Kyushu University Academic Staff Educational and Research Activities Database
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Uehara Norihisa Last modified date:2023.09.25

Assistant Professor / Faculty of Dental Science
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Molecular biology, Cancer cell biology
Total Priod of education and research career in the foreign country
Research Interests
  • Alterations in mechanosensitivity during osteocyte senescence:
    keyword : cellular senescence, osteocyte, mechanosensitivity, intercellular communication
  • Roles of cancer cell-derived extracellular vesicles in the regulation of differentiation and function of bone resident cells.
    keyword : extracellular vesicles, microRNA, bone metastasis, osteoclasts, osteoblasts
  • Identification of tumor suppressive miRNAs induced by histone deacetylase inhibitor vorinostat in human breast cancer cells
    keyword : HDAC inhibitor, Cancer, microRNA
Academic Activities
1. Norihisa Uehara, Yukari Kyumoto-Nakamura, Yoshikazu Mikami, Manabu Hayatsu, Soichiro Sonoda, Takayoshi Yamaza, Akiko Kukita, Toshio Kukita, miR-92a-3p encapsulated in bone metastatic mammary tumor cell-derived extracellular vesicles modulates mature osteoclast longevity, Cancer Science, 10.1111/cas.15557, 113, 12, 4219-4229, 2022.12.
2. Norihisa Uehara, Akiko Kukita, Yukari Kyumoto, Takayoshi Yamaza, Hisataka Yasuda, Toshio Kukita, Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments, Laboratory Investigation, 10.1038/labinvest.2017.55, 97, 10, 1235-1244, 2017.10.
3. Norihisa Uehara, Katsuhiko Yoshizawa, Airo Tsubura, Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells, Oncology Reports, 10.3892/or.2012.1758, 28, 1, 105-110, 2012.07.
4. Hisanori Miki, Norihisa Uehara, Ayako Kimura, Tomo Sasaki, Takashi Yuri, Katsuhiko Yoshizawa, Airo Tsubura, Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells, International Journal of Oncology, 10.3892/ijo.2012.1325, 40, 4, 1020-1028, 2012.04.
5. Norihisa Uehara, Sayaka Kanematsu, Hisanori Miki, Katsuhiko Yoshizawa, Airo Tsubura, Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells, Cancer Letters, 10.1016/j.canlet.2011.07.032, 315, 2, 112-121, 2012.02.
6. Sayaka Kanematsu, Norihisa Uehara, Hisanori Miki, Katsuhiko Yoshizawa, Ayako Kawanaka, Takashi Yuri, Airo Tsubura, Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells, Anticancer Research, 30, 9, 3381-3390, 2010.09.
7. Norihisa Uehara, Yoichiro Matsuoka, Airo Tsubura, Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells, Molecular Cancer Research, 10.1158/1541-7786.MCR-07-0254, 6, 2, 186-193, 2008.02.
8. Norihisa Uehara, Akira Unami, Yasuhiko Kiyozuka, Nobuaki Shikata, Yuji Oishi, Airo Tsubura, Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats, Oncology Reports, 15, 4, 903-911, 2006.04.
9. Norihisa Uehara, Katsuaki Miki, Reiko Tsukamoto, Yoichiro Matsuoka, Airo Tsubura, Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition, Experimental Eye Research, 10.1016/j.exer.2005.08.006, 82, 3, 488-495, 2006.03.
10. Norihisa Uehara, Yu Chien Chou, Jose J. Galvez, Paola de-Candia, Robert D. Cardiff, Robert Benezra, Gopalan Shyamala, Id-1 is not expressed in the luminal epithelial cells of mammary glands, Breast Cancer Research, 10.1186/bcr560, 5, 2, 2003.04.
11. Yu Chien Chou, Norihisa Uehara, Jason R. Lowry, G. Shyamala, Mammary epithelial cells of PR-A transgenic mice exhibit distinct alterations in gene expression and growth potential associated with transformation, Carcinogenesis, 10.1093/carcin/24.3.403, 24, 3, 403-409, 2003.03.
12. Norihisa Uehara, Yoshinori Katakura, Takumi Miura, Sanetaka Shirahata, Subtractive screening of genes involved in cellular senescence, Cytotechnology, 10.1023/A:1008103230335, 35, 1, 35-42, 2001.01.
13. Uehara, N. Katakura, Y. Nishimoto, S. Teruya, K. Shirahata, S., Identification of specific genes involved in cellular senescence by using human lung adenocarcinoma derived cells, Animal Cell Technology: Basic & Applied Aspects, Vol 10, 375-379, 1999.01.
14. Uehara, N. Katakura, Y. Miura, T. Shirahata, S., Molecular cloning and characterization of specific genes involved in cellular senescence, Animal Cell Technology: Challenges for the 21st Century, 1999.01.
1. Norihisa Uehara, Yukari Kyumoto, Akiko Kukita, Toshio Kukita, Breast cancer cell-derived extracellular vesicle-mediating transfer of miRNAs regulates osteoclast function, Cutting Edge of Bone and Mineral Research, 2019.12.
2. 上原 範久, 久本 由香里, 久木田 明子, 久木田 敏夫, Extracellular vesicles from bone metastatic mammary tumor cells facilitate osteoclast formation and bone resorption in vitro., 日本骨代謝学会, 2017.07.
3. 上原 範久, 久本 由香里, 久木田 明子, 久木田 敏夫, Metastatic mammary tumor-derived exosomes promote osteoclast differentiation, 日本骨代謝学会, 2016.07.
4. N. Uehara, Y. Katakura, K. Teruya, S. Shirahata, Molecular cloning and characterization of specific genes possibly involved in cellular senescence, The Joint Meeting of the Japanese Association for Animal Cell Technology and the Europian Society for Animal Cell Technology, 1998.11.
Membership in Academic Society
  • Japanese Society of Anti-Aging Medicine
  • Japanese Cancer Association
  • Japanese Society for Bone and Mineral Research
  • Japanese Association of Anatomists
  • Japanese Association for Oral Biology