Kyushu University Academic Staff Educational and Research Activities Database
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Mitsuru Tanaka Last modified date:2023.08.10

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Research and Development Center for Five-Sense Devices, Kyushu University .
Lab. Food Analysis, Department of Bioscience and Biotechnology,
Faculty of Agriculture, Kyushu University .
Academic Degree
Ph.D. (Agriculture)
Country of degree conferring institution (Overseas)
Field of Specialization
Food Analysis
Total Priod of education and research career in the foreign country
Outline Activities
Studies on the evaluation of bioavailability of food compounds and the development of analytical techniques for evaluation of food quality.
Research Interests
  • Application of MALDI-MS Imaging for food analysis
    keyword : MALDI-MS Imaging, Food analysis
  • Study on the synergistic enhancement of small peptide-induced vasorelaxation by food components
    keyword : synergistic effect, peptide, vascular function
  • Study on physiological functionality of small peptides on vascular health and its underlying mechanisms
    keyword : Peptide, Vascular relaxation, Hypertension, Atherosclerosis
Academic Activities
1. Mitsuru Tanaka, Toshiro Matsui, Methodologies for investigating the vasorelaxation action of peptides, Biologically Active Peptides, DOI:, Chapter 11, pp255-274, 2021.01.
2. Study on the Physiological Benefits of Food Compounds on Vascular Health and Their Underlying Mechanisms.
1. Mitsuru Tanaka,* Keishiro Arima, Tomotaka Takeshita, Yuri Kunitake, Naoto Ohno, Miho Imamura, and Toshiro Matsui (*Corresponding author), Laser Desorption Ionization−Mass Spectrometry with Graphite
Carbon Black Nanoparticles for Simultaneous Detection of Taste- and Odor-Active Compounds, ACS Applied Nano Materials,, 5, 2187−2194, 2022.01, There is no analytical system to directly and simultaneously detect taste- and odor-active compounds. Graphite carbon black (GCB) nanoparticles, a chemical adsorbent for a variety of compounds, including gaseous molecules, which consists of nanoparticles made from multilayered sheets of sp2-conjugated atomic carbon, have the characteristics required for a surface-assisted laser desorption ionization–mass spectrometry (SALDI-MS) material. Thus, in this study, GCB-LDI-MS was developed for the simultaneous detection of taste- and odor-active compounds. The proposed GCB-LDI-MS successfully detected volatile compounds, including ethyl esters, alcohols, fatty acids, and aldehydes with up to 16 carbons (maximum carbon number of the tested compounds), which could not be detected by conventional matrix-assisted-LDI-MS. Moreover, a series of taste-active compounds (e.g., amino acids and sugars) and various volatile compounds (e.g., ethyl esters, aldehydes, alcohols, fatty acids, and lactones) as a mixture in liquid samples were also detected by the present GCB-LDI-MS. Thus, the proposed simple and rapid detection technique can digitize the analysis of flavor compounds, which provides an analytical concept for flavor scanning to evaluate the palatability of food products..
2. Tae Hun Hahm, Toshiro Matsui*, and Mitsuru Tanaka* (*Corresponding author), Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Tissues via the Formation of Reproducible Matrix Crystals by the Fluorescence-Assisted Spraying Method: A Quantification Approach, Analytical Chemistry, DOI: 10.1021/acs.analchem.1c03369, 94, 1990-1998, 2022.01.
3. Xiaojing Sheng*, Mitsuru Tanaka*, Risa Katagihara, Marika Hashimoto, Satoshi Nagaoka, Toshiro Matsui (*equal contribution), Novel Approach for Simultaneous Analysis of Peptide Metabolites from Orally Administered Glycinin in Rat Bloodstream by Coumarin-Tagged MALDI–MS, Journal of Agricultural and Food Chemistry, DOI: 10.1021/acs.jafc.1c05791, 69, 49, 14840–14848, 2021.12.
4. Tae Hun Hahm*, Mitsuru Tanaka*, Huu-Nghi Nguyen, Ayaka Tsutsumi, Koichi Aizawa, Toshiro Matsui (*equal contribution), Matrix-assisted laser desorption/ionization mass spectrometry-guided visualization analysis of intestinal absorption of acylated anthocyanins in Sprague-Dawley rats, Food Chemistry,, 334, 1, 127586, 1-9, 2020.07, [URL].
5. Mitsuru Tanaka, Chung Hsuan, Masataka Oeki, Weilin Shen, Asuka Goda, Yusuke Tahara, Takeshi Onodera, Keisuke Sanematsu, Tomotsugu Rikitake, Eiji Oki, Yuzo Ninomiya, Rintaro Kurebayashi, Hideto Sonoda, Yoshihiko Maehara, Kiyoshi Toko, Toshiro Matsui, Identification of characteristic compounds of moderate volatility in breast cancer cell lines, PLOS ONE,, 15, 6, e0235442, 2020.06.
