Faculty Profiles - EGAWA SHIRO

写真a

EGAWA SHIRO

Organization

Faculty of Agriculture Department of Bioresource Sciences Assistant Professor
Graduate School of Bioresource and Bioenvironmental Sciences Department of Agro-environmental Sciences（Concurrent）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioresource Sciences（Concurrent）
School of Agriculture Department of Bioresource and Bioenvironment（Concurrent）

Research Areas

Life Science / Animal life science
Life Science / Animal physiological chemistry, physiology and behavioral biology
Life Science / Laboratory animal science
Life Science / Morphology and anatomical structure
Life Science / Developmental biology
Life Science / Anatomy
Life Science / Evolutionary biology

▼display all

Research History

Kyushu University Faculty of Agriculture Assistant Professor

2025.4 - Present

　 More details

Country：Japan
National Center of Neurolgy and Psychiatry National Institute of Neuroscience 科研費研究員/リサーチフェロー

2022.5 - 2025.3

　 More details

Country：Japan

Notes：Department of Neurophysiology
RIKEN Center for Biosystems Dynamics Research Special Postdoctoral Researcher

2019.5 - 2022.4
Yale University Peabody Museum of Natural History Postdoctorral Associate

2018.11 - 2019.4

　 More details

Country：United States
Yale University Peabody Museum of Natural History visiting researcher

2018.7 - 2018.10

　 More details

Country：United States
Tohoku University Graduate School of Life Sciences postdoctoral fellow

2018.4 - 2018.10
Japan Society for the Promotion of Science Doctoral Research Fellow (DC1)

2015.4 - 2018.3

▼display all

Education

Tohoku University Graduate School of Life Sciences

2014.10 - 2018.4
Tohoku University Graduate School of Life Sciences

2012.10 - 2014.9
Waseda University School of Advanced Science and Engineering

2008.4 - 2012.3

Research Interests・Research Keywords

Research theme：運動器

Keyword：運動器

Research period： 2025
Research theme：動物生体機構

Keyword：動物生体機構

Research period： 2025
Research theme：家禽

Keyword：家禽

Research period： 2025
Research theme： dinosaurs

Keyword： dinosaurs

Research period： 2025
Research theme：比較解剖学

Keyword：比較解剖学

Research period： 2025
Research theme：発生生物学

Keyword：発生生物学

Research period： 2025
Research theme： neurophysiology

Keyword： neurophysiology

Research period： 2025
Research theme： evo-devo

Keyword： evo-devo

Research period： 2025
Research theme： motor control

Keyword： motor control

Research period： 2025

Awards

基礎特別科学研究員成果発表会優秀賞 (生物学部門)

2022.1 理化学研究所
Award of Aoba science promotion association

2018.3 Tohoku University
Excellent Poster Award in 166th meeting

2017.1 Palaeontological Society of Japan

受賞対象発表演題「実験発生学的観点からの恐竜研究」

Papers

Author Correction: The developing bird pelvis passes through ancestral dinosaurian conditions (Nature, (2022), 608, 7922, (346-352), 10.1038/s41586-022-04982-w)

Griffin, C.T., Botelho, J.F., Hanson, M., Fabbri, M., Smith-Paredes, D., Carney, R.M., Norell, M.A., Egawa, S., Gatesy, S.M., Rowe, T.B., Elsey, R.M., Nesbitt, S.J., Bhullar, B.-A.S.

Nature 623 ( 7989 ) E19 2023 （ ISSN:1476-4687 ）

　More details

Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41586-023-06765-3

Scopus
The dinosaurian femoral head experienced a morphogenetic shift from torsion to growth along the avian stem Reviewed

Egawa, S., Griffin, C.T., Bishop, P.J., Pintore, R., Tsai, H.P., Botelho, J.F., Smith-Paredes, D., Kuratani, S., Norell, M.A., Nesbitt, S.J., Hutchinson, J.R., Bhullar, B.-A.S.

