGiK0803) Reviewed

    Kazuhiko Yamada, Koichi Takayama, Satoru Kawakami, Kouichi Saruwatari, Ryotaro Morinaga, Taishi Harada, Naoko Aragane, Shuya Nagata, Junji Kishimoto, Yoichi Nakanishi, Yukito Ichinose

    Japanese journal of clinical oncology   43 ( 6 )   629 - 635   2013.6

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    DOI: 10.1093/jjco/hyt056

  • Effect of long-term intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness Justification for atherosclerosis regression treatment (JART) extension study Reviewed

    Ryuji Nohara, Hiroyuki Daida, Mitsumasa Hata, Kohei Kaku, Ryuzo Kawamori, Junji Kishimoto, Masahiko Kurabayashi, Izuru Masuda, Ichiro Sakuma, Tsutomu Yamazaki, Hiroyoshi Yokoi, Masayuki Yoshida

    Circulation Journal   77 ( 6 )   1526 - 1533   2013.5

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    DOI: 10.1253/circj.CJ-12-1149

  • Impact of dendritic cell vaccines pulsed with Wilms' tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers Reviewed

    Hidenori Takahashi, Masato Okamoto, Shigetaka Shimodaira, Shun Ichi Tsujitani, Masaki Nagaya, Takefumi Ishidao, Junji Kishimoto, Yoshikazu Yonemitsu

    European Journal of Cancer   49 ( 4 )   852 - 859   2013.3

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    DOI: 10.1016/j.ejca.2012.11.005

  • Intensive lipid-lowering therapy for slowing progression as well as inducing regression of atherosclerosis in Japanese patients Subanalysis of the JART study Reviewed

    Tsutomu Yamazaki, Ryuji Nohara, Hiroyuki Daida, Mitsumasa Hata, Kohei Kaku, Ryuzo Kawamori, Junji Kishimoto, Masahiko Kurabayashi, Izuru Masuda, Ichiro Sakuma, Hiroyoshi Yokoi, Masayuki Yoshida

    International Heart Journal   54 ( 1 )   33 - 39   2013.2

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    DOI: 10.1536/ihj.54.33

  • Pitavastatin-incorporated nanoparticle-eluting stents attenuate in-stent stenosis without delayed endothelial healing effects in a porcine coronary artery model Reviewed

    Noriaki Tsukie, Kaku Nakano, Tetsuya Matoba, Seigo Masuda, Eiko Iwata, Miho Miyagawa, Gang Zhao, Wei Meng, Junji Kishimoto, Kenji Sunagawa, Kensuke Egashira

    Journal of Atherosclerosis and Thrombosis   20 ( 1 )   32 - 45   2013.2

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    DOI: 10.5551/jat.13862

  • Phase i study of bevacizumab combined with irinotecan and S-1 as second-line chemotherapy in patients with advanced colorectal cancer Reviewed

    Hitoshi Kusaba, Taito Esaki, Junji Kishimoto, Keita Uchino, Shuji Arita, Hozumi Kumagai, Kenji Mitsugi, Koichi Akashi, Eishi Baba

    Cancer chemotherapy and pharmacology   71 ( 1 )   29 - 34   2013.1

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    DOI: 10.1007/s00280-012-2023-7

  • Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis Reviewed

    Takuro Kuriyama, Katsuto Takenaka, Kentaro Kohno, takuji yamauchi, Shinya Daitoku, Goichi Yoshimoto, Yoshikane Kikushige, Junji Kishimoto, Yasunobu Abe, Naoki Harada, Toshihiro Miyamoto, Hiromi Iwasaki, Takanori Teshima, Koichi Akashi

    Blood   120 ( 19 )   4058 - 4067   2012.11

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    DOI: 10.1182/blood-2012-02-408864

  • Short circuit in deep brain stimulation Reviewed

    Kazuhiro Samura, Yasushi Miyagi, Tsuyoshi Okamoto, Takehito Hayami, Junji Kishimoto, Mitsuo Katano, Kazufumi Kamikaseda

    Journal of Neurosurgery   117 ( 5 )   955 - 961   2012.11

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    DOI: 10.3171/2012.8.JNS112073

  • Management of home blood pressure by amlodipine combined with angiotensin II receptor blocker in type 2 diabetes Reviewed

    Katsumi Miyauchi, Tsutomu Yamazaki, Hirotaka Watada, Yasushi Tanaka, Ryuzo Kawamori, Yutaka Imai, Shunya Ikeda, Akira Kitagawa, Yasuhiro Ono, Fumio Murayama, Jong Bock Choi, Satoru Suwa, Dobun Hayashi, Junji Kishimoto, Hiroyuki Daida

    Circulation Journal   76 ( 9 )   2159 - 2166   2012.9

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    DOI: 10.1253/circj.CJ-11-1406

  • Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation Validity of portal phase imaging for predicting tumor grade Reviewed

    Daisuke Okamoto, Kengo Yoshimitsu, Akihiro Nishie, Tsuyoshi Tajima, Yoshiki Asayama, Kosei Ishigami, Masakazu Hirakawa, yasuhiro ushijima, Daisuke Kakihara, Tomohiro Nakayama, Yunosuke Nishihara, Shinichi Aishima, Akinobu Taketomi, Junji Kishimoto, Hiroshi Honda

