Updated on 2024/09/13

Information

 

写真a

 
IWASAKI TAKESHI
 
Organization
Kyushu University Hospital Division of Diagnostic Pathology Associate Professor
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Concurrent)
Title
Associate Professor
Tel
0926426061
Profile
【研究業績】 皮膚メルケル細胞癌、軟部肉腫に関する分子病理学研究に従事し、それらの研究成果を論文等に執筆する一方、外科病理の知識を生かし臨床医学・基礎医学研究室との協同研究も行っている。 【教育活動】 医学部学生の分子病理および外科病理の講義、病材示説、病理標本の実習を担当。医学研究院大学院生の分子病理学的解析法の教育も担当。 【社会連携活動】 地域の病院等の病理検査・診断を行い、外科病理の知識を地域に還元している。

Degree

  • MD. PhD

Research History

  • 2019年4月-2021年3月 独立行政法人 地域医療機能推進機構 九州病院

    2019年4月-2021年3月 独立行政法人 地域医療機能推進機構 九州病院

Education

  • Tottori University   Faculty of medicine

    2007.4 - 2013.3

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    Country: Japan

Research Interests・Research Keywords

  • Research theme:Bone and soft tissue sarcomas

    Keyword:Bone and soft tissue sarcomas

    Research period: 2021.4

  • Research theme:Merkel cell carcinoma

    Keyword:Merkel cell carcinoma

    Research period: 2010.4

Awards

  • 福岡県すこやか健康事業団 がん研究助成金 優秀賞

    2019.1   福岡県すこやか健康事業団  

  • 分子生物学会 優秀ポスター賞

    2016.12   分子生物学会  

  • 日本病理学会100周年記念病理学研究新人賞

    2016.5   日本病理学会  

  • 100周年記念病理学研究新人賞

    2016.5   日本病理学会   メルケル細胞癌の病態メカニズムの解明

  • European congress of pathology, the 2nd BEST poster prize

    2014.9   European congress of pathology  

Papers

  • Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma. Reviewed International journal

    Iwasaki T, Hayashi K, Matsushita M, Nonaka D, Matsumoto T, Taniguchi M, Kuwamoto S, Umekita Y, Oda Y.

    Scientific Reports   13 ( 1 )   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-40050-7.

  • Comparison of Akt/mammalian target of rapamycin/4E-binding protein 1 pathway signal activation in round stromal and surface cells in patients with sclerosing pneumocytoma Reviewed International journal

    Mikiko Hashisako*, Takeshi Iwasaki* (*Equally first), Takamasa Matsumoto, Yuichi Yamada, Takumi Miyamoto, Midori Taniguchi, Chiemi Oishi, Yoshinao Oda

    Pathol Res Pract   244   2023.4

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    DOI: 10.1016/j.prp.2023.154384.

  • Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. Invited Reviewed International journal

    Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori

    Cell Reports   42 ( 1 )   111929   2023.1

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    DOI: doi: 10.1016/j.celrep.2022.111929.

  • Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma is Associated with JAK-STAT and MEK-ERK Pathway Activation Reviewed International journal

    Iwasaki, Takeshi; Hayashi, Kazuhiko; Matsushita, Michiko; Nonaka, Daisuke; Kohashi, Kenichi; Kuwamoto, Satoshi; Umekita, Yoshihisa; Oda, Yoshinao

    Cancer Science   2022.1

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    DOI: https://doi.org/10.1111/cas.15187

  • Association of PD-L1 and IDO1 expression with JAK-STAT pathway activation in soft-tissue leiomyosarcoma Reviewed International journal

    Iwasaki, Takeshi; Kohashi, Kenichi; Toda, Yu; Ishihara, Shin; Yamada, Yuichi; Oda, Yoshinao

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-020-03390-9

  • Establishment and Characterization of a Novel Primitive Yolk Sac Tumour Cell Line, TC587 Reviewed International journal

    Iwasaki, Takeshi; Kohashi, Kenichi; Ohno, Masasuke; Taguchi, Tomoaki; Oda, Yoshinao

    ANTICANCER RESEARCH   40 ( 2 )   759 - 766   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14007

  • Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration Reviewed International journal

    Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka, Yasuyuki Ohkawa

    Nature Communications   9 ( 1 )   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-03845-1

  • Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis Reviewed International journal

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kuwamoto, Satoshi; Murakami, Ichiro; Hayashi, Kazuhiko

    Human pathology   48   1 - 8   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2015.09.030

  • Phosphohistone-H3 (PHH3) is prognostic relevant in Merkel cell carcinomas but Merkel cell polyomavirus is a more powerful prognostic factor than AJCC clinical stage, PHH3, Ki-67 or mitotic indices Reviewed International journal

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Kato, Masako; Nagata, Keiko; Murakami, Ichiro; Hayashi, Kazuhiko

    PATHOLOGY INTERNATIONAL   65 ( 8 )   404 - 409   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pin.12305

  • Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas Reviewed International journal

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Kuwamoto, Satoshi; Kato, Masako; Murakami, Ichiro; Nagata, Keiko; Nakajima, Hideki; Sano, Shigetoshi; Hayashi, Kazuhiko

    Human pathology   46 ( 2 )   210 - 216   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2014.07.025

  • Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs Reviewed International journal

    Matsushita, Michiko*; Iwasaki, Takeshi*; Kuwamoto, Satoshi; Kato, Masako; Nagata, Keiko; Murakami, Ichiro; Kitamura, Yukisato; Hayashi, Kazuhiko (*Equally first)

    VIRUS GENES   48 ( 2 )   233 - 242   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11262-013-1023-y

  • Usefulness of significant morphologic characteristics in distinguishing between Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative Merkel cell carcinomas Reviewed International journal

    Iwasaki, Takeshi; Matsushita, Michiko; Kuwamoto, Satoshi; Kato, Masako; Murakami, Ichiro; Higaki-Mori, Hiromi; Nakajima, Hideki; Sano, Shigetoshi; Hayashi, Kazuhiko

    Human pathology   44 ( 9 )   1912 - 1917   2013.9

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    DOI: 10.1016/j.humpath.2013.01.026

  • Gene amplification of chromatin remodeling factor SMARCC2 and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma. International journal

