Updated on 2025/06/09

Information

 

写真a

 
EGAWA SHIRO
 
Organization
Faculty of Agriculture Department of Bioresource Sciences Assistant Professor
Graduate School of Bioresource and Bioenvironmental Sciences Department of Agro-environmental Sciences（Concurrent）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioresource Sciences（Concurrent）
School of Agriculture Department of Bioresource and Bioenvironment（Concurrent）
Title
Assistant Professor

Research Areas

  • Life Science / Animal life science

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

  • Life Science / Laboratory animal science

  • Life Science / Morphology and anatomical structure

  • Life Science / Developmental biology

  • Life Science / Anatomy

  • Life Science / Evolutionary biology

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Research History

  • Kyushu University Faculty of Agriculture Assistant Professor 

    2025.4 - Present

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    Country：Japan

  • National Center of Neurolgy and Psychiatry National Institute of Neuroscience 科研費研究員/リサーチフェロー 

    2022.5 - 2025.3

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    Country：Japan

    Notes：Department of Neurophysiology

  • RIKEN Center for Biosystems Dynamics Research Special Postdoctoral Researcher 

    2019.5 - 2022.4

  • Yale University Peabody Museum of Natural History Postdoctorral Associate 

    2018.11 - 2019.4

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    Country：United States

  • Yale University Peabody Museum of Natural History visiting researcher 

    2018.7 - 2018.10

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    Country：United States

  • Tohoku University Graduate School of Life Sciences postdoctoral fellow 

    2018.4 - 2018.10

  • Japan Society for the Promotion of Science  Doctoral Research Fellow (DC1) 

    2015.4 - 2018.3

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Education

  • Tohoku University   Graduate School of Life Sciences  

    2014.10 - 2018.4

  • Tohoku University   Graduate School of Life Sciences  

    2012.10 - 2014.9

  • Waseda University   School of Advanced Science and Engineering  

    2008.4 - 2012.3

Research Interests・Research Keywords

  • Research theme： 運動器

    Keyword： 運動器

    Research period： 2025

  • Research theme： 動物生体機構

    Keyword： 動物生体機構

    Research period： 2025

  • Research theme： 家禽

    Keyword： 家禽

    Research period： 2025

  • Research theme： dinosaurs

    Keyword： dinosaurs

    Research period： 2025

  • Research theme： 比較解剖学

    Keyword： 比較解剖学

    Research period： 2025

  • Research theme： 発生生物学

    Keyword： 発生生物学

    Research period： 2025

  • Research theme： neurophysiology

    Keyword： neurophysiology

    Research period： 2025

  • Research theme： evo-devo

    Keyword： evo-devo

    Research period： 2025

  • Research theme： motor control

    Keyword： motor control

    Research period： 2025

Awards

  • 基礎特別科学研究員成果発表会 優秀賞 (生物学部門)

    2022.1   理化学研究所  

  • Award of Aoba science promotion association

    2018.3   Tohoku University  

  • Excellent Poster Award in 166th meeting

    2017.1   Palaeontological Society of Japan  

    受賞対象発表演題「実験発生学的観点からの恐竜研究」

Papers

  • Author Correction: The developing bird pelvis passes through ancestral dinosaurian conditions (Nature, (2022), 608, 7922, (346-352), 10.1038/s41586-022-04982-w)

    Griffin, C.T., Botelho, J.F., Hanson, M., Fabbri, M., Smith-Paredes, D., Carney, R.M., Norell, M.A., Egawa, S., Gatesy, S.M., Rowe, T.B., Elsey, R.M., Nesbitt, S.J., Bhullar, B.-A.S.

    Nature   623 ( 7989 )   E19   2023   （ ISSN:1476-4687 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41586-023-06765-3

    Scopus

  • The dinosaurian femoral head experienced a morphogenetic shift from torsion to growth along the avian stem Reviewed

    Egawa, S., Griffin, C.T., Bishop, P.J., Pintore, R., Tsai, H.P., Botelho, J.F., Smith-Paredes, D., Kuratani, S., Norell, M.A., Nesbitt, S.J., Hutchinson, J.R., Bhullar, B.-A.S.

