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Masataka Ishimura Last modified date：2021.07.16

Assistant Professor / Department of Pediatrics
Comprehensive Maternity and Perinatal Care Center
Kyushu University Hospital


Graduate School
Department of Reproductive and Developmental Medicine
Graduate School of Medical Sciences


Homepage
https://kyushu-u.pure.elsevier.com/en/persons/masataka-ishimura
　Reseacher Profiling Tool　Kyushu University Pure
Phone
092-642-5421
Fax
092-642-5435
Academic Degree
MD, PhD
Country of degree conferring institution (Overseas)
No
Field of Specialization
Pediatric Hematology, Immunology
ORCID(Open Researcher and Contributor ID)
0000-0002-0735-6566
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Primary immunodeficiency diseases
    keyword : PID, epidemiology
    2008.06.
  • Pathogeneisis of autoinflammatory disorder
    keyword : autoinflammatory disorder, pediodic fever
    2017.04.
  • regenerative medicine for congenital coagulation defect
    keyword : regenerative medicine
    2012.04.
  • Research of Early diagnostic method for HNL and JIA
    keyword : early diagnosis method
    2008.04.
  • Gene therapy
    keyword : gene therapy
    2008.04.
Academic Activities
Papers
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1. Takashi Imai, Akira Shiraishi, Kei Nishiyama, Masataka Ishimura, Shouichi Ohga, Lipopolysaccharide-induced monocyte death in a novel ZnF7 domain mutation of TNFAIP3, Journal of Allergy and Clinical Immunology: In Practice, 10.1016/j.jaip.2020.01.026, 2020.01.
2. Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Akira Shiraishi, Shunsuke Kanno, Noriyuki Kaku, Hirosuke Inoue, Yoshitomo Motomura, Masayuki Ochiai, Yasunari Sakai, Manabu Nakayama, Osamu Ohara, Shouichi Ohga, Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis, International journal of hematology, 10.1007/s12185-019-02738-3, 111, 1, 131-136, 2020.01, Hemophagocytic lymphohistiocytosis (HLH) occurs in neonates with disseminated infection of herpes simplex virus (HSV). Little has been reported on the control of rapid HLH progression. We studied the cytokine profile and genetic basis of two index cases with divergent outcomes after early treatment of type 2 HSV infection. One survivor had fever and elevated serum levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), interferon (IFN)-β, and IFN-γ at diagnosis. The other neonate had no fever or TNF-α production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. Among 16 reported cases of neonatal HSV-HLH including index cases, eight deceased neonates experienced significantly less fever at presentation (p = 0.028), lower platelet counts (p = 0.019), and lower ratios of soluble IL-2 receptor (sIL-2R) to ferritin levels (p = 0.044) than eight survivors. The 100-day overall survival rates were significantly higher in patients with fever (p = 0.004), > 100 × 109/L of platelet counts (p = 0.035) or > 20 of sIL-2R/ferritin ratio at diagnosis (p = 0.004). The first febrile and cytokine responses to HSV infection predict the early outcome of neonatal HSV-HLH..
3. Yamamoto H*, Ishimura M*, Ochiai M, Takada H, Kusuhara K, Nakatsu Y, Tsuzuki T, Mitani K, Hara T. *equally contributed, BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector, Gene Therapy, 10.1038/gt.2015.91, 23, 2, 205-213, 2016.02.
4. Ishimura M, Yamamoto H, Mizuno Y, Takada H, Goto M, Doi T, Hoshina T, Ohga S, Ohshima K, Hara T., A non-invasive diagnosis of histiocytic necrotizing lymphadenitis by means of gene expression profile analysis of peripheral blood mononuclear cells., J Clin Immunol., 10.1007/s10875-013-9897-y., 33, 5, 1018-1026, 2013.07.
5. Ishimura M, Takada H, Doi T, Imai K, Sasahara Y, Kanegane H, Nishikomori R, Morio T, Heike T, Kobayashi M, Ariga T, Tsuchiya S, Nonoyama S, Miyawaki T, Hara T , Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan, Journal of Clinical Immunology, 31, 968-976, 2011.12.
6. Ishimura M, Saito M, Ohga S, Hoshina T, Baba H, Urata M, Kira R, Takada H, Kusuhara K, Kang D, Hara T., Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapy.
, Eur J Pediatr., 168, 6, 673-677, 2009.06.
Presentations
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1. 石村　匡崇, An Early and Non-invasive Diagnostic Method for Histiocytic Necrotizing Lymphadenitis

, The 25th Fukuoka International Symposium on Pediatric/Maternal-child health Research, 2014.08.
Membership in Academic Society
  • Japanese Society for Immunodeficiency and Autoinflammatory diseases
  • Japan Pediatric Society
  • Japanese society of hematology
  • The Japanese society of Pediatric hematology/oncology
  • Japanese society for immunology
  • The Japan Society for Clinical Immunology
  • Pediatric Rheumatology association of Japan
  • The Japanese Society on Thrombosis and Hemostasis
Educational
Other Educational Activities
  • 2018.11.


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