Faculty Profiles - TSUCHIKAWA HIROSHI

Information

写真a

TSUCHIKAWA HIROSHI

Organization

Faculty of Science Department of Chemistry Associate Professor
School of Sciences Department of Chemistry（Concurrent）
Graduate School of Sciences Department of Chemistry（Concurrent）

Contact information

Homepage

http://www.scc.kyushu-u.ac.jp/Seibutsuyuki/index.html

Research Areas

Nanotechnology/Materials / Synthetic organic chemistry
Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules
Life Science / Pharmaceutical chemistry and drug development sciences

Degree

Ph.D. （ 2006.12 Osaka University ）

Research History

Oita University Faculty of Medicine Specially Appointed Lecturer

2020.5 - 2024.3
Oita University 全学研究推進機構客員研究員

2019.6 - 2020.4
Osaka University 大学院理学研究科化学専攻 Assistant Professor

2010.6 - 2019.5

Education

Osaka University 大学院理学研究科化学専攻

2003.4 - 2006.12
Osaka University 大学院理学研究科化学専攻

2001.4 - 2003.3
Kwansei Gakuin University 理学部化学科

1997.4 - 2001.3

Research Interests・Research Keywords

Research theme： Total synthesis of natural product and elucidation of its mode of action

Keyword： Organic synthesis, Molecular probes, Structural analysis

Research period： 2001.4 - Present
Research theme： Peptidomimetics

Keyword： Compound library, Small Molecule Drug Discovery

Research period： 2020.5 - Present
Research theme： Structure and function analysis of membrane-active compounds based on organic synthesis

Keyword： Synthesis of labeled compounds, Interaction analysis, Analysis of membrane physical properties, Deuterium solid-state NMR

Research period： 2010.6 - 2025.3

Awards

第90回春季年会優秀講演賞

2010.3 日本化学会

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Award type：Award from Japanese society, conference, symposium, etc. Country：Japan

Papers

NMR and molecular simulation studies on the structure elucidation of the amphotericin B ion channel using ¹³C and ¹⁹F labelling

Yuichi Umegawa, Hiroshi Tsuchikawa, Wataru Shinoda, Michio Murata

Organic & Biomolecular Chemistry 2024.11 （ ISSN:1477-0520 eISSN:1477-0539 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：Royal Society of Chemistry (RSC)

Solid-state NMR spectra of <sup>13</sup>C- and <sup>19</sup>F-labelled amphotericin B reveal that seven molecules form an ion channel assembly with ergosterol. Molecular dynamics simulations show this channel generates ion currents consistent with experiments.

DOI： 10.1039/d4ob01468e
LnDOTA d8, a versatile chemical‐shift thermometer for ²H solid‐state NMR

Yuichi Umegawa, Takeshi Shimonishi, Hiroshi Tsuchikawa, Michio Murata

Magnetic Resonance in Chemistry 2022.8 （ ISSN:0749-1581 eISSN:1097-458X ）

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Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1002/mrc.5303

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mrc.5303
Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study

Umegawa, Y; Yamamoto, T; Dixit, M; Funahashi, K; Seo, S; Nakagawa, Y; Suzuki, T; Matsuoka, S; Tsuchikawa, H; Hanashima, S; Oishi, T; Matsumori, N; Shinoda, W; Murata, M

SCIENCE ADVANCES 8 ( 24 ) eabo2658 2022.6 （ ISSN:2375-2548 ）

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Language：English Publisher：Science Advances

Amphotericin B, an antifungal drug with a long history of use, forms fungicidal ion-permeable channels across cell membranes. Using solid-state nuclear magnetic resonance spectroscopy and molecular dynamics simulations, we experimentally elucidated the three-dimensional structure of the molecular assemblies formed by this drug in membranes in the presence of the fungal sterol ergosterol. A stable assembly consisting of seven drug molecules was observed to form an ion conductive channel. The structure is somewhat similar to the upper half of the barrel-stave model proposed in the 1970s but substantially different in the number of molecules and in their arrangement. The present structure explains many previous findings, including structure-activity relationships of the drug, which will be useful for improving drug efficacy and reducing adverse effects.

