Updated on 2025/06/30

Information

 

写真a

 
NAKAO TOMOHIRO
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Professor
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926425640
Profile
精神病態医学分野教授として教室管理を行っている。 精神科神経科科長として病棟・外来の運営・管理を行っている。 精神科領域全般を対象として、入院、外来での臨床活動を行っている。 不安障害、強迫性障害、ためこみ症およびそれらに対する行動療法を主たる専門領域として、臨床および研究活動を行っている。
Homepage
External link

Degree

  • Ph.D.

Research History

  • Kyushu University Faculty of Medical Sciences Department of Clinical Medicine  Professor 

    2007.4 - Present

Research Interests・Research Keywords

  • Research theme: Clinical Training in Obsessive-Compulsive Disorder

    Keyword: Obsessive-compulsive disorder (OCD), hoarding disorder, behavioral therapy, brain neuroimaging, cognitive function

    Research period: 2017.4 - Present

  • Research theme: Clinical research of OCD

    Keyword: OCD, hoarding disorder, Behavior therapy, neuroimaging、cognitive function

    Research period: 2016.4 - 2017.3

  • Research theme: Clinical research of OCD

    Keyword: OCD, hoarding disorder, Behavior therapy, neuroimaging、cognitive function

    Research period: 2016.4 - 2017.3

  • Research theme: Clinical research of OCD

    Keyword: OCD, Behavior therapy, functional neuroimaging

    Research period: 2014.4 - 2015.3

  • Research theme: Clinical research of OCD

    Keyword: OCD, Behavior therapy, functional neuroimaging

    Research period: 2013.4 - 2014.3

  • Research theme: Clinical research of OCD

    Keyword: OCD, Behavior therapy, functional neuroimaging

    Research period: 2012.4 - 2013.3

  • Research theme: Clinical research of Obsessive-compulsive disorder

    Keyword: Obsessive-compulsive disorder (OCD), behavior therapy, functional neuroimaging

    Research period: 2011.4 - 2012.3

  • Research theme: Clinical research of Obsessive-compulsive disorder

    Keyword: Obsessive-compulsive disorder (OCD), behavior therapy, functional neuroimaging

    Research period: 2009.4 - 2010.3

  • Research theme: Clinical research of Obsessive-compulsive disorder

    Keyword: Obsessive-compulsive disorder (OCD), behavior therapy, functional neuroimaging

    Research period: 2009.4 - 2010.3

  • Research theme: Clinical research of Obsessive-compulsive disorder

    Keyword: Obsessive-compulsive disorder (OCD), behavior therapy, functional neuroimaging

    Research period: 2009.4 - 2010.3

  • Research theme: 強迫性障害の臨床研究

    Keyword: 強迫性障害(OCD)、行動療法、機能的脳画像

    Research period: 2007.4 - 2008.3

Papers

  • Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment Reviewed International journal

    Okada Kayo, Tomohiro Nakao, Sanematsu Hirokuni

    Psychiatry Clin Neurosci. 69:411-21, 2015   2015.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment Reviewed International journal

    Tomohiro Nakao

    Psychiatry Clin Neurosci   2014.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Gray Matter Volume Abnormalities in ADHD: Voxel-Based Meta-Analysis Exploring the Effects of Age and Stimulant Medication. Reviewed International journal

    Nakao T, Radua J, Rubia K, Mataix-Cols D

    Am J Psychiatry   2011.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • functional MRI study of brain-activation alterations in patients with obsessive-compulsive disorder after symptom improvement. Reviewed International journal

    Nabeyama M, Nakagawa A, Yoshiura T, Nakao T, Nakatani E, Togao O, Yoshizato C, Yoshioka K, Tomita M, Kanba S

    Psychiatry res neuroimaging   2008.3

     More details

    Publishing type:Research paper (scientific journal)  

  • Duration effect of obsessive-compulsive disorder on cognitive function: a functional MRI study Reviewed International journal

    Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Sanematsu H, Togao O, Yoshioka K, Tomita M, Kuroki T, Kanba S

    Depression and Anxiety   2008.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 強迫性障害の行動療法

    中尾智博

    月刊精神科   2007.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 機能的脳画像と認知機能評価によるOCDの病態解明—SSRIの効果をめぐって—

    中尾智博, 黒木俊秀

    精神神経誌   2007.2

     More details

    Publishing type:Research paper (scientific journal)  

  • 強迫性障害の神経心理機能と治療反応性に罹病期間が与える影響 Reviewed

    中尾智博,中谷江利子,鍋山麻衣子,吉岡和子,富田真弓,中川彰子

    精神神経誌   2005.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task Reviewed International journal

    Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, Kudoh A, Tada K, Yoshioka K, Kawamoto M

    Psychiatry research neuroimaging   139 ( 2 )   101 - 114   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task

    DOI: 10.1016/j.pscychresns.2004.12.004

  • Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement Reviewed International journal

    Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, Kudoh A, Tada K, Yoshioka K, Kawamoto M, Togao O, Kanba S

    Biological psychiatry   57 ( 8 )   901 - 910   2005.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement

    DOI: 10.1016/j.biopsycg.2004.12.039

  • Association of impaired olfactory identification with prevalent mild cognitive impairment and regional brain atrophy: the Hisayama Study

    Minohara, T; Ohara, T; Nakazawa, T; Hirabayashi, N; Furuta, Y; Shibata, M; Hata, J; Kitazono, T; Nakao, T; Ninomiya, T

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   2025.3   ISSN:1323-1316 eISSN:1440-1819

     More details

    Language:English   Publisher:Psychiatry and Clinical Neurosciences  

    Aim: To investigate the association of olfactory identification ability with both the prevalence of mild cognitive impairment (MCI) and regional brain atrophy in a community-dwelling older population. Methods: A total of 1293 participants without dementia aged 65 years or older underwent a Japanese version of the 4-Item Pocket Smell Test, an assessment of cognitive function, and brain magnetic resonance imaging scanning in 2017–2018. Regional gray matter volumes (GMVs) and white matter lesions volume (WMLV) were estimated using FreeSurfer software. The association of impaired olfactory identification with the presence of MCI and regional GMVs or WMLV was estimated by logistic regression analysis and ANCOVA, respectively. We also assessed the association between impaired olfactory identification and GMVs without regions of interest, using a voxel-based morphometry (VBM) analysis. Results: Participants with impaired olfactory identification had a significantly higher likelihood of MCI than those without (odds ratio, 1.99 [95% confidence interval, 1.36–2.91]). In the FreeSurfer analysis, participants with impaired olfactory identification had significantly lower GMVs in the entorhinal cortex, inferior temporal gyrus, amygdala, thalamus, hippocampus, and cingulate gyrus, and higher WMLV than those without. The VBM analysis also showed that impaired olfactory identification was significantly associated with lower volume of the left entorhinal cortex, left amygdala, left hippocampus, bilateral thalami, and bilateral subcallosal areas. Conclusion: Our findings suggest that cognitive function and brain changes may need to be evaluated in older individuals with impaired olfactory identification, which may reflect the extent of neurodegeneration, WMLV, and subsequent cognitive impairment.

    DOI: 10.1111/pcn.13813

    Web of Science

    Scopus

    PubMed

  • A multicenter, single-group, open feasibility study of a new individual cognitive behavioral therapy program for adult Japanese patients with attention-deficit/hyperactivity disorder: Study protocol

    Takamatsu, N; Nakashima, M; Matsuura, K; Umemoto, I; Ito, M; Kanazawa, J; Tomiyama, H; Kondo, M; Tachimori, H; Nakao, T; Horikoshi, M; Kuga, H

    PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS   3 ( 4 )   e70036   2024.12   ISSN:2769-2558

     More details

    Language:English   Publisher:Psychiatry and Clinical Neurosciences Reports  

    Background: Attention-deficit/hyperactivity disorder (ADHD) symptoms, including executive function, emotional regulation, and motivation, can persist into adulthood and are often associated with mental illnesses. Cognitive behavioral therapy (CBT) may help ADHD adults in Japan, but the lack of studies and the variability in group CBT approaches make its effects unclear. Japan lacks unified CBT programs and adult ADHD guidelines, making it difficult to implement international individual CBT recommendations due to cultural differences. This study will assess the feasibility of a novel CBT program for Japanese adult ADHD patients. Methods: This feasibility study will be open, nonrandomized, single-arm, multicenter study. Twelve ADHD patients aged 20–65 years who are currently receiving treatment will be included based on Conners' Adult ADHD Rating Scale (CAARS) clinical severity threshold. An intervention phase of 12–16 weeks and a 12-week follow-up will total 24–28 weeks for all participants. The intervention will use a new CBT program tailored to individual assessments. Results: The primary objective is to determine feasibility using dropout rates, adverse events, and CAARS score changes between Weeks 1 and 16. The secondary outcomes will assess long-term effects of treatment beyond the intervention period and provide descriptive statistics on sex, depression, quality of life, and autistic scores in relation to the intervention outcomes. The full analysis set and per protocol set will be used for statistical analysis. Conclusions: This study is essential for the development of CBT interventions in accordance with Japan's healthcare system that are tailored to the unique needs of its population.

    DOI: 10.1002/pcn5.70036

    Web of Science

    Scopus

    PubMed

  • Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study

    Nakamura, S; Ueda, E; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakazawa, T; Nakao, T; Kitazono, T; Sonoda, KH; Ninomiya, T

    SCIENTIFIC REPORTS   14 ( 1 )   12017   2024.5   ISSN:2045-2322

     More details

    Language:English   Publisher:Scientific Reports  

    We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p < 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19–2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37–2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.

