|Akihiko Yamaguchi||Last modified date：2020.06.03|
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Fishes are interesting group of organisms in which to analyze sex determination and gonad development because they have various type of sexuality. Recently, the medaka Y-specific sex determination gene, DMY which is a duplicated copy of autosomal DMRT1 was identified. In other fishes, however, no molecular information exists about the mode of sex determination, sex chromosomes or the process of gonad differentiation. Our goal is determination of the common molecular mechanism of gonad development of useful marine fishes at the molecular and cellular level, then bring it back to the our life, enviroment and society.
Please step into the world of the marine reproductive biology with us. .
Country of degree conferring institution (Overseas)
Field of Specialization
Reproductive Biology, Molecular Cell Biology
Total Priod of education and research career in the foreign country
Fishes are interesting group of organisms in which to analyze sex determination and gonad development because they have various type of sexuality. Recently, the medaka Y-specific sex determination gene, DMY which is a duplicated copy of autosomal DMRT1 was identified. In other fishes, however, no information exists about the mode of sex determination, sex chromosomes or the process of gonad differentiation. We study molecular mechanism of these process using kinds of fishes(goldfish, pufferfish, zebrafish, so on). Recently, we try to analyze the germ cell differntiation during early larvae of Japanese pufferfish, Takifugu rubripes which has the most compact genomes of all vertebrates and used as a good model for comparative genome analysis. At present, we have been investigating the transcription factors that are necesary for differentiation of germ cells. Aromatase is an important steroidogenic enzyme converts androgen to estroge.Brain type aromatase (CYP19B) has a unique characteristics because fish brain 100-1000 fold more proteins and activity than mammals. We have been studying the role of estrogen in fish brain as well as gonads and other somatic organs.
Research InterestsMembership in Academic Society
- The molecular study of gonadal sexual differntiation, development, maturationin and enviromental responsibility of Torafugu (Takifugu rubripes)
keyword : Torafugu, gonadal sexual differntiation, transcription factor, steroidgenic enzyme, ER, GTH, Rhodopsin, opsin
2000.10We analyze transcription factors, steroidogenic enzymes that works for sex-differentiation and development of the gonads. Recently, we target on the nuclear matrix that may be a key structure to understand molecular mechanism of gene expression system in germ cells..
- Molecular analysis of nuclear (germinal vesicle) structure and function in fish oocytes
keyword : ｌａｍｉｎ，ｐｒｏｔｅｉｎ ｋｉｎａｓｅ，ＭＰＦ,ｃｄｃ２，SR ｐｒｏｔｅｉｎ, ｏｏｃｙｔｅ ｍａｔｕｒａｔｉｏｎ，ｇｏｌｄｆｉｓｈ
- The Japan Society for Pituitary Research
- Zoological Society of Japan