DOI： 10.1126/sciadv.abo2658

Web of Science

Scopus

PubMed
Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers. International journal

Hiroshi Tsuchikawa, Mami Monji, Yuichi Umegawa, Tomokazu Yasuda, J Peter Slotte, Michio Murata

Langmuir : the ACS journal of surfaces and colloids 38 ( 18 ) 5515 - 5524 2022.5

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The chain melting of lipid bilayers has often been investigated in detail using calorimetric methods, such as differential scanning calorimetry (DSC), and the resultant main transition temperature is regarded as one of the most important parameters in model membrane experiments. However, it is not always clear whether the hydrocarbon chains of lipids are gradually melting along the depth of the lipid bilayer or whether they all melt concurrently in a very narrow temperature range, as implied by DSC. In this study, we focused on stearoyl-d-sphingomyelin (SSM) as an example of raft-forming lipids. We synthesized deuterium-labeled SSMs at the 4', 10', and 16' positions, and their depth-dependent melting was measured using solid-state deuterium NMR by changing the temperature by 1.0 °C, and comparing with that observed from a saturated lipid, palmitoylstearoylphosphatidylcholine (PSPC). The results showed that SSM exhibited a characteristic depth-dependent melting, which was not observed for PSPC. The strong intermolecular hydrogen bonds between the sphingomyelin amide moiety probably caused the chain melting to start from the chain terminus through the middle part and end in the upper part. This depth-dependent melting implies that the small gel-like domains of SSM remain at temperatures slightly above the main transition temperature. These sphingomyelin features may be responsible for the biological properties of SM-based lipid rafts.

DOI： 10.1021/acs.langmuir.2c00092

PubMed
Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers

Shinya Hanashima, Ryuji Ikeda, Yuki Matsubara, Tomokazu Yasuda, Hiroshi Tsuchikawa, J. Peter Slotte, Michio Murata

Biophysical Journal 121 ( 7 ) 1143 - 1155 2022.4 （ ISSN:0006-3495 ）

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.bpj.2022.02.037
Conformation and Orientation of Branched Acyl Chains Responsible for the Physical Stability of Diphytanoylphosphatidylcholine. Reviewed

Hiroshi Tsuchikawa; Takuya Ono; Masaki Yamagami; Yuichi Umegawa; Wataru Shinoda; Michio Murata

Biochemistry 59 3929 - 3938 2020.9

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1021/acs.biochem.0c00589
Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains. Reviewed International coauthorship

Yo Yano; Shinya Hanashima; Hiroshi Tsuchikawa; Tomokazu Yasuda; J. Peter Slotte; Erwin London; Michio Murata

Biophysical Journal 119 ( 3 ) 539 - 552 2020.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bpj.2020.06.028
Chemical synthesis, structure determination, and evaluation of biological activity of sperm activating and attracting factors isolated from ascidias Reviewed

Hiroshi Tsuchikawa, Tohru Oishi

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 78 ( 3 ) 213 - 220 2020.3

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.5059/yukigoseikyokaishi.78.213
The Amphotericin B–Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly Reviewed

Tomoya Yamamoto; Yuichi Umegawa; Hiroshi Tsuchikawa; Shinya Hanashima; Nobuaki Matsumori; Kosuke Funahashi; Sangjae Seo; Wataru Shinoda; Michio Murata

Biochemistry 58 ( 51 ) 5188 - 5196 2019.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1021/acs.biochem.9b00835
Synthesis of 7,6-Spirocyclic Imine with Butenolide Ring Provides Evidence for the Relative Conﬁguration of Marine Toxin 13-desMe Spirolide C Reviewed

Kou Minamino; Michio Murata; Hiroshi Tsuchikawa

Organic Letters 21 ( 22 ) 8970 - 8975 2019.10

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1021/acs.orglett.9b03373
Impact of acyl chain mismatch on the formation and properties of sphingomyelin-cholesterol domains Reviewed International coauthorship

Nyholm, Thomas K. M.; Engberg, Oskar; Hautala, Victor; Tsuchikawa, Hiroshi; Lin, Kai-Lan; Murata, Michio; Slotte, J. Peter

Biophysical Journal 117 1577 - 1588 2019.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.1016/j.bpj.2019.09.025
Average Conformation of Branched Chain Lipid PGP-Me That Accounts for the Thermal Stability and High-Salinity Resistance of Archaeal Membranes Reviewed

Masaki Yamagami; Hiroshi Tsuchikawa; Jin Cui; Yuichi Umegawa; Yusuke Miyazaki; Sangjae Seo; Wataru Shinoda; Michio Murata

Biochemistry 58 3869 - 3879 2019.9

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning Reviewed

Shinya Hanashima; Yuki Ibata; Hirofumi Watanabe; Tomokazu Yasuda; Hiroshi Tsuchikawa; Michio Murata