    European Journal of Radiology   81 ( 6 )   1116 - 1121   2012.6

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    DOI: 10.1016/j.ejrad.2011.02.056

  • A nationwide random sampling survey of potential complicated grief in Japan Reviewed

    Yasunao Mizuno, Junji Kishimoto, Nozomu Asukai

    Death Studies   36 ( 5 )   447 - 461   2012.5

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    DOI: 10.1080/07481187.2011.553323

  • Management and Support of Clinical Trials in Clinical and Translational Research Center, Kyushu University Hospital Reviewed

    Yoichi Nakanishi, Junji Kishimoto

    Japanese Pharmacology and Therapeutics   40 ( SUPPL. 1 )   2012.3

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  • Effect of intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness in Japanese patients Reviewed

    Ryuji Nohara, Hiroyuki Daida, Mitsumasa Hata, Kohei Kaku, Ryuzo Kawamori, Junji Kishimoto, Masahiko Kurabayashi, Izuru Masuda, Ichiro Sakuma, Tsutomu Yamazaki, Hiroyoshi Yokoi, Masayuki Yoshida

    Circulation Journal   76 ( 1 )   221 - 229   2012.1

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    DOI: 10.1253/circj.CJ-11-0887

  • Japan Prevention Trial of Diabetes by Pitavastatin in Patients with Impaired Glucose Tolerance (the J-PREDICT study) Rationale, study design, and clinical characteristics of 1269 patients Reviewed

    Tsutomu Yamazaki, Junji Kishimoto, Chikako Ito, Mitsuhiko Noda, Masato Odawara, Yasuo Terauchi, Teruo Shiba, Hiroji Kitazato, Yasuhiko Iwamoto, Yasuo Akanuma, Takashi Kadowaki

    Diabetology International   2 ( 3 )   134 - 140   2011.10

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    DOI: 10.1007/s13340-011-0032-0

  • Design and rationale of Japanese evaluation between formula of azelnidipine and amlodipine add on olmesartan to get antialbuminuric effect study (J-FLAG) Evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria Reviewed

    Katsuyuki Ando, Masakazu Haneda, Sadayoshi Ito, Naoki Kashihara, Koichi Node, Masaomi Nangaku, Tatsuo Shimosawa, Junji Kishimoto, Toshiro Fujita

    Cardiovascular Drugs and Therapy   25 ( 4 )   341 - 347   2011.8

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    DOI: 10.1007/s10557-011-6309-5

  • Erratum Design and rationale of japanese evaluation between formula of azelnidipine and amlodipine add on olmesartan to get antialbuminuric effect study (J-FLAG) : Ion of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria (Cardiovascular Drugs and Therapy (2011) 25 (365366) DOI 10.1007/s10557-011-6309-5)) Reviewed

    Katsuyuki Ando, Masakazu Haneda, Sadayoshi Ito, Naoki Kashihara, Koichi Node, Masaomi Nangaku, Tatsuo Shimosawa, Junji Kishimoto, Toshiro Fujita

    Cardiovascular Drugs and Therapy   25 ( 4 )   365 - 366   2011.8

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    DOI: 10.1007/s10557-011-6315-7

  • The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients Reviewed

    Masato Takii, Yasuko Uchigata, Junji Kishimoto, Chihiro Morita, Tomokazu Hata, Takehiro Nozaki, Keisuke Kawai, Yasuhiko Iwamoto, Nobuyuki Sudo, Chiharu Kubo

    Pediatric Diabetes   12 ( 4 PART 2 )   396 - 401   2011.6

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    DOI: 10.1111/j.1399-5448.2010.00708.x

  • The signal transducer and activator of transcription 5B gene polymorphism contributes to the cholesterol metabolism in Japanese children with growth hormone deficiency Reviewed

    Mika Makimura, Kenji Ihara, Kanako Kojima-Ishii, Takafumi Nozaki, Kazuhiro Ohkubo, Hitoshi Kohno, Junji Kishimoto, Toshiro Hara

    Clinical Endocrinology   74 ( 5 )   611 - 617   2011.5

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    DOI: 10.1111/j.1365-2265.2011.03980.x

  • Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion Reviewed

    Yoshitomo Maehata, Minako Hirahashi, Shinichi Aishima, Junji Kishimoto, Setsuo Hirohashi, Takashi Yao, Hiroshi Takashima, Masazumi Tsuneyoshi, Yoshinao Oda

    Human Pathology   42 ( 4 )   558 - 567   2011.4

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    DOI: 10.1016/j.humpath.2010.08.016

  • Ulcerative colitis-associated colorectal cancer shows a poorer survival than sporadic colorectal cancer A nationwide Japanese study Reviewed

    Toshiaki Watanabe, Tsuyoshi Konishi, Junji Kishimoto, Kenjiro Kotake, Tetsuichiro Muto, Kenichi Sugihara

    Inflammatory Bowel Diseases   17 ( 3 )   802 - 808   2011.3

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    DOI: 10.1002/ibd.21365

  • Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension Reviewed

    Ling Chen, Kaku Nakano, Satoshi Kimura, Tetsuya Matoba, Eiko Iwata, Miho Miyagawa, Hiroyuki Tsujimoto, Kazuhiro Nagaoka, Junji Kishimoto, Kenji Sunagawa, Kensuke Egashira

