Kyushu University Academic Staff Educational and Research Activities Database
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Hiroshi Shigeto Last modified date:2021.05.31

Graduate School
Undergraduate School
Other Organization

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Medical doctor, Philosophy of doctor
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
I am engaged in the study of neurological disease both for clinical and research. Basically, I have been using the method of neurophysiology. For the epilepsy, I have studied the feasibility of the magnetoencephalograpy for detecting the epileptic electrical discharges in patient.We created focal cortical dysplasia rat model,which aquires kindling phenomenon faster than normal control. These rat had spontaneous seizure arising from hippocampus. We also analysis brain epileptic magnetic activity using new methods of analysis. We analyze the scalp electroencephalogram, stereotactic electroencephalogram and electrocorticogram in order to reveal the influences of sleep, biological rhythm, memory and higher cortical function on the relationship between limbic system and neocortex.
Research Interests
  • Mechanism of accelerating forgetting of epilepsy patients
    keyword : epilepsy memory
  • Investigate the mechanisms of epileptogenesis using animal study and human MEG study
    keyword : spontaneous seizure, rat, MEG
  • Effect of cervical carotid artery cooling on cortical epileptic activity.
    keyword : epilepsy cooling cervical
    2006.04~2007.12We study the cooling effect on cortical epileptic electrical activity by the cooling of cervical carotid artery, which reduced brain temperature indirectly and non-invasively. .
  • Investigate the epileptogenicity of focal cortical dysplasia
    keyword : epilepsy focal cortical dysplasia
    2001.10~2011.04We study about the epileptogenicity of focal cortical dysplasia using freeze lesion rat model..
  • Study the effect of electrical stimulation on the generation and suppression of epileptic activity
    keyword : electrical stimulation epilepsy generation suppression
    2001.10~2011.03We made the rat model producing after discharge on neo-cortex. Using this model, we test the efficacy of electrical stimulation both for preventing and provoking seizures..
Academic Activities
1. Hiroshi Shigeto, Hippocampal modulation of auditory processing in epilepsy, Neurology and Clinical Neuroscience,, 2020.11.
1. Shimmura M, Uehara T, Ogata K, Shigeto H, Maeda T, Sakata A, Yamasaki R, Kira JI., Higher postictal parasympathetic activity following greater ictal heart rate increase in right- than left-sided seizures., Epilepsy Behav, 10.1016/j.yebeh.2019.05.026., 97, 161-168, 2019.08,
2. Matsubara T, Ogata K, Hironaga N, Uehara T, Mitsudo T, Shigeto H, Maekawa T, Tobimatsu S., Monaural 40-Hz auditory steady-state magnetic responses can be useful for identifying epileptic focus in mesial temporal lobe epilepsy., Clin Neurophysiol., 10.1016/j.clinph.2018.11.026., 130, 3, 341-351, 2019.03.
3. Yuji Kanamori, Hiroshi Shigeto, Minimum norm estimates in MEG can delineate the onset of interictal epileptic discharges: A comparison with ECoG findings, Neuroimage Clin., 2013.04.
4. Hiroshi Shigeto, 鎌田 崇嗣, Spontaneous seizures in a rat model of multiple prenatal freeze lesioning, Epilepsy Res., 105, 3, 280-291, 2013.08.
5. Hiroshi Shigeto, Lüders H, Systematic study of the effects of stimulus parameters and stimulus location on afterdischarges elicited by electrical stimulation in the rat., Epilepsy Res, 104, 17-25, 2013.03.
6. Takase K, Shigeto H, Kamada T, Ohyagi Y, Kira J., Efficacy of mediodorsal thalamic nucleus stimulation in a rat model of cortical seizure., Fukuoka Igaku Zasshi. , 100, 8, 274-80., 2009.08.
7. Takase K, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira J. , Cortical kindling in a focal freeze lesion rat model.
, J Clin Neurosci. , 2009 Jan;16(1):94-8. Epub 2008 Nov 18.
, 2008.11.
8. Takase KI, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira JI. , Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.
, Epilepsia. 2008 Mar 4 , Epilepsia. 2008 Mar 4
, 2008.04.
1. Mukaino T, Uehara T1, Yokoyama J, Okadome T, Sakata A, Arakawa T, Yokoyama S, Akamatsu 6, Shigeto H, Kira J-I, Time-dependent functional specialization of hippocampal subfields detected by MRI in patients with temporal lobe epilepsy, American Epilepsy Society Annual Meeting 2019, 2019.12.
2. Epileptic discharges in digital EEG.
3. Hideaki Tanaka, MD; Hiroshi Shigeto, MD, PhD; Shinji Ohara, MD, PhD; Toshio Matsushima, MD, PhD; Tooru Inoue, MD, PhD; Naoki Akamatsu, MD, PhD, Predictors of postsurgical seizure relapse and post-relapse after surgery of temporal lobe epilepsy in the era of new antiepileptic drugs, 33rd International Epilepsy Congress, 2019.06, [URL], Objective:
To assess prognostic factors predicting seizure recurrence after resective surgery for temporal lobe epilepsy patients who had chance to use new antiepileptic drugs (AEDs).

We retrospectively investigated surgical outcomes in patients with neocortical or medial temporal lobe epilepsy who underwent temporal lobe resection between May 2014 and June 2017, and were observed for a minimum of one and half year after the surgery. To identify independent predictors for seizure relapse, we first used the univariate analysis (gender, seizure-onset age, using preoperative AEDs treatment, surgical side, pathology, etc.) to find significance differences and then used Cox’s proportional hazards analyses for multivariate analysis using results of univariate analyses.

A total of 41 consecutive patients were included in this study. Estimated epileptogenic zone in neocortex, existence of inter-ictal epileptiform discharges after operation, and duration of disease before surgery were significantly associated with seizure relapse, whereas preoperative treatment of new AEDs did not change the outcome: (1) Neocortical temporal lobe epilepsy compared to medial temporal lobe epilepsy (hazard ratio [HR] 0.363, 95% confidence interval [CI] 0.162-0.809; p=0.013), (2) Postoperative inter-ictal epileptiform discharges on EEG (HR 0.475, 95% CI 0.240-0.939, p=0.032), (3) Shorter duration of disease (HR 0.965, 95% CI 0.942-0.990, p=0.005).

Our study disclosed that the patients with estimated epileptogenic zone in neocortex, postoperative inter-ictal epileptiform discharges, and shorter duration of disease before surgery are more likely to experience seizure recurrence postoperatively. Our results may be useful for selecting candidates for resective surgery in patients with temporal lobe epilepsy.
4. Low &fast activities of the mesial temporal in relation to hippocampal sclerosis.
5. Evaluation of epilepsy patients without abnormalities of EEG and brain MRI
6. Evaluation of epilepsy patients without the abnormalities of EEG and Neuro images.
Membership in Academic Society
  • Japanese society of sleep research
  • We developed a novel rat model demonstrating spontaneous temporal lobe seizures by prenatal freeze lesioning in the bilateral frontoparietal lobes. Our model suggests that FCD in the extratemporal lobes can induce hippocampal epileptogenicity. This model may help clarify the mechanisms underlying temporal lobe epilepsy.
  • Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.
    Epilepsia. 2008 Jun;49(6):997-1010.
Educational Activities
In the undergraduate teaching curriculum, I give the lecture about epilepsy, sleep and electroencephalography. For the postgraduate education, I direct the researches based on the neurophysiology.
Professional and Outreach Activities
Chief of the committee regarding regional and international relationship .