Updated on 2025/06/18

Information

 

写真a

 
FUJIMOTO KOJI
 
Organization
Kyushu University Hospital Psychosomatic Medicine Assistant Professor
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
External link

Degree

  • 医学博士 （ 2025.3 Kyushu University ）

Research History

  • Kyushu University Kyushu University Hospital Psychosomatic Medicine  Assistant Professor 

    2025.4 - Present

Papers

  • C5a in the peripheral plasma of female fibromyalgia patients is elevated but not related to pain sensitivity as in healthy controls

    Fujimoto, K; Anno, K; Tanaka, Y; Murakami, M; Inamine, S; Kato, TA; Sudo, N; Hosoi, M

    SCIENTIFIC REPORTS   15 ( 1 )   17387   2025.5   （ ISSN:2045-2322 ）

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    Language：English   Publisher：Scientific Reports  

    Although evidence from basic studies indicates that C5a induces hyperalgesia, knowledge from studies of humans is limited. This comparative analysis of the peripheral blood C5a concentration of women diagnosed with fibromyalgia (FM) who exhibited widespread pain and that of female healthy controls (HCs) was done to assess possible correlations of C5a concentration with pain threshold. The data of 30 patients with FM and 29 HCs were included in the analysis. C5a concentration in the peripheral blood was quantified by ELISA, and the cold pain threshold (CPT) was assessed. The correlation between C5a concentration and CPT was analyzed using the Spearman correlation coefficient, and the peripheral blood C5a concentrations of FM and HC were compared by t-test. The mean (standard deviation) peripheral blood C5a concentrations of FM and HC were 12.7 (6.48) ng/ml and 8.82 (4.79) ng/ml, respectively (p = 0.0114). Although no significant relation was observed between CPT and C5a concentration in FM (R = − 0.12, p = 0.52), a significant correlation was found for HC (R = 0.41, p = 0.03). The results suggest that C5a would be a potential biomarker for the pain sensitivity of women and give new insights into the pathophysiology of FM.

    DOI： 10.1038/s41598-025-01347-x

    Web of Science

    Scopus

    PubMed

  • 低リン血症を契機にビタミンD欠乏性骨軟化症の診断に至った神経性やせ症の1例

    中村 拓也, 藤本 晃嗣, 辰島 啓太, 辻 裕美, 田村 奈穂, 河合 啓介

    心身医学   63 ( 1 )   46 - 51   2023.1   （ ISSN:0385-0307 ）

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    Language：Japanese   Publisher：(一社)日本心身医学会  

    神経性やせ症の合併症として骨粗鬆症はよく知られているが,骨軟化症の報告は少ない.今回,低リン血症を契機にビタミンD欠乏性骨軟化症の診断に至った1例を経験した.症例は50代女性.X-30年より体重減少が始まり,X年にbody mass index(BMI)10kg/m2まで低下し,神経性やせ症の診断にて当科で治療を開始した.X+4年に自宅にひきこもるようになり,同年,血清リン値が0.5mg/dlまで低下したため当科に緊急入院した.入院後,著明な低リン血症,高骨型ALP血症,骨密度低下,骨シンチグラフィ取り込み亢進(肋骨,脊椎),ビタミンD欠乏を認め,ビタミンD欠乏性骨軟化症と診断した.本症例は長期間の低栄養状態に加え,ひきこもりが骨軟化症の病態の原因であったと推察する.重篤な症状は出現しておらず,低リン血症により早期に診断できたものと考える.神経性やせ症患者はビタミンD欠乏症のハイリスクと考えられるため,骨粗鬆症だけでなく骨軟化症の可能性を考える必要がある.(著者抄録)

  • Vitamin D Deficiency Osteomalacia Related to Hypophosphatemia in a Patient with Anorexia Nervosa : A Case Report

    Nakamura Takuya, Fujimoto Koji, Tatsushima Keita, Tsuji Hiromi, Tamura Naho, Kawai Keisuke

    Japanese Journal of Psychosomatic Medicine   63 ( 1 )   46 - 51   2023   （ ISSN:03850307 eISSN:21895996 ）

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    Language：Japanese   Publisher：Japanese Society of Psychosomatic Medicine  

