Kyushu University Academic Staff Educational and Research Activities Database
Researcher information (To researchers) Need Help? How to update
Yoshiko Miura Last modified date:2020.06.30

Professor / Department of Chemical Systems and Engineering, Graduate School of Engineering, Graducate School of Engineering,
Department of Chemical Engineering
Faculty of Engineering

Graduate School
Undergraduate School

 Reseacher Profiling Tool Kyushu University Pure
Web site of Lab 9, Department of Chemical Engineering, Kyushu University .
Academic Degree
Dr of Engineering, Kyoto University
Country of degree conferring institution (Overseas)
Field of Specialization
Biopolymers, Functional Polymer, Polymer Synthesis
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
[Research Activities]
(1) Bio-functional materials by Glycopolymers
(2) Immobilized Catalyst with porous polymer and the process with it.

Elementary Organic Chemistry (1st year)
Physical Chemistry I(2nd year, Chemical Engineering)
Physical Chemistry III(3rd year, Chemical Engineeing)
Bio-resource Material Engineering (Graduate School)

I am also in charge of the research education of bachelor, master and doctor course students.

[International Activities]
I am working on International research activities with US, Canada and Korea . I am in charge of Organizer of International Conferences and Symposium .
Associate editor of Chemistry Letters, Advisory board of Journal of Materials Chemistry B and Trends in Glycoscience and Glycotechnology. Editorial Board of Membrane, and Applied Science.
Research Interests
  • Immobilized catalyst with porous polymers
    keyword : Immoblized catalyst, porous polymer, flow synthetic process
  • Separation Membrane with polymer monolith
    keyword : Porous polymer, polymer monolith
  • Development of Oligosaccharide mimic with glyco-module method
    keyword : Saccharide、Module, Glycopolymer, SPR
  • Separation of Biomolecules with metal mesh device
    keyword : Metal Mesh Device, Bioseparation
  • Flow organic synthesis with polymer monolith
    keyword : Polymer monlith reactor
  • CO2 separation by polymer monolith
    keyword : Polymer Monolith
  • Bioseparation by Polymer Monolith
    keyword : Polymer Monolith
  • Catalysis with Polymer nanogel
    keyword : Polymer, Nanogel, Catalysis
  • The material fabrication with branched polymer interface
    keyword : Interface, Branched Polymer
  • Biomaterials with Glycopolymer
    keyword : Glycopolymer、Biopolymer, Infection Disease
Academic Activities
1. Mizuo Maeda, Atsuhi Takahara, Hiromi Kitano, Tetsuji Yamaoka, Yoshiko Miura, Molecular Soft-Interface Science: Principles, Molecular Design, Characterization and Application, Springer, 2019.05.
1. Yoshiko Miura, Controlled Polymerization for the development of bioconjugate polymers and materials, Journal of Materials Chemistry B, 10.1039/C9TB02418B, 2020, 8, 2010-2019, 2020.01, Controlled polymerization through living radical polymerization is widely studied. Controlled polymerization enables synthetic polymers with precise structures, which have the potential for excellent bio-functional materials. This review summarizes the applications of controlled polymers, especially those via living radical polymerization, to biofunctional materials and conjugation with biomolecules. In the case of polymer ligands like glycopolymers, the polymers control the interactions with proteins and cells based on the precise polymer structures. Living radical polymerization enables the conjugation of polymers to proteins, antibodies, nucleic acids and cells. Those polymer conjugations are a sophisticated method to modify bio-organisms. The polymer conjugations expand the potential of biofunctional materials and are useful for understanding biology..