    Hypertension   57 ( 2 )   343 - 350   2011.2

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    DOI: 10.1161/HYPERTENSIONAHA.110.157032

  • Sessile serrated adenoma with early neoplastic progression A clinicopathologic and molecular study Reviewed

    Kohei Fujita, Hidetaka Yamamoto, Takayuki Matsumoto, Minako Hirahashi, Masaki Gushima, Junji Kishimoto, Ken Ichi Nishiyama, Tomoaki Taguchi, Takashi Yao, Yoshinao Oda

    American Journal of Surgical Pathology   35 ( 2 )   295 - 304   2011.2

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    DOI: 10.1097/PAS.0b013e318205df36

  • Expression and localization of E-cadherin and β-catenin in uterine carcinosarcoma Reviewed

    458 ( 1 )   85 - 94   2011.1

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    This study was designed to analyze the subcellular localization of E-cadherin and β-catenin both of which play a critical role in cell-cell adhesion in uterine carcinosarcoma (UCS). We performed an immunohistochemical reaction analysis of the subcellular localization of E-cadherin and β-catenin proteins in 46 cases of UCSs consisting of 28 UCSs with heterologous sarcoma and 18 UCSs with homologous sarcoma and compared their clinicopathological features. In most UCSs, membranous expression of E-cadherin and β-catenin was completely lost in sarcomatous components, but it was preserved in carcinomatous components. Nuclear β-catenin expression was observed significantly more frequently in sarcomatous components (31/46, 67.4%) than in carcinomatous components (22/46, 47.8%; P=0.0025). In sarcomatous components, nuclear β-catenin expression was found significantly more frequently in heterologous sarcoma (23/28, 82.1%) than in homologous sarcoma (8/18, 44.4%; P=0.0279). The stage was the only independent prognostic significant factor. These results suggest that reduced membranous expression of E-cadherin and β-catenin may contribute to the biphasic morphology of UCS. Furthermore, although the precise mechanism is unclear, nuclear β-catenin expression in sarcomatous components may also be associated with biphasic morphology and heterologous sarcomatous differentiation.

    DOI: 10.1007/s00428-010-1002-9

  • Efficacy of exposure therapy for Japanese patients with posttraumatic stress disorder due to mixed traumatic events A randomized controlled study Reviewed

    Nozomu Asukai, Azusa Saito, Nobuko Tsuruta, Junji Kishimoto, Toru Nishikawa

    Journal of Traumatic Stress   23 ( 6 )   744 - 750   2010.12

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    DOI: 10.1002/jts.20589

  • Mucin core protein expression in serrated polyps of the large intestine Reviewed

    Kohei Fujita, Minako Hirahashi, Hidetaka Yamamoto, Takayuki Matsumoto, Masaki Gushima, Yoshinao Oda, Junji Kishimoto, Takashi Yao, Mitsuo Iida, Masazumi Tsuneyoshi

    Virchows Archiv   457 ( 4 )   443 - 449   2010.10

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    DOI: 10.1007/s00428-010-0959-8

  • JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation Research paper Reviewed

    Seido Oku, Katsuto Takenaka, Takuro Kuriyama, Kotaro Shide, Takashi Kumano, Yoshikane Kikushige, Shingo Urata, takuji yamauchi, Chika Iwamoto, Haruko K. Shimoda, Toshihiro Miyamoto, Koji Nagafuji, Junji Kishimoto, Kazuya Shimoda, Koichi Akashi

    British Journal of Haematology   150 ( 3 )   334 - 344   2010.8

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    DOI: 10.1111/j.1365-2141.2010.08249.x

  • Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in japanese patients? - Rationale and design of the JART study Reviewed

    Masahiko Kurabayashi, Ichiro Sakuma, Ryuzo Kawamori, Hiroyuki Daida, Tsutomu Yamazaki, Masayuki Yoshida, Mitsumasa Hata, Izuru Masuda, Kohei Kaku, Hiroyoshi Yokoi, Junji Kishimoto, Ryuji Nohara

    Journal of atherosclerosis and thrombosis   17 ( 4 )   416 - 422   2010.1

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    DOI: 10.5551/jat.2899

  • Morning home blood pressure may be a significant marker of nephropathy in Japanese patients with type 2 diabetes ADVANCED-J study 1 Reviewed

    Yasushi Tanaka, Hiroyuki Daida, Yutaka Imai, Katsumi Miyauchi, Yasukazu Sato, Masao Hiwatari, Akira Kitagawa, Junji Kishimoto, Tsutomu Yamazaki, Ryuzo Kawamori

    Hypertension Research   32 ( 9 )   770 - 774   2009.9

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    DOI: 10.1038/hr.2009.96

  • Subthalamic nucleus stimulation does not cause deterioration of preexisting hallucinations in Parkinson's disease patients Reviewed

    Fumiaki Yoshida, Yasushi Miyagi, Junji Kishimoto, Takato Morioka, Nobuya Murakami, Kimiaki Hashiguchi, Kazuhiro Samura, Nobutaka Sakae, Ryo Yamasaki, Minako Kawaguchi, Tomio Sasaki

