Kyushu University Academic Staff Educational and Research Activities Database
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Naoto Haruyama Last modified date:2021.05.21

Associate Professor / Division of Oral Health, Growth and Development
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School
Other Organization

 Reseacher Profiling Tool Kyushu University Pure
Section of Orthodontics and Dentofacial Orthopedics, , Faculty of Dental Science, Kyushu University .
Academic Degree
D.D.S., Ph. D
Field of Specialization
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Research Interests
  • Roles of store-operated Ca2+ entry in dental and craniofacial tissues.
    keyword : store-operated Ca2+ entry (SOCE), tooth, salivary grands, ectodermal dysplasia
  • Mechanisms of orthodontic tooth movement and invoved factors
    keyword : orthodontics, tooth movement
  • Amelogenins: Multifaceted enamel matrix proteins in hard tissue biology
    keyword : Amelogenin, Enamel matrix protein
Academic Activities
1. Haruyama N, Cho A, and Kulkarni AB., Current Protocols in Cell Biology, John Wiley & Sons, Inc. , Overview: engineering transgenic constructs and mice. Chapter 19: Unit 19.10., 2009.03.
2. Haruyama N, Hatakeyama J, Hatakeyama Y, Gibson CW, Kulkarni AB., M. Goldberg Ed., Amelogenins: multifaceted proteins for dental and bone formation and repair., Bentham Science Publishers Ltd., Lessons from the amelogenin knockout mice. Chapter3, pp. 25-31, 2010.12.
1. Tsuji K, Haruyama N, Nomura S, Murata N, Yoshizaki K, Mitsuyasu T, Nakano H, Nakamura S, Mori Y, Takahashi I., Characteristics of craniofacial morphology and factors affecting them in patients with isolated cleft palate, PeerJ, 10.7717/peerj.11297, 9, e11297, 2021.04, [URL].
2. Minamidate Takao, Haruyama Naoto, Takahashi Ichiro, The development, validation, and psychometric properties of the Japanese version of the Child Oral Health Impact Profile-Short Form 19 (COHIP-SF 19) for school-age children, HEALTH AND QUALITY OF LIFE OUTCOMES, 10.1186/s12955-020-01469-y, 18, 1, 2020.07, Background: This study was performed to develop and validate a Japanese version of Child Oral Health Impact Profile-Short Form (COHIP-SF) 19 and to assess its psychometric properties in Japanese school-age children.
Methods: The original English COHIP-SF 19 was translated into Japanese (COHIP-SF 19 JP) using a standard forward and backward translation procedure. The psychometric properties of the COHIP-SF 19 JP were assessed in 379 public school students between 7 and 18 years of age in Fukuoka, Japan. Internal consistency (Cronbach’s alpha) and test-retest reliability (intraclass correlation coefficient, ICC) were the metrics used for evaluation of this questionnaire. The discriminant validly was examined using the Wilcoxon rank sum test to identify significant differences in COHIP-SF 19 JP scores according to the results of dental examinations. The convergent validity was examined using the Spearman correlations to determine the relationships between COHIP-SF 19 JP scores and the self-perceived oral health ratings. Confirmatory factor analyses (CFA) were performed to verify the factor structure of the questionnaire.
Results: The COHIP-SF 19 JP revealed good internal consistency (Cronbach’s alpha, 0.77) and test-retest reliability (ICC, 0.81). Discriminant validity indicated that children with dental caries or malocclusion had significantly lower COHIP-SF 19 JP scores (P < 0.05); convergent validity indicated that the self-perceived oral health rating was significantly correlated with the COHIP-SF 19 JP total score and subscores (rs = 0.352–0.567, P < 0.0001), indicating that the questionnaire had a sufficient construct validity. CFA suggested that the modified four-factor model had better model fit indices than the original three-factor model.
Conclusion: The collected data showed that the COHIP-SF 19 JP possesses sufficient psychometric properties for use in Japanese school-age children..
3. Furukawa Y, Haruyama N, Nikaido M, Nakanishi M, Ryu N, Oh-hora M, Kuremoto K, Yoshizaki K, Takano Y, Takahashi I., Stim1 Regulates Enamel Mineralization and Ameloblast Modulation, JOURNAL OF DENTAL RESEARCH, 10.1177/0022034517719872, 96, 12, 1422-1429, 2017.11.
4. Cho A, Haruyama N, Hall B, Danton MJ, Zhang L, Arany P, Mooney DJ, Harichane Y, Goldberg M, Gibson CW, Kulkarni AB, TGF-ß regulates enamel mineralization and maturation through KLK4 expression., PLoS One., 10.1371/journal.pone.0082267, 8, 11, e82267, 2013.11.
5. Aukkarasongsup P, Haruyama N, Matsumoto T, Shiga M, Moriyama K., Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells via TGF-β signaling. , Biochem Biophys Res Commun, 441, 1, 126-132, 2013.11.
6. Mitani K, Haruyama N, Hatakeyama J, Igarashi K., Amelogenin splice isoforms stimulate chondrogenic differentiation of ATDC5 cells., Oral Dis., 19, 2, 169-179, 2013.03.
Membership in Academic Society
  • Internal Association for Dental Research
  • Japanese Orthodontic Society
  • Japanese Cleft Palate Association
  • Japanese Association for Jaw Deformities
  • Japanese Association for Oral Biology
Other Educational Activities
  • 2015.04.