


Akihiro Kishimura | Last modified date:2023.09.12 |

Graduate School
Undergraduate School
Other Organization
Other
Administration Post
Executive Adviser to the President
E-Mail *Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari.
Homepage
https://kyushu-u.pure.elsevier.com/en/persons/akihiro-kishimura
Reseacher Profiling Tool Kyushu University Pure
https://www.researchgate.net/profile/Akihiro-Kishimura
ResearchGate .
https://researchmap.jp/read0103082?lang=en
Reserachmap (English) .
http://www.chem.kyushu-u.ac.jp/~cms/english/
The web page of the center for molecular systems. .
https://sites.google.com/view/katayamalab
Katayama Lab's HP. .
Phone
092-802-2851
Fax
092-802-2851
Academic Degree
Ph. D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Polymer Chemistry, Supramolecular Chemistry, Biomaterials, Drug Dleivery System
ORCID(Open Researcher and Contributor ID)
0000-0002-0503-1418
Total Priod of education and research career in the foreign country
00years02months
Research
Research Interests
Membership in Academic Society
- Rational construction of hierarchical structures based on phase separation from transient condensates of biomacromolecules
keyword : Vesicles, Coacervates, Hierachical Structures, Artificial Organellas, Biomacromolecules
2022.04~2022.06. - Development of polymeric yolk-shell structure as a protein-concentration capsule and its application for efficient cascade reaction
keyword : enzyme, proteins, polyion complexes, yolk-shell structure, condensed environment, liquid-liquid phase separation, cascade reactions
2020.06~2020.03. - Establishment of liquid-liquid phase separation model and understanding of function of crowded environments toward artificial cytosol design
keyword : coacervate, liquid-liquid phase separation, proteins
2019.06~2021.03. - TBA
keyword : bioluminescence, nanomedicine, vesicles
2017.04~2019.07. - Establishment of soft material platform based on nano-structured coacervates
keyword : coacervate, block copolymers, polyion complexes, hybrid materials, proteins
2015.04. - TBA
keyword : Drug Delivery System, Nanomedicine, pharmacokinetics, nano-physiology
2018.04~2022.03. - Develpment of novel enzyme-loaded polymeric nano-capsules desinged for in vivo applications
keyword : enzyme, nanoreactors, protein delivery system, nano-medicine, vesicles
2014.04~2017.03. - Development of novel nanoreactor system utilizing molecularly crowded nano-compartments
keyword : Nano-compartment, Vesicles, Molecular Crowding, Enzymatic Reaction
2013.04~2015.03.
Reports
1. | An emerging material “PICsome”: A hot zone between “PEG” and “PEG” Recently, nanomaterials constructed by molecular self-assembly have gathered much attention to develop nano-devices incorporated with many types of drugs. Particularly, hollow capsules are one of promising materials, and recently, we have developed polyion complex vesicles, PICsomes, as novel polymeric vesicles. The most advantageous feature of PICsomes is its simple preparation process: Typically, they can be prepared by simple mixing of oppositely charged block copolymers consisting of poly(ethylene glycol) (PEG) and charged poly(amino acid)s in an aqueous medium. Moreover, many other unique properties of PICsomes have been reported, such as facile tuning of vesicle sizes ranging from 100–400 nm while keeping monodispersed size distribution, semipermeable vesicle membrane, facile loading of various water-dispersed materials, long blood circulation after crosslinking, excellent tumor accumulation based on the enhanced permeability and retention (EPR) effect, and so on. The present review article describes basic design and synthetic strategy of PICsomes, fundamental properties of PICsomes, and recent applications of PICsomes to drug delivery system.. |
2. | Akihiro Kishimura, Horacio Cabral, Kanjiro MIyata, Nanodevices for studying nano-pathophysiology, Advanced Drug Delivery reviews, DOI: 10.1016/j.addr.2014.06.003, 2014.06, Nano-scaled devices are a promising platform for specific detection of pathological targets, facilitating the anal- ysis of biological tissues in real-time, while improving the diagnostic approaches and the efficacy of therapies. Herein, we review nanodevice approaches, including liposomes, nanoparticles and polymeric nanoassemblies, such as polymeric micelles and vesicles, which can precisely control their structure and functions for specifically interacting with cells and tissues. These systems have been successfully used for the selective delivery of reporter and therapeutic agents to specific tissues with controlled cellular and subcellular targeting of biomolecules and programmed operation inside the body, suggesting a high potential for developing the analysis for nano- pathophysiology.. |