    Stereotactic and Functional Neurosurgery   87 ( 1 )   45 - 49   2009.2

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    DOI: 10.1159/000195719

  • The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis Reviewed

    Ko Matsudaira, Atsushi Seichi, Junichi Kunogi, Takashi Yamazaki, Atsuki Kobayashi, Yorito Anamizu, Junji Kishimoto, Kazuto Hoshi, Katsushi Takeshita, Kozo Nakamura

    Spine   34 ( 2 )   115 - 120   2009.1

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    DOI: 10.1097/BRS.0b013e31818f924d

  • Pilot study on prolonged exposure of Japanese patients with posttraumatic stress disorder due to mixed traumatic events Reviewed

    Nozomu Asukai, Azusa Saito, Nobuko Tsuruta, Ritsuko Ogami, Junji Kishimoto

    Journal of Traumatic Stress   21 ( 3 )   340 - 343   2008.6

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    DOI: 10.1002/jts.20337

  • 日本語版PTSD症状評価尺度(PSSI-J)の信頼性と妥当性の検証 Reviewed

    藤澤大介、石井朝子、岸本淳司、エドナ B. フォア

    臨床精神医学   2008.1

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  • Breath-hold monitoring and visual feedback for radiotherapy using a charge-coupled device camera and a head-mounted display System development and feasibility Reviewed

    Tadamasa Yoshitake, Katsumasa Nakamura, Yoshiyuki Shioyama, Satoshi Nomoto, Ohga Saiji, Takashi Toba, Takehiro Shiinoki, Shigeo Anai, Hiromi Terashima, Junji Kishimoto, Hiroshi Honda

    Radiation Medicine - Medical Imaging and Radiation Oncology   26 ( 1 )   50 - 55   2008.1

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    DOI: 10.1007/s11604-007-0189-4

  • 腰部脊柱管狭窄症の実態 -症状の抑うつおよび健康関連QOLの関係- Reviewed

    松平浩、岸本淳司、原慶宏、森井太郎、星和人、中村耕三

    日本腰痛学会雑誌   2007.11

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  • Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes Reviewed

    Guangyao Liu, Hiroshi Kawaguchi, Toru Ogasawara, Yukiyo Asawa, Junji Kishimoto, Tsuguharu Takahashi, Ung Il Chung, Hisayo Yamaoka, Hirotaka Asato, Kozo Nakamura, Tsuyoshi Takato, Kazuto Hoshi

    Journal of Biological Chemistry   282 ( 28 )   20407 - 20415   2007.7

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    DOI: 10.1074/jbc.M608383200

  • Prognosis and risk factors of metastasis in colorectal carcinoids Results of a nationwide registry over 15 years Reviewed

    Tsuyoshi Konishi, Toshiaki Watanabe, Junji Kishimoto, Kenjiro Kotake, Tetsuichiro Muto, Hirokazu Nagawa

    Gut   56 ( 6 )   863 - 868   2007.6

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    DOI: 10.1136/gut.2006.109157

  • Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction. Reviewed International journal

    Osada A, Iwabuchi T, Kishimoto J, Hamazaki TS, Okochi H.

    Tissue Engineering   2007.5

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  • ドメスティックバイオレンス被害児童の暴力の実態と精神健康 Reviewed

    永末貴子、石井朝子、木村弓子、黒崎美智子、村上由佳、岸本淳司

    ストレス科学   2007.3

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  • Radiosurgery to reduce the risk of first hemorrhage from brain arteriovenous malformations Reviewed

    Keisuke Maruyama, Masahiro Shin, Masao Tago, Junji Kishimoto, Akio Morita, Nobutaka Kawahara

    Neurosurgery   60 ( 3 )   453 - 458   2007.3

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    DOI: 10.1227/01.NEU.0000255341.03157.00

  • Reliability and Validity of a Japanese Version of the Yale Global Tic Severity Scale: A Preliminary Study Reviewed

    Kayo INOKO, Aya NISHIZONO-MAHER, Satoko TANI, Yukiko KANO, Junji KISHIMOTO, Norika HAYAKAWA, Shuji HONJO, Mari KASAHARA, Kazuhiko SAITO, Kayano ISHII, Makiko OSAWA

    Japanese Journal of Child and Adolescent Psychiatry   2006.12

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  • Elective colon and rectal surgery differ in risk factors for wound infection Results of prospective surveillance Reviewed

    Tsuyoshi Konishi, Toshiaki Watanabe, Junji Kishimoto, Hirokazu Nagawa

    Annals of Surgery   244 ( 5 )   758 - 763   2006.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.sla.0000219017.78611.49

  • Erratum Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes [Cell Transplantation 14, 9 [683-693]] Reviewed

    Tsuguharu Takahashi, Toru Ogasawara, Junji Kishimoto, Guangyao Liu, Hirotaka Asato, Takashi Nakatsuka, Eijyu Uchinuma, Kozo Nakamura, Hiroshi Kawaguchi, Ung Il Chung, Tsuyoshi Takato, Kazuto Hoshi

    Cell Transplantation   15 ( 4 )   2006.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Acute stress disorder and posttraumatic stress disorder symptoms among patients severely injured in motor vehicle accidents in Japan Reviewed

    Satoko Hamanaka, Nozomu Asukai, Yoshito Kamijo, Kotaro Hatta, Junji Kishimoto, Hitoshi Miyaoka

