Kyushu University [Naotaka YAMADA (Assistant Professor) Faculty of Agriculture, Department of Bioscience and Biotechnology]

＜Research＞
Development of new plant growth regurators and insect growth regulator
１．Synthesis of novel freezing- tolerance inducing agents for Chlorella vulgaris and research on its mode of action.
２．Development of new carotenoid biosynthesis inhibitors.
３．Search of New　glutathione S-transferase　with insecticides metabolic activity on　Bombyx mori　　

＜Education＞
　lecture:organic chemistry, Natural products chemistry

Research

Research Interests

Design, Synthesis and Biological Activity of Novel Anti-Juvenile Hormone Agents
keyword : Juvenile Hormone, Insect growth regulator, organic synthesis
2006.04～2012.03.
Isolation and identification of sucking deterrent against green rice leafhopper and brown planthopper
in rice using Near Isogenic Lines.
keyword : rice ・green rice leafhopper ・sucking deterrent ・Near Isogenic Lines
2006.04～2011.03.
Ｒsearch of new bleaching compounds in targeting carotenoid biosynthesis in plant.
keyword : bleaching, carotenoid, phetoene, zeta-carotene
1997.12～2017.03.
Physiological Analysis of 8-Nitro-cycli-GMP in Plant or Incet
keyword : 8-Nitro-cycli-GMP
2012.04～2017.03.
Study on　insecticide metabolism by Incect　glutathione transferases (GST) 　
keyword : glutathione transferase，insecticide，
2013.04～2017.03.

Academic Activities

Papers

Show All Papers >>

1.	Sumio Iwai, Sho Ogata, Naotaka Yamada, Michio Onjo, Kintake Sonoike, Ken ichiro Shimazaki, Guard cell photosynthesis is crucial in abscisic acid-induced stomatal closure, Plant Direct, 10.1002/pld3.137, 3, 5, e00137, 2019.05, Reactive oxygen species (ROS) are ubiquitous signaling molecules involved in diverse physiological processes, including stomatal closure. Photosynthetic electron transport (PET) is the main source of ROS generation in plants, but whether it functions in guard cell signaling remains unclear. Here, we assessed whether PET functions in abscisic acid (ABA) signaling in guard cells. ABA-elicited ROS were localized to guard cell chloroplasts in Arabidopsis thaliana, Commelina benghalensis, and Vicia faba in the light and abolished by the PET inhibitors 3-(3, 4-dichlorophenyl)-1, 1-dimethylurea and 2, 5-dibromo-3-methyl-6-isopropyl-p-benzoquinone. These inhibitors reduced ABA-induced stomatal closure in all three species, as well as in the NADPH oxidase-lacking mutant atrboh D/F. However, an NADPH oxidase inhibitor did not fully eliminate ABA-induced ROS in the chloroplasts, and ABA-induced ROS were still observed in the guard cell chloroplasts of atrboh D/F. This study demonstrates that ROS generated through PET act as signaling molecules in ABA-induced stomatal closure and that this occurs in concert with ROS derived through NADPH oxidase..
2.	Kohji Yamamoto, Akifumi Higashiura, Aiko Hirowatari1, Naotaka Yamada,Takuya Tsubota, Hideki Sezutsu, Atsushi Nakagawa, Characterisation of a diazinonmetabolising glutathione Stransferase in the silkworm Bombyx mori by X-ray crystallography and genome editing analysis, Scientific REPORTS, 10.1038/s41598-018-35207-8, 8, 16835, 2018.11.
3.	Aiko Hirowatari, Sumiharu Nagaoka, Naotaka YAMADA, KOHJI YAMAMOTO, Structural characterization of the catalytic site of a Nilaparvata lugens delta-class glutathione transferase, Journal of Insect Biotechnology and Sericology, 86, 1-7, 2017.03.
4.	KOHJI YAMAMOTO, Aiko Hirowatari, Takahiro Shiotsuki, Naotaka YAMADA, Biochemical characterization of an unclassified glutathione　S-transferase of Plutella xylostella, Journal of Pesticide Science, 41, 4, 145-151, 2016.11.
5.	Kenj　Honda, Naotaka YAMADA, Riichiro　Yoshida, Hideshi　Ihara, Tomohiro Sawa, Takaaki Akaike, Sumio　Iwai, 8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis, PLANT AND CELL PHYSIOLOGY, 10.1093/pcp/pcv069, 56, 8, 1481-1489, 2015.08.
6.	KOHJI YAMAMOTO, Akifumi Higashiura, MD. Tofazzal Hossain, Naotaka YAMADA, Takahiro Shiotsuki, Atsushi Nakagawa, Structural characterization of the catalytic site of a Nilaparvata lugens delta-class glutathione transferase, Archives of Biochemistry and Biophysics, 566, 36-42, 2015.01.
7.	KOHJI YAMAMOTO, Yoichi Aso, Naotaka YAMADA, Catalytic function of an Epsilon-class glutathione　S-transferase of the silkworm, Insect Molecular Biology , 10.1111, 22, 5, 523-531, 2013.06.
8.	Takahiro Joudoi, Yudai Shichiri, Nobuto Kamizono, Takaaki Akaike, Tomohiro Sawa, Jun Yoshitake, 山田直隆, Sumio Iwaia, Nitrated Cyclic GMP Modulates Guard Cell Signaling　in ArabidopsisW, The Plant Cell, 10.1105, 25, 558-571, 2013.02.
9.	Kenjiro Furuta, Norihiro Fujita, Tsubasa Ibushi, Takahiro Shiotsuki, Naotaka Yamada and Eiichi Kuwano, Synthesis and anti-juvenile hormone activity of ethyl 4-[(6-substituted 2,2-dimethyl-2H-chromen-7-yl)methoxy]benzoates , Journal of Pesticide Science , 35, 4, 405-411 , 2010.05.
10.	N. Yamada, E. Kuwano,, Synthesis and bleaching activity of 1-ethyl- and 1-propyl-5-substituted imidazoles(II), J. Fac. Agr.,Kyushu Univ., 46 (1), 219-228, 2001.10.
11.	Yoshida, S., Furuta, K., Shirahashi, H., Ashibe, K., Fujita, N., Yamada. N ， Kuwano. E, Synthesis and Structure-Activity Relationship of a New Series of Anti-Juvenile Hormone Agents: Alkyl 4-(2-Benzylhexyloxy)benzoates and Ethyl 4-Substituted Benzoates. , J.Fac.Agr.,Kyushu Univ.,, 54(1),179-184, 2009.01.
12.	S. Hong, N. Yamada,A.Harada, S. Kawai and E. Kuwano, Inhibition of trans-Cinnamate 4-Hydroxylase by 4-amino-5aryl-2,3-dihydro-3H-1,2,4-triazole, J. Pestic. Science, 10.1584/jpestics.30.406, 30, 4, 406-408, 30(4), pp406-408, 2005.12.
13.	Watanabe, Y., Yamada. N ., Machida, T., Honjoh, K.， Kuwano，E． , Influence of Cold Hardening on Chlorophyll and Carotenoid in Chlorella vulgaris , J.Fac.Agr.,Kyushu Univ.,, 54(1),195-200(2009), 2009.01.
14.	Yoshida, S., Furuta, K., Ashibe, K., Fujita, N., Nishikawa, S., Yamada. N， Kuwano. E , Ethyl 4-[2-(Substituted Benzyl)hexyloxy]benzoates: Anti-Juvenile Hormone Agents with Juvenile Hormone Activity., J.Fac.Agr.,Kyushu Univ.,, 54(1),185-190(2009) , 2009.01.
15.	Naotaka Yamada, Daisuke Kusano,Eiich. Kuwano, Bleaching Activity of 4-Phenl-3-(substituted benzylthio)-4H-1,2,4-triazoles.Biosci.Biotech. and Biochem., 66(8) 1671-1676(2002), Bioscience Biotechnology and Biochemistry., (2002), 66, 8, 1671-1676, 66、8、pp1671-1676, 2002.08.
16.	Naotaka Yamada, Shinya Kawai, Eiichi Kuwano　他３名, 5-Aryl-1,3,4-oxadiazole-2-thiols as a New Series of trans-Cinnamate, Journal of Pesticide Science, 10.1584/jpestics.29.205, 29, 3, 205-208, 29,3, pp205-208, 2004.03.