1. Takahiro Oh, Kazuki Jono, Yuri Kimoto, Yu Hoshino, Yoshiko Miura, Preparation of multifunctional glycopolymers using double orthogonal reactions and the effect of electrostatic groups on the glycopolymer–lectin interaction, Polymer Journal, 10.1038/s41428-019-0244-x, 51, 12, 1299-1308, 2019, 51,12,1299-1308, 2019.08, We investigated synthetic biomacromolecules to control molecular interactions. Multifunctional glycopolymers for molecular recognition were prepared via living radical polymerization and post-click chemistry with orthogonal Huisgen and thiol-epoxy reactions. The synthesis of the polymer backbone and the subsequent side-chain introduction successfully proceeded in high yield. The multifunctional glycopolymers had a tri-block structure: the first and third blocks contained mannose, and the second block contained either a positively or negatively charged group or a neutral hydrophilic group. The molecular recognition of the glycopolymers toward lectin was evaluated via fluorescence quenching measurements. Because of the electrostatic interaction, the binding constant varied in the following order: positively charged glycopolymer (PT110) > negatively charged glycopolymer (NT110). The effect of the electrostatic interactions was modest compared with the effect of the carbohydrate–lectin binding. These results suggested that the carbohydrate–lectin interaction was an important factor in the molecular recognition of glycopolymers. This study provides guidelines for the preparation of multifunctional polymers, such as biomaterials..
2. Yu Hoshino, Shohei Taniguchi, Hinata Takimoto, Sotaro Akashi, Sho Katakami, Yusuke Yonamine, Yoshiko Miura, Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide, Angewandte Chemie - International Edition, 10.1002/anie.201910558, 59, 2, 679-683, 2020, 132,2,689-693., 2020.01, Abiotic ligands that bind to specific biomolecules have attracted attention as substitutes for biomolecular ligands, such as antibodies and aptamers. Radical polymerization enables the production of robust polymeric ligands from inexpensive functional monomers. However, little has been reported about the production of monodispersed polymeric ligands. Herein, we present homogeneous ligands prepared via radical polymerization that recognize epitope sequences on a target peptide and neutralize the toxicity of the peptide. Taking advantage of controlled radical polymerization and separation, a library of multifunctional oligomers with discrete numbers of functional groups was prepared. Affinity screening revealed that the sequence specificity of the oligomer ligands strongly depended on the number of functional groups. The process reported here will become a general step for the development of abiotic ligands that recognize specific peptide sequences..
3. Yoshiko Miura, Controlled polymerization for the development of bioconjugate polymers and material, Journal of Materials Chemistry B, 10.1039/c9tb02418b, 8, 10, 2010-2019, 2020.03, Controlled polymerization through living radical polymerization is widely studied. Controlled polymerization enables synthetic polymers with precise structures, which have the potential for excellent bio-functional materials. This review summarizes the applications of controlled polymers, especially those via living radical polymerization, to biofunctional materials and conjugation with biomolecules. In the case of polymer ligands like glycopolymers, the polymers control the interactions with proteins and cells based on the precise polymer structures. Living radical polymerization enables the conjugation of polymers to proteins, antibodies, nucleic acids and cells. Those polymer conjugations are a sophisticated method to modify bio-organisms. The polymer conjugations expand the potential of biofunctional materials and are useful for understanding biology..
4. Nagao,M., Matsubara, T., Hoshino, Y., Sato, T., Miura, Y., Synthesis of Various Glycopolymers Bearing Sialyllactose and the Effectof Their Molecular Mobility on Interaction with the Influenza Virus, Biomacromolecules, doi/10.1021/acs.biomac.9b00515, 20, 7, 2763-2769, 2019, 20, 7, 2763-2769, 2019.06.
5. Masanori Nagao, Teruhiko Matsubara, Yu Hoshino, Toshinori Sato, and Yoshiko Miura, Topological Design of Star Glycopolymers for Controlling the Interaction with the Influenza Virus, Bioconjugate Chemistry, 10.1021/acs.bioconjchem.9b00134, 30, 1192-1198, Bioconjugate Chemistry 2019,30,1192-1198, 2019.04, The precise design of synthetic polymer ligands using controlled polymerization techniques provides an advantage for the field of nanoscience. We report the topological design of glyco-ligands based on synthetic polymers for targeting hemagglutinin (HA, lectin on the influenza virus). To achieve precise arrangement of the glycounits toward the sugar-binding pockets of HA, triarm star glycopolymers were synthesized. The interaction of the star glycopolymers with HA was found to depend on the length of the polymer arms and was maximized when the hydrodynamic diameter of the star glycopolymer was comparable to the distance between the sugar-binding pockets of HA. Following the formula of multivalent interaction, the number of binding sites in the interaction of the glycopolymers with HA was estimated as 1.8–2.7. Considering one HA molecule has three sugar-binding pockets, these values were reasonable. The binding mode of synthetic glycopolymer–ligands toward lectins could be tuned using controlled radical polymerization techniques..