    General Hospital Psychiatry   28 ( 3 )   234 - 241   2006.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.genhosppsych.2006.02.007

  • Prospective surveillance effectively reduced rates of surgical site infection associated with elective colorectal surgery at a university hospital in Japan Reviewed

    Tsuyoshi Konishi, Toshiaki Watanabe, Keita Morikane, Kazuhiko Fukatsu, Joji Kitayama, Naoyuki Umetani, Junji Kishimoto, Hirokazu Nagawa

    Infection Control and Hospital Epidemiology   27 ( 5 )   526 - 528   2006.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1086/504444

  • Risk factors for anastomotic leakage after surgery for colorectal cancer Results of prospective surveillance Reviewed

    Tsuyoshi Konishi, Toshiaki Watanabe, Junji Kishimoto, Hirokazu Nagawa

    Journal of the American College of Surgeons   202 ( 3 )   439 - 444   2006.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jamcollsurg.2005.10.019

  • 海上保安官における惨事ストレスならびに惨事ストレスチェックリストの開発 Reviewed

    廣川進 飛鳥井望 岸本淳司

    トラウマティックストレス   2005.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Spinal stenosis in grade I degenerative lumbar spondylolisthesis A comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion Reviewed

    Ko Matsudaira, Takashi Yamazaki, Atsushi Seichi, Katsushi Takeshita, Kazuto Hoshi, Junji Kishimoto, Kozo Nakamura

    Journal of Orthopaedic Science   10 ( 3 )   270 - 276   2005.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00776-005-0887-7

  • The role of self-report questionnaire in the screening of postnatal depression - A community sample survey in central Tokyo Reviewed

    Aya Nishizono-Maher, Junji Kishimoto, Hiromichi Yoshida, Kyoko Urayama, Miki Miyato, Yuki Otsuka, Hiroko Matsui

    Social Psychiatry and Psychiatric Epidemiology   39 ( 3 )   185 - 190   2004.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00127-004-0727-7

  • シェルター入所者におけるドメスティックバイオレンス被害の実態と精神健康に及ぼす影響 Reviewed

    石井朝子 飛鳥井望 木村弓子 永末貴子 黒崎美智子 岸本淳司

    精神科治療学   2004.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • コメント:複合最大対比法を含む統計的検定の毒性試験への適用について Invited Reviewed

    岸本淳司

    計量生物学   2004.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • The Mental Influence of Sexual Trauma on Victims: From the Results of An Investigation of Female College Students in Japan Reviewed International journal

    Tomoko Ishii, Nozomu Asukai, Takako Konishi, Miwa Kojimoto, and Junji Kishimoto

    Family Violence & Sexual Assault Bulletin   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    The Mental Influence of Sexual Trauma on Victims: From the Results of An Investigation of Female College Students in Japan

  • ドメスティックバイオレンス(DV)簡易スクリーニング尺度(DVSI)の作成および信頼性・妥当性の検討 Reviewed

    石井朝子 飛鳥井望 木村弓子 永末貴子黒崎美智子 岸本淳司

    精神医学   2003.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

▼display all

Books

  • SASによる回帰分析

    芳賀敏郎 野沢昌弘 岸本淳司( Role: Joint author)

    東京大学出版会  1996.7 

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    Language:Japanese   Book type:Scholarly book

  • クォリティマネジメント用語辞典

    吉澤正(編集委員長)( Role: Joint author)

    日本規格協会  2004.5 

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    Language:Japanese   Book type:Scholarly book

  • SASによるデータ解析入門第2版

    市川真一 大橋靖雄 岸本淳司 浜田知久馬( Role: Joint author)

    東京大学出版会  1993.8 

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    Language:Japanese   Book type:Scholarly book

Presentations

  • ヒト関節軟骨細胞の表面マーカーと基質産生との相関解析

    浅輪幸世, 岸本淳司, 中川匠, 藤原夕子, 高戸毅, 星和人

    日本再生医療学会  2010.3 

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    Event date: 2010.3

    Presentation type:Oral presentation (general)  

    Venue:広島国際会議場   Country:Japan  

  • 整形外科臨床研究のデザインと統計<臨床研究の統計処理> Invited

    岸本 淳司

    日本整形外科学会  2009.5 

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    Event date: 2009.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • Increase ARB? or Conbine CCB?: Amlodipine Versus Angiotensine-II ReceptorBlocker, Control of Blood Pressure Evaluation Trial in Diabetics(ADVANCED-J STUDY) International conference

    Hiroyuki Daida, Ryuzo Kawamori, Yutaka Imai, Yasushi Tanaka, Katsumi Miyauchi,

    The 21st Scientific Meeting of the International Society of Hypertension  2006.10 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

    Increase ARB? or Conbine CCB?: Amlodipine Versus Angiotensine-II Receptor Blocker, Control of Blood Pressure Evaluation Trial in Diabetics(ADVANCED-J STUDY)

  • DAWN JAPAN Study 2005 (3) Comparison of Patients's Burden towards taking insulin treatment and its physician's estimate in Japanese patients with Type 2 Diabetes

    Yoichi Hayashi, Hitoshi Ishii, Shinichi Oikawa, Masato Odawara, Junji Kishimoto,

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    Presentation type:Oral presentation (general)  

