Kyushu University Academic Staff Educational and Research Activities Database
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Takeshi Mori Last modified date:2024.04.01

Associate Professor / laboratory of functional organization chemistry
Department of Applied Chemistry
Faculty of Engineering

Graduate School
Undergraduate School
Other Organization

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Polymer Science
Total Priod of education and research career in the foreign country
Outline Activities
I am trying to understand biological phenomena in chemistry viewpoint (molecular aggregate, chemical reaction) and apply them to medical field. Now I am creating immunomodulatory molecules, efficient therapy of tumor, and a highly accurate diagnostic technique based on the fluorescence method.
Research Interests
  • Oral delivery of antibiotics via protecting intestinal microbiome
    keyword : Oral delivery, antibiotics, intestinal microbiome
  • Drug delivery system by targeting MHC
    keyword : MHC, drug delivery
  • Therapy of inflammatory diseases by using vitamin containing lipid nanoparticles
    keyword : viamin, lipid, inflammatory bowel disease, asthma
  • minimal mimetic of transmembrane protein
    keyword : transmembrane protein
  • endogenous IgG-recruting molecule for cancer therapy
    keyword : antibody medicine, cancer
  • Efficeint delivery of nanomedicine to cancer by using nitric oxide
    keyword : nitric oxide, cancer, nanomedicine
  • Functionalization of immune cells via chemical transformation
    keyword : immune cell, macrophage, circulating tumor cell
  • co-receptor
    keyword : cell surface engineering
  • Co-endocytosis
    keyword : cell surface engineering
  • Polymeric material for protein delivery
    keyword : delivery, nano-machine
  • Cell membrane pearmeable polymer
    keyword : cell membrane, polymer
  • Efficient endocytosis based on soft engineering of cell surface
    keyword : cell, endocytosis, polymer
  • Global screening of physiological enviroment responsive peptides and their applications as biomaterials
    keyword : biomaterials, peptide, environment-responsive
  • Gene carrier that can respond to cell signal for cancer-specif gene thrapy
    keyword : gene therapy, siganl transduction
  • Highly sensitive peptide array for drug screening and diagnosis
    keyword : peptide array, diagnosis, drug screening
  • temperature-responsive polymer with large hysteresis for biomedical application
    keyword : biomedical polymer, drug delivery system
Academic Activities
1. S. Li, H. Toriumi, D. Takahashi, T. Kamasaki, Y. Fujioka, S. Nagatoishi, J. Li, Y. Liu, T. Hosokawa, K. Tsumoto, Y. Ohba, Y. Katayama, D. Murakami, K. Hase, T. Mori, Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles, Biomaterials, 303, 122381, 2023.11.
2. C. Tateishi, A. Koga, A. Matsuura, R. Kaneko, K. Tanito, T. Nii, Akihiro Kishimura, T. Mori, Y. Katayama, A human cell orthogonal enzyme β-D-galacturonidase for sensitive detection of antigen proteins, Analyst, 148, 2237-2244, 2023.04.
3. T. Hosokawa, S. Tanaka, T. Mori, Y. Baba, and Y. Katayama, Quiescent B cells acquire sensitivity to cell cycle arresting agents by B cell receptor stimulation, Biol. Pharm. Bull., 45, 847-850, 2022.10.
4. S. Li, K. Yakabe, K. Zai, Y. Liu, A. Kishimura, K. Hase, Y.-G. Kim, T. Mori, Y. Katayama, Specific adsorption of a β-lactam antibiotic in vivo by an anion-exchange resin for protection of the intestinal microbiota, Biomater. Sci., 9, 7219-7227, 2021.11.
5. K. Sasaki, M. Harada, T. Yoshikawa, H. Tagawa, Y. Harada, Y. Yonemitsu, T. Ryujin, A. Kishimura, T. Mori, Y. Katayama, Fc-binding antibody-recruiting molecules targeting prostate-specific membrane antigen: defucosylation of antibody for efficacy improvement,, ChemBioChem, 22, 496-500, 2021.02.
6. Y. Mu, Y. Kinashi, J. Li, T. Yoshikawa, A. Kishimura, M. Tanaka, T. Matsui, T. Mori, K. Hase, Y. Katayama, Polyvinyl butyrate nanoparticles as butyrate donors for colitis treatment, ACS Applied Bio Mater., 4, 2335, 2021.01.