Organic & Biomolecular Chemistry 17 8601 - 8610 2019.9

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Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.1039/C9OB01342C
Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup Reviewed

Shinya Hanashima, Kazuhiro Murakami, Michihiro Yura, Yo Yano, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Sangjae Seo, Wataru Shinoda, Michio Murata

Biophysical Journal 117 307 - 318 2019.6

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Language：English Publishing type：Research paper (scientific journal)
The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model Reviewed

Tomoya Yamamoto; Yuichi Umegawa; Masaki Yamagami; Taiga Suzuki; Hiroshi Tsuchikawa; Shinya Hanashima; Nobuaki Matsumori; Michio Murata

Biochemistry 58 ( 17 ) 2282 - 2291 2019.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1021/acs.biochem.9b00180
Small structural alterations greatly influence the membrane affinity of lipophilic ligands Reviewed

Tatsuru Hayashi; Hiroshi Tsuchikawa; Yuichi Umegawa; Michio Murata

Bioorganic & Medicinal Chemistry 27 1677 - 1682 2019.3

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Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.1016/j.bmc.2019.03.017

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Books

有機合成実験法ハンドブック第２版第11章クロマトグラフィーによる分析と分取

土川博史, 田中克典（Role：Contributor）

丸善出版株式会社 2015

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Language：Japanese Book type：Textbook, survey, introduction
有機合成実験法ハンドブック第２版　第12章機器分析による分析

土川博史, 難波康祐, 中尾佳亮, 田中克典（Role：Contributor）

丸善出版株式会社 2015

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Language：Japanese Book type：Textbook, survey, introduction

Presentations

Synthesis of a Novel Tetraaza-trione Compound Based on Peptidomimetics and Its Antiviral Activity

〇土川博史, 加藤明良, 山田健太郎, 松岡茂

第35回万有福岡シンポジウム 2025.6 万有福岡シンポジウム組織委員会

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Event date： 2025.6

Language：Japanese Presentation type：Poster presentation

Venue：九州大学医学部百年講堂 Country：Japan
Synthesis of a Novel Tetraaza-trione Compound Based on Peptidomimetics and Its Antiviral Activity

南野宏, ○土川博史, 林翔, 島田紀子, 此木敬一,村田道雄

第62回天然有機化合物討論会 2020.9 万有福岡シンポジウム組織委員会

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Event date： 2020.9

Language：Japanese Presentation type：Poster presentation

Venue：オンライン開催 Country：Japan
古細菌脂質 PGP-Me が形成する二重膜の構造解析による特徴的な膜物性の解明 Invited

土川博史

第 3 回生体膜と生体モデル膜セミナー 2019.12 大阪大学理学研究科

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Event date： 2019.12

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：大阪大学理学研究科 Country：Japan
Synthesis of a Novel Tetraaza-trione Compound Based on Peptidomimetics and Its Antiviral Activity

山上正輝, ○土川博史, Jin Cui, 梅川雄一, 宮崎裕介, Sangjae Seo, 篠田渉, 村田道雄

第61回天然有機化合物討論会 2019.9 天然有機化合物討論会実行委員会

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Event date： 2019.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：広島 Country：Japan
天然物リガンドの合成を基盤とした脂質二重膜および膜タンパク質との相互作用解析 Invited

土川博史

理工学部講演会 2019.6

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Event date： 2019.6

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：関西学院大学 Country：Japan
Analysis of Inhibitory Mechanism of Bafilomycin against Vacuolar-type ATPase by Solid-state NMR International conference

土川博史

2018 Bilateral Symposium 2018.10 大阪大学

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Event date： 2018.10

Language：English Presentation type：Oral presentation (general)

Venue：大阪大学 Country：Japan
Membrane Behavior of Very Long Chain Sphingomyelin in Lipid Bilayers Deduced from Solid State NMR International conference

〇H. Tsuchikawa, M. Moriuchi, M. Adachi, J. P. Slotte, M. Murata

International Workshop on Biological Membranes 2018.8

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Event date： 2018.8

Language：English Presentation type：Poster presentation

Venue：Helsinki Country：Finland
Synthesis of a Novel Tetraaza-trione Compound Based on Peptidomimetics and Its Antiviral Activity

〇土川博史・森内舞・安田智一・村田道雄・Slotte J. Peter

第12回スフィンゴテラピィー研究会 2017.7 天然有機化合物討論会実行委員会

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Event date： 2017.7

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：石川 Country：Japan
Design, synthesis and biological evaluation of fluorinated bafilomycin analogues as an NMR probe to analyze the interaction with vacuolar-type ATPase International conference

