Updated on 2024/10/03

Information

 

写真a

 
HASHISAKO MIKIKO
 
Organization
Kyushu University Hospital Division of Diagnostic Pathology Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Concurrent)
Title
Assistant Professor
Profile
【研究】びまん性肺疾患、肺腫瘍の病理組織学的及び分子生物学的解析 【教育】医学部生および大学院生の講義・実習 【社会連携】病理医不在地域に対する診断支援 診断困難例に対するコンサルテーション
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Research Interests・Research Keywords

  • Research theme:Pulmonary Pathology

    Keyword:Pathology, Respiratory medicine

    Research period: 2013.4

Papers

  • Interobserver agreement of usual interstitial pneumonia diagnosis correlated with patient outcome Reviewed International journal

    Mikiko Hashisako, Tomonori Tanaka, Yasuhiro Terasaki, Toshimasa Uekusa, Rosane D. Achcar, Bassam I. Aswad, Hanaa S. Bamefleh, Vera L. Capelozzi, John C. English, Alexandre T. Fabro, Kensuke Kataoka, Tomayoshi Hayashi, Yasuhiro Kondoh, Hiroyuki Taniguchi, Junya Fukuoka

    Archives of Pathology and Laboratory Medicine   140 ( 12 )   1375 - 1382   2016.12

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    DOI: 10.5858/arpa.2016-0012-OA

  • Idiopathic dendriform pulmonary ossification as the phenotype of interstitial lung abnormalities: CT-pathologic correlation and prevalence

    Ueno, M; Egashira, R; Hashisako, M; Fujimoto, K; Fukuda, T; Hayashida, Y; Sumikawa, H; Tominaga, J; Tanaka, T; Terasaki, Y; Fukuoka, J; Nishioka, Y; Aoki, T; Gabata, T; Hatabu, H; Johkoh, T

    JAPANESE JOURNAL OF RADIOLOGY   42 ( 9 )   993 - 1002   2024.9   ISSN:1867-1071 eISSN:1867-108X

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    Background and purpose: Idiopathic dendriform pulmonary ossification (DPO) is mostly asymptomatic, and detected incidentally in lung CT. There have been no reports on the precise CT–pathologic correlation and the prevalence of idiopathic DPO. This study aimed to clarify the histological background and prevalence of idiopathic DPO. Materials and methods: Sixteen patients with histologically confirmed idiopathic DPO (12 men and 4 women; mean age, 38.8 years; range 22–56 years) were identified in a nationwide epidemiological survey. Local HRCT findings of pre-biopsy examinations, such as branching, round, linear structures with or without high attenuation were compared side by side with histological findings. The attenuation of branching, round, and linear structures was classified into three-point levels on bone window images (width, 2500 HU; level, 500 HU). Furthermore, we collected continuous pulmonary CT images of 8111 cases for checking up metastasis from extrathoracic malignancy at a single institution, and evaluated the prevalence of interstitial lung abnormalities (ILAs) and DPO. Results: In all 16 cases, branching (n = 15, 93%), round (n = 5, 31%), or linear (n = 5, 31%) structures were identified, histologically corresponding to dendriform ossification and cicatricial organizing pneumonia (OP)/fibrosis. Histologically, ossification was confirmed in all the 16 patients. However, in two cases, a highly attenuated structure could not be detected on the pre-biopsy CT of the same area. Regarding the prevalence of idiopathic DPO, 283 (3.5%) of 8111 patients had ILAs, of which a total of 26 (0.3% of all cases, 9.2% of ILAs cases) had DPO. Conclusion: Idiopathic DPO showed linear or branching structures with or without high attenuation on CT, corresponded to ossification, cicatricial OP/fibrosis. DPO was seen in 9.2% of ILAs cases. Idiopathic DPO is one of pathologic phenotypes of ILAs.

    DOI: 10.1007/s11604-024-01590-8

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  • Squamous metaplasia is an indicator of acute exacerbation in patients with usual interstitial pneumonia / idiopathic pulmonary fibrosis(タイトル和訳中)

    Tachibana Yuri, Hara Masatake, Hashisako Mikiko, Yamano Yasuhiko, Kataoka Kensuke, Kondoh Yasuhiro, Johkoh Takeshi, Morimoto Shimpei, Bychkov Andrey, Fukuoka Junya

    Respiratory Investigation   62 ( 4 )   631 - 637   2024.7   ISSN:2212-5345

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  • Squamous metaplasia is an indicator of acute exacerbation in patients with usual interstitial pneumonia / idiopathic pulmonary fibrosis

    Tachibana Y., Hara M., Hashisako M., Yamano Y., Kataoka K., Kondoh Y., Johkoh T., Morimoto S., Bychkov A., Fukuoka J.

    Respiratory Investigation   62 ( 4 )   631 - 637   2024.7   ISSN:22125345

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    Background: Acute exacerbation (AE) is a potentially lethal event in patients with usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF). However, to date, no pathological predictors of AE have been identified. This retrospective study aimed to elucidate the pathological features that could predict AE in patients with UIP. Methods: We reviewed the pathological findings of 91 patients with UIP/IPF and correlated these findings with AE events. Thirteen histological variables related to acute lung injury were evaluated by three independent observers and classified as positive or negative. The patients’ clinical data during follow-up were collected and reviewed for AE. A recursive partition using the Gini index for the prediction of AE was performed, with each pathological finding as a candidate for branching. Results: Twenty patients (22%) developed AE during the median follow-up duration of 40 months. Thirty-eight patients died (15 due to AE and 23 for other reasons). The median time interval from surgical lung biopsy to AE onset was 497 (interquartile range: 901–1657) days. Histologically, squamous metaplasia was positively associated with AE (odds ratio: 4.7, P = 0.015) and worse event-free survival in patients with UIP (P = 0.04). Leaf scoring based on the Gini index for recursive partition, including five positive findings (squamous metaplasia, neutrophilic infiltration, septal widening, Kuhn's hyaline, and fibrin), showed a sensitivity of 90% with a specificity of 74.7% (area under curve: 0.89). Conclusions: We found that squamous metaplasia is an important histopathological finding that predicts AE events and tends to unfavorable outcome in patients with UIP/IPF.