    Country:Japan  

    DAWN JAPAN Study 2005 (3) Comparison of Patients's Burden towards taking insulin treatment and its physician's estimate in Japanese patients with Type 2 Diabetes

  • DAWN JAPAN Study 2005 (5) Changes in Attitude and Treatment Satisfaction after initiation of Insulin Treatment among Japanese Patients with Type 2 Diabetes

    Hiroaki Seino, Hitoshi Ishii, Shinichi Oikawa, Masato Odawara, Junji Kishimoto,

    2006.5 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

    DAWN JAPAN Study 2005 (5) Changes in Attitude and Treatment Satisfaction after initiation of Insulin Treatment among Japanese Patients with Type 2 Diabetes

  • DAWN JAPN study 2005 (4) Relationship between stage changes and initiation of insulin treatment for patients with Type 2 Diabetes

    Hirofumi Makino, Hitoshi Ishii, Sinichi Oikawa, Masato Odawara, Junji Kishimoto,

    2006.5 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

    DAWN JAPN study 2005 (4) Relationship between stage changes and initiation of insulin treatment for patients with Type 2 Diabetes

  • DAWN JAPAN study 2005 (2) Is Insulin therapy introduced to patients with Type 2 diabetes in a timely manner?

    Yasushi Saito, Hitoshi Ishii, Shinichi Oikawa, Masato Odawara, Junji Kishimoto,

    2006.5 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

    DAWN JAPAN study 2005 (2) Is Insulin therapy introduced to patients with Type 2 diabetes in a timely manner?

  • DAWN JAPAN Study 2005 (1) REALITY OF TREATMENT OF PATIENTS WITH TYPE 2 DIABETES IN JAPAN

    Masato Odawara, Hitoshi Ishii, Shinichi Oikawa, Junji Kishimoto, Yasushi Saito

    2006.5 

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    Presentation type:Oral presentation (general)  

    Country:Japan  

    DAWN JAPAN Study 2005 (1) REALITY OF TREATMENT OF PATIENTS WITH TYPE 2 DIABETES IN JAPAN

  • 網膜症合併2型糖尿病における心血管イベント一次予防に対する強化スタチン療法の有用性 血圧コントロール状況による影響

    池田 翔大, 篠原 啓介, 円山 信之, 松島 将士, 遠山 岳詩, 船越 公太, 岸本 淳司, 伊藤 裕, 小室 一成, 筒井 裕之

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集  2022.6  (NPO)日本高血圧学会

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    Language:Japanese  

  • 脳深部刺激療法を行うパーキンソン病患者のためのQoL評価尺度の開発

    川口 美奈子, 宮城 靖, 岸本 淳司, 左村 和宏, 徳永 豊, 渡利 茉里, 江口 弘子, 上田 真太郎, 重藤 寛史, 飯原 弘二, 吉本 幸司

    日本定位・機能神経外科学会プログラム・抄録集  2023.1  (一社)日本定位・機能神経外科学会

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  • 心電図における左室肥大は一般人口において将来の腎機能低下と関連する

    池田 翔大, 篠原 啓介, 田川 公士朗, 遠山 岳詩, 岸本 淳司, 外山 研介, 筒井 裕之, 絹川 真太郎

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 川崎病発症とワクチン接種 前向きケースコントロール研究を含む種々の比較研究

    村田 憲治, 小野山 さがの, 山村 健一郎, 水野 由美, 古野 憲司, 松原 啓太, 波多江 健, 益田 君教, 野村 裕一, 大野 拓郎, 絹巻 暁子, 三浦 大, 酒井 康成, 大賀 正一, 福島 若葉, 岸本 淳司, 中村 好一, 原 寿郎

    日本小児感染症学会総会・学術集会プログラム・抄録集  2022.11  (一社)日本小児感染症学会

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  • 呼吸器ウイルス感染と川崎病発症に関する分子疫学的検討

    丸山 健太朗, 村田 憲治, 水野 由美, 小野山 さがの, 保科 隆之, 山村 健一郎, 古野 憲司, 岸本 淳司, 楠原 浩一, 原 寿郎

    日本小児科学会雑誌  2024.2  (公社)日本小児科学会

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  • 合併症を伴う肺癌治療 特発性肺線維症合併進行非小細胞肺癌に対するニンテダニブ+化学療法と化学療法単独を比較するランダム化第3相試験(J-SONIC)

    田宮 基裕, 大坪 孝平, 岸本 淳司, 安藤 昌彦, 釼持 広知, 峯岸 裕司, 堀之内 秀仁, 加藤 晃史, 市原 英基, 近藤 征史, 安宅 信二, 山本 信之, 中川 和彦, 中西 洋一, 岡本 勇

    日本呼吸器学会誌  2022.4  (一社)日本呼吸器学会

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    Language:Japanese  

  • AIが変える循環器領域 ディープラーニングによる術後心房細動ハイリスク患者の検出(Deep Learning Approach to Detect the High-risk Patients of Postoperative Atrial Fibrillation)

    遠山 岳詩, Ide Tomomi, Ikeda Masataka, Nagata Takuya, Tagawa Koshiro, Hirose Masayuki, Funakoshi Kouta, Sakamoto Kazuo, Kishimoto Junji, Todaka Koji, Nakashima Naoki, Tsutsui Hiroyuki