3. | Akihiro Kishimura, Development of polyion complex vesicles (PICsomes) from block copolymers for biomedical applications, Polymer Journal, 2013.04, [URL], Polyion complex (PIC) formation is one of the most powerful techniques for obtaining molecular self-assemblies in aqueous media. The simple preparation process based on multiple electrostatic interactions is quite attractive for material syntheses, as well as biomedical applications. Therefore, it is desirable to control PIC architectures at the nanoscale in order to expand the scope of PIC materials. In this review article, recent progress on PIC vesicles (PICsomes) is summarized. PICsomes were first developed by my research group, and we recently succeeded in controlling the sizes and structural uniformity of the vesicles. Furthermore, the characteristic dynamic nature of PICs was revealed: PICs were found to exhibit reversible association/ dissociation and structural transformation. We demonstrated that crosslinking the PIC layers of PICsomes is a powerful method for tuning properties such as stability and permeability. Finally, the potential utility of PICsomes for drug delivery nanocarriers was examined, and their future biomedical application is discussed.. |
4. | Development and Biomedical Applications of Polymeric Hollow Capsules “PICsomes” Possessing Semipermeable Polyion Complex Membrane. |
Papers
Presentations
- Japanese Association for the Advancement of Science
- Japan Epidemiological Association
- The Biophysical Society of Japan
- Protein Science Society of Japan
- Japanese Society for Biomaterials
- The Japan Society of Drug Delivery System
- Controlled Release Society
- American Chemical Society
- The Materials Research Society of Japan
- The Society for Polymer Science, Japan
- The Chemical Society of Japan
- The Pharmaceutical Society of Japan
Educational
Educational Activities
Classes: Bio-organic chemistry (2013-2015), Biochemistry II (2016-), Molecular Biology (2015-2021), Organic Chemistry I (2022)
Bio-nanotechnology (2014-2016)、Chemistry for Medicine I (2017-), Chemistry for Medicine II (2017-), Life Engineering I/II (2017-)
Other Educational Activities
Bio-nanotechnology (2014-2016)、Chemistry for Medicine I (2017-), Chemistry for Medicine II (2017-), Life Engineering I/II (2017-)
- 2022.06, I designed, planned, and implemented the following course as an elective course for the Kyushu University SPRING program (Future-Creation course).
________
[6] Internationality Courses
(IV) Global Young Academy
Theme: Young Generation’s Thought on Relationship between the Future Society and Academia
In June 2022, the 12th International Conference of Young Scientists and GYA Annual General Meeting (GYA AGM2022) will be held at Kyushu University. Utilizing this opportunity, special programs are provided to the course students to develop their international skills and gain a bird’s-eye view of the field across multiple disciplines.
Course requirements: Students must complete the following programs (a) and (b).
Program (a): Attend the following three online sessions of GYA AGM2022 and prepare a report on each. (Submission deadline: June 30th, 2022)
(i) June 15th (Wed, 17:00-18:30) Panel Discussion “Harmonizing Reason with Sensibility from the viewpoint of citizen science: Aiming to build a social system that promotes citizen science”
(ii) June 15th (Wed, 19:00-20:30) Plenary Session 1 “Harmonizing Reason with Sensibility to Enable Sustainable and Inclusive Society: Universities in the Future Society – To be a public platform for realizing a sustainable and inclusive society (tentative)”
(iii) June 16th (Thu, 19:00-20:30) Plenary Session 2 “How much creativity is valued in your area of science?”– How might we contribute better to the society through harmonizing reason with sensibility?”
