2024/10/03 更新

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写真a

ハシサコ ミキコ
橋迫 美貴子
HASHISAKO MIKIKO
所属
九州大学病院 病理診断科・病理部 助教
医学部 医学科(併任)
医学系学府 医療経営・管理学専攻(併任)
職名
助教
プロフィール
【研究】びまん性肺疾患、肺腫瘍の病理組織学的及び分子生物学的解析 【教育】医学部生および大学院生の講義・実習 【社会連携】病理医不在地域に対する診断支援 診断困難例に対するコンサルテーション
外部リンク

研究テーマ・研究キーワード

  • 研究テーマ: 肺疾患の病理

    研究キーワード: 病理、肺疾患

    研究期間: 2013年4月

論文

  • Interobserver agreement of usual interstitial pneumonia diagnosis correlated with patient outcome 査読 国際誌

    Mikiko Hashisako, Tomonori Tanaka, Yasuhiro Terasaki, Toshimasa Uekusa, Rosane D. Achcar, Bassam I. Aswad, Hanaa S. Bamefleh, Vera L. Capelozzi, John C. English, Alexandre T. Fabro, Kensuke Kataoka, Tomayoshi Hayashi, Yasuhiro Kondoh, Hiroyuki Taniguchi, Junya Fukuoka

    Archives of Pathology and Laboratory Medicine   140 ( 12 )   1375 - 1382   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Context. - The histopathologic criteria for idiopathic pulmonary fibrosis were revised in the American Thoracic Society/European Respiratory Society/Japan Respiratory Society/Latin American Thoracic Association guidelines in 2011. However, the evidence of diagnosis based on the guidelines needs further investigation. Objective. - To examine whether the revised histopathologic criteria for idiopathic pulmonary fibrosis improved interobserver agreement among pathologists and the predicted prognosis in patients with interstitial pneumonia. Design. - Twenty, consecutive, surgical lung-biopsy specimens from cases of interstitial pneumonia were examined for histologic patterns by 11 pathologists without knowledge of clinical and radiologic data. Diagnosis was based on American Thoracic Society/European Respiratory Society guidelines of 2002 and 2011. Pathologists were grouped by cluster analysis, and interobserver agreement and association to the patient prognosis were compared with the diagnoses for each cluster. Results. - The generalized κ coefficient of diagnosis for all pathologists was 0.23. If the diagnoses were divided into 2 groups: usual interstitial pneumonia (UIP)/probable UIP (the UIP group) or possible/not UIP (the non-UIP group), according to the 2011 guidelines, the κ improved to 0.37. The pathologists were subdivided into 2 clusters in which 1 showed an association between UIP group diagnosis and patient prognosis (P < .05). Conclusions. - Agreement about pathologic diagnosis of interstitial pneumonia is low; however, results after division into UIP and non-UIP groups provided favorable agreement. The cluster analysis revealed 1 of the 2 clusters providing high interobserver agreement and prediction of patient prognosis.

    DOI: 10.5858/arpa.2016-0012-OA

  • Idiopathic dendriform pulmonary ossification as the phenotype of interstitial lung abnormalities: CT-pathologic correlation and prevalence

    Ueno, M; Egashira, R; Hashisako, M; Fujimoto, K; Fukuda, T; Hayashida, Y; Sumikawa, H; Tominaga, J; Tanaka, T; Terasaki, Y; Fukuoka, J; Nishioka, Y; Aoki, T; Gabata, T; Hatabu, H; Johkoh, T

    JAPANESE JOURNAL OF RADIOLOGY   42 ( 9 )   993 - 1002   2024年9月   ISSN:1867-1071 eISSN:1867-108X

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    記述言語:英語   出版者・発行元:Japanese Journal of Radiology  

    Background and purpose: Idiopathic dendriform pulmonary ossification (DPO) is mostly asymptomatic, and detected incidentally in lung CT. There have been no reports on the precise CT–pathologic correlation and the prevalence of idiopathic DPO. This study aimed to clarify the histological background and prevalence of idiopathic DPO. Materials and methods: Sixteen patients with histologically confirmed idiopathic DPO (12 men and 4 women; mean age, 38.8 years; range 22–56 years) were identified in a nationwide epidemiological survey. Local HRCT findings of pre-biopsy examinations, such as branching, round, linear structures with or without high attenuation were compared side by side with histological findings. The attenuation of branching, round, and linear structures was classified into three-point levels on bone window images (width, 2500 HU; level, 500 HU). Furthermore, we collected continuous pulmonary CT images of 8111 cases for checking up metastasis from extrathoracic malignancy at a single institution, and evaluated the prevalence of interstitial lung abnormalities (ILAs) and DPO. Results: In all 16 cases, branching (n = 15, 93%), round (n = 5, 31%), or linear (n = 5, 31%) structures were identified, histologically corresponding to dendriform ossification and cicatricial organizing pneumonia (OP)/fibrosis. Histologically, ossification was confirmed in all the 16 patients. However, in two cases, a highly attenuated structure could not be detected on the pre-biopsy CT of the same area. Regarding the prevalence of idiopathic DPO, 283 (3.5%) of 8111 patients had ILAs, of which a total of 26 (0.3% of all cases, 9.2% of ILAs cases) had DPO. Conclusion: Idiopathic DPO showed linear or branching structures with or without high attenuation on CT, corresponded to ossification, cicatricial OP/fibrosis. DPO was seen in 9.2% of ILAs cases. Idiopathic DPO is one of pathologic phenotypes of ILAs.

    DOI: 10.1007/s11604-024-01590-8

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  • Squamous metaplasia is an indicator of acute exacerbation in patients with usual interstitial pneumonia / idiopathic pulmonary fibrosis(タイトル和訳中)

    Tachibana Yuri, Hara Masatake, Hashisako Mikiko, Yamano Yasuhiko, Kataoka Kensuke, Kondoh Yasuhiro, Johkoh Takeshi, Morimoto Shimpei, Bychkov Andrey, Fukuoka Junya

    Respiratory Investigation   62 ( 4 )   631 - 637   2024年7月   ISSN:2212-5345

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    記述言語:英語   出版者・発行元:エルゼビア・ジャパン(株)  

  • Squamous metaplasia is an indicator of acute exacerbation in patients with usual interstitial pneumonia / idiopathic pulmonary fibrosis

    Tachibana Y., Hara M., Hashisako M., Yamano Y., Kataoka K., Kondoh Y., Johkoh T., Morimoto S., Bychkov A., Fukuoka J.

    Respiratory Investigation   62 ( 4 )   631 - 637   2024年7月   ISSN:22125345

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    出版者・発行元:Respiratory Investigation  

    Background: Acute exacerbation (AE) is a potentially lethal event in patients with usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF). However, to date, no pathological predictors of AE have been identified. This retrospective study aimed to elucidate the pathological features that could predict AE in patients with UIP. Methods: We reviewed the pathological findings of 91 patients with UIP/IPF and correlated these findings with AE events. Thirteen histological variables related to acute lung injury were evaluated by three independent observers and classified as positive or negative. The patients’ clinical data during follow-up were collected and reviewed for AE. A recursive partition using the Gini index for the prediction of AE was performed, with each pathological finding as a candidate for branching. Results: Twenty patients (22%) developed AE during the median follow-up duration of 40 months. Thirty-eight patients died (15 due to AE and 23 for other reasons). The median time interval from surgical lung biopsy to AE onset was 497 (interquartile range: 901–1657) days. Histologically, squamous metaplasia was positively associated with AE (odds ratio: 4.7, P = 0.015) and worse event-free survival in patients with UIP (P = 0.04). Leaf scoring based on the Gini index for recursive partition, including five positive findings (squamous metaplasia, neutrophilic infiltration, septal widening, Kuhn's hyaline, and fibrin), showed a sensitivity of 90% with a specificity of 74.7% (area under curve: 0.89). Conclusions: We found that squamous metaplasia is an important histopathological finding that predicts AE events and tends to unfavorable outcome in patients with UIP/IPF.

    DOI: 10.1016/j.resinv.2024.04.021

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  • Low-grade central osteosarcoma with extraosseous dedifferentiation: a rare case

    Kawaguchi, K; Kohashi, K; Sagiyama, K; Hashisako, M; Nabeshima, A; Setsu, N; Endo, M; Iwasaki, T; Nakashima, Y; Oda, Y

    SKELETAL RADIOLOGY   2024年3月   ISSN:0364-2348 eISSN:1432-2161

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    記述言語:英語   出版者・発行元:Skeletal Radiology  

    Low-grade central osteosarcoma (LGCOS), which arises from the intramedullary cavity of the metaphysis of long bones, occasionally exhibits extraosseous spread. Approximately 10–30% of patients with LGCOS exhibit dedifferentiation, but it is rare to experience a primary tumor with a dedifferentiated component. A 38-year-old female patient presented with right knee pain for two months. Imaging studies revealed a bone mass with extraosseous involvement. Wide resection was performed, and pathologic examination led to the diagnosis of LGCOS with a dedifferentiated extraosseous lesion. A single defect in the bone cortex constituted the boundary between the low- and high-grade components. The extraosseous high-grade component included more tumor cells with p53 overexpression and more murine double minute 2 (MDM2) copies compared with the low-grade component. These genetic mutations and copy number alterations can be associated with malignant transformation of LGCOS.

    DOI: 10.1007/s00256-024-04647-x

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  • Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma: A Case Report.

