https://kyushu-u.elsevierpure.com/en/persons/shigehiro-ohdo
　Reseacher Profiling Tool　Kyushu University Pure

http://yakuzai.phar.kyushu-u.ac.jp
The study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs. .