6. Nagao Masanori, Hoshino Yu, Miura Yoshiko, Quantitative preparation of multiblock glycopolymers bearing glycounits at the terminal segments by aqueous reversible addition–fragmentation chain transfer polymerization of acrylamide monomer, Journal of Polymer Science, Part A: Polymer Chemistry, 10.1002/pola.29344, 57, 857-861, 2019,57,857-861, 2019.03.
7. Terada, Y.; Hoshino, Y.; Miura, Y., “Glycopolymers mimicking GM1 gangliosides: Cooperativity of galactose and neuraminic acid for cholera toxin recognition, Chemistry–An Asian Journal, 10.1002/asia.201900053, 14, 1021-1027, Chemistry–An Asian Journal 2019,14,1021-1027. (DOI:, 2019.03.
8. Takahiro Oh, Masanori Nagao, Yu Hoshino , and Yoshiko Miura, Self-Assembly of a Double Hydrophilic Block Glycopolymer and the Investigation of Its Mechanism, Langmuir, 10.1021/acs.langmuir.8b01527, 2018.07, [URL].
9. Hikaru Matsumoto, Takanori Akiyoshi, Yu Hoshino, and Yoshiko Miura, Size-tuned hydrogel network of palladium-confining polymer particles: a highly active and durable catalyst for Suzuki coupling reactions in water and ambient temperature, Polymer Jornal, 10.1038/ s41428-018-0102-2, 2018.07.
10. Xinnan Cui, Tatsuya Murakami, Yukihiko Tamura, Kazuhiro Aoki, Yu Hoshino, and Yoshiko Miura, Bacterial Inhibition and Osteoblast Adhesion on Ti Alloy Surfaces Modified by Poly(PEGMA-r-Phosmer) Coating, ACS Appl. Mater. Interfaces, 10.1021/acsami.8b07757, 10, 28, 23674-23681, 2018, 10 (28), 23674–23681, 2018.06, [URL], We have synthesized and immobilized PEGMA500-Phosmer to Ti6Al4V surfaces by a simple procedure to reduce bacteria-associated infection without degrading the cell response. Adhered bacteria coverage was lessened to 1% on polymer-coated surfaces when exposed to Escherichia coli, Staphylococcus epidermidis, and Streptococcus mutans. Moreover, PEGMA500-Phosmer and homoPhosmer coatings presented better responses to MC3T3-E1 preosteoblast cells when compared with the results for PEGMA2000-Phosmer-coated and raw Ti alloy surfaces. The behavior of balancing bacterial inhibition and cell attraction of the PEGMA500-Phosmer coating was explained by the grafted phosphate groups, with an appropriate PEG brush length facilitating greater levels of calcium deposition and further fibronectin adsorption when compared with that of the raw Ti alloy surface..