    Proceedings of the Royal Society B: Biological Sciences   289 ( 1984 )   2022.10   （ ISSN:1471-2954 ）

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1098/rspb.2022.0740

    Scopus

  • The developing bird pelvis passes through ancestral dinosaurian conditions Reviewed

    Christopher T. Griffin, João F. Botelho, Michael Hanson, Matteo Fabbri, Daniel Smith-Paredes, Ryan M. Carney, Mark A. Norell, Shiro Egawa, Stephen M. Gatesy, Timothy B. Rowe, Ruth M. Elsey, Sterling J. Nesbitt, Bhart-Anjan S. Bhullar

    Nature   608 ( 7922 )   346 - 352   2022.7   （ ISSN:0028-0836 eISSN:1476-4687 ）

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41586-022-04982-w

    Other Link： https://www.nature.com/articles/s41586-022-04982-w

  • Homeobox code model of heterodont tooth in mammals revised Reviewed

    Wakamatsu, Y., Egawa, S., Terashita, Y., Kawasaki, H., Tamura, K., Suzuki, K.

    Scientific Reports   9 ( 1 )   2019.9   （ ISSN:2045-2322 ）

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media {LLC}  

    DOI： 10.1038/s41598-019-49116-x

    Scopus

  • Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum Reviewed

    Egawa, S., Saito, D., Abe, G., Tamura, K.

    Royal Society Open Science   5 ( 10 )   180604 - 180604   2018.10   （ ISSN:2054-5703 ）

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：The Royal Society  

    DOI： 10.1098/rsos.180604

    Scopus

  • Flight feather development: its early specialization during embryogenesis.

    Zoological Letters   2018

  • Flight feather development: Its early specialization during embryogenesis Reviewed

    Kondo, M., Sekine, T., Miyakoshi, T., Kitajima, K., Egawa, S., Seki, R., Abe, G., Tamura, K.

    Zoological Letters   4 ( 1 )   2018   （ ISSN:2056-306X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40851-017-0085-4

    Scopus

  • Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods Reviewed

    Yoshiyuki Matsubara, Tatsuya Hirasawa, Shiro Egawa, Ayumi Hattori, Takaya Suganuma, Yuhei Kohara, Tatsuya Nagai, Koji Tamura, Shigeru Kuratani, Atsushi Kuroiwa, Takayuki Suzuki

    Nature Ecology and Evolution   1 ( 9 )   1392 - 1399   2017.9   （ ISSN:2397-334X ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Publishing Group  

    Elucidating how body parts from different primordia are integrated during development is essential for understanding the nature of morphological evolution. In tetrapod evolution, while the position of the hindlimb has diversified along with the vertebral formula, the mechanism responsible for this coordination has not been well understood. However, this synchronization suggests the presence of an evolutionarily conserved developmental mechanism that coordinates the positioning of the hindlimb skeleton derived from the lateral plate mesoderm with that of the sacral vertebrae derived from the somites. Here we show that GDF11 secreted from the posterior axial mesoderm is a key factor in the integration of sacral vertebrae and hindlimb positioning by inducing Hox gene expression in two different primordia. Manipulating the onset of GDF11 activity altered the position of the hindlimb in chicken embryos, indicating that the onset of Gdf11 expression is responsible for the coordinated positioning of the sacral vertebrae and hindlimbs. Through comparative analysis with other vertebrate embryos, we also show that each tetrapod species has a unique onset timing of Gdf11 expression, which is tightly correlated with the anteroposterior levels of the hindlimb bud. We conclude that the evolutionary diversity of hindlimb positioning resulted from heterochronic shifts in Gdf11 expression, which led to coordinated shifts in the sacral-hindlimb unit along the anteroposterior axis.

    DOI： 10.1038/s41559-017-0247-y

    Scopus

    PubMed

  • Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features Reviewed

    Seki, R., Li, C., Fang, Q., Hayashi, S., Egawa, S., Hu, J., Xu, L., Pan, H., Kondo, M., Sato, T., Matsubara, H., Kamiyama, N., Kitajima, K., Saito, D., Liu, Y., Gilbert, M.T.P., Zhou, Q., Xu, X., Shiroishi, T., Irie, N., Tamura, K., and Zhang, G.

    Nature Communications   8 ( 1 )   2017   （ ISSN:20411723 eISSN:2041-1723 ）

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (>99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes.

    DOI： 10.1038/ncomms14229

    Other Link： https://www.nature.com/articles/ncomms14229

  • Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 enables the evolutionary diversification of hindlimb positioning in tetrapods

    Nature Ecology & Evolution.   2017

  • Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features

    Nature Communications   2017

  • Evidence for an amphibian sixth digit Reviewed

    Hayashi, S., Kobayashi, T., Yano, T., Kamiyama, N., Egawa, S., Seki, R., Takizawa, K., Okabe, M., Yokoyama, H. and Tamura, K.

