Peroxisome Deficiency Impairs BDNF Signaling and Memory Reviewed International journal

Yuichi Abe, Yoshiki Nishimura, Kaori Nakamura, Shigehiko Tamura, Masanori Honsho, Hiroshi Udo, Toshihide Yamashita and Yukio Fujiki

Front. Cell Dev. Biol.   8   1 - 15   2020.10

Recent insights into peroxisome biogenesis and associated diseases Reviewed International journal

Yukio Fujiki, Yuichi Abe, Yuuta Imoto, Akemi J. Tanaka, Kanji Okumoto, Masanori Honsho, Shigehiko Tamura, Non Miyata, Toshihide Yamashita, Wendy K. Chung, Tsuneyoshi Kuroiwa

Journal of Cell Science   133 ( 9 )   2020.5

A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder Reviewed

Akemi J. Tanaka, Kanji Okumoto, Shigehiko Tamura, Yuichi Abe, Yoel Hirsch, Liyong Deng, Joseph Ekstein, Wendy K. Chung, Yukio Fujiki

Cold Spring Harbor Molecular Case Studies   5 ( 1 )   2019.2

Blue native PAGE: Applications to study peroxisome biogenesis Reviewed

Kanji Okumoto, Shigehiko Tamura, Yukio Fujiki

Methods in Molecular Biology   1595   197 - 205   2017.4

AAA Peroxins and Their Recruiter Pex26p Modulate the Interactions of Peroxins Involved in Peroxisomal Protein Import Reviewed

Shigehiko Tamura, Naomi Matsumoto, Ryota Takeba, Yukio Fujiki

JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 35 )   24336 - 24346   2014.8

Molecular basis for peroxisome biogenesis disorders Reviewed International journal

Y. Fujiki, K. Okumoto, S. Mukai, S. Tamura

Molecular Machines Involved in Peroxisome Biogenesis and Maintenance   91 - 110   2014.2

Molecular basis for peroxisome biogenesis disorders Reviewed International journal

Y. Fujiki, K. Okumoto, S. Mukai, S. Tamura

Molecular Machines Involved in Peroxisome Biogenesis and Maintenance   91 - 110   2014.2

Peroxisome biogenesis in mammalian cells Reviewed

Yukio Fujiki, Kanji Okumoto, Satoru Mukai, Masanori Honsho, Shigehiko Tamura

Frontiers in Physiology   5 AUG   2014.1

ペルオキシソームの形成・制御とその障害 Reviewed

生体の科学   2012.10

New insights into dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p in shuttling of PTS1-receptor Pex5p during peroxisome biogenesis. Reviewed

Fujiki Y, Nashiro C, Miyata N, Tamura S, Okumoto K

Biochimica et biophysica acta   1823 ( 1 )   145 - 149   2012.1

Recruiting Mechanism of the AAA Peroxins, Pex1p and Pex6p, to Pex26p on the Peroxisomal Membrane Reviewed

Chika Nashiro, Astuko Kashiwagi, Takashi Matsuzaki, Shigehiko Tamura, Yukio Fujiki

TRAFFIC   12 ( 6 )   774 - 788   2011.6

Monomer-dimer transition of the conserved N-terminal domain of the mammalian peroxisomal matrix protein import receptor, Pex14p Reviewed

Jian-Rong Su, Kazuki Takeda, Shigehiko Tamura, Yukio Fujiki, Kunio Miki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   394 ( 1 )   217 - 221   2010.3

Crystal structure of the conserved N-terminal domain of the peroxisomal matrix protein import receptor, Pex14p Reviewed

Jian-Rong Su, Kazuki Takeda, Shigehiko Tamura, Yukio Fujiki, Kunio Miki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   106 ( 2 )   417 - 421   2009.1

Dynamic and functional assembly of the AAA peroxins,, Pex1p and Pex6p, and their membrane receptor Pex26p involved in shuttling of the PTS1 receptor Pex5p in peroxisome biogenesis Reviewed

Yukio Fujiki, Non Miyata, Naomi Matsumoto, Shigehiko Tamura

BIOCHEMICAL SOCIETY TRANSACTIONS   36 ( Pt 1 )   109 - 113   2008.2

A pathogenic gene in an inherited peroxisome disorder and its cellular dysfunction Reviewed

Shigehiko Tamura

Seikagaku   79 ( 4 )   329 - 339   2007.12

Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p Reviewed

Shigehiko Tamura, Shinobu Yasutake, Naomi Matsumoto, Yukio Fujiki

JOURNAL OF BIOLOGICAL CHEMISTRY   281 ( 38 )   27693 - 27704   2006.9

Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex. Reviewed

Furuki S, Tamura S, Matsumoto N, Miyata N, Moser A, Moser HW, Fujiki Y

The Journal of biological chemistry   281 ( 3 )   1317 - 1323   2006.1

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation Reviewed International journal

N Matsumoto, S Tamura, S Furuki, N Miyata, A Moser, N Shimozawa, HW Moser, Y Suzuki, N Kondo, Y Fujiki

AMERICAN JOURNAL OF HUMAN GENETICS   73 ( 2 )   233 - 246   2003.8

The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes Reviewed

N Matsumoto, S Tamura, Y Fujiki

NATURE CELL BIOLOGY   5 ( 5 )   454 - 460   2003.5

Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction Reviewed

S Tamura, N Matsumoto, A Imamura, N Shimozawa, Y Suzuki, N Kondo, Y Fujiki

BIOCHEMICAL JOURNAL   357 ( 2 )   417 - 426   2001.7

The peroxin Pex6p gene is impaired in peroxisomal biogenesis disorders of complementation group 6 Reviewed

N Matsumoto, S Tamura, A Moser, HW Moser, N Braverman, Y Suzuki, N Shimozawa, N Kondo, Y Fujiki

JOURNAL OF HUMAN GENETICS   46 ( 5 )   273 - 277   2001.4

Pex3p is required for a membrane-assembly stage in peroxisome biogenesis Reviewed

K Ghaedi, S Tamura, K Okumoto, Y Matsuzono, Y Fujiki

MOLECULAR BIOLOGY OF THE CELL   11   423A - 423A   2000.12

The peroxin Pex3p initiates membrane assembly in peroxisome biogenesis Reviewed

K Ghaedi, S Tamura, K Okumoto, Y Matsuzono, Y Fujiki

MOLECULAR BIOLOGY OF THE CELL   11 ( 6 )   2085 - 2102   2000.6

Peroxisome biogenesis and molecular defects in peroxisome assembly disorders. Reviewed International journal

Fujiki Y., Okumoto K., Otera H., Tamura S.

Cell Biochem. Biophys.   32   155 - 164   2000.1

Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants Reviewed International journal

R Toyama, S Mukai, A Itagaki, S Tamura, N Shimozawa, Y Suzuki, N Kondo, RJA Wanders, Y Fujiki

HUMAN MOLECULAR GENETICS   8 ( 9 )   1673 - 1681   1999.9

Isolation and characterization of novel peroxisome biogenesis-defective Chinese hamster ovary cell mutants using green fluorescent protein Reviewed

K Ghaedi, A Kawai, K Okumoto, S Tamura, N Shimozawa, Y Suzuki, N Kondo, Y Fujiki

EXPERIMENTAL CELL RESEARCH   248 ( 2 )   489 - 497   1999.5

Newly identified Chinese hamster ovary cell mutants defective in peroxisome assembly represent complementation group A of human peroxisome biogenesis disorders and one novel group in mammals Reviewed International journal

K Ghaedi, A Itagaki, R Toyama, S Tamura, T Matsumura, A Kawai, N Shimozawa, Y Suzuki, N Kondo, Y Fujiki

EXPERIMENTAL CELL RESEARCH   248 ( 2 )   482 - 488   1999.5

The peroxin Pex14p - cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis Reviewed

N Shimizu, R Itoh, Y Hirono, H Otera, K Ghaedi, K Tateishi, S Tamura, K Okumoto, T Harano, S Mukai, Y Fujiki

JOURNAL OF BIOLOGICAL CHEMISTRY   274 ( 18 )   12593 - 12604   1999.4

Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly Reviewed

Y Matsuzono, N Kinoshita, S Tamura, N Shimozawa, M Hamasaki, K Ghaed, RJA Wanders, Y Suzuki, N Kondo, Y Fujiki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   96 ( 5 )   2116 - 2121   1999.3

Newly identified Chinese hamster ovary cell mutants defective in peroxisome assembly represent complementation group A of human peroxisome biogenesis disorders and one novel group in mammals. International journal

Ghaedi, K., Itagaki, A., Toyama, R., Tamura, S., Matsumura, T., Kawai, A., Shimozawa, N., Suzuki, Y., Kondo, N., and Fujiki, Y.

Exp. Cell Res.   248 ( 2 )   482 - 488   1999.1

Isolation, characterization, and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants. Reviewed International journal

Toyama, R., Mukai, S., Itagaki, A., Tamura, S., Shimozawa, N., Suzuki, Y., Kondo, N., Wanders, R. J. A., and Fujiki, Y.

Hum. Mol. Genet.   8 ( 9 )   1673 - 1681   1999.1

Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D Reviewed

M Honsho, S Tamura, N Shimozawa, Y Suzuki, N Kondo, Y Fujiki

AMERICAN JOURNAL OF HUMAN GENETICS   63 ( 6 )   1622 - 1630   1998.12

Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders Reviewed

A Imamura, S Tamura, N Shimozawa, Y Suzuki, ZY Zhang, T Tsukamoto, T Orii, N Kondo, T Osumi, Y Fujiki

HUMAN MOLECULAR GENETICS   7 ( 13 )   2089 - 2094   1998.12

Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B Reviewed

K Okumoto, R Itoh, N Shimozawa, Y Suzuki, S Tamura, N Kondo, Y Fujiki

HUMAN MOLECULAR GENETICS   7 ( 9 )   1399 - 1405   1998.9

Clofibrate-inducible, 2X-kDa peroxisomal integral membrane protein is encoded by PEX11 Reviewed

Abe, I, K Okumoto, S Tamura, Y Fujiki

FEBS LETTERS   431 ( 3 )   468 - 472   1998.7

PEX12, the pathogenic gene of group III Zellweger syndrome: cDNA cloning by functional complementation on a CHO cell mutant, patient analysis, and characterization of Pex12p Reviewed

K Okumoto, N Shimozawa, A Kawai, S Tamura, T Tsukamoto, T Osumi, H Moser, RJA Wanders, Y Suzuki, N Kondo, Y Fujiki

MOLECULAR AND CELLULAR BIOLOGY   18 ( 7 )   4324 - 4336   1998.7

A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p Reviewed

S Tamura, N Shimozawa, Y Suzuki, T Tsukamoto, T Osumi, Y Fujiki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   245 ( 3 )   883 - 886   1998.4

Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I Reviewed

S Tamura, K Okumoto, R Toyama, N Shimozawa, T Tsukamoto, Y Suzuki, T Osumi, N Kondo, Y Fujiki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   95 ( 8 )   4350 - 4355   1998.4

SHORT EXTERNAL LOOPS AS POTENTIAL SUBSTRATE-BINDING SITE OF GAMMA-AMINOBUTYRIC-ACID TRANSPORTERS Reviewed

S TAMURA, H NELSON, A TAMURA, N NELSON

JOURNAL OF BIOLOGICAL CHEMISTRY   270 ( 48 )   28712 - 28715   1995.12

STRUCTURE, FUNCTION AND BRAIN LOCALIZATION OF NEUROTRANSMITTER TRANSPORTERS Reviewed

F JURSKY, S TAMURA, A TAMURA, S MANDIYAN, H NELSON, N NELSON

JOURNAL OF EXPERIMENTAL BIOLOGY   196   283 - 295   1994.11

GASTRIC DNA-BINDING PROTEINS RECOGNIZE UPSTREAM SEQUENCE MOTIFS OF PARIETAL CELL-SPECIFIC GENES Reviewed

S TAMURA, XH WANG, M MAEDA, M FUTAI

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   90 ( 22 )   10876 - 10880   1993.11

SEQUENCE MOTIF IN CONTROL REGIONS OF THE H+/K+ ATPASE ALPHA-SUBUNIT AND BETA-SUBUNIT GENES RECOGNIZED BY GASTRIC SPECIFIC NUCLEAR PROTEIN(S) Reviewed

S TAMURA, KI OSHIMAN, T NISHI, M MORI, M MAEDA, M FUTAI

FEBS LETTERS   298 ( 2-3 )   137 - 141   1992.2

THE RAT H+ K+-ATPASE BETA-SUBUNIT GENE AND RECOGNITION OF ITS CONTROL REGION BY GASTRIC DNA-BINDING PROTEIN Reviewed

M MAEDA, KI OSHIMAN, S TAMURA, S KAYA, S MAHMOOD, MA REUBEN, LS LASATER, G SACHS, M FUTAI

JOURNAL OF BIOLOGICAL CHEMISTRY   266 ( 32 )   21584 - 21588   1991.11

CONTROL REGION AND GASTRIC SPECIFIC TRANSCRIPTION OF THE RAT H+,K+-ATPASE ALPHA-SUBUNIT GENE Reviewed

KI OSHIMAN, K MOTOJIMA, S MAHMOOD, A SHIMADA, S TAMURA, M MAEDA, M FUTAI

FEBS LETTERS   281 ( 1-2 )   250 - 254   1991.4

HUMAN GASTRIC (H+ + K+)-ATPASE GENE - SIMILARITY TO (NA+ + K+)-ATPASE GENES IN EXON INTRON ORGANIZATION BUT DIFFERENCE IN CONTROL REGION Reviewed

M MAEDA, KI OSHIMAN, S TAMURA, M FUTAI

JOURNAL OF BIOLOGICAL CHEMISTRY   265 ( 16 )   9027 - 9032   1990.6

STRUCTURE AND CHEMICAL MODIFICATION OF PIG GASTRIC (H++K+)-ATPASE Reviewed

M MAEDA, S TAMURA, M FUTAI

BIOENERGETICS   217 - 225   1990.5

PIG GASTRIC (H+ + K+)-ATPASE - LYS-497 CONSERVED IN CATION TRANSPORTING ATPASES IS MODIFIED WITH PYRIDOXAL 5'-PHOSPHATE Reviewed

S TAMURA, M TAGAYA, M MAEDA, M FUTAI

JOURNAL OF BIOLOGICAL CHEMISTRY   264 ( 15 )   8580 - 8584   1989.5

THE FACTOR-V-ACTIVATING ENZYME (RVV-V) FROM RUSSELLS VIPER VENOM - IDENTIFICATION OF ISOPROTEINS RVV-V-ALPHA, RVV-V-BETA, AND RVV-V-GAMMA AND THEIR COMPLETE AMINO-ACID SEQUENCES Reviewed

F TOKUNAGA, K NAGASAWA, S TAMURA, T MIYATA, S IWANAGA, W KISIEL

JOURNAL OF BIOLOGICAL CHEMISTRY   263 ( 33 )   17471 - 17481   1988.11

ペルオキシソーム膜透過輸送装置因子Pex14の膜配向性はPex6が調節する

#安光赳彦、@藤木幸夫、@田村茂彦

令和６年度日本生化学会九州支部例会  2024.6 

ペルオキシソーム形成因子Pex14の膜配向性変化が担う膜透過輸送メカニズム解析

#安光赳彦、@田村茂彦、@藤木幸夫

第９６回日本生化学会  2023.11 

Phosphorylation of Pex14p regulates peroxisomal protein import. International conference

#Takehiko Yasumitsu, #Koichiro Yamashita, @Shigehiko Tamura, @Masanori Honsho, @Kanji Okumoto, @Hiroto Yada, @Yuichi Yagita, @Hidetaka Kosako, @Yukio Fujiki

OEPM 2020  2020.10 

ペルオキシソーム輸送制御におけるPex14pの細胞分裂期特異的なリン酸化とペルオキシン間相互作用の解析

#安光赳彦、#山下昂一郎、@田村茂彦、@本庄雅則、@小迫英尊、@藤木幸夫

令和２年度日本生化学会九州支部例会  2020.5 

ペルオキシソーム局在性テイルアンカー型タンパク質ACBD5の翻訳アレストを介した局在化効率獲得機構

#小山桂恵奈, @奥本寛治, @田村茂彦, @藤木幸夫

第4２回日本分子生物学会  2019.12 

ペルオキシソーム局在性テイルアンカー型膜タンパク質の輸送局在化機構

@奥本寛治, @田村 茂彦, @八木田悠一、@本庄雅則、@藤木幸夫

第4１回日本分子生物学会  2018.11 

ペルオキシソーム形成因子Pex14pの細胞周期依存的なリン酸化による機能制御

#山下昂一郎, @田村茂彦, @藤木幸夫

平成３０年度 日本生化学会 九州支部例会  2018.6 

テイルアンカー型タンパク質ACBD5の翻訳速度とペルオキシソームへの輸送・局在化効率の関連性の検討

#小山桂恵奈, @奥本寛治, @田村茂彦, @藤木幸夫

平成３０年度 日本生化学会 九州支部例会  2018.6 

ペルオキシソーム膜透過装置複合体の同定と輸送メカニズムの解明

@田村 茂彦, #河村優子, @藤木幸夫

第９0回日本生化学会  2017.12 

ペルオキシソーム膜透過輸送にはPex14p複合体の動的な構造変化が必要である

#河村優子, @田村 茂彦, @藤木幸夫

「新生鎖の生物学」班会議（別府）  2017.11 

ペルオキソソームの恒常性：膜およびマトリックスタンパク質輸送の分子基盤

@藤木幸夫, @奥本寛治, @八木田悠一, @田村 茂彦

第１７回日本蛋白質科学会年会  2017.6 

Peroxisomal matrix protein transport requires a series of constitutional changes of Pex14p homo-oligomers International conference

@Yukio Fujiki, #Yuko Kawamura, and @Shigehiko Tamura

EMBO conference "Protein translocation and cellular homeostasis"  2017.3 

Core components of peroxisomal membrane translocator of matrix proteins. EMBO conference International conference

@Yukio Fujiki, #Yuko Kawamura, and @Shigehiko Tamura

EMBO conference "Protein translocation and cellular homeostasis"  2017.3 

ペルオキシソーム形成の分子基盤: 膜生合成およびマトリックスタンパク質輸送の分子機構

#Yuqiong Liu, @田村茂彦, @奥本寛治, @八木田 悠一, #河村優子, #永田愛子, @藤木幸夫

第３９回日本分子生物学会  2016.12 

ペルオキシソーム膜透過輸送にはPex14p複合体の動的な構成変化が必要である

#河村優子, @田村 茂彦, @藤木幸夫

第３９回日本分子生物学会  2016.12 

Identification of core components of peroxisomal membrane translocator.

2016.9 

Mechanistic insight into peroxisomal protein import International conference

@Shigehiko Tamura, @Kanji Okumoto, @Naomi Matsumoto, #Yuri Shirahama, #Ryota Takeba, @Yukio Fujiki

EMBO Conference: Mechanisms and regulation of protein translocation  2015.3 

ペルオキシソーム膜透過装置複合体の同定とマトリックスタンパク質輸送の分子メカニズム解明

@田村 茂彦, #小川智大, @藤木 幸夫

第８7回日本生化学会  2014.10 

ペルオキシソームタンパク質膜透過装置複合体の同定と膜透過メカニズム

@田村 茂彦, #矢田裕人, @藤木 幸夫

第８６回日本生化学会  2013.9 

AAAペルオキシンとPex26pによって制御されるペルオキシン間相互作用

@田村 茂彦

第８５回日本生化学会  2012.12 

AAA peroxins and their recruiter Pex26p modulate the peroxin interactions involved in peroxisomal protein import International conference

2011.11 

ナンセンス変異の抑制によるペルオキシソーム障害の回復メカニズム

田村茂彦、中村博美、藤木幸夫

日本生化学会  2011.9 

BN-PAGEによるペルオキシン複合体の解析 Invited

田村茂彦、藤木幸夫

日本蛋白質科学学会  2011.6 

ペルオキシソーム形成とその障害の分子メカニズム Invited

@田村茂彦

先端医療薬学研究センター講演会  2012.3 

AAAペルオキシンとPex26pによって制御されるペルオキシン相互作用

田村茂彦、竹場亮太、藤木幸夫

日本生化学会・分子生物学会  2010.12 

Restoration of peroxisome biogenesis in perosxisome-deficient cells with a nonsense suppressor compound (G418). International conference

The 3rd International Symposium on Protein Community  2010.10 

ペルオキシソーム恒常性の維持と破綻のメカニズム解明： 本研究はペルオキシソームをモデルオルガネラとし、膜を介したタンパク質輸送と機能制御システム、さらにはそれらの機能障害がもたらすペルオキシソーム欠損症の発症メカニズム解明からペルオキシソーム恒常性維持システムの全容解明を目指している。この中でも特に、ペルオキシソーム代謝産物のひとつであり、認知症改善効果や学習能の亢進などに潜在活性を有するプラスマローゲンに着目し、プラスマローゲン精製とその臨床的応用において世界をリードする研究を行なっているレオロジー機能食品研究所との共同研究を進めることで、ペルオキシソーム恒常性維持を標的とした抗老化、さらには脳機能維持のための戦略創出へと研究を展開させる。2020年度は、2019年度の共同研究によって得られた研究成果（Abe, Y. et al, J. Biol. Chem. (2020)； Yamashita, K. et al, J. Cell Biol. (2020) in press）等をさらに発展させるべく共同研究を推進する。

2020.4 - 2021.3

共同研究

ペルオキシソーム恒常性の維持と破綻のメカニズム解明： 本研究はペルオキシソームをモデルオルガネラとし、膜を介したタンパク質輸送と機能制御システム、さらにはそれらの機能障害がもたらすペルオキシソーム欠損症の発症メカニズム解明からペルオキシソーム恒常性維持システムの全容解明を目指している。この中でも特に、ペルオキシソーム代謝産物のひとつであり、認知症改善効果や学習能の亢進などに潜在活性を有するプラスマローゲンに着目し、プラスマローゲン精製とその臨床的応用において世界をリードする研究を行なっているレオロジー機能食品研究所との共同研究を進めることで、ペルオキシソーム恒常性維持を標的とした抗老化、さらには脳機能維持のための戦略創出へと研究を展開させる。

2019.4 - 2020.3

共同研究

ペルオキシソーム恒常性の維持とその制御メカニズム

Grant number：19K06567  2019 - 2021

日本学術振興会  科学研究費助成事業  基盤研究(C)

ペルオキシソームの形成とその障害の分子基盤の解明

Grant number：17H03675  2017 - 2019

日本学術振興会  科学研究費助成事業  基盤研究(B)

ペルオキシソーム膜透過輸送の分子機序とその制御システム解明

Grant number：16K07275  2016 - 2018

日本学術振興会  科学研究費助成事業  基盤研究(C)

新生鎖テイルアンカー型タンパク質(TA)の輸送・膜挿入と品質管理

Grant number：26116007  2014 - 2018

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

生体機能の恒常性維持機構に関する研究

2014 - 2015

ペルオキシソーム形成障害の発症機構の解明

2012 - 2016

日本学術振興会  科学研究費助成事業  基盤研究(A)

ペルオキシソーム膜透過装置複合体とその制御メカニズムの解明

Grant number：24570134  2012 - 2014

日本学術振興会  科学研究費助成事業  基盤研究(C)

ペルオキシソーム機能制御におけるAAAペルオキシンの役割

Grant number：21570116  2009 - 2011

日本学術振興会  科学研究費助成事業  基盤研究(C)

Integrative Biology, Advanced CourseⅡ

2024.4 - 2024.9   First semester

統合生物科学特論Ⅱ

2024.4 - 2024.9   First semester

レトリック基礎

2024.4 - 2024.9   First semester

レトリック基礎

2024.4 - 2024.9   First semester

プレゼンテーション基礎

2024.4 - 2024.9   First semester

プレゼンテーション基礎

2024.4 - 2024.9   First semester

生命の科学 A

2023.12 - 2024.2   Winter quarter

課題協学科目

2023.10 - 2024.3   Second semester

生物科学Ⅱ

2023.10 - 2023.12   Fall quarter

Basic BiologyⅡ

2023.10 - 2023.12   Fall quarter

生物学特別講義Ⅰ

2023.6 - 2023.8   Summer quarter

基幹教育セミナー

2023.6 - 2023.8   Summer quarter

Special Lecture of BiologyⅡ

2023.6 - 2023.8   Summer quarter

生物科学特別講義Ⅱ

2023.6 - 2023.8   Summer quarter

生化学

2023.4 - 2023.9   First semester

レトリック基礎

2023.4 - 2023.9   First semester

レトリック基礎

2023.4 - 2023.9   First semester

プレゼンテーション基礎

2023.4 - 2023.9   First semester

プレゼンテーション基礎

2023.4 - 2023.9   First semester

生命の科学 A

2022.12 - 2023.2   Winter quarter

課題協学科目

2022.10 - 2023.3   Second semester

生物科学Ⅱ

2022.10 - 2022.12   Fall quarter

Basic BiologyⅡ

2022.10 - 2022.12   Fall quarter

生物科学特論Ⅳ

2022.10 - 2022.12   Fall quarter

基幹教育セミナー

2022.6 - 2022.8   Summer quarter

Integrative Biology, Advanced CourseⅡ

2022.4 - 2022.9   First semester

統合生物科学特論Ⅱ

2022.4 - 2022.9   First semester

レトリック基礎

2022.4 - 2022.9   First semester

レトリック基礎

2022.4 - 2022.9   First semester

プレゼンテーション基礎

2022.4 - 2022.9   First semester

プレゼンテーション基礎

2022.4 - 2022.9   First semester

生化学

2022.4 - 2022.9   First semester

生命の科学 A

2021.12 - 2022.2   Winter quarter

課題協学科目

2021.10 - 2022.3   Second semester

生物科学 II

2021.10 - 2021.12   Fall quarter

基幹教育セミナー

2021.6 - 2021.8   Summer quarter

レトリック基礎

2021.6 - 2021.8   Summer quarter

レトリック基礎

2021.6 - 2021.8   Summer quarter

プレゼンテーション基礎

2021.6 - 2021.8   Summer quarter

プレゼンテーション基礎

2021.6 - 2021.8   Summer quarter

生化学

2021.4 - 2021.9   First semester

生命の科学 A

2020.12 - 2021.2   Winter quarter

統合生命科学特別講義 II

2020.12 - 2021.2   Winter quarter

分子生命科学特論IV

2020.10 - 2020.12   Fall quarter

分子生命科学基礎II

2020.10 - 2020.12   Fall quarter

基幹教育セミナー

2020.6 - 2020.8   Summer quarter

レトリック基礎

2020.6 - 2020.8   Summer quarter

レトリック基礎

2020.6 - 2020.8   Summer quarter

プレゼンテーション基礎

2020.6 - 2020.8   Summer quarter

プレゼンテーション基礎

2020.6 - 2020.8   Summer quarter

生化学

2020.4 - 2020.9   First semester

体験してわかる自然科学

2019.12 - 2020.2   Winter quarter

生命の科学 A

2019.12 - 2020.2   Winter quarter

課題協学

2019.10 - 2020.3   Second semester

分子生命科学基礎II

2019.10 - 2019.12   Fall quarter

基幹教育セミナー

2019.6 - 2019.8   Summer quarter

プレゼンテーション基礎

2019.6 - 2019.8   Summer quarter

プレゼンテーション基礎

2019.6 - 2019.8   Summer quarter

レトリック基礎

2019.6 - 2019.8   Summer quarter

レトリック基礎

2019.6 - 2019.8   Summer quarter

生化学

2019.4 - 2019.9   First semester

体験してわかる自然科学

2018.12 - 2019.2   Winter quarter

生命の科学 A

2018.12 - 2019.2   Winter quarter

課題協学

2018.10 - 2019.3   Second semester

分子生命科学特論IV

2018.10 - 2018.12   Fall quarter

分子生命科学基礎II

2018.10 - 2018.12   Fall quarter

基幹教育セミナー

2018.6 - 2018.8   Summer quarter

プレゼンテーション基礎

2018.6 - 2018.8   Summer quarter

プレゼンテーション基礎

2018.6 - 2018.8   Summer quarter

レトリック基礎

2018.6 - 2018.8   Summer quarter

レトリック基礎

2018.6 - 2018.8   Summer quarter

生化学

2018.4 - 2018.9   First semester

体験してわかる自然科学

2017.12 - 2018.2   Winter quarter

生命の科学 A

2017.12 - 2018.2   Winter quarter

課題協学

2017.10 - 2018.3   Second semester

分子生命科学基礎II

2017.10 - 2017.12   Fall quarter

プレゼンテーション基礎

2017.6 - 2017.8   Summer quarter

プレゼンテーション基礎

2017.6 - 2017.8   Summer quarter

基幹教育セミナー

2017.4 - 2017.9   First semester

生化学

2017.4 - 2017.9   First semester

課題協学 B

2016.10 - 2017.3   Second semester

生命の科学 A

2016.10 - 2017.3   Second semester

基幹教育セミナー

2016.4 - 2016.9   First semester

生化学

2016.4 - 2016.9   First semester

課題協学 B

2016.4 - 2016.9   First semester

基幹教育セミナー

2016.4 - 2016.9   First semester

課題協学 A

2015.10 - 2016.3   Second semester

生命の科学 A

2015.10 - 2016.3   Second semester