11. Hiroyuki Koide, Keiichi Yoshimatsu, Yu Hoshino, Shih-Hui Lee, Saki Arizumi, Yudai Narita, Yusuke Yonamine, Adam C. Weisman, Yuri Nishimura, Naogo Oku, Yoshiko Miura, Kenneth J Shea, A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165), Nature Chemistry, 10.1038/nchem.2749, 9, 715-722, 9, pages 715–722 (2017), 2017.03, [URL], Protein affinity reagents are widely used in basic research, diagnostics and separations and for clinical applications, the most common of which are antibodies. However, they often suffer from high cost, and difficulties in their development, production and storage. Here we show that a synthetic polymer nanoparticle (NP) can be engineered to have many of the functions of a protein affinity reagent. Polymer NPs with nM affinity to a key vascular endothelial growth factor (VEGF165) inhibit binding of the signalling protein to its receptor VEGFR-2, preventing receptor phosphorylation and downstream VEGF165-dependent endothelial cell migration and invasion into the extracellular matrix. In addition, the NPs inhibit VEGF-mediated new blood vessel formation in Matrigel plugs in vivo. Importantly, the non-toxic NPs were not found to exhibit off-target activity. These results support the assertion that synthetic polymers offer a new paradigm in the search for abiotic protein affinity reagents by providing many of the functions of their protein counterparts..
12. Masanori Nagao, Yuuki Kurebayashi, Hirokazu Seto, Tadanobu Takahashi, Takashi Suzuki, Yu Hoshino, Yoshiko Miura, Polyacrylamide backbones for polyvalent bioconjugates using “post-click” chemistry”, Polymer Chemistry, 2016.07.
13. Yoshiko Miura, Yu Hoshino, Hirokazu Seto, Glycopolymer Nanobiotechnology, Chemical Reviews, 10.1021/acs.chemrev.5b00247, 116, 1673-1692, 2016.02, Previous studies have clearly shown the importance of the multivalent effect in saccharide–protein interactions. To investigate the multivalent effect, the use of multivalent compounds or “glycoclusters” is indispensable, and many groups have reported syntheses of glycocluster compounds. Examples of glycoclusters include liposomes with glycolipids, glycocalixarenes, glycocyclodextrins, glycopeptides, and glycopolymers. Among the various synthetic glycoclusters, glycopolymers have been the subject of much attention . In this review, we define glycopolymers as polymers carrying pendant saccharides. Since glycopolymers have larger valencies than other multivalent compounds, they show the largest amplification effects in molecular recognition. Glycopolymers are able to be prepared as nanomaterials by controlled polymerization. In this section of the review, we discuss glycopolymers and their application for biotechnology..
14. Xinnan Cui, Hirokazu Seto, Tatsuya Murakami, Yu Hoshino, Yoshiko Miura, Inhibition of Bacterial Adhesion on Hydroxyapatite Model Teeth by Surface Modification with PEGMA-Phosmer Copolymers, ACS Biomater. Sci. Eng, 10.1021/acsbiomaterials.5b00349, 2, 2, 205-212, 2016.02, Modification of the interface properties on hydroxyapatite and tooth enamel surfaces was investigated to fabricate bacterial resistance in situ. A series of copolymers containing pendants of poly(ethylene glycol) methyl ether methacrylate (PEGMA) and ethylene glycol methacrylate phosphate (Phosmer) were polymerized by conventional free radical polymerization and changing the feed ratio of monomers. The copolymers were immobilized on hydroxyapatite and tooth enamel via the affinity of phosphate groups to hydroxyapatite to form the stable and durable polymer brushes on the surfaces. The amounts of polymer immobilized depended on the phosphate group ratio in the copolymers. Surface modification altered the interfacial properties of hydroxyapatite and inhibited bacterial adhesion. Copolymers containing 40–60% PEGMA segments showed a significant inhibitory effect on bacterial adhesion of S. epidermidis both in the presence and absence of plaque model biomacromolecules..