Proceedings of the Royal Society B: Biological Sciences 289 ( 1984 ) 2022.10 （ ISSN:1471-2954 ）

　More details

Authorship：Lead author,　Corresponding author Publishing type：Research paper (scientific journal)

DOI： 10.1098/rspb.2022.0740

Scopus
The developing bird pelvis passes through ancestral dinosaurian conditions Reviewed

Christopher T. Griffin, João F. Botelho, Michael Hanson, Matteo Fabbri, Daniel Smith-Paredes, Ryan M. Carney, Mark A. Norell, Shiro Egawa, Stephen M. Gatesy, Timothy B. Rowe, Ruth M. Elsey, Sterling J. Nesbitt, Bhart-Anjan S. Bhullar

Nature 608 ( 7922 ) 346 - 352 2022.7 （ ISSN:0028-0836 eISSN:1476-4687 ）

　More details

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1038/s41586-022-04982-w

Other Link： https://www.nature.com/articles/s41586-022-04982-w
Homeobox code model of heterodont tooth in mammals revised Reviewed

Wakamatsu, Y., Egawa, S., Terashita, Y., Kawasaki, H., Tamura, K., Suzuki, K.

Scientific Reports 9 ( 1 ) 2019.9 （ ISSN:2045-2322 ）

　More details

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media {LLC}

DOI： 10.1038/s41598-019-49116-x

Scopus
Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum Reviewed

Egawa, S., Saito, D., Abe, G., Tamura, K.

Royal Society Open Science 5 ( 10 ) 180604 - 180604 2018.10 （ ISSN:2054-5703 ）

　More details

Authorship：Lead author,　Corresponding author Publishing type：Research paper (scientific journal) Publisher：The Royal Society

DOI： 10.1098/rsos.180604

Scopus
Flight feather development: its early specialization during embryogenesis.

Zoological Letters 2018
Flight feather development: Its early specialization during embryogenesis Reviewed

Kondo, M., Sekine, T., Miyakoshi, T., Kitajima, K., Egawa, S., Seki, R., Abe, G., Tamura, K.

Zoological Letters 4 ( 1 ) 2018 （ ISSN:2056-306X ）

　More details

Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40851-017-0085-4

Scopus
Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods Reviewed

Yoshiyuki Matsubara, Tatsuya Hirasawa, Shiro Egawa, Ayumi Hattori, Takaya Suganuma, Yuhei Kohara, Tatsuya Nagai, Koji Tamura, Shigeru Kuratani, Atsushi Kuroiwa, Takayuki Suzuki

Nature Ecology and Evolution 1 ( 9 ) 1392 - 1399 2017.9 （ ISSN:2397-334X ）

　More details

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Publishing Group

Elucidating how body parts from different primordia are integrated during development is essential for understanding the nature of morphological evolution. In tetrapod evolution, while the position of the hindlimb has diversified along with the vertebral formula, the mechanism responsible for this coordination has not been well understood. However, this synchronization suggests the presence of an evolutionarily conserved developmental mechanism that coordinates the positioning of the hindlimb skeleton derived from the lateral plate mesoderm with that of the sacral vertebrae derived from the somites. Here we show that GDF11 secreted from the posterior axial mesoderm is a key factor in the integration of sacral vertebrae and hindlimb positioning by inducing Hox gene expression in two different primordia. Manipulating the onset of GDF11 activity altered the position of the hindlimb in chicken embryos, indicating that the onset of Gdf11 expression is responsible for the coordinated positioning of the sacral vertebrae and hindlimbs. Through comparative analysis with other vertebrate embryos, we also show that each tetrapod species has a unique onset timing of Gdf11 expression, which is tightly correlated with the anteroposterior levels of the hindlimb bud. We conclude that the evolutionary diversity of hindlimb positioning resulted from heterochronic shifts in Gdf11 expression, which led to coordinated shifts in the sacral-hindlimb unit along the anteroposterior axis.

DOI： 10.1038/s41559-017-0247-y

Scopus

PubMed
Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features Reviewed

Seki, R., Li, C., Fang, Q., Hayashi, S., Egawa, S., Hu, J., Xu, L., Pan, H., Kondo, M., Sato, T., Matsubara, H., Kamiyama, N., Kitajima, K., Saito, D., Liu, Y., Gilbert, M.T.P., Zhou, Q., Xu, X., Shiroishi, T., Irie, N., Tamura, K., and Zhang, G.

Nature Communications 8 ( 1 ) 2017 （ ISSN:20411723 eISSN:2041-1723 ）

　More details

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (>99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes.

DOI： 10.1038/ncomms14229

Other Link： https://www.nature.com/articles/ncomms14229
Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 enables the evolutionary diversification of hindlimb positioning in tetrapods

Nature Ecology & Evolution. 2017
Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features

Nature Communications 2017
Evidence for an amphibian sixth digit Reviewed

Hayashi, S., Kobayashi, T., Yano, T., Kamiyama, N., Egawa, S., Seki, R., Takizawa, K., Okabe, M., Yokoyama, H. and Tamura, K.

