Kyushu University [Kosuke Teshima (Associate Professor) Faculty of Sciences, Department of Biology]

Kosuke Teshima

Last modified date：2020.01.28

Associate Professor / Dynamic biology
Department of Biology
Faculty of Sciences

1 Research Interests

2 Academic Activities

2.1 Papers

2.2 Presentations

2.3 Works,Software and Database

3 Membership in Academic Society

Graduate School

Department of Biology
Graduate School of Sciences

Undergraduate School

Department of Biology
School of Sciences

E-Mail

Academic Degree

Ph.D.

Country of degree conferring institution (Overseas)

Field of Specialization

Population Genetics, Population Genomics

Total Priod of education and research career in the foreign country

04years00months

Research

Research Interests

population genetics for continuously distributing species
keyword : population genetics, simulation, continuous distribution
2019.04～2021.06.
My research interest is to make inferences on evolutionary history of organisms based on genome sequence data.
keyword : population genetics, molecular evolution, genomics, evolution
2011.08～2012.06.

Academic Activities

Papers

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Teshima KM, Innan H, The coalescent with selection on copy number variants, Genetics, 190, 3, 1077-86, 2012.05, We develop a coalescent-based simulation tool to generate patterns of single nucleotide polymorphisms (SNPs) in a wide region encompassing both the original and duplicated genes. Selection on the new duplicated copy and interlocus gene conversion between the two copies are incorporated. This simulation enables us to explore how selection on duplicated copies affects the pattern of SNPs. The fixation of an advantageous duplicated copy causes a strong reduction in polymorphism not only in the duplicated copy but also in its flanking regions, which is a typical signature of a selective sweep by positive selection. After fixation, polymorphism gradually increases by accumulating neutral mutations and eventually reaches the equilibrium value if there is no gene conversion. When gene conversion is active, the number of SNPs in the duplicated copy quickly increases by transferring SNPs from the original copy; therefore, the time when we can recognize the signature of selection is decreased. Because this effect of gene conversion is restricted only to the duplicated region, more power to detect selection is expected if a flanking region to the duplicated copy is used..

Works, Software and Database

[URL].

Presentations

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Membership in Academic Society

Japanese Society for Bioinformatics
Japanese Society of Forest Genetics and Tree Breeding
Society of Evolutionary Studies, Japan
The genetics society of Japan

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