    DOI: 10.1038/s41598-024-62688-7

    Web of Science

    Scopus

    PubMed

  • Aberrant thalamocortical connectivity and shifts between the resting state and task state in patients with schizophrenia

    Takai, Y; Tamura, S; Hoaki, N; Kitajima, K; Nakamura, I; Hirano, S; Ueno, T; Nakao, T; Onitsuka, T; Hirano, Y

    EUROPEAN JOURNAL OF NEUROSCIENCE   59 ( 8 )   1961 - 1976   2024.4   ISSN:0953-816X eISSN:1460-9568

     More details

    Language:English   Publisher:European Journal of Neuroscience  

    Prominent pathological hypotheses for schizophrenia include auditory processing deficits and dysconnectivity within cerebral networks. However, most neuroimaging studies have focused on impairments in either resting-state or task-related functional connectivity in patients with schizophrenia. The aims of our study were to examine (1) blood oxygen level-dependent (BOLD) signals during auditory steady-state response (ASSR) tasks, (2) functional connectivity during the resting-state and ASSR tasks and (3) state shifts between the resting-state and ASSR tasks in patients with schizophrenia. To reduce the functional consequences of scanner noise, we employed resting-state and sparse sampling auditory fMRI paradigms in 25 schizophrenia patients and 25 healthy controls. Auditory stimuli were binaural click trains at frequencies of 20, 30, 40 and 80 Hz. Based on the detected ASSR-evoked BOLD signals, we examined the functional connectivity between the thalamus and bilateral auditory cortex during both the resting state and ASSR task state, as well as their alterations. The schizophrenia group exhibited significantly diminished BOLD signals in the bilateral auditory cortex and thalamus during the 80 Hz ASSR task (corrected p < 0.05). We observed a significant inverse relationship between the resting state and ASSR task state in altered functional connectivity within the thalamo-auditory network in schizophrenia patients. Specifically, our findings demonstrated stronger functional connectivity in the resting state (p < 0.004) and reduced functional connectivity during the ASSR task (p = 0.048), which was mediated by abnormal state shifts, within the schizophrenia group. These results highlight the presence of abnormal thalamocortical connectivity associated with deficits in the shift between resting and task states in patients with schizophrenia.

    DOI: 10.1111/ejn.16298

    Web of Science

    Scopus

    PubMed

  • Abnormal phase entrainment of low- and high-gamma-band auditory steady-state responses in schizophrenia

    Nakanishi, S; Tamura, S; Hirano, S; Takahashi, J; Kitajima, K; Takai, Y; Mitsudo, T; Togao, O; Nakao, T; Onitsuka, T; Hirano, Y

    FRONTIERS IN NEUROSCIENCE   17   1277733   2023.10   ISSN:16624548 eISSN:1662-453X

     More details

    Language:English   Publisher:Frontiers in Neuroscience  

    Introduction: Gamma-band oscillatory deficits have attracted considerable attention as promising biomarkers of schizophrenia (SZ). Notably, a reduced auditory steady-state response (ASSR) in the low gamma band (40 Hz) is widely recognized as a robust finding among SZ patients. However, a comprehensive investigation into the potential utility of the high-gamma-band ASSR in detecting altered neural oscillations in SZ has not yet been conducted. Methods: The present study aimed to assess the ASSR using magnetoencephalography (MEG) data obtained during steady-state stimuli at frequencies of 20, 30, 40, and 80 Hz from 23 SZ patients and 21 healthy controls (HCs). To evaluate the ASSR, we examined the evoked power and phase-locking factor (PLF) in the time-frequency domain for both the primary and secondary auditory cortices. Furthermore, we calculated the phase-locking angle (PLA) to examine oscillatory phase lead or delay in SZ patients. Taking advantage of the high spatial resolution of MEG, we also focused on the hemispheric laterality of low- and high-gamma-band ASSR deficits in SZ. Results: We found abnormal phase delay in the 40 Hz ASSR within the bilateral auditory cortex of SZ patients. Regarding the 80 Hz ASSR, our investigation identified an aberrant phase lead in the left secondary auditory cortex in SZ, accompanied by reduced evoked power in both auditory cortices. Discussion: Given that abnormal phase lead on 80 Hz ASSR exhibited the highest discriminative power between HC and SZ, we propose that the examination of PLA in the 80 Hz ASSR holds significant promise as a robust candidate for identifying neurophysiological endophenotypes associated with SZ. Furthermore, the left-hemisphere phase lead observed in the deficits of 80 Hz PLA aligns with numerous prior studies, which have consistently proposed that SZ is characterized by left-lateralized brain dysfunctions.

    DOI: 10.3389/fnins.2023.1277733

    Web of Science

    Scopus

    PubMed

  • Abnormal phase entrainment of low- and high-gamma-band auditory steady-state responses in schizophrenia

    Nakanishi, S; Tamura, S; Hirano, S; Takahashi, J; Kitajima, K; Takai, Y; Mitsudo, T; Togao, O; Nakao, T; Onitsuka, T; Hirano, Y

    FRONTIERS IN NEUROSCIENCE   2023.10

  • Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease

    Shirozu, N; Ohgidani, M; Hata, N; Tanaka, S; Inamine, S; Sagata, N; Kimura, T; Inoue, I; Arimura, K; Nakamizo, A; Nishimura, A; Maehara, N; Takagishi, S; Iwaki, K; Nakao, T; Masuda, K; Sakai, Y; Mizoguchi, M; Yoshimoto, K; Kato, TA

    SCIENTIFIC REPORTS   13 ( 1 )   14842   2023.9   ISSN:2045-2322

     More details

    Language:English   Publisher:Scientific Reports  

    Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2 polarized microglia in ischemic stroke, suggesting that microglia may be involved in the pathophysiology of MMD; however, existing approaches are not applicable to explore this hypothesis. Herein we applied blood induced microglial-like (iMG) cells. We recruited 25 adult patients with MMD and 24 healthy volunteers. Patients with MMD were subdivided into progressive (N = 7) or stable (N = 18) group whether novel symptoms or radiographic advancement of Suzuki stage within 1 year was observed or not. We produced 3 types of iMG cells; resting, M1-, and M2-induced cells from monocytes, then RNA sequencing followed by GO and KEGG pathway enrichment analysis and qPCR assay were performed. RNA sequencing of M2-induced iMG cells revealed that 600 genes were significantly upregulated (338) or downregulated (262) in patients with MMD. Inflammation and immune-related factors and angiogenesis-related factors were specifically associated with MMD in GO analysis. qPCR for MMP9, VEGFA, and TGFB1 expression validated these findings. This study is the first to demonstrate that M2 microglia may be involved in the angiogenic process of MMD. The iMG technique provides a promising approach to explore the bioactivity of microglia in cerebrovascular diseases.

    DOI: 10.1038/s41598-023-41456-z

    Web of Science

    Scopus

    PubMed

  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study

    Tajimi, T; Furuta, Y; Hirabayashi, N; Honda, T; Hata, J; Ohara, T; Shibata, M; Nakao, T; Kitazono, T; Nakashima, Y; Ninomiya, T

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   106   104883   2023.3   ISSN:0167-4943 eISSN:1872-6976

     More details

    Language:English   Publisher:Archives of Gerontology and Geriatrics  

    Background: To investigate the association of gait speed with regional brain volumes and the risk of incident dementia. Methods: A total of 1112 dementia-free Japanese residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years (median). The participants were classified into the age- and sex-specific quartile levels of maximum gait speed. Regional gray matter volumes (GMV) and white matter hyperintensities volumes (WMHV) were measured by applying voxel-based morphometry methods. The cross-sectional association of maximum gait speed with regional GMV was examined using an analysis of covariance. We also estimated the association between maximum gait speed level and the risk of developing dementia using a Cox proportional hazards model. Mediation analyses were conducted to determine the contribution of regional brain volumes to the association between maximum gait speed and dementia. Results: Lower maximum gait speed was significantly associated with lower GMV of the total brain, frontal lobe, temporal lobe, cingulate gyrus, insula, hippocampus, amygdala, basal ganglia, thalamus, and cerebellum, and increased WMHV at baseline. During the follow-up, 108 participants developed dementia. The incidence rate of all dementias increased significantly with decreasing maximum gait speed after adjusting for potential confounders (P for trend = 0.03). The mediating effects of the GMV of the hippocampus, GMV of the insula, and WMHV were significant. Conclusions: Lower maximum gait speed was significantly associated with an increased risk of dementia. Reduced GMV of the hippocampus or insula, and an increase in WMHV was likely to be involved in this association.