    27 ( 5 )   196 - 196   2024.5

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    Ovarian high-grade serous carcinoma (OHGSC) is the most common type of ovarian cancer worldwide. Genome sequencing has identified mutations in chromatin remodeling factors (CRFs) in gynecological cancer, such as clear cell carcinoma, endometrioid carcinoma and endometrial serous carcinoma. However, to the best of our knowledge, the association between CRFs and OHGSC remains unexplored. The present study aimed to investigate the clinicopathological and molecular characteristics of CRF dysfunction in OHGSC. CRF alterations were analyzed through numerous methods, including the analysis of public next-generation sequencing (NGS) data from 585 ovarian serous carcinoma cases from The Cancer Genome Atlas (TCGA), immunohistochemistry (IHC), and DNA copy number assays, which were performed on 203 surgically resected OHGSC samples. In the public NGS dataset, the most frequent genetic alteration was actin-like protein 6A (ACTL6A) amplification at 19.5%. Switch/sucrose non-fermentable related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 (SMARCC2) amplification (3.1%) was associated with significantly decreased overall survival (OS). In addition, chromodomain-helicase-DNA-binding protein 4 (CHD4) amplification (5.7%) exhibited unfavorable outcome trends, although not statistically significant. IHC revealed the protein expression loss of ARID1A (2.5%), SMARCA2 (2.5%) and SMARCA4 (3.9%). The protein expression levels of ACTL6A, SMARCC2 and CHD4 were evaluated using H-score. Patients with low protein expression levels of ACTL6A showed a significantly decreased OS. Copy number gain or gene amplification was demonstrated in ACTL6A (66.2%) and SMARCC2 (33.5%), while shallow deletion or deep deletion was demonstrated in CHD4 (70.7%). However, there was no statistically significant difference in protein levels of these CRFs, between the different copy number alterations (CNAs). Overall, OHGSC exhibited CNAs and protein loss, indicating possible gene alterations in CRFs. Moreover, there was a significant association between the protein expression levels of ACTL6A and poor prognosis. Based on these findings, it is suggested that CRFs could serve as prognostic markers for OHGSC.

    DOI: 10.3892/ol.2024.14329

  • Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma. International journal

    Kengo Kawaguchi, Kenichi Kohashi, Takeshi Iwasaki, Taro Mori, Hiroshi Furukawa, Chiaki Sato, Hiroki Sonoda, Sakura Shiraishi, Makoto Endo, Yasuharu Nakashima, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   2024.3

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    DOI: 10.1007/s00428-024-03796-7

  • DDIT3-amplified or low-polysomic pleomorphic sarcomas without MDM2 amplification: Clinicopathological review and immunohistochemical profile of nine cases. Reviewed International journal

    Taro Mori, Takeshi Iwasaki, Hiroki Sonoda, Kengo Kawaguchi, Takumi Tomonaga, Hiroshi Furukawa, Chiaki Sato, Sakura Shiraishi, Kenichi Taguchi, Sadafumi Tamiya, Reiko Yoneda, Yumi Oshiro, Tomoya Matsunobu, Chie Abe, Yusuke Kuboyama, Nozomi Ueki, Kenichi Kohashi, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda

    Human pathology   145   56 - 62   2024.3   ISSN:0046-8177 eISSN:1532-8392

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    Several high-grade pleomorphic sarcoma cases that cannot be classified into any existing established categories have been reported. These cases were provisionally classified into undifferentiated pleomorphic sarcoma (UPS). Some dedifferentiated liposarcoma (DDLS) cases may also have been classified into the UPS category due to the absence of MDM2 amplification or an atypical lipomatous tumor/well-differentiated liposarcoma component. We retrieved and reviewed 77 high-grade pleomorphic sarcoma cases, initially diagnosed as UPS in 66 cases and DDLS in 11 cases. Fluorescence in situ hybridization (FISH) analyses of DDIT3 and MDM2 were performed for available cases. Of the cases successfully subjected to DDIT3 FISH (n = 56), nine (7 UPS and 2 DDLS) showed DDIT3 amplification but no MDM2 amplification. Two UPS cases showed both telomeric (5') and centromeric (3') amplification of DDIT3 or low polysomy of chromosome 12, whereas 5 UPS and 2 DDLS cases showed 5'-predominant DDIT3 amplification. Histopathologically, all cases showed UPS-like proliferation of atypical pleomorphic tumor cells. Immunohistochemically, only one case showed focal nuclear positivity for DDIT3, supporting the previous finding that DDIT3 expression was not correlated with DDIT3 amplification. All three cases with focal MDM2 expression involved 5'-predominant amplification, two of which showed DDLS-like histological features. The majority of cases (7/9) showed decreased expression in p53 staining, suggesting that DDIT3 amplification regulates the expression of TP53 like MDM2. From a clinicopathological perspective, we hypothesize that DDIT3-amplified sarcoma, especially with 5'-predominant amplification, can be reclassified out of the UPS category.

    DOI: 10.1016/j.humpath.2024.02.007

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  • Rare presentation of a primary intraosseous glomus tumor in the humerus of a teenager. International journal

    Kengo Kawaguchi, Kenichi Kohashi, Nokitaka Setsu, Koji Sagiyama, Makoto Endo, Takeshi Iwasaki, Yasuharu Nakashima, Yoshinao Oda

    Skeletal radiology   2024.2

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    DOI: 10.1007/s00256-024-04604-8

  • Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma. International journal

    Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Takuma Izumi, Shohei Yoshiya, Takeo Toshima, Mizuki Ninomiya, Takeshi Iwasaki, Yoshinao Oda, Tomoharu Yoshizumi

    Cancer science   115 ( 1 )   170 - 183   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15981

  • Impact of <scp>ACSL4</scp> on the prognosis of hepatocellular carcinoma: Association with cancer‐associated fibroblasts and the tumour immune microenvironment

    Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Takahiro Tomiyama, Shohei Yoshiya, Takeo Toshima, Yu‐Chen Liu, Takeshi Iwasaki, Daisuke Okuzaki, Koji Taniguchi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

    2024.1

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    Abstract

    Background &amp; Aims

    Recently, the association between hepatocellular carcinoma (HCC) and ferroptosis has been the focus of much attention. The expression of long chain fatty acyl‐CoA ligase 4 (ACSL4), a marker of ferroptosis, in tumour tissue is related to better prognosis in various cancers. In HCC, ACSL4 expression indicates poor prognosis and is related to high malignancy. However, the mechanism remains to be fully understood.

