記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00422-023-00971-y

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1167/tvst.12.6.27

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掲載種別：研究論文（学術雑誌）   出版者・発行元：{IOP} Publishing  

DOI： 10.1088/1741-2552/abf892

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media {LLC}  

DOI： 10.1007/s00422-020-00848-4

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1101/2020.02.17.953448

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PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1001/jamanetworkopen.2019.18377

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media {LLC}  

DOI： 10.1007/s00422-018-0786-6

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:title>Abstract</jats:title><jats:p>Therapeutic seizures may work for treatment-resistant depression (TRD) by producing neuroplasticity. We evaluated whether magnetic seizure therapy (MST) produces changes in suicidal ideation and neuroplasticity as indexed through transcranial magnetic stimulation and electroencephalography (TMS-EEG) of the dorsolateral prefrontal cortex (DLPFC). Twenty-three patients with TRD were treated with MST. Changes in suicidal ideation was assessed through the Scale for Suicidal Ideation (SSI). Before and after the treatment course, neuroplasticity in excitatory and inhibitory circuits was assessed with TMS-EEG measures of cortical-evoked activity (CEA) and long-interval cortical inhibition (LICI) from the left DLPFC, and the left motor cortex as a control condition. As in our previous report, the relationship between TMS-EEG measures and suicidal ideation was examined with the SSI. Results show that 44.4% of patients experienced resolution of suicidal ideation. Based on DLPFC assessment, MST produced significant CEA increase over the frontal central electrodes (cluster <jats:italic>p</jats:italic> &lt; 0.05), but did not change LICI on a group level. MST also reduced the SSI scores (<jats:italic>p</jats:italic> &lt; 0.005) and the amount of reduction correlated with the decrease in LICI over the right frontal central electrodes (cluster <jats:italic>p</jats:italic> &lt; 0.05; rho = 0.73 for Cz). LICI change identified patients who were resolved of suicidal ideation with 90% sensitivity and 88% specificity (AUC = 0.9, <jats:italic>p</jats:italic> = 0.004). There was no significant finding with motor cortex assessment. Overall, MST produced significant rates of resolution of suicidal ideation. MST also produced neuroplasticity in the frontal cortex, likely through long-term potentiation (LTP)-like mechanisms. The largest reduction in suicidal ideation was demonstrated in patients showing concomitant decreases in cortical inhibition—a mechanism linked to enhanced LTP-like plasticity. These findings provide insights into the mechanisms through which patients experience resolution of suicidal ideation following seizure treatments in depression.</jats:p>

DOI： 10.1038/s41398-018-0302-8

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.specom.2018.03.010

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.nicl.2018.10.015

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Public Library of Science ({PLoS})  

DOI： 10.1371/journal.pone.0182542

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:title>Abstract</jats:title><jats:p>Subsequent to global initiatives in mapping the human brain and investigations of neurobiological markers for brain disorders, the number of multi-site studies involving the collection and sharing of large volumes of brain data, including electroencephalography (EEG), has been increasing. Among the complexities of conducting multi-site studies and increasing the shelf life of biological data beyond the original study are <jats:italic>timely</jats:italic> standardization and documentation of relevant study parameters. We present the insights gained and guidelines established within the EEG working group of the Canadian Biomarker Integration Network in Depression (CAN-BIND). CAN-BIND is a multi-site, multi-investigator, and multi-project network supported by the Ontario Brain Institute with access to Brain-CODE, an informatics platform that hosts a multitude of biological data across a growing list of brain pathologies. We describe our approaches and insights on documenting and standardizing parameters across the study design, data collection, monitoring, analysis, integration, knowledge-translation, and data archiving phases of CAN-BIND projects. We introduce a custom-built EEG toolbox to track data preprocessing with open-access for the scientific community. We also evaluate the impact of variation in equipment setup on the accuracy of acquired data. Collectively, this work is intended to inspire establishing comprehensive and standardized guidelines for multi-site studies.</jats:p>

DOI： 10.1038/s41598-017-07613-x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media {LLC}  

<jats:title>Abstract</jats:title><jats:p>We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients with dystonia and six patients with Parkinson’s disease underwent bilateral deep brain stimulation (DBS) electrode placement. Local field potentials from the DBS electrodes and scalp EEG from the electrodes placed over the motor cortices were recorded while the patients performed externally triggered and self-initiated movements. The coherence calculated between the motor cortex and STN or GPi was found to be coupled to its power in both the beta and the gamma bands. The association of coherence with power suggests that a coupling in neural activity between the basal ganglia and the motor cortex is required for the execution of voluntary movements. Finally, we propose a mathematical model involving coupled neural oscillators which provides a possible explanation for how inter-regional coupling takes place.</jats:p>

DOI： 10.1038/srep34930

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掲載種別：研究論文（学術雑誌）  

DOI： 10.3389/fncir.2016.00078

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1001/jamapsychiatry.2015.3097

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.brs.2015.06.010

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers in Human Neuroscience  

DOI： 10.3389/fnhum.2015.00256

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers Media {SA}  

DOI： 10.3389/fnins.2014.00431

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/j.jneumeth.2014.09.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Popular miRNA target prediction techniques use sequence features to determine the functional miRNA target sites. These techniques commonly ignore the cellular conditions in which miRNAs interact with their targets in vivo. Gene expression data are rich resources that can complement sequence features to take into account the context dependency of miRNAs.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>We introduce BayMiR, a new computational method, that predicts the functionality of potential miRNA target sites using the activity level of the miRNAs inferred from genome-wide mRNA expression profiles. We also found that mRNA expression variation can be used as another predictor of functional miRNA targets. We benchmarked BayMiR, the expression variation, Cometa, and the TargetScan “context scores” on two tasks: predicting independently validated miRNA targets and predicting the decrease in mRNA abundance in miRNA overexpression assays. BayMiR performed better than all other methods in both benchmarks and, surprisingly, the variation index performed better than Cometa and some individual determinants of the TargetScan context scores. Furthermore, BayMiR predicted miRNA target sets are more consistently annotated with GO and KEGG terms than similar sized random subsets of genes with conserved miRNA seed regions. BayMiR gives higher scores to target sites residing near the poly(A) tail which strongly favors mRNA degradation using poly(A) shortening. Our work also suggests that modeling multiplicative interactions among miRNAs is important to predict endogenous mRNA targets.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>We develop a new computational method for predicting the target mRNAs of miRNAs. BayMiR applies a large number of mRNA expression profiles and successfully identifies the mRNA targets and miRNA activities without using miRNA expression data. The BayMiR package is publicly available and can be readily applied to any mRNA expression data sets.</jats:p>
</jats:sec>

DOI： 10.1186/1471-2164-14-592

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Speech Language Hearing Association  

<jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>In this study, the authors sought to quantify the relationships between speech intelligibility (perception) and gaze patterns under different auditory–visual conditions.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Method</jats:title>
<jats:p>Eleven subjects listened to low-context sentences spoken by a single talker while viewing the face of one or more talkers on a computer display. Subjects either maintained their gaze at a specific distance (0°, 2.5°, 5°, 10°, and 15°) from the center of the talker's mouth (CTM) or moved their eyes freely on the computer display. Eye movements were monitored with an eye-tracking system, and speech intelligibility was evaluated by the mean percentage of correctly perceived words.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>With a single talker and a fixed point of gaze, speech intelligibility was similar for all fixations within 10° of the CTM. With visual cues from two talker faces and a speech signal from one of the talkers, speech intelligibility was similar to that of a single talker for fixations within 2.5° of the CTM. With natural viewing of a single talker, gaze strategy changed with speech-signal-to-noise ratio (SNR). For low speech-SNR, a strategy that brought the point of gaze directly to within 2.5° of the CTM was used in approximately 80% of trials, whereas in high speech-SNR it was used in only approximately 50% of trials.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>With natural viewing of a single talker and high speech-SNR, subjects can shift their gaze between points on the talker's face without compromising speech intelligibility. With low-speech SNR, subjects change their gaze patterns to fixate primarily on points that are in close proximity to the talker's mouth. The latter strategy is essential to optimize speech intelligibility in situations where there are simultaneous visual cues from multiple talkers (i.e., when some of the visual cues are distracters).</jats:p>
</jats:sec>

DOI： 10.1044/1092-4388(2012/10-0288)

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0019312

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掲載種別：研究論文（学術雑誌）  

DOI： 10.4103/1463-1741.74002

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media {LLC}  

DOI： 10.1155/2010/857685

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p> Cortical inhibition (CI) is measured by transcranial magnetic stimulation (TMS) combined with electromyography (EMG) through long-interval CI (LICI) and cortical silent period (CSP) paradigms. Recently, we illustrated that LICI can be measured from the dorsolateral prefrontal cortex (DLPFC) through combined TMS with electroencephalography (EEG). We further demonstrated that LICI had different effects on cortical oscillations in the DLPFC compared with motor cortex. The purpose of this study was to establish the validity and reliability of TMS–EEG indices of CI and to replicate our previous findings in an extended sample. The validity of TMS–EEG was examined by evaluating its relationship to standard EMG measures of LICI and the CSP in the left motor cortex in 36 and 16 subjects, respectively. Test–retest reliability was examined in 14 subjects who returned for a repeat session within 7 days of the first session. LICI was applied to the left DLPFC in 30 subjects to compare LICI in the DLPFC with that in the motor cortex. In the motor cortex, EEG measures of LICI correlated with EMG measures of LICI and CSP. All indices of LICI showed high test–retest reliability in motor cortex and DLPFC. Gamma and beta oscillations were significantly inhibited in the DLPFC but not in the motor cortex, confirming previous findings in an extended sample. These findings demonstrate that indexing LICI through TMS combined with EEG is a valid and reliable method to evaluate inhibition from motor and prefrontal regions. </jats:p>

DOI： 10.1152/jn.00279.2010

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3109/02699201003687309

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/brain/awq046

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/npp.2008.211

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/978-3-540-89506-0_11

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p>The relationship between acoustic and visual speech is important for understanding speech perception, but it also forms the basis behind a type of facial animator, which can predict facial motion during speech given an acoustic input. This relationship was examined by revisiting a linear transformation model of audio-visual speech production. A mathematical model is constructed whereby the visual aspect of speech is reproduced from the acoustic signal via a linear transformation. Unlike previous studies in this area, this paper will address specific aspects of the model as related to the effects of window size for acoustic framing and the critical size of the training set. On average, facial motion is predicted with a correlation of 0.70 to the recorded motion, when the model is trained and then tested on the same subject. This is comparable to previous studies using either similar or different model approaches. Using a model trained on other subjects and then applying it to a new subject resulted in a prediction correlation of 0.65. Furthermore, acoustic windows of 100ms and a data set of approximately 40 sentences are required for maximum predictability. The results are interpreted in terms of the underlying assumptions of the model.</jats:p>

DOI： 10.1121/1.2982369

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p><jats:bold>Abstract: </jats:bold> We have carried out experiments to explore the effect of prior knowledge and expectation on the detection of audiovisual synchrony. By expanding on earlier methodologies, we have shown that the perception of synchrony is not affected by prior knowledge of lag type (i.e., visual signal precedes audio signal or vice versa). This result suggests that higher‐level cognitive processes like expectation do not play a significant role in synchrony perception. We also introduce here a systems‐level model based on cross‐correlation that is compatible with both the observations of our experiments and with the observations of other studies.</jats:p>

DOI： 10.1111/j.1468-5884.2008.00377.x

掲載種別：研究論文（学術雑誌）  

DOI： 10.1109/TBME.2008.918439

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.specom.2007.04.011

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1037/cjep2007016

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p>We reviewed 13 papers on noise exposure of orchestral musicians and found that the question of whether orchestra musicians are overexposed does not appear to have a clear answer. To find relevant papers, we researched three databases (Scholar, Scopos, and Medline), which yielded 6,
9, and 17 papers, respectively (including duplicates). A number of papers in the reviewed literature lacked basic descriptions concerning such issues as measurement technique and instrumentation. Rough data and calculation details were often not provided so that the conclusions could not be
checked easily. The most serious problem was the estimated time that musicians performed in the orchestra. This information is crucial for the calculation of the normalized noise exposure levels (L<jats:sub>EX</jats:sub>), and is especially important as orchestra players do not perform year-round nor
are they exposed to the same noise levels while performing different pieces of music.</jats:p>

