Zhou Wu | Last modified date:2024.04.18 |
Associate Professor /
Department of Aging Science and Pharmacology
Department of Dental Science
Faculty of Dental Science
Department of Dental Science
Faculty of Dental Science
Graduate School
Undergraduate School
Administration Post
Other
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Homepage
https://kyushu-u.elsevierpure.com/en/persons/hiro-take
Reseacher Profiling Tool Kyushu University Pure
Academic Degree
PhD of Detal sciences, Master of Medical sciences, Bachelor of Medicine
Country of degree conferring institution (Overseas)
Yes Bachelor Master
Field of Specialization
Neuronimmunity, aging
Total Priod of education and research career in the foreign country
15years00months
Outline Activities
Consistently for years, I have been researching the effects of chronic systemic inflammation including periodontal disease on the brain. I am promoting the elucidation of the signaling pathway of chronic systemic inflammation to the brain and the mechanism that influences it, and my research interests are the brain and systemic immune organs. As development of pathological mechanism elucidation, I am also searching for natural substances that “control inflammation”.
Research
Research Interests
Membership in Academic Society
- The roles of phagocytes in aging
keyword : aging phagocytes
2005.05~2010.05. - Impact ofchronic systemic brain inflammation on brain functions
keyword : systemic inflammation, neuroinflammation, neuroimmunity, leptomeningeal cell, brain aging
1996.10.
- Clinical research has shown that there is a positive correlation between periodontal disease and the progression of Alzheimer's disease (AD), and the components of periodontal pathogen P. gingivalis have been detected in autopsy brains of patients with AD. It has been proposed that periodontal disease is an exacerbating factor in AD, but its involvement in the early pathogenesis of AD is still unclear. We have consistently analyzed the effects of systemic inflammation, including periodontal disease, on brain function for many years. We have shown that P. gingivalis/LPS induces AD-like brain pathology and systemic pathology that promotes AD-like brain pathology in normal middle-aged mice. It has been discovered that amyloid (A) is imported into the brain via brain barrier cells, which are the interface between the circulating blood and the brain. Synaptic disorders are an extremely early pathological condition before the onset of AD. In this project, we investigated the effects of P. gingivalis on disruption of brain barrier microenvironment homeostasis, synaptic disorders as well as learning and memory functions. We aim to verify the involvement of periodontal disease in early AD pathology and elucidate its molecular mechanism.
Books
Reports
Papers
Presentations
- Asian College of Neuropsychopharmacology
- Socitity of Neuroscience
- Involvement of brain pericyte damage in neuropathological
changes associated with lysosomal storage
Educational
Educational Activities
Enforce the lectures for undergraduate and graduate students school as a faculty member, conducte research guidance for undergraduates and graduate studentsand write the research papers as PI (principle investigator).
Other Educational Activities
- 2023.04.
- 2021.03.
- 2021.09.
- 2019.03.
- 2018.06.
Social
Professional and Outreach Activities
As a member of the Japan BPW (Business & Professional Woman) Federation Fukuoka Club (Niji no Kai), I strive to improve the social status and vocational standards of working women and educate female students through various activities. I had served as an officer of the Niji no Kai from 2019 to 2021(planning and international affairs), and I has been a member of the International and Development Committee of the International Women's Year Liaison Committee since 2021. We also hold seminars for citizens all over the country through the Private Grant Foundation. He is in charge of managing and giving lectures on international symposiums held at the Institute of Dentistry, giving lectures overseas, and conducting joint research with overseas..
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