    Zoological Letters   2015

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    Publishing type：Research paper (scientific journal)  

  • Evidence for an amphibian sixth digit

    Zoological Letters   2015

  • Growth and differentiation of a long bone in limb development, repair and regeneration Reviewed

    Shiro EGAWA

    Development Growth and Differentiation   56 ( 5 )   410 - 424   2014   （ ISSN:0012-1592 ）

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Developmental Biologists ; 1969-  

    CiNii Books

    Other Link： http://search.jamas.or.jp/link/ui/2015062206

  • Fins and limbs: Emergence of morphological differences

    Yano, T., Matsubara, H., Egawa, S., Onodera, K., Tamura, K.

    New Principles in Developmental Processes   9784431546344   2014   （ ISBN:4431546332, 9784431546344, 9784431546337 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/978-4-431-54634-4_22

    Scopus

  • Growth and differentiation of a long bone in limb development, repair and regeneration

    Development Growth and Differentiation   2014

  • 四肢形態の多様性を支える発生メカニズム

    生物の科学 遺伝   2013

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Books

  • 第1章 鳥とワニの研究で恐竜の胎児が見えてくる？

    江川史朗

    2022.11 

  • Chapter 21 Fins and Limbs: emergence of morphological difference

    Yano, T, Matsubara, H, Egawa, S, Onodera, K, Tamura, K

    2014.1 

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  • Fins and Limbs: emergence of morphological differences

    2014 

  • 四肢形態の多様性を支える発生メカニズム.

    矢野十織, 松原遼, 江川史朗, 小野寺孝興, 田村宏治

    2013.3 

Presentations

  • High-density neural recording reveals populational dynamics of the cervical spinal cord in rats performing target-reaching task

    Egawa. S., Kosugi, A., Maeda, K., Seki, K.

    OIST workshop: Sensorimotor circuits for limb control  2024.3 

  • On the Morphogenetic Historiography of the Archosaur Femur.

    Egawa, S, Botelho, J, Bhullar, B.A.S

    International Congress of Vertebrate Morphology12  2019.7 

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    Language：English   Presentation type：Oral presentation (general)  

  • The dinosaurian femoral head experienced a cryptic evolutionary shift in morphogenetic process.

    Egawa. S., Bishop, P.J., Pintore, R., Tsai, H.T., Griffin, C.T., Botelho, J.F., Smith-Paredes, D., Nesbitt, S.J., Hutchinson, J.R., Bhullar, B.A.S.

    The 2nd AsiaEvo conference  2021.8 

  • The evolution of acetabular morphogenesis on the line to extant birds

    Egawa, S., Abe, G., Tamura, K.

    the 50th Annual Meeting of the Japanese Society of Developmental Biologists  2017.5 

  • The evolutionary change of morphogenesis of dinosaur-type femoral head

    Egawa. S., Bishop, P.J., Pintore, R., Griffin, C.T., Tsai, H.T., Botelho, J.F., Smith-Paredes, D., Kuratani, S., Norell, M.A., Nesbitt, S.J., Hutchinson, J.R., Bhullar, B.A.S.

    SICB 2021  2021.1 

  • The inference about transition of hip joint morphogenesis in the dinosaurian lineage.

    Egawa, S, Abe G, Tamura K

    Avian Model Systems 9: A New Integrative Platform  2016.3 

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    Language：English   Presentation type：Oral presentation (general)  

  • The reconstruction of the evolutionary history of femoral morphogenesis in archosaur

    Egawa, S, Botelho, J, Bhullar, B.A.S

    第52回日本発生生物学会年会  2019.5 

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    Presentation type：Oral presentation (general)  

  • 主竜類の股関節 -発生と機能の交差点- Invited

    江川史朗

    日本古生物学会 第171回例会  2022.2 

  • 恐竜の股関節における発生システム浮動

    江川史朗

    第7回生態進化発生コロキウム  2019.12 

  • 恐竜の股関節の形態形成機構の推論

    江川史朗, 横山仁, 田村宏治

    日本動物学会第85回仙台大会  2014.9 

  • 恐竜の股関節形態の形成機構の推論

    江川史朗, 阿部玄武, 田村宏治

    日本動物学会第86回大会  2015.9 

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    Presentation type：Oral presentation (general)  