    Methods

    We retrospectively enrolled 358 patients with HCC who had undergone hepatic resection. Immunohistochemistry (IHC) for ACSL4 was performed. Factors associated with ASCL4 expression were investigated by spatial transcriptome analysis, and the relationships were investigated by IHC. The association between ACSL4 and the tumour immune microenvironment was examined in a public dataset and investigated by IHC.

    Results

    Patients were divided into ACSL4‐positive (n = 72, 20.1&#37;) and ACSL4‐negative (n = 286, 79.9&#37;) groups. ACSL4 positivity was significantly correlated with higher α‐fetoprotein (p = .0180) and more histological liver fibrosis (p = .0014). In multivariate analysis, ACSL4 positivity was an independent prognostic factor (p < .0001). Spatial transcriptome analysis showed a positive correlation between ACSL4 and cancer‐associated fibroblasts; this relationship was confirmed by IHC. Evaluation of a public dataset showed the correlation between ACSL4 and exhausted tumour immune microenvironment; this relationship was also confirmed by IHC.

    Conclusion

    ACSL4 is a prognostic factor in HCC patients and its expression was associated with cancer‐associated fibroblasts and anti‐tumour immunity.

    DOI: 10.1111/liv.15839

  • Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease Reviewed International journal

    Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda, Kazuhiko Yamamoto, Yuta Kochi, Yoshihiro Baba

    Frontiers in Immunology   14   2023.9

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    DOI: 10.3389/fimmu.2023.1276014

  • MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma. Invited Reviewed International journal

    Takayuki Nakanishi, Yasuto Yoneshima, Koji Okamura, Toyoshi Yanagihara, Mikiko Hashisako, Takeshi Iwasaki, Naoki Haratake, Shun Mizusaki, Keiichi Ota, Eiji Iwama, Tomoyoshi Takenaka, Kentaro Tanaka, Tomoharu Yoshizumi, Yoshinao Oda, Isamu Okamoto

    Cancer science   2023.8

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    DOI: 10.1111/cas.15921

  • Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma. Reviewed International journal

    Kengo Kawaguchi, Kenichi Kohashi, Taro Mori, Hidetaka Yamamoto, Takeshi Iwasaki, Izumi Kinoshita, Yosuke Susuki, Hiroshi Furukawa, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda

    Journal of clinical pathology   2023.5

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    DOI: 10.1136/jcp-2023-208814

  • A newly proposed grading system of nuclear morphology and the molecular genetic background in myxoid liposarcoma Reviewed International journal

    Kawaguchi, K; Kohashi, K; Ishihara, S; Toda, Y; Iwasaki, T; Yamamoto, T; Endo, M; Matsumoto, Y; Oda, Y

    CANCER SCIENCE   114   266 - 266   2023.2   ISSN:1347-9032 eISSN:1349-7006

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  • Expression of SATB2, RUNX2, and SOX9 and possible osteoblastic and chondroblastic differentiation in chondroblastoma Invited Reviewed International journal

    Yu Toda, Hidetaka Yamamoto, Takeshi Iwasaki, Shin Ishihara, Yoshihiro Ito, Yosuke Susuki, Kengo Kawaguchi, Izumi Kinoshita, Daisuke Kiyozawa, Yuichi Yamada, Kenichi Kohashi, Atsushi Kimura, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda

    PATHOLOGY RESEARCH AND PRACTICE   241   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2022.154239

  • Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. Reviewed International journal

    Shin Ishihara, Takeshi Iwasaki, Kenichi Kohashi, Kengo Kawaguchi, Yu Toda, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda

    Journal of cancer research and clinical oncology   149 ( 6 )   2425 - 2436   2023.1

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    DOI: 10.1007/s00432-022-04078-y

  • Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene. Reviewed International journal

    Masahiko Tanigawa, Yutaka Koga, Yoshiki Naito, Hiroshi Yamaguchi, Takeshi Iwasaki, Kenichi Kohashi, Nobuyuki Ohike, Keiji Hanada, Michiyo Higashi, Masato Komatsu, Hiroshi Imai, Keisuke Yamakita, Tatsuya Nagakawa, Yoshinobu Okabe, Seiya Kato, Hirotsugu Noguchi, Toshiyuki Nakayama, Masanori Yasuda, Hironori Kusano, Jun Akiba, Yoshinao Oda, Hirohisa Yano

    Histopathology   81 ( 3 )   319 - 328   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/his.14703

  • Histological background of dedifferentiated solitary fibrous tumour. Reviewed International journal

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Journal of clinical pathology   75 ( 6 )   397 - 403   2022.6

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    DOI: 10.1136/jclinpath-2020-207311

  • Approach for reclassification of collecting duct carcinoma and comparative histopathological analysis with SMARCB1/INI1-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma. Reviewed International journal

    Daisuke Kiyozawa, Kenichi Kohashi, Dai Takamatsu, Takeshi Iwasaki, Daiki Shibata, Takumi Tomonaga, Yuki Tateishi, Masatoshi Eto, Mitsuru Kinjo, Kenichi Nishiyama, Kenichi Taguchi, Yumi Oshiro, Yusuke Kuboyama, Mitsuko Furuya, Yoshinao Oda

    Human pathology   124   36 - 44   2022.6   ISSN:0046-8177 eISSN:1532-8392

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    Collecting duct carcinoma (CDC) is a rare subset of high-grade renal cell carcinoma (RCC). To diagnose CDC, it is necessary to rule out other renal tumors including renal medullary carcinoma and fumarate hydratase (FH)-deficient RCC. However, there is overlap in the morphology of these three tumors, which all have poor outcomes. There is also still a need to sufficiently examine the therapeutic strategies for each of these tumors. In this study, we retrospectively reclassified invasive/infiltrating high-grade RCC and investigated its pathological features. We reviewed 18 cases previously diagnosed as "CDC," "FH-deficient RCC," and "unclassified RCC," which were reclassified as SMARCB1/INI1-deficient RCC, FH-deficient RCC, and CDC by SMARCB1/INI1, FH, and 2SC immunohistochemistry (IHC) and FH gene mutational status. As the result, 18 cases were reclassified into 2 cases of SMARCB1/INI1-deficient RCC, 7 cases of FH-deficient RCC, and 9 cases of CDC. The morphological features of each group overlapped, and no specific immunohistochemical expression except for SMARCB1/INI1, FH, and 2SC was detected. These results suggest that invasive/infiltrating high-grade RCC should be diagnosed by the combination of immunohistochemistry and molecular biological technique.

