Kyushu University Academic Staff Educational and Research Activities Database
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Zhou Wu Last modified date:2021.11.26

Associate Professor / Department of Aging Science and Pharmacology
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School
Administration Post

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
PhD of Detal sciences, Master of Medical sciences
Country of degree conferring institution (Overseas)
Yes Master
Field of Specialization
Neuronimmunity, aging
Total Priod of education and research career in the foreign country
Outline Activities
Consistently for years, I have been researching the effects of chronic systemic inflammation including periodontal disease on the brain. I am promoting the elucidation of the signaling pathway of chronic systemic inflammation to the brain and the mechanism that influences it, and my research interests are the brain and systemic immune organs. As development of pathological mechanism elucidation, I am also searching for natural substances that “control inflammation”.
Research Interests
  • The roles of phagocytes in aging
    keyword :  aging phagocytes
  • Impact ofchronic systemic brain inflammation on brain functions
    keyword : systemic inflammation, neuroinflammation, neuroimmunity, leptomeningeal cell, brain aging
Academic Activities
1. Nakanishi H, Wu Z, Microglia-aging and pain: Microglial cathepsin B-dependent IL-1 production, In: Interleukin-1: Genetics, Inflammatory Mechanisms and Role in Disease, Nova Science Publishers, pp. 143-156, 2013.06.
2. Wu Z, Nakanishi H, TNF-a signaling and cathepsin B, In: Tumor Necrosis Factor: Structure. Enzyme Regulation and Role in Health and Disease, Nova Science Publisher Inc, pp. 113-128, 2013.06.
3. Zhou Wu and Hiroshi Nakanishi, Neuroimmunology Research Focus
Chapter 4
Age-Dependent Differential Activation Profiles of Glial Cell by the Leptomeninges During Systemic Inflammation
, Nova Science Pulishers, Inc., pp. 101-118., 2007.09.
1. Wu Z, Yu J, Zhu A, Nakanishi H, Nutrients, Microglia Aging, and Brain Aging, Oxid Med Cell Longev, 2016:7498528, 2016.06.
1. Muzhou Jiang, Xinwen Zhang, Xu Yan, Shinsuke Mizutani, Haruhiko Kashiwazaki, Junjun Ni† and Zhou Wu, GSK3β is involved in promoting Alzheimer’s disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor proteinNL-F/NL-F knock-in mice., Brain Behav Immun., 10.1016/j.bbi.2021.08.213, 98, 1-12, 2021.09.
2. Zng F, Liu Y, Huang W, Qing H, Kadowaki T, Kashiwazaki H, Ni J, Wu Z, Mediates Cerebrovascular-related Amyloid β Accumulation After Porphyromonas Gingivalis Infection, Journal of Neurochemistry, 10.1111/jnc.15096, 1-13, 2020.06.
3. Jiang M, Meng J, Zeng F, Qing H, Hook G, Hook V, Wu Z, Ni J, Cathepsin B Inhibition Blocks Neurite Outgrowth in Cultured Neurons by Regulating Lysosomal Trafficking and Remodeling, Journal of Neurochemistry, 10.1111/jnc.15032, 1-13, 2020.04.
4. Nie, Ran; Wu, Zhou; Ni, Junjun; Zeng, Fan; Yu, Weixian; Zhang, Yufeng; Kadowaki, Tomoko ; Kashiwazaki, Haruhiko; Teeling, Jessica L. ; Zhou, Yanmin, Porphyromonas gingivalis Infection Induces Amyloid-β Accumulation in Monocytes/Macrophages, Journal of Alzheimer's Disease, 72(2):479-494, 2019.11.
5. Junjun Ni, Hiro Take, Veronika Stoka, Jie Meng, Yoshinori Hayashi, Christoph Peters, Hong Qing, Vito Turk, Hiroshi Nakanishi, Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice, Aging cell, 10.1111/acel.12856, 18, 1, 2019.02.
6. Zhu A, Wu Z, Zhong X, Ni J, Li Y, Meng J, Du C, Zhao X, Nakanishi H, Wu S, Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude, J. Alzheimer's Dis, 63(2), 551-560, 2018.06.
7. Hiro Take, Junjun Ni, Yicong Liu, Jessica L. Teeling, Fumiko Takayama, Alex Collcutt, Paul Ibbett, Hiroshi Nakanishi, Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice, Brain, Behavior, and Immunity, 10.1016/j.bbi.2017.06.002, 65, 350-361, 2017.10.