Zoological Letters 2015

　More details

Publishing type：Research paper (scientific journal)
Evidence for an amphibian sixth digit

Zoological Letters 2015
Growth and differentiation of a long bone in limb development, repair and regeneration Reviewed

Shiro EGAWA

Development Growth and Differentiation 56 ( 5 ) 410 - 424 2014 （ ISSN:0012-1592 ）

　More details

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Developmental Biologists ; 1969-

CiNii Books

Other Link： http://search.jamas.or.jp/link/ui/2015062206
Fins and limbs: Emergence of morphological differences

Yano, T., Matsubara, H., Egawa, S., Onodera, K., Tamura, K.

New Principles in Developmental Processes 9784431546344 2014 （ ISBN:4431546332, 9784431546344, 9784431546337 ）

　More details

Publishing type：Research paper (scientific journal)

DOI： 10.1007/978-4-431-54634-4_22

Scopus
Growth and differentiation of a long bone in limb development, repair and regeneration

Development Growth and Differentiation 2014
四肢形態の多様性を支える発生メカニズム

生物の科学遺伝 2013

▼display all

Books

第1章鳥とワニの研究で恐竜の胎児が見えてくる？

江川史朗

2022.11
Chapter 21 Fins and Limbs: emergence of morphological difference

Yano, T, Matsubara, H, Egawa, S, Onodera, K, Tamura, K

2014.1

　More details

DOI： 10.1007/978-4-431-54634-4_22
Fins and Limbs: emergence of morphological differences

2014
四肢形態の多様性を支える発生メカニズム.

矢野十織, 松原遼, 江川史朗, 小野寺孝興, 田村宏治

2013.3

Presentations

High-density neural recording reveals populational dynamics of the cervical spinal cord in rats performing target-reaching task

Egawa. S., Kosugi, A., Maeda, K., Seki, K.

OIST workshop: Sensorimotor circuits for limb control 2024.3
On the Morphogenetic Historiography of the Archosaur Femur.

Egawa, S, Botelho, J, Bhullar, B.A.S

International Congress of Vertebrate Morphology12 2019.7

　More details

Language：English Presentation type：Oral presentation (general)
The dinosaurian femoral head experienced a cryptic evolutionary shift in morphogenetic process.

Egawa. S., Bishop, P.J., Pintore, R., Tsai, H.T., Griffin, C.T., Botelho, J.F., Smith-Paredes, D., Nesbitt, S.J., Hutchinson, J.R., Bhullar, B.A.S.

The 2nd AsiaEvo conference 2021.8
The evolution of acetabular morphogenesis on the line to extant birds

Egawa, S., Abe, G., Tamura, K.

the 50th Annual Meeting of the Japanese Society of Developmental Biologists 2017.5
The evolutionary change of morphogenesis of dinosaur-type femoral head

Egawa. S., Bishop, P.J., Pintore, R., Griffin, C.T., Tsai, H.T., Botelho, J.F., Smith-Paredes, D., Kuratani, S., Norell, M.A., Nesbitt, S.J., Hutchinson, J.R., Bhullar, B.A.S.

SICB 2021 2021.1
The inference about transition of hip joint morphogenesis in the dinosaurian lineage.

Egawa, S, Abe G, Tamura K

Avian Model Systems 9: A New Integrative Platform 2016.3

　More details

Language：English Presentation type：Oral presentation (general)
The reconstruction of the evolutionary history of femoral morphogenesis in archosaur

Egawa, S, Botelho, J, Bhullar, B.A.S

第52回日本発生生物学会年会 2019.5

　More details

Presentation type：Oral presentation (general)
主竜類の股関節 -発生と機能の交差点- Invited

江川史朗

日本古生物学会第171回例会 2022.2
恐竜の股関節における発生システム浮動

江川史朗

第7回生態進化発生コロキウム 2019.12
恐竜の股関節の形態形成機構の推論

江川史朗, 横山仁, 田村宏治

日本動物学会第85回仙台大会 2014.9
恐竜の股関節形態の形成機構の推論

江川史朗, 阿部玄武, 田村宏治

日本動物学会第86回大会 2015.9

　More details

Presentation type：Oral presentation (general)
恐竜は卵の中にいる～発生生物学的観点からの恐竜研究～ Invited

江川史朗

東北大学学際科学フロンティア研究所フロンティア生命科学セミナー生命科学の最前線(フロンティア) ～独自の視点から挑む多彩な生命現象を体感せよ～ 2017.6
恐竜型股関節の獲得過程の復元：実験発生学的観点から