    DOI: 10.1016/j.humpath.2022.03.002

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  • Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation Reviewed International journal

    Ishihara, Shin; Yamamoto, Hidetaka; Iwasaki, Takeshi; Toda, Yu; Yamamoto, Takeo; Yoshimoto, Masato; Ito, Yoshihiro; Susuki, Yousuke; Kawaguchi, Kengo; Kinoshita, Izumi; Yamada, Yuichi; Kohashi, Kenichi; Fujiwara, Toshifumi; Setsu, Nokitaka; Endo, Makoto; Matsumoto, Yoshihiro; Kakuda, Yuko; Nakashima, Yasuharu; Oda, Yoshinao

    MODERN PATHOLOGY   2022.5

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    DOI: 10.1038/s41379-021-00972-x

  • Cyclin-dependent kinase 8 is an independent prognosticator in uterine leiomyosarcoma. Reviewed International journal

    Nobuko Yasutake, Takeshi Iwasaki, Hidetaka Yamamoto, Kenzo Sonoda, Keisuke Kodama, Kaoru Okugawa, Kazuo Asanoma, Hideaki Yahata, Kiyoko Kato, Yoshinao Oda

    Pathology, research and practice   235   153920 - 153920   2022.4

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    DOI: 10.1016/j.prp.2022.153920

  • Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases. Reviewed International journal

    Yuichi Yamada, Izumi Kinoshita, Yoshiko Miyazaki, Yuki Tateishi, Yusuke Kuboyama, Takeshi Iwasaki, Kenichi Kohashi, Hidetaka Yamamoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yosuke Susuki, Kengo Kawaguchi, Mikiko Hashisako, Yui Yamada-Nozaki, Daisuke Kiyozawa, Taro Mori, Takeo Yamamoto, Kenji Tsuchihashi, Kazumi Kuriwaki, Munenori Mukai, Masataka Kawai, Keiko Suzuki, Hirotake Nishimura, Kenji Bando, Junya Masumoto, Mana Fukushima, Junichi Motoshita, Hiroki Mori, Akira Shiose, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   480 ( 4 )   919 - 925   2022.4

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    DOI: 10.1007/s00428-022-03293-9

  • TROP2 Expression in Sebaceous and Sweat Gland Carcinoma. Reviewed International journal

    Takamichi Ito, Hiroki Hashimoto, Yuka Tanaka, Keiko Tanegashima, Maho Murata, Toshio Ichiki, Takeshi Iwasaki, Yoshinao Oda, Yumiko Kaku-Ito

    Journal of clinical medicine   11 ( 3 )   2022.1

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    DOI: 10.3390/jcm11030607

  • Risk factors for excessive postoperative sliding of femoral trochanteric fracture in elderly patients: A retrospective multicenter study Reviewed International journal

    Momii K, Fujiwara T, Mae T, Tokunaga M, Iwasaki T, Shiomoto K, Kubota K, Onizuka T, Miura T, Hamada T, Nakamura T, Itokawa T, Iguchi T, Yamashita A, Kikuchi N, Nakaie K, Matsumoto Y, Nakashima Y

    Injury   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.injury.2021.07.039.

  • The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma Reviewed International journal

    Shin Ishihara, Takeshi Iwasaki, Kenichi Kohashi, Yuichi Yamada, Yu Toda, Yoshihiro Ito, Yousuke Susuki, Kengo Kawaguchi, Dai Takamatsu, Shinichiro Kawatoko, Daisuke Kiyozawa, Taro Mori, Izumi Kinoshita, Hidetaka Yamamoto, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   147 ( 7 )   2003 - 2011   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-021-03616-4

  • Morphological, immunohistochemical, and genomic analyses of papillary renal neoplasm with reverse polarity Reviewed International journal

    Kiyozawa, Daisuke; Kohashi, Kenichi; Takamatsu, Dai; Yamamoto, Takeo; Eto, Masatoshi; Iwasaki, Takeshi; Motoshita, Junichi; Shimokama, Tatsuro; Kinjo, Mitsuru; Oshiro, Yumi; Yonemasu, Hirotoshi; Oda, Yoshinao

    Human pathology   112   48 - 58   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2021.03.009

  • Histological background of dedifferentiated solitary fibrous tumour. Reviewed International journal

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Journal of clinical pathology   2021.5

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    DOI: 10.1136/jclinpath-2020-207311

  • PD-L1 and IDO-1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I Reviewed International journal

    Ishihara, Shin; Yamada, Yuichi; Iwasaki, Takeshi; Yoshimoto, Masato; Toda, Yu; Kohashi, Kenichi; Yamamoto, Hidetaka; Matsumoto, Yoshihiro; Nakashima, Yasuharu; Oda, Yoshinao

    ONCOLOGY REPORTS   45 ( 1 )   379 - 389   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2020.7837

  • Frequent MN1 gene mutations in malignant peripheral nerve sheath tumor. Reviewed International journal

    Kinoshita I, Yamada Y, Kohashi K, Yamamoto H, Iwasaki T, Ishihara S, Toda YU, Ito Y, Susuki Y, Kawaguchi K, Ichiki T, Sato Y, Furue M, Nakashima Y, Oda Y.

    Anticancer Res.   40 ( 11 )   6221 - 6228   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.21873/anticanres.14642.

  • Clinicopathological features and immunohistochemical utility of NTRK, ALK and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas. Reviewed International journal

    Nozaki Y, Yamamoto H, Iwasaki T, Sato M, Jiromaru R, Hongo T, Yasumatsu R, Oda Y.