15. Seto, Hirokazu; Ogata, Yutaro; Murakami, Tatsuya; Hoshino, Yu; Miura, Yoshiko , Selective Protein Separation Using Siliceous Materials with a Trimethoxysilane-Containing Glycopolymer, ACS Applied Materials & Interfaces, 10.1021/am2014713, 4, 1, 411-417, 2012, 4(1), 411-417, 2012.01, A copolymer with α-d-mannose (Man) and trimethoxysilane (TMS) units was synthesized for immobilization on siliceous matrices such as a sensor cell and membrane. Immobilization of the trimethoxysilane-containing copolymer on the matrices was readily performed by incubation at high heat. The recognition of lectin by poly(Man-r-TMS) was evaluated by measurement with a quartz crystal microbalance (QCM) and adsorption on an affinity membrane, QCM results showed that the mannose-binding protein, concanavalin A, was specifically bound on a poly(Man-r-TMS)-immobilized cell with a higher binding constant than bovine serum albumin. The amount of concanavalin A adsorbed during permeation through a poly(Man-r-TMS)-immobilized membrane was higher than that through an unmodified membrane. Moreover, the concanavalin A adsorbed onto the poly(Man-r-TMS)-immobilized membrane was recoverable by permeation of a mannose derivative at high concentration..
16. Matsumoto, Erino; Nishizawa, Kazuki; Fukuda, Tomohiro; Takai, Madoka; Miura, Yoshiko, Separation capability of proteins using microfluidic system with dendrimer modified surface , Transactions of the Materials Research Society of Japan, 36, 4, 541-544, 2011、36(4)、541-544, 2011.11.
17. Masaya Wada, Yuta Miyazawa, Yoshiko Miura, A specific Inhibitory effect of multivalent trehalose toward amyloid beta (1-40) aggregation, Polymer Chemistry, accepted, 2011.07.
18. Erino Matsumoto, Tomohiro Fukuda, Yoshiko Miura, Bioinert surface to protein adsorption with higher generation of dendrimer SAMs, Colloids and Surfaces B:Biointerfaces, doi:10.1016/j.colsurfb.2011.01.003, 84, 1, 280-284, 2011.05.
19. Jin Ishii, Masayuki Toyoshima, Miyuki Chikae, Yuzuru Takamura, Yoshiko Miura , Preparation of Glycopolymer-modified Gold Nanoparticles and a New Approach for a Lateral Flow Assay, Bull chem Soc Jpn, doi:10.1246/bcsj.2010030, 84, 5, 466-470, selected paper, 2011.05.
20. Tomohiro Fukuda, Erino Matsumoto, Nobuhiko Yui,and Yoshiko Miura, Peculiar Wettability Based on Orientational Change of Self-assembled Hemispherical PAMAM Dendrimer Layer, Chemistry Letters, doi:10.1246/cl.2010.923, 39, 9, 923, 2010, 39, 923-925, 2010.07, [URL].
21. T. Fukuda, E. Matsumoto, S. Onogi, Y. Miura, Aggregation of Alzheimer Amyloid β Peptide (1−42) on the Multivalent Sulfonated Sugar Interface, Bioconjugate Chemistry, 10.1021/bc100053x, 21, 6, 1079, 2010, 21, 1079-1086, 2010.06, [URL].
22. M. Toyoshima, T. Oura, T. Fukuda, E. Matsumoto, Y. Miura, , Biological specific recognition of glycopolymermodified interfaces by RAFT living radical polymerization, Polymer Journal, doi:10.1038/pj.2009.321, 42, 172, 2010, 42, 172-178, 2010.02, [URL].
23. yoshiko miura, Inhibition of protein amyloidosis by glycomaterials, Trends in Glycoscience and Glycotechnology, doi:10.4052/tigg.21.324, 21, 122, 324-334, 2009.12.
24. Tomohiro Fukuda, Shunsuke Onogi, Yoshiko Miura, Dendritic Sugar-Microarrays by Click Chemistry, Thin Solid Films, 518, 880-888, 2009.11.
25. Koji Funato, Naoto Shirahata, Yoshiko Miura, The monolayer of a-Man via Si-C bond formation and protein recognition, Thin Solid Films, 518, 699, 2009.11.
26. Yoshiko Miura, Kiyofumi Yamamoto, Kikuko Yasuda, Yoshihiro Nishida, Kazukiyo koabayashi, Inhibition of Alzheimer Amyloid Aggregation with Sulfate Glycopolymers, Advances in Science and Technology , 57, 166-169, 2009.08.