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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    Language:English  

  • 有熱性尿路感染症罹患児での膀胱尿管逆流症予測スコアの構築

    黒川 麻里, 村田 憲治, 保科 隆之, 古野 憲司, 郭 義胤, 岸本 淳司, 大賀 正一

    日本小児科学会雑誌  2024.2  (公社)日本小児科学会

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  • 筋萎縮性側索硬化症における疾患進行速度の新しい定量的指標(A novel quantitative indicator for disease progression rate in amyotrophic lateral sclerosis)

    Kobayakawa Yuko, Todaka Koji, Hashimoto Yu, Ko Senri, Kishimoto Junji, Yamasaki Ryo, Isobe Noriko

    臨床神経学  2022.10  (一社)日本神経学会

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  • 統計解析の基礎と実践(傾向スコアマッチング)

    岸本 淳司, 田川 公士朗

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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    Language:Japanese  

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MISC

  • 診断法の性能評価としてのROC解析

    岸本 淳司

    2017.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    冠動脈の狭窄に対して経皮的冠動脈形成術(PCI)の適用を判断するための新しい方法にFFRCTがある。DISCOVER-FLOWは、FFRCTの診断能が従来の侵襲的な心筋血流予備量比(FFRCT)に十分近いことを示した研究である。これらの結果を用いてFFRCTは特許を取得し、プログラムでありながら医療機器としての承認を得、日本循環器学会も適正使用指針を出すに至った。本論では、DISCOVER-FLOWに用いられた診断能評価の統計的技法について解説する。

Professional Memberships

  • Biometric Society of Japan

  • Japanese Society of Applied Statistics

Committee Memberships

  • Executive   Domestic

    2015.4 - 2017.3   

  • Councilor   Domestic

    2003.4 - 2004.3   

  • 日本応用統計学会   学会誌編集委員   Domestic

    2001.4 - 2003.3   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Secretary International contribution

    East Asia Regional Biometric Conference 2015  ( Conference Hall, Kyushu University Station-I for Collaborative Research (2F), School of Medicine Japan ) 2015.12 - 2022.12

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    Type:Competition, symposium, etc. 

    Number of participants:175

Research Projects

  • レセプト情報のAI解析による認知症・フレイル関連事象のリスク因子解析

    Grant number:24K13323  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    半田 宣弘, 岸本 淳司, 光武 誠吾, 小原 道子

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    Grant type:Scientific research funding

    保険レセプトデータは検査結果や病気の重症度などの医療情報が乏しく、医学研究に適さないとされてきた。しかし、処方薬剤の情報、治療のイベント(手術治療、放射線治療等)や医療材料の使用歴の情報は完全に把握することができ、複数の医療機関のレセプトが統合され一元的に取り扱われている。後期高齢者のデータは悉皆性を持った情報である。本研究は北海道の後期高齢者のレセプトデータ(705538人)を用いて、高齢者の健康寿命延伸の障害となる1.認知症、2.転倒・骨折、3.誤嚥性肺炎、4.フレイルの進行、5.死亡などのリスク因子をAI技術・機械学習の技術を用いて同定し、リスクの軽減措置を検討することである。

    CiNii Research

  • Construction of an implementable CGA-utilizing support model to maintain and improve the quality of life of postoperative patients with rectal cancer.

    Grant number:23K27888  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant type:Scientific research funding

    CiNii Research

  • Challenges in Building a New Cancer Prevention Behavior Support Model: Exploring Approaches for Cancer Survivor Families

    Grant number:22K19689  2022 - 2027

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Challenging Research(Exploratory)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    CiNii Research

  • 実践的看護臨床薬理学教育モデル(iDrug)に基づいた新たな教育システムの開発

    Grant number:21H03223  2021 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Scientific research funding

  • 食道アカラシアの前駆状態とされる食道胃接合部通過障害に対する アコチアミドの有効性と安全性を検討する第II相医師主導治験

    Grant number:21443817  2021 - 2023

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • リパスジルを用いた未熟児網膜症に対する新規点眼薬の開発

    Grant number:20314729  2020 - 2022

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • レジストリを活用した慢性血栓塞栓性肺高血圧症に対するエドキサバンの適応拡大のための第Ⅲ相医師主導治験

    Grant number:20314174  2020 - 2022

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • シーズ開発実績に裏付けられたARO機能のリソース次元縮約と可視化に関する研究

    Grant number:20318154  2020

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • xploring the Factors for the Improvement of the screening rate for Colorectal Cancer among Japanese

    Grant number:19K22764  2019.6 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Knoshita Yumiko

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    Grant type:Scientific research funding

    1) JSTAR, Japan, HRS, USA, data comparison between Japan and the U.S.: Together with the University of Hawaii, we decided to analyze the data from the Japan-U.S. comparison regarding breast cancer screening examinations taken. In Japan and the U.S., 37% (N=653) and 73.4% (N=5177) of women underwent screening mammography, respectively. For the Japanese, older age and nonsmoking were associated with screening behavior. Americans had higher screening uptake among married women, nonsmokers, nondrinkers, active exercisers, and women who had dental examinations.
    2) Comparison between BRFSS (Japanese Americans) and Japanese (applicant survey), and 3) Analysis of factors influencing screening visits to patients with colorectal cancer has been delayed in implementation.