Presentations

Show All Presentations >>

1.	Role of hydrogen sulfide as a signaling material in induction of stomata closure of salicylic acid. Naotaka Yamada, Daiki Shinboku, Sumio Iwai. The 2021 Meeting of the Japan Society for Bioscience, Biotechnology and Agrochemistry..
2.	Search for anti-ABA compounds by using ABA agonist, Quinabactin as a lead compound Kohei Taksugi, Yushiro Fukusaki, Naotaka Yamada (Faculty of agriculture, Kyushu Univ.), 45th Annual Meeting of the Pesticide Science Society of Japan.
3.	Biochemical analysis and crystal structure analysis using specific inhibitor Z302 of basidiomytesal yeast and plant-derived phenylalanine ammonia lyase. Takashi Nakashima, Takahiro Yoshimura, Daiki Tomitaka, Naotaka Yamada, Yoshizumi Ishino. The 2019 Joint Meeting of The West and Chushikoku Branch of the Japan Society for Bioscience, Biotechnology and Agrochemistry. .
4.	Changes in H2S, NO and H2O2 levels in guard cells during the guard closure induction by salicylic acid, Naotaka Yamada, Daiki Shinboku, Sumio Iwai. The 2019 Joint Meeting of The West and Chushikoku Branch of the Japan Society for Bioscience, Biotechnology and Agrochemistry..

Educational

Educational Activities

School of agriculture
　 :Lecture of Organic ChemistryI
　　　:Laboratory Course of Organic Chemistry ( Applied Bioscience course)

Graduate school
: Proseminar in Peticide Chemistry and Organic Synthesis I and II, Advanced Studies of Plant Protection I and II (Applied Genetics and Pest Management)

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