    Human pathology   106   82 - 92   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.humpath.2020.09.004.

  • PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients comparative study of primary and metastatic lesions Reviewed International journal

    Yu Toda, Kenichi Kohashi, Yuichi Yamada, Masato Yoshimoto, Shin Ishihara, Yoshihiro Ito, Takeshi Iwasaki, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda

    Journal of Cancer Research and Clinical Oncology   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-020-03242-6

  • Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death Reviewed International journal

    Yamada, Yuichi; Kohashi, Kenichi; Kinoshita, Izumi; Yamamoto, Hidetaka; Iwasaki, Takeshi; Yoshimoto, Masato; Ishihara, Shin; Toda, Yu; Itou, Yoshihiro; Koga, Yutaka; Hashisako, Mikiko; Nozaki, Yui; Kiyozawa, Daisuke; Kitahara, Daichi; Inoue, Takeshi; Mukai, Munenori; Honda, Yumi; Toyokawa, Gouji; Tsuchihashi, Kenji; Matsushita, Yoshifumi; Fushimi, Fumiyoshi; Taguchi, Kenichi; Tamiya, Sadafumi; Oshiro, Yumi; Furue, Masutaka; Nakashima, Yasuharu; Suzuki, Satoshi; Iwaki, Toru; Oda, Yoshinao

    VIRCHOWS ARCHIV   475 ( 4 )   467 - 477   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00428-019-02622-9

  • Decreased H3K27me3 Expression Is Associated With Merkel Cell Polyomavirus-negative Merkel Cell Carcinoma, Especially Combined With Cutaneous Squamous Cell Carcinoma Reviewed International journal

    Matsushita, Michiko; Iwasaki, Takeshi; Wardhani, Lusi Oka; Kuwamoto, Satoshi; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kitamura, Yukisato; Hayashi, Kazuhiko

    ANTICANCER RESEARCH   39 ( 10 )   5573 - 5579   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13751

  • Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with Merkel cell polyomavirus status and prognosis in Merkel cell carcinoma Reviewed International journal

    Wardhani, Lusi Oka; Matsushita, Michiko; Iwasaki, Takeshi; Kuwamoto, Satoshi; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kitamura, Yukisato; Hayashi, Kazuhiko

    Human pathology   84   52 - 61   2019.2

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    DOI: 10.1016/j.humpath.2018.09.003

  • Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma. Reviewed International journal

    Yasutake N, Ohishi Y, Taguchi K, Hiraki Y, Oya M, Oshiro Y, Mine M, Iwasaki T, Yamamoto H, Kohashi K, Sonoda K, Kato K, Oda Y.

    Histopathology   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/his.13422

  • Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone Reviewed International journal

    Yamamoto, Hidetaka; Iwasaki, Takeshi; Yamada, Yuichi; Matsumoto, Yoshihiro; Otsuka, Hiroshi; Yoshimoto, Masato; Kohashi, Kenichi; Taguchi, Kenichi; Yokoyama, Ryohei; Nakashima, Yasuharu; Oda, Yoshinao

    Human pathology   73   41 - 50   2018.3

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    DOI: 10.1016/j.humpath.2017.11.020

  • Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant Reviewed International journal

    Yamada, Yuichi; Kinoshita, Izumi; Kenichi, Kohashi; Yamamoto, Hidetaka; Iwasaki, Takeshi; Otsuka, Hiroshi; Yoshimoto, Masato; Ishihara, Shin; Toda, Yu; Kuma, Yuki; Setsu, Nokitaka; Koga, Yuki; Honda, Yumi; Inoue, Takeshi; Yanai, Hiroyuki; Yamashita, Kyoko; Ito, Ichiro; Takahashi, Mitsuru; Ohga, Shouichi; Furue, Masutaka; Nakashima, Yasuharu; Oda, Yoshinao

    HISTOPATHOLOGY   72 ( 3 )   460 - 471   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/his.13377

  • Sensitive detection of fluorescence in western blotting by merging images Reviewed International journal

    Kondo, Yukari; Higa, Shinichiro; Iwasaki, Takeshi; Matsumoto, Tomoya; Maehara, Kazumitsu; Harada, Akihito; Baba, Yoshihiro; Fujita, Masatoshi; Ohkawa, Yasuyuki

    PLOS ONE   13 ( 1 )   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0191532

  • Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma Reviewed International journal

    Kuromi, Teruyuki; Matsushita, Michiko; Iwasaki, Takeshi; Nonaka, Daisuke; Kuwamoto, Satoshi; Nagata, Keiko; Kato, Masako; Akizuki, Gen; Kitamura, Yukisato; Hayashi, Kazuhiko

    Human pathology   69   8 - 14   2017.11

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    DOI: 10.1016/j.humpath.2017.05.011

  • Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas Reviewed International journal

    Matsushita, Michiko; Iwasaki, Takeshi; Nonaka, Daisuke; Kuwamoto, Satoshi; Nagata, Keiko; Kato, Masako; Kitamura, Yukisato; Hayashi, Kazuhiko

    YONAGO ACTA MEDICA   60 ( 3 )   145 - 153   2017.9

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  • Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. Reviewed International journal

    Wang H, Kohashi K, Yoshizumi T, Okumura Y, Tanaka Y, Shimokawa M, Iwasaki T, Aishima S, Maehara Y, Oda Y

    Human Pathology   64   69 - 75   2017.6

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    DOI: 10.1016/j.humpath.2017.03.007

  • Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8 Reviewed International journal

    Taguchi, Hiroyuki; Xie, Yan; Horikoshi, Naoki; Maehara, Kazumitsu; Harada, Akihito; Nogami, Jumpei; Sato, Koichi; Arimura, Yasuhiro; Osakabe, Akihisa; Kujirai, Tomoya; Iwasaki, Takeshi; Semba, Yuichiro; Tachibana, Taro; Kimura, Hiroshi; Ohkawa, Yasuyuki; Kurumizaka, Hitoshi

    BIOCHEMISTRY   56 ( 16 )   2184 - 2196   2017.4

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    DOI: 10.1021/acs.biochem.6b01098

  • Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors Reviewed International journal