  • 恐竜は卵の中にいる ～発生生物学的観点からの恐竜研究～ Invited

    江川史朗

    東北大学学際科学フロンティア研究所 フロンティア生命科学セミナー 生命科学の最前線(フロンティア) ～独自の視点から挑む多彩な生命現象を体感せよ～  2017.6 

  • 恐竜型股関節の獲得過程の復元：実験発生学的観点から

    江川史朗、阿部玄武、齋藤大介、田村宏治

    日本進化学会大19回大会  2017.8 

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    Presentation type：Oral presentation (general)  

  • 恐竜型股関節の発生学的獲得メカニズムについて

    江川史朗

    日本発生生物学会夏季シンポジウム  2017.9 

  • 有機的ボディプランの進化史叙述に向けて：恐竜の大腿を例に Invited

    江川史朗

    第15回生物学基礎論研究会  2022.8 

  • 生活史サイクルの中の”因果性”についての検討 Invited

    江川史朗

    第16回生物学基礎論研究会  2023.3 

  • 絶滅動物の発生様式の推論

    江川史朗

    第11回生物学基礎論研究会  2017.9 

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    Presentation type：Oral presentation (general)  

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MISC

  • 比較法で神経生理学を解釈する

    江川 史朗

    第12回 Tokyo Vertebrate Morphology Meeting   2024.9

  • 巧緻運動中ラット頚髄からの⾼密度記録

    江川 史朗, 小杉 亮人, 前田 和孝, 関 和彦

    第18回 Motor Control研究会   2024.8

  • Neuropixels recording in the spinal cord of behaving rats

    Egawa. S., Kosugi, A., Maeda, K., Seki, K.

    Neuroscience 2023   2023.11

  • 随意運動中ラット頚髄からの多チャンネル記録

    江川 史朗, 前田 和孝, 小杉 亮人, 関 和彦

    第17回 Motor Control研究会   2023.8

  • 神経生理学に比較形態学的アプローチで迫る

    江川 史朗, 前田 和孝, 小杉 亮人, 関 和彦

    第11回 Tokyo Vertebrate Morphology Meeting   2023.7

  • ワニと恐竜の大腿骨頭は相同だが、恐竜と鳥の大腿骨頭は相同ではない

    江川史朗, Joao F. Botelho, 倉谷滋, John R. Hutchinson, Bhart-Anjan S. Bhullar

    日本古生物学会 2020年例会   2020.2

  • On a mechanism for the acquisition of dinosaur type hip joint.

    Egawa, S, Abe, G, Saito, D, Tamura, K

    第46回内藤コンファレンス -生物進化の仕組みと多様性-   2018.10

  • 動物の胚を用いた寛骨臼形態形成の基礎研究：先天性疾患・進化への洞察

    江川史朗

    第44回日本股関節学会   2017.10

  • 恐竜はいかにして恐竜型の股関節を獲得したのか？

    江川史朗, 阿部玄武, 齋藤大介, 田村宏治

    第7回 Tokyo Vertebrate Morphology Meeting   2017.7

  • 恐竜はいかにして恐竜型の股関節を獲得したのか？

    江川史朗

    第10回Evo-Devo青年の会   2017.6

  • 実験発生学的観点からの恐竜研究

    江川史朗, 阿部玄武, 田村宏治

    日本古生物学会第166回例会   2017.1

  • Inference for the acquisition of a dinosaur-type acetabulum.

    Egawa, S, Abe G, Tamura K

    Joint meeting of the 22nd ICZ & the 87th meeting of the ZSJ   2016.11

  • 恐竜の系統における股関節の形態形成機構の進化

    江川史朗

    第9回Evo-Devo青年の会   2016.6

  • 恐竜の股関節形態形成機構の推論

    江川史朗, 阿部玄武, 田村宏治

    日本進化学会第17回東京大会   2015.8

  • 恐竜の股関節形態形成機構の推論

    江川史朗, 阿部玄武, 田村宏治

    第5回 Tokyo Vertebrate Morphology Meeting   2015.8

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Professional Memberships

  • Motor Control研究会

  • 北米神経科学学会

  • 日本動物学会

  • 日本古生物学会

  • 日本家禽学会

  • 日本発生生物学会

  • 日本進化学会

  • 鶏病研究会

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Committee Memberships

  • Evo-Devo 青年の会   幹事  

    2017.6 - 2019.9   

Other

  • Poultry Industry Technician Examination (Animal Hygiene), passed

    2025.2