〇H. Tsuchikawa, H. Shibata, T. Hayashi, S, Hanashima, N. Matsumori, M. Murata, T. Usui

Pacifichem 2015 2015.12

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Event date： 2015.12

Language：English Presentation type：Oral presentation (general)

Venue：Honolulu, Hawaii Country：United States
微生物由来の生理活性天然物およびその誘導体合成を基盤とした結合タンパク質解析 Invited

土川博史

プレ戦略イニシアティブ（研究拠点提案型）「生物機能の高度化を目指した応用微生物研究拠点」第3回セミナー 2013.9

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Event date： 2013.9

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：筑波大学 Country：Japan
脂質膜中で形成される分子複合体の構造解析を目指した標識化天然物の合成研究 Invited

土川博史

関学化学フォーラム 2013.1

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Event date： 2013.1

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：関西学院大学 Country：Japan
Development of SN2' reaction arising from the unique sugar structure and its application to the synthesis of difluoromethylene-linked disaccharide unit

〇Hiroshi Tsuchikawa, Go Hirai, Mikiko, Sodeoka

Pacifichem 2010 2010.12

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Event date： 2010.12

Language：English Presentation type：Poster presentation

Venue：Honolulu, Hawaii Country：United States

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MISC

マススペクトロメトリーによる薬物－脂質－膜タンパク質相互作用の直接観測 Reviewed

土川博史

ファルマシア 54 ( 12 ) 1163 - 1163 2018

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

Professional Memberships

日本化学会

2002.1 - Present
有機合成化学協会

2002 - Present
American Chemical Society

2002 - Present

Committee Memberships

天然物化学談話会世話人

2010.7 - 2023.6

Academic Activities

第35回万有福岡シンポジウム実行委員

Role(s)： Planning, management, etc.

万有福岡シンポジウム組織委員会 2025.6

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Type：Competition, symposium, etc.

Number of participants：380
学術論文等の審査 International contribution

Role(s)： Review, evaluation

2025.1 - Present

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：1
第55回天然物化学談話会 (オンライン開催)　実行委員

Role(s)： Planning, management, etc.

2022.6

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Type：Academic society, research group, etc.
日本化学会第99春季年会　プログラム編成委員

Role(s)： Planning, management, etc.

日本化学会 2018.9

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Type：Academic society, research group, etc.
第53回天然物化学談話会　実行委員

Role(s)： Planning, management, etc.

2018.7

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Type：Academic society, research group, etc.

Number of participants：250
The 8th International Conference on Cutting-Edge Organic Chemistry in Asia 運営補助

Role(s)： Planning, management, etc.

2013.11

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Type：Academic society, research group, etc.

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Other

大分大学医学部　客員研究員

2025.4 - Present
大分大学全学研究推進機構　客員研究員

2019.6 - 2020.5

Research Projects

新医薬品創出に資する生体高分子局所構造の低分子模倣技術の開発

Grant number：23ak0101198h0001 2023.4 - 2026.3

日本医療研究開発機構日本医療研究開発機構創薬基盤推進研究事業

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Authorship：Coinvestigator(s) Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
生体の非平衡系を再現できる脂質二重膜の構築と動的脂質集合体の描像

Grant number：21H04707 2021.4 - 2024.3

科学研究費助成事業基盤研究(A)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
受容体アンタゴニストの低分子化

2020.6 - 2021.6

株式会社大分大学先端医学研究所

土川博史

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Grant type：Joint research
新規低分子ペプチドミメティクス設計法の開発と検証

Grant number：22ak0101138h0003 2020.4 - 2023.3

日本医療研究開発機構創薬基盤推進研究事業創薬基盤推進研究事業

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Authorship：Coinvestigator(s) Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
新規活性物質の創出に向けた天然物活性中心骨格を起点とするタンパク質の機能制御

Grant number：20K05730 2020.4 - 2022.3

科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
天然物リガンドを利用した生体膜経由の化学シグナル伝達機構の解明

Grant number：17H06406 2017.4 - 2021.3

科学研究費助成事業新学術領域研究（研究領域提案型）（計画研究）

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
生体モデル膜における脂質分子の動的配座とドメイン構造

Grant number：16H06315 2016.4 - 2020.3

科学研究費助成事業基盤研究(S)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
標識化バフィロマイシン誘導体の合成を基盤とした液胞型ATPアーゼ阻害機構の解明