    DOI: 10.1016/j.archger.2022.104883

    Web of Science

    Scopus

    PubMed

  • A case of bipolar disorder with <i>AIF1</i> (coding gene of Iba-1) deletion: A pilot <i>in vitro</i> analysis using blood-derived microglia-like cells

    Ohgidani, M; Kushima, I; Inamine, S; Kyuragi, S; Sagata, N; Nakao, T; Kanba, S; Ozaki, N; Kato, TA

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   77 ( 2 )   128 - 130   2023.2   ISSN:1323-1316 eISSN:1440-1819

     More details

    Language:English   Publisher:Psychiatry and Clinical Neurosciences  

    DOI: 10.1111/pcn.13505

    Web of Science

    Scopus

    PubMed

  • 3-day intervention program for family members of hikikomori sufferers: A pilot randomized controlled trial

    Kubo, H; Urata, H; Sakai, M; Nonaka, S; Kishimoto, J; Saito, K; Tateno, M; Kobara, K; Fujisawa, D; Hashimoto, N; Suzuki, Y; Honda, Y; Nakao, T; Otsuka, K; Kanba, S; Kuroki, T; Kato, TA

    FRONTIERS IN PSYCHIATRY   13   1029653   2023.1   ISSN:1664-0640

     More details

    Language:English   Publisher:Frontiers in Psychiatry  

    Backgrounds: Hikikomori, pathological social withdrawal, is becoming a crucial mental health issue in Japan and worldwide. We have developed a 3-day family intervention program for hikikomori sufferers based on Mental Health First Aid (MHFA) and Community Reinforcement and Family Training (CRAFT). This study aims to confirm the effectiveness of the 3-day program by a randomized controlled trial. Methods: This study was registered on the UMIN Clinical Trials Registry (UMIN000037289). Fifteen parents were assigned to the treat as usual (TAU) group (TAU only; Age Mean, 65.6; SD, 7.8), and 14 to the Program group (program + TAU; Age Mean, 67.9; SD, 8.6). This study was discontinued due to the COVID-19 pandemic; the recruitment rate was 36.3% of our target sample size of 80. Results: Perceived skills improved temporally and stigma temporally worsened in the TAU group. Confidence decreased and attitude showed no change in both groups. Aggressive behaviors of hikikomori sufferers were significantly worsened in the Program group; however, no serious domestic violence was reported. In the TAU group, Avoidance and irregular life patterns were improved. Activity levels were worsened in both groups. Two participants (16.7%) in the Program group and one participant (7.7%) in the TAU group reported actual behavioral changes (e.g., utilizing support). Conclusion: We could not draw general conclusions on the effectiveness of the program due to the study discontinuation. Nevertheless, this study indicates the necessity for revision of the program to improve family members’ confidence in engaging with hikikomori sufferers, with safer approaching by families.

    DOI: 10.3389/fpsyt.2022.1029653

    Web of Science

    Scopus

    PubMed

  • Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder

    Tomiyama, H; Murayama, K; Nemoto, K; Hasuzawa, S; Mizobe, T; Kato, K; Matsuo, A; Ohno, A; Kang, M; Togao, O; Hiwatashi, A; Ishigami, K; Nakao, T

    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY   116   110516   2022.6   ISSN:0278-5846 eISSN:1878-4216

     More details

    Language:English   Publisher:Progress in Neuro Psychopharmacology and Biological Psychiatry  

    Background It is gradually becoming clear that obsessive-compulsive disorder (OCD) patients have aberrant resting-state large-scale intrinsic networks of cingulo-opercular salience (SN), default mode (DMN), and front-parietal network (FPN). However, it remains unknown whether unaffected first-degree relatives of OCD patients have these alterations as a vulnerability marker to the disorder. Methods We performed resting-state functional magnetic resonance imaging (rsfMRI) scans of 47 medication-free OCD patients, 21 unaffected healthy first-degree relatives of OCD patients, and 62 healthy control (HC) participants. We explored differences between the three groups in the functional connectivity from SN (seeds: anterior-insula (AI) and dorsal anterior cingulate cortex (dACC)), DMN (seeds: medial prefrontal cortex (MPFC) and posterior parietal cortex (PCC)), and FPN (seeds: dorsolateral prefrontal cortex (DLPFC)). Results Compared to HC, both OCD patients and first-degree relatives showed significantly greater functional connectivity between AI and PCC and between DLPFC and the thalamus. Compared to first-degree relatives and HC, OCD patients showed reduced functional connectivity between PCC and DLPFC, and this altered functional connectivity was negatively correlated with anxiety and depressive symptom within OCD group. Conclusions OCD patients and unaffected first-degree relatives of OCD patients showed overlapping alterations in resting state functional connectivity between the regions of SN and DMN and between DLPFC and the thalamus. Our results suggested that alterations between large-scale intrinsic networks and within the dorsal cognitive cortico-striato-thalamo-cortical (CSTC) circuit could represent endophenotype markers of OCD.

    DOI: 10.1016/j.pnpbp.2022.110516

    Web of Science

    Scopus

    PubMed

  • Abnormal white matter structure in hoarding disorder

    Mizobe, T; Ikari, K; Tomiyama, H; Murayama, K; Kato, K; Hasuzawa, S; Togao, O; Hiwatashi, A; Nakao, T

    JOURNAL OF PSYCHIATRIC RESEARCH   148   1 - 8   2022.4   ISSN:0022-3956 eISSN:1879-1379

     More details

    Language:English   Publisher:Journal of Psychiatric Research  

    Although preliminary neuroimaging research suggests that patients with hoarding disorder (HD) show widespread abnormal task-related activity in the brain, there has been no research on alterations in the white matter tracts in these patients. The aim of this study was to investigate the characteristics of the major white matter tracts in patients with HD. Tract-based spatial statistics were used to search for white matter tract abnormalities throughout the brain in 25 patients with HD and 36 healthy controls. Post hoc analysis of regions of interest was performed to detect correlations with clinical features. Compared with the controls, patients with HD showed decreased fractional anisotropy and increased radial diffusivity in anatomically widespread white matter tracts. Post hoc analysis of regions of interest revealed a significant negative correlation between the severity of hoarding symptoms and fractional anisotropy in the left anterior limb of the internal capsule and a positive correlation between the severity of these symptoms and radial diffusivity in the right anterior thalamic radiation. Patients with HD showed a broad range of alterations in the frontal white matter tracts, including the frontothalamic circuit, frontoparietal network, and frontolimbic pathway. The findings of this study indicate associations between frontal white matter abnormalities related to the severity of hoarding symptoms in HD and the cortical regions involved in cognitive dysfunction. The insights provided would be useful for understanding the neurobiological basis of HD.

    DOI: 10.1016/j.jpsychires.2022.01.031

    Web of Science

    Scopus

    PubMed

  • Abnormal white matter structure in hoarding disorder

    Mizobe, T; Ikari, K; Tomiyama, H; Murayama, K; Kato, K; Hasuzawa, S; Togao, O; Hiwatashi, A; Nakao, T

    JOURNAL OF PSYCHIATRIC RESEARCH   2022.4

     More details

    Authorship:Last author  

  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community

    Ohara, T; Hata, J; Tanaka, M; Honda, T; Yamakage, H; Inoue, T; Hirakawa, Y; Kusakabe, T; Shibata, M; Kitazono, T; Nakao, T; Satoh-Asahara, N; Ninomiya, T

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   70 ( 4 )   1147 - 1156   2022.4   ISSN:0002-8614 eISSN:1532-5415

     More details

    Language:English   Publisher:Journal of the American Geriatrics Society  

    Background: Little is known about the influence of serum level of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is a soluble type of an innate immune receptor expressed on the microglia, on the association of the daily sleep duration with the risk of dementia. Methods: A total of 1230 Japanese community-residents aged 60 and older without dementia were followed prospectively for 10 years (2002–2012). Serum sTREM2 levels were divided into two groups using the median value (334.8 pg/ml). Self-reported daily sleep duration was grouped into three categories of <5.0, 5.0–7.9, and ≥8.0 h. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of daily sleep duration on the risk of dementia according to serum sTREM2 levels. Results: During the follow-up, 262 subjects developed dementia. In subjects with low serum sTREM2 levels, subjects with ≥8.0 h of daily sleep had a significantly greater risk of dementia (multivariable-adjusted HR 2.05 [95% CI 1.32–3.19]) than those with 5.0–7.9 h of daily sleep, but those with <5.0 h did not. In contrast, the risk of dementia increased significantly in subjects with both <5.0 (1.95 [1.03–3.68]) and ≥8.0 h of daily sleep (1.48 [1.06–2.07]) in the subjects with high serum sTREM2 levels. Conclusions: The influence of daily sleep duration on risk of dementia differed according to serum sTREM2 levels in the older Japanese population. Short daily sleep may be associated with greater risk of dementia only in subjects with a high serum sTREM2 level.

    DOI: 10.1111/jgs.17634

    Web of Science

    Scopus

    PubMed

  • Clinical characteristics of hoarding disorder in Japanese patients Reviewed

    Masumi Kuwano, Tomohiro Nakao, Koji Yonemoto, Satoshi Yamada, Keitaro Murayama, Kayo Okada, Shinichi Honda, Keisuke Ikari, Hirofumi Tomiyama, Suguru Hasuzawa, Shigenobu Kanba

    Heliyon   6 ( 3 )   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Previous studies have reported clinical characteristics of hoarding disorder (HD), such as early onset, a chronic course, familiality, high unmarried rate, and high rates of comorbidities. However, clinical research targeting Japanese HD patients has been very limited. As a result, there is a low recognition of HD in Japan, leading to insufficient evaluation and treatment of Japanese HD patients. The aim of the current study was to delineate the clinical characteristics of Japanese HD patients. Thirty HD patients, 20 obsessive-compulsive disorder (OCD) patients, and 21 normal controls (NC) were targeted in this study. The HD group had a tendency toward higher familiality, earlier onset, and longer disease duration compared to the OCD group. In addition, the HD group showed a significantly higher unmarried rate than the NC group. The top two comorbidities in the HD group were major depressive disorder (56.7%) and attention-deficit/hyperactivity disorder (26.7%). The HD group had significantly higher scores on hoarding rating scales and lower scores on the Global Assessment of Functioning Scale than the other two groups. The current study showed a clinical trend in Japanese HD patients similar to previous studies in various countries, suggesting that HD may be a universal disease with consistent clinical symptoms.