27. Masayuki Toyoshima, Yoshiko Miura, Preparation of GLycopolymer-Substituted Gold nanoparticles and Their Molecular Recognition, Journal of Polymer Science PartA: Polymer Chemistry, 47, 1412-1421, 2009.03.
28. Erino Matsumoto, Takanori Yamauchi, Tomohiro Fukuda, Yoshiko Miura, Sugar microarray by click chemistry, Sci. Technol. Adv. Mater. , 10, 034605, 2009.03.
29. Miyuki Chikae, Tomohiro Fukuda, K. Kerman, K. Idegami, Yoshiko Miura, Eiichi Tamiya, Amyloid beta-detection with saccharide immobilized gold nanoparticle on carbon electrode, Bioelectrochemistry, 74, 118-123, 2008.11.
30. Yoshiko Miura, Takahiro Yamauchi, Hajime Sato, Tomohiro Fukuda, The Self-Assembled Monolayer of Saccharide via Click Chemistry: Formation and Protein Recognition, Thin Solid Films, 516, 2443, 2008.09.
31. Yoshiko Miura, Chouga You, Reiko Ohnishi,, Inhibition of Alzheimer amyloid beta aggregation by polyvalent trehalose, Sci. Technol Adv Mat , 9, 24407, 2008.07.
32. Tomohiro Fukuda, Shunsuke Onogi, Yoshiko Miura, Preparation and Properties of Dendritic Sugar Immobilized Surface, Trans. Mat. Res. Soc. Jpn,, 33, 733, 2008.03.
33. Yoshiko Miura, Shunsuke Onogi, Kiyofumi Yamamoto, Synthesis of Glycodendrimer via Click Chemistry and Protein Affinities, Trans. Mat. Res. Soc. Jpn, 33, 729, 2008.03.
34. Yoshiko Miura, Kikuko Yasuda, Kiyofumi Yamamoto, Mihoko Koike, Yoshihiro Nishida, Kazukiyo Kobayashi, Inhibition of Alzhimer Amyloid Aggregation with Sulfated Glycopolymers , Biomacromolecules, 8, 2129, 2007.11.
35. Yoshiko Miura, Daisuke Kouketsu, kazukiyo Kobayashi, Synthesis and Properties of a Well-Defined Glycopolymer via Living radical Polymerization, Polymer Advanced Technology, 18, 647, 2007.07.
36. Hajime Sato, Yoshiko Miura, Nagahiro Saito, Kazukiyo Kobayashi, Osamu Takai, Fibroblastic Microfabrication by Molecular Recognition on Substrate, Surface Science, 601, 3871, 2007.04.
37. Hajime Sato, Yoshiko Miura, Nagahiro Saito, Kazukiyo Kobayashi, Osamu Takai, A Micropatterned Multifunctional Carbohydrate Display by an Orthogonal Self-Assembling Strategy, Biomacromolecules, 8, 753-756, 2007.01.
38. Yoshiko Miura, Akio Sakaki, Masamichi Kamihira, Shinji Iijima, Kazukiyo Kobayashi, A globotriaosylceramide (Gb3Cer) mimic peptide , Biochimica et Biophysica Acta, 1760, 883, 2006.09.
39. Hajime Sato, Yoshiko Miura, Takahiro Yamauchi, Kazukiyo , Carbohydrate Microarray by Click Chemistry, Trans. Mat. Res. Soc. Jpn, 31, 659, 2006.04.
40. Yoshiko Miura, The Development and the Character of Saccharide Biosensors, Trends in Glycoscience and Glycotechnology, , 18, 349, 2006.04.
41. Yoshiko Miura, Chieri Shibata, Kazukiyo Kobayashi, Theremoresponsive Self-Assembly of Short Elastin-Like Peptides , Trans Mat Res Soc Jpn, 31, 549, 2006.04.
42. Yoshiko Miura, Chieri Shibata, Kazukiyo Kobayashi, Theremoresponsive Self-Assembly of Short Elastin-Like Peptides , Trans Mat Res Soc Jpn, 31, 549, 2006.04.