6. Mitsuru Tanaka, Shinya Dohgu, Genki Komabayashi, Hayato Kiyohara, Fuyuko Takata, Yasufumi Kataoka, Takashi Nirasawa, Motohiro Maebuchi & Toshiro Matsui, Brain-transportable dipeptides across the blood-brain barrier in mice, Scientific Reports,, 9, 5769, 1-10, 2019.04.
7. Huu-Nghi Nguyen*; Tanaka, Mitsuru*; Li, Baorui; Ueno, Tomoya; Matsuda, Hideki; Matsui, Toshiro (*These authors contributed equally), Novel in situ visualisation of rat intestinal absorption of polyphenols via matrix-assisted laser desorption/ionisation mass spectrometry imaging, SCIENTIFIC REPORTS, 10.1038/s41598-019-39405-w, 9, 3166, 1-9, 2019.02.
8. Seong-Min Hong, Mitsuru Tanaka, Riho Koyanagi, Weilin Shen, Toshiro Matsui, Structural Design of Oligo-peptides for Intestinal Transport Model, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.6b00279., 64, 10, 2072-2079, 2016.03.
9. Jian Zhao, Aki Suyama, Hsuan Chung, Toshihiko Fukuda, Mitsuru Tanaka, Toshiro Matsui, Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells, Life Sciences,, 145, 224-232, 2016.01.
10. Mitsuru Tanaka, Eiji Tanaka, Noe Obinata, Toshiro Matsui, Visualization of Tocopherol Acetate Absorbed Inside Laminated Films by a
Matrix-assisted Laser Desorption/Ionization-imaging Mass Spectrometry, Food Science and Technology Research, doi: 10.3136/fstr.21.821, 21, 6, 821-826, 2015.11.
11. Jian Zhao, Aki Suyama, Mitsuru Tanaka, Toshiro Matsui, Ferulic Acid Enhances the Vasorelaxant Effect of Epigallocatechin Gallate in Tumor Necrosis Factor-Alpha-induced Inflammatory Rat Aorta, The Journal of Nutritional Biochemistry, 10.1016/j.jnutbio.2014.03.013, 25, 7, 807-814, 2014.07.
12. Seong-Min Hong, Mitsuru Tanaka, Saori Yoshii, Toshiro Matsui, Enhanced Visualization of Small Peptides Absorbed in Rat Small Intestine by Phytic-Acid-Aided Matrix-Assisted Laser Desorption/ Ionization-Imaging Mass Spectrometry, Analytical Chemistry, 10.1021/ac402252j, 85, 10033-10039, 2013.09.
13. Mitsuru Tanaka, Jian Zhao, Aki Suyama, and Toshiro Matsui, Epigallocatechin Gallate Promotes the Vasorelaxation Power of the Antiatherosclerotic Dipeptide Trp-His in Contracted Rat Aorta, Journal of Agricultural and Food Chemistry, 10.1021/jf3010228, 60, 9048-9054, 2012, 60, 9048-9054, 2012.09, [URL].
1. Mitsuru Tanaka, Tae Hun Ham, Hun-Nghi Nguyen, Toshiro Matsui, Visualization of absorption and metabolism of polyphenols in rat intestine by nifedipine-aided MALDI-MS imaging, ICoFF/ISNFF2019 (12th International Conference and Exhibition for Nutraceuticals and Functional Foods) Oral presentation, 2019.12.
2. Mitsuru Tanaka, Toshiro Matsui, Screening of synergistic combination of food compounds to exert vasorelaxation effect in rat aorta, ISNFF2017 (The 10th international conference and exhibition on nutraceuticals & functional foods), 2017.10.
3. Seong-Min Hong, Saori Yoshii, Yutaro Morita, Tanaka Mitsuru, Toshiro Matsui, Application of MALDI-MS Imaging to Visualize the Tissue Distribution of Absorbable Small Peptides in Rat Intestine, 2013 International Students Academic Presentation, 2013.03.
Membership in Academic Society
  • The Japanese Society for Food Analysis
  • The Japan Society for Analytical Chemistry
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Japanese Society for Food Science and Technology
  • Japan Society of Nutrition and Food Science
  • Screening of Synergistic Combination of Food Compounds to Exert Vasorelaxation Effect in Rat Aorta
  • Visualization of Tocopherol Acetate Absorbed Inside Laminated Films by a Matrix-assisted Laser Desorption/Ionization-imaging Mass Spectrometry
  • Study on the beneficial effect of food compounds in vascular function