    DOI: 10.1016/j.heliyon.2020.e03527

  • Brain structural covariance networks in obsessive-compulsive disorder A graph analysis from the ENIGMA consortium Reviewed

    , Je Yeon Yun, Premika S.W. Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Jean Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O’Neill, John Piacentini, Fabrizio Piras, Federica Piras

    Brain   143 ( 2 )   684 - 700   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10–0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P 5 0.0001), lower modularity (P 5 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions.

    DOI: 10.1093/brain/awaa001

  • Pathophysiology and treatment of hoarding disorder Reviewed

    Tomohiro Nakao, Shigenobu Kanba

    Psychiatry and clinical neurosciences   73 ( 7 )   370 - 375   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Hoarding disorder (HD) is a newly listed disease in the new category of Obsessive–Compulsive and Related Disorders in the DSM-5. Patients with HD find it difficult to discard possessions regardless of their actual value and to organize those things. As a result, the possessions overflow the living space and hinder living functions. Though the hoarding symptom had been regarded as a subtype of obsessive–compulsive disorder (OCD) to date, recent studies have revealed many differences in clinical characteristics, including onset, course, degree of insight, and treatment responses, between hoarding and other subtypes. Moreover, several neuroimaging studies have found specific changes of brain structure and function in OCD patients with hoarding symptoms compared to patients with non-hoarding OCD. Meanwhile, strategies for treatment of HD have not been standardized. At present, psychological treatment using cognitive behavioral therapy techniques has a certain effect. In this review, we outline the pathophysiology and treatment of HD.

    DOI: 10.1111/pcn.12853

  • Relevance of hoarding behavior and the traits of developmental disorders among university students A self-reported assessment study Reviewed

    Kosuke Kajitani, Rikako Tsuchimoto, Jun Nagano, Tomohiro Nakao

    BioPsychoSocial Medicine   13 ( 1 )   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: Previous studies have shown that hoarding behavior usually starts at a subclinical level in early adolescence and gradually worsens; however, a limited number of studies have examined the prevalence of hoarding behavior and its association with developmental disorders in young adults. The aims of this study were to estimate the prevalence of hoarding behavior and to identify correlations between hoarding behavior and developmental disorder traits in university students. Methods: The study participants included 801 university students (616 men, 185 women) who completed questionnaires (ASRS: Adult ADHD Self-Report Scale version 1.1, AQ16: Autism-Spectrum Quotient with 16 items, and CIR: Clutter Image Rating). Results: Among 801 participants, 27 (3.4%) exceeded the CIR cut-off score. Moreover, the participants with hoarding behavior had a significantly higher percentage of ADHD traits compared to participants without hoarding behavior (HB(+) vs HB(-), 40.7% vs 21.7%). In addition, 7.4% of HB(+) participants had autism spectrum disorder (ASD) traits, compared to 4.1% of HB(-) participants. A correlation analysis revealed that the CIR composite score had a stronger correlation with the ASRS inattentive score than with the hyperactivity/impulsivity score (CIR composite vs ASRS IA, r = 0.283; CIR composite vs ASRS H/I, r = 0.147). Conclusions: The results showed a high prevalence of ADHD traits in the university students with hoarding behavior. Moreover, we found that the hoarding behavior was more strongly correlated with inattentive symptoms rather than with hyperactivity/impulsivity symptoms. Our results support the concept of a common pathophysiology behind hoarding behavior and ADHD in young adults.

    DOI: 10.1186/s13030-019-0156-1

  • Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder A resting-state fMRI study Reviewed

    Hirofumi Tomiyama, Tomohiro Nakao, Keitaro Murayama, Kiyotaka Nemoto, Keisuke Ikari, Satoshi Yamada, Masumi Kuwano, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi, Shigenobu Kanba

    NeuroImage: Clinical   24   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: Impaired cognitive flexibility has been implicated in the genetic basis of obsessive-compulsive disorder (OCD). Recent endophenotype studies of OCD showed neural inefficiency in the cognitive control network and interference by the limbic network of the cognitive control network. Exploring the relationship between the functional brain network and impaired cognitive flexibility may provide novel information about the neurobiological basis of OCD. Methods: We obtained resting-state functional magnetic resonance imaging (rsfMRI) scans and measured the cognitive flexibility of 37 medication-free OCD patients and 40 healthy control (HC) participants using the Wisconsin Card Sorting Test (WCST). We explored the difference between OCD and HC groups in the functional brain network related to impaired cognitive flexibility from the amygdala and dorsal striatal regions of interest (ROIs) by using a seed-based approach. Results: Significant differences between the OCD and HC groups were identified in the resting state functional network from the dorsal caudate. Increased functional connectivity from the dorsal caudate to the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) was associated with poorer cognitive flexibility in the OCD group, but better cognitive flexibility in the HC group. Conclusions: These results provide evidence that the impaired cognitive flexibility of OCD may be associated with dysfunctions of the brain network from the dorsal caudate (DC) to important nodes of the salience network. Our results extend the neuropsychological model of OCD by showing intrinsically different associations between OCD and HC in functional network and cognitive flexibility.

    DOI: 10.1016/j.nicl.2019.102004

  • Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder Findings From the ENIGMA Consortium Reviewed

    , Xiang Zhen Kong, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A. Ely, Jamie Feusner, Kate D. Fitzgerald, Jean Paul Fouche, Egill A. Fridgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gürsel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Sarah E. Medland

    Biological Psychiatry   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

    DOI: 10.1016/j.biopsych.2019.04.022

  • A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder Reviewed

    Satoshi Yamada, Tomohiro Nakao, Keisuke Ikari, Masumi Kuwano, Keitaro Murayama, Hirofumi Tomiyama, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi, Shigenobu Kanba

    PloS one   13 ( 7 )   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. Methods Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. Results The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p<0.05) in both Brodmann area (BA)10 and BA11. There was no significant difference between OCD and healthy control groups. No significant correlation between the clinical data including age of onset, symptom severity score, and GM volume was observed in HD and OCD groups. Conclusions The results might help to explain the inconsistency of previous studies. As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD.

    DOI: 10.1371/journal.pone.0200814

  • Cortical abnormalities associated with pediatric and adult obsessive-compulsive disorder Findings from the enigma obsessive-compulsive disorder working group Reviewed

    Premika S.W. Boedhoe, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Kate D. Fitzgerald, Jean Paul Fouche, Egill A. Fridgeirsson, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Neda Jahanshad, Anthony James, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Astrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Seiji Nishida, Erika Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y. C.Janardhan Reddy, Tim J. Reess, Yuki Sakai, Joao R. Sato, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Guido A. Van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Je Yeon Yun, Paul M. Thompson, Dan J. Stein, Odile A. Van Den Heuvel

    American Journal of Psychiatry   175 ( 5 )   453 - 462   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Objective: Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken. Method: T1-weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume. Results: In adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortexand a thinner inferiorparietalcortex.Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showedsignificant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from 20.10 to 20.33. Conclusions: The parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.

    DOI: 10.1176/appi.ajp.2017.17050485

  • A transcultural study of hoarding disorder Insights from the United Kingdom, Spain, Japan, and Brazil Reviewed

    Ashley E. Nordsletten, Lorena Fernández de la Cruz, Elena Aluco, Pino Alonso, Clara López-Solà, José M. Menchón, Tomohiro Nakao, Masumi Kuwano, Satoshi Yamada, Leonardo F. Fontenelle, André Luís Campos-Lima, David Mataix-Cols

    Transcultural Psychiatry   55 ( 2 )   261 - 285   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Though problematic hoarding is believed to be a universal human behavior, investigations of clinically-defined hoarding disorder (HD) have been confined almost exclusively to Western countries. The current investigation sought to describe and directly compare the features of individuals meeting diagnostic criteria for HD across four distinct cultural settings. Participants were 82 individuals meeting DSM-5 diagnostic criteria for HD, recruited and assessed by trained clinicians at one of four project sites: London, Barcelona, Fukuoka, and Rio de Janeiro. A series of semi-structured interviews and self-report scales were administered, including assessments of socio-demographic characteristics, psychiatric comorbidity, and severity of hoarding and related features. Results indicate that the severity and core features of HD, as well as the cognitions and behaviors commonly associated with this condition, are largely stable across cultures. However, some differences in patient demographics—in particular age, marital status, and clinical expression—as well as comorbid psychiatric features also emerged. These findings confirm that HD, as defined in DSM-5, exists and presents with similar phenomenology across the studied cultures. Future, more fine-grained, research will be needed to study the features of the disorder in additional cultures (e.g., non-industrialized nations) and to evaluate the impact of these cultural aspects on the design of interventions for the disorder.

    DOI: 10.1177/1363461518759203

  • Corrigendum to “Morphologic and clinical differences between early- and late-onset obsessive-compulsive disorder Voxel-based morphometric study” (Journal of Obsessive-Compulsive and Related Disorders (2017) (35–41)(S2211364916301580)(10.1016/j.jocrd.2017.02.005)) Reviewed

    Keisuke Ikari, Tomohiro Nakao, Kiyotaka Nemoto, Kayo Okada, Keitaro Murayama, Shinichi Honda, Masumi Kuwano, Satoshi Yamada, Hirofumi Tomiyama, Mayumi Tomita, Osamu Togao, Akio Hiwatashi, Shigenobu Kanba

    Journal of Obsessive-Compulsive and Related Disorders   16   112 - 113   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    We regret that Table 1 and Fig. 2 need correction. As for Table 1, we found a few critical errors. The patients' age is not 18–64 years old, correctly 17–64 years old. The patients' age of onset is not 4–38 years old, correctly 6–54 years old. The patients' duration of illness is not 0.6–42 years, correctly 0.6–51 years. As for Fig.2, several readers pointed us that it was difficult to see. So we would like to make corrections. We coloured the lines to make it distinguishable, and enlarged letters to make it more visible. We explained in footnote which line colour corresponds to which group. We attached the modified files. We are sorry to trouble you, but we hope that you will correct and replace them by the following files. We would like to apologise for any inconvenience caused.