基幹教育セミナー

2015.4 - 2015.9   First semester

生化学

2015.4 - 2015.9   First semester

課題協学 A

2015.4 - 2015.9   First semester

基幹教育セミナー

2015.4 - 2015.9   First semester

課題協学 A

2014.10 - 2015.3   Second semester

基幹教育セミナー

2014.4 - 2014.9   First semester

生化学II

2014.4 - 2014.9   First semester

理系コア生物科学II

2014.4 - 2014.9   First semester

課題協学 A

2014.4 - 2014.9   First semester

基幹教育セミナー

2014.4 - 2014.9   First semester

理系コア生物科学II

2013.10 - 2014.3   Second semester

細胞生物学II

2013.10 - 2014.3   Second semester

分子細胞生物学基礎

2013.10 - 2014.3   Second semester

コアセミナーC

2013.4 - 2013.9   First semester

生化学II

2013.4 - 2013.9   First semester

理系コア生物科学II

2012.10 - 2013.3   Second semester

代謝生理学演習

2012.10 - 2013.3   Second semester

分子細胞生物学基礎

2012.4 - 2012.9   First semester

コアセミナーC

2012.4 - 2012.9   First semester

細胞生物学II

2012.4 - 2012.9   First semester

生化学II

2012.4 - 2012.9   First semester

2023.3   Role：Participation   Title：基幹教育春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2022.9   Role：Speech   Title：課題協学科目第2回FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2022.9   Role：Participation   Title：基幹教育夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2022.5   Role：Speech   Title：課題協学科目第１回FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2022.5   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2022.3   Role：Participation   Title：基幹教育FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2021.9   Role：Participation   Title：基幹教育FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2021.9   Role：Speech   Title：課題協学科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2021.5   Role：Speech   Title：課題協学科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2021.5   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2021.3   Role：Participation   Title：基幹教育FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2020.9   Role：Participation   Title：基幹教育夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2020.9   Role：Participation   Title：課題協学科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2020.6   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2019.4   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2019.4   Role：Participation   Title：課題協学科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2019.3   Role：Participation   Title：基幹教育改革FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2019.3   Role：Participation   Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2018.3   Role：Participation   Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2018.3   Role：Participation   Title：基幹教育改革FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2018.3   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2017.3   Role：Participation   Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2017.3   Role：Participation   Title：基幹教育改革FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2017.3   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2016.3   Role：Participation   Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2016.3   Role：Participation   Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2016.3   Role：Participation   Title：基幹教育改革FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2013.3   Role：Participation   Title：平成24年度理学部FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2012.12   Role：Participation   Title：平成24年度システム生命FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2011.12   Role：Participation   Title：平成23年度システム生命FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2010.10   Role：Participation   Title：平成22年度システム生命FD

Organizer：[Undergraduate school/graduate school/graduate faculty]

2002.12   Role：Participation   Title：平成１４年度第二回全学FD

Organizer：University-wide

2002.7   Role：Participation   Title：平成１４年度第一回全学FD

Organizer：University-wide

2018  Class Teacher 

2017  Class Teacher 

2016  Class Teacher 

2015  Class Teacher 

2014  Class Teacher 

2013  Class Teacher 

2012  Class Teacher 

ペルオキシソームから見た分子細胞生物学

長崎県立長崎北高校  2006.9