Kyushu University Academic Staff Educational and Research Activities Database
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Junji Kishimoto Last modified date:2020.07.09

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Academic Degree
Master of Arts in Behavioral Sciences
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
Joint research in various area of medicine as a biostatistician.
CAMIT committee member.
Part-time lecturer of "Multivariate Analysis" and "SAS introduction" at The University of Tokyo.
Chief statistician of clinical trials.
Research Interests
  • Data analysis of PTSD/DV
    keyword : PTSD DV
    1999.04~2006.03Development of enquiry techniques for PTSD or DV..
Current and Past Project
  • Its aim is to improve the health and quality of life of people with diabetes by facilitating concrete initiatives and best practice sharing worldwide to overcome the psychosocial barriers to effective self-management.
  • The antihypertensive effect of the increased dose of angiotensin II receptor blocker (AII antagonist) was compared with that of the additional combined use of amlodipine in hypertensive patients with Type 2 diabetes mellitus, who have been treated with AII antagonist, the antihypertensive effect of which has been inadequate.
  • Japan Prevention Trial of Diabetes by Pitavastatin in Patients with Impaired Glucose Tolerance
Academic Activities
1. Regression Analysis using SAS.
1. Ryuzo Kawamori, Hiroyuki Daida, Yasushi Tanaka, Katsumi Miyauchi, Akira Kitagawa, Dobun Hayashi, Junji Kishimoto, Shunya Ikeda, Yutaka Imai, Tsutomu Yamazaki, Amlodipine versus angiotensin II receptor blocker; control of blood pressure evaluation trial in diabetics (ADVANCED-J), BMC Cardiovascular Disorders, 10.1186/1471-2261-6-39, 6, 2006.10, Background: The coexistence of type 2 diabetes mellitus and hypertension increases the risk of cardiovascular diseases. The U.K. Prospective Diabetes Study has shown that blood pressure control as well as blood glucose control is efficient for prevention of complications in hypertensive patients with diabetes mellitus. However, some reports have shown that it is difficult to control the blood pressure and the concomitant use of a plurality of drugs is needed in hypertensive patients with diabetes mellitus. In recent years renin-angiotensin system depressants are increasingly used for the blood pressure control in diabetic patients. Particularly in Japan, angiotensin II (A II) antagonists are increasingly used. However, there is no definite evidence of the point of which is efficient for the control, the increase in dose of A II antagonist or the concomitant use of another drug, in hypertensive patients whose blood pressure levels are inadequately controlled with A II antagonist. Methods/Design: Hypertensive patients of age 20 years or over with type 2 diabetes mellitus who have been treated by the single use of AII antagonist at usual doses for at least 8 weeks or patients who have been treated by the concomitant use of AII antagonist and an antihypertensive drug other than calcium channel blockers and ACE inhibitors at usual doses for at least 8 weeks are included. Discussion: We designed a multi-center, prospective, randomized, open label, blinded-endpoint trial, ADVANCED-J, to compare the increases in dose of A II antagonist and the concomitant use of a Ca-channel blocker (amlodipine) and A II antagonist in hypertensive patients with diabetes mellitus, whose blood pressure levels were inadequately controlled with A II antagonist. This study is different from the usual previous studies in that home blood pressures are assessed as indicators of evaluation of blood pressure. The ADVANCED-J study may have much influence on selection of antihypertensive drugs for treatment in hypertensive patients with diabetes mellitus. It is expected to give an important hint for considering the validity of selection of anti hypertensive drugs from the aspects not only of the antihypertensive effect but medical cost-effectiveness..
2. Tsuguharu Takahashi, Toru Ogasawara, Junji Kishimoto, Guangyao Liu, Hirotaka Asato, Takashi Nakatsuka, Eijyu Uchinuma, Kozo Nakamura, Hiroshi Kawaguchi, Tsuyoshi Takato, Kazuto Hoshi, Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes, Cell Transplantation, 10.3727/000000005783982675, 14, 9, 683-693, 2005.12, Chondrocyte preparation with the safety and efficiency is the first step in cartilage regenerative medicine. To prepare a chondrocyte proliferation medium that does not contain fetal bovine serum (FBS) and that provides more than a 1000-fold increase in cell numbers within approximately 1 month, we attempted to use the medium containing 5% human serum (HS), but it exerted no more than twofold increase in 2 weeks. To compensate for the limited proliferation ability in HS, we investigated the combinational effects of 12 factors [i.e., fibroblast growth factor(FGF)-2, insulin-like growth factor(IGF)-I, insulin, bone morphogenetic protein-2, parathyroid hormone, growth hormone, dexamethasone, 1α25-dihydroxy vitamin D3, L-3,3′, 5′-triodothyronine, interleukine-1 receptor antagonist, 17β-estradiol, and testosterone] on the proliferation of human auricular chondrocytes by analysis of variance in fractional factorial design. As a result, FGF-2, dexamethasone, insulin, and IGF-I possessed promotional effects on proliferation, while the combination of FGF-2 with insulin or IGF-I synergistically enhanced the proliferation. Actually, the chondrocytes increased 7.5-fold in number in 2 weeks in a medium containing 5% HS with 10 ng/ml FGF-2, while the cell number synergistically gained a 10-12-fold increase with 5 μg/ml insulin or 100 ng/ml IGF-I in the same period. The proliferation effects were more enhanced at a concentration of 100 ng/ml for FGF-2, and especially for the combination of 100 ng/ml FGF-2 and 5 μg/ml insulin (approximately 16-fold within 2 weeks). In the long-term culture with repeated passaging, this combination provided more than 10,000-fold within 8 weeks (i.e., passage 4). Thus, we concluded that such a combination of FGF-2 with insulin or IGF-I may be useful for promotion of auricular chondrocyte proliferation in a clinical application for cartilage regeneration..
3. Keisuke Maruyama, Nobutaka Kawahara, Masahiro Shin, Masao Tago, Junji Kishimoto, Hiroki Kurita, Shunsuke Kawamoto, Akio Morita, Takaaki Kirino, The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations, New England Journal of Medicine, 10.1056/NEJMoa040907, 352, 2, 146-153, 2005.01, BACKGROUND: Angiography shows that stereotactic radiosurgery obliterates most cerebral arteriovenous malformations after a latency period of a few years. However, the effect of this procedure on the risk of hemorrhage is poorly understood. METHODS: We performed a retrospective observational study of 500 patients with malformations who were treated with radiosurgery with use of a gamma knife. The rates of hemorrhage were assessed during three periods: before radiosurgery, between radiosurgery and the angiographic documentation of obliteration of the malformation (latency period), and after angiographic obliteration. RESULTS: Forty-two hemorrhages were documented before radiosurgery (median follow-up, 0.4 year), 23 during the latency period (median follow-up, 2.0 years), and 6 after obliteration (median follow-up, 5.4 years). As compared with the period between diagnosis and radiosurgery, the risk of hemorrhage decreased by 54 percent during the latency period (hazard ratio, 0.46; 95 percent confidence interval, 0.26 to 0.80; P=0.006) and by 88 percent after obliteration (hazard ratio, 0.12; 95 percent confidence interval, 0.05 to 0.29; P<0.001). The risk was significantly reduced during the period after obliteration, as compared with the latency period (hazard ratio, 0.26; 95 percent confidence interval, 0.10 to 0.68; P=0.006). The reduction was greater among patients who presented with hemorrhage than among those without hemorrhage at presentation and similar in analyses that took into account the delay in confirming obliteration by means of angiography and analyses that excluded data obtained during the first year after diagnosis. CONCLUSIONS: Radiosurgery significantly decreases the risk of hemorrhage in patients with cerebral arteriovenous malformations, even before there is angiographic evidence of obliteration. The risk of hemorrhage is further reduced, although not eliminated, after obliteration..
4. Nozomu Asukai, Hiroshi Kato, Noriyuki Kawamura, Yoshiharu Kim, Kohei Yamamoto, Junji Kishimoto, Yuko Miyake, Aya Nishizono-Maher, Reliability and validity of the Japanese-language version of the Impact of Event Scale-Revised (IES-R-J)
Four studies of different traumatic events, Journal of Nervous and Mental Disease, 10.1097/00005053-200203000-00006, 190, 3, 175-182, 2002.04, The authors developed the Japanese-language version of the Impact of Event Scale-Revised (IES-R-J) and investigated its reliability and validity in four different groups: workers with lifetime mixed traumatic events, survivors of an arsenic poisoning case, survivors of the Hanshin-Awaji earthquake, and survivors of the Tokyo Metro sarin attack. Evidence includes retest reliability and internal consistency of the IES-R-J. Posttraumatic stress disorder (PTSD) and partial PTSD cases indicated significantly higher scores than non-PTSD cases. The IES-R-J can be a useful self-rating diagnostic instrument particularly for survivors with PTSD symptoms as a clinical concern (PTSD + partial PTSD) by using a 24/25 cutoff in total score. In analysis of scale structure, the majority of intrusion and hyperarousal items were subsumed under the same cluster, whereas avoidance items made up a separate cluster. Female patients indicated higher scores than male patients. A negative weak correlation between age and the score was found only among female earthquake survivors. The IES-R-J can be used as a validated instrument in future international comparative research..
Membership in Academic Society
  • Japan Statistical Society
  • Japanese Society of Computational Statistics
  • Japanese Society of Applied Statistics
  • Biometric Society of Japan
  • Japan Diabetes Society
  • The Japanese Society of Hypertension
  • The Japanese Society for Child and Adolescent Psychiatry
Educational Activities
Graduate School of Medical Sciences: Analysis of Clinical Research Data.
School of Biomedical Science: Biomedical Seminar II
School of Biomedical Science: Introduction to Biomedical Science II
Graduate School of Systems Life Sciences: Clinical/Medical Engineering.
Part-time lecturer of Biostatistics at the Union of Japanese Scientists and Engineers.
Other Educational Activities
  • 2020.03, Thesis adviser in Graduate School of Nursing, University of Miyazaki.
  • 2006.04, Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers..
  • 2007.04, Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers..
  • 2008.04, Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers..
  • 2009.04, Part-time lecturer of BioStatistics at The Union of Japanese Scientists and Engineers..