7. X. Sun, R. Tokunaga, Y. Nagai, R. Miyahara, A. Kishimura, S. Kawakami, Y. Katayama, T. Mori, Ligand design for specific MHC class I molecules on the cell surface, Biochemistry, 59, 4646, 2020.10.
8. K. Yuzuriha, K. Yakabe, H. Nagai, S. Li, T. Zendo, K. Zai, A. Kishimura, K. Hase, Y-G Kim, T. Mori, Y. Katayama, Protection of gut microbiome from antibiotics: development of a vancomycin-specific adsorbent with high adsorption capacity, Biosci. Microbio. Food Health, 39, 128-136, 2020.06, 腸内細菌叢を破壊することが知られる抗生物質(バンコマイシン)を腸間で特異的に吸着する粒子を開発し、実際に、腸内細菌を保護することを示した。また細菌叢の破壊に由来する感染症からマウスを保護することができた。.
9. K. Yuzuriha, A. Yoshida, S. Li, A. Kishimura, T. Mori, Y. Katayama, Synthesis of peptide conjugates with vitamins for induction of antigen-specific immunotolerance, J. Peptide Sci., 26, e3275, 2020.06.
10. K. Noguchi, T. Shimomura, Y. Ohuchi, M. Ishiyama, M. Shiga, T. Mori, Y. Katayama, Y. Ueno, Β-galactosidase-catalyzed fluorescent reporter labeling of living cells for sensitive detection of cell surface antigens, Bioconjugate Chem., 31, 1740-1744, 2020.05, beta-ガラクトシダーゼを酵素として、一細胞の抗原を高感度に増感検出する方法(蛍光がターンオンし、細胞に共有結合して脱離しない)の開発に初めて成功した。.
11. T. Ryujin, T. Shimizu, R. Miyahara, D. Asai, R. Shimazui, T. Yoshikawa, A. Kishimura, T. Mori, T. Ishida, Y. Katayama, Blood retention and antigenicity of polycarboxybetaine-modified liposomes, Int. J. Pharm. , 586, 119521, 2020.04.
12. K. Sasaki, M. Harada, Y. Miyashita, H. Tagawa, A. Kishimura, T. Mori, Y. Katayama,, Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses, Chem. Sci., 11, 3208-3214, 2020.03, 抗体医薬を低分子化合物で置き換えることを企図し、がん細胞と内在性の抗体を架橋する低分子を開発した。この分子は、in vitro, in vivoで抗がん活性を示した。.
13. H. Tagawa, K. Maruyama, K. Sasaki, N. Konoue, A. Kishimura, M. Kanai, T. Mori, K. Oisaki, Y. Katayama, Induction of ADCC by folic acid-mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells, RSC Adv., 10, 16727-16731, 2020.03.
14. T. Yoshikawa, K. Q. Phan, H. Tagawa, K. Sasaki, H. Feng, A. Kishimura, T. Mori, Y. Katayama, Modification of nitric oxide donors onto a monoclonal antibody boosts accumulation in solid tumors, Int. J. Pharm., 583, 119352, 2020.03.
15. T. Nobori, M. Kawamura, R. Yoshida, T. Joichi, K. Kamino, A. Kishimura, E. Baba, T. Mori, Y. Katayama,, Fluorescence Signal Amplification by Using β-Galactosidase for Flow Cytometry; Advantages of an Endogenous Activity-free Enzyme,, Anal. Chem., 92, 3069-3076, 2020.01.
16. K. Zai, M. Hirota, T. Yamada, N. Ishihara, T. Mori, A. Kishimura, K. Suzuki, K. Hase, Y. Katayama, Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease, J. Controlled Release, 286, 94-102, 2018.11.
17. K. Sasaki, Y. Miyashita, D. Asai, D. Funamoto, K. Sato, Y. Yamaguchi, Y. Mishima, T. Iino, S. Takaishi, J. Nagano, A. Kishimura, T. Mori, Y. Katayama, A Peptide Inhibitor of Antibody-Dependent Cell-Mediated Cytotoxicity against EGFR/Folate Receptor-α Double Positive Cells, Med. Chem. Commun., 9, 783-788, 2018.03.
18. E. K. Lee, C. W. Kim, H. Kawanami, Akihiro Kishimura, T. Niidome, Takeshi Mori, Yoshiki Katayama, Utilization of a PNA-peptide Conjugate to Induce a Cancer Protease-Responsive RNAi Effect, RSC Adv., 5, 85816, 2015.11, PNA-peptideコンジュゲートにより、腫瘍において選択的にRNAiを生じるシステムを開発した。腫瘍で高活性化しているcathepsin Bを標的にしたシステムであるが、一般性が高く、望みのプロテアーゼに対して設計可能である。.