    Bekki, Hirofumi; Yamamoto, Hidetaka; Takizawa, Katsumi; Iwasaki, Takeshi; Otsuka, Hiroshi; Yamada, Yuichi; Kohashi, Kenichi; Harimaya, Katsumi; Iwamoto, Yukihide; Oda, Yoshinao

    PATHOLOGY RESEARCH AND PRACTICE   213 ( 6 )   674 - 679   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.prp.2016.12.001

  • Identification of Immunoglobulin Gene Sequences from a Small Read Number of mRNA-Seq Using Hybridomas Reviewed International journal

    Kuniyoshi, Yuki; Maehara, Kazumitsu; Iwasaki, Takeshi; Hayashi, Masayasu; Semba, Yuichiro; Fujita, Masatoshi; Sato, Yuko; Kimura, Hiroshi; Harada, Akihito; Ohkawa, Yasuyuki

    PLoS One   11 ( 10 )   2016.10

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    DOI: 10.1371/journal.pone.0165473

  • Prognostic Significance of Forkhead Box M1 (FOXM1) Expression and Antitumor Effect of FOXM1 Inhibition in Angiosarcoma Reviewed International journal

    Ito, Takamichi; Kohashi, Kenichi; Yamada, Yuichi; Iwasaki, Takeshi; Maekawa, Akira; Kuda, Masaaki; Hoshina, Daichi; Abe, Riichiro; Furue, Masutaka; Oda, Yoshinao

    JOURNAL OF CANCER   7 ( 7 )   823 - 830   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7150/jca.14461

  • Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface Reviewed International journal

    Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Marika Ochi, Kyosuke Kanai, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Takeshi Iwasaki, Eiji Nanba, Hiroshi Kimura, Kazuhiko Hayashi

    Autoimmunity   48 ( 5 )   328 - 335   2015.8

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    DOI: 10.3109/08916934.2015.1022163

  • Acute-phase ITIH4 levels distinguish multi-system from single-system Langerhans cell histiocytosis via plasma peptidomics Reviewed International journal

    Murakami, Ichiro; Oh, Yukiko; Morimoto, Akira; Sano, Hitoshi; Kanzaki, Susumu; Matsushita, Michiko; Iwasaki, Takeshi; Kuwamoto, Satoshi; Kato, Masako; Nagata, Keiko; Hayashi, Kazuhiko; Imashuku, Shinsaku; Gogusev, Jean; Jaubert, Francis; Oka, Takashi; Yoshino, Tadashi

    CLINICAL PROTEOMICS   12   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12014-015-9089-2

  • Immunoglobulin Expressions Are Only Associated With MCPyV-positive Merkel Cell Carcinomas But Not With MCPyV-negative Ones Comparison of Prognosis Reviewed International journal

    Murakami, Ichiro; Takata, Katsuyoshi; Matsushita, Michiko; Nonaka, Daisuke; Iwasaki, Takeshi; Kuwamoto, Satoshi; Kato, Masako; Mohri, Takashi; Nagata, Keiko; Kitamura, Yukisato; Yoshino, Tadashi; Hayashi, Kazuhiko

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   38 ( 12 )   1627 - 1635   2014.12

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  • High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues Reviewed International journal

    Murakami, Ichiro; Matsushita, Michiko; Iwasaki, Takeshi; Kuwamoto, Satoshi; Kato, Masako; Horie, Yasushi; Hayashi, Kazuhiko; Gogusev, Jean; Jaubert, Francis; Nakamoto, Shu; Yamakawa, Mitsunori; Nakamine, Hirokazu; Takata, Katsuyoshi; Oka, Takashi; Yoshino, Tadashi

    INFECTIOUS AGENTS AND CANCER   9   2014.5

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    DOI: 10.1186/1750-9378-9-15

  • Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves' disease patients and in healthy individuals Reviewed International journal

    Nagata, Keiko; Higaki, Katsumi; Nakayama, Yuji; Miyauchi, Hiromi; Kiritani, Yui; Kanai, Kyosuke; Matsushita, Michiko; Iwasaki, Takeshi; Sugihara, Hirotsugu; Kuwamoto, Satoshi; Kato, Masako; Murakami, Ichiro; Nanba, Eiji; Kimura, Hiroshi; Hayashi, Kazuhiko

    AUTOIMMUNITY   47 ( 3 )   193 - 200   2014.5

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    DOI: 10.3109/08916934.2013.879863

  • A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV) Reviewed International journal

    Matsushita, Michiko; Nonaka, Daisuke; Iwasaki, Takeshi; Kuwamoto, Satoshi; Murakami, Ichiro; Kato, Masako; Nagata, Keiko; Kitamura, Yukisato; Hayashi, Kazuhiko

    DIAGNOSTIC PATHOLOGY   9   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1746-1596-9-65

  • Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis Reviewed International journal

    Murakami, Ichiro; Matsushita, Michiko; Iwasaki, Takeshi; Kuwamoto, Satoshi; Kato, Masako; Horie, Yasushi; Hayashi, Kazuhiko; Imamura, Toshihiko; Morimoto, Akira; Imashuku, Shinsaku; Gogusev, Jean; Jaubert, Francis; Takata, Katsuyoshi; Oka, Takashi; Yoshino, Tadashi

    Human pathology   45 ( 1 )   119 - 126   2014.1

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    DOI: 10.1016/j.humpath.2013.05.028

  • Detection of Merkel Cell Polyomavirus in the Human Tissues from 41 Japanese Autopsy Cases Using Polymerase Chain Reaction Reviewed International journal

    Matsushita, Michiko; Kuwamoto, Satoshi; Iwasaki, Takeshi; Higaki-Mori, Hiromi; Yashima, Shoji; Kato, Masako; Murakami, Ichiro; Horie, Yasushi; Kitamura, Yukisato; Hayashi, Kazuhiko

    INTERVIROLOGY   56 ( 1 )   1 - 5   2013.9

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    DOI: 10.1159/000338620

  • Association of Merkel cell polyomavirus infection with clinicopathological differences in Merkel cell carcinoma Reviewed International journal

    Higaki-Mori, Hiromi; Kuwamoto, Satoshi; Iwasaki, Takeshi; Kato, Masako; Murakami, Ichiro; Nagata, Keiko; Sano, Hitoshi; Horie, Yasushi; Yoshida, Yuichi; Yamamoto, Osamu; Adachi, Kaori; Nanba, Eiji; Hayashi, Kazuhiko