43. Natsuko Wada, Yoshiko Miura, Kazukiyo Koabayashi, Synthesis and Biological Properties of Glycopolymer-Polylactide Conjugate, Trans. Mat. Res. Soc. Jpn, 32, 767, 2005.04.
44. Yoshiko Miura, Natsuko Wada, Yoshihiro Nishida, H. Mori, K. Kobayashi, Chemoenzymatic Synthesis of Glycoconjugate Polymers Starting from Non-reducing Disaccharides, J. Polym. Sci. part A Polym. Chem. 2004, 42, 4598, 42, 4598, 2004.04.
45. Yoshiko Miura, Yuki Sasao, Masamichi Kamihira, Akio Sakaki, Shinji Iijima, Kazukiyo kobayashi, Peptides binding to a Gb3 mimic selected from a phage library, Biochem. Biophys. Acta, 1673, 131, 2004.04.
46. Yoshiko Miura, takayasu ikeda, kazukiyo kobayashi, Chemoenzymatically Synthesized Glycoconjugate Polymers, Biomacromolecules, 10.1021/bm025714b, 4, 2, 410, 2003.02.
47. Y. Miura, T. Ikeda, N. Wada, K. kobayashi, Chemoenzymatic Synthesis of Glycoconjugate Polymers: Greening the Synthesis of biomaterials, Green Chemistry, 5, 610, 2003.04.
48. Y. Miura, T. Ikeda, N. Wada, K. Kobayashi, Chemoenzymatic synthesis of a Multivalent Aminoglycoside, Macromol. Biosci, 3, 362, 2003.04.
49. Yoshiko Miura, Yuuki Sasao, Hirofumi Dohi, Yoshihiro Nishida and Kazukiyo Kobayashi, Self-assembled monolayers of globotriaosylceramide (Gb3) mimics: surface-specific affinity with shiga toxins , doi:10.1016/S0003-2697(02)00318-4, 310, 27, 2002.04.
50. Y. Miura, S. Kimura, S. Kobayashi, Y. Imanishi, J. Umemura, Cation recognition by self-assembled monolayers of oriented helical peptides having a crown ether unit, Biopolymers, 55, 391, 2000.04.
51. Y. Miura, S. Kimura, Y. Imanishi, J. Umemura, Formation of Oriented Helical Peptide Layers on a Gold Surface due to the Self-assembling Properties of Peptides, Langmuir, 14, 6935, 1998.04.
52. Y. Miura, S. Kimura, Y. Imanishi, J. Umemura, Self-Assembly of a-helix peptide/crown ether conjugate upon complexation with ammonium-terminated alkanethiolate, 14, 2761, 1998.04.
Membership in Academic Society
  • Science Council of Japan
  • The Japan Society of Vacuum and Surface Science
  • The Japanese Society of Carbohydrate Research
  • The Society of Chemical Engineering, Japan
  • the Materials Research Society of Japan
  • Polymer Society Japan
  • The Chemical Society of Japan
  • American Chemical Society
  • The manuscript title of "Interaction Analyses of Amyloid beta Peptide (1-40) with Glycosaminoglycan Model Polymers" was selected as BCSJ award by Japan Chemical Society. In this manuscript, the author described the inhibition of Alzheimer disease using biomaterials. Especially, the authors synthesized glycominoglycan mimic polymer which inhibit the aggregation of Alzheimer amyloid beta aggregation.
Educational Activities
Elementary Organic Chemistry (1st year)
Physical Chemistry (2nd year, Chemical Engineering)
Physical Chemistry III(3rd year, Chemical Engineering(
Bio-resource Materials Engineering(Graduate School)

I am also in charge of the research education of bachelor, master and doctor course students.
Professional and Outreach Activities
Outreach in Elementary School in Itoshima-city (2012), Lecture in Miyazaki-Kita high school (2013), JGFos (2004)
Japan Academy、Committee of Scholar ship、Lecture in Takamatsu -Daiichi High Shcool.