Kyushu University Academic Staff Educational and Research Activities Database
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Yasuaki Hiromasa Last modified date:2021.03.05

Graduate School
Undergraduate School

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Biochemistry, Biophysics, Enzyme Chemistry
Total Priod of education and research career in the foreign country
Research Interests
  • Regulation of pyruvate dehydrogenase complex
    keyword : Protein complex, Regulation, Protein-protein-interaction, Allosteric effect
  • Proteomics research of plant and insect proteins.
    keyword : Proteomics
Academic Activities
1. TE. Roche, Yasuaki Hiromasa, Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. , Cell Mol Life Sci. (2007) 64, 830-49, 2007.04.
1. Nguyen Cong Thanh; Nagayoshi, Yuko; Fujino, Yasuhiro; Iiyama, Kazuhiro; Furuya, Naruto; Hiromasa, Yasuaki; Iwamoto, Takeo; Doi, Katsumi, Characterization and Genome Structure of Virulent Phage EspM4VN to ControlEnterobactersp. M4 Isolated From Plant Soft Rot, FRONTIERS IN MICROBIOLOGY, 10.3389/fmicb.2020.00885, 11, 2020.06, [URL].
2. Jiang, Jiansen; Baiesc, Flavius L.; Hiromasa, Yasuaki; Yu, Xuekui; Hui, Wong Hoi; Dai, Xinghong; Roche, Thomas E.; Zhou, Z. Hong, Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex, BIOCHEMISTRY, 10.1021/acs.biochem.8b00357, 57, 16, 2325-2334, 2018.04.
3. Wei Wang, Huaien Dai, Yi Zhang, Raman Chandrasekar, Lan Luo, Yasuaki Hiromasa, Changzhong Sheng, Gongxin Peng, Shaoliang Chen, John M. Tomich, John Reese, Owain Edwards, Le Kang, Gerald Reeck, Feng Cui, Armet is an effector protein mediating aphid-plant interactions, FASEB Journal, 10.1096/fj, 29, 5, 2032-2045, 2015.02.
4. Takahashi, D, Dai, H, Yasuaki Hiromasa, Krishnamoorthi R, Kanost, MR, Self-association of an insect β-1,3-glucan recognition protein upon binding laminarin stimulates prophenoloxidase activation as an innate immune response., Journal of Biological Chemistry, 10.1074/jbc.M114.583971, 289, 41, 28399-28410, 2014.08.
5. G. Bousfield, V. Butnev, V. Butnev, Yasuaki Hiromasa, D. Harvey, J. May, Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)), MOLECULAR AND CELLULAR ENDOCRINOLOGY, 10.1016/j.mce.2013.11.008, 382, 2, 989-997, 2014.02.
6. D. Takahashi, Yasuaki Hiromasa, Y. Kim, A. Anbanandam, X. Yao, KO. Chang, O. Prakash, Structural and dynamics characterization of norovirus protease, PROTEIN SCIENCE, 10.1002/pro.2215, 22, 3, 347-357, 2013.03.
7. H. Dai, Yasuaki Hiromasa, D. Takahashi, D. VanderVelde, J. Fabrick, MR. Kanost, R. Krishnamoorthi, An Initial Event in the Insect Innate Immune Response: Structural and Biological Studies of Interactions between beta-1,3-Glucan and the N-Terminal Domain of beta-1,3-Glucan Recognition Protein, BIOCHEMISTRY, 10.1021/bi301440p, 52, 1, 161-170, 2013.01.
8. JM. Christen, Yasuaki Hiromasa, C. An, MR. Kanost, Identification of plasma proteinase complexes with serpin-3 in Manduca sexta, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 10.1016/j.ibmb.2012.09.008, 42, 12, 946-955, 2012.12.
9. C. An, Yasuaki Hiromasa, X. Zhang, S. Lovell, M. Zolkiewski, JM Tomich, MR. Kanost, Biochemical Characterization of Anopheles gambiae SRPN6, a Malaria Parasite Invasion Marker in Mosquitoes, PLOS ONE, 10.1371/journal.pone.0048689, 7, 11, 2012.11.
10. M. Tomasi, Yasuaki Hiromasa, MR. Pope, S. Gudlur, JM. Tomich, SD. Fleming, Human beta 2-glycoprotein I attenuates mouse intestinal ischemia/reperfusion induced injury and inflammation, MOLECULAR IMMUNOLOGY, 10.1016/j.molimm.2012.05.018, 52, 3-4, 207-216, 2012.10.
11. N. Dittmer, Yasuaki Hiromasa, JM. Tomich, N. Lu, RW. Beeman, KJ. Kramer, MR. Kanost, Proteomic and Transcriptomic Analyses of Rigid and Membranous Cuticles and Epidermis from the Elytra and Hindwings of the Red Flour Beetle, Tribolium castaneum, JOURNAL OF PROTEOME RESEARCH, 10.1021/pr2009803, 11, 1, 269-278, 2012.01.
12. VC. Thomas, Yasuaki Hiromasa, N. Harms, L. Thulow, J. Tomich, LE. Hancock, A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis, MOLECULAR MICROBIOLOGY, 10.1111/j.1365-2958.2009.06703.x, 72, 4, 1022-1036, 2009.05.
13. X. Mo, Yasuaki Hiromasa, M. Warner, AN. Al-Rawi, T. Iwamoto, TS. Rahman, X. Sun, JM. Tomich, Design of 11-residue peptides with unusual biophysical properties: Induced secondary structure in the absence of water, BIOPHYSICAL JOURNAL, 10.1529/hiophysj.107.118299, 94, 5, 1807-1817, 2008.03.
14. Yasuaki Hiromasa, X. Yan, TE. Roche, Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r, BIOCHEMISTRY, 10.1021/bi7014772, 47, 8, 2312-2324, 2008.02.
15. Yasuaki Hiromasa, TE. Roche, Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2, BIOCHEMISTRY, 10.1021/bi701475f, 47, 8, 2298-2311, 2008.02.
16. X. Yu, Yasuaki Hiromasa, H. Tsen, JK. Stoops, TE. Roche, ZH, Hong, Structures of the human pyruvate dehydrogenase complex cores: A highly conserved catalytic center with flexible N-terminal domains, STRUCTURE, 10.1016/j.str.2007.10.024, 16, 1, 104-114, 2008.01.
17. Yasuaki Hiromasa, LY. Hu, TE. Roche, Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2, JOURNAL OF BIOLOGICAL CHEMISTRY, 10.1074/jbc.M513514200, 281, 18, 12568-12579, 2006.05.
Other Educational Activities
  • 2014.02.
  • 2014.01.