Kyushu University Academic Staff Educational and Research Activities Database
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Takanari Kitazono Last modified date:2023.09.28

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 Reseacher Profiling Tool Kyushu University Pure
Division of Cerebrovascular Disease .
Academic Degree
Field of Specialization
cerebrovascular disorder
Outline Activities
We have established multi center registry systems of patients with stroke, diabetes, kidney disease, hypertension, and gastrointestinal diseases and are analyzing the data to clarify the pathogenesis, clinical course, outcomes and prognosis of these diseases. We are also doing basic research to investigate the detailed pathphysiological mechanisms.
Research Interests
  • An epidemiological study of acute stroke patients, the Fukuoka Stroke Registry (FSR)
    keyword : stroke, cohort study, epidemiology, database
    2007.06We are doing multi-center registration study in which clinical information during acute phase and long-term prognosis of acute stroke patients are collected. In teh FSR, genome and plasma are also collected and stored for the future analysis. We will find out new evidences about stroke in Japan..
  • Genomics of brain infarction
    keyword : brain infarction, genomics, SNP
    2005.04To find genes susceptible to brain infarction, we are doing a large-scale case-control association study..
  • Molecular biology of CNS pericytes
    keyword : cerebral microcirculation, pericyte
    2004.04We are investigating the role of CNS pericytes in the regulation of cerebral microcirculation, superoxide production, and angiogenesis..
  • Study on cerebrovascular responses
    keyword : responses of cerebral arteries, nitric oxide, potassium channels, hypertension
    1991.09I have been investigating the mechanisms of cerebrovascular responses both in vivo and in vitro. I have shown, using a cranial window technique, the important role of potassium channels in the dilator responses of rat basilar artery in vivo. Moreover, I have examined the vascular responses during chronic hypertension and found that the activities of both nitric oxide and potassium channels are impaired in the basilar artery during chronic hypertension, which may contribute to the development of cerebrovascular lesions in hypertensice subjects. Recently, I am studying the molecular identity of NADPH oxidase in the endothelial and smooth mauscle cells and found that NOX4 is the major catalytic subunit of NADPH oxidase in the endothelial cells..
Current and Past Project
  • Using our original multi-center stroke data base (Fukuoka Stroke Registry; FSR), we have been investigating the clinical features of stroke patients in Japan.
  • I have been investigating the molecular identity and the functional role of the NAD(P)H oxidase in the vascular endothelial and smooth muscle cells.
  • Using cranial window technique and other pharmacological techniques, I have been investigating the regulation mechanisms of cerebral circulation. I focus on the changes of cerebrovascular responses during chronic hypertension.
Academic Activities
1. Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T., Pathological roles of NADPH oxidase-nox family proteins in the vascular system., 2011.07.
2. Kamouchi M, Ago T, Kitazono T., Brain pericytes: emerging concepts and functional roles in brain homeostasis., Cell Mol Neurobiol, 31: 175-193, 2011.03.
1. Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke., Stroke, 48, 11, 3049-3056, 48(11):3049-3056, 2017.11.
2. Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T, Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study., Circulation, 136, 6, 516-525, 136(6):516-525, 2017.08.
3. Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T, Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons., Stroke, 48, 8, 2222-2230, 48(8):2222-2230, 2017.08.
4. Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, Ohtsubo T, Matsumura K, Kitazono T, Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension., Hypertension, 69, 1, 143-153, 2017.01.
5. Matsuo R, Michikawa T, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke., Stroke, 47, 12, 3032-3034, 2016.12.
6. Eriguchi M, Tsuruya K, Haruyama N, Yamada S, Tanaka S, Suehiro T, Noguchi H, Masutani K, Torisu K, Kitazono T, Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease., Kidney Int, 87, 116-127, 2015.01.
7. Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators, High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry., Hypertension, 63, 54-60, 2014.01.
8. Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators, Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry., Stroke, 44, 3239-3242, 2013.11.
9. Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y, Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009)., Circulation, 128, 1198-1205, 2013.09.
10. Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y, Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study., Kidey Int, 84, 373-380, 2013.08.
11. Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T, Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca2+ oscillation in central nervous system pericytes., Arterioscler Thromb Vasc Biol, 32, 2670-2677, 2012.11.
12. Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T, for the FSR Investigators, Proteinuria and clinical outcomes after ischemic stroke., Neurology, 78, 1909-1915, 2012.06.
13. Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A, Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain., Nat Med, 18, 911-918, 2012.06.
14. Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T., PDGF receptor β signaling in pericytes following ischemic brain injury., Cur Neurovasc Res, 9, 1-9, 2012.02.
15. Yamada S, Taniguchi M, Tokumoto M, Toyonaga J, Fujisaki K, Suehiro T, Noguchi H, Iida M, Tsuruya K, Kitazono T., The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenisis of vascular calcification in chronic kidney disease., J Bone Miner Res, 27, 2, 474-485, 2012.02.
16. Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; for the FSR investigators., Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry., Stroke, 42, 2788-2794, 2011.10.
17. Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitaozono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M., Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke., Hum Mol Genet, 19, 6, 1137-1146, 2010.03.
18. Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M, Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes, American Journal of Physiology, 294: H1700-H1707, 2008.04.
19. Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohada Y, Ibayashi S, Iida M, NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama Study, European Journal of Neurology, 14: 12-16, 2007.10.
20. Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y., A nonsynonymous SNP IN PRKCH (protein kinase Cη) increases the risk of cerebral infarction., Nat Genet, 39, 2, 212-217, 2007.02.
21. Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M., NAD(P)H oxidases in rat basilar arterial endothelial cells., Stroke, 10.1161/01.STR.0000163111.05825.0b, 36, 5, 1040-1046, 2005.05.
22. Ago, T., Kitazono, T., Ooboshi, H., Matsuo, R., Takada, J., Wakisaka, M., Ibayashi, S., Iida, M, NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase., Circuration, 10.1161/01.CIR.0000105680.92873.70, 109, 2, 227-233, 109: 227-233, 2004.01.
23. Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M., Ibayashi, S., Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo., Journal of Hypertension, 10.1097/00004872-200205000-00022, 20, 5, 879-884, 20: 879-884, 2002.01.
24. Wakisaka, M., Kitazono, T., Kato, M., Nakamura, U., Yoshioka, M., Uchizono, Y., Yoshinari, M., Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation., Circulation Research, 10.1161/hh1101.091265, 88, 11, 1183-1188, 88 1183-1188, 2001.01.
25. Kitayama, J., Kitazono, T., Ibayashi, S., Nagao, T., Wakisaka, M., Watanabe, Y., Fujishima, M., Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery in vivo., Stroke, 31, 10, 2487-2492, 31: 2487-2493, 2000.01.
26. Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Kagiyama, T., Fujishima, M., Role of tyrosine kinase in dilator responses of the basilar artery in vivo., Hypertension, 31, 3, 861-865, 31: 861-865, 1998.01.
27. Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M., Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-dependent K+ channels., Circulation Research, 76: 1057-1062, 1995.01.
28. Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D., Relaxation of the aorta during hypertension is impaired in chronically hypertensive rats., Hypertension, 25: 735-738, 1995.01.
29. Kitazono, T., Heistad, D.D., Faraci, F.M., Enhanced responses of the basilar artery to activation of endothelin B receptors in stroke-prone spontaneously hypertensive rats., Hypertension, 25: 490-494, 1995.01.
30. Kitazono, T., Padgett, R.C., Armstrong, M.L., Tompkins, P.K., Heistad, D.D., Evidence that angiotensin II is present in human monocytes., Circulation, 91: 1129-1134, 1995.01.
31. Taguchi H, Heistad DD, Kitazono T, Faraci FM, ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia., Circulation Research, 74: 1005-1008, 1994.01.
32. Kitazono, T., Heistad, D.D., Faraci, F.M., ATP-sensitive potassium channels in the basilar artery during chronic hypertension., Hypertension, 22: 677-681, 1993.01.
33. Kitazono, T., Heistad, D.D., Faraci, F.M., Role of ATP-sensitive K+ channels in CGRP-induced dilatation of the basilar artery in vivo., American Journal of Physiology, 265: H581-H585, 1993.01.
34. Kitazono, T., Faraci, F.M., Heistad, D.D., Effect of norepinephrine on rat basilar artery in vivo., American Journal of Physiology, 264: H178-H182, 1993.01.
35. Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S., Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition., Biochemical and Biophysical Research Communication, 10.1016/S0006-291X(88)80427-3, 152, 3, 1304-1309, 152: 1304-1309, 1988.01.
1. Hypertension and chronic kidney disease (CKD) in acute stroke patients; the Fukuoka Stroke Registry.
2. Molecular epidemiology of cerebrovascular disease; The Hisayama Study and the Fukuoka Stroke Registry (FSR).
Educational Activities
[Educational activities]
Lecture about cerebrovascular disorders