    DOI: 10.1016/j.jocrd.2017.11.005

  • Morphologic and clinical differences between Early- and Late-onset obsessive-compulsive disorder: Voxel-Based Morphometric study Reviewed International journal

    Keisuke Ikari, Tomohiro Nakao, Keitaro Murayama

    Journal of Obsessive-Compulsive and Related Disorders   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients Reviewed International journal

    Shinichi Honda, Tomohiro Nakao, Keitaro Murayama

    Annals of General Psychiatry   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • DSM-5の強迫関連症群の概要と臨床的意義—ためこみ症を中心に— Invited Reviewed

    中尾智博

    精神科治療学   2017.3

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Biological heterogeneity of obsessive-compulsive disorder A voxel-based morphometric study based on dimensional assessment Reviewed

    Kayo Okada, Tomohiro Nakao, Hirokuni Sanematsu, Keitaro Murayama, Shinichi Honda, Mayumi Tomita, Osamu Togao, Takashi Yoshiura, Shigenobu Kanba

    Psychiatry and Clinical Neurosciences   69 ( 7 )   411 - 421   2015.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Aim Although many neuroimaging studies of obsessive-compulsive disorder (OCD) have reported broad abnormalities in gray matter (GM), their results remain inconsistent. One reason for this inconsistency could be the heterogeneity of OCD. In the present study, we aimed to classify alterations in brain anatomy by OCD subtype. Methods Magnetic resonance imaging examinations of 37 OCD patients and 37 matched healthy controls were conducted using a 3.0-Tesla scanner. In the voxel-based morphometric procedure, preprocessed GM structural images were used to compare the two groups, and multiple regression analysis was used to investigate the correlation between regional GM volume in OCD patients and the OCD symptom dimension type assessed by using the Dimensional Yale-Brown Obsessive-Compulsive Scale. Results We found significant reductions in GM volume in broad areas of the left prefrontal, right orbitofrontal, right parietal, right temporal, and right posterior cingulate cortex in the OCD patients compared to healthy controls. In addition, we found specific negative correlations between symptomatic dimension scores and regional GM volumes, mainly as decreased right cerebellum in 'aggression/checking' and decreased right insula in 'contamination/washing'. Conclusion The pathophysiology of OCD may involve widely distributed neural systems. Moreover, there are distinct correlations among symptomatic dimensions and structural abnormalities.

    DOI: 10.1111/pcn.12269

  • Behavioral Activation for Depression Theory and Practice Reviewed

    Tomohiro Nakao

    Psychiatria et Neurologia Japonica - Seishin Shinkeigaku Zasshi   117 ( 1 )   18 - 25   2015.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Behavioral activation (BA) has recently attracted marked attention. While cognitive therapy focuses on the cognitive distortion of patients with depression and asks them to change their behaviors as the process of altering the cognitive distortion, BA pays attention to behavior to avoid an unpleasant situation or social situation as a key symptom that leads to persistence of the depression. Avoidance behaviors are often seen during every process of depression, from onset to recurrence. Avoidance behaviors, a decrease in pleasant phenomena, or increase in unpleasant phenomena, result in reinforcing a depressive mood. If patients can set appropriate behavioral targets and achieve them, the beneficial behaviors will be further promoted with positive feed-back. The behavioral change, as-a consequence, will result in improvement of the mood, cognition, and depression itself. In this manuscript, the author presents two clinical cases, in which BA assisted the patients in recovering from their depression. The first case was a male in his thirties who repeatedly took sick leave from his work because of maladjustment, which resulted in persistent depression. The second case was a female in her thirties who suffered from OCD and then became maladjusted to her place of work, depressive, and emotionally unstable. In both cases, avoidant behaviors caused their conditions to persist. Appropriate activities formed by BA improved their moods, and their self-efficacies were gradually regained. It was suggested that BA is markedly effective, especially in patients whose avoidant behaviors mainly cause the persistence of their depressive symptoms.

  • Neural bases of antisocial behavior A voxel-based meta-analysis Reviewed

    Yuta Aoki, Ryota Inokuchi, Tomohiro Nakao, Hidenori Yamasue

    Social Cognitive and Affective Neuroscience   9 ( 8 )   1223 - 1231   2014.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Individuals with antisocial behavior place a great physical and economic burden on society. Deficits in emotional processing have been recognized as a fundamental cause of antisocial behavior. Emerging evidence also highlights a significant contribution of attention allocation deficits to such behavior. A comprehensive literature search identified 12 studies that were eligible for inclusion in the meta-analysis, which compared 291 individuals with antisocial problems and 247 controls. Signed Differential Mapping revealed that compared with controls, gray matter volume (GMV) in subjects with antisocial behavior was reduced in the right lentiform nucleus (P < 0.0001), left insula (P=0.0002) and left frontopolar cortex (FPC) (P=0.0006), and was increased in the right fusiform gyrus (P < 0.0001), right inferior parietal lobule (P=0.0003), right superior parietal lobule (P=0.0004), right cingulate gyrus (P=0.0004) and the right postcentral gyrus (P=0.0004). Given the well-known contributions of limbic and paralimbic areas to emotional processing, the observed reductions in GMV in these regions might represent neural correlates of disturbance in emotional processing underlying antisocial behavior. Previous studies have suggested an FPC role in attention allocation during emotional processing. Therefore, GMV deviations in this area may constitute a neural basis of deficits in attention allocation linked with antisocial behavior.

    DOI: 10.1093/scan/nst104

  • Neural bases of antisocial behavior a voxel-based meta-analysis Reviewed

    Yuta Aoki, Ryota Inokuchi, Tomohiro Nakao, Hidenori Yamasue

    Social Cognitive and Affective Neuroscience   9 ( 8 )   1223 - 1231   2014.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Individuals with antisocial behavior place a great physical and economic burden on society. Deficits in emotional processing have been recognized as a fundamental cause of antisocial behavior. Emerging evidence also highlights a significant contribution of attention allocation deficits to such behavior. A comprehensive literature search identified 12 studies that were eligible for inclusion in the meta-analysis, which compared 291 individuals with antisocial problems and 247 controls. Signed Differential Mapping revealed that compared with controls, gray matter volume (GMV) in subjects with antisocial behavior was reduced in the right lentiform nucleus (P < 0.0001), left insula (P = 0.0002) and left frontopolar cortex (FPC) (P = 0.0006), and was increased in the right fusiform gyrus (P < 0.0001), right inferior parietal lobule (P = 0.0003), right superior parietal lobule (P = 0.0004), right cingulate gyrus (P = 0.0004) and the right postcentral gyrus (P = 0.0004). Given the well-known contributions of limbic and paralimbic areas to emotional processing, the observed reductions in GMV in these regions might represent neural correlates of disturbance in emotional processing underlying antisocial behavior. Previous studies have suggested an FPC role in attention allocation during emotional processing. Therefore, GMV deviations in this area may constitute a neural basis of deficits in attention allocation linked with antisocial behavior.

    DOI: 10.1093/scan/nst104

  • Neurobiological model of obsessive-compulsive disorder Evidence from recent neuropsychological and neuroimaging findings Reviewed

    Tomohiro Nakao, Kayo Okada, Shigenobu Kanba

    Psychiatry and Clinical Neurosciences   68 ( 8 )   587 - 605   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Obsessive-compulsive disorder (OCD) was previously considered refractory to most types of therapeutic intervention. There is now, however, ample evidence that selective serotonin reuptake inhibitors and behavior therapy are highly effective methods for treatment of OCD. Furthermore, recent neurobiological studies of OCD have found a close correlation between clinical symptoms, cognitive function, and brain function. A large number of previous neuroimaging studies using positron emission tomography, single-photon emission computed tomography or functional magnetic resonance imaging (fMRI) have identified abnormally high activities throughout the frontal cortex and subcortical structures in patients with OCD. Most studies reported excessive activation of these areas during symptom provocation. Furthermore, these hyperactivities were decreased after successful treatment using either selective serotonin reuptake inhibitors or behavioral therapy. Based on these findings, an orbitofronto-striatal model has been postulated as an abnormal neural circuit that mediates symptomatic expression of OCD. On the other hand, previous neuropsychological studies of OCD have reported cognitive dysfunction in executive function, attention, nonverbal memory, and visuospatial skills. Moreover, recent fMRI studies have revealed a correlation between neuropsychological dysfunction and clinical symptoms in OCD by using neuropsychological tasks during fMRI. The evidence from fMRI studies suggests that broader regions, including dorsolateral prefrontal and posterior regions, might be involved in the pathophysiology of OCD. Further, we should consider that OCD is heterogeneous and might have several different neural systems related to clinical factors, such as symptom dimensions. This review outlines recent neuropsychological and neuroimaging studies of OCD. We will also describe several neurobiological models that have been developed recently. Advanced findings in these fields will update the conventional biological model of OCD.

    DOI: 10.1111/pcn.12195

  • Erratum to "fMRI of patients with social anxiety disorder during a social situation task" [Neuroscience Research 69 (2011) 67-72] Reviewed

    Tomohiro Nakao, Hirokuni Sanematsu, Takashi Yoshiura, Osamu Togao, Keitaro Murayama, Mayumi Tomita, Yusuke Masuda, Shigenobu Kanba

    Neuroscience Research   81-82   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2010.12.008

  • [Treatment-refractory OCD and its biological pathophysiology]. Reviewed

    Tomohiro Nakao

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica   115 ( 9 )   981 - 989   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Recently, ample evidence has suggested that selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy are highly effective treatments for OCD. There are, however, certain patients who are refractory to almost all types of therapeutic intervention. In recent studies, atypical antipsychotic augmentation of SSRIs and deep brain stimulation have been suggested to be effective for these refractory-type patients. Dysfunction of neuro-circuits throughout the frontal cortex and associated subcortical structures is considered to be due to both serotonergic and dopaminergic nerve system impairment. A large number of previous neuroimaging studies identified abnormally high metabolic activities throughout the frontal cortex as well as subcortical and limbic structures. These over-activities are suggested to be biological markers of the treatment response. In addition, structural and nerve connective dysfunction of these regions may be associated with a severe, treatment-resistant, and treatment-refractory status. A treatment-refractory state may be attributable to the clinical subtypes of OCD. Associations between the symptom subtype and brain activity reveal the heterogeneity of OCD. Several correlative analyses have shown distinct neural correlations associated with specific OCD symptom dimensions such as aggression/checking, contamination/cleaning, and hoarding. Overlapping of these neural disturbances will cause treatment-refractory OCD. Another reason for a treatment-refractory state may be comorbid disorders such as major depression and tic disorders. Comorbid depression will aggravate metabolic impairments in the hippocampus and thalamus and cause more severe disturbance of neuro-circuits in OCD. Obsessive-compulsive symptom with Tourette syndrome or pervasive developmental disorders will become refractory because of fixation caused by developmental factors and a perceptual element called "just right feeling". There should be a close relationship between neuro-circuit disturbance and a treatment-refractory state. The pathophysiology becomes more complicated due to the symptom subtype and comorbidity. Further investigations are needed to develop effective treatment strategies based on biological evidence.

  • Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder Reviewed

    Keitaro Murayama, Tomohiro Nakao, Hirokuni Sanematsu, Kayo Okada, Takashi Yoshiura, Mayumi Tomita, Yusuke Masuda, Kayoko Isomura, Akiko Nakagawa, Shigenobu Kanba

    Progress in Neuro-Psychopharmacology and Biological Psychiatry   40 ( 1 )   160 - 166   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The aim of this study was to investigate differential neural responses to a symptom provocation task in drug-free patients who have predominantly aggression/checking symptoms (Checkers) and patients with contamination/washing symptoms (Washers). We compared the Checkers (n = 10) and the Washers (n = 12) separately to normal controls during the symptom provocation tasks using fMRI (functional magnetic resonance imaging). Moreover, we performed correlative analysis in each OCD group between brain activation and symptom severity. The Checkers showed hypoactivation in the left caudate and left anterior cingulate cortex (ACC) compared to the normal controls and a positive correlation between activated brain areas and symptom severity in the left ACC. The Washers showed hyperactivation in several bilateral cortico-cerebellar regions and a positive correlation between symptom severity and the bilateral fronto-temporal gyrus. We suggest that the caudate and ACC are associated with checking rituals and that large cortical brain regions are related to washing rituals.

    DOI: 10.1016/j.pnpbp.2012.09.002

  • Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder Exploring task-specific, stimulant medication, and age effects Reviewed

    Heledd Hart, Joaquim Radua, Tomohiro Nakao, David Mataix-Cols, Katya Rubia

    JAMA Psychiatry   70 ( 2 )   185 - 198   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Context: Functional magnetic resonance imaging studies in attention-deficit/hyperactivity disorder (ADHD) revealed fronto-striato-parietal dysfunctions during tasks of inhibition and attention. However, it is unclear whether task-dissociated dysfunctions exist and to what extent they may be influenced by age and by long-term stimulant medication use. Objective: To conduct a meta-analysis of functional magnetic resonance imaging studies in ADHD during inhibition and attention tasks, exploring age and long-term stimulant medication use effects. Data Sources: Pub-Med, Science-Direct, Web of Knowledge, Google Scholar, and Scopus databases were searched up to May 2012 for meta-analyses. Meta-regression methods explored age and long-term stimulant medication use effects. Study Selection: Twenty-one data sets were included for inhibition (287 patients with ADHD and 320 control subjects), and 13 data sets were included for attention (171 patients with ADHD and 178 control subjects). Data Extraction: Peak coordinates of clusters of significant group differences, as well as demographic, clinical, and methodological variables, were extracted for each study or were obtained from the authors. Data Synthesis: Patients with ADHD relative to controls showed reduced activation for inhibition in the right inferior frontal cortex, supplementary motor area, and anterior cingulate cortex, as well as striato-thalamic areas, and showed reduced activation for attention in the right dorsolateral prefrontal cortex, posterior basal ganglia, and thalamic and parietal regions. Furthermore, the meta-regression analysis for the attention domain showed that long-term stimulant medication use was associated with more similar right caudate activation relative to controls. Age effects could be analyzed only for the inhibition meta-analysis, showing that the supplementary motor area and basal ganglia were underactivated solely in children with ADHD relative to controls, while the inferior frontal cortex and thalamus were underactivated solely in adults with ADHD relative to controls. Conclusions: Patients with ADHD have consistent functional abnormalities in 2 distinct domain-dissociated right hemispheric fronto-basal ganglia networks, including the inferior frontal cortex, supplementary motor area, and anterior cingulate cortex for inhibition and dorsolateral prefrontal cortex, parietal, and cerebellar areas for attention. Furthermore, preliminary evidence suggests that long-term stimulant medication use may be associated with more normal activation in right caudate during the attention domain.

    DOI: 10.1001/jamapsychiatry.2013.277

  • [Neuro-pathophysiological hypothesis of obsessive compulsive disorder based on the findings from neuroimaging studies]. Reviewed

    Keitaro Murayama, Tomohiro Nakao, Shigenobu Kanba

    Unknown Journal   104 ( 5 )   81 - 88   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder. Reviewed International journal

    Murayama K, Tomohiro Nakao

    2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • インターネットを利用した実態調査—強迫性障害の行動療法について—

    吉里千佳, 海老原竜二, 吉岡和子, 飯倉康郎, 鍋山麻衣子, 中尾智博, 加藤奈子, 多田恭子, 中川彰子

    九神精医   2006.12

▼display all

Books

  • アンガーマネジメント・ワークブック

    ロバート W ネイ(Original_author:ロバート W ネイ ,  監訳)

    金剛出版  2024.7 

     More details

    Total pages:300   Responsible for pages:300   Book type:Scholarly book

  • 強迫症治療マニュアル

    エドナ・B・フォア、エルナ・ヤーディン、トレイシー・K・リッチナー(Role:Supervisor (editorial) ,  Original_author:エドナ・B・フォア、エルナ・ヤーディン、トレイシー・K・リッチナー ,  監修)

    金剛出版  2024.6 

     More details

    Total pages:200   Responsible for pages:200  

  • 精神療法の理論と実践

    中尾智博(Role:Sole author ,  Original_author:中尾智博 ,  単著)

    金剛出版  2022.8 

     More details

    Total pages:210   Responsible for pages:210  

  • 強迫性障害のための身につける行動療法

    飯倉康郎, 芝田寿美男, 中尾智博, 中川彰子(Role:Joint author)

    岩崎学術出版社  2012.5 

     More details

    Language:Japanese   Book type:Scholarly book

  • 双極性障害の治療方法. 認知行動療法(CBT), 対人関係・社会生活リズム療法(IPSRT), 専門医のための精神科臨床リュミエール6 双極性障害

    中尾智博, 神庭重信(分担)大森哲郎編(Role:Joint author)

    2008.8 

     More details

    Language:Japanese   Book type:Scholarly book

  • 認知療法2006.第5回日本認知療法学会から

    中尾智博(分担執筆) 貝谷久宣編著(Role:Joint author)

    星和書店  2006.1 

     More details

    Responsible for pages:OCDに対する行動療法の神経科学的基盤(p103-117)   Language:Japanese   Book type:Scholarly book

  • 強迫性障害治療ハンドブック

    中尾智博, 神庭重信(分担執筆) 原田誠一編著(Role:Joint author)

    金剛出版  2006.1 

     More details

    Responsible for pages:強迫性障害の薬物療法(p204-227)   Language:Japanese   Book type:Scholarly book

  • 強迫性障害の行動療法

    中尾智博(分担執筆) 飯倉康郎編著(Role:Joint author)

    金剛出版  2005.1 

     More details

    Responsible for pages:強迫性障害の外来治療.外来治療の進め方の基本(p85-113)   Language:Japanese   Book type:Scholarly book

  • 今日の治療指針2018年版

    中尾智博(Role:Joint author)

    医学書院  2018.1 

     More details

    Language:Japanese  

  • Depression Strategy: 強迫症/強迫性障害と併存するうつ病の特徴とその治療

    中尾智博

    先端医学社  2017.6 

     More details

    Language:Japanese   Book type:Scholarly book

  • 身体化障害, 疼痛性障害, 心気症. 今日の治療指針2017年版

    中尾 智博(Role:Joint author)

    2017.6 

     More details

    Language:Japanese   Book type:Scholarly book

  • 強迫性障害. 南山堂医学大辞典 第20版

    中尾 智博(Role:Joint author)

    南山堂  2015.4 

     More details

    Responsible for pages:p567   Language:Japanese   Book type:General book, introductory book for general audience

  • 重症化させないための精神疾患の診方と対応

    中尾 智博(Role:Joint author)

    医学書院  2014.7 

     More details

    Responsible for pages:pp161-170   Language:Japanese   Book type:Scholarly book

  • 強迫およびその関連障害—強迫スペクトラム障害(OCSD)を中心に. 塩入俊樹・松永寿人編; 不安障害診療のすべて

    中尾 智博(Role:Joint author)

    医学書院  2013.5 

     More details

    Responsible for pages:pp257-264   Language:Japanese   Book type:Scholarly book

  • OCDに対する行動療法の神経科学的基盤.貝谷久宣編:認知療法2006.第5回日本認知療法学会から

    中尾智博

    2006.10 

     More details

    Responsible for pages:pp103-117   Book type:General book, introductory book for general audience

  • 強迫性障害の薬物療法.原田誠一編:強迫性障害治療ハンドブック

    中尾智博, 神庭重信

    2006.6 

     More details

    Responsible for pages:pp204-227   Book type:General book, introductory book for general audience

▼display all

Presentations

  • Neurobiological heterogeneities of OCD. Symposium: Biological approaches toward clarifying heterogeneities of obsessive-compulsive disorder. International conference

    Tomohiro Nakao

    12th WFSBP  2015.6 

     More details

    Event date: 2016.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Greece  

  • 不安障害はどこまで脳の病気か ー脳画像研究のポテンシャル Invited

    中尾 智博

    第6回日本不安障害学会  2014.2 

     More details

    Event date: 2014.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Regional gray and white matter volume abnormalities in obsessive- compulsive disorder: A voxel-based morphometry study. International conference

    Nakao T, Togao O, Yoshiura T, Sanematsu H, Murayama K, Okada K, Kanba S

    10th World Congress of Biological Psychiatry  2012.5 

     More details

    Event date: 2011.5 - 2011.6

    Venue:Prague   Country:Czech Republic  

  • OCDの行動療法と薬物療法—機能的脳画像による治療効果の検証—

    中尾智博

    第33回日本生物学的精神医学会  2011.5 

     More details

    Event date: 2011.5

    Venue:東京   Country:Japan  

  • Duration effect of OCD on cognitive function: a functional MRI study.

    Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, Yoshioka K, Tomita M, Kuroki T and Kanba S

    第28回日本生物学的精神医学会  2006.9 

     More details

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

    Duration effect of OCD on cognitive function: a functional MRI study.

  • OCD関連障害をめぐって〜とくにセロトニンの脳内作用との関連;機能的脳画像と認知機能評価によるOCDの病態解明ーSSRIの効果をめぐってー. Invited

    中尾智博,黒木俊秀

    第102回日本精神神経学会総会  2006.5 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 認知療法の中枢神経系基盤:神経画像の知見を中心に.OCDに対する行動療法の神経科学的基盤 Invited

    中尾智博

    第5回日本認知療法学会  2006.12 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • Brain changes in patients with OCD brought by BT and SSRI: a cognitive and symptom provocation fMRI study International conference

    Nakao T, Yoshiura T, Nakagawa A, Kuroki T

    World Congress of Behavioral and Cognitive Therapies  2004.7 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

    Brain changes in patients with OCD brought by BT and SSRI: a cognitive and symptom provocation fMRI study

  • Advance in neuroimaging and psychopharmacology of mental disorders. Invited International conference

    Nakao T, Kanba S

    3rd CINP Asia pacific regional meeting  2007.3 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Country:Thailand  

  • 神経心理検査とfunctional MRIを用いた強迫性障害患者のワーキングメモリー機能の測定

    中尾智博,中川彰子, 鍋山麻衣子, 實松寛晋, 吉岡和子, 富田真弓, 吉浦敬, 黒木俊秀, 神庭重信

    第28回日本生物学的精神医学会  2007.7 

     More details

    Country:Japan  

  • OCDの病態と治療反応性の関連 Invited

    中尾智博

    OCD研究会  2007.11 

     More details

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 強迫性障害の病態解明に向けた脳構造・遺伝子解析 Invited

    中尾 智博

    第7回日本不安症学会学術集会  2015.2 

     More details

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島   Country:Japan  

  • Decreased brain gyrification in hoarding disorder

    中尾智博

    International Convention & Exhibition Center (ICEC)  2024.6 

     More details

    Event date: 2024.6

    Venue:イスタンブール   Country:Turkey  

  • 大学におけるCBT専門医育成のための取り組み. Invited

    中尾智博

    第20回日本認知療法・認知行動療法学会  2020.11 

     More details

    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Neurobiological basis of different clinical phenotypes in OCD International conference

    Nakao T

    6th Congress of Asian College of Neuropsychopharmacology  2019.10 

     More details

    Event date: 2019.10 - 2020.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • A biological investigation of OCD and Hoarding Disorder by neuroimaging methods Invited International conference

    Nakao T

    40th JSBP  2019.6 

     More details

    Event date: 2019.9 - 2019.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 診断と見立て:類型化と個別化の狭間で

    中尾智博

    第114回日本精神神経学会学術総会  2018.6 

     More details

    Event date: 2019.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 九大精神科における専門研修プログラム

    中尾智博, 神庭重信

    第113回日本精神神経学会学術総会  2017.6 

     More details

    Event date: 2018.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • The clinical features of Japanese patients with Hording Disorder International conference

    Nakao T, Yamada S, Murayama K, Kuwano M

    ISAD Conference 2017. The International Society of Affective Disorders  2017.7 

     More details

    Event date: 2018.6

    Language:English  

    Country:Japan  

  • ASDの強迫症状に対する治療戦略. シンポジウム「広汎性発達障害における薬物療法」 Invited

    中尾 智博

    第26回日本精神神経薬理学会  2016.11 

     More details

    Event date: 2017.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大分   Country:Japan  

  • 日常診療におけるうつ病への対応 Invited

    中尾 智博

    平成28年度福岡県医師会研修会. 一般科医・産業医のための心の健康対応力向上研修  2017.1 

     More details

    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • A fMRI study during a social situation task in patients with social anxiety disorder and controls. International conference

    Nakao T, Sanematsu H, Yoshiura T, Tomita M, Masuda Y, Kanba S

    2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP  2008.9 

     More details

    Event date: 2008.9

    Country:Japan  

  • 社会不安障害の行動療法. Invited

    中尾智博

    岡山精神神経科診療所協会例会  2006.1 

     More details

    Presentation type:Oral presentation (invited, special)  

    Venue:岡山   Country:Japan  

  • 強迫関連障害における最近の知見 Invited

    中尾 智博

    筑豊精神科集談会特別講演  2013.2 

     More details

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:飯塚   Country:Japan  

▼display all

MISC

  • Neurobiological model of obsessive-compulsive disorder: Evidence from recent neuropsychological and neuroimaging findings

    Tomohiro Nakao

    Psychiatry Clin Neurosci   2014.8

     More details

    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 日常の面接で何を聴き、話し、残すか. オピニオン・精神科医にとっての精神療法の意味

    中尾 智博

    2013.9

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 強迫性障害とhoarding(溜め込み)

    中尾智博

    臨床精神医学   2012.1

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 強迫性障害の生物学ー臨床理論と神経生物学理論の統合モデルー

    中尾智博

    臨床精神医学   2006.6

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • A multicenter, single-group, open feasibility study of a new individual cognitive behavioral therapy program for adult Japanese patients with attention-deficit/hyperactivity disorder: Study protocol(タイトル和訳中)

    Takamatsu Naoki, Nakashima Misuzu, Matsuura Kei, Umemoto Ikue, Ito Masaya, Kanazawa Junichiro, Tomiyama Hirofumi, Kondo Masaki, Tachimori Hisateru, Nakao Tomohiro, Horikoshi Masaru, Kuga Hironori

    Psychiatry and Clinical Neurosciences Reports   3 ( 4 )   pcn5.70036 - pcn5.70036   2024.12

     More details

    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

  • AIF1遺伝子(Iba-1のコード化遺伝子)を欠失した双極性障害の1例 血液由来ミクログリア様細胞を用いたin vitroでの試験的解析(A case of bipolar disorder with AIF1(coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells)

    Ohgidani Masahiro, Kushima Itaru, Inamine Shogo, Kyuragi Sota, Sagata Noriaki, Nakao Tomohiro, Kanba Shigenobu, Ozaki Norio, Kato Takahiro A.

    Psychiatry and Clinical Neurosciences   77 ( 1-2 )   128 - 130   2023.2   ISSN:1323-1316

     More details

    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

  • 精神科医に必要とされるもの−精神療法マインドと見立ての力を育むために−. 特集「標準的精神科医」へのすすめ−プロと呼ばれるために私たちは何を習得すればよいか Reviewed

    中尾智博

    神科治療学   2021.2

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • うつ病・不安症の理解と治療. 私の診療経験から

    中尾智博

    臨床と研究   2018.12

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    Repository Public URL: http://hdl.handle.net/2324/4479044

  • 強迫性障害の認知行動療法

    中尾智博

    精神医学   2017.5

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • DSM-5の強迫関連症群の概要と臨床的意義—ためこみ症を中心に—. 特集 強迫症の理解と治療の新たな展開Ⅰ

    中尾 智博

    精神科治療学   2017.3

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 大学病院での私の行動療法. 現在の病態に対する<私の>精神療法.

    中尾 智博

    精神療法増刊第2号   2015.6

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • OCDの行動療法と薬物療法—機能的脳画像による効果の検証

    中尾 智博

    日本生物学的精神医学会誌   2012.8

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • OCDの病態と治療反応性の関連

    中尾智博

    強迫性障害の研究,星和書店   2008.4

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 強迫性障害の認知機能と小脳

    中尾智博

    分子精神医学   2007.1

  • 強迫性障害の脳画像

    中尾智博

    精神科   2006.9

     More details

    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Professional Memberships

  • 九州精神神経学会

  • 日本精神神経学会

  • 日本生物学的精神医学会

  • 日本行動療法学会

  • 日本不安症学会

Committee Memberships

  • 日本うつ病センター   Executive   Domestic

    2024.5 - 2026.5   

  • 日本認知療法・認知行動療法学会   Organizer   Domestic

    2023.4 - 2024.5   

  • 日本精神神経学会   Executive   Domestic

    2012.6 - 2025.6   

  • 日本精神神経学会   副理事長、研修委員会委員長、精神神経誌編集委員長、精神療法委員会担当理事   Domestic

    2012.6 - 2025.6   

  • 日本不安障害学会   Councilor   Domestic

    2010.4 - 2012.8   

  • 日本生物学的精神医学会   Councilor   Domestic

    2007.12 - 2009.3   

▼display all

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2017

     More details

    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • 座長(Chairmanship)

    第69回九州精神神経学会  ( Japan ) 2016.12

     More details

    Type:Competition, symposium, etc. 

  • 司会(Moderator)

    第11回「精神科面接の基本」研修会  ( Japan ) 2015.4

     More details

    Type:Competition, symposium, etc. 

  • 委員

    精神療法委員会  ( Japan ) 2015.4 - 2017.3

     More details

    Type:Competition, symposium, etc. 

    Number of participants:10

  • シンポジスト International contribution

    Neurobiological model of obsessive-compulsive disorder: Evidence from recent neuroimaging findings, Satellite symposium on obsessive-compulsive disorder. 11th World congress of biological psychiatry  ( Kyoto Japan ) 2013.6

     More details

    Type:Competition, symposium, etc. 

    Number of participants:1,000

  • 座長、シンポジスト

    第5回日本不安障害学会シンポジウム「強迫性障害のサブタイプと治療選択〜合理的治療ストラテジーを求めて」  ( Japan ) 2013.2

     More details

    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第4回日本不安障害学会  ( Japan ) 2012.2

     More details

    Type:Competition, symposium, etc. 

  • シンポジウムのコーディネーター

    日本精神経学会  ( Japan ) 2010.5

     More details

    Type:Competition, symposium, etc. 

    Number of participants:5,000

▼display all

Research Projects

  • 拡散テンソル画像等によるためこみ症の脳構造異常の解明

    2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 拡散テンソル画像等によるためこみ症の脳構造異常の解明

    Grant number:21K07547  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 精神保健医療従事者による、新型コロナウイルス感染症や自然災害等に起因した心のケアに対する心理的アセスメント及び応急処置介入方法の適切な提供体制の構築と、それに伴うメンタルヘルスの維持向上に資する研究

    Grant number:21446330  2021 - 2022

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

      More details

    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 安静時機能的脳画像を用いたためこみ症の脳病態解明

    Grant number:18K07603  2018 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • ためこみ症と強迫症・不安症の生物学的差異の検討

    Grant number:15K09834  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • ためこみ症と強迫症・不安症の生物学的差異の検討

    Grant number:15K09834  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • Hoarding(溜め込み癖)と児童思春期に発症する精神疾患の関連についての疫学的研究

    2013 - 2014

    明治安田こころの健康財団2013年度研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 溜め込み障害と強迫性障害の臨床的および生物学的差異の検討

    Grant number:24591719  2012 - 2014

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

  • 治療抵抗性強迫性障害に対するアリピプラゾール増強療法:無作為化プラセボ対照二重盲検比較試験

    2012 - 2013

    臨床研究中核病院整備事業による臨床試験支援補助金

      More details

    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 脳構造及び遺伝子異常からみた強迫性障害の疾患内異種性の研究

    2012

    先進医薬研究振興財団 精神薬療分野 一般研究助成

      More details

    Authorship:Principal investigator  Grant type:Contract research

  • 強迫性障害の前向き長期予後研究

    2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 脳画像解析と分子遺伝学的解析による強迫性障害の病態研究

    2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • functional MRIを用いた社会不安障害の研究

    Grant number:18790836  2006 - 2008

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

      More details

    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Educational Activities

  • 医学部4年生「臨床医学基本実習」担当
    臨床医学V-③ 心身医学・精神医学概論 担当
    基幹教育科目「生命と科学A」担当

Class subject

  • カウンセリング論講義Ⅱ(精神疾患とその治療)

    2025.8 - Present   Second semester

  • 医学科3年生「精神医学」

    2023.9 - Present   Second semester

  • 医歯薬合同講義「臨床医学Ⅴ-③」

    2023.5 - Present  

  • 医学科2年生「精神医学」

    2023.4 - Present   First semester

  • 医学部講義・精神医学

    2020.10 - 2021.3   Second semester

  • 医歯薬合同講義「臨床医学Ⅴ-③」

    2020.4 - 2020.9   First semester

  • 教育心理大学院精神医学各論

    2018.4 - 2018.9   First semester

  • 教育心理大学院精神医学各論

    2016.4 - 2016.9   First semester

  • 医学部講義・精神医学

    2015.10 - 2016.3   Second semester

  • 教育心理大学院精神医学各論

    2015.4 - 2015.9   First semester

  • 医学部講義・精神医学

    2014.10 - 2015.3   Second semester

  • 教育心理大学院精神医学各論

    2014.4 - 2014.9   First semester

  • 医学部講義・精神医学

    2013.10 - 2014.3   Second semester

  • 教育心理大学院精神医学各論

    2013.4 - 2013.9   First semester

  • 医学部講義・精神医学

    2012.10 - 2013.3   Second semester

  • 教育心理大学院精神医学各論

    2012.4 - 2012.9   First semester

  • 精神医学

    2011.10 - 2012.3   Second semester

  • 心理学大学院講義・精神医学

    2011.4 - 2011.9   First semester

▼display all

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  産業医科大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2024  令和健康科学大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  令和健康科学大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

Other educational activity and Special note

  • 2018  Special Affairs  2018/3-17-18、不安障害学会において強迫症の認知行動療法に関する研修会を開催した。

     詳細を見る

    2018/3-17-18、不安障害学会において強迫症の認知行動療法に関する研修会を開催した。

  • 2018  Special Affairs  CBT研修会にて不安症の認知行動療法に関する講義の講師を務めた。

     詳細を見る

    CBT研修会にて不安症の認知行動療法に関する講義の講師を務めた。

  • 2006  Special Affairs  福岡大学精神科にて同科医局員を対象として、OCDに対する行動療法の神経科学的基盤についての講義を行った。

     詳細を見る

    福岡大学精神科にて同科医局員を対象として、OCDに対する行動療法の神経科学的基盤についての講義を行った。

  • 2004  Special Affairs  肥前精神医療センターで2005.1.26-28に行われた行動療法研修会において、医療関係者を対象とした強迫性障害の行動療法に関する研修の講師を務めた。

     詳細を見る

    肥前精神医療センターで2005.1.26-28に行われた行動療法研修会において、医療関係者を対象とした強迫性障害の行動療法に関する研修の講師を務めた。

Outline of Social Contribution and International Cooperation activities

  • 専門書および一般向け書物を通じて強迫性障害やパニック障害をはじめとした不安障害の病態、治療についての解説を行っている。また所属する行動療法研究室のインターネット上のサイトでも強迫性障害の治療についての解説とメール相談に応じ、同疾患の一般に向けた啓蒙活動を行っている。

Social Activities

  • プライマリーケアにおけるうつ・不安への対応.

    福岡市医師会  2020.12

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 災害とメンタルヘルス.

    第2回九州大学SDGs市民のための津波防災シンポジウム  2019.3

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 市復職審査委員会委員

    福岡市  福岡市役所  2006.12

     More details

    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Other

Media Coverage

  • 「いつか使うかも」「思い出の品だから」モノを捨てられない人に潜む《ためこみ症》という心の病 片付け業者よりも必要な対策とは? Internet

    東洋経済新報社  東洋経済オンライン  ライフ 「病気」と「症状」の対処法  2025.4

  • その収集癖「ためこみ症」かも? Newspaper, magazine

    西日本新聞朝刊記事, 2019.5.22  2019.5

     More details

    その収集癖「ためこみ症」かも?

  • パニック障害について TV or radio program

    KBCテレビ「とっても健康ランド」  2019.2

     More details

    パニック障害について

  • ためこみ症について. 健康のページこころ(読売新聞夕刊記事) Newspaper, magazine

    読売新聞夕刊記事  2016.8

     More details

    ためこみ症について. 健康のページこころ(読売新聞夕刊記事)

  • 実地臨床で診られる“こだわり症状”についての解説

    エムスリー  2013.4

     More details

    実地臨床で診られる“こだわり症状”についての解説

  • 女性の医学最前線「強迫性障害」 Newspaper, magazine

    婦人公論2006年6月7日号  2006.6

     More details

    女性の医学最前線「強迫性障害」

  • 医療と健康面「パニック障害」 Newspaper, magazine

    西日本新聞2005年11月21日付朝刊  2005.11

     More details

    医療と健康面「パニック障害」

▼display all

Travel Abroad

  • 2024.10

    Staying countory name 1:France   Staying institution name 1:パリ市15区区役所 31 Rue Péclet, 75015 Paris

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Psychiatry and Neuroscience

Clinician qualification

  • Specialist

    The Japanese Society of Psychiatry and Neurology(JSPN)

Year of medical license acquisition

  • 1995

Notable Clinical Activities

  • ・不安障害(特に強迫性障害、ためこみ症)と行動療法を専門領域として臨床および研究活動を行っている。 ・新型コロナウイルスによって生じるメンタルヘルスの問題への臨床的対応および研究活動を行っている。