Kyushu University Academic Staff Educational and Research Activities Database
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Masamichi Kamihira Last modified date:2023.06.20

Professor / Molecular and Biochemical Systems Engineering
Department of Chemical Engineering
Faculty of Engineering

Graduate School
Undergraduate School

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Academic Degree
Doctor of Engineering
Country of degree conferring institution (Overseas)
Field of Specialization
Biochemical Engineering
Total Priod of education and research career in the foreign country
Outline Activities
Biological systems have generated ingeniousness by evolving their processes from an individual level to combined levels (from gene to cell, tissue/organ and organism). The aim of study in our laboratory is development of new biotechnology through analyzing ingeniousness of biological systems and life phenomena and through trying to reconstruct them artificially. 1. Gene transfer technique. 2. Artificial organs. 3. Transgenic animals. 4. Stem cell technology. 5. Molecular biology of functional cells. 6. Production of useful substances using cultured cells.
Research Interests
  • Development of novel cell/tissue engineering techniques
    keyword : Cell Engineering, Tissue Engineering, Medical Engineering, Artificial Organs, Stem Cells
  • Gene delivery for animal cells
    keyword : Artificial virus, gene transfer, hybrid carrier, gene amplification, chromosal editing
  • Production of biopharmaceuticals using transgenic avian bioreactors
    keyword : Transgenic avians, living bioreactors, embryo manipulation, biopharmaceutical proteins
Academic Activities
1. Masamichi Kamihira, Ken-ichi Nishijima, Shinji Iijima, Recent Progress of Biochemical and Biomedical Engineering in Japan II (Advances in Biochemical Engineering/Biotechnology Vol. 91), Springer-Verlag, Transgenic birds for the production of recombinant proteins (pp171〜189), 2004.06.
2. Masamichi Kamihira, Aqueous Two-Phase Systems: Methods and Protocols (Methods in Biotechnology 11), Humana Press, Chapter 34: Integration of extraction with affinity precipitation (pp371〜379)
Chapter 35: Affinity partitioning using magnetic two-phase systems (pp381〜390), 2000.10.
1. Masamichi KAMIHIRA, Yoshinori KAWABE, Takuya SHINDO, Ken-ichiro ONO, Kazuhisa ESAKA, Takashi YAMASHITA, Ken-ichi NISHIJIMA, and Shinji IIJIMA, Production of chimeric monoclonal antibodies by genetically manipulated chickens, Journal of Biotechnology, Vol. 141, No. 1-2, pp. 18-25, 2009.04.
2. Masamichi KAMIHIRA, Ken-ichiro ONO, Kazuhisa ESAKA, Ken-ichi NISHIJIMA, Ryoko KIGAKU, Hiroyuki KOMATSU, Takashi YAMASHITA, Kenji KYOGOKU, and Shinji IIJIMA, High-level expression of scFv-Fc fusion protein in serum and egg white of genetically manipulated chickens by using a retroviral vector, Journal of Virology, 10.1128/JVI.79.17.10864-10874.2005, 79, 17, 10864-10874, Vol. 79, No. 17, pp. 10864-10874, 2005.09.
Membership in Academic Society
  • The Society of Chemical Engineers, Japan
  • The Society for Biotechnology, Japan
  • Japanese Association for Animal Cell Technology
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Molecular Biology Society of Japan
  • The Chemical Society of Japan
  • Japan Bioindustry Association
  • 31th Outstanding paper award, The Society for Biotechnology, Japan, 2023.9 (J. Biosci. Bioeng., 133(3), 273-280 [2022])
  • 24th Outstanding paper award, The Society for Biotechnology, Japan, 2016.9 (J. Biosci. Bioeng., 120(1), 99-106 [2015])
  • 17th Outstanding paper award, The Society for Biotechnology, Japan, 2009.9 (J. Biosci. Bioeng., 105(5), 454-459 [2008])
  • 15th Outstanding paper award, The Society for Biotechnology, Japan, 2007.9 (J. Biosci. Bioeng., 102(4), 297-303 [2006])
  • 2nd Outstanding paper award, The Society for Biotechnology, Japan, 1994.10 (J. Ferment. Bioeng., 76(2), 128-133 [1993])
  • 16th Terui award, The Society for Biotechnology, Japan, 1993.11, Production and Separation of Useful Biological Substances in Animal Cell Culture
Educational Activities
Undergraduate course
+ Chemical Engineering Stoichiometry
+ Bioprocess Engineering II

Graduate course
+ Life Process Engineering
+ Cell & Tissue Engineering