    CiNii Research

  • 日本人大腸がんスクリーニング検査受診率向上にむけた影響要因の探索

    Grant number:19156331  2019 - 2023

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 特発性肺線維症合併進行非小細胞肺癌に対する標準治療開発に関する研究

    Grant number:19188203  2019 - 2021

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • ナチュラルキラーT細胞活性化による慢性炎症制御に基づく新たな心筋症治療の実用化

    Grant number:18950046  2018 - 2020

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • ポジショニング分析および経験則分析によるARO機能類型化・評価指標創出のための調査研究

    Grant number:18089128  2018 - 2019

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • Brilliant Blue G250による水晶体前嚢可視化検討 第3相多施設共同医師主導治験

    Grant number:17933709  2017 - 2018

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 患者レジストリを活用した難治性クッシング症候群及びサブクリニカルクッシング症候群の病態解明と11β-HSD1阻害剤の臨床開発

    Grant number:16769685  2016 - 2018

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 高性能国産新規RNAウイルスベクターによる虚血肢治療製剤の開発

    Grant number:15652466  2015 - 2016

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 奨学寄付金

    2009

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    Grant type:Donation

  • 難治性心不全に対するPDE5阻害剤の効果を検証する無作為化比較試験の計画に対する研究

    Grant number:17010  2007

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 循環器疾患領域における大規模臨床試験の手法に係る研究

    Grant number:H18-特別-指定-010  2006 - 2007

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 虚血性心疾患のQOLに関する特別調査

    2005

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    Grant type:Donation

  • ドメスティック・バイオレンス被害が子どもの精神健康に及ぼす影響

    Grant number:16590530  2004 - 2005

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アンジオテンシンⅡ受容体拮抗薬(AⅡ拮抗薬)で降圧不十分な糖尿病を伴う高血圧症患者に対するカルシウム拮抗薬追加併用群とAⅡ拮抗薬増量群の無作為化割付比較試験(ADVANCED-J)

    2004

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    Grant type:Donation

  • 腰部脊柱管狭窄症患者のQOLに関する研究

    2004

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    Grant type:Donation

  • Study of Diabetic Atherosclerosis Prevention by Cilostazol(DAPC Study)

    2004

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    Grant type:Donation

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Educational Activities

  • Graduate School of Medical Sciences: Analysis of Clinical Research Data.
    School of Biomedical Science: Biomedical Seminar II
    School of Biomedical Science: Introduction to Biomedical Science II
    Graduate School of Systems Life Sciences: Clinical/Medical Engineering.
    Part-time lecturer of Biostatistics at the Union of Japanese Scientists and Engineers.

Class subject

  • トランスレーショナルリサーチの推進体制とその現状

    2024.10 - 2024.12   Fall quarter

  • 医療イノベーション ー未来の医療を一緒に作ろうー

    2024.10 - 2024.12   Fall quarter

  • 医薬品・医療機器開発と治験

    2024.6 - 2024.8   Summer quarter

  • トランスレーショナルリサーチの推進体制とその現状

    2022.10 - 2022.12   Fall quarter

  • 医療イノベーション ー未来の医療を一緒に作ろうー

    2022.10 - 2022.12   Fall quarter

  • 医薬品・医療機器開発と治験

    2022.6 - 2022.8   Summer quarter

  • トランスレーショナルリサーチの推進体制とその現状

    2021.10 - 2022.3   Second semester

  • 臨床試験方法論

    2018.10 - 2019.3   Second semester

  • 臨床研究データの解析

    2018.4 - 2018.9   First semester

  • 臨床試験方法論

    2017.10 - 2018.3   Second semester

  • 臨床研究データの解析

    2017.4 - 2017.9   First semester

  • 生命科学科:生命科学概論II

    2009.10 - 2010.3   Second semester

  • 生命科学科:総合生命科学セミナーII

    2009.10 - 2010.3   Second semester

  • 臨床・医用工学特論

    2009.10 - 2010.3   Second semester

  • 臨床研究データの解析

    2009.4 - 2009.9   First semester

  • 生命科学科:生命科学概論II

    2008.10 - 2009.3   Second semester

  • 生命科学科:総合生命科学セミナーII

    2008.10 - 2009.3   Second semester

  • 臨床・医用工学特論

    2008.10 - 2009.3   Second semester

  • 臨床研究データの解析

    2008.4 - 2008.9   First semester

  • 臨床研究データの解析

    2007.4 - 2007.9   First semester

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  香港理工大学(The Hong Kong Polytechnic University)  Classification:Affiliate faculty  Domestic/International Classification:Overseas 

    Semester, Day Time or Duration:2024年度3回訪問予定

  • 2006  東京大学 医学系研究科  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:集中講義

Other educational activity and Special note

  • 2020  Special Affairs 

     詳細を見る

    Thesis adviser in Graduate School of Nursing, University of Miyazaki

  • 2009  Special Affairs 

     詳細を見る

    Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers.

  • 2008  Special Affairs 

     詳細を見る

    Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers.

  • 2007  Special Affairs 

     詳細を見る

    Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers.

  • 2006  Special Affairs 

     詳細を見る

    Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers.