Updated on 2025/05/02

Information

 

写真a

 
USHIMARU RICHIRO
 
Organization
Institute for Advanced Study Associate Professor
Title
Associate Professor

Papers

  • Pyrroline Ring Assembly via N-Prenylation and Oxidative Carbocyclization during Biosynthesis of Aeruginosin Derivatives

    Zhang, WH; Ushimaru, R; Kanaida, M; Abe, I

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   147 ( 13 )   10853 - 10858   2025.3   （ ISSN:0002-7863 eISSN:1520-5126 ）

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    Language：English   Publisher：Journal of the American Chemical Society  

    Aeruginosins are linear peptide natural products isolated from cyanobacteria and contain various arginine derivatives at their termini. 1-Amino-2-(N-amidino-3-Δ3-pyrrolinyl)ethane (Aeap) is a structurally unique arginine derivative, as it has an unusual pyrroline ring with two additional carbon atoms of unknown biosynthetic origin. Here, we demonstrate that Aer3, a member of a newly identified subfamily of prenyltransferases, catalyzes selective isopentenylation of the internal N atom of agmatine. Rieske oxygenase AerC then catalyzes both carbocyclization and C-C bond cleavage to construct the pyrroline ring in Aeap. This pyrroline ring formation in Aeap biosynthesis, involving two novel enzymes, represents a unique route for heterocycle formation in nature.

    DOI： 10.1021/jacs.5c01994

    Web of Science

    Scopus

    PubMed

  • Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis(タイトル和訳中)

    Mori Takahiro, Sakurada Kosuke, Awakawa Takayoshi, He Haibin, Ushimaru Richiro, Abe Ikuro

    The Journal of Antibiotics   78 ( 3 )   149 - 158   2025.3   （ ISSN:0021-8820 ）

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    Language：English   Publisher：Nature Publishing Group  

Presentations

MISC