8. Junjun Ni, Hiro Take, Jie Meng, Aiqin Zhu, Xin Zhong, Shizheng Wu, Hiroshi Nakanishi, The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells, Oxidative Medicine and Cellular Longevity, 10.1155/2017/7984327, 2017, 2017.01.
9. NI JUNJUN, Wu Z, Christoph Peterts, Kenji, Yamamoto, Hong Qin, Hiroshi Nakanishi, The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage, J. Neurosci, 10.1523/JNEUROSCI.1599-15.2015, 35, 36, 12488-501, 2015.09.
10. Liu Y, Wu Z, Zhang XW, Ni J, Yu W, Zhou Y, Hiroshi Nakanishi, Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS., Mediators Inflamm., 10.1155/2013/407562, 2013:407562, 2013.12.
11. Hiro Take, Li Sun, Sadayuki Hashioka, Sheng Yu, Claudia Schwab, Ryo Okada, Yoshinori Hayashi, Patrick L. McGeer, Hiroshi Nakanishi, Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia, Neurobiology of Aging, 10.1016/j.neurobiolaging.2013.05.018, 34, 12, 2715-2725, 2013.12, Although chromogranin A (CGA) is frequently present in Alzheimer's disease (AD), senile plaques associated with microglial activation, little is known about basic difference between CGA and fibrillar amyloid-β (fAβ) as neuroinflammatory factors. Here we have compared the interleukin-1β (IL-1β) production pathways by CGA and fAβ in microglia. In cultured microglia, production of IL-1β was induced by CGA, but not by fAβ. CGA activated both nuclear factor-κB (NF-κB) and pro-caspase-1, whereas fAβ activated pro-caspase-1 only. For the activation of pro-caspase-1, both CGA and fAβ needed the enzymatic activity of cathepsin B (CatB), but only fAβ required cytosolic leakage of CatB and the NLRP3 inflammasome activation. In contrast, fAβ induced the IL-1β secretion from microglia isolated from the aged mouse brain. In AD brain, highly activated microglia, which showed intense immunoreactivity for CatB and IL-1β, surrounded CGA-positive plaques more frequently than Aβ-positive plaques. These observations indicate differential pathways for the microglial IL-1β production by CGA and fAβ, which may aid in better understanding of the pathological significance of neuroinflammation in AD..
12. Wu, Z., Tokuda, Y., Zhang, X-W., Nakanishi, H., Age-dependent responses of glial cells and leptomeninges during sytemic inflammation., Neurobiology of Disease, 32, 543-551, 2008.10.
1. Yebo Gu, Junjun Ni, Zhou Wu, Ichiro Takahashi, Chronic systemic exposure of Lipopolysaccharide from Porphyromonas gingivalis induces memory decline through the upregulation of the bone loss promotion molecule IL-17 in middle-aged mice, 第72回日本薬理学会西南部会, 2019.11.
2. Yebo Gu, Junjun Ni, Zhou Wu, Ichiro Takahashi, Chronic systemic exposure of PgLPS induces long bone loss and cognitive decline in middle-aged mice, 第78回日本矯正歯科学会, 2019.11.
3. Yebo Gu, Junjun Ni, Muzhou Jiang, Zhou Wu, Ichiro Takahashi, Chronic systemic exposure of Lipopolysaccharide from Porphyromonas gingivalis
induces Memory decline and Bone loss in Middle-aged Mice, 6th Congress of ASCNP, 2019.10.
4. Fan Zeng, Junjun Ni, Zhou Wu , Porphyromonas gingivalis infection increases RAGE production in
hCMEC/D3 cell line, 6th Congress of ASCNP, 2019.10.
5. Wanyi Huang, Junjun Ni, Zhou Wu,, Porphyromonas gingivalis infected Leptomeningeal Cells Reduces Synapses Proteins in Primary Cultured Neurons, 6th Congress of AsCNP, 2019.10.
6. Muzhou Jiang, Junjun Ni, Yebo Gu, Zhou Wu, Microglia induces tau hyperphosphorylation of cultured neurons after exposure to Porphyromonas gingivalis LPS, 6th Congress of ASCNP, 2019.10.
7. Zhou WU, Inflammation and Lysosomal Enzymes: Prevention Approach of Cognitive Decline, Neurology Conference , 2019.06.
Membership in Academic Society
  • Asian College of Neuropsychopharmacology
  • Society of Neuroscience
  • Involvement of brain pericyte damage in neuropathological
    changes associated with lysosomal storage
Educational Activities
Enforce the lectures for undergraduate and graduate students school as a faculty member, conducte research guidance for undergraduates and graduate studentsand write the research papers as PI (principle investigator).
Other Educational Activities
  • 2019.03.
  • 2018.06.