    <p><b>Introduction</b> : Although osteoporosis is a well-known complication of anorexia nervosa (AN), osteomalacia is presented in a few reports. We herein describe a case of vitamin D deficiency osteomalacia related to hypophosphatemia in a patient with AN.</p><p><b>Case report</b> : A woman in her 50s had a history of weight loss, with her body mass index (BMI) at one time decreasing to 10 kg/m<sup>2</sup>. She was diagnosed with AN and underwent treatment as an outpatient. She began to withdraw from society and isolated herself at home. Her serum phosphorus level decreased to 0.5 mg/d<i>l</i>, and she was admitted to our department on an emergency basis. She was diagnosed with vitamin D deficiency osteomalacia related to hypophosphatemia. She had high bone ALP level (bone specific alkaline phosphatase〔BAP〕, 29.5 µg/<i>l</i>), decreased bone density (lumbar spine young adult mean〔YAM〕, 47%), increased bone scintigraphic uptake (ribs and spine), vitamin D deficiency (25 [OH] D, 5.2 ng/m<i>l</i>), normal fibroblast growth factor 23 (FGF 23) level (15.0 ng/m<i>l</i>), and normal urine. After regaining weight through nutritional therapy, supplemental vitamin D therapy, and sunbathing, the serum phosphorus and ALP levels normalized ; subsequently, she was discharged from the hospital.</p><p><b>Discussion</b> : We speculate that the patient’s long-term low nutritional status and home isolation caused vitamin D deficiency osteomalacia. No serious symptoms developed because the hypophosphatemia allowed the diagnosis of the disease at an early stage. Because patients with AN are at high risk for vitamin D deficiency, the risk of osteomalacia as well as osteoporosis, should be considered.</p>

    DOI： 10.15064/jjpm.63.1_46

    CiNii Research

  • Chronic Pain Acceptance Questionnaire日本語版(CPAQ-J)の作成と信頼性・妥当性の検討

    安野 広三, 岩城 理恵, 村上 匡史, 藤本 晃嗣, 田中 佑, 早木 千絵, 須藤 信行, 細井 昌子

    慢性疼痛   41 ( 1 )   83 - 90   2022.12   （ ISSN:1340-2331 ）

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    Language：Japanese   Publisher：日本慢性疼痛学会  

    【背景】「慢性疼痛のアクセプタンス」は慢性疼痛の理解や治療のための重要な概念とされている。その測定にはChronic Pain Acceptance Questionnaireが最も使用されている。本研究の目的はCPAQ日本語版(CPAQ-J)の作成,その妥当性の検討であった。【方法】慢性疼痛患者243人を対象とし,CPAQ-Jおよび痛みの強度,機能障害,不安,抑うつ,痛みの破局化,生活の質,生活満足度につき回答してもらった。【結果】CPAQ-Jはスクリープロット,主因子法により英語原版と同様の2因子構造を示し,十分な内的整合性(Cronbach α係数0.83)と再検査信頼性(級内相関係数0.88)が示された。また,痛みの強度,機能障害,不安,抑うつ,痛みの破局化,生活の質,生活満足度と有意な関連を認めた。【結論】本研究でCPAQ-Jは我が国の慢性疼痛患者において,十分な信頼性と妥当性が示された。(著者抄録)

  • 日本における摂食障害治療支援センターの重要性　2017～2020年の調査(The importance of an eating disorder treatment support center in Japan: A survey from 2017 to 2020)

    Kawai Keisuke, Kojima Yuka, Yamamoto Yurie, Fujimoto Koji, Tamura Naho, Oya Toshiki, Tachimori Hisateru

    Global Health & Medicine   4 ( 3 )   152 - 158   2022.6   （ ISSN:2434-9186 ）

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    Language：English   Publisher：(国研)国立国際医療研究センター  

    千葉県摂食障害(ED)治療支援センター(CSC)設置後に当院を受診した患者の臨床状況の変化を調べた。2017～2020年のCSCでの相談件数、当院紹介患者の割合を調べた。CSCが設置される1年前の2016年から2020年までの4年間における当院の外来または入院患者数も調べた。入院患者については入院期間、入院時と退院時のBMIも調べた。患者の要望に応じた適切な医療機関の調査と紹介の医療連携システムの推進によって、CSCの相談件数は毎年増加したが、当院以外の医療機関への紹介率も増加した。同じ期間に当院における外来患者と入院患者の数の減少がみられた。当院で治療を受けた神経性やせ症(AN)患者では入院期間中に有意な体重増加がみられたが、これは以前殺到していたED患者が分散したことで重症患者を効果的に治療することが可能となったことを示していた。前の3年間に比べて2019年に入院期間が延長したが、これは体重増加の治療法が可能となったことに起因すると推測された。2018年には全国のセンターで外来相談件数がピークとなり、その後減少した。当院を受診した患者数も2019年に30%減少した。2019年における全国のセンターのAN患者の年齢は有意に低く、千葉県でもその傾向がみられた。SNSを活用した広報活動、医療機関の協力によって、ED患者は直接CSCを見つけて相談することが容易となった。

  • Psychological Traits of Patients With Depression Comorbid With Chronic Pain: Are Complaint and Competitive Tendency Related to Pain?