* Whenever possible, participate on-site at the Opening Ceremony (June 14, 17:00-, at Shiiki Hall), and participate online at the Closing Ceremony (June 17, 17:00-).
Language: English
Program (b): Participate in side events held parallel to the international conference. Participate in one of Course 1 or Course 2. (Participation in both courses is possible. If you want to do so, please contact the person in charge of [6]-(IV)[AK1] ).
(Course 1) English Debate Workshop for High School Students, University Students and Next Generation Researchers
Language: English
Number of students accepted: 8 (If more than 8 students apply, selection will be made by lottery, or by considering a research background of the student and a topic the student prioritizes.)
Course requirements: Participate in and complete a pre-conference lecture (online, the date to be announced) and a debating session (June 14 (Tue), 10:20-16:00 at Shiiki Hall). (Submission deadline of mini-report or assignments will be announced later.)
Note that those who have no experience in debating are welcome to participate. (The Pre-Lecture is a course for inexperienced debaters. Experienced debaters are of course welcome.)
(Course 2)
1. “The Society of 30 Years from Now: A Science Fiction Prototyping Workshop for the Younger Generation” June 15th (Wed, 12:30-16:00m, online).
2. “A Dialogue Between Young Researchers and the Next Generation of Researchers” June 16th (Thu, 13:00-16:00 at Shiiki Hall)
Language: Japanese
Number of students accepted: ~10 students. If there are too many applicants, a lottery may be held.
Course requirements: Participate in and complete both events. (Submission deadline of mini-reports and questionnaire: June 30th, 2022)
*Detailed description of each course is given in the following pages.
Detailed program description (Syllabus)
[Program (a)]
Participate in the following three sessions and submit a one-page, A4-size report on what you have thought about regarding the session topics, as you reflect on your research, life to date, etc. (Submission deadline: June 30th, 2022)
(i) Panel Discussion “Harmonizing Reason with Sensibility from the viewpoint of citizen science: Aiming to build a social system that promotes citizen science”
Day & Time: June 15th (Wed, 17:00-18:30)
Event Format: Online meeting (zoom)
Session description: Citizen science is a scientific activity conducted by the general public and is expanding worldwide. In Japan, however, its social system is not ready to promote citizen sciences; in other words, it is immature in terms of co-creation of research projects among professional researchers, the general public and policymakers, conducting research together, and implementing research outcomes to the society. Therefore, the Young Academy of Japan (YAJ) compiled a list of issues that need to be resolved in implementing citizen sciences in Japanese society compared to other countries and released the recommendation in 2020. In this session, we will introduce the recommendation issued by YAJ in 2020 and the trends in Japan afterward. Also, the global trend of citizen science will be overviewed, together with some important examples. Finally, we will discuss and clarify the significance and challenges of Citizen Science as a key tool to support society in various situations, especially in achieving the SDGs, and how to construct a social system to promote it.
(ii) Plenary Session 1 “Harmonizing Reason with Sensibility to Enable Sustainable and Inclusive Society: Universities in the Future Society – To be a public platform for realizing a sustainable and inclusive society (tentative)”
Day & Time: June 15th (Wed, 19:00-20:30)
Event Format: Online meeting (zoom)
Session description: Universities are the only public places that can strongly connect the daily developing academia to the society. In this plenary session, we will consider the rebalancing of "reason" and "sensibility," and consider the university as a place that connects with the public. In particular, we will have speeches from Dr. Juichi Yamagiwa (the Director-General of the Research Institute for Humanity and Nature), who served as the president of the Science Council of Japan on the theme of strengthening the connection between academia and society through dialogue, and Mr. Oriza Hirata (the president of Professional College of Arts and Tourism), who links education, art and culture to the community through dialogue. In addition, Prof. Takeshi Sakai (Kyushu University) will present a case study of Kyushu University's Ito Campus, which was designed and developed with consideration for the sustainability of the local environment and inclusion of the local community. Finally, in the panel discussion, we will discuss the role of academia and universities in the era of SDGs and post-SDGs.