DOI： 10.21091/mppa.2006.4035

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Institute of Electrical and Electronics Engineers ({IEEE})  

DOI： 10.1109/TBME.2006.873700

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Institute of Electrical and Electronics Engineers ({IEEE})  

DOI： 10.1109/TBME.2005.851499

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.apacoust.2004.11.009

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p>A filterbank-based algorithm for time-varying spectral analysis is proposed. The algorithm, which is an enhanced realization of the conventional spectrogram, consists of hundreds or thousands of highly overlapping wideband filter/detector stages, followed by a peak detector that probes the filter/detector outputs at very short time intervals. Analysis with synthetic modulated signals illustrates how the proposed method demodulates these signals. The resulting spectrogram-like display, referred to as a “fine structure spectrogram,” shows the fine structure of the modulations in substantially higher detail than is possible with conventional spectrograms. Error evaluation is performed as a function of various parameters of a single- and two-component synthetic modulated signal, and of parameters of the analysis system. In speech, the fine structure spectrogram can detect small frequency and amplitude modulations in the formants. It also appears to identify additional significant time-frequency components in speech that are not detected by other methods, making it potentially useful in speech processing applications.</jats:p>

DOI： 10.1121/1.1896365

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1049/el:20056712

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00422-004-0516-0

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/15459620490432178

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2114/jpa.23.303

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/S0003-682X(03)00067-7

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掲載種別：研究論文（学術雑誌）  

Scopus

記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p>This paper addresses the issue of longitudinal stiffness within the cochlea. A one-dimensional model of the cochlear partition is presented in which the resonant sections are coupled by longitudinal elastic elements. These elements functionally represent the aggregate mechanical effect of the connective tissue that spans the length of the organ of Corti. With the plate-like morphology of the cochlear partition in mind, the contribution of longitudinal elasticity to partition dynamics is appreciable, though weak and nonlinear. If the elasticity is considered Hookian then the nonlinearity takes a cubic form. Numerical solutions are presented that demonstrate the compressive nature of the partial differential nonlinear equations and their ability to produce realistic cubic distortion product otoacoustic emissions. Within the framework of this model, some speculations can be made regarding the dynamical function of the phalangeal processes, the sharpness of active cochlear mechanics, and the propogation of pathology along the partition.</jats:p>

DOI： 10.1121/1.1496078

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1006/jmps.1999.1296

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1053/meta.2000.9525

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/35010196

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p>The idea of the magical number seven has been with us for over 40 years now. During this time, it has been studied extensively by both psychologists and other sensory scientists. One might be skeptical about any new results and ask “What more possibly can we say about this topic?” However, in this paper, an attempt is made to refine the interpretation of the magical number by demonstrating that it is not so much a number, but actually a “wave.” That is, independent of both experimental fluctuations and statistical bias, the magical number takes on a continuum of possible values. This prediction, made theoretically, is supported by existing experimental data. While this prediction does not amount to any significant change to the understanding of the magical number, it may however provide a criterion to judge the acceptability of any theory that purports to explain the magical number phenomenon.</jats:p>

DOI： 10.1121/1.423296

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s004220050442

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1037/h0087281

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/S0303-2647(97)00040-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3758/BF03205509

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掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）  

DOI： 10.1121/1.415225

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

<jats:p>An empirical equation from Riesz’s classic study on difference thresholds is treated in a new manner. Reformulating the expression for the Weber fraction allows one to account for the shape of the loudness function at different frequencies. Furthermore, the emerging loudness function unifies both the commonly used power and logarithmic laws of sensation. In principle, equal loudness contours can be derived from Riesz’s data. While the derived contours are imperfect, the theoretical method provides a basis for further experimental work.</jats:p>

DOI： 10.1121/1.412391

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier {BV}  

DOI： 10.1016/0025-5564(94)00024-T

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/0895-7177(93)90130-Q

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