    Fujimoto, K; Hosoi, M; Katsuki, R; Matsushima, T; Matsuo, K; Nakao, T; Sudo, N; Kato, TA

    FRONTIERS IN PSYCHIATRY   13   825422   2022.2   （ ISSN:1664-0640 ）

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    Language：English   Publisher：Frontiers in Psychiatry  

    Background: Modern-Type Depression (MTD) is a category of depression that has been studied mainly in Japan; however, no study has attempted to determine its relation to chronic pain. Aim: To determine possible associations between psychological traits related to MTD and the chronic pain of patients at psychiatric clinics. Method: Two hundred and twenty-one first time patients who visited the psychiatric clinic at a Japanese university medical center or an associated clinic were enrolled. The Hamilton Depression Rating Scale was used to measure depressive symptoms. The 22-item Tarumi's Modern-Type Depression Trait Scale (TACS-22), Achievement Motive, and 20-item Toronto Alexithymia Scale were used to assess psychological traits related to depression and chronic pain. The clinical diagnosis of each patient was confirmed by use of the Structured Clinical Interview for DSM-IV Axis I Disorders, administered by experienced specialists. The medians of the psychological traits identified were compared between patients with or without chronic pain. Analysis was also done of patients with Major Depressive Disorder (MDD). Result: Of the 221 patients, 139 had chronic pain. Patients with chronic pain had more severe depressive symptoms, Alexithymia, and high scores for the complaint trait of MTD. Seventy-three of the 221 patients met the criteria for MDD (53 had chronic pain). Patients with MDD comorbid with chronic pain had a higher competitive achievement score, severe depression, and difficulty identifying feelings. Conclusion: Complaint and competitive traits were shown to be related to chronic pain in psychiatric settings. Further study will allow us to design multidimensional approach for patients suffering from depression.

    DOI： 10.3389/fpsyt.2022.825422

    Web of Science

    Scopus

    PubMed

  • Narrative Review of the Pathophysiology of Chronic Pain with a Focus on Neuroinflammation

    Fujimoto Koji, Hosoi Masako

    Japanese Journal of Psychosomatic Medicine   62 ( 1 )   50 - 56   2022   （ ISSN:03850307 eISSN:21895996 ）

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    Language：Japanese   Publisher：Japanese Society of Psychosomatic Medicine  

    <p>Insight regarding the mechanism of chronic pain without a diagnosed underlying disease is expanding, particularly where neuroinflammation is concerned. Neuroinflammation occurs in the central nervous system. Recent understanding of neuroinflammation has developed dramatically for some diseases. New therapies, such as anti-C5 antibody therapy for neuromyelitis optica spectrum disorders, have been introduced into clinical practice to target neuroinflammation. The association between glial activation and inflammatory mediators in chronic pain has long been studied. Inflammatory mediators produced by activated glial cells in the central nervous system enhance neural activity, resulting in hypersensitivity.</p><p>The 18kDa-translocator protein is an emerging ligand used in PET studies to show glial activation. Stronger PET signals have been detected in certain brain areas of study participants with chronic pain. Such studies are expected to deepen our understanding of the pathophysiology of chronic pain.</p><p>Synaptic pruning is a phenomenon through which synapses are eliminated by glial cells. It is believed to be associated with the development of schizophrenia and autism spectrum disorders, and studies show it is related to learning and memory. Synaptic pruning may also play a role in some types of chronic pain. Big data studies of genes related to chronic pain indicate common risk factors, including depression, post-traumatic stress disorder, and autoimmune diseases. Understanding of the chronic pain mechanisms is deepening, and the development of new biomarkers and treatments that are useful in the clinical setting can be expected in the near future.</p>

    DOI： 10.15064/jjpm.62.1_50

    CiNii Research

  • Chronic Pain and Modern-Type Depression

    A. Kato Takahiro, Fujimoto Koji, Hosoi Masako

    Japanese Journal of Psychosomatic Medicine   62 ( 5 )   394 - 400   2022   （ ISSN:03850307 eISSN:21895996 ）

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    Language：Japanese   Publisher：Japanese Society of Psychosomatic Medicine  