    Nakamura S, Takano T, Nakatsuru K, Tsubouchi K, Yamauchi T, Hashisako M, Iwasaki T, Okamoto I

    Internal medicine (Tokyo, Japan)   advpub ( 0 )   2024年   ISSN:09182918 eISSN:13497235

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    記述言語:英語   出版者・発行元:一般社団法人 日本内科学会  

    <p>Nodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL accompanied by interstitial pneumonia diagnosed via lung and lymph node biopsies. These findings suggest the need to rule out nTFHL before diagnosing IPAF. </p>

    DOI: 10.2169/internalmedicine.3601-24

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  • Stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities on CT

    Fukuda, T; Egashira, R; Ueno, M; Hashisako, M; Sumikawa, H; Tominaga, J; Yamada, D; Fukuoka, J; Misumi, S; Ojiri, H; Hatabu, H; Johkoh, T

    INSIGHTS INTO IMAGING   14 ( 1 )   177   2023年10月   ISSN:1869-4101

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    記述言語:英語   出版者・発行元:Insights into Imaging  

    High-attenuation pulmonary abnormalities are commonly seen on CT. These findings are increasingly encountered with the growing number of CT examinations and the wide availability of thin-slice images. The abnormalities include benign lesions, such as infectious granulomatous diseases and metabolic diseases, and malignant tumors, such as lung cancers and metastatic tumors. Due to the wide spectrum of diseases, the proper diagnosis of high-attenuation abnormalities can be challenging. The assessment of these abnormal findings requires scrutiny, and the treatment is imperative. Our proposed stepwise diagnostic algorithm consists of five steps. Step 1: Establish the presence or absence of metallic artifacts. Step 2: Identify associated nodular or mass-like soft tissue components. Step 3: Establish the presence of solitary or multiple lesions if identified in Step 2. Step 4: Ascertain the predominant distribution in the upper or lower lungs if not identified in Step 2. Step 5: Identify the morphological pattern, such as linear, consolidation, nodular, or micronodular if not identified in Step 4. These five steps to diagnosing high-attenuation abnormalities subdivide the lesions into nine categories. This stepwise radiologic diagnostic approach could help to narrow the differential diagnosis for various pulmonary high-attenuation abnormalities and to achieve a precise diagnosis. Critical relevance statement Our proposed stepwise diagnostic algorithm for high-attenuation pulmonary abnormalities may help to recognize a variety of those high-attenuation findings, to determine whether the associated diseases require further investigation, and to guide appropriate patient management. Key points • To provide a stepwise diagnostic approach to high-attenuation pulmonary abnormalities. • To familiarize radiologists with the varying cause of high-attenuation pulmonary abnormalities. • To recognize which high-attenuation abnormalities require scrutiny and prompt treatment. Graphical Abstract: [Figure not available: see fulltext.]

    DOI: 10.1186/s13244-023-01501-x

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  • 肺腺癌においてマイクロRNA-326はCD155発現を負に調節する(MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma)

    Nakanishi Takayuki, Yoneshima Yasuto, Okamura Koji, Yanagihara Toyoshi, Hashisako Mikiko, Iwasaki Takeshi, Haratake Naoki, Mizusaki Shun, Ota Keiichi, Iwama Eiji, Takenaka Tomoyoshi, Tanaka Kentaro, Yoshizumi Tomoharu, Oda Yoshinao, Okamoto Isamu

    Cancer Science   114 ( 10 )   4101 - 4113   2023年10月   ISSN:1347-9032

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    記述言語:英語   出版者・発行元:John Wiley & Sons Australia, Ltd  

    肺癌におけるCD155発現を転写後レベルで調節している可能性があるマイクロRNA(miR)の同定を試みた。標的予測プログラムを用いた網羅的miRスクリーニングを行い、さらに二重ルシフェラーゼレポーターアッセイを施行した。その結果、CD155 mRNAの3'-UTRに結合するmiRとして4種(miR-346、miR-328-3p、miR-326、miR-330-5p)が同定された。これらのmiRを複数の肺癌細胞株で強制発現させるとCD155の発現が抑制された。肺腺癌患者57名の組織検体でCD155を標的とする免疫組織化学解析を行った。その結果、CD155の腫瘍割合スコアの中央値は68%となった。これらの組織検体のうちCD155発現レベルが低い検体では高い検体よりもmiR-326が豊富に存在していた(p<0.005)。本研究結果から、肺腺癌ではmiR-326はCD155発現を負方向へ調節していることが示唆された。CD155発現の亢進はPD-1/PD-L1阻害剤耐性の機序になっていることから、miR-326はその耐性の出現に際して何らかの役割を果たしていると考えられた。

  • MicroRNA-326 negatively regulates CD155 expression in lung adenocarcinoma 国際誌

    Nakanishi, T; Yoneshima, Y; Okamura, K; Yanagihara, T; Hashisako, M; Iwasaki, T; Haratake, N; Mizusaki, S; Ota, K; Iwama, E; Takenaka, T; Tanaka, K; Yoshizumi, T; Oda, Y; Okamoto, I

    CANCER SCIENCE   114 ( 10 )   4101 - 4113   2023年8月   ISSN:1347-9032 eISSN:1349-7006

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Science  

    Treatment with immune checkpoint inhibitors induces a durable response in some patients with non-small-cell lung cancer, but eventually gives rise to drug resistance. Upregulation of CD155 expression is implicated as one mechanism of resistance to programmed death receptor-1 (PD-1)/PD-1 ligand (PD-L1) inhibitors, and it is therefore important to characterize the mechanisms underlying regulation of CD155 expression in tumor cells. The aim of this study was to identify microRNAs (miRNAs) that might regulate CD155 expression at the posttranscriptional level in lung cancer. Comprehensive miRNA screening with target prediction programs and a dual-luciferase reporter assay identified miR-346, miR-328-3p, miR-326, and miR-330-5p as miRNAs that bind to the 3'-UTR of CD155 mRNA. Forced expression of these miRNAs suppressed CD155 expression in lung cancer cell lines. Immunohistochemical staining of CD155 in tissue specimens from 57 patients with lung adenocarcinoma revealed the median tumor proportion score for CD155 to be 68%. The abundance of miR-326 in these specimens with a low level of CD155 expression was significantly greater than in specimens with a high level (p < 0.005). Our results thus suggest that miR-326 negatively regulates CD155 expression in lung adenocarcinoma and might therefore play a role in the development of resistance to PD-1/PD-L1 inhibitors.

    DOI: 10.1111/cas.15921

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  • Comparison of Akt/mammalian target of rapamycin/4E-binding protein 1 pathway signal activation in round stromal and surface cells in patients with sclerosing pneumocytoma 国際誌

    Hashisako, M; Iwasaki, T; Matsumoto, T; Yamada, Y; Miyamoto, T; Taniguchi, M; Oishi, C; Oda, Y

    PATHOLOGY RESEARCH AND PRACTICE   244   154384 - 154384   2023年4月   ISSN:0344-0338 eISSN:1618-0631

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Pathology Research and Practice  

    Sclerosing pneumocytoma (SP) is a rare benign epithelial tumor of the lung, and approximately 40 % of patients with SP present with AKT1 E17K mutation. SP cells comprise proliferated surface and round stromal cells. To elucidate the role of signal transductions and to identify the difference between surface and stromal cells, the current study aimed to investigate the activation of the Akt/mammalian target of rapamycin (mTOR)/4E-binding protein 1 signaling pathway in SP. METHODS: The molecular and pathological characteristics of SP in 12 patients were analyzed. AKT1 gene analysis revealed AKT1 E17K mutation in four cases. Immunohistochemical analysis revealed that tumor cells were cytoplasmic positive for pAkt, pmTOR, p4EBP1, and pS6RP. The surface cells had a significantly higher expression of pmTOR (p = 0.002) and a significantly lower expression of p4EBP1 (p = 0.017) than stromal cells. SP without AKT1 E17K mutation had a higher positive correlation with pacts, p4EBP1, pmTOR, and pS6RP expression than SP with AKT1 E17K mutation. These findings may be attributed to the aberrant activation of the Akt/mTOR pathway due to AKT1 E17K mutations. Hence, both surface and round stromal cells have tumorigenic characteristics, and differences in these characteristics may contribute to variations in tumor growth and the morphology and angiogenesis of SP.

    DOI: 10.1016/j.prp.2023.154384

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  • Association of thyroid transcription factor-1 (TTF-1) expression with efficacy of PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in advanced non-squamous non-small cell lung cancer 国際誌

    Ibusuki, R; Yoneshima, Y; Hashisako, M; Matsuo, N; Harada, T; Tsuchiya-Kawano, Y; Kishimoto, J; Ota, K; Shiraishi, Y; Iwama, E; Tanaka, K; Oda, Y; Okamoto, I

    TRANSLATIONAL LUNG CANCER RESEARCH   11 ( 11 )   2208 - 2215   2022年11月   ISSN:2218-6751 eISSN:2226-4477

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Translational Lung Cancer Research  

    BACKGROUND: Thyroid transcription factor-1 (TTF-1) expression in advanced non-squamous non-small cell lung cancer (NSCLC) has been associated with the efficacy of pemetrexed plus platinum chemotherapy. However, the relation between TTF-1 expression and efficacy of the combination of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors plus pemetrexed and platinum chemotherapy, a standard first-line treatment regimen for advanced non-squamous NSCLC, has remained unclear. METHODS: We retrospectively evaluated TTF-1 expression in tumor tissue of patients with advanced or recurrent non-squamous NSCLC treated with PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in the first-line setting. Clinical characteristics and pathological data for each patient were assessed, and progression-free survival (PFS) was evaluated. Bias due to patient background was minimized by application of inverse probability of treatment weighting (IPTW) analysis. RESULTS: A total of 122 patients, 75 (61.5%) of whom were positive for TTF-1 immunostaining in tumor specimens, was included in this multicenter study. At the time of analysis, 89 (73.0%) patients had experienced progression events and 44 (36.1%) had died [median follow-up 14.6 months (range, 0.53-29.5 months)]. PFS was longer for TTF-1-positive patients than for TTF-1-negative patients [median, 12.2 vs. 6.0 months; hazard ratio (HR) =0.63 (95% CI: 0.37-1.06); log-rank P=0.028]. IPTW-adjusted PFS was significantly longer for TTF-1-positive than for TTF-1-negative patients [HR =0.62 (95% CI: 0.46-0.83); log-rank P=0.024]. CONCLUSIONS: TTF-1 expression in advanced non-squamous NSCLC can serve as a basis for prediction of PFS in patients treated with PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in the first-line setting.

    DOI: 10.21037/tlcr-22-393

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  • 転移性肝腫瘍との鑑別が困難で手術適応の判断に影響した胆管過誤腫併存食道胃接合部癌の1例

    島田 有貴, 大内田 研宙, 松本 昂, 進藤 幸治, 森山 大樹, 水内 祐介, 仲田 興平, 山本 猛雄, 橋迫 美貴子, 小田 義直, 中村 雅史

    日本消化器外科学会雑誌   55 ( 5 )   311 - 316   2022年5月   ISSN:03869768 eISSN:13489372

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    記述言語:日本語   出版者・発行元:一般社団法人 日本消化器外科学会  

    <p>症例は69歳の女性で,食道胃接合部癌に対する手術時に,肝被膜下に5 mm弱の白色結節が散在していた.術中迅速診断で腺癌と診断されたため,手術適応外と判断した.化学療法を施行し,その後の審査腹腔鏡時に再度切除した組織で胆管過誤腫と診断され,後日改めて根治術を施行した.本症例は,初回手術時に採取した組織片が小さく,超音波凝固切開装置による熱変性による細胞の変形が,病理診断の大きな障害になったと考えられる.加えて,原発の食道胃接合部癌が高分化型であり,異型が比較的弱い病変であったことも一因といえる.消化器癌に併存した肝腫瘍の診断において,当疾患の存在も念頭におき,微小な病変であってもその組織構築や細胞形態の維持が不十分となり病理診断に影響しないように,アーチファクトが加わらない美麗な標本を十分量採取するよう心がけるべきである.</p>

    DOI: 10.5833/jjgs.2021.0101

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  • 転移性肝腫瘍との鑑別が困難で手術適応の判断に影響した胆管過誤腫併存食道胃接合部癌の1例

    島田 有貴, 大内田 研宙, 松本 昂, 進藤 幸治, 森山 大樹, 水内 祐介, 仲田 興平, 山本 猛雄, 橋迫 美貴子, 小田 義直, 中村 雅史

    日本消化器外科学会雑誌   55 ( 5 )   311 - 316   2022年5月   ISSN:0386-9768

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

    症例は69歳の女性で,食道胃接合部癌に対する手術時に,肝被膜下に5mm弱の白色結節が散在していた.術中迅速診断で腺癌と診断されたため,手術適応外と判断した.化学療法を施行し,その後の審査腹腔鏡時に再度切除した組織で胆管過誤腫と診断され,後日改めて根治術を施行した.本症例は,初回手術時に採取した組織片が小さく,超音波凝固切開装置による熱変性による細胞の変形が,病理診断の大きな障害になったと考えられる.加えて,原発の食道胃接合部癌が高分化型であり,異型が比較的弱い病変であったことも一因といえる.消化器癌に併存した肝腫瘍の診断において,当疾患の存在も念頭におき,微小な病変であってもその組織構築や細胞形態の維持が不十分となり病理診断に影響しないように,アーチファクトが加わらない美麗な標本を十分量採取するよう心がけるべきである.(著者抄録)

  • Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases 国際誌

    Yamada, Y; Kinoshita, I; Miyazaki, Y; Tateishi, Y; Kuboyama, Y; Iwasaki, T; Kohashi, K; Yamamoto, H; Ishihara, S; Toda, Y; Ito, Y; Susuki, Y; Kawaguchi, K; Hashisako, M; Yamada-Nozaki, Y; Kiyozawa, D; Mori, T; Yamamoto, T; Tsuchihashi, K; Kuriwaki, K; Mukai, M; Kawai, M; Suzuki, K; Nishimura, H; Bando, K; Masumoto, J; Fukushima, M; Motoshita, J; Mori, H; Shiose, A; Oda, Y

    VIRCHOWS ARCHIV   480 ( 4 )   919 - 925   2022年4月   ISSN:0945-6317 eISSN:1432-2307

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Virchows Archiv  

    Intimal sarcoma is one of the most common and well-known primary malignant neoplasms of the aorta and heart. The authors reviewed cases of intimal sarcoma from histological, immunohistochemical and genetic perspectives. Twenty cases of intimal sarcoma were retrieved. Immunohistochemistry and FISH of MDM2 and PDGFRA genes were performed. All 20 tumours were composed of spindle-shaped, stellate, oval or polygonal tumour cells with irregular hyperchromatic nuclei arranged in a haphazard pattern, accompanied by nuclear pleomorphism and frequent mitotic figures. Other histological findings were as follows: abnormal mitosis in 10 cases (50%), necrosis in 15 cases (75%), myxoid stroma in 12 cases (60%), cartilaginous formation in 1 case (5%), haemorrhage in 12 cases (60%) and fibrinous deposition in 14 cases (70%). The tumours were positive for MDM2 in 16 cases (80%), ERG in 4 cases (20%), alpha-smooth muscle actin in 6 cases (30%), desmin in 5 cases (25%) and AE1/AE3 in 4 cases (20%). Immunohistochemical positivity was focal in each case. Loss of H3K27me3 expression was noted in 2 cases (10%). MDM2 and PDGFRA gene amplifications were detected in 11 cases (55%) and 1 case (5%), respectively. Fisher's exact test revealed a significant correlation between MDM2 gene amplification and myxoid stroma (p = 0.0194). No parameters showed any association with the anatomical location of the tumours. It was suggested that myxoid histology of intimal sarcoma may be associated with MDM2 gene amplification and that intimal sarcoma may be divided into myxoid and non-myxoid types.

    DOI: 10.1007/s00428-022-03293-9

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  • Idiopathic Pulmonary Fibrosis Complicated by Adenocarcinoma and Organizing Pneumonia

    Inutsuka, Y; Yanagihara, T; Matsumoto, K; Yoneda, R; Hashisako, M; Ogo, N; Asoh, T; Maeyama, T

    CUREUS JOURNAL OF MEDICAL SCIENCE   14 ( 1 )   e20916   2022年1月   ISSN:2168-8184 eISSN:2168-8184

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  • Radiological pleuroparenchymal fibroelastosis-like lesion in idiopathic interstitial pneumonias. 国際誌

    Tomoyuki Fujisawa, Yasuoki Horiike, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Kensuke Kataoka, Mikiko Hashisako, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda

    Respiratory research   22 ( 1 )   290 - 290   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Pleuroparenchymal fibroelastosis (PPFE) is characterised by predominant upper lobe pleural and subpleural lung parenchymal fibrosis. Radiological PPFE-like lesion has been associated with various types of interstitial lung diseases. However, the prevalence and clinical significance of radiological PPFE-like lesion in patients with idiopathic interstitial pneumonias (IIPs) are not fully understood. We aimed to determine the prevalence and clinical impact on survival of radiological PPFE-like lesion in patients with IIPs. METHODS: A post-hoc analysis was conducted using data from the Japanese nationwide cloud-based database of patients with IIPs. All the patients in the database were diagnosed as having IIPs by multidisciplinary discussion. Patients diagnosed with idiopathic PPFE were excluded. Clinical data and chest computed tomography (CT) image of 419 patients with IIPs were analysed. The presence of radiological PPFE-like lesion was independently evaluated by two chest radiologists blind to the clinical data. RESULTS: Of the 419 patients with IIPs, radiological PPFE-like lesions were detected in 101 (24.1%) patients, mainly in idiopathic pulmonary fibrosis (IPF) and unclassifiable IIPs, but less in idiopathic nonspecific interstitial pneumonia. Prognostic analyses revealed that radiological PPFE-like lesion was significantly associated with poor outcome in patients with IIPs, which was independent of age, IPF diagnosis and %FVC. In survival analyses, the patients with radiological PPFE-like lesions had poor survival compared with those without (log-rank, p < 0.0001). Subgroup analyses demonstrated that radiological PPFE-like lesion was significantly associated with poor survival both in patients with IPF and those with unclassifiable IIPs. CONCLUSION: Radiological PPFE-like lesion is a condition that could exist in IIPs, mainly in IPF and unclassifiable IIPs. Importantly, the radiological PPFE-like lesion is a non-invasive marker to predict poor outcome in patients with IIPs, which should be carefully considered in clinical practice.

    DOI: 10.1186/s12931-021-01892-9

  • Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution. 国際誌

    Yuki Tateishi, Yuichi Yamada, Masato Katsuki, Takuya Nagata, Hidetaka Yamamoto, Kenichi Kohashi, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Taro Mori, Yusuke Kuboyama, Ayumi Kakinokizono, Yoshiko Miyazaki, Aina Yamaguchi, Hiroyuki Tsutsui, Toshiharu Ninomiya, Hironobu Naiki, Yoshinao Oda

    Pathology, research and practice   227   153635 - 153635   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Amyloidosis is a systemic or localized disease of protein deposition characterized by amorphous eosinophilic morphology and positivity of Congo Red staining. The typing of amyloidosis is becoming increasingly important because therapeutic agents for each amyloidosis type have been developed. Herein, the authors review the autopsy cases at an institution to reveal the putative Japanese characteristics of each amyloidosis type and evaluate the clinicopathological significance of each type. MATERIALS AND METHODS: A total of 131 autopsy cases of systemic and localized amyloidosis were retrieved for classification by immunohistochemistry. Immunohistochemistry for transthyretin, amyloid A (AA), immunoglobulin light-chain kappa and lambda, and β2-microglobulin was performed for all cases. RESULTS: The 131 amyloidosis cases were classified as follows: 71 cases (54.2%) of transthyretin amyloidosis, 32 cases (24.4%) of AA amyloidosis, 8 cases (6.1%) of light-chain amyloidosis, and 5 cases (3.8%) of β2-microglobulin amyloidosis, along with 15 equivocal cases (11.5%). All cases showed myocardial involvement of amyloidosis. Histopathologically, the transthyretin type was significantly associated with the interstitial and nodular patterns, and with the absence of the perivascular and endocardial patterns. The AA type was significantly associated with the perivascular and endocardial patterns, and with the absence of the nodular pattern. CONCLUSION: The authors revealed the putative characteristics of cardiac amyloidosis in Japan by using autopsy cases. About 90% of amyloidosis cases were successfully classified using only commercially available antibodies.

    DOI: 10.1016/j.prp.2021.153635

  • Impact of Capicua on Pancreatic Cancer Progression. 国際誌

    Shohei Yoshiya, Shinji Itoh, Tomoharu Yoshizumi, Kyohei Yugawa, Takeshi Kurihara, Takeo Toshima, Noboru Harada, Mikiko Hashisako, Hirotoshi Yonemasu, Kengo Fukuzawa, Yoshinao Oda, Masaki Mori

    Annals of surgical oncology   28 ( 6 )   3198 - 3207   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The transcription factor capicua (CIC) regulates mammalian development and homeostasis. Growing evidence shows that CIC suppresses various human cancers by directly repressing the downstream cancer-related target genes. This study investigated the clinical and biologic significance of CIC expression in pancreatic cancer (PC). METHODS: The study reviewed 132 patients with PC who underwent curative resection. The patients were divided into two groups according to CIC immunoreactivity score by immunohistochemistry, and the associations between CIC expression, clinicopathologic characteristics, and postoperative prognosis were investigated. Moreover, the influence of CIC expression on the malignant potential of PC cells was assessed with cell proliferation, motility assays, and use of quantitative real time-polymerase chain reaction and Western blot on the downstream target genes of CIC in knockdown experiments. RESULTS: The low-CIC expression group showed a higher proportion of lymphatic invasion (72.9% vs. 53.1%; p = 0.024), intrapancreatic neural invasion (94.1% vs. 81.3%; p = 0.021), and extrapancreatic plexus invasion (30.9% vs. 7.8%; p = 0.0006) than the high-CIC expression group as well as significantly worse overall survival (p = 0.0002) and recurrence-free survival (p = 0.0041) rates. Low CIC expression was an independent risk factor for poor prognosis (p = 0.038). Pancreatic cancer cells with knockdown CIC significantly enhanced cell motilities and cell cycle progression, promoted expression levels of ETV4 and MMP-9, and induced EMT. CONCLUSIONS: The study elucidated the association of low CIC expression with a poor prognosis for patients with PC and suggested that the CIC-ETV4-MMP-9 axis might control PC progression.

    DOI: 10.1245/s10434-020-09339-z

  • Histological background of dedifferentiated solitary fibrous tumour. 招待 査読 国際誌

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Journal of clinical pathology   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/jclinpath-2020-207311

  • Histological background of dedifferentiated solitary fibrous tumour. 国際誌

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yuki Kuma, Yui Yamada-Nozaki, Yutaka Koga, Mikiko Hashisako, Daisuke Kiyozawa, Daichi Kitahara, Fumiya Narutomi, Yusuke Kuboyama, Takahito Nakamura, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Fumiyoshi Fushimi, Kenichi Taguchi, Kenichi Nishiyama, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Journal of clinical pathology   75 ( 6 )   397 - 403   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Dedifferentiation is a histological phenomenon characterised by abrupt transition of histology to a sarcomatous component with high-grade malignant potential in solitary fibrous tumour (SFT). The authors histologically reviewed SFT cases to reveal the histological background of dedifferentiated SFTs. METHODS: Clinicopathological and histopathological findings of 145 SFT cases were reviewed. Immunohistochemical staining and genetic analysis were also performed. RESULTS: The non-dedifferentiated components showed a cellular component in 45 of 145 (31&#37;), high mitotic rate (≥4/10 high-powered field) in 12 of 145 (8.2&#37;) tumours, necrosis in 7 of 145 (4.8&#37;) tumours, multinodular growth pattern in 39 of 132 (29.5&#37;) available tumours and intratumoural fibrous septa in 37 of 131 (28.2&#37;). Immunohistochemically, the non-dedifferentiated components were positive for CD34 in 128 of 141 (90.7&#37;), bcl-2 in 101 of 133 (75.9&#37;), nuclear pattern of β-catenin in 64 of 127 (50.3&#37;) and p16 in 22 of 140 (15.7&#37;). Loss of Rb protein expression was detected in 17 of 110 (15.4&#37;) cases. Statistically, cellular component, multinodular structure, p16 overexpression and Rb protein loss were significantly associated with dedifferentiation. Moreover, cellular component and multinodular structure were significantly associated with p16 overexpression and Rb protein loss. All the non-deddifferentiated components showed wild type of p53 expression. The dedifferentiated components of all 10 dedifferentiated tumours presented positivity for p16 in 9 of 10 (90&#37;) and mutational type of p53 in 5 of 10 (50&#37;). Loss of Rb protein expression was detected in 6 of 10 (60&#37;). CONCLUSIONS: The authors propose that cellular or multinodular transformation may be associated with dedifferentiation. They also suggest that cellular and multinodular transformation may be associated with p16 overexpression and Rb downregulation.

    DOI: 10.1136/jclinpath-2020-207311

  • Exposure to PM 2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case-control study 査読 国際誌

    Masahiro Tahara, Yoshihisa Fujino, Kei Yamasaki, Keishi Oda, Takashi Kido, Noriho Sakamoto, Toshinori Kawanami, Kensuke Kataoka, Ryoko Egashira, Mikiko Hashisako, Yuzo Suzuki, Tomoyuki Fujisawa, Hiroshi Mukae, Takafumi Suda, Kazuhiro Yatera

    Respiratory Research   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12931-021-01671-6

  • Exposure to PM2.5 is a risk factor for acute exacerbation of surgically diagnosed idiopathic pulmonary fibrosis: a case-control study. 国際誌

    Masahiro Tahara, Yoshihisa Fujino, Kei Yamasaki, Keishi Oda, Takashi Kido, Noriho Sakamoto, Toshinori Kawanami, Kensuke Kataoka, Ryoko Egashira, Mikiko Hashisako, Yuzo Suzuki, Tomoyuki Fujisawa, Hiroshi Mukae, Takafumi Suda, Kazuhiro Yatera

    Respiratory research   22 ( 1 )   80 - 80   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Short-term exposure to ozone and nitrogen dioxide is a risk factor for acute exacerbation (AE) of idiopathic pulmonary fibrosis (AE-IPF). The comprehensive roles of exposure to fine particulate matter in AE-IPF remain unclear. We aim to investigate the association of short-term exposure to fine particulate matter with the incidence of AE-IPF and to determine the exposure-risk time window during 3 months before the diagnosis of AE-IPF. METHODS: IPF patients were retrospectively identified from the nationwide registry in Japan. We conducted a case-control study to assess the correlation between AE-IPF incidence and short-term exposure to eight air pollutants, including particulate matter < 2.5 µm (PM2.5). In the time-series data, we compared monthly mean exposure concentrations between months with AE (case months) and those without AE (control months). We used multilevel mixed-effects logistic regression models to consider individual and institutional-level variables, and also adjusted these models for several covariates, including temperature and humidity. An additional analysis with different monthly lag periods was conducted to determine the risk-exposure time window for 3 months before the diagnosis of AE-IPF. RESULTS: Overall, 152 patients with surgically diagnosed IPF were analyzed. AE-IPF was significantly associated with an increased mean exposure level of nitric oxide (NO) and PM2.5 30 days prior to AE diagnosis. Adjusted odds ratio (OR) with a 10 unit increase in NO was 1.46 [95% confidence interval (CI) 1.11-1.93], and PM2.5 was 2.56 (95% CI 1.27-5.15). Additional analysis revealed that AE-IPF was associated with exposure to NO during the lag periods lag 1, lag 2, lag 1-2, and lag 1-3, and PM2.5 during the lag periods lag 1 and lag 1-2. CONCLUSIONS: Our results show that PM2.5 is a risk factor for AE-IPF, and the risk-exposure time window related to AE-IPF may lie within 1-2 months before the AE diagnosis. Further investigation is needed on the novel findings regarding the exposure to NO and AE-IPF.

    DOI: 10.1186/s12931-021-01671-6

  • Computed tomography findings of current nonspecific interstitial pneumonia based on the 2013 updated classification of idiopathic interstitial pneumonias: What is a characteristic of previously diagnosed nonspecific interstitial pneumonia excluded from the updated classification.

    Junya Tominaga, Tae Iwasawa, Makiko Murota, Hiroaki Arakawa, Takeshi Johkoh, Yasuhiko Yamano, Yoshiaki Zaizen, Kazuya Ichikado, Mikiko Hashisako, Yasuhiro Kondoh, Kensuke Kataoka, Masaki Okamoto, Kiminori Fujimoto, Junya Fukuoka

    Japanese journal of radiology   39 ( 1 )   47 - 55   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To evaluate computed tomography (CT) findings of nonspecific interstitial pneumonia (NSIP) based on the current classification of idiopathic interstitial pneumonias (IIPs) and elucidate a characteristic of previously diagnosed NSIP excluded from the current classification. MATERIALS AND METHODS: The study included 74 patients with biopsy-proven NSIP (idiopathic NSIP [I-NSIP], 39 patients; NSIP associated with connective tissue disease [CTD-NSIP], 35 patients). Among patients who were compatible with the current classification of IIPs, 29 and 21 were categorized as having current I-NSIP and current CTD-NSIP, respectively. The remaining 24 patients were categorized as having previous I-NSIP or previous CTD-NSIP due to the primary pathologic diagnosis of cellular NSIP or associated findings of acute inflammatory changes. CT findings were evaluated and compared among the four groups. RESULTS: Current I-NSIP was indicated by ground-glass attenuation and reticulation with traction bronchiectasis/bronchiolectasis in predominantly peribronchovascular areas of the lower lung zone. The previous I-NSIP group tended to show broader airspace consolidation than the current I-NSIP group (p = 0.068). The previous CTD-NSIP group showed significantly broader airspace consolidation than the current I-NSIP group (p = 0.035). CONCLUSION: Broad airspace consolidation is a characteristic of previously diagnosed CTD-NSIP excluded from the current classification of IIPs.

    DOI: 10.1007/s11604-020-01036-x

  • 特発性肺線維症における気管支肺胞洗浄液の予後予測に関する研究

    宮本 篤, 片岡 健介, 後藤 禎人, 江頭 玲子, 橋迫 美貴子, 近藤 康博, 中山 健夫, 穗積 宏尚, 藤澤 朋幸, 須田 隆文

    日本呼吸器学会誌   9 ( 増刊 )   302 - 302   2020年8月

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    記述言語:日本語  

  • Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.

    Midori Akagi, Masataka Umeda, Mikiko Hashisako, Kazusato Hara, Sousuke Tsuji, Yushiro Endo, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Daisuke Niino, Atsushi Kawakami

    Internal medicine (Tokyo, Japan)   59 ( 5 )   729 - 732   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 54-year-old woman developed drop head syndrome (DHS), Raynaud's phenomenon and creatine kinase (CK) elevation. She did not meet the international classification criteria of dermatomyositis/polymyositis, as we observed no muscle weakness, grasping pain or electromyography abnormality in her limbs, and anti-aminoacyl tRNA synthetase (ARS) antibody was negative. Cervical magnetic resonance imaging and a muscle biopsy of the trapezius muscle revealed myositis findings as the only clinical observations in muscle. These findings, along with her anti-U1-ribonucleoprotein (RNP) antibody positivity and leukopenia, resulted in a diagnosis of mixed connective tissue disease (MCTD). Prednisolone treatment significantly improved her myositis. To our knowledge, this is the first report of DHS as the only muscle complication of MCTD.

    DOI: 10.2169/internalmedicine.3626-19

  • Analysis of systemic lupus erythematosus-related interstitial pneumonia a retrospective multicentre study 査読 国際誌

    Noriyuki Enomoto, Ryoko Egashira, Kazuhiro Tabata, Mikiko Hashisako, Masashi Kitani, Yuko Waseda, Tamotsu Ishizuka, Satoshi Watanabe, Kazuo Kasahara, Shinyu Izumi, Akira Shiraki, Atsushi Miyamoto, Kazuma Kishi, Tomoo Kishaba, Chikatosi Sugimoto, Yoshikazu Inoue, Kensuke Kataoka, Yasuhiro Kondoh, Yutaka Tsuchiya, Tomohisa Baba, Hiroaki Sugiura, Tomonori Tanaka, Hiromitsu Sumikawa, Takafumi Suda

    Scientific reports   9 ( 1 )   7355 - 7355   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6&#37;), followed by subacute (20.0&#37;), and acute IP (12.7&#37;). Radiologically, the most common HRCT pattern was “Unclassifiable” (54&#37;). Histologically, “Unclassifiable” was the most frequently found (41.7&#37;) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75&#37;). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.

    DOI: 10.1038/s41598-019-43782-7

  • Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis.

    Shiho Toyama, Ayuko Takatani, Tomohiro Koga, Mizuna Eguchi, Momoko Okamoto, Sosuke Tsuji, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Masako Furuyama, Maiko Tabuchi, Shinichiro Kobayashi, Kengo Kanetaka, Mikiko Hashisako, Kuniko Abe, Daisuke Niino, Shinya Sato, Yasushi Miyazaki, Atsushi Kawakami

    Internal medicine (Tokyo, Japan)   58 ( 22 )   3331 - 3336   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment.

    DOI: 10.2169/internalmedicine.2782-19

  • Clinicopathological review of solitary fibrous tumors dedifferentiation is a major cause of patient death 査読 国際誌

    Yuichi Yamada, Kenichi Kohashi, Izumi Kinoshita, Hidetaka Yamamoto, Takeshi Iwasaki, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yoshihiro Itou, Yutaka Koga, Mikiko Hashisako, Yui Nozaki, Daisuke Kiyozawa, Daichi Kitahara, Takeshi Inoue, Munenori Mukai, Yumi Honda, Gouji Toyokawa, Kenji Tsuchihashi, Yoshifumi Matsushita, Fumiyoshi Fushimi, Kenichi Taguchi, Sadafumi Tamiya, Yumi Oshiro, Masutaka Furue, Yasuharu Nakashima, Satoshi Suzuki, Toru Iwaki, Yoshinao Oda

    Virchows Archiv   475 ( 4 )   467 - 477   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Solitary fibrous tumor (SFT) is a soft-tissue neoplasm of intermediate malignant potential, presenting a wide histopathological spectrum. Poorer prognosis of hemangiopericytoma of the central nervous system (CNS), hypoglycemic SFT, and dedifferentiation are well-known characters of SFT, but their clinical significance were not demonstrated enough by large-sized study. Here, the clinicopathological features of SFTs are reviewed and the relationship between genetics and clinicopathological features is examined using 145 SFT cases. All cases were STAT6 IHC-positive and/or NAB2-STAT6 fusion gene-positive. Tumor location was classified into three categories: 30 pleuropulmonary, 96 non-pleuropulmonary/non-central nervous system (CNS), and 18 CNS tumors. The tumor developed recurrence in 21 of 93 available cases (22.5&#37;), metastasis in 11 of 93 (11.8&#37;), and tumor death in 9 of 93 (9.6&#37;). Hypoglycemia occurred in 2 primary tumors and 1 metastatic tumor among 63 reviewable cases, and dedifferentiation occurred in 10 cases (6.8&#37;) including 6 primary tumors, 2 recurrent tumors, and 2 metastatic tumors. Recurrence was positively associated with CNS location (p = 0.0109) and hypoglycemia (p = 0.001); metastasis was positively associated with CNS location (p = 0.0231), hypoglycemia (p < 0.0001), and dedifferentiation (p < 0.0001), while metastasis was negatively correlated with pleural location (p = 0.0471). Tumor death was positively associated with male sex (p = 0.0154), larger size (p = 0.0455), hypoglycemia (p < 0.0001), and dedifferentiation (p < 0.0001). Multivariate analysis revealed independent statistical significance of dedifferentiation for overall survival (p = 0.0467). Exon variant of the fusion gene had no statistical correlation with clinical outcome. In conclusion, dedifferentiation is a major prognostic factor of SFT, and specific location such as cerebromeningeal and intra-abdominal site and hypoglycemia also had a high risk for unfavorable prognosis.

    DOI: 10.1007/s00428-019-02622-9

  • Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion 査読 国際誌

    Tomoyuki Fujisawa, Kazutaka Mori, Masashi Mikamo, Takashi Ohno, Kensuke Kataoka, Chikatoshi Sugimoto, Hideya Kitamura, Noriyuki Enomoto, Ryoko Egashira, Hiromitsu Sumikawa, Tae Iwasawa, Shoichiro Matsushita, Hiroaki Sugiura, Mikiko Hashisako, Tomonori Tanaka, Yasuhiro Terasaki, Shinobu Kunugi, Masashi Kitani, Ryo Okuda, Yasuoki Horiike, Yasunori Enomoto, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Yutaro Nakamura, Junya Fukuoka, Takeshi Johkoh, Yasuhiro Kondoh, Takashi Ogura, Yoshikazu Inoue, Yoshinori Hasegawa, Naohiko Inase, Sakae Homma, Takafumi Suda

    The European respiratory journal   53 ( 5 )   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Multidisciplinary discussion (MDD) requiring close communication between specialists (clinicians, radiologists and pathologists) is the gold standard for the diagnosis of idiopathic interstitial pneumonias (IIPs). However, MDD by specialists is not always feasible because they are often separated by time and location. An online database would facilitate data sharing and MDD. Our aims were to develop a nationwide cloud-based integrated database containing clinical, radiological and pathological data of patients with IIPs along with a web-based MDD system, and to validate the diagnostic utility of web-based MDD in IIPs.Clinical data, high-resolution computed tomography images and lung biopsy slides from patients with IIPs were digitised and uploaded to separate servers to develop a cloud-based integrated database. Web-based MDD was performed using the database and video-conferencing to reach a diagnosis.Clinical, radiological and pathological data of 524 patients in 39 institutions were collected, uploaded and incorporated into the cloud-based integrated database. Subsequently, web-based MDDs with a pulmonologist, radiologist and pathologist using the database and video-conferencing were successfully performed for the 465 cases with adequate data. Overall, the web-based MDD changed the institutional diagnosis in 219 cases (47&#37;). Notably, the MDD diagnosis yielded better prognostic separation among the IIPs than did the institutional diagnosis.This is the first study of developing a nationwide cloud-based integrated database containing clinical, radiological and pathological data for web-based MDD in patients with IIPs. The database and the web-based MDD system that we built made MDD more feasible in practice, potentially increasing accurate diagnosis of IIPs.

    DOI: 10.1183/13993003.02243-2018

  • Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement Comparison with EGFR mutation and ALK/EGFR-negative lung cancer 査読 国際誌

    Mio Mori, Hideyuki Hayashi, Minoru Fukuda, Sumihisa Honda, Takeshi Kitazaki, Kazuto Shigematsu, Naohiro Matsuyama, Mayumi Otsubo, Takeshi Nagayasu, Mikiko Hashisako, Kazuhiro Tabata, Masataka Uetani, Kazuto Ashizawa

    Thoracic Cancer   10 ( 4 )   872 - 879   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: The study was conducted to evaluate the clinical and computed tomography (CT) findings of non-small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non-ALK/EGFR (no genetic abnormalities). Methods: We enrolled 201 patients with primary NSCLC who had undergone molecular testing for both ALK gene rearrangement and EGFR mutation. The clinical features and CT findings of the main lesion and associated pulmonary abnormalities were investigated. Results: Female gender (P = 0.0043 vs. non-ALK/EGFR), young age (P = 0.0156 vs. EGFR), and a light or never smoking history (P = 0.0039 vs. non-ALK/EGFR) were significant clinical characteristics of NSCLC with ALK gene rearrangement. The significant CT characteristics compared to NSCLC with EGFR mutation were a large mass (P = 0.0155), solid mass (P = 0.0048), and no air bronchogram (P = 0.0148). A central location (P = 0.0322) and lymphadenopathy (P = 0.0353) were also more frequently observed. Coexisting emphysema was significantly less frequent in NSCLC patients with ALK gene rearrangement (P = 0.0135) than non-ALK/EGFR. Conclusions: NSCLC with ALK gene rearrangement was more likely to develop in younger women with a light or never smoking history. The characteristic CT findings of NSCLC with ALK gene rearrangement were a large solid mass, less air bronchogram, a central location, and lymphadenopathy.

    DOI: 10.1111/1759-7714.13017

  • Scarred organizing pneumonia (Cicatricial variant of cryptogenic organizing pneumonia)における臨床像の検討

    財前 圭晃, 黒田 揮志夫, 田畑 和宏, 橋迫 美貴子, 片岡 健介, 古山 和人, 白木 晶, 西村 浩一, 近藤 康博, 福岡 順也

    日本呼吸器学会誌   8 ( 増刊 )   198 - 198   2019年3月

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    記述言語:日本語  

  • Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks 査読 国際誌

    Yuri Tachibana, Hiroyuki Taniguchi, Yasuhiro Kondoh, Kensuke Kataoka, Naoki Hamada, Toshihiro Hashiguchi, Kazuya Ichikado, Tomoo Kishaba, Shuntaro Sato, Emiko Udo, Mikiko Hashisako, Junya Fukuoka

    Respiratory Investigation   57 ( 5 )   444 - 450   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Pulmonary interstitial emphysema is a rare, abnormal condition in which air pressure from the alveolar airspace tears the adjacent interstitial tissues of the lung and causes the formation of cystic spaces. Pulmonary interstitial emphysema is a known indication for mechanical ventilation in premature infants with neonatal respiratory distress syndrome, and it can be observed in various types of interstitial lung disease. Nevertheless, its pathogenesis and clinical impact remain unknown. Methods: We reviewed data from 433 cases of interstitial lung disease from an external consultation archive. Multidisciplinary diagnosis along with clinical and follow-up data, including events of air leaks such as pneumothorax and mediastinal emphysema, were obtained and compared to those of 150 control cases of interstitial lung disease without pulmonary interstitial emphysema. Results: We found 22 (5.1&#37;)cases of interstitial lung disease with pulmonary interstitial emphysema. The diagnoses included idiopathic pulmonary fibrosis (5/22 [22.7&#37;]), pleuroparenchymal fibroelastosis (4/22 [18.2&#37;]), chronic hypersensitivity pneumonia (4/22 [18.2&#37;]), and others (9/22 [40.9&#37;]). Cases involving pulmonary interstitial emphysema demonstrated a significantly higher frequency of air leaks than did those without pulmonary interstitial emphysema (12/22 [54.5&#37;]versus 23/150 [15.3&#37;]; P < 0.001; odds ratio, 6.63)and were associated with worse prognosis (P = 0.009 [log-rank])and a lower median percent forced vital capacity (73.2&#37; versus 84.0&#37;; P < 0.001). Conclusions: We found that pulmonary interstitial emphysema is an independent factor for poor prognosis, which also shows a trend to cause air leaks, including pneumothorax and mediastinal emphysema.

    DOI: 10.1016/j.resinv.2019.03.008

  • Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis 査読 国際誌

    Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao

    Photodiagnosis and Photodynamic Therapy   19   15 - 21   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer. Methods Aminolevulinic acid-mediated photodynamic diagnosis was performed in 23 lesions from 20 patients using an endoscope equipped with a blue laser light that caused red fluorescence emission of photosensitizing protoporphyrin IX. Red fluorescence signal and intensity was assessed during photodynamic diagnosis procedures. Lesions were resected by endoscopic and/or laparoscopic surgery, and specimens were immunostained and assessed for the expression of ATP-binding cassette sub-family G member 2, oligopeptide transporter-1, and coproporphyrinogen oxidase. Results Photodynamic diagnosis was negative in four cases (17.4&#37;). Three cases of photodynamic diagnosis-negative lesions were signet-ring cell carcinomas, and only one case was differentiated adenocarcinoma (intestinal type). Twenty intestinal type, photodynamic diagnosis-positive lesions showed high expression of coproporphyrinogen oxidase, whereas signet-ring cell carcinomas were all negative. Oligopeptide transporter-1 immunoreactivity was significantly higher in tumors of intestinal type. ATP-binding cassette sub-family G member 2 expression tended to be higher in luminal surface tumors than in intestinal type tumors. Conclusion Aminolevulinic acid-mediated photodynamic diagnosis provided good detection of upper gastrointestinal tumors of intestinal type but not diffuse type tumors, such as signet-ring cell carcinomas, possibly owing to coproporphyrinogen oxidase expression.

    DOI: 10.1016/j.pdpdt.2017.04.003

  • [Granuloma by Foreign Body Reaction to the Stapler Used for Partial Resection of the Lung].

    Shintaro Hashimoto, Naoya Yamasaki, Ryoichiro Doi, Go Hatachi, Ryoutaro Kamohara, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Mikiko Hashisako, Kazuhiro Tabata, Takeshi Nagayasu

    Kyobu geka. The Japanese journal of thoracic surgery   70 ( 3 )   187 - 190   2017年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    A 66-year-old woman underwent right lower lobectomy and partial resection of the middle lobe for Stage I A double lung cancer. Five years after the operation, a routine computed tomography (CT) scan showed a mass on the staple line at the middle lobe. The mass was enlarged on CT scan after 6 months. A definitive diagnosis could not be made by bronchoscopic examination and fluoro-2-deoxy-glucose(FDG)/positron emission tomography( PET)-CT showed FDG uptake in the mass( early phase:SUVmax=3.24, late phase:SUVmax=4.31). Local recurrence of lung cancer was not completely denied, and right middle lobectomy was performed. Histopathologically, the resected specimen revealed granuloma with foreign body reaction. We should keep in mind the possibility of granuloma as differential diagnosis of lung cancer when using stapler.

  • 肺部分切除後ステープラー周囲肉芽腫

    橋本 慎太郎, 山崎 直哉, 土肥 良一郎, 畑地 豪, 蒲原 涼太郎, 宮崎 拓郎, 松本 桂太郎, 土谷 智史, 橋迫 美貴子, 田畑 和宏, 永安 武

    胸部外科   70 ( 3 )   187 - 190   2017年3月

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    記述言語:日本語  

    66歳女。胸部異常陰影を主訴とした。肺癌に対する肺部分切除後5年目のCTで右中葉のステープル近傍に腫瘤が出現し、約6ヵ月で増大傾向を示した。単純X線所見、胸部造影CT所見では右下肺野のステープル周囲に軽度の造影効果を伴う腫瘤性病変が描出され、PET-CT所見では腫瘤性病変にfluorodeoxyglucoseの集積を認めた。悪性を否定できず残存中葉を切除したところ、ステープル抜去部に一致して、緻密な線維性構造物を背景に多核巨細胞を含む類上皮細胞肉芽腫を認め、ステープルに対する異物反応を伴う肉芽腫と考えられた。術後6ヵ月、1年後のCTで腫瘤の形成は認めていない。本例は上中葉間不分葉のため肺瘻予防を優先してステープラーを使用したが、自動縫合器に関連した合併症としてステープル周囲肉芽腫も念頭に置き、術前のインフォームド・コンセントも含めて留意する必要があると考えられた。

  • Breakdown of lung framework and an increase in pores of kohn as initial events of emphysema and a cause of reduction in diffusing capacity 査読 国際誌

    Akira Yoshikawa, Shuntaro Sato, Tomonori Tanaka, Mikiko Hashisako, Yukio Kashima, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu, Hiroshi Yamamoto, Junya Fukuoka

    International Journal of COPD   11 ( 1 )   2287 - 2294   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose: Pulmonary emphysema is the pathological prototype of chronic obstructive pulmonary disease and is also associated with other lung diseases. We considered that observation with different approaches may provide new insights for the pathogenesis of emphysema. Patients and methods: We reviewed tissue blocks of the lungs of 25 cases with/without emphysema and applied a three-dimensional observation method to the blocks. Based on the three-dimensional characteristics of the alveolar structure, we considered one face of the alveolar polyhedron as a structural unit of alveoli and called it a framework unit (FU). We categorized FUs based on their morphological characteristics and counted their number to evaluate the destructive changes in alveoli. We also evaluated the number and the area of pores of Kohn in FUs. We performed linear regression analysis to estimate the effect of these data on pulmonary function tests. Results: In multivariable regression analysis, a decrease in the number of FUs without an alveolar wall led to a significant decrease in the diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO per unit alveolar volume, and an increase in the area of pores of Kohn had a significant effect on an increase in residual capacity. Conclusion: A breakdown in the lung framework and an increase in pores of Kohn are associated with a decrease in DLCO and DLCO per unit alveolar volume with/without emphysema.

    DOI: 10.2147/COPD.S114281

  • Expression of CPOX and PEPT1 Is Associated With Detection of Upper Gastrointestinal Carcinomas By 5-Aminolevlinic Acid Induced-Photodynamic Diagnosis 査読

    Ogihara Kumi, Isomoto Hajime, Ishii Hiroyuki, Minami Hitomi, Akazawa Yuko, Yamaguchi Naoyuki, Ohnita Ken, Takeshima Fuminao, Hidaka Shigekazu, Matsushima Kayoko, Hashisako Mikiko, Tabata Kazuhiro, Nagayasu Takeshi, Fukuoka Junya, Nakao Kazuhiko

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB488 - AB488   2016年5月

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    記述言語:英語  

    Expression of CPOX and PEPT1 Is Associated With Detection of Upper Gastrointestinal Carcinomas By 5-Aminolevlinic Acid Induced-Photodynamic Diagnosis

    DOI: 10.1016/j.gie.2016.03.687

  • A case of Sjögren's syndrome that was positive for anti-aminoacyl trna synthetase antibodies, indicating interstitial pneumonia with acute lung injury determined by surgical pulmonary biopsy

    Kentaro Tamura, Naoki Hamada, Saiko Ogata, Miyoko Tatsuta, Tatsuro Okamoto, Kayo Ijichi, Mikiko Hashisako, Junya Fukuoka, Koichiro Matsumoto, Koichi Takayama, Yoichi Nakanishi

    Japanese Journal of Chest Diseases   74 ( 8 )   893 - 899   2015年8月

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    記述言語:その他   掲載種別:研究論文(学術雑誌)  

    A 77-year-old woman who had a one-month history of dyspnea and non-productive cough, as well as abnormal shadows on chest X-ray images, was referred to the Kyushu University Hospital, where chest CT scans showed interstitial pneumonia. Sjogren's syndrome was diagnosed following detection of anti-SS-A/Ro antibodies and histopathology of lip biopsy specimens. Histopathological analysis of lung biopsy specimens showed an acute lung injury that overlapped with chronic interstitial pneumonia, which is inconsistent with the typical lung pathology of Sjogren's syndrome. Subsequent analysis revealed the presence of anti-EJ antibodies, anti-aminoacyl tRNA synthetase antibodies associated with polymyositis/ dermatomyositis. These results suggest a rare over-lapping case of Sjogren's syndrome and antisynthe- Tase syndrome.

  • In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope 査読 国際誌

    Hajime Isomoto, Atsushi Nanashima, Takemasa Senoo, Kumi Ogiwara, Mikiko Hashisako, Ken Ohnita, Naoyuki Yamaguchi, Masaki Kunizaki, Shigekazu Hidaka, Hiroko Fukuda, Hiroyuki Ishii, Kayoko Matsushima, Hitomi Minami, Yuko Akazawa, Fuminao Takeshima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao

    Photodiagnosis and Photodynamic Therapy   12 ( 2 )   201 - 208   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Photodynamic diagnosis (PDD) is an imaging technology that is based on the fundamental biological features of cancer cells. Five-aminolevulinic acid (ALA), a precursor of photosensitizing protoporphyrin IX (PpIX) has been applied. In fact, ALA-mediated PDD provides good visualization for certain tumors. However, there have been few studies on clinical application of PDD for gastrointestinal (GI) cancers. This study was aimed to investigate the feasibility of ALA-mediated PDD for navigation of upper GI tumors. Materials and methods: Using a newly developed endoscope equipped with a blue laser light excitation, ALA-mediated PDD was conducted in 27 lesions from 23 patients with upper GI tumors including 2 Barrett's intramucosal cancers. ALA solution was given orally 3. h before PDD. All the adenocarcinomas came under clinical stage I, and the tumors were resected endoscopic submucosal dissection and/or laparoscopic surgery. Red fluorescence signal and intensity was assessed as for clinicopathological features of the cases. Results: The laser-based endoscopy could detect upper GI tumors as red fluorescent navigation (PDD-positive) in 23 of the 27 lesions. All but one intestinal typed tumors in histopathology were significantly PDD-positive, whereas each signet ring cell carcinoma was PDD-negative. There was a significant difference in tumor size between the PDD-positive and -negative tumors. The elevated lesions emitted significantly more intense fluorescence. Conclusions: Fluorescence navigation by ALA-mediated PDD provided sufficient detection of upper GI tumors in particular for the intestinal typed tumors. Thus, ALA-PDD using the blue laser-equipped endoscope offers a promising diagnostic tool.

    DOI: 10.1016/j.pdpdt.2015.03.006

  • Flare phenomenon following gefitinib treatment of lung adenocarcinoma with bone metastasis.

    Mikiko Hashisako, Kentarou Wakamatsu, Satoshi Ikegame, Hiroyuki Kumazoe, Nobuhiko Nagata, Akira Kajiki

    The Tohoku journal of experimental medicine   228 ( 2 )   163 - 8   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The skeleton is the most common site for distant metastasis in patients with cancer. To detect bone metastasis and evaluate the efficacy of treatment, we usually use bone scintigraphy and check serum alkaline phosphatase (ALP). However, such evaluation is sometimes difficult due to flare phenomenon. A 61-year-old male was referred to our department with a suspected diagnosis of lung cancer. Following thorough examinations, he was diagnosed with primary lung cancer (adenocarcinoma, Stage IV) and found to have a mutation in the epidermal growth factor receptor gene at exon 21 (L858R). After initiating treatment with oral gefitinib, ALP increased and peaked at 3,592 U/L by 3 weeks and decreased thereafter. At 4 weeks following treatment initiation, bone scintigraphy revealed a marked increase in abnormal accumulation of (99m)Tc-polyphosphate, but the primary tumor and metastases in regions other than the bone were reduced. At 9 weeks after treatment initiation, abnormal accumulations was improved in bone scintigraphy, and computed tomography revealed osteoblastic changes consistent with the accumulated lesion observed by bone scintigraphy. After initiating cancer treatment for bone metastasis, it is not uncommon to observe transient asynchronous accumulation in bone scintigraphy or transient increases in ALP in patients who ultimately respond to the treatment. These changes are called flare phenomenon, and documented in patients with prostate cancer or breast cancer receiving treatment. When determining the efficacy of treatments that target carcinomas with bone metastases, it is important to note that flare phenomenon is often indistinguishable from disease progression indicators.

  • Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. 国際誌

    Satoshi Anai, Mikiko Hashisako, Satoshi Ikegame, Kentarou Wakamatsu, Nobuhiko Nagata, Yoichi Nakanishi, Akira Kajiki

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   18 ( 2 )   258 - 64   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 78-year-old Japanese woman was admitted to our hospital for fever, dry cough, and right pleural effusion. She was diagnosed with mantle cell lymphoma (MCL) at 73 years of age and was treated with carcinostatics, but MCL was refractory. Chest computed tomography (CT) on admission revealed a localized trabecular shadow in the middle lobe of the right lung and right pleural effusion with thickened visceral pleura. Right pleural effusion was exudative, lymphocytes were dominant, and adenosine deaminase isoenzymes were elevated. (18)F-fluorodeoxyglucose positron emission tomography/CT revealed positive findings in the right thickened visceral pleura and right middle lobe. We suspected tuberculosis, but bronchoscopy revealed that the washing fluid was negative for Ziehl-Neelsen staining. Thoracoscopy under local anesthesia revealed redness on the parietal and visceral pleura and fibrin network. Pathological findings from pleural biopsy included granulomas, Langhans-type giant cells, and diffuse invasion of lymphocytes with atypical nuclei. Immunophenotypes were CD5(+), CD10(-), CD19(+), CD20(+), λ(+), CD25(+) by flow cytometry and CD20(+), CD45RO(-), cyclin D1(+), bcl2(+), bcl6(-) by immunohistochemistry. We diagnosed MCL involvement of the pleura, and highly suspected tuberculous pleurisy. The patient received antituberculosis therapy with rifampicin, isoniazid, pyrazinamide, and ethambutol. After 4 weeks, culture of bronchoscopy washing fluid was positive for Mycobacterium tuberculosis. We diagnosed pulmonary tuberculosis. Patients with malignant lymphoma are vulnerable to tuberculosis. In addition to diagnosing MCL involvement of the pleura, it is important to consider the possibility of complication with tuberculosis.

    DOI: 10.1007/s10156-011-0308-0

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書籍等出版物

  • Chronic Diffuse Lung Diseases

    Mikiko Hashisako, Junya Fukuoka, Maxwell L. Smith

    Elsevier  2017年10月 

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    記述言語:英語  

    Chronic diffuse lung diseases involve a spectrum of nonneoplastic inflammatory conditions that affect the lung parenchyma. This chapter reviews the spectrum of disease including idiopathic interstitial pneumonias, pulmonary manifestations of systemic collagen vascular disease, diffuse eosinophilc lung disease, drug-associated lung disease, diffuse granulomatous lung disease, and a variety of miscellaneous diseases that defy classification. Individual entities are reviewed, followed by a section highlighting a practical approach to the four most common patterns of injury encountered in practice.

    DOI: 10.1016/B978-0-323-44284-8.00008-9

講演・口頭発表等

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MISC

  • 【間質性肺炎診断の実際】膠原病およびその類縁の間質性肺炎

    橋迫 美貴子

    病理と臨床   41 ( 7 )   0718 - 0723   2023年7月   ISSN:0287-3745

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    記述言語:日本語   出版者・発行元:(株)文光堂  

  • 特発性間質性肺炎における胸部画像に基づくpleuroparenchymal fibroelastosis(PPFE)様所見の臨床的意義の探索

    堀池 安意, 藤澤 朋幸, 穗積 宏尚, 片岡 健介, 江頭 玲子, 橋迫 美貴子, 須田 隆文

    日本呼吸器学会誌   2020年8月

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    記述言語:日本語  

  • Scarred organizing pneumonia (Cicatricial variant of cryptogenic organizing pneumonia)における臨床像の検討

    財前 圭晃, 黒田 揮志夫, 田畑 和宏, 橋迫 美貴子, 片岡 健介, 古山 和人, 白木 晶, 西村 浩一, 近藤 康博, 福岡 順也

    日本呼吸器学会誌   2019年3月

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    記述言語:日本語  

    Scarred organizing pneumonia (Cicatricial variant of cryptogenic organizing pneumonia)における臨床像の検討

  • Histological factors predicting exacerbation of interstitial pneumonia in patients with resected lung cancer

    Yukichika Yamamoto, Mikiko Hashisako, Kazuto Ashizawa, Tomoshi Tsuchiya, Noriho Sakamoto, Naoya Yamasaki, Yuji Ishimatsu, Takeshi Nagayasu, Junya Fukuoka

    MODERN PATHOLOGY   2018年3月

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    記述言語:英語  

  • Histological factors predicting exacerbation of interstitial pneumonia in patients with resected lung cancer

    Yukichika Yamamoto, Mikiko Hashisako, Kazuto Ashizawa, Tomoshi Tsuchiya, Noriho Sakamoto, Naoya Yamasaki, Yuji Ishimatsu, Takeshi Nagayasu, Junya Fukuoka

    LABORATORY INVESTIGATION   2018年3月

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    記述言語:英語  

  • Ciliated muconodular papillary tumorの1切除例

    濱本 琢朗, 畑地 豪, 小畑 智裕, 北村 由香, 蒲原 涼太郎, 宮崎 拓郎, 松本 桂太郎, 土谷 智史, 山崎 直哉, 永安 武, 橋迫 美貴子

    肺癌   2017年4月

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    記述言語:日本語  

    Ciliated muconodular papillary tumorの1切除例

  • Immune Profile of Ciliated Muconodular Papillary Tumors

    Emiko Udo, Sayuri Nakamura, Mikiko Hashisako, Junya Fukuoka

    MODERN PATHOLOGY   2017年2月

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    記述言語:英語  

  • The Proposal of User-Friendly Formula to Separate CTD-IPs and IIPs

    Mutsumi Dairiki, Mikiko Hashisako, Shuntaro Sato, Kensuke Kataoka, Yasuhiro Kondoh, Hiroyuki Taniguchi, Hiromi Ichikawa, Junya Fukuoka

