Kyushu University Academic Staff Educational and Research Activities Database
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YOICHIRO OGINO Last modified date:2020.06.01

Associate Professor / Section of Fixed Prosthodontics, Division of Oral Rehabilitation
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School
Administration Post

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
Education for dental student and post-graduate student
Education for dental residents
Principal Investigator of Kyushu University Hospital
Research for clinical evaluation of prosthodontic treatment (effects of prosthodontic treatment on edentulous patients, maxilloafacial Prosthetic patients,, combination syndrome)
A dentist for clnical trial ans research of novel bone substitute, dental implant and GBR membrane
Chief dentist for maxillofacial prosthodontics
Research Interests
  • Clinical evaluation of all ceramic crown
    keyword : all ceramic crown
  • Clinical research of GBR membrane
    keyword : GBR
  • Clinical research of monolithic zirconia crown adhesion
    keyword : monolithic zirconia crown
  • Clinical assessment of novel bone substitute
    keyword : bone substitute
  • Oral function and QoL evaluation in Maxillofacial Prosthetic patients
    keyword : Maxillofacial Prostheses
  • Clinical evaluation of monolithic zirconia crowns
    keyword : monolithic zirconia crowns
  • Interaction between proinflammatory cytokine and bone morphogenetic protein
    keyword : proinflammatory cytokine  bone morphogenetic protein
  • Clinical evaluation of novel implant
    keyword : implant
  • Clinical evaluation of CAD/CAM molar crown with hybride resin
    keyword : CAD/CAM、hybride resin、molar crown
  • Clinical Trial of novel bone substitute
    keyword : bone substitute、Implant
  • Prosthetic treatment for an adult oeteopetrosis patient
    keyword : oeteopetrosis, Prosthetic treatment
  • effect of surface topography on cellular functions
    keyword : Ti, implant, Cell
  • Prothsodontic management for combination syndrome patients
    keyword : combination syndrome  dental implants removable denture
  • The effect of osteoporosis on dental implants
    keyword : osteoporosis implant
  • Multicenter research for the prosthodontic treatment for SDA patients
    keyword : SDA
  • Biological study for osseointegration by inhibition of extraction sockets resorption
    keyword : teeth extraction, inhibition of bone resorption
  • Bone Response to Implant Placement Torque
    keyword : Implant, Insertion torque, osseointegration
  • Clinical Application of Growth Factors in Dntistry
    keyword : growth factor
  • Biological Approach for Alveolar Bone Regeneration
    keyword : osteoblast, osteoclast
    2000.04~2005.12Research for alveolar bone regeneration.
Current and Past Project
  • Osteoimmunologic approach to titanium disk
  • Clinical assessment of maxillofacial prostheses subjectively and objectively
  • Assessment of the effect of surface topogaphy and hydrothemal teratment on surface chemistry and bone induction
  • Examnination of cellular functions on various Ti surface topography
  • The effect of osteoporosis on stable osseointegrated implants
Academic Activities
1. Koga S, Ogino Y, Fujikawa N, Ueno M, Kotaki Y, Koyano K., Oral health-related quality of life and oral hygiene condition in patients with maxillofacial defects: A retrospective analysis.
, J Prosthodont Res., 10.1016/j.jpor.2019.11.003., 2020.02, Purpose: The purpose of this study was to evaluate the effect of oral rehabilitation (maxillofacial prosthetic intervention and oral hygiene instruction) on oral health-related Quality of Life (OHRQoL) and oral hygiene condition in patients with maxillofacial defects and to explore the correlation between them in these patients.
Methods: Twenty-five patients with maxillofacial defects who had been treated since April 2016 to March 2018 were included in this study. The scores of the Oral Health Impact Profile (OHIP) and O’Leary’s Plaque Control Record (PCR) were also identified as the scores of OHRQoL and oral hygiene condition, respectively. Statistical analyses were performed to compare between the scores of “pre” and “post” prosthetic treatment and to evaluate patient-related factors influencing these variables (age, the number of residual teeth and occlusal supports, and occlusal units (OUs)). The effect of combined chemo-radiotherapy (CRT) on each score was also assessed statistically. Furthermore, the correlation of OHIP and PCR scores was explored statistically.
Results: Both oral rehabilitations could significantly improve OHIP and PCR scores. Significant correlations of the change of OHIP scores with age and OUs were detected. CRT had no significant effect on OHIP and PCR scores. No correlations between OHIP and PCR were observed.