    Human pathology   43 ( 12 )   2282 - 2291   2012.12

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    DOI: 10.1016/j.humpath.2012.04.002

  • Association of merkel cell polyomavirus infection with morphologic differences in merkel cell carcinoma Reviewed International journal

    Kuwamoto, Satoshi; Higaki, Hiromi; Kanai, Kyosuke; Iwasaki, Takeshi; Sano, Hitoshi; Nagata, Keiko; Kato, Kaoru; Kato, Masako; Murakami, Ichiro; Horie, Yasushi; Yamamoto, Osamu; Hayashi, Kazuhiko

    Human pathology   42 ( 5 )   632 - 640   2011.5

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    DOI: 10.1016/j.humpath.2010.09.011

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Presentations

  • Merkel Cell Polyomavirus–Negative Merkel Cell Carcinoma is Associated with JAK-STAT and MEK-ERK Pathway Activation International conference

    2021.3 

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    Event date: 2021.3

    Language:English  

    Venue:Online   Country:Japan  

MISC

  • Recurrent Massive Hemothorax of Unknown Etiology in an 85-Year-Old Man. Reviewed

    Okamatsu Y, Tsubouchi K, Iwasaki T, Nakamura T, Nakashima T, Nakatsuru K, Takahata Y, Harada T.

    Chest   2022.2

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    DOI: 10.1016/j.chest.2021.09.012.

  • First case of pyrin-associated autoinflammation with neutrophilic dermatosis complicated by amyloidosis. Reviewed

    Kiyota M, Oya M, Ayano M, Niiro H, Iwasaki T, Fujiwara M, Oda Y, Fujimoto K, Ida H

    Rheumatology   2020.10

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    DOI: 10.1093/rheumatology/keaa005.

  • Current Update on the Molecular Biology of Cutaneous Sarcoma: Dermatofibrosarcoma Protuberans. Reviewed

    @Iwasaki T, @Yamamoto H, @Oda Y.

    Current treatment options in oncology   2019.3

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    DOI: 10.1007/s11864-019-0628-3

  • Comment on 'Cytokeratin 20-negative Merkel cell carcinoma is infrequently associated with the Merkel cell polyomavirus'

    Takeshi Iwasaki, Michiko Matsushita, Daisuke Nonaka, Ichiro Murakami, Kazuhiko Hayashi

    Modern Pathology   2016.1

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    DOI: 10.1038/modpathol.2015.69

  • Merkel cell polyomavirus infection in both components of a combined Merkel cell carcinoma and basal cell carcinoma with ductal differentiation; each component had a similar but different novel Merkel cell polyomavirus large T antigen truncating mutation. Reviewed

    Iwasaki T, Kodama H, Matsushita M, Kuroda N, Yamasaki Y, Murakami I, Yamamoto O, Hayashi K.

    Human pathology.   2013.3

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    DOI: 10.1016/j.humpath.2012.08.022.

  • Tumor Embolism as a Cause of Renal Artery Occlusion and Acute Kidney Injury Diagnosed and Treated with Endovascular Intervention in a Patient with Mediastinal Undifferentiated Sarcoma Reviewed

    Kazuya Tsubouchi, Ritsu Ibusuki, Kenji Makisumi, Hirofumi Okamoto, @RTakeshi Iwasaki, Yuki Okamatsu, Katsuhiro Inoue, Taishi Harada

    Intern Med.   2021.6

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    DOI: 10.2169/internalmedicine.6249-20

  • Deep Learningを用いた乳癌HE染色画像解析とタンパク発現予測に関する研究

    原田 由梨菜, 中津川 宗秀, 久保 真, 甲斐 昌也, 山田 舞, 森 瞳美, 川地 眸, 金城 和寿, 林 早織, 島崎 亜希子, 森崎 隆史, 岩崎 健, 山元 英崇, 小田 義直, 中村 雅史

    日本外科学会定期学術集会抄録集   2021.4

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  • Yolk sac tumor新規細胞株TC587の樹立と網羅的遺伝子変異解析

    岩崎 健, 孝橋 賢一, 小田 義直

    日本病理学会会誌   2020.3

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  • 軟部平滑筋肉腫におけるPD-L1、IDO1発現とJak-Stat経路の活性化に関する検討

    岩崎 健, 山田 裕一, 石原 新, 戸田 雄, 孝橋 賢一, 小田 義直

    日本病理学会会誌   2020.3

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  • Remarkable response to nivolumab in sarcomatoid malignant pleural mesothelioma with high PD-L1.

    Kazuya Tsubouchi, Shigesato Inoue, Ritsu Ibusuki, Takeshi Iwasaki, Taishi Harada

    Respirology case reports   2020.2

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    Language:English   Publishing type:Internal/External technical report, pre-print, etc.  

    DOI: 10.1002/rcr2.536

  • 骨巨細胞腫におけるHistone H3.3 G34W、G34R、G34V変異特異的抗体の有用性

    山元 英崇, 岩崎 健, 山田 裕一, 孝橋 賢一, 田口 健一, 小田 義直

    日本病理学会会誌   2018.4

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  • 甲状腺乳頭癌におけるROS1発現とROS1遺伝子再構成の頻度及び臨床病理学的解析

    畑中 優衣, 山元 英崇, 岩崎 健, 佐藤 方宣, 次郎丸 梨那, 小田 義直

    日本病理学会会誌   2018.4

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  • 顕微鏡撮像を用いた高感度蛍光ウェスタン法

    比嘉 辰一郎, 近藤 友佳里, 岩崎 健, 原田 哲仁, 大川 恭行

    生命科学系学会合同年次大会   2017.12

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  • 新規ヒストンH3バリアントH3mm13は正常な骨格筋再生に必要である

    岩崎 健, 田口 裕之, 吉岡 潔志, 西村 洋平, 原田 哲仁, 前原 一満, 謝 炎, 林 克彦, 小野 悠介, 胡桃坂 仁志, 大川 恭行

    生命科学系学会合同年次大会   2017.12

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  • 血管肉腫におけるFOXM1発現と治療ターゲットとしての可能性

