Kyushu University Academic Staff Educational and Research Activities Database
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Fujiwara Toshifumi Last modified date:2024.06.03

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 Reseacher Profiling Tool Kyushu University Pure
Department of Orthopaedic Surgery, Kyushu University .
Academic Degree
Doctor of Philosophy
Country of degree conferring institution (Overseas)
Field of Specialization
Orthopaedic surgery
Total Priod of education and research career in the foreign country
Outline Activities
I reaserch about bone metabolism focusing on osteoclast, and work on clinical rheumatology and bone and soft tissue tumors.
Research Interests
  • The analysis of mechanism of bone destruction in rheumatoid arthritis & bone tumor
    keyword : osteoclast, osteocyte, osteoblast, rheumatoid arthritis
Academic Activities
1. Arisumi S, Fujiwara T, Yasumoto K, Tsutsui T, Saiwai H, Kobayakawa K, Okada S, Zhao H, Nakashima Y., Metallothionein 3 promotes osteoclast differentiation and survival by regulating the intracellular Zn2+ concentration and NRF2 pathway., Cell Death Discov, 2023.12.
2. Soejima Y, Fujiwara T, Fujii M, Tsushima H, Yamaguchi R, Nakashima Y, Arthroscopic Treatment of Septic Arthritis of the Ankle Caused by Group B Streptococcus: A Case Report., Am J Case Rep, 10.12659/AJCR.939719, 2023.06.
3. Kokubu Y, Fujiwara T, Nabeshima Y, Iida K, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Older age at surgery and postoperative leg length discrepancy are risk factors for unfavourable patient-reported outcome measures of knee tumour endoprostheses following resection for musculoskeletal tumour of the lower limb, Bone Joint Open, 2023.10.
4. Tsutsui T, Fujiwara T, Matsumoto Y, Kimura A, Kanahori M, Arisumi S, Oyamada A, Ohishi M, Ikuta K, Tsuchiya K, Tayama N, Tomari S, Miyahara H, Mae T, Hara T, Saito T, Arizono T, Kaji K, Mawatari T, Fujiwara M, Takasaki M, Shin K, Ninomiya K, Nakaie K, Antoku Y, Iwamoto Y, Nakashima Y., Geriatric nutritional risk index as the prognostic factor in older patients with fragility hip fractures., Osteoporos Int, 10.1007/s00198-023-06753-3, 2023.05.
5. Kai K, Fujiwara T, Nagao Y, Oki E, Yoshizumi T, Eto M, Nakashima Y., Evaluation of bone density and skeletal muscle mass after sleeve gastrectomy using computed tomography method., Bone Rep, 10.1016/j.bonr.2023.101661, 2023.02.
6. Kokubu Y, Fujiwara T, Nakagawa K, Setsu N, Endo M, Fukushi JI, Matsumoto Y, Nakashima Y., Postoperative clinical and functional outcomes in patients with tumor and tumor-like lesion of foot and ankle., J Foot Ankle Res, 10.1186/s13047-022-00582-z, 2022.10.
7. Das BK, Wang L, Fujiwara T, Zhou J, Aykin-Burns N, Krager KJ, Lan R, Mackintosh SG, Edmondson R, Jennings ML, Wang X, Feng JQ, Barrientos T, Gogoi J, Kannan A, Gao L, Xing W, Mohan S, Zhao H., Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton., Elife, 10.7554/eLife.73539., 2022.06.
8. Fujiwara T, Kondo M, Yamada H, Haraguchi A, Fujimura K, Sakuraba K, Kamura S, Fukushi JI, Miyahara H, Inoue Y, Tsuru T, Shuto T, Yoshizawa S, Suematsu E, Miyamura T, Ayano M, Mitoma H, Arinobu Y, Niiro H, Ohishi M, Hirata A, Tokunaga S, Takada A, Hara D, Tsushima H, Akasaki Y, Ikemura S, Sueishi T, Toya M, Sakuragi T, Tsutsui T, Kai K, Arisumi S, Nakashima Y., Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry., Arthritis Research and Therapy, 10.1186/s13075-022-02746-5, 2022.02.