    <p>Modern-Type Depression (MTD) is an emerging type of depression in Japan. Some unique psychological traits related to MTD are known ; however, no study has attempted to determine their relation with chronic pain. We introduced a recently published cross-sectional study to determine possible associations between these psychological traits and chronic pain in patients at psychiatric clinics (Fujimoto et al., Front Psychiatry, 2021). A total of 221 first-time patients who visited the psychiatric clinic at a Japanese university medical center or an associated clinic were enrolled. The Hamilton Depression Rating Scale was used to assess the depressive symptoms. The 22-item Tarumi’s Modern-Type Depression Trait Scale and 20-item Toronto Alexithymia Scale were used to assess the psychological traits related to depression and chronic pain. The clinical diagnosis of each patient was confirmed using Structured Clinical Interview for DSM-IV Axis I Disorders, administered by experienced specialists. The medians obtained for the psychological traits were compared between patients with or without chronic pain. Among the 221 patients, 139 had chronic pain. Patients with chronic pain had more severe depressive symptoms, alexithymia, and high scores for the complaints of TACS-22. Complaint trait for MTD was shown to be related to chronic pain in psychiatric settings. Further studies will allow us to design multidimensional approach for patients suffering from depression.</p>

    DOI： 10.15064/jjpm.62.5_394

    CiNii Research

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Presentations

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MISC

  • 慢性疼痛におけるうつ病の影響

    藤本 晃嗣, 加藤 隆弘

    Depression Strategy   14 ( 2 )   1 - 4   2024.4   （ ISSN:2186-2575 ）

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    Language：Japanese   Publisher：(株)先端医学社  

  • 慢性疼痛と心理社会的ストレス:from Bed to Bench　慢性疼痛と新型/現代型うつ

    加藤 隆弘, 藤本 晃嗣, 細井 昌子

    心身医学   62 ( 5 )   394 - 400   2022.9   （ ISSN:0385-0307 ）

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    Language：Japanese   Publisher：(一社)日本心身医学会  

    背景:うつ病と慢性疼痛の関連は以前より示唆されているが、新型/現代型うつ(以下MTD)と慢性疼痛との関連を検討した研究はない。目的:MTDに関連する心理特性と精神科受診者の慢性疼痛との関連性を検討した論文(FujimotoらFront Psychiatry 2021)を紹介する。方法:大学病院または関連病院の精神科外来を受診した初診患者221名を対象とした。抑うつ症状の測定にはハミルトンうつ病評価尺度を用いた。心理的特性は22項目版現代うつ気質尺度(TACS-22)と20項目版トロント・アレキサイミア尺度(TAS-20)で評価した。測定項目の中央値を慢性疼痛の有無で比較した。結果:221名の患者のうち139名が慢性疼痛を有していた。慢性疼痛を有する患者は、抑うつ症状、感情同定困難(TAS-20下位項目)、そしてMTDの不平不満傾向(TACS-22下位項目)が高得点であった。結論:精神科臨床での慢性疼痛には、MTDに関連する心理特性である不平不満傾向が関係していることが示唆された。(著者抄録)

  • 【各領域における最新の心身相関について】慢性疼痛の神経炎症を中心とした生物学的基盤

    藤本 晃嗣, 細井 昌子

    心身医学   62 ( 1 )   50 - 56   2022.1   （ ISSN:0385-0307 ）

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    Language：Japanese   Publisher：(一社)日本心身医学会  

    器質的疾患を指摘できない慢性疼痛において、近年その生物学的基盤が明らかになりつつある。特に注目を浴びているのが、神経炎症である。視神経脊髄炎スペクトラム障害などの脱髄疾患を中心として神経炎症との関連が明らかになるにつれ、病態に基づいた治療が実臨床に導入されつつある。慢性疼痛においても炎症メディエーターやミクログリアの関与が知られているが、近年グリア細胞の活性をin vivoで評価できる18kDa-translocator protein(TSPO)をリガンドとして用いたPET検査が行われるようになり、病態の解明が進んでいる。また、統合失調症や自閉症スペクトラム障害での関与が疑われているシナプス刈り込みも慢性疼痛の病態形成に関与している可能性がある。遺伝子ビッグデータを用いた研究においても、抑うつ、PTSDや自己免疫性疾患との関連が確認された。近い将来、慢性疼痛の生物学的基盤の理解がさらに進み、臨床的場面で有用なバイオマーカーの開発につながることを期待する。(著者抄録)

Educational Activities

  • 2025～心療内科教育主任として主に学生実習などのマネージメントを担当

Clinician qualification

  • Certifying physician

    The Japanese Society of Internal Medicine（JSIM）

  • Specialist

    Japanese Society of Psychosomatic Medicine（JSPM）

Year of medical license acquisition

  • 2015