(iii) Plenary Session 2 “How much creativity is valued in your area of science?”– How might we contribute better to the society through harmonizing reason with sensibility?”
Day & Time: June 16th (Thu, 19:00-20:30)
Event Format: Online meeting (zoom)
Session description: How does society perceive scientists? How does it vary from country to country and field to field? How can scientists contribute more to society? To consider these questions, we are conducting a survey among GYA members and alumni. The session will provide an opportunity for discussion based on the survey result, presentations given by the speakers from different fields, and comments and questions from the audience. We would like to inform a wide range of participants about the discussions that GYA's Focus Area has been having and to have time to think together.
[Program (b)]
Complete either Course 1 or Course 2. (You may take both courses.)
(Course 1)
“English Debate Workshop for High School Students, University Students and Next Generation Researchers”
The workshop will include a pre-conference online lecture and a debating session. Debates deal with topics such as "environment," "virtual reality," "medicine," and "international relations," inviting experts in each field to discuss topics that cannot be settled only with advanced knowledge. In addition, the experts will provide new perspectives through their presentations, and interactive discussions will be held to help students develop their future interdisciplinary research.
1. Pre-conference Online Lecture: Debate Practices with SDGs
Date & Time: TBA (2 periods in a single day)
Event Format: Online lecture
Lecturer: Prof. Toru Oga (Faculty of Law, Kyushu University), et al.
Objective: The objective of this course is to learn about SDG topics (aligned with the 17 goals) through debates. Debates will be conducted by participants randomly assigned to the affirmative or negative side. This is compatible with the SDGs, which are oriented toward a multi-stakeholder approach, because it is necessary to organize the debate from the perspective of others (actors, stakeholders, and those involved in the debate topic) rather than from one's own position.
Keywords: Debate, SDGs, Critical Thinking
Teaching Materials: Textbook, reference books, printed materials/slide materials (available from Moodle)
Textbook: Chihiro Nakagawa, “Improvised English Debate (PDA) in class”, Parliamentary Debate Personnel Development Association (2017).
https://pdpda.org/debate/educational-materials/
Reference Books:
Lewis Iwu, Words That Win: How to Win the Debates That Matter (John Catt Edu Ltd, 2019)
加藤彰『即興型ディベートの教科書』(あさ出版, 2020)
Course Plan:
Course Theme
Course Contents
Pre/Post Study Contents
1
Debate Practice 1
Explanation of Debate Rule, Debate Practice (Environment, AI issues)
Reviewing Debate topic
2
Debate Practice 2
Debate Practice (Medical and Development issues)
Reviewing Debate topic
Evaluation: Mini-Report, Class Participation
(Submission deadline of mini-report or assignment will be announced later.)
2. Debating session
Date & Time: June 14 (Tue, 10:20-16:00)
Event Format: Onsite meeting
Venue: Lecture rooms, Shiiki Hall (Ito Campus)
Program:
(Morning session)
English debates on four topics ((a) Environment, (b) Virtual Reality, (c) Medicine, and (d) International Relations/Development). Students will be the debaters; each team will consist of three debaters (each team will consist of one high school student, one university student, and one SPRING course student). The schedule will be as follows:
Preparation time (15 minutes)
Debating (20 minutes)
Judges' commentary (15 minutes)
Moderator’s presentation (about 30 minutes)
Q&A and floor discussion (approx. 30 minutes)
Guest Moderators:
Theme (a). Environment
Prof. Akira Mori (Research Center for Advanced Science and Technology, the University of Tokyo)
Theme (b). Virtual Reality
Prof. Kouta Minamizawa (Graduate School of Media Design, Keio University)
Theme (c). Medicine
Prof. Mitsunobu Kano (Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University)
Theme (d). International Relations/Development
Prof. Ryoko Nakano (Institute of Human and Social Sciences, Faculty of Law, Kanazawa University)
(Afternoon session)
Two teams will be formed from the debaters who performed well in the morning session to debate on the theme of "SDGs". The program will proceed in the same way as the morning session.