9. Momii K, Fujiwara T, Mae T, Tokunaga M, Iwasaki T, Shiomoto K, Kubota K, Onizuka T, Miura T, Hamada T, Nakamura T, Itokawa T, Iguchi T, Yamashita A, Kikuchi N, Nakaie K, Matsumoto Y, Nakashima Y., Risk factors for excessive postoperative sliding of femoral trochanteric fracture in elderly patients: A retrospective multicenter study., Injury, 10.1016/j.injury.2021.07.039., S0020-1383, 21, 00644-00646, 2021.08.
10. Fujiwara T, Tokuda K, Momii K, Shiomoto K, Tsushima H, Akasaki Y, Ikemura S, Fukushi JI, Maki J, Kaku N, Akahoshi T, Taguchi T, Nakashima Y, Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care unit, BMC Rheumatology, 10.1186/s41927-020-00164-1., 2020.12.
11. Toshifumi Fujiwara, Toshihiro Ebihara, Kazuki Kitade, Nokitaka Setsu, Makoto Endo, Keiichiro Iida, Yoshihiro Matsumoto, Tomoya Matsunobu, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima, Risk Factors of Periprosthetic Infection in Patients with Tumor Prostheses Following Resection for Musculoskeletal Tumor of the Lower Limb, Journal of Clinical Medicine, 10.3390/jcm9103133, 9, 10, 2020.10, Tumor prostheses for the lower limb following resection of musculoskeletal tumors is useful limb salvage management; however, as compared with routine total joint replacement, an increased incidence of deep periprosthetic infection of tumor prosthesis has been observed. The risk factors for periprosthetic infection of tumor prosthesis remain unclear. This study examines the risk factors and outcomes of periprosthetic infection. This was a retrospective observational study including 121 patients (67 males and 54 females) who underwent tumor prosthesis of the lower limb after resection of musculoskeletal tumors between 1 January 2000 and 30 November 2018. Among a total of 121 tumor prostheses, 7 were total femurs, 47 were proximal femurs, 47 were distal femurs, and 20 were proximal tibias. The incidence of postoperative infection and its risk factors were analyzed. Forty-five patients (37%) had osteosarcoma, 36 patients (30%) had bone metastasis, and 10 patients (8%) had soft-tissue tumors invading the bone. The mean operating time was 229 min, and the mean follow-up duration was 5.9 years. Deep periprosthetic infection was noted in 14 patients (12%). In the multivariate analysis, the risk factors for postoperative infection were identified as being male (hazard
ratio [HR], 11.2316; p = 0.0100), soft-tissue tumor (HR, 52.2443; p = 0.0003), long operation (HR, 1.0056; p = 0.0184), and radiotherapy (HR, 6.5683; p = 0.0476). The incidence of periprosthetic infection in our institution was similar to that of previous reports. Patients undergoing tumor prosthesis of the lower limb who were male, had a soft-tissue tumor, were predicted to have a long operation, and who underwent radiation, had an increased possibility of postoperative infection..
12. Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y, Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma, American Journal of Pathology, 2011.09.
1. Toshifumi Fujiwara, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Yasuharu Nakashima, Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units, 第65回日本リウマチ学会総会・学術集会, 2021.04.
2. Toshifumi Fujiwara, Shiqiao Ye, Yasuharu Nakashima, and Haibo Zhao, PLEKHM1-DEF8-RAB7 complex in osteoclast regulates lysosome positioning and bone homeostasis., 1st International Orthopaedic Postgraduate Basic Sciences Research Symposium, 2019.04.
3. Toshifumi Fujiwara, Yukio Akasaki, Satoshi Ikemura, Jun-ichi Fukushi, Yasuharu Nakashima, Mortality and complication of patients with rheumatoid arthritis admitted to intensive care unit in Kyushu University Hospital, 第63回日本リウマチ学会総会・学術集会, 2019.04.
Membership in Academic Society
  • Japan Osteoporosis Society
  • The Japanese Society for Bone and Mineral Research
  • American Society of Bone Mineral Reasech
  • The Japan College of Rheumatology
  • The Japanese Orthopaedic Association