Grant number：15K01821 2015.4 - 2017.3

科学研究費助成事業基盤研究(C)

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Authorship：Principal investigator Grant type：Scientific research funding
生体膜構成脂質の機能を探る小分子の再発見と作用機構の解明

Grant number：25242073 2013.4 - 2015.3

科学研究費助成事業基盤研究(A)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
強力なアセチルコリン受容体阻害活性を有するスピロリドCの全合成とその作用機構解明

Grant number：24710249 2012.4 - 2014.3

科学研究費助成事業若手研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
有機合成化学的手法によるホヤ精子活性化・誘引物質の作用機構解明

Grant number：03J04303 2003.4 - 2006.3

日本学術振興会特別研究員奨励費

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Authorship：Principal investigator Grant type：Scientific research funding

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Class subject

有機化学実験

2025.4 - 2025.6 Spring quarter

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

2025 大分大学医学部 Classification:Part-time lecturer Domestic/International Classification:Japan

Participation in international educational events, etc.

2018.11

Mahidol University

Mahidol Osaka Minisymposium

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Venue：Bangkok, Thailand

Other educational activity and Special note

2023 Lecture at Education Method and Practice 大阪大学　招へい教員
2022 Lecture at Education Method and Practice 大阪大学　招へい教員
2021 Lecture at Education Method and Practice 大阪大学　招へい教員
2020 Lecture at Education Method and Practice 大阪大学　招へい教員

Outline of Social Contribution and International Cooperation activities

I actively engage in educational outreach by giving lectures and organizing hands-on chemistry experiments for high school students, aiming to spark their interest in science. I also participate in public events such as open campus days, where I present the appeal and significance of natural products chemistry in an accessible way, helping to communicate the excitement and importance of scientific research to the broader community.

Social Activities

Ji4pe.Tokyo PE Expert C コース(オンライン講義)

Role(s)：Lecturer

一般社団法人医療開発基盤研究所 2020.10 - 2023.6
サイエンスリサーチ(サイエンスツアーII)

Role(s)：Lecturer,　Advisor,　Organizing member

2018.9
JSTグローバルサイエンスキャンパス(GSC) 大阪大学SEEDSプログラム「体感科学研究」指導教員

Role(s)：Advisor

2017.10
サイエンスリサーチ(サイエンスツアーII)

Role(s)：Lecturer,　Advisor,　Organizing member

2017.9 - 2017.10
「JSPS ひらめき☆ときめきサイエンス　大阪大学理学部化学科　一日体験入学」

Role(s)：Advisor

大阪大学 2017.8
JSTグローバルサイエンスキャンパス(GSC) 大阪大学SEEDSプログラム「体感科学研究」指導教員

Role(s)：Advisor

2016.10
サイエンスリサーチ(サイエンスツアーII)

Role(s)：Lecturer,　Advisor,　Organizing member

2016.9
生理活性天然物およびその標識化誘導体の合成を基盤とした分子複合体構造解析

Role(s)：Lecturer

大阪大学大学院薬学研究科研究室セミナー 2015.10
サイエンスリサーチ(サイエンスツアーII)

Role(s)：Lecturer,　Advisor,　Organizing member

2015.9
「JSPS ひらめき☆ときめきサイエンス　大阪大学理学部化学科　一日体験入学」

Role(s)：Advisor

大阪大学 2015.8
大阪大学未来基金「学部学生による自主研究奨励事業」アドバイザー教員

Role(s)：Advisor

大阪大学 2015.7 - 2015.11
サイエンスリサーチ(サイエンスツアーII)

Role(s)：Lecturer,　Advisor,　Organizing member

2014.9
平成25年度高大連携・化学教育セミナー

Role(s)：Lecturer

大阪大学 2013.12

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Media Coverage

大分大学発創薬ベンチャーによる低分子医薬 Newspaper, magazine

日刊工業新聞 2024.3

Travel Abroad

2018.11

Staying countory name 1：Thailand Staying institution name 1：Mahidol University
2018.8

Staying countory name 1：Finland Staying institution name 1：Åbo Akademi
2018.8

Staying countory name 1：Finland Staying institution name 1：University of Helsinki
2011.12 - 2012.3

Staying countory name 1：United States Staying institution name 1：Scripps Institution of Oceanography
2011.3

Staying countory name 1：United States Staying institution name 1：Ventura Beach Marriott