Conclusions: Although oral rehabilitation such as maxillofacial prosthetic treatment and oral hygiene instruction would be highly effective for improvement of OHRQoL and oral hygiene condition in patients with maxillofacial defects, there was no correlation between them..
2. Nishimura T, Ogino Y, Ayukawa Y, Koyano K., Influence of the wettability of different titanium surface topographies on initial cellular behavior., Dent Mater J., 2018.06, This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability..
3. Gunge H, Ogino Y, Kihara M, Tsukiyama Y, Koyano K., Retrospective clinical evaluation of posterior monolithic zirconia restorations after 1 to 3.5 years of clinical service., J Oral Sci., 24, 60, 154-158, 2018.03.
4. TOSHIO KAKU, YOICHIRO OGINO, Yasuyuki Matsushita, 古谷野 潔, Technique for identifying keratinized gingival tissue and soft tissue morphology on 3-dimensional implant-planning software images., J Prosthet Dent. , doi: 10.1016/j.prosdent., 116, 1, 21-24, 2016.05.
5. YOICHIRO OGINO, Ruiwei Liang, Daniela Mendonca, Gustavo Mendonca, Masako Nagasawa, kiyoshi koyano, Lyndon F. Cooper, RhoA-Mediated Functions in C3H10T1/2 Osteoprogenitors Are Substrate Topography-Dependent., J Cell Physiol, doi: 10.1002/jcp.25100., 231, 3, 568-575, 2016.03.
6. 荻野 洋一郎, 鮎川 保則, 富田陽子, 古谷野 潔, Prosthetic aspects in adult osteopetrosis., J Prosthet Dent., 2014.10, Osteopetrosis (OP) is a rare condition characterized by skeletal sclerosis caused by dysfunctional osteoclasts. Though many reports have described severe infantile-malignant autosomal recessive OP, few have described the prosthetic management of adult OP. This report discusses the prosthetic treatment of adult OP. Although prosthodontists should try to reconstruct occlusal function as much as possible, a conservative prosthodontic approach may be a reasonable and recommended treatment option for minimizing the risk of further osteomyelitis and osteonecrosis..
7. YOICHIRO OGINO, Kihara Masafumi, Junichi Yamda, Kohei Toriya, kiyoshi koyano, Implant Treatments for Edentulous Maxilla with Anterior Hyperfunction., J Oral Implantol., doi: 10.1563/AAID-JOI-D-13-00123. , 41, 6, 731-735, 2015.12.
8. Daisuke Kondo, YOICHIRO OGINO, Yasunori AYUKAWA, Shinji Sakai, KOEI KAWAKAMI, kiyoshi koyano, Bone Regeneration of Tibial Defects in Rats with Enzymatic Hydrogelation of Gelatin Derivative and Recombinant Human Platelet-Derived Growth Factor-BB Complex, INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 28, 5, 1377-1385, 2013.09.
9. Ogino Y. Ayukawa Y. Kukita T. Atsuta I. Koyano K. , Platelet-rich plasma suppresses osteoclastogenesis by promoting the secretion of osteoprotegerin.

, Journal of Periodontal Research, 44(2):217-24, 2009 Apr. , 2009.04.
10. Yoichiro Ogino, Kohei Toriya, Yasunori Ayukawa, Kiyoshi Koyano, Prosthetic and Surgical Managements of Peri-implantitis at the Flap Reconstruction Site., Prosthodontic Research & Practice Vol.7 No.2, 2008, Vol.7 No.2, 231-233, 2008, 2008.07.
11. Yoichiro Ogino,Yasunori Ayukawa,Toshio Kukita,Kiyoshi Koyano, The contribution of platelet-derived growth factor, transforming growth factor-β1 and insulin-like growth factor-I in platelet-rich plasma (PRP) to the proliferation of osteoblast-like cells., Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics., 2006.05.
12. Yoichiro Ogino, DDS, PhD,a Yasunori Ayukawa, DDS, PhD,b Yoshihiro Tsukiyama, DDS, PhD,c, The effect of platelet-rich plasma on the cellular response of rat bone
marrow cells in vitro, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 10.1016/j.tripleo.2005.03.007, 100, 3, 302-307, Oral Surg Oral Med Oral Pathol Oral Radiol
Endod 2005;100:302-7, 2005.10.