19. D. Funamoto, D. Asai, K. Sato, Y. Yamaguchi, C. W. Kim, H. Sato, E. Nakhaei, S. Matsumoto, T. Yoshikawa, K. Sasaki, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Antibody Internalization into Living Cell via Crosslinker-mediated Endocytosis, Chem. Lett., 44, 468, 2015.02.
20. K Tobinaga, C Li, M Takeo, T Niidome, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Rapid and serum-insensitive endocytotic delivery of proteins using biotinylated polymers attached via multivalent hydrophobic anchors, J. Controlled Release, 177, 27, 2014.08.
21. M. Matsuda, W. Hatanaka, M. Takeo, C. W. Kim, T. Niidome, T. Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Short Peptide Motifs for Long-Lasting Anchoring to the Cell Surface, Bioconjugate Chem., 25, 2134, 2014.08.
22. GX Zhao, H Tanaka, CW Kim, K Li, D Funamoto, T Nobori, Y Nakamura, T Niidome, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama, Histidinylated poly-L-lysine-based vectors for cancer-specific gene expression via enhancing the endosomal escape, J. Biomater. Sci. Polym. Ed., 25, 519, 2014.07.
23. Takeshi Mori, H. Tang, H. Kobayashi, Y. Niidome, Yoshiki Katayama, T. Niidome, CW/pulsed NIR irradiation of gold nanorods: Effect on transdermal protein delivery mediated by photothermal ablation, J. Controlled Release, 171, 178-183, 2013.10.
24. C. W. Kim, R. Toita, J.-H. Kang, K. Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Nobori, Takeshi Mori, T. Niidome, Y. Nakamura, Yoshiki Katayama, Stabilization of Cancer-specific Gene Carrier via Hydrophobic Interaction for a Clear-cut Response to Cancer Signaling, J. Controlled Release, 170, 469-476, 2013.07.
25. J.-H. Kang, Takeshi Mori, H. Kitazaki, T. Niidome, Y. Nakanishi, K. Takayama, Yoshiki Katayama, Serum protein kinase Cα as a diagnostic biomarker of cancers, Cancer Biomarker, 13, 99-103, 2013.07.
26. H. Ikeda, J. Kamimoto, T. Yamamoto, A. Hata, Y. Otsubo, T. Niidome, M. Fukushima, Takeshi Mori, Yoshiki Katayama, A peptide microarray fabricated on a non-fouling phosphatidylcholine-polymer-coated surface for a high-fidelity analysis of a cellular kinome, Current Med. Chem., 20, 4419-25, 2013.06.
27. Y. Nakamura, C. W. Kim, A. Tsuchiya, S. Kushio, K. Li, T. Nobori, E. K. Lee, G. Xi Zhao, D. Funamoto, T. Niidome, Takeshi Mori, Yoshiki Katayama, Branched polyethylenimine-based PKCα-responsive gene carriers, J. Biomater. Sci.-Polym. Ed., 24, 1858-1868, 2013.06.
28. J.-H. Kang, D. Asai, J.-H. Kim, T. Mori, R. Toita, T. Tomiyama, Y. Asami, J. Oishi, Y. T. Sato, T. Niidome, B. Jun, H. Nakashima, Y. Katayama, Design of polymeric carriers for cancer-specific gene targeting: Utilization of abnormal protein kinase Cα activation in cancer cells, J. Am. Chem. Soc, 130, 14906-14907, 2009.10.
29. T. Mori*, T. Hirano, A. Maruyama, Y. Katayama, T. Niidome, Y. Bnado, K. Ute, S. Takaku, Y. Maeda, Syndiotactic poly(N-n-propylacrylamide) shows highly cooperative phase transition, Langmuir, 25, 48-50, 2009.01.
30. J. Oishi, Y. Asami, T. Mori*, J.-H. Kang, M. Tanabe, T. Niidome, Y. Katayama, Measurement of Homogeneous Kinase Activity for Cell Lysates Based on Aggregation of Gold Nanoparticles, ChemBioChem, 8, 875-879, 2007.06.
31. Measurement of homogeneous kinase activityfor cell lysates based on the aggregation of gold nanoparticles, Measurement of homogeneous kinase activityfor cell lysates based on the aggregation of gold nanoparticles, ChemBioChem, 8, 875-879, , 2007.05.