    DOI: 10.1016/j.resinv.2024.04.021

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  • Low-grade central osteosarcoma with extraosseous dedifferentiation: a rare case

    Kawaguchi, K; Kohashi, K; Sagiyama, K; Hashisako, M; Nabeshima, A; Setsu, N; Endo, M; Iwasaki, T; Nakashima, Y; Oda, Y

    SKELETAL RADIOLOGY   2024.3   ISSN:0364-2348 eISSN:1432-2161

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    Low-grade central osteosarcoma (LGCOS), which arises from the intramedullary cavity of the metaphysis of long bones, occasionally exhibits extraosseous spread. Approximately 10–30% of patients with LGCOS exhibit dedifferentiation, but it is rare to experience a primary tumor with a dedifferentiated component. A 38-year-old female patient presented with right knee pain for two months. Imaging studies revealed a bone mass with extraosseous involvement. Wide resection was performed, and pathologic examination led to the diagnosis of LGCOS with a dedifferentiated extraosseous lesion. A single defect in the bone cortex constituted the boundary between the low- and high-grade components. The extraosseous high-grade component included more tumor cells with p53 overexpression and more murine double minute 2 (MDM2) copies compared with the low-grade component. These genetic mutations and copy number alterations can be associated with malignant transformation of LGCOS.

    DOI: 10.1007/s00256-024-04647-x

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  • Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma: A Case Report

    Nakamura Satoshi, Takano Tomotsugu, Nakatsuru Kousei, Tsubouchi Kazuya, Yamauchi Takuji, Hashisako Mikiko, Iwasaki Takeshi, Okamoto Isamu

    Internal Medicine   advpub ( 0 )   2024   ISSN:09182918 eISSN:13497235

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    <p>Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF. </p>

    DOI: 10.2169/internalmedicine.3601-24

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  • Stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities on CT

    Fukuda, T; Egashira, R; Ueno, M; Hashisako, M; Sumikawa, H; Tominaga, J; Yamada, D; Fukuoka, J; Misumi, S; Ojiri, H; Hatabu, H; Johkoh, T

    INSIGHTS INTO IMAGING   14 ( 1 )   177   2023.10   ISSN:1869-4101

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    High-attenuation pulmonary abnormalities are commonly seen on CT. These findings are increasingly encountered with the growing number of CT examinations and the wide availability of thin-slice images. The abnormalities include benign lesions, such as infectious granulomatous diseases and metabolic diseases, and malignant tumors, such as lung cancers and metastatic tumors. Due to the wide spectrum of diseases, the proper diagnosis of high-attenuation abnormalities can be challenging. The assessment of these abnormal findings requires scrutiny, and the treatment is imperative. Our proposed stepwise diagnostic algorithm consists of five steps. Step 1: Establish the presence or absence of metallic artifacts. Step 2: Identify associated nodular or mass-like soft tissue components. Step 3: Establish the presence of solitary or multiple lesions if identified in Step 2. Step 4: Ascertain the predominant distribution in the upper or lower lungs if not identified in Step 2. Step 5: Identify the morphological pattern, such as linear, consolidation, nodular, or micronodular if not identified in Step 4. These five steps to diagnosing high-attenuation abnormalities subdivide the lesions into nine categories. This stepwise radiologic diagnostic approach could help to narrow the differential diagnosis for various pulmonary high-attenuation abnormalities and to achieve a precise diagnosis. Critical relevance statement Our proposed stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities may help to recognize a variety of those high-attenuation findings, to determine whether the associated diseases require further investigation, and to guide appropriate patient management. Key points • To provide a stepwise diagnostic approach to high-attenuation pulmonary abnormalities. • To familiarize radiologists with the varying cause of high-attenuation pulmonary abnormalities. • To recognize which high-attenuation abnormalities require scrutiny and prompt treatment. Graphical Abstract: [Figure not available: see fulltext.]

    DOI: 10.1186/s13244-023-01501-x

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  • 肺腺癌においてマイクロRNA-326はCD155発現を負に調節する(MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma)

    Nakanishi Takayuki, Yoneshima Yasuto, Okamura Koji, Yanagihara Toyoshi, Hashisako Mikiko, Iwasaki Takeshi, Haratake Naoki, Mizusaki Shun, Ota Keiichi, Iwama Eiji, Takenaka Tomoyoshi, Tanaka Kentaro, Yoshizumi Tomoharu, Oda Yoshinao, Okamoto Isamu

    Cancer Science   114 ( 10 )   4101 - 4113   2023.10   ISSN:1347-9032

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    肺癌におけるCD155発現を転写後レベルで調節している可能性があるマイクロRNA(miR)の同定を試みた。標的予測プログラムを用いた網羅的miRスクリーニングを行い、さらに二重ルシフェラーゼレポーターアッセイを施行した。その結果、CD155 mRNAの3'-UTRに結合するmiRとして4種(miR-346、miR-328-3p、miR-326、miR-330-5p)が同定された。これらのmiRを複数の肺癌細胞株で強制発現させるとCD155の発現が抑制された。肺腺癌患者57名の組織検体でCD155を標的とする免疫組織化学解析を行った。その結果、CD155の腫瘍割合スコアの中央値は68%となった。これらの組織検体のうちCD155発現レベルが低い検体では高い検体よりもmiR-326が豊富に存在していた(p<0.005)。本研究結果から、肺腺癌ではmiR-326はCD155発現を負方向へ調節していることが示唆された。CD155発現の亢進はPD-1/PD-L1阻害剤耐性の機序になっていることから、miR-326はその耐性の出現に際して何らかの役割を果たしていると考えられた。

  • MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma. International journal

    Takayuki Nakanishi, Yasuto Yoneshima, Koji Okamura, Toyoshi Yanagihara, Mikiko Hashisako, Takeshi Iwasaki, Naoki Haratake, Shun Mizusaki, Keiichi Ota, Eiji Iwama, Tomoyoshi Takenaka, Kentaro Tanaka, Tomoharu Yoshizumi, Yoshinao Oda, Isamu Okamoto