1. Ogino Y, Matsushita Y, Koyano K, Clinical and radiological assessment of maxillary sinus floor augmentation using carbonate apatite: A 30-month follow-up study, 18th Biennial Meeting of ICP and 43rd Annual Meeting of the EPA, 2019.09.
2. Ogino Y, Matsushita Y, Koyano K, Maxillary sinus floor augmentation using carbonate apatite granules: A 30-month follow-up study., 6th Biennial Joint Congress of KAP-CPS-JPS, 2019.03.
3. Ogino Y, Koga S, Fujikawa N, Koyano K, Advantages and disadvantages of preoperative-restored implant prostheses after oral tumor resection. , ISMR-AAMP 4th joint meeting, 2017.11.
4. YOICHIRO OGINO, LYNDON F COOPER, 古谷野 潔, Specific acid-treated surface topography alter hydrophilicity and osteogenic cellular responses., 16th biannual meeting of International Collage of Prosthodontics, 2015.09.
5. YOICHIRO OGINO, Lyndon F. Cooper, kiyoshi koyano, Topography influences cellular responses and RhoA activity of titanium surface-adherent cells. , Congress of Asian Academy of Prosthodontincs, 2014.11.
6. YOICHIRO OGINO, Lyndon F. Cooper, kiyoshi koyano, Topography influences cellular responses and RhoA activity of titanium surface-adherent cells. , Congress of Asian Academy of Prosthodontincs, 2014.11.
7. YOICHIRO OGINO, Lyndon F. Cooper, kiyoshi koyano, Topography influences cellular functions and RhoA activity of titanium surface-adherent cells., 9th International Wrokshop on Biomaterials in Interface Science, 2014.08, Purpose: RhoA, one of Rho-family of GTPases, is known to influence cell adhesion and motility through organization of the actin cytoskeleton in response to various stimuli. The aim of this study was to investigate cellular functions and RhoA activities of the adherent cells on titanium substrates with three kinds of topography.
Materials and Methods: Three kinds of surface topography Ti disks were prepared. Smooth (S) surfaces were passivated with 30% HNO3. HCl-treated (H1) surfaces were grit-blasted with 100-μm aluminum oxide (Al2O3) particles, subsequently treated with 5N HCl and passivated with 30% HNO3. H2O2+H2SO4-treated (H2) surfaces grit-blasted with 100-μm Al2O3 particles and subsequently treated with 30% H2O2 and 2N H2SO4. These surfaces were characterized by SEM analysis and the measurement of surface roughness. To evaluate the effect of surface topography and RhoA inactivation on cellular functions, murine mesenchymal stem cells were cultured on each disk and cell morphology, RhoA activity, wound healing rates (cell migration) and osteogenic markers’ expressions were investigated with or without RhoA inhibitor (C3).
Results: Each disk showed a specific surface topography and surface roughness analysis indicated the highest roughness in H1 surfaces (H1>H2>S). Cell morphology was influenced by surface topography and C3. RhoA was activated in a surface roughness-dependent manner. The highest wound healing rate was observed on S surface. RhoA inhibition also enhanced cell migration on S and H1 surfaces, but not H2 surface. The expression of osteogenic markers was inhibited by C3 in S and H1 adherent cells, but not in H2 adherent cells.
Conclusions: Topography influences cellular functions and RhoA activity. However, the effect of RhoA inhibition on cellular functions may be in a surface topography- dependent manner.
8. KATHARINE AVANESYAN K, YOICHIRO OGINO, Lyndon Cooper, Monocytic Prostaglandin as a Chemotactic Agent for MSC Homing, American Association for Dental Research (AADR) Annual Meeting & Exhibition, 2014.03.
9. YOICHIRO OGINO, Ruiwei Liang, Daniela Mendonca, Gustavo Mendonca, Lyndon F Cooper, Kiyoshi Koyano, Topography and RhoA on Initial Cell Behaviors, the 91st IADR General Session & Exhibition, 2013.03.
Membership in Academic Society
  • Japanese Society of Gerodontology
  • Japanese Academy of Maxillofacial Prosthetics
  • International Association for Dental Research
  • International college of prosthodontists
  • Maxillary sinus floor augmentation using carbonate apatite granules: A 30-month follow-up study.
Educational Activities
Education of basic and clinical prosthodontics (crown-fixed partial denture, removable denture)
Education of basic and clinical dental implantology
Education of basic bone regeneration research
Education of oral function