Guest Moderator: Prof. Jinhee Kim (Korean Educational Development Institute)
Evaluation: Class Participation, Mini-Report & Questionnaire (Submission deadline: June 30th, 2022)
(Course 2)
1. “The Society of 30 Years from Now: A Science Fiction Prototyping Workshop for the Younger Generation”
Date & Time: June 15th (Wed, 12:30-16:00)
Event Format: Online meeting (zoom)
Course Outline: Are your research activities, which were exciting at first, becoming routine and getting bored with your daily activities? You may want to revitalize your thinking, which tends to stop when you fall into a routine, or you may want to reevaluate where you stand, because your research itself is in a stagnant period and you are unsure of the value of your research. At such times, thinking about the future from a science fiction perspective may be a breakthrough. In fact, many overseas researchers and innovators have publicly stated that science fiction has helped them in their research and development. Would you like to participate in this SF prototyping where you can imagine a crazy future with various people and explore new research directions?
Dohjin Miyamoto will coordinate the workshop as a leading expert in SF prototyping. You can sufficiently and effectively experience SF prototyping in an online format. On the day of the workshop, participants will work in groups of about 4-5 people, summarize the discussions and outcomes of each group, and finally submit a report.
Overall Coordinator: Dohjin Miyamoto (Science Culture Writer)
Reference: 『SFプロトタイピング SFからイノベーションを生み出す新戦略』宮本道人、難波 優輝 、大澤 博隆・著、早川書房(2021)。
Evaluation: Class Participation, Mini-Report & Questionnaire (Submission deadline: June 30th, 2022)
2. “A Dialogue Between Young Researchers and the Next Generation of Researchers”
Date & Time: June 16th (Thu, 13:00-16:00)
Event Format: Onsite meeting
Venue: Large Meeting Room, Shiiki Hall (Ito Campus)
Course Outline: Discussions will be held to help the next generation of researchers recognize the importance of intergenerational connections across time and disciplines to create a better future intentionally. Together, we will consider how the next generation of researchers can make choices to shape the future society and environment while looking at the successes and failures piled up by the former generations. We will also discuss what kind of community of researchers is needed to encourage the next generation of researchers to make decisions for the future.
A critical viewpoint to consider the relationship between society and science is the balance between understanding based on "reasons" and understanding based on "sensibility" or "emotions." This point is almost the same as the international conference's main theme, "Harmonising Reason with Sensibility." Usually, humans have a discrepancy between reason and sensibility. There are cases in which what is rationally judged as "good" from a certain standpoint is unacceptable from the emotional viewpoint. Conversely, it is difficult to convey what is rationally judged to be "good" to others to empathize.
In this event, we would like researchers of different generations to share some experiences of science communication issues for shaping a better future, examples of science communication to move people beyond reason through artistic approaches, and so forth. In addition, the researchers of the next generation will share their ideas and opinions through discussion and, finally, present outputs obtained in an interactive dialogue.
Participants will work in groups of about 4-5 people on the day, summarize the discussions and outcomes of each group, and finally submit a report.
Program (tentative):
13:00–14:00 Presentations & messages from researchers話題提供(1時間程度)
Speakers (tentative):
Prof. Hitoshi Kuriyama (Faculty of Design, Kyushu University; about the topic on “Science & Art”)
Prof. Nina Yasuda (Graduate School of Agricultural and Life Sciences, the University on Tokyo; about the topic on “Environment, Science and Society”)
Prof. Motoi Wada (Faculty of Science and Engineering, Doshisha University; about the topic on “Nuclear engineering and Society”)
Prof. Ren Yatsunami (Faculty of Law, Kyushu University; about the topic on “Cultural Heritage and the Metaverse”)[AK2]
and 1 or 2 speakers.
14:00–15:30 Group discussion
15:30–16:00 Summary reports from each group
Evaluation: Class Participation, Mini-Report & Questionnaire (Submission deadline: June 30th, 2022).


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