    Cancer science   114 ( 10 )   4101 - 4113   2023.8   ISSN:1347-9032 eISSN:1349-7006

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    Treatment with immune checkpoint inhibitors induces a durable response in some patients with non-small-cell lung cancer, but eventually gives rise to drug resistance. Upregulation of CD155 expression is implicated as one mechanism of resistance to programmed death receptor-1 (PD-1)/PD-1 ligand (PD-L1) inhibitors, and it is therefore important to characterize the mechanisms underlying regulation of CD155 expression in tumor cells. The aim of this study was to identify microRNAs (miRNAs) that might regulate CD155 expression at the posttranscriptional level in lung cancer. Comprehensive miRNA screening with target prediction programs and a dual-luciferase reporter assay identified miR-346, miR-328-3p, miR-326, and miR-330-5p as miRNAs that bind to the 3'-UTR of CD155 mRNA. Forced expression of these miRNAs suppressed CD155 expression in lung cancer cell lines. Immunohistochemical staining of CD155 in tissue specimens from 57 patients with lung adenocarcinoma revealed the median tumor proportion score for CD155 to be 68%. The abundance of miR-326 in these specimens with a low level of CD155 expression was significantly greater than in specimens with a high level (p < 0.005). Our results thus suggest that miR-326 negatively regulates CD155 expression in lung adenocarcinoma and might therefore play a role in the development of resistance to PD-1/PD-L1 inhibitors.

    DOI: 10.1111/cas.15921

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  • Comparison of Akt/mammalian target of rapamycin/4E-binding protein 1 pathway signal activation in round stromal and surface cells in patients with sclerosing pneumocytoma. International journal

    Mikiko Hashisako, Takeshi Iwasaki, Takamasa Matsumoto, Yuichi Yamada, Takumi Miyamoto, Midori Taniguchi, Chiemi Oishi, Yoshinao Oda

    Pathology, research and practice   244   154384 - 154384   2023.4   ISSN:0344-0338 eISSN:1618-0631

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    Sclerosing pneumocytoma (SP) is a rare benign epithelial tumor of the lung, and approximately 40 % of patients with SP present with AKT1 E17K mutation. SP cells comprise proliferated surface and round stromal cells. To elucidate the role of signal transductions and to identify the difference between surface and stromal cells, the current study aimed to investigate the activation of the Akt/mammalian target of rapamycin (mTOR)/4E-binding protein 1 signaling pathway in SP. METHODS: The molecular and pathological characteristics of SP in 12 patients were analyzed. AKT1 gene analysis revealed AKT1 E17K mutation in four cases. Immunohistochemical analysis revealed that tumor cells were cytoplasmic positive for pAkt, pmTOR, p4EBP1, and pS6RP. The surface cells had a significantly higher expression of pmTOR (p = 0.002) and a significantly lower expression of p4EBP1 (p = 0.017) than stromal cells. SP without AKT1 E17K mutation had a higher positive correlation with pacts, p4EBP1, pmTOR, and pS6RP expression than SP with AKT1 E17K mutation. These findings may be attributed to the aberrant activation of the Akt/mTOR pathway due to AKT1 E17K mutations. Hence, both surface and round stromal cells have tumorigenic characteristics, and differences in these characteristics may contribute to variations in tumor growth and the morphology and angiogenesis of SP.

    DOI: 10.1016/j.prp.2023.154384

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  • Association of thyroid transcription factor-1 (TTF-1) expression with efficacy of PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in advanced non-squamous non-small cell lung cancer. International journal

    Ritsu Ibusuki, Yasuto Yoneshima, Mikiko Hashisako, Norikazu Matsuo, Taishi Harada, Yuko Tsuchiya-Kawano, Junji Kishimoto, Keiichi Ota, Yoshimasa Shiraishi, Eiji Iwama, Kentaro Tanaka, Yoshinao Oda, Isamu Okamoto

    Translational lung cancer research   11 ( 11 )   2208 - 2215   2022.11   ISSN:2218-6751 eISSN:2226-4477

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    BACKGROUND: Thyroid transcription factor-1 (TTF-1) expression in advanced non-squamous non-small cell lung cancer (NSCLC) has been associated with the efficacy of pemetrexed plus platinum chemotherapy. However, the relation between TTF-1 expression and efficacy of the combination of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors plus pemetrexed and platinum chemotherapy, a standard first-line treatment regimen for advanced non-squamous NSCLC, has remained unclear. METHODS: We retrospectively evaluated TTF-1 expression in tumor tissue of patients with advanced or recurrent non-squamous NSCLC treated with PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in the first-line setting. Clinical characteristics and pathological data for each patient were assessed, and progression-free survival (PFS) was evaluated. Bias due to patient background was minimized by application of inverse probability of treatment weighting (IPTW) analysis. RESULTS: A total of 122 patients, 75 (61.5%) of whom were positive for TTF-1 immunostaining in tumor specimens, was included in this multicenter study. At the time of analysis, 89 (73.0%) patients had experienced progression events and 44 (36.1%) had died [median follow-up 14.6 months (range, 0.53-29.5 months)]. PFS was longer for TTF-1-positive patients than for TTF-1-negative patients [median, 12.2 vs. 6.0 months; hazard ratio (HR) =0.63 (95% CI: 0.37-1.06); log-rank P=0.028]. IPTW-adjusted PFS was significantly longer for TTF-1-positive than for TTF-1-negative patients [HR =0.62 (95% CI: 0.46-0.83); log-rank P=0.024]. CONCLUSIONS: TTF-1 expression in advanced non-squamous NSCLC can serve as a basis for prediction of PFS in patients treated with PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in the first-line setting.

    DOI: 10.21037/tlcr-22-393

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  • Biliary Microhamartoma in a Patient with Esophagogastric Junction Cancer That Resembled a Metastatic Liver Tumor and Significantly Influenced the Surgical Indication: Report of a Case

    Shimada Yuki, Ohuchida Kenoki, Matsumoto Takashi, Shindo Koji, Moriyama Taiki, Mizuuchi Yusuke, Nakata Kohei, Yamamoto Takeo, Hashisako Mikiko, Oda Yoshinao, Nakamura Masafumi

    The Japanese Journal of Gastroenterological Surgery   55 ( 5 )   311 - 316   2022.5   ISSN:03869768 eISSN:13489372

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    <p>A 69-year-old woman underwent surgery for esophagogastric junction cancer. Multiple subcapsular nodules of several millimeters in size were identified on the liver surface and diagnosed as liver metastases based on pathological examination. Staging laparoscopy was performed after 2 courses of chemotherapy and the same nodules were detected, but the pathological diagnosis was biliary microhamartoma. Finally, the patient underwent curative surgery. In this case, thermal effects of the ultrasonic energy device with an inadequate resection margin in the initial partial hepatectomy was a major obstacle to pathological diagnosis. In addition, the primary lesion was a well differentiated tumor without severe atypia, which could increase the difficulty in pathological diagnosis. This rare entity should be listed as a differential diagnosis of small nodules of the liver, especially when coexisting with gastrointestinal cancers. This report suggests the importance of obtaining a sufficient amount of liver specimens without thermal artifacts, since such artifacts may cause inappropriate identification of structural and morphological findings of tissue components, leading to diagnostic pitfalls.</p>

    DOI: 10.5833/jjgs.2021.0101

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  • 転移性肝腫瘍との鑑別が困難で手術適応の判断に影響した胆管過誤腫併存食道胃接合部癌の1例

    島田 有貴, 大内田 研宙, 松本 昂, 進藤 幸治, 森山 大樹, 水内 祐介, 仲田 興平, 山本 猛雄, 橋迫 美貴子, 小田 義直, 中村 雅史

    日本消化器外科学会雑誌   55 ( 5 )   311 - 316   2022.5   ISSN:0386-9768

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    症例は69歳の女性で,食道胃接合部癌に対する手術時に,肝被膜下に5mm弱の白色結節が散在していた.術中迅速診断で腺癌と診断されたため,手術適応外と判断した.化学療法を施行し,その後の審査腹腔鏡時に再度切除した組織で胆管過誤腫と診断され,後日改めて根治術を施行した.本症例は,初回手術時に採取した組織片が小さく,超音波凝固切開装置による熱変性による細胞の変形が,病理診断の大きな障害になったと考えられる.加えて,原発の食道胃接合部癌が高分化型であり,異型が比較的弱い病変であったことも一因といえる.消化器癌に併存した肝腫瘍の診断において,当疾患の存在も念頭におき,微小な病変であってもその組織構築や細胞形態の維持が不十分となり病理診断に影響しないように,アーチファクトが加わらない美麗な標本を十分量採取するよう心がけるべきである.(著者抄録)

  • Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases. International journal

    Yuichi Yamada, Izumi Kinoshita, Yoshiko Miyazaki, Yuki Tateishi, Yusuke Kuboyama, Takeshi Iwasaki, Kenichi Kohashi, Hidetaka Yamamoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yosuke Susuki, Kengo Kawaguchi, Mikiko Hashisako, Yui Yamada-Nozaki, Daisuke Kiyozawa, Taro Mori, Takeo Yamamoto, Kenji Tsuchihashi, Kazumi Kuriwaki, Munenori Mukai, Masataka Kawai, Keiko Suzuki, Hirotake Nishimura, Kenji Bando, Junya Masumoto, Mana Fukushima, Junichi Motoshita, Hiroki Mori, Akira Shiose, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   480 ( 4 )   919 - 925   2022.4   ISSN:0945-6317 eISSN:1432-2307

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    Intimal sarcoma is one of the most common and well-known primary malignant neoplasms of the aorta and heart. The authors reviewed cases of intimal sarcoma from histological, immunohistochemical and genetic perspectives. Twenty cases of intimal sarcoma were retrieved. Immunohistochemistry and FISH of MDM2 and PDGFRA genes were performed. All 20 tumours were composed of spindle-shaped, stellate, oval or polygonal tumour cells with irregular hyperchromatic nuclei arranged in a haphazard pattern, accompanied by nuclear pleomorphism and frequent mitotic figures. Other histological findings were as follows: abnormal mitosis in 10 cases (50%), necrosis in 15 cases (75%), myxoid stroma in 12 cases (60%), cartilaginous formation in 1 case (5%), haemorrhage in 12 cases (60%) and fibrinous deposition in 14 cases (70%). The tumours were positive for MDM2 in 16 cases (80%), ERG in 4 cases (20%), alpha-smooth muscle actin in 6 cases (30%), desmin in 5 cases (25%) and AE1/AE3 in 4 cases (20%). Immunohistochemical positivity was focal in each case. Loss of H3K27me3 expression was noted in 2 cases (10%). MDM2 and PDGFRA gene amplifications were detected in 11 cases (55%) and 1 case (5%), respectively. Fisher's exact test revealed a significant correlation between MDM2 gene amplification and myxoid stroma (p = 0.0194). No parameters showed any association with the anatomical location of the tumours. It was suggested that myxoid histology of intimal sarcoma may be associated with MDM2 gene amplification and that intimal sarcoma may be divided into myxoid and non-myxoid types.

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  • Idiopathic Pulmonary Fibrosis Complicated by Adenocarcinoma and Organizing Pneumonia

    Inutsuka, Y; Yanagihara, T; Matsumoto, K; Yoneda, R; Hashisako, M; Ogo, N; Asoh, T; Maeyama, T

    CUREUS JOURNAL OF MEDICAL SCIENCE   14 ( 1 )   e20916   2022.1   ISSN:2168-8184 eISSN:2168-8184

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  • Radiological pleuroparenchymal fibroelastosis-like lesion in idiopathic interstitial pneumonias. International journal

    Tomoyuki Fujisawa, Yasuoki Horiike, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Kensuke Kataoka, Mikiko Hashisako, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda

    Respiratory research   22 ( 1 )   290 - 290   2021.11

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    DOI: 10.1186/s12931-021-01892-9

  • Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution. International journal

    Yuki Tateishi, Yuichi Yamada, Masato Katsuki, Takuya Nagata, Hidetaka Yamamoto, Kenichi Kohashi, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Taro Mori, Yusuke Kuboyama, Ayumi Kakinokizono, Yoshiko Miyazaki, Aina Yamaguchi, Hiroyuki Tsutsui, Toshiharu Ninomiya, Hironobu Naiki, Yoshinao Oda

    Pathology, research and practice   227   153635 - 153635   2021.9

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    DOI: 10.1016/j.prp.2021.153635

  • Impact of Capicua on Pancreatic Cancer Progression. International journal

    Shohei Yoshiya, Shinji Itoh, Tomoharu Yoshizumi, Kyohei Yugawa, Takeshi Kurihara, Takeo Toshima, Noboru Harada, Mikiko Hashisako, Hirotoshi Yonemasu, Kengo Fukuzawa, Yoshinao Oda, Masaki Mori

    Annals of surgical oncology   28 ( 6 )   3198 - 3207   2021.6

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    DOI: 10.1245/s10434-020-09339-z

  • Histological background of dedifferentiated solitary fibrous tumour. International journal

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Journal of clinical pathology   75 ( 6 )   397 - 403   2021.5

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    DOI: 10.1136/jclinpath-2020-207311

  • Histological background of dedifferentiated solitary fibrous tumour. Invited Reviewed International journal

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Journal of clinical pathology   2021.5

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    DOI: 10.1136/jclinpath-2020-207311

  • Exposure to PM2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case-control study. International journal

    Masahiro Tahara, Yoshihisa Fujino, Kei Yamasaki, Keishi Oda, Takashi Kido, Noriho Sakamoto, Toshinori Kawanami, Kensuke Kataoka, Ryoko Egashira, Mikiko Hashisako, Yuzo Suzuki, Tomoyuki Fujisawa, Hiroshi Mukae, Takafumi Suda, Kazuhiro Yatera

    Respiratory research   22 ( 1 )   80 - 80   2021.3

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    DOI: 10.1186/s12931-021-01671-6

  • Exposure to PM 2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case-control study Reviewed International journal

    Masahiro Tahara, Yoshihisa Fujino, Kei Yamasaki, Keishi Oda, Takashi Kido, Noriho Sakamoto, Toshinori Kawanami, Kensuke Kataoka, Ryoko Egashira, Mikiko Hashisako, Yuzo Suzuki, Tomoyuki Fujisawa, Hiroshi Mukae, Takafumi Suda, Kazuhiro Yatera

    Respiratory Research   2021.3

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    DOI: 10.1186/s12931-021-01671-6

  • Computed tomography findings of current nonspecific interstitial pneumonia based on the 2013 updated classification of idiopathic interstitial pneumonias: What is a characteristic of previously diagnosed nonspecific interstitial pneumonia excluded from the updated classification.

    Junya Tominaga, Tae Iwasawa, Makiko Murota, Hiroaki Arakawa, Takeshi Johkoh, Yasuhiko Yamano, Yoshiaki Zaizen, Kazuya Ichikado, Mikiko Hashisako, Yasuhiro Kondoh, Kensuke Kataoka, Masaki Okamoto, Kiminori Fujimoto, Junya Fukuoka

    Japanese journal of radiology   39 ( 1 )   47 - 55   2021.1

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    DOI: 10.1007/s11604-020-01036-x

  • 特発性肺線維症における気管支肺胞洗浄液の予後予測に関する研究

    宮本 篤, 片岡 健介, 後藤 禎人, 江頭 玲子, 橋迫 美貴子, 近藤 康博, 中山 健夫, 穗積 宏尚, 藤澤 朋幸, 須田 隆文

    日本呼吸器学会誌   9 ( 増刊 )   302 - 302   2020.8

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  • Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.

    Midori Akagi, Masataka Umeda, Mikiko Hashisako, Kazusato Hara, Sousuke Tsuji, Yushiro Endo, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Daisuke Niino, Atsushi Kawakami

    Internal medicine (Tokyo, Japan)   59 ( 5 )   729 - 732   2020.3

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    DOI: 10.2169/internalmedicine.3626-19

  • Analysis of systemic lupus erythematosus-related interstitial pneumonia a retrospective multicentre study Reviewed International journal

    Noriyuki Enomoto, Ryoko Egashira, Kazuhiro Tabata, Mikiko Hashisako, Masashi Kitani, Yuko Waseda, Tamotsu Ishizuka, Satoshi Watanabe, Kazuo Kasahara, Shinyu Izumi, Akira Shiraki, Atsushi Miyamoto, Kazuma Kishi, Tomoo Kishaba, Chikatosi Sugimoto, Yoshikazu Inoue, Kensuke Kataoka, Yasuhiro Kondoh, Yutaka Tsuchiya, Tomohisa Baba, Hiroaki Sugiura, Tomonori Tanaka, Hiromitsu Sumikawa, Takafumi Suda

    Scientific reports   9 ( 1 )   7355 - 7355   2019.12

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    DOI: 10.1038/s41598-019-43782-7

  • Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis.

    Shiho Toyama, Ayuko Takatani, Tomohiro Koga, Mizuna Eguchi, Momoko Okamoto, Sosuke Tsuji, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Masako Furuyama, Maiko Tabuchi, Shinichiro Kobayashi, Kengo Kanetaka, Mikiko Hashisako, Kuniko Abe, Daisuke Niino, Shinya Sato, Yasushi Miyazaki, Atsushi Kawakami

    Internal medicine (Tokyo, Japan)   58 ( 22 )   3331 - 3336   2019.11

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    DOI: 10.2169/internalmedicine.2782-19

  • Clinicopathological review of solitary fibrous tumors dedifferentiation is a major cause of patient death Reviewed International journal

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Itou, Yutaka Koga, Mikiko Hashisako, Yui Nozaki, Daisuke Kiyozawa, Daichi Kitahara, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Yoshifumi Matsushita, Fumiyoshi Fushimi, Kenichi Taguchi, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Virchows Archiv   475 ( 4 )   467 - 477   2019.10

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    DOI: 10.1007/s00428-019-02622-9

  • Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion Reviewed International journal

    Tomoyuki Fujisawa, Kazutaka Mori, Masashi Mikamo, Takashi Ohno, Kensuke Kataoka, Chikatoshi Sugimoto, Hideya Kitamura, Noriyuki Enomoto, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Mikiko Hashisako, Tomonori Tanaka, Yasuhiro Terasaki, Shinobu Kunugi, Masashi Kitani, Ryo Okuda, Yasuoki Horiike, Yasunori Enomoto, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Yutaro Nakamura, Junya Fukuoka, Takeshi Johkoh, Yasuhiro Kondoh, Takashi Ogura, Yoshikazu Inoue, Yoshinori Hasegawa, Naohiko Inase, Sakae Homma, Takafumi Suda

    The European respiratory journal   53 ( 5 )   2019.5

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    DOI: 10.1183/13993003.02243-2018

  • Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement Comparison with EGFR mutation and ALK/EGFR-negative lung cancer Reviewed International journal

    Mio Mori, Hideyuki Hayashi, Minoru Fukuda, Sumihisa Honda, Takeshi Kitazaki, Kazuto Shigematsu, Naohiro Matsuyama, Mayumi Otsubo, Takeshi Nagayasu, Mikiko Hashisako, Kazuhiro Tabata, Masataka Uetani, Kazuto Ashizawa

    Thoracic Cancer   10 ( 4 )   872 - 879   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1759-7714.13017

  • Scarred organizing pneumonia (Cicatricial variant of cryptogenic organizing pneumonia)における臨床像の検討

    財前 圭晃, 黒田 揮志夫, 田畑 和宏, 橋迫 美貴子, 片岡 健介, 古山 和人, 白木 晶, 西村 浩一, 近藤 康博, 福岡 順也

    日本呼吸器学会誌   8 ( 増刊 )   198 - 198   2019.3

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  • Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks Reviewed International journal

    Yuri Tachibana, Hiroyuki Taniguchi, Yasuhiro Kondoh, Kensuke Kataoka, Naoki Hamada, Toshihiro Hashiguchi, Kazuya Ichikado, Tomoo Kishaba, Shuntaro Sato, Emiko Udo, Mikiko Hashisako, Junya Fukuoka

    Respiratory Investigation   57 ( 5 )   444 - 450   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resinv.2019.03.008

  • Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis Reviewed International journal

    Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao

    Photodiagnosis and Photodynamic Therapy   19   15 - 21   2017.9

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    DOI: 10.1016/j.pdpdt.2017.04.003

  • [Granuloma by Foreign Body Reaction to the Stapler Used for Partial Resection of the Lung].

    Shintaro Hashimoto, Naoya Yamasaki, Ryoichiro Doi, Go Hatachi, Ryoutaro Kamohara, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Mikiko Hashisako, Kazuhiro Tabata, Takeshi Nagayasu

    Kyobu geka. The Japanese journal of thoracic surgery   70 ( 3 )   187 - 190   2017.3

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  • 肺部分切除後ステープラー周囲肉芽腫

    橋本 慎太郎, 山崎 直哉, 土肥 良一郎, 畑地 豪, 蒲原 涼太郎, 宮崎 拓郎, 松本 桂太郎, 土谷 智史, 橋迫 美貴子, 田畑 和宏, 永安 武

    胸部外科   70 ( 3 )   187 - 190   2017.3

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    66歳女。胸部異常陰影を主訴とした。肺癌に対する肺部分切除後5年目のCTで右中葉のステープル近傍に腫瘤が出現し、約6ヵ月で増大傾向を示した。単純X線所見、胸部造影CT所見では右下肺野のステープル周囲に軽度の造影効果を伴う腫瘤性病変が描出され、PET-CT所見では腫瘤性病変にfluorodeoxyglucoseの集積を認めた。悪性を否定できず残存中葉を切除したところ、ステープル抜去部に一致して、緻密な線維性構造物を背景に多核巨細胞を含む類上皮細胞肉芽腫を認め、ステープルに対する異物反応を伴う肉芽腫と考えられた。術後6ヵ月、1年後のCTで腫瘤の形成は認めていない。本例は上中葉間不分葉のため肺瘻予防を優先してステープラーを使用したが、自動縫合器に関連した合併症としてステープル周囲肉芽腫も念頭に置き、術前のインフォームド・コンセントも含めて留意する必要があると考えられた。

  • Breakdown of lung framework and an increase in pores of kohn as initial events of emphysema and a cause of reduction in diffusing capacity Reviewed International journal

    Akira Yoshikawa, Shuntaro Sato, Tomonori Tanaka, Mikiko Hashisako, Yukio Kashima, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu, Hiroshi Yamamoto, Junya Fukuoka

    International Journal of COPD   11 ( 1 )   2287 - 2294   2016.9

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    DOI: 10.2147/COPD.S114281

  • Expression of CPOX and PEPT1 Is Associated With Detection of Upper Gastrointestinal Carcinomas By 5-Aminolevlinic Acid Induced-Photodynamic Diagnosis Reviewed

    Ogihara Kumi, Isomoto Hajime, Ishii Hiroyuki, Minami Hitomi, Akazawa Yuko, Yamaguchi Naoyuki, Ohnita Ken, Takeshima Fuminao, Hidaka Shigekazu, Matsushima Kayoko, Hashisako Mikiko, Tabata Kazuhiro, Nagayasu Takeshi, Fukuoka Junya, Nakao Kazuhiko

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB488 - AB488   2016.5

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    Expression of CPOX and PEPT1 Is Associated With Detection of Upper Gastrointestinal Carcinomas By 5-Aminolevlinic Acid Induced-Photodynamic Diagnosis

    DOI: 10.1016/j.gie.2016.03.687

  • A case of Sjögren's syndrome that was positive for anti-aminoacyl trna synthetase antibodies, indicating interstitial pneumonia with acute lung injury determined by surgical pulmonary biopsy

    74 ( 8 )   893 - 899   2015.8

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    A 77-year-old woman who had a one-month history of dyspnea and non-productive cough, as well as abnormal shadows on chest X-ray images, was referred to the Kyushu University Hospital, where chest CT scans showed interstitial pneumonia. Sjogren's syndrome was diagnosed following detection of anti-SS-A/Ro antibodies and histopathology of lip biopsy specimens. Histopathological analysis of lung biopsy specimens showed an acute lung injury that overlapped with chronic interstitial pneumonia, which is inconsistent with the typical lung pathology of Sjogren's syndrome. Subsequent analysis revealed the presence of anti-EJ antibodies, anti-aminoacyl tRNA synthetase antibodies associated with polymyositis/ dermatomyositis. These results suggest a rare over-lapping case of Sjogren's syndrome and antisynthe- Tase syndrome.

  • In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope Reviewed International journal

    Hajime Isomoto, Atsushi Nanashima, Takemasa Senoo, Kumi Ogiwara, Mikiko Hashisako, Ken Ohnita, Naoyuki Yamaguchi, Masaki Kunizaki, Shigekazu Hidaka, Hiroko Fukuda, Hiroyuki Ishii, Kayoko Matsushima, Hitomi Minami, Yuko Akazawa, Fuminao Takeshima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao

    Photodiagnosis and Photodynamic Therapy   12 ( 2 )   201 - 208   2015.6

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    DOI: 10.1016/j.pdpdt.2015.03.006

  • Flare phenomenon following gefitinib treatment of lung adenocarcinoma with bone metastasis.

    Mikiko Hashisako, Kentarou Wakamatsu, Satoshi Ikegame, Hiroyuki Kumazoe, Nobuhiko Nagata, Akira Kajiki

    The Tohoku journal of experimental medicine   228 ( 2 )   163 - 8   2012.10

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  • Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. International journal

    Satoshi Anai, Mikiko Hashisako, Satoshi Ikegame, Kentarou Wakamatsu, Nobuhiko Nagata, Yoichi Nakanishi, Akira Kajiki

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   18 ( 2 )   258 - 64   2012.4

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    DOI: 10.1007/s10156-011-0308-0

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Books

Presentations

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MISC

  • 【間質性肺炎診断の実際】膠原病およびその類縁の間質性肺炎

    橋迫 美貴子

    病理と臨床   41 ( 7 )   0718 - 0723   2023.7   ISSN:0287-3745

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  • 特発性間質性肺炎における胸部画像に基づくpleuroparenchymal fibroelastosis(PPFE)様所見の臨床的意義の探索

    堀池 安意, 藤澤 朋幸, 穗積 宏尚, 片岡 健介, 江頭 玲子, 橋迫 美貴子, 須田 隆文

    日本呼吸器学会誌   2020.8

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  • Scarred organizing pneumonia (Cicatricial variant of cryptogenic organizing pneumonia)における臨床像の検討

    財前 圭晃, 黒田 揮志夫, 田畑 和宏, 橋迫 美貴子, 片岡 健介, 古山 和人, 白木 晶, 西村 浩一, 近藤 康博, 福岡 順也

    日本呼吸器学会誌   2019.3

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  • Histological factors predicting exacerbation of interstitial pneumonia in patients with resected lung cancer

    Yukichika Yamamoto, Mikiko Hashisako, Kazuto Ashizawa, Tomoshi Tsuchiya, Noriho Sakamoto, Naoya Yamasaki, Yuji Ishimatsu, Takeshi Nagayasu, Junya Fukuoka

    MODERN PATHOLOGY   2018.3

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  • Histological factors predicting exacerbation of interstitial pneumonia in patients with resected lung cancer

    Yukichika Yamamoto, Mikiko Hashisako, Kazuto Ashizawa, Tomoshi Tsuchiya, Noriho Sakamoto, Naoya Yamasaki, Yuji Ishimatsu, Takeshi Nagayasu, Junya Fukuoka

    LABORATORY INVESTIGATION   2018.3

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  • Ciliated muconodular papillary tumorの1切除例

    濱本 琢朗, 畑地 豪, 小畑 智裕, 北村 由香, 蒲原 涼太郎, 宮崎 拓郎, 松本 桂太郎, 土谷 智史, 山崎 直哉, 永安 武, 橋迫 美貴子

    肺癌   2017.4

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  • Immune Profile of Ciliated Muconodular Papillary Tumors

    Emiko Udo, Sayuri Nakamura, Mikiko Hashisako, Junya Fukuoka

    MODERN PATHOLOGY   2017.2

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  • The Proposal of User-Friendly Formula to Separate CTD-IPs and IIPs

    Mutsumi Dairiki, Mikiko Hashisako, Shuntaro Sato, Kensuke Kataoka, Yasuhiro Kondoh, Hiroyuki Taniguchi, Hiromi Ichikawa, Junya Fukuoka

    MODERN PATHOLOGY   2017.2

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  • The Proposal of User-Friendly Formula to Separate CTD-IPs and IIPs

    Mutsumi Dairiki, Mikiko Hashisako, Shuntaro Sato, Kensuke Kataoka, Yasuhiro Kondoh, Hiroyuki Taniguchi, Hiromi Ichikawa, Junya Fukuoka

    LABORATORY INVESTIGATION   2017.2

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  • Immune Profile of Ciliated Muconodular Papillary Tumors

    Emiko Udo, Sayuri Nakamura, Mikiko Hashisako, Junya Fukuoka

    LABORATORY INVESTIGATION   2017.2

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  • 扁平上皮化生 通常型間質性肺炎における急性増悪の組織学的特徴と予後不良因子(Squamous metaplasia: Factor of acute exacerbation and poor prognosis in usual interstitial pneumonia)