    MODERN PATHOLOGY   2017年2月

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    記述言語:英語  

  • The Proposal of User-Friendly Formula to Separate CTD-IPs and IIPs

    Mutsumi Dairiki, Mikiko Hashisako, Shuntaro Sato, Kensuke Kataoka, Yasuhiro Kondoh, Hiroyuki Taniguchi, Hiromi Ichikawa, Junya Fukuoka

    LABORATORY INVESTIGATION   2017年2月

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    記述言語:英語  

  • Immune Profile of Ciliated Muconodular Papillary Tumors

    Emiko Udo, Sayuri Nakamura, Mikiko Hashisako, Junya Fukuoka

    LABORATORY INVESTIGATION   2017年2月

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    記述言語:英語  

  • 扁平上皮化生 通常型間質性肺炎における急性増悪の組織学的特徴と予後不良因子(Squamous metaplasia: Factor of acute exacerbation and poor prognosis in usual interstitial pneumonia)

    原 正武, 橋迫 美貴子, 山野 泰彦, 田中 伴典, 田畑 和宏, 上甲 剛, 近藤 康博, 谷口 博之, 福岡 順也

    日本病理学会会誌   2016年4月

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    記述言語:英語  

    扁平上皮化生 通常型間質性肺炎における急性増悪の組織学的特徴と予後不良因子(Squamous metaplasia: Factor of acute exacerbation and poor prognosis in usual interstitial pneumonia)

  • 急性線維素性器質化肺炎とランゲルハンス細胞組織球増殖症が併発した1症例(A case of combined acute fibrinous and organizing pneumonia and Langerhans cell histiocytosis)

    石田 佳央理, 田中 伴典, 橋迫 美貴子, Groen Ruben, 角川 智之, 原 敦子, 坂本 憲穂, 福岡 順也

    日本病理学会会誌   2016年4月

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    記述言語:英語  

    急性線維素性器質化肺炎とランゲルハンス細胞組織球増殖症が併発した1症例(A case of combined acute fibrinous and organizing pneumonia and Langerhans cell histiocytosis)

  • Pathology of idiopathic interstitial pneumonias

    Mikiko Hashisako, Junya Fukuoka

    Clinical medicine insights. Circulatory, respiratory and pulmonary medicine   2016年2月

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    記述言語:英語  

    The updated classification of idiopathic interstitial pneumonias (IIPs) in 2013 by American Thoracic Society/European Respiratory Society included several important revisions to the categories described in the 2002 classification. In the updated classification, lymphoid interstitial pneumonia (LIP) was moved from major to rare IIPs, pleuroparenchymal fibroelastosis (PPFE) was newly included in the rare IIPs, acute fibrinous and organizing pneumonia (AFOP) and interstitial pneumonias with a bronchiolocentric distribution are recognized as rare histologic patterns, and unclassifiable IIP (UCIP) was classified as an IIP. However, recent reports indicate the areas of concern that may require further evaluation. Here, we describe the histopathologic features of the updated IIPs and their rare histologic patterns and also point out some of the issues to be considered in this context.

    DOI: 10.4137/CCRPM.S23320

  • Squamous Metaplasia: Indicator of Acute Exacerbation and Poor Prognostic Factor in Usual Interstitial Pneumonia

    Masatake Hara, Mikiko Hashisako, Yasuhiko Yamano, Takeshi Johkoh, Yasuhiro Kondoh, Hiroyuki Taniguchi, Junya Fukuoka

    LABORATORY INVESTIGATION   2016年2月

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    記述言語:英語  

  • Squamous Metaplasia: Indicator of Acute Exacerbation and Poor Prognostic Factor in Usual Interstitial Pneumonia

    Masatake Hara, Mikiko Hashisako, Yasuhiko Yamano, Takeshi Johkoh, Yasuhiro Kondoh, Hiroyuki Taniguchi, Junya Fukuoka

    MODERN PATHOLOGY   2016年2月

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    記述言語:英語  

  • Fluorescence Navigation of Gastric Tumors by 5-ALA Mediated Photodynamic Diagnosis With a LASER-Equipped Video Endoscope

    Kumi Ogihara, Hajime Isomoto, Takemasa Senoo, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Hitomi Minami, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao

    GASTROINTESTINAL ENDOSCOPY   2015年5月

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    記述言語:英語  

  • 3D Pathology Construction Reveals Framework Structure of the Lung and Increase of Pores of Kohn as an Initial Event of Emphysema

    Akira Yoshikawa, Tomonori Tanaka, Mikiko Hashisako, Yukio Kashima, Hiroki Karata, Kazuhiro Tabata, Junya Fukuoka

    MODERN PATHOLOGY   2015年2月

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    記述言語:英語  

  • 3D Pathology Construction Reveals Framework Structure of the Lung and Increase of Pores of Kohn as an Initial Event of Emphysema

    Akira Yoshikawa, Tomonori Tanaka, Mikiko Hashisako, Yukio Kashima, Hiroki Karata, Kazuhiro Tabata, Junya Fukuoka

    LABORATORY INVESTIGATION   2015年2月

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    記述言語:英語  

  • 肺癌背景肺におけるMuc5B発現

    高畑 海音子, 橋迫 美貴子, 田中 伴典, 田畑 和宏, 加島 志郎, 山崎 直哉, 土谷 智史, 松本 桂太郎, 宮崎 拓郎, 永安 武, 福岡 順也

    肺癌   2014年10月

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    記述言語:日本語  

    肺癌背景肺におけるMuc5B発現

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所属学協会

  • The International Academy of Pathology

  • Pulmonary Pathology Society

  • 日本肺癌学会

  • 日本呼吸器学会

  • 日本癌学会

  • 日本臨床細胞学会

  • 日本病理学会

  • 日本病理学会

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  • 日本呼吸器学会

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  • The International Academy of Pathology

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  • Pulmonary Pathology Society

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  • 日本癌学会

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  • 日本臨床細胞学会

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  • 日本肺癌学会

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委員歴

  • 日本病理学会   評議員   国内

    2023年4月 - 2024年3月   

  • 日本病理学会   学術評議員   国内

    2023年4月 - 2024年3月   

共同研究・競争的資金等の研究課題

  • M2マクロファージ阻害による特発性肺線維症合併肺癌の術後急性増悪・癌悪性度の克服

    研究課題/領域番号:24K12016  2024年4月 - 2027年3月

    科学研究費助成事業  基盤研究(C)

    河野 幹寛, 竹中 朋祐, 坪内 和哉, 橋迫 美貴子, 吉住 朋晴

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    資金種別:科研費

    特発性肺線維症(IPF)は原因不明・予後不良の間質性肺炎で、高率に肺癌を合併する。IPF合併肺癌は予後不良であり、外科切除を行えたとしても術後のIPF急性増悪の発症リスクが高い。本研究の目的は、肺線維化進行・癌悪性度獲得の両者に関与していると言われているM2マクロファージのIPF合併肺癌の肺切除後IPF急性増悪ならびに発癌・癌悪性度獲得における意義を明らかにし、M2マクロファージ阻害による肺切除後IPF急性増悪の予防・治療法ならびにIPF合併肺癌の新規治療の開発を目指す。本研究により、術後IPF急性増悪の抑制・IPF合併肺癌の予後改善に向けた新たな治療戦略の確立が期待される。

    CiNii Research

  • 空間的マルチオミクス解析による軟部肉腫の腫瘍微小環境の解明と代謝標的治療法の探索

    研究課題/領域番号:23K27385  2023年4月 - 2027年3月

    科学研究費助成事業  基盤研究(B)

    小田 義直, 孝橋 賢一, 岩崎 健, 谷口 緑, 山本 猛雄, 橋迫 美貴子

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    資金種別:科研費

    骨軟部腫瘍の多くは、分化傾向に基づく診断分類が行われるが、病理診断困難例が多く予後不良である。申請者はこれまでに骨軟部肉腫における分子治療薬の標的となる癌シグナル経路の異常亢進と、これに誘導される複数の免疫チェックポイント分子の異常発現を明らかにした。しかし、軟部肉腫の腫瘍微小環境における物質代謝状態は未解明である。
    本研究では網羅的代謝物解析と複数の細胞特異的マーカーを高分解能で同時計測可能な次世代蛋白定量解析法を組み合わせ、空間的不均一性を1細胞レベルで網羅的に評価可能な「プロテオーム・メタボローム比較解析」を行い、新規診断バイオマーカーや新規治療標的となる代謝プロファイルを解明する。

    CiNii Research

担当授業科目

  • 臨床実習I

    2024年4月 - 2025年3月   通年

  • 病理学(総論)

    2023年4月 - 2023年9月   前期

  • 臨床腫瘍学の基本

    2021年10月 - 2022年3月   後期

  • 臨床実習I

    2021年4月 - 2022年3月   通年

  • 病因と病態Ⅰ

    2021年4月 - 2021年9月   前期

  • 3年次研究室配属(医学科・生命科学科)

    2021年4月 - 2021年9月   前期

  • 臨床腫瘍学の基本

    2020年10月 - 2021年3月   後期

  • 臨床実習I

    2020年4月 - 2021年3月   通年

  • 3年次研究室配属(医学科・生命科学科)

    2020年4月 - 2020年9月   前期

  • 病因と病態Ⅰ

    2020年4月 - 2020年9月   前期

  • 臨床実習

    2019年4月 - 2020年3月   通年

  • 病理学総論

    2019年4月 - 2019年9月   前期

▼全件表示

専門診療領域

  • 生物系/医歯薬学/基礎医学/人体病理学

医師免許取得年

  • 2008年