    伊東 孝通, 孝橋 賢一, 山田 裕一, 岩崎 健, 前川 啓, 久田 正昭, 古江 増隆, 小田 義直

    日本病理学会会誌   2016.4

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  • 骨格筋芽細胞C2C12の細胞分裂時の分化能継承メカニズムの探索

    工藤 健介, 國吉 勇輝, 岩崎 健, 仙波 雄一郎, 林 正康, 小田原 淳, 前原 一満, 原田 哲仁, 沖 英次, 前原 喜彦, 大川 恭行

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   2015.12

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    Language:Japanese  

  • 萎縮した筋組織における網羅的遺伝子発現動態解析

    岩崎 健, 原田 哲仁, 横田 和也, 岡田 誠司, 大川 恭行

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   2015.12

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    Language:Japanese  

  • Multiple Skin Cancers in a Renal Transplant Recipient: A Patient Report with Analyses of Human Papillomavirus and Human Polyomavirus Infection. Reviewed

    Kanda T, Matsushita M, Iwasaki T, Ishiguro N, Koide T, Hayashi K, Kitamura Y.

    Yonago acta medica   2015.10

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    Language:English   Publishing type:Internal/External technical report, pre-print, etc.  

  • Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis. Reviewed

    Murakami I, Matsushita M, @Iwasaki T, Kuwamoto S, Kato M, Nagata K, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.

    Cell communication and signaling   2015.2

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1186/s12964-015-0092-z

  • A pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features: a case report Reviewed

    Iwasaki T, Kato M, Horie Y, Kato S, Akatsuka K, Watanabe T, Kuwamoto S, Murakami I, Hayashi K.

    Neuropathology   2011.3

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    Language:English   Publishing type:Internal/External technical report, pre-print, etc.  

    DOI: 10.1111/j.1440-1789.2011.01209.x.

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Professional Memberships

  • 日本分子生物学会

  • 日本癌学会

  • 日本臨床細胞学会

  • 日本病理学会

  • International Academy of Pathology

  • United States and Canadian Academy of Pathology

  • International Academy of Pathology

  • United States and Canadian Academy of Pathology

  • 日本分子生物学会

  • 日本病理学会

  • 日本癌学会

  • 日本臨床細胞学会

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Committee Memberships

  • 臨床細胞学会   評議員  

    2025.4 - 2027.3   

  • 日本癌学会   評議員  

    2025.1   

  • 日本病理学会   分子病理専門医資格審査委員会 委員   Domestic

    2024.4 - Present   

  • Councilor   Domestic

    2023.4 - Present   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

Research Projects

  • 希少難治性消化器疾患の長期的QOL向上と小児期からのシームレスな医療体制構築.

    2024 - 2025

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • JA共済交通事故医療研究助成

    2024

    JA共済交通事故医療研究助成

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    Authorship:Principal investigator  Grant type:Contract research

  • 空間的マルチオミクス解析による軟部肉腫の腫瘍微小環境の解明と代謝標的治療法の探索

    Grant number:23H02694  2023 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 軟部肉腫の腫瘍微小環境内のメタボロインタラクトームを標的とした個別化医療の臨床実装

    2023 - 2024

    小林がん学術振興会 研究助成金 がんの予防・診断・治療に関する基礎的研究

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    Authorship:Principal investigator  Grant type:Contract research

  • シングルセル時空間マルチオミクス解析によるメルケル細胞癌の病態解明

    Grant number:22K15406  2022 - 2025

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 軟部肉腫のエピゲノムにおける空間的・時間的不均一性に基づく治療法開発の基盤研究

    2022 - 2025

    臨床医学振興財団助成金

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    Authorship:Principal investigator  Grant type:Contract research

  • メルケル細胞癌の腫瘍微小環境内のメタボロインタラクト―ムを標的とした新規治療戦略の確立

    2022 - 2024

    新日本先進医療研究財団助成金

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    Authorship:Principal investigator  Grant type:Contract research

  • エピトランスクリプトミクス破綻により引き起こされた軟部肉腫の解析

    Grant number:21K20805  2021 - 2022

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 希少癌における肉腫のマルチオミクス解析による発癌機序と治療抵抗性獲得機構の解明

    Grant number:19H03444  2019 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • エピジェネティック破綻により引き起こされたメルケル細胞癌の解析.

    2019 - 2020

    福岡県すこやか健康事業団 がん研究助成金

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    Authorship:Principal investigator  Grant type:Contract research

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Class subject

  • 病理学各論

    2024.10 - 2025.3   Second semester

  • 病理学総論

    2024.4 - 2024.9   First semester

  • 病因と病態Ⅱ

    2024.4 - 2024.9   First semester

  • 臨床腫瘍学の基本

    2024.4 - 2024.9   First semester

  • 生命医科学研究入門

    2023.10 - 2024.3   Second semester

  • 病態情報解析検査学

    2023.10 - 2024.3   Second semester

  • 病理学総論

    2023.4 - 2023.9   First semester

  • 臨床腫瘍学の基本

    2023.4 - 2023.9   First semester

  • 病因と病態Ⅱ

    2023.4 - 2023.9   First semester

  • 病理学各論

    2022.10 - 2023.3   Second semester

  • 病理学総論

    2022.4 - 2022.9   First semester

  • 臨床腫瘍学の基本

    2022.4 - 2022.9   First semester

  • 病因と病態Ⅱ

    2022.4 - 2022.9   First semester

  • 病因と病態Ⅱ

    2021.4 - 2021.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • 地域関連病院にて病理診断を行っている。

Specialized clinical area

  • Biological Sciences / Medicine, Dentistry and Pharmacy / Basic Medicine / Human Pathology

  • Biological Sciences / Medicine, Dentistry and Pharmacy / Basic Medicine / Experimental Pathology

Clinician qualification

  • 認定病理専門医

    The Japanese Society of Pathology

  • 細胞診専門医・教育研修指導医

    The Japanese Society of Clinical Cytology

  • 分子病理専門医

    The Japanese Society of Pathology

  • 認定産業医

    日本医師会

  • 死体解剖資格

    厚生労働省

Year of medical license acquisition

  • 2013