    原 正武, 橋迫 美貴子, 山野 泰彦, 田中 伴典, 田畑 和宏, 上甲 剛, 近藤 康博, 谷口 博之, 福岡 順也

    日本病理学会会誌   2016.4

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  • 急性線維素性器質化肺炎とランゲルハンス細胞組織球増殖症が併発した1症例(A case of combined acute fibrinous and organizing pneumonia and Langerhans cell histiocytosis)

    石田 佳央理, 田中 伴典, 橋迫 美貴子, Groen Ruben, 角川 智之, 原 敦子, 坂本 憲穂, 福岡 順也

    日本病理学会会誌   2016.4

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  • Pathology of idiopathic interstitial pneumonias

    Mikiko Hashisako, Junya Fukuoka

    Clinical medicine insights. Circulatory, respiratory and pulmonary medicine   2016.2

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    DOI: 10.4137/CCRPM.S23320

  • Squamous Metaplasia: Indicator of Acute Exacerbation and Poor Prognostic Factor in Usual Interstitial Pneumonia

    Masatake Hara, Mikiko Hashisako, Yasuhiko Yamano, Takeshi Johkoh, Yasuhiro Kondoh, Hiroyuki Taniguchi, Junya Fukuoka

    MODERN PATHOLOGY   2016.2

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  • Squamous Metaplasia: Indicator of Acute Exacerbation and Poor Prognostic Factor in Usual Interstitial Pneumonia

    Masatake Hara, Mikiko Hashisako, Yasuhiko Yamano, Takeshi Johkoh, Yasuhiro Kondoh, Hiroyuki Taniguchi, Junya Fukuoka

    LABORATORY INVESTIGATION   2016.2

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  • Fluorescence Navigation of Gastric Tumors by 5-ALA Mediated Photodynamic Diagnosis With a LASER-Equipped Video Endoscope

    Kumi Ogihara, Hajime Isomoto, Takemasa Senoo, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Hitomi Minami, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao

    GASTROINTESTINAL ENDOSCOPY   2015.5

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  • 3D Pathology Construction Reveals Framework Structure of the Lung and Increase of Pores of Kohn as an Initial Event of Emphysema

    Akira Yoshikawa, Tomonori Tanaka, Mikiko Hashisako, Yukio Kashima, Hiroki Karata, Kazuhiro Tabata, Junya Fukuoka

    LABORATORY INVESTIGATION   2015.2

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  • 3D Pathology Construction Reveals Framework Structure of the Lung and Increase of Pores of Kohn as an Initial Event of Emphysema

    Akira Yoshikawa, Tomonori Tanaka, Mikiko Hashisako, Yukio Kashima, Hiroki Karata, Kazuhiro Tabata, Junya Fukuoka

    MODERN PATHOLOGY   2015.2

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  • 肺癌背景肺におけるMuc5B発現

    高畑 海音子, 橋迫 美貴子, 田中 伴典, 田畑 和宏, 加島 志郎, 山崎 直哉, 土谷 智史, 松本 桂太郎, 宮崎 拓郎, 永安 武, 福岡 順也

    肺癌   2014.10

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Professional Memberships

  • The International Academy of Pathology

  • Pulmonary Pathology Society

  • 日本肺癌学会

  • 日本呼吸器学会

  • 日本癌学会

  • 日本臨床細胞学会

  • 日本病理学会

  • 日本臨床細胞学会

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  • 日本肺癌学会

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  • 日本癌学会

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  • 日本病理学会

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  • 日本呼吸器学会

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  • The International Academy of Pathology

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  • Pulmonary Pathology Society

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Committee Memberships

  • Councilor   Domestic

    2023.4 - 2024.3   

  • 日本病理学会   学術評議員   Domestic

    2023.4 - 2024.3   

Research Projects

  • Overcoming acute exacerbation of interstitial lung diseases and progression of lung cancer by M2 macrophage inhibition

    Grant number:24K12016  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    CiNii Research

  • 空間的マルチオミクス解析による軟部肉腫の腫瘍微小環境の解明と代謝標的治療法の探索

    Grant number:23K27385  2023.4 - 2027.3

    科学研究費助成事業  基盤研究(B)

    小田 義直, 孝橋 賢一, 岩崎 健, 谷口 緑, 山本 猛雄, 橋迫 美貴子

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    Grant type:Scientific research funding

    骨軟部腫瘍の多くは、分化傾向に基づく診断分類が行われるが、病理診断困難例が多く予後不良である。申請者はこれまでに骨軟部肉腫における分子治療薬の標的となる癌シグナル経路の異常亢進と、これに誘導される複数の免疫チェックポイント分子の異常発現を明らかにした。しかし、軟部肉腫の腫瘍微小環境における物質代謝状態は未解明である。
    本研究では網羅的代謝物解析と複数の細胞特異的マーカーを高分解能で同時計測可能な次世代蛋白定量解析法を組み合わせ、空間的不均一性を1細胞レベルで網羅的に評価可能な「プロテオーム・メタボローム比較解析」を行い、新規診断バイオマーカーや新規治療標的となる代謝プロファイルを解明する。

    CiNii Research

Class subject

  • 臨床実習I

    2024.4 - 2025.3   Full year

  • 病理学(総論)

    2023.4 - 2023.9   First semester

  • 臨床腫瘍学の基本

    2021.10 - 2022.3   Second semester

  • 臨床実習I

    2021.4 - 2022.3   Full year

  • 病因と病態Ⅰ

    2021.4 - 2021.9   First semester

  • 3年次研究室配属(医学科・生命科学科)

    2021.4 - 2021.9   First semester

  • 臨床腫瘍学の基本

    2020.10 - 2021.3   Second semester

  • 臨床実習I

    2020.4 - 2021.3   Full year

  • 病因と病態Ⅰ

    2020.4 - 2020.9   First semester

  • 3年次研究室配属(医学科・生命科学科)

    2020.4 - 2020.9   First semester

  • 臨床実習

    2019.4 - 2020.3   Full year

  • 病理学総論

    2019.4 - 2019.9   First semester

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Specialized clinical area

  • Biological Sciences / Medicine, Dentistry and Pharmacy / Basic Medicine / Human Pathology

Year of medical license acquisition

  • 2008