江川史朗、阿部玄武、齋藤大介、田村宏治

日本進化学会大19回大会 2017.8

　More details

Presentation type：Oral presentation (general)
恐竜型股関節の発生学的獲得メカニズムについて

江川史朗

日本発生生物学会夏季シンポジウム 2017.9
有機的ボディプランの進化史叙述に向けて：恐竜の大腿を例に Invited

江川史朗

第15回生物学基礎論研究会 2022.8
生活史サイクルの中の”因果性”についての検討 Invited

江川史朗

第16回生物学基礎論研究会 2023.3
絶滅動物の発生様式の推論

江川史朗

第11回生物学基礎論研究会 2017.9

　More details

Presentation type：Oral presentation (general)

▼display all

MISC

比較法で神経生理学を解釈する

江川史朗

第12回 Tokyo Vertebrate Morphology Meeting 2024.9
巧緻運動中ラット頚髄からの⾼密度記録

江川史朗, 小杉亮人, 前田和孝, 関和彦

第18回 Motor Control研究会 2024.8
Neuropixels recording in the spinal cord of behaving rats

Egawa. S., Kosugi, A., Maeda, K., Seki, K.

Neuroscience 2023 2023.11
随意運動中ラット頚髄からの多チャンネル記録

江川史朗, 前田和孝, 小杉亮人, 関和彦

第17回 Motor Control研究会 2023.8
神経生理学に比較形態学的アプローチで迫る

江川史朗, 前田和孝, 小杉亮人, 関和彦

第11回 Tokyo Vertebrate Morphology Meeting 2023.7
ワニと恐竜の大腿骨頭は相同だが、恐竜と鳥の大腿骨頭は相同ではない

江川史朗, Joao F. Botelho, 倉谷滋, John R. Hutchinson, Bhart-Anjan S. Bhullar

日本古生物学会 2020年例会 2020.2
On a mechanism for the acquisition of dinosaur type hip joint.

Egawa, S, Abe, G, Saito, D, Tamura, K

第46回内藤コンファレンス -生物進化の仕組みと多様性- 2018.10
動物の胚を用いた寛骨臼形態形成の基礎研究：先天性疾患・進化への洞察

江川史朗

第44回日本股関節学会 2017.10
恐竜はいかにして恐竜型の股関節を獲得したのか？

江川史朗, 阿部玄武, 齋藤大介, 田村宏治

第7回 Tokyo Vertebrate Morphology Meeting 2017.7
恐竜はいかにして恐竜型の股関節を獲得したのか？

江川史朗

第10回Evo-Devo青年の会 2017.6
実験発生学的観点からの恐竜研究

江川史朗, 阿部玄武, 田村宏治

日本古生物学会第166回例会 2017.1
Inference for the acquisition of a dinosaur-type acetabulum.

Egawa, S, Abe G, Tamura K

Joint meeting of the 22nd ICZ & the 87th meeting of the ZSJ 2016.11
恐竜の系統における股関節の形態形成機構の進化

江川史朗

第9回Evo-Devo青年の会 2016.6
恐竜の股関節形態形成機構の推論

江川史朗, 阿部玄武, 田村宏治

日本進化学会第17回東京大会 2015.8
恐竜の股関節形態形成機構の推論

江川史朗, 阿部玄武, 田村宏治

第5回 Tokyo Vertebrate Morphology Meeting 2015.8

▼display all

Professional Memberships

Motor Control研究会
北米神経科学学会
日本動物学会
日本古生物学会
日本家禽学会
日本発生生物学会
日本進化学会
鶏病研究会

▼display all

Committee Memberships

Evo-Devo 青年の会幹事

2017.6 - 2019.9

Other

Poultry Industry Technician Examination (Animal Hygiene), passed

2025.2

Information

Information

Research Areas

Research Areas

Research History

Research History

Education

Education

Research Interests・Research Keywords

Research Interests・Research Keywords

Awards

Awards

Papers

Papers

Books

Books

Presentations

Presentations

MISC

MISC

Professional Memberships

Professional Memberships